1) Emorine LJ, et al:Molecular characterization of the human β3-adrenergic receptor. Science 245:1118-1121, 1989.
2) 斉藤昌之:褐色脂肪とメタボリックシンドローム. 実験医学 25:2291-2297, 2007.
3) Walston J, et al:Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the β3-adrenergic-receptor gene. N Engl J Med 333:343-347, 1995.
4) Widen E, et al:Association of a polymorphism in the β3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns. N Engl J Med 333:348-351, 1995.
5) Yo shida T, et al:Mutation of β3-adrenergic-receptor gene and response to treatment of obesity. Lancet 346:1433-1434, 1995.
6) Yoshioka K, et al:Association of Trp64Arg mutation in the β3-adrenergic receptor gene with NIDDM, current and maximal body mass index. Diabetologia 39:1410-1411, 1996.
7) Kadowaki H, et al:A mutation in the β3-adrenergic receptor gene is associated with obesity and hyperinsulinemia in Japanese subjects. Biochem Biophys Res Commun 215:555-560, 1995.
8) Sakane N, et al:β3-Adrenergic-receptor polymorphism:a genetic marker for Visceral fat obesity and the insulin resistance syndrome. Diabetologia 40二200-204, 1997.
9) Kimura K, et al:Mutated human β3-adrenergic receptor (Trp64Arg) lowers the response to β3-adrenergic agonists in transfected 3T3-L1 preadipocytes. Horm Metab Res 32:91-96, 2000.
10) Umekawa T, et al:Trp64Arg mutation of β3-adrenoceptor gene deteriorates lipolysis induced by β3-adrenoceptor agonist in human omental adipocytes. Diabetes 48:117-120, 1999.
11) Sakane N, et al:β3-adrenoreceptor gene polymorphism:a newly identified risk factor for proliferative retinopathy in NIDDM patients. Diabetes 46:1633-1636, 1997.
12) Fujisawa T, et al:Meta-analysis of the association of Trp64Arg polymorphism of β3-adrenergic receptor gene with body mass index. J Clin Endocrinol Metab 83:2441-2444, 1998.
13) Zhan S, et al:Meta-analysis of the association of the Trp64Arg polymorphism in the β3 adrenergic receptor with insulin resistance. Obes Res 13:1709-1719, 2005.
14) Kogure A, et al:Synergic effect of polymorphisms in uncoupling protein l and β3-adrenergic receptor genes on weight loss in obese Japanese. Diabetologia 41:1399, 1998.
15) Sawa M, et al:Recent developments in the design of orally bioavailableβ3-adrenergic receptor agonists. Curr Med Chem 13:25-37, 2006.