亜鉛欠乏症の臨床

出版社： 金芳堂
著者：
発行日： 2009-10-25
分野： 臨床医学：内科  >  内科学一般
ISBN： 9784765313933
電子書籍版： 2009-10-25 （第1版第1刷）
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亜鉛欠乏症は、とくに高齢者に予想外に大いのである。この書が家庭医に広く読まれることを希望する。そして亜鉛は栄養素としてビタミンと同列にみなし、高齢者では欠乏しやすい栄養素として蛋白質並みに考えて栄養指導して頂きたい。

目次

  • 亜鉛欠乏症の臨床

    ―目次―

    第1章　必須微量栄養素としての亜鉛
    第2章　亜鉛の体内分布と1日必要量
    第3章　亜鉛の生理作用
    第4章　亜鉛欠乏症
    第5章　疾患と亜鉛
    第6章　老化と亜鉛

この書籍の参考文献

参考文献のリンクは、リンク先の都合等により正しく表示されない場合がありますので、あらかじめご了承下さい。

本参考文献は電子書籍掲載内容を元にしております。

第1章 必須微量栄養素としての亜鉛

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第2章 亜鉛の体内分布と1日必要量

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Wastney ME et al:Kinetics of zinc metabolism;Variation with diet,genetics and disease.J Nutr 130:1355S,2000
 
King JC,Klein CL:Zinc.In Modern Nutrition in Health and Disease.(Shils ME et al),Lippincott,Philadelphia p223,2000
 
柳澤裕之:亜鉛の生理,治療(別冊) 87:4,2005
 
柳澤裕之ほか:亜鉛の生理,老年消化器病 19:61,2007
 
宮田學:高齢者の亜鉛欠乏症,日本老年医学会雑誌 44:607,2007
 
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宮田學:高齢者の亜鉛欠乏症,老年医学UPDATE 2008-2009,メジカルビュー社,2008,143
 
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Donnes ER,Wormall A:The zinc content of erythrocytes and leucocytes of blood from normal and leukaemic subjects.Biochem J 78:578,1961
 
Chang TL et al:Determination of magnesium and zinc in human brain tissue by atomic absorption spectroscopy.Anal Chem Acta 34:17 1966
 
Foly B et al:Zinc content of human platelets.Proc Soc Exp Biol Med 128:256,1968
 
Lifschitz MD et al:Circadian variation in copper and zinc in man.J Appl Physiol 31:88,1971
 
常松潔ほか:人体組織ならびに血清の亜鉛定量とその臨床的意義,臨床病理 19:192,1971
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Henkin RI et al:Estimation of zinc concentration of parotid saliva by flameless atomic absorption absorption spectrophotometry in normal subjects and in patients with idiopathic hypogeisia.J Lab Clin Med 86:175,1975
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宮田学:放射化分析法による血球中微量元素の定量,微量金属代謝 12:33,1984
 
宮田学:テフロン多孔膜有機溶媒抽出分離法を用いた生体試料中Mn,Cu,Zn,Feの放射化分析,微量金属代謝 13:151,1985
 
宮田学,奥野資夫ほか:老年者の亜鉛代謝について-加齢による血清亜鉛値の変動並びに亜鉛吸収試験について-,栄養アセスメント2:29,1985
 
Falchuk KH,Hilt KL,Vallee BL;Determination of zinc in biological samples by atomic absorption spectrophotometry.Meth Enzymol 158:422,1988
 
Lavi N,Alfassi ZB:Determination of trace amounts of cadmium,cobalt,chromium,iron,molybudenum,nickel,selenium,vanadium,and zinc in blood and milk by neutron activation analysis.Analyst 115:817,1990
 
細矢信之:生体内亜鉛の測定とその意義,消化器の臨床 2:29,1999
 
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倉澤隆平,久堀周治郎,上岡洋晴ほか:長野県北御牧村村民の血清亜鉛濃度の実態,Biomed Res Trace Elements 16:60,2005
 
宮田學:血中亜鉛測定の意義,医学のあゆみ 225:1273,2008
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Richmond CR et al:Comparative metabolism of radionucleides in animals.I:Uptake and retention of orally administered 65Zn by four mammalian species.Health Phys 8:481,1962
 
Evans GW et al:A proposed mechanism for zinc absorption in the rat.Am J Phys 228:501,1975
 
Lombeck I et al:Absorption of zinc in acrodermatitis enteropathica.Lancet I:855,1975
 
Weismann K et al:65Zn absorption in patients suffering from acrodermatitis enteropathica and in normal adults assessed by whole body counting technique.Br J Dermatol 101:573,1979
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Sullivan JF et al:A zinc tolerance test.J Lab Clin Med 93:485,1979
 
McClain CC et al:Zinc deficiency;A complication of Crohn's disease.Gastroenterology 78:272,1980
 
Aamodt RL et al:Absorption of orally administered 65Zn by normal human subjects.Am J Clin Nutr 34:2648,1981
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Miyata S et al:Metal contents in duodenal aspirates of normal subjects during pancreozymin secretin test.Gastroenterol Jap 17:207,1982
 
Capel ID et al:The assessment of zinc status by the zinc tolerance test in various groups of patients.Clin Biochem 15:257,1982
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vanRij AM et al:Change in zinc metabolism following exercise in human subjects.Biol Trace Elements Res 10:99,1986
 
宮田学,奥野資夫,島村佳成:加齢および諸疾患時における経口亜鉛負荷試験(oral zinc tolerance test)について,微量金属代謝 15:83,1987
 
宮田学,奥野資夫,島村佳成,三宅健夫:老年者における亜鉛の吸収と排泄,日本老年医学会雑誌 24:272,1987
 
宮田学:老年者における検査所見とその意味づけ-膵機能検査-,臨床検査MOOK No29「老年者の検査」,金原出版:154,1988
 
Lee HH,Prasad AS,Brewer GJ,Owyang C:Zinc absorption in human small intestine.Am J Physiol 256:C87,1989
 
荒川泰行,鈴木壱知,鈴木慶子,松尾裕:微量元素のトレランステスト-経口亜負荷試験を中心に-,最新医学 45:733,1990
 
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高木洋治,岡田正,根津理一郎:亜鉛の生体内代謝,消化器の臨床 2:20,1999
 
Lonnerdal B:Dietary factors infuluencing zinc absorption.J Nutr 130:1378S,2000
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Krebs NF:Overview of zinc absorption and excretion in the human gastrointestinal tract.J Nutr 133:1374S,2000
 
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Nishimura Y et al:L-carnosine and close derivatives accelerate zinc uptake from the intestine in rats.Biomed Res Trace Elements 12:159,2001
 
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Jackson MJ et al:Tissue zinc levels as an index of body zinc status.Clin Physiol 2:333,1982
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Baer M,King JC:Tissue zinc levels and zinc excretion during experimental zinc depletion in young men.Am J Clin Nutr 39:556,1984
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Wada I,Turnlund JR,King JC:Zinc utilization in young men fed adequate and low zinc intakes.J Nutr 115:1345,1985
 
Taylor CM,Bacon JR et al:Homeostatic regulation of zinc absorption and endogeneous losses in zinc-deprived men.Am J Clin Nutr 53:755,1991
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Lee DY,Prasad AS et al:Homeostasis of zinc in marginal human zinc deficiency:Role of absorption and endogenous excretion of zinc.J Lab Clin Med 122:549,1993
 
Van Wouwe JP,Uijlenbroek JJM:The role of the pancreas in the regulation of zinc status.Biol Trace Element Res 42:143,1994
 
De Lisle RC et al:Metallothionein is a component of exocrine pancreas secretion:Implications for zinc homeostasis.Am J Physiol 271:C1103,1996
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King JC et al:Zinc homeostasis in humans.J Nutr 130,1360S,2000
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神戸大朋:亜鉛トランスポーターとその分泌系における役割,細胞工学 27:231,2008
 
神戸大朋:分泌経路における亜鉛酵素の活性化機構-亜鉛トランスポーターによる制御-,Biomed Res Trace Elements 20:150,2009
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藤代瞳,姫野誠一郎:微量元素とトランスポーター,臨床検査 53:155 2009
 
川崎英二,江口勝美:亜鉛トランスポーター(ZnT8)の一塩基多型とI型糖尿病の診断,Biomed Res Trace Elements 20:151,2009
 
深田俊幸:亜鉛トランスポーターS1c39a13/Zip13 の結合組織発生における役割とヒト遺伝性疾患の関与,Biomed Res Trace Elements 20:153,2009
 
武田厚司:脳機能発言における金属の役割,Biomed Res Trace Elements 20:154,2009
 
P.31 掲載の参考文献
木村修一:微量元素の必須性,最新医学 45:808,1990
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Fung EB et al:Zinc absorption in women during pregnancy and lactation:Longitudinal study.Am J Clin Nutr 66:80,1997
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糸川嘉則:高齢者の微量元素欠乏症とその臨床の実際,日本医師会雑誌 129:635,2003
 
鈴木和春:機能性栄養素としての微量元素と食物・サプリメント,治療 88:1886,2006
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糸川嘉則:高齢者の微量元素の栄養状態の評価とその臨床,治療 88:1891,2006
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江指隆年,花井美保:日本人の食餌摂取基準(2005年版)にみる微量元素の所要量決定の考え方,治療 88:1843,2006
 
西牟田守:微量元素の食餌摂取基準(2005年版)について,Biomed Res Trace Elements 19:3,2008
 
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McCord CP et al:An occupational disease among zinc workers.Arch Int Med 37:641,1926
 
Laurence G:Zinc poisoning.Brit Med J 1:582,1958
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Murphy JV:Intoxication following ingestion of elemental zinc.JAMA 212:2119,1970
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田中久:微量必須金属としての亜鉛の有用性と安全性,薬局 48:1297,1997
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和田攻,柳澤裕之:微量元素,特に亜鉛の有用性と安全性,医薬ジャーナル 33:126,1997
 
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Murphy EW et al:Provisional tables on the zinc content of doods.J Am Diet Asoc 66:345,1975
 
原敦子:日本人の常食する食品中のマグネシウム,マンガン,亜鉛および銅含量,栄養と食糧 30:381,1977
 
Golden MHN et al:Potential importance in human nutrition with particular reference to zinc and vanadium.Br Med Bull 37:31,1981
 
鈴木泰夫編:食品の微量元素含有量表,第一出版,1993
 
香川芳子監修:四訂増補食品成分表,女子栄養大学出版部,1997
 
香川芳子監修:五訂増補食品成分表,女子栄養大学出版部,2009
 

第3章 亜鉛の生理作用

P.36 掲載の参考文献
Bettger WJ,O'Dell BL:A critical physiological role of zinc in the structure and function of biomembranes.Life Sci 28:1425,1981
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Wastney ME et al:Kinetic analysis of zinc metabolism and its relation in normal humans.Am J Physiol 251:R398,1986
 
Vallee BL,Falchuk KH:The biological basis of zinc physiology.Physiol Rev 73:79,1993
 
O'Dell BL:Role of zinc in plasma membrane function.J Nutr 130:1432S,2000
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Yanagisawa H,Nodera M:Zinc Physiology and Clinical Practice.Biomed Res Trace Elements 18:3,2007
 
P.37 掲載の参考文献
Keilin D,Mann T:Carbonicanhydrase.Purification and nature of the enzyme.Biochem J 34:1163,1940
 
Malmstrom BG,Neilands JB:Metalloproteins.Ann Rev Biochem 33:331,1964
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野崎光洋:金属酵素研究の進歩,代謝 12:229,1975
 
山崎素直:微量金属の生体内作用機能,代謝 20:595,1983
 
Vallee BL,Gardes A:The metallobiochemistry of zinc enzymes.Adv Enzymol 56:283,1984
 
坂井和男,山根靖弘:金属酵素,最新医学 45:796,1990
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江崎信芳,左右田健次:酵素活性化因子としての微量元素,日本臨床 54:17,1996
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McCall KA et al:Function and mechanism of zinc metalloenzymes.J Nutr 130:1437S, 2000
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P.39 掲載の参考文献
Wacker WEC,Vallee BL:Nucleic acid and metals.I Chromium,manganese,nickel,iron and other metals in ribonucleic acid from diverse biological sources.J Biol Chem 234:3257,1959
 
Fujioka M,LiebermanI:A Zn++ requirement for synthesis of deoxy ribonucleic acid by rat liver.J Biol Chem 239:1164,1964
 
Drake JW:Comparative rates of spontaneous mutation.Nature 221:1132,1969
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Kominami S,Wee VT,Rukiez P Effects of metal ions on the formation of radials and standard breaks and hydrogen transfers in γ-irradiated DNA.Radiat Res 62:422,1975
 
Engelke DR et al:Specific interaction of a purified transcription factor with an internal control region of 5S-RNA genes.Cell 19:717,1980
 
坂井和男,山根靖弘:金属と核酸,代謝 20:605,1983
 
Klug A,Rhodes D:"Zinc fingers":A novel protein motif for nucleic acid recognition.Trends Biochem Sci 12:461,1987
 
Berg JM:Zinc finger domains-Hypothesis and current knowledge-.Ann Rev Biophys Chem 19:405,1990
 
江崎信芳,左右田健次:遺伝子と微量元素,最新医学 45:764,1990
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古川達夫:必須微量元素の細胞内情報伝達機構に果たす役割,日本臨床 54:26,1996
 
Giel-Pietraszuk M,Barciszewska MZ:Additivity of interactions of zinc finger motifs in specific recognition of RNA.J Biochem 131:571,2002
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三原久明,江崎信芳:遺伝子と微量元素,治療 88:1859,2006
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P.40 掲載の参考文献
Pories WJ et al:Acceleration of wound healing in man with zinc sulfate given by mouth.Lancet 1:121,1967
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Sandstead H et al:Zinc and wound healing.Effects of zinc deficiency and zinc supplementation.Am J Clin Nutr 23:514,1970
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Larson DL et al:Zinc deficiency in burned children.Plast Reconstr Surg 46:13,1970
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Henzel JH et al:Zinc concentrations within healing wounds.Arch Surg 100:349,1970
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Lindman RD et al:Influence of acute tissue ihjury of zinc metabolism in man.J Lab Clin Med 79:452,1972
 
Hsu THS et al:Zinc deficiency and epitheliar wound repair:An autoradiographic study of 3H-thymidin incorporation.Proc Soc Exp Biol Med 140:157,1972
 
木村信良:外科領域における亜鉛欠乏,微量金属代謝 1:37,1975
 
出射靖生:創傷時の亜鉛代謝に関する研究,関西医科大学雑誌 28:772,1976
 
Hallbook T et al:Zinc metabolism and surgical trauma.Br J Surg 64:271,1977
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P.41 掲載の参考文献
Kirschner H,Ruhl H:Stimulation of human peripheral lymphocytes by Zn2+ in vitro.Exp Cell Res 61:229,1970
 
Klassing K:Effect of inflammatory agents and interleukin-1 on iron and zinc metabolism.Am J Physiol 247:R901,1984
 
大沢基保:免疫と微量元素,最新医学 45:747,1990
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Berg JM:Zinc finger domains.Hypothesis and current knowledge.Annu Rev Biophys Chem 19:405,1990
 
児玉浩子:免疫機能維持に関わる必須微量元素の役割,日本臨床 54:46,1996
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Fraker PJ et al:The dynamic link between the integrity of the immune system and zinc status.J Nutr 130:1399S,2000
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Rinc L,Kichner H:Zinc-Altered immune function and cytokine production.J Nutr 130:1407S,2000
 
荒川泰昭:免疫機能と微量元素,治療 88:1871,2006
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深田俊幸,山崎哲,北條慎太郎,西田圭吾,村上正晃,平野俊夫:免疫機構における亜鉛の役割,日本医事新報 4343:63,2007
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山崎哲,西田圭吾,平野俊夫:免疫における亜鉛シグナルの役割;亜鉛は細胞内シグナル分子,臨床免疫・アレルギー科 49:683,2008
 
荒川泰昭,小川康恭,荒記俊一:微量元素と免疫機能,臨床検査 53:191,2009
 
P.42 掲載の参考文献
浅田浩二:活性酸素の生成消去作用,蛋白質・核酸・酵素 33:2659,1988
 
吉川敏一,内藤裕二,谷川徹ほか:亜鉛-カルノシン化合物Z-103 のスーパーオキシド消去作用,医学のあゆみ 147:927,1988
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Yoshikawa T,Naito Y,Tanigawa T et al:The antioxidant properties of a novel zinc-carnosine chelate compound,N(3-amino-propionyl)L-histidine zinc.Biochem Biopys Acta 1115:15,1991
 
Powell SR:The antioxidant properties of zinc.J Nutr 130:1147S,2000
 
佐藤英介,宮本佳織,井上正康:活性酸素と微量元素,治療 88:1865,2006
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P.43 掲載の参考文献
木村正巳:メタロチオネイン,代謝 12:205,1975
 
鈴木和夫:最近の動向からみたメタロチオネイン,医学のあゆみ 116: 611,1981
 
森田昌俊:メタロチオネインとその生物学的役割,代謝 20:23,1983
 
Hammer DH:Metallothionein.Ann Rev Biochem 55:913,1986
 
小島豊:メタロチオネイン,最新医学 45:8,1990
 
鈴木和夫:メタロチオネインの構造と機能,日本臨床 54:33,1996
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Thornally PJ,Vasak KM:Possible role for metallothionein in protection against radiation induced oxidative stress.Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals.Biochem Biophys Acta 827:36,1985
 
安部晋也他:エンドトキシンショック時における亜鉛,銅の変動,医学のあゆみ 133:118,1985
 
伊藤俊弘,斉藤和雄:ストレスと微量元素,最新医学 45:638,1990
 
斉藤和雄:ストレス研究に関する最近の知見とその展望,Thrapeutic Reesearch 12:2083,1991
 
木村恵美子:ストレスと微量元素, 治療 88:638,2006
 
大高道郎ほか:高齢者消化器疾患における亜鉛の重要性-亜鉛による消化管粘膜保護作用を含めて-,老年消化器病 19:73,2007
 
P.44 掲載の参考文献
Apgar J:Effect of zinc deficiency on maintenance of pregnancy in the rat.J Nutr 100:470,1970
 
Halstead A et al:Zinc deficiency in man.The Shiaz experiment.Am J Med 53:277,1972
 
Meticoff J et al:Maternal nutrition and fetal outcome.Am J Clin Nutr 34:708,1981
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篠原厚子:内分泌・生殖機能と微量元素,治療 88:1970,2006
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Henkin RI,Bredy GF:Regulation of taste acuity by thiol and metal ions.Proc Natl Acad Sci 62:30,1969
 
小山範正:味覚の生理学1,医学のあゆみ 80:27,1972
 
佐藤昌康:味覚の生理学4,医学のあゆみ 80:515,1972
 
Henkin RI et al:A zinc protein isolated from human saliva.Proc Natl Acad Sci 72:488,1975
PubMed
Henkin RI et al:Estimation of zinc concentration of parotid saliva by flameless atomic absorption spectrophotometry in normal subjects and in patients with idiopathic hypogeusia.J Lab Clin Med 86:175,1975
PubMed
冨田寛ほか:亜鉛と味覚障害,微量金属代謝 1:61,1975
 
冨田寛:味覚の臨床,日本耳鼻咽喉科学会雑誌 79:1267,1976
 

第4章 亜鉛欠乏症

P.46 掲載の参考文献
Todd WR et al:Zinc in the nutrition of the rat.Am J Physiol 107:146,1934
 
Prasad AS,James AH,Manucher N:Syndrome of iron deficiency anemia,hepatosplenomegaly,hypogonadism,dwarfism and geophagia.Am J Med 31:532,1961
 
Prasad AS et al:Biochemical studies on dwarfism,hypogonadism, and anemia.Arch Intern Med 111:407,1961
 
Prasad AS et al:Zinc metabolism in patients with the syndrome of iron deficiency anemia,hepatosplenomegaly and hypogeusia. J Lab Clin Med 61:537,1963
 
Prasad AS:Clinical manifestations of zinc deficiency.Ann Rev Nutr 5:341,1985
 
Hambidge M:Human zinc deficiency.J Nutr 130:1334S,2000
 
Wapnir RA:Zinc deficiency.malnutrition and the gastrointestinal tract.J Nutr 130:1388S,2000
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柳澤裕之:亜鉛欠乏症の臨床,日本医師会雑誌 127:261,2002
 
柳澤裕之:亜鉛欠乏症とその臨床の実際,日本医師会雑誌 129:613,2003
 
P.47 掲載の参考文献
Danbolt N,Closs K:Acrodermatitis enteropathica.Acta Dermatovener 23:127,1942
 
Dillaha CJ et al:Acrodermatitis enteropathica.JAMA 152:509,1953
 
Berggren L et al:Treating acrodermatitis enteropathica.Lancet 1:52,1966
 
Barnes PM,Moynahan EJ:Zinc deficiency in acrodermatitis enteropathica.,multiple dietary intolerance treated with synthetic diet.Proc Roy Soc Med 66:329,1973
 
Moinahan EJ:Acrodermatitis enteropathica;A lethal inherited human zinc deficiency disorder.Lancet 2:399,1974
 
Nelder KH,Hambidge KM:Zinc therapy of acrodermatitis enteropathica.New Eng J Med 292:879,1975
 
森嶋隆文ほか:亜鉛内服が奏効した腸性肢端皮膚炎の1例,臨床皮膚科 29:991,1975
 
森嶋隆文,八木滋,遠藤幹夫:亜鉛欠乏症としての腸性肢端皮膚炎-亜鉛内服奏効例を中心として-,微量金属代謝 1 :49,1975
 
森嶋隆文,藤澤重樹:腸性肢端皮膚炎(亜鉛欠乏症候群),最新医学 45:692,1990
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瀧田誠司ほか:腸性肢端皮膚炎とZn 代謝,小児医学 25:349,1992
 
森嶋隆文ほか:遺伝性亜鉛欠乏症,Biomed Res Trace Elements 8:1,1997
 
P.49 掲載の参考文献
Hambidge KM et al:Low levels of zinc in hair,anorexia,poor growth,and hypogeusia in children.Pediatr Res 6:868,1972
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Solomons NW et al:Growth retardation and zinc nutrition.Pediatr Res 10:923,1976
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森嶋隆文ほか:長期無乳糖ミルク栄養中の乳児に発症した腸性肢端皮膚炎様病変,皮膚臨床 21:329,1979
 
Higashi A,Ikeda T,Uehara I,Matsuda I:Effect of low content zinc and copper formula of infant nutrition.Eur J Pediatr 138,237,1982
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Franceschi C,Chiricolo M et al:Oral zinc supplementation in Down syndrome;restoration of thymic endocrine activity and some immune defects.J Ment Defic Res 32:169,1988
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岩田久夫ほか:低亜鉛母乳による獲得型腸性肢端皮膚炎の兄弟例,皮膚 32:169,1988
 
東明正,松田一郎:未熟児と微量元素,小児医学 25:299,1992
 
Nakamura T,Nishiyama S et al:Mild to moderate zinc deficiency in short children;effect of zinc supplementation on linear growth velocity.J Pediatr 123:65,1993
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千葉百子,篠原厚子ほか:粉ミルク中の元素濃度,日本小児科学会誌 102:6,1998
 
Friel JK et al:Zinc supplementation in very-low birthweight infants.J Pediatr Gastroenterol Nutr 17:388,1998
 
Kaji M et al:Studies to determine the usefulness of the zinc clearance test to diagnose marginal zinc deficiency and the effects of oral zinc supplementation for short children.J Am Coll Nutr 17:388,1998
 
嶋岡正利:低亜鉛母乳による獲得性腸性肢端皮膚炎,皮膚病診療 24:865,2002
 
中山文子,小田裕次郎ほか:低亜鉛母乳による腸性肢端皮膚炎,皮膚病診療 25:303,2003
 
児玉浩子:新生児・小児の微量元素欠乏症とその臨床の実際,日本医師会雑誌 129:631,2003
 
Sur D,Gupta DN et al:Impact of zinc supplementation on diarrheal morbidity and growth pattern of low birth weight infants in Kolkata,India:A andomized,double-blind,placebo-controlled,community based study.ediatrics 112:1327,2003
 
児玉浩子ほか:小児と亜鉛,治療(別冊) 87:16,2005
 
児玉浩子:新生児・小児の微量元素の栄養状態の評価とその臨床,治療 88:1896,2006
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岡田正:高カロリー輸液施行時にみられた亜鉛欠乏症,医学のあゆみ 92:436,1975
 
高木洋治,岡田正:高カロリー輸液と亜鉛,微量金属代謝 3:53,1976
 
Okada A et al:Skin lesions during intravenous hyperalimentation:Zinc deficiency.Surg 80:629,1976
 
Kay RG et al:A syndrome of acute zinc deficiency during total parenteral alimentation in man.Ann Surg 183:331,1976
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Wolman SL,Anderson GH et al:Zinc in total parenteral nutrition.Requirements and metabolic effects.Gastroenterology 76:458,1979
PubMed
Ortega SS et al:Zinc deficiency dermatitis in parenteral nutrition.An EM study.Dermatologica 171:163,1985
 
根津理一郎ほか:高カロリー輸液と微量元素,最新医学 45:706,1990
Medical*Online
根津理一郎ほか:経静脈栄養・経腸栄養と微量元素,小児医学 25:283,1992
 
高木洋治ほか:静脈栄養と微量元素,治療 75:1007,1993
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正田良介ほか:経腸栄養と微量元素欠乏症,JJPEN 20:255,1998
 
丹藤雄介,渡辺拓,中村光男ほか:完全静脈栄養と亜鉛,消化器の臨床 2:71,1999
 
山口之利ほか:長期経静脈・経腸栄養と微量元素異常,小児科 43:625,2002
 
高木洋治,岡田正:経静脈・経腸栄養患者の微量元素異常とその臨床の実際,日本医師会雑誌 129:625,2003
 
高木洋治,岡田正:経静脈・経腸栄養法と微量元素異常の臨床,治療:1975,2006
 
湧上聖:長期経腸栄養における微量元素投与量と摂取基準の相違,Biomed Res Trace Elements 19:13,2008
 
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American Institute of Nutrition 1985:Association of zinc nutritional status of the U.S.Population based on data collected in the Second National Health and Nutrition Examination Survey,1976-1980
 
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Briefel RR et al:Zinc intake of the U.S. population;Findings from the Third National Health and Nutrition Examination Survey,1988-1994.J nutr 130:1767S,2000
 
松浦麗子,松浦伸:中高年女性における亜鉛欠乏症症例の検討,日本産婦人科学会誌 55:285(S-267),2003
 
糸川嘉則:高齢者の微量元素欠乏症とその臨床の実際,日本医師会雑誌 129:635,2003
 
倉澤隆平,久堀周二郎,上岡洋晴ほか:長野県北御牧村村民の血清亜鉛の実態, Biomed Res Trace Elements 16:60,2005
 
倉澤隆平:高齢者と亜鉛,治療(別冊) 87:9,2005
 
長野県国民健康保険団体連合会,長野県国保直診医師会:亜鉛欠乏症について-亜鉛欠乏症の臨床および住民の微量元素亜鉛の不足傾向について-,2006
 
丹藤雄介ほか:高齢者栄養アセスメントにおける亜鉛欠乏の位置づけ,老年消化器病 19:99 2007
 
宮田學:高齢者の亜鉛欠乏症,日本老年医学会雑誌 44:677,2007
 
倉澤隆平,久堀周次郎:地域住民にみる亜鉛欠乏の実態と亜鉛の有効性,微量栄養素研究 25:1,2008
 
P.54 掲載の参考文献
Whitehouse RC et al:Zinc in plasma,neutrophils,lymphocytes and erythrocytes as determined by flameless atomic absorption spectrophotometry.Clin Chem 28:475,1982
PubMed
Weismann K,Hoyper H:Serum alkaline phosphatase and sereum zinc levels in the diagnosis and exclusion of zinc deficiency in man.Am J Clin Nutr 41:1214,1985
 
小林秀之,根津理一郎,高木洋治,岡田正:アンギオテンシン変換酵素(ACE)活性を用いた亜鉛栄養状態の臨床的評価の検討-血漿ACE 比測定法の検討および意義について-,Biomed Res Trace Elements 6:117,1995
 
Samman S et al:Is erythrocyte alkaline phosphatase activity a marker of zinc status in humans?Biol Trace Element Res 51:285,1996
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Wood RJ:Assessment of marginal zinc status in humans.J Nutr 130:1350s,2000
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高木洋治ほか:亜鉛欠乏時における生体反応,Biomed Res Trace Elements 13:114,2002
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Yokoi K et al:Association between plasma zinc concentration and zinc kinetic parameters in premenopausalwomen.Am J Physiol Endocrinol Metab 285:E1010,2003
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冨田寛ほか:エビデンスに基づいた血清亜鉛値の診断基準値,Biomed Res Trace Elements 18:54,2007
 
日暮和彦ほか:生化学自動分析装置を用いた亜鉛比色測定法,Biomed Res Trace Elements 18:380,2007
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宮田學:血中亜鉛測定の意義,医学のあゆみ 225:1273,2008
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冨田寛:日本人の血清亜鉛値の基準値についての提言,Biomed Res Trace Elements 18:22,2008
 
柳澤裕之ほか:亜鉛,広範囲血液・尿化学検査,日本臨床増刊号:2009,印刷中
 
P.55 掲載の参考文献
服部孝夫ほか:低亜鉛血症と亜鉛療法, 医学のあゆみ 106:594,1975
 
岡田正,高木洋治:外科における低亜鉛血症,現代外科学体系,78-E,中山書店,東京:143,1978
 
Hallbook T,Hadelin H:Changes in serum zinc and copper induced by operative trauma and effects of pre-and post-operative zinc infusion.Acta Chir Scand 144:423,1978
 
岡田正:微量元素欠乏症の臨床-特に診断と治療-,Biomed Res Trace Elements 7:1,1996
 
宮田學:老人病における亜鉛の有効性について,臨床化学 36(suppl 1):101,2007
 

第5章 疾患と亜鉛

P.57 掲載の参考文献
Vikbladh I:Studies on zinc in blood.Scand J Clin Lab Invest 3(suppl 2):1,1951
 
Vallee BL,Wacker WEC et al:Zinc metabolism in hepatic dysfunction.1.Serum zinc concentration in Laennec's cirrhosis and their validation by sequential analysis.New Eng J Med 255:403,1956
 
Hammond JB,Block HR,Cullison JL:Effect of oral zinc therapy in cirrhosis.Dig Dis 5:923,1960
 
Halsted JA,Hackley B et al:Plasma zinc concentration in liver disease.Comparison with normalcontrols and certain other chronic diseases.Gastroenterology 54:1098,1968
 
船越泰子,奥村恂ほか:肝疾患における亜鉛・銅代謝について,日本消化器病学会誌 6:1222,1969
 
Prasad AS,Oberleas D,Rajasekavan G:Essential micronutrient elements.Biochemistry and changes in liver disorders.Am J Clin Nutr 23:581,1970
 
Sullivan JF,Heaney RP:Zinc metabolism in chronic liver disease.Am J Clin Nutr 23:170,1970
 
奥村恂,船越康子:重金属代謝と肝・胆道疾患,臨床と研究 48:2155,1971
 
Walker BE,Dawson JB et al:Plasma and urinary zinc in patients with malabsorption syndromes or hepatic cirrhosis.Gut 14:943,1973
PubMed
Versieck J,Barbier F,Speeke A et al:Manganese,copper and zinc concentrations in serum and packed blood cells during acute hepatitis,chronic hepatitis and post hepatitis cirrhosis.Clin Chem 20:1141,1974
 
亀田幸男:肝疾患と亜鉛,肝胆膵 10:915,1985
 
富樫整ほか:各種肝疾患における肝細胞内Superoxide dismutase 活性と過酸化脂質の検討,日本消化器病学会誌 82:2327,1985
 
新沢陽英ほか:肝組織中微量金属濃度とSOD活性の比較検討,日本消化器病学会誌 84:2086,1987
 
安本潔,神代龍吉,麻生重仁ほか:急性肝障害における低亜鉛血症の成因についての検討,日本消化器病学会誌 85 :2590,1988
 
永井孝三:慢性肝疾患における亜鉛代謝異常に関する研究-第1報-,日本消化器病学会誌 85:2618,1988
 
荒川泰行ほか:肝疾患と微量元素,最新医学 45:668,1990
Medical*Online
Rocci E,Borella P et al:Zinc and magnesium in liver cirrhosis.Eur J Clin invest 24:149,1994
 
大元謙治:肝疾患と亜鉛,消化器の臨床 2:59,1999
 
Grungreiff K:Zinc in liver disease.Trace Elem Res Exp Med 15:67,2002
 
Arakawa Y et al:Liver cirrhosis and metabolism(sugar,protein,fat and trace elements).Hepatol Res 30s :S46,2004
 
森山光彦,金子弥樹,荒川泰行:肝機能と亜鉛,治療(別冊) 87:46,2005
 
荒川泰行ほか:肝疾患と微量元素,治療 7:1907,2006
Medical*Online
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Ohtaka H et al:Zinc binding protein in the liver of neonatal,normal and partially hepatectomized rats.Biochem J 174:999,1978
 
友田和彦:亜鉛の生体内代謝に及ぼす影響に関する実験的研究-部分的肝切除後の肝再生を中心として-,関西医科大学雑誌 33:230,1981
 
鈴木慶子:ラット肝再生におけるカルノシン亜鉛の補充効果に関する研究,日大医誌 49:157,1990
 
鈴木慶子,鈴木壱知,原典子ほか:肝再生におけるZ-103(カルノシン亜鉛)の効果,Biomed Res Trace Elements 1:35,1990
Medical*Online
荒川泰行ほか:慢性肝疾患における血清金属代謝異常の病態生理学的意義,Biomed Res Trace Elements 2:1,1991
Medical*Online
P.60 掲載の参考文献
Reding P,Duchateau J,Bataille C:Oral zinc supplementation improves hepatic encephalopathy.Results of randomized controlled trial.Lancet 2:493,1984
PubMed
Van der Rigt CC,Schaim SW,Schat H et al:Overt hepatic encephalopathy precipitated by zinc deficiency.Gastroenterology 100:1114,1991
 
Riggio O,Merli M,Capocaccia L:Zinc supplementation reduce blood ammonia and increases liver ornithin transcarbamirase activity in experimental cirrhosis.Hepatology 16:785,1992
 
Bresin G, Paisi G, Banti S:Management of hepatic encephalopathy with oral zinc supplementation.A long-term treatment.Her J Med 2:414,1993
 
Marchesini G,Fabri A,Bianchi G et al:Zinc supplementation and amino acid nitrogen metabolism in patients with advanced cirrhosis.Hepatology 23:1084,1996
 
片山和宏,大岡優子,吉川澄ほか:慢性肝疾患の窒素代謝における血中亜鉛の意義についての検討,肝臓 42:120,2001
 
Yoshida Y,Higashi T,Nouso K et al:Effects of zinc deficiency/zinc supplementation on ammonia metabolism in patients with decompensated liver cirrhosis.Acta Med Okayama 55:349,2001
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片山和宏:肝窒素代謝と亜鉛,治療(別冊) 87:68,2005
 
P.62 掲載の参考文献
Boyett JD,Sullivan JF:Zinc and collagen content of cirrhotic liver.Am J Dig Dis 15:797,1970
PubMed
Fernanndez-Madrid F,Prasad AS,Oberleas D:Effect of zinc deficiency on nucleic acids,collagen and noncollagen protein of the connective tissue.J Lab Clin Med 82:951,1973
 
McClain PE,Wiley ER,Beecher GR et al:Infuluence of zinc deficiency on synthesis and crosslinking of rat skin collagen.Biochem Biopys Acta 304:457,1973
 
Anttinen H,Ryhanen L,Puistola U et al:Decrease in liver collagen accumulation in carbon tetrachloride-injured and normal growing rats upon administration of zinc.Gastroenterology 86:532,1984
PubMed
Camps J,Bargallo T,Gimenez A et al:Relationship between hepatic lipid peroxidation and fibrogenesis in carbon tetrachloride-treated rats.:Effect of zinc admunistration.Clin Sci(Lond) 83:695,1992
PubMed
Cabre M,Ferre N,Folch J et al:Inhibition of hepatic cell nuclear DNA fragmentation by zinc in carbon tetrachloride-treated rats.J Hepatol 31:228,1999
PubMed
高松正剛ほか:慢性肝疾患に対する抗繊維化療法-亜鉛含有製剤による検討-,肝胆膵 48:659,2004
 
高松正剛,土細工利夫,廣岡大司:肝繊維化抑制と亜鉛,治療(別冊) 87:63,2005
 
高松正剛ほか:NAFLD治療における亜鉛療法の有益な効果,Ther Res 27:2119,2006
 
Takahashi M et al:Possible inhibitory effect of oral zinc supplementation on hepatic fibrosis through downregulation of TIMP-1:A pilot study.Hepatol Res 37:405,2007
PubMed
高松正剛ほか:高齢者における慢性肝疾患と亜鉛,老年消化器病 19:85,2007
 
Vallee BL,Wacker WEC et al:Zinc metabolism in hepatic dysfunction.II.Correlation of metabolic patterns with biochemical findings.New Eng J Med 257:1055,1957
 
Sullivan JF,Lankfold HG:Urinary excretion of zinc in alcoholism and postalcoholic cirrhosis.Am J Clin Nutr 10:153,1962
 
Helwig HL et al:Urinary and serum zinc levels in chronic alcoholism.Am J Clin Pathol 45:156,1966
PubMed
Sullivan JF et al:Zinc sulfate therapy in alcoholic cirrhosis.Gastroenterology 74:1155,1978
 
McDonald J T,Margen S:Wine versus ethanol in human nutrition.IV Zinc balance.Am J Clin Nutr 33:1096,1980
PubMed
Milman N et al:Zinc absorption in patients with compensated alcoholic cirrhosis.Scand J Gastroenterol 18:871,1983
PubMed
鈴木一幸ほか:アルコール症と微量元素,最新医学 45:662,1990
Medical*Online
P.63 掲載の参考文献
Ozgenc F et al:The influence of marginal zinc deficient diet on post-vaccination immune response against hepatitis B in rats.Hepatol Res 35:26,2006
PubMed
Abe M,Akbar F,Onji M:Zinc and hepatitis B virus vaccination.Hepatol Res 35:1,2006
 
P.65 掲載の参考文献
Nagamine T,Takagi H,Hashimoto Y et al:Therapeutic role of zinc and metallothioneine in the liver on the thrapeutic effect of IFN-α to hepatitis C patients.Biol Trace Elements Res 58:65,1997
 
Nagamine T,Takagi H et al:Preliminary study of combination therapy with interferon-α and zinc in chronic hepatitis C patients with genotype Ib.Biol Trace Elements Res 75:53,2000
 
Takagi H,Nagamine T,Abe T et al:Zinc supplementation enhances the response to interferon therapy in patients with chronic hepatitis C.J Viral Hepat 8:367,2001
PubMed
冨士原将之,上紺屋憲彦,坪井慶太ほか:亜鉛-カルノシン化合物による放射線誘発口腔粘膜障害予防の臨床評価,日本医学放射線学会誌 62:144,2001
 
大塚敏之ほか:C型慢性肝炎に対する亜鉛製剤を併用したインターフェロン再投与の治療成績,臨床と研究 79:029,2002
 
Wang SK,Chih HG,Guoo SWH et al:The effect of zinc supplementation on the treatment of chronic hepatitis C patients with interferon and ribavirin.Clin Biochem 38:614,2005
 
長嶺竹明:C型慢性肝炎と亜鉛,治療(別冊) 87:53,2005
 
川口雅功:C型慢性肝炎治療と亜鉛-インターフェロン治療における血球系副反応軽減効果-,治療(別冊) 87:58,2005
 
村上泰子,小薮智子ほか:C型慢性肝炎のPEGIFNα-2b/ribavirin併用療法における亜鉛投与のALT値改善効果(投与開始8週目までの検討).肝臓 47:165,2006
 
Moriyama M et al:Clinical significance of evaluation of serum zinc concentrations in C-viral chronic liver disease.Dig Dis Sci 51:1967,2006
 
中尾啓子ほか:C型慢性肝炎に対するPEG-IFN-α2aとポラプレジンク併用療法による血球と肝機能変化,日本病院薬剤師会雑誌 42:1307,2006
Medical*Online
石井邦英ほか:ペグインターフェロン・リバビリン併用療法時の口腔内症状に対するニザチジンの効果,Prog Med 27:1001,2007
Medical*Online
川口雅功ほか:C型慢性肝炎のインターフェロンα2b/リバビリン療法における血球減少に対する亜鉛補充の検討,肝胆膵 54:433,2007
Medical*Online
Murakami Y et al:Zinc supplementation presents the increase of transaminase in chronic hepalitis C patients during combination therapy with pegylated interferon α-2b and ribavirin.J Nutr Sci Vitaminol 53:213,2007
 
森山光彦ほか:C型肝炎と亜鉛,老年消化器病 19:79,2007
 
川口雅功ほか:C型慢性肝炎のインターフェロンα-2b/リバビリン療法における血球減少と亜鉛動態に関する検討,Ther Res 29:1187,2008
 
Nagamine T,Nakajima K et al:Induction of type I interferon receptor by zinc in U937 cells.Cytokine 46:436,2009
 
P.66 掲載の参考文献
Wright EB,Darmandy TL:Liver zinc in carcinoma.Nature 237:166,1972
 
Kew MC,Mallett RC:Hepatic zinc concentrations in primary cancer of he liver.Br J Cancer 29:80,1974
 
亀田幸男:肝細胞癌における肝組織亜鉛の動態と臨床的意義について,日本消化器病学会誌 80:2556,1983
 
宮田学ほか:原発性肝癌組織における微量金属元素-癌部と非癌部の比較,日本消化器病学会誌 83:2091,1986
 
Okuno T,Shimamura Y,Mizuno M,Miyata S,et al:Trace elements in hepatoma tissue.Trace Elements in Medicine 5:130,1988
 
Praoolsinsap C,Promvanit N,Komindr S et al:Serum metals in chronic viral hepatitis and hepatocellular carcinoma in Thailand.J Gastroenterol 29:610,1994
PubMed
Ohmoto K,Yamamoto S:Zinc metabolism after transcatheter arterial embolization for hepatocellular carcinoma.Hepato-Gastroenterol 45:1082,1998
 
Ebara M et al:Relationship between copper,zinc and metallothionein in hepatocellular carcinoma and its surrounding liver parenchyma.J Hepatol 33:415,2000
PubMed
Ebara M,Fukuda H et al:Metal contents in the liver of patients with chronic liver disease caused by hepatitis C virus.Reference to hepatocellular carcinoma.Oncology 65:323,2003
PubMed
P.67 掲載の参考文献
Fraser RM et al:Clinical trial of a new carbonoxolone analogue(BX24),zinc sulfate,and vitamine A in the treatment of gastric ulcer.Gut 13:459,1972
 
Frommer DJ:The healing of gastric ulcers by zinc sulfate.Med J Aust 2:793,1975
PubMed
Arakawa T,Satoh H,Nakamura A et al:Effects of zinc L-carnosine on gastric mucosal and cell damage caused by ethanol in rats.Dig Dis Sci 35:559,1990
 
Yoshikawa T,Naito Y,Tanigawa T et al:The antioxidant properties of a novel zinc-carnosine chelate compound,N-(3-aminopropionyl)-L-histidinato zinc.Biochim Biophys Acta 1115:15,1991
PubMed
三好秋馬,松尾裕,三輪剛ほか:胃潰瘍に対するZ-103の臨床的有用性の検討-塩酸セトラキサートを対照薬とした多施設二重盲検試験-,薬理と治療 20:199,1992
 
堀裕子,吉川敏一,米田智幸:亜鉛-カルノシン化合物(Z-103)のAAPH 誘発胃粘膜脂質過酸化反応に対する作用,医学のあゆみ 160:529,1992
 
Kuwayama H:Zinc compound is a novel,highly effective triple thrapy for eradication of Helicobacter pylori.Gastroenterology 111:A139,1995
 
北澤要,桑山肇:亜鉛と消化性潰瘍,医薬ジャーナル 33:135,1997
 
吉川敏一,八木信明ほか:NSAIDs粘膜障害における亜鉛,消化器の臨床 2:44,1999
 
竹内孝治,古川修,鵜川英樹:胃粘膜再生における亜鉛の作用機序,消化器の臨床 2:35,1999
 
大高道郎,小田嶋傑,三上健一郎ほか:消化器疾患と亜鉛-胃粘膜におけるHSP誘導作用を中心に-,治療(別冊) 67:41,2005
 
内藤裕二ほか:NSAIDs胃粘膜障害における亜鉛,老年消化器病 19:67,2007
 
大高道郎ほか:高齢者消化器疾患における亜鉛の重要性-亜鉛による消化管粘膜保護作用を含めて-,老年消化器病 19:73,2007
 
P.68 掲載の参考文献
Dronfield MW et al:Zinc nutrition in ulcerative colitis:A therapeutic trial and report on plasma levels.Gut 18:33,1977
 
Solomons NW,Rosenberg IH,Sandstead HH et al:Zinc deficiency in Crohn's disease.Digestion 16:87,1977
PubMed
Sturniolo MG et al:Mechanism for zinc deficiency in Crohn's disease. Gut 19:A443,1978
 
McClain C et al:Zinc deficiency:A complication of Crohn's disease.Gastroenterology 78:272,1980
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武田憲昭:亜鉛酵素「アンギオテンシン変換酵素」活性比と味覚障害患者の亜鉛栄養状態の評価,Biomed Res Trace Elements 20:149,2009
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Chang TL et al:Determination of magnesium and zinc in human brain tissue by atomic absorption spectrophotometry.Anal Chim Acta 34:17,1966
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Harrison WW et al:Trace elements in human brain;Copper,zinc,iron and magnesium.Clin Chim Acta 21:55,1968
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宮田学,亀山正邦:変性神経疾患における微量元素,神経内科 13:9,1980
 
宮尾益英:小児科領域における微量元素-特に銅および亜鉛について-,日本小児科学会誌 85:1271,1981
 
Fredrickson CJ:Neurobiology of zinc and zinc containing neuirons.Int Rev Neurobiol 31:145,1989
 
大石実,高須俊明:神経疾患と微量元素,最新医学 45:657,1990
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Frederickson CJ et al:Importance of zinc in the central nervous system;The zinc containing neuron. J Nutr 130:1471S,2000
 
Takeda A,Minami A,Oku N:Neuromodulatory action of zinc in the release of neurotransmitters. Biomed Res Trace Elements 14:287,2003
 
中山明弘ほか:ハーブエッセンシャルオイルの活性酸素種の消去能と生体反応,Aroma Res 18:123,2004
 
Maylor EA,Simpson EE,Secker DL et al:Effects of zinc supplementation on cognitive function in healthy middle-aged and older adults.Br J Nutr 96:752,2006
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Kimura K,Kumura J:Preliminary report on metabolism of trace elements in zinc in schizophrenics.Proc Jap Acad Sci 41:943,1965
 
Pffeifer CC,Iliev V:Zinc deficiency and copper excess in the schizophrenias.Int Rev Neurobiol (supple)1:141,1972
 
Greiner AC,Chan SC,Nicolson GA:Human brain contents of calcium,copper,magnesium,and zinc in some neurological pathologies.Clin Chim Acta 64:211,1975
PubMed
Henkin RI:A syndrome of acute zinc loss.Cerebellar dysfunction,mental changes,anorexia and smell dysfunction.Arch Neurol 32:745,1975
PubMed
Casper RC et al:An elevation of trace metals,vitamins and taste function in anorexia nervosa.Am J Clin Nutr 33:1801,1980
 
Hansen CR Jr et al:Copper and zinc deficiencies in association with depression and neurological fi ndings.Biol Psychiatry 18:395,1983
 
木村潔,久村静司,錦織壮:破瓜型分裂病に対するかき肉エキスの臨床効果(第一報),微量栄養素研究 2:153,1985
 
錦織壮ほか:破瓜型分裂病に対するかき肉エキスの臨床効果並びに亜鉛,銅代謝について(第二報),微量栄養素研究 3:79,1986
 
Nakai Y et al:Taste function in patients with anorexia nervosa and bulimia nervosa.International J Eating Disorders 6:257,1987
 
Nishigori T,Kimura K:Supplementary effect of oyster extract on depressed patients under treatment with antidepressants.Trace Nutrients Res 4:203,1988
 
McLoughlin IJ,Hodge SJ:Zinc in depressive disorder.Acta psychiatr Scand 82:451,1990
 
Andrews RCR:Unification of the findings in schizophrenia by reference to the effects of gestational zinc deficiency.Med Hypotheses 31:141,1990
 
Kornhuber J et al:Iron,copper,zinc,magnesium,and calcium in postmortem brain tissue from shizophrenic patients.Biol Psychiatry 36:31,1994
 
Maes M et al:Hypozincemia in depression.J Affect Disord 31:135,199494
 
Maes M,Vandoolaeghe E,Neels H et al:Lower serum zinc in major depression is a sensitive marker of treatment resistance and of the immune/inflammatory response in that illness.Biol Psychiatry 42:349,1997
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Maes M et al:Lower serum zinc in major depression in relation to changes in serum acute phase proteins.J Affect Disord 56:189,1990
 
Shay NF,Mangian HF:Neurobiology of zinc-influenced eating behavior.J Nutr 130:1493S,2000
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Nowak G et al:Effect of zinc supplementation on antidepressant therapy in unipolar depression;A preliminary placebo-controlled study.Pol J Pharmacol 55:1143,2003
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小野あゆみ,南豊彦,中川のぶ子ほか:味覚低下症例とうつ病,耳鼻と臨床 50:328,2004
 
Nowak G,Szewezyk B,Pilk A:Zinc and depression.An update.Pharmacological Reports 57:713,2005
 
大田共夫ほか:C型肝炎に併発し亜鉛補充療法が奏効した治療抵抗性うつ病の1症例, 臨床精神薬理 8:489,2005
 

第6章 老化と亜鉛

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Garry PJ et al:Nutritional status in a healthy elderly population;Dietary and supplemental intakes.Am J Clin Nutr 36:319,1982
 
Garfinkel D:Is aging inevitable?The intracellular zinc deficiency hypothesis of aging.Med Hypothesis 19:117,1986
 
山口賢次:加齢と微量元素,最新医学 45:753,1990
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Sandstead HH:Is zinc deficiency a public health problem?Nutrition 11:87,1995
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後藤真:遺伝性ヒト老化モデル-Werner症候群-,医学のあゆみ 188:80,1999
 
高橋良哉:微量元素と老化,Biomed Res Trace Elements 15:326,2004
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柳澤裕之:生命と微量元素-なぜ生体に微量元素は必要なのか-,治療 88:1839,2006
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荒川泰行ほか:高齢者と亜鉛,老年消化器病 19:53,2007
 
宮田學:高齢者の亜鉛欠乏症,日本老年医学会誌 44:677,2007
 
P.99 掲載の参考文献
Vikbladh I:Studies on zinc in blood.Scand J Clin Lab Invest 3:1,1951
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Pekarek RS et al:Serum zinc,iron and copper concentrations during typhoid fever in man;Effect of chloramphenicol therapy.Clin Chem 21:528,975
 
Bogden JD:Effect of pulmonary tuberculosis on blood concentrations of copper and zinc.Am J Clin Pathol 67:251,1977
PubMed
Duchateau J et al:Beneficial effects of oral zinc supplementation on the immune response of old people.Am J Med 70:1001,1981
PubMed
Allen JI et al:Alteration in human natural killer cell activity and monocyte cytotoxicity induced by zinc deficiency.J Lab Clin Med 102:577,1983
PubMed
関口隆憲:微量元素と易感染性,小児医学 25:267,1992
 
Losourd BM:Nutrition and immunity in the elderly:Modification of immune responses with nutritional treatments.Am J Clin Nutr 66:4785,1997
 
Shankar AH,Prasad AS:Zinc and immune function:The biological basis of altered resistance to infection.Am J Clin Nutr 68(suppl):447s,1998
 
Baum MK et al:Zinc status in human immunodeficiency viral infection.J Nutr 130:1421S,2000
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Prasad AS,Beck FWJ et al:Zinc supplementation decreases incidence of infections in the elderly:Effect of zinc on generation of cytokines and oxidative stress.Am J Clin Nutr 85:837,2007
PubMed
Ukita T,Oidov B et al:Serum zinc deficiency increases susceptibility to infection in older patients who have long-term hospitalizations.Biomed Res Trace Elements 19:260,2008
 
P.100 掲載の参考文献
Olson KB et al:Trace element content of cancerous and noncancerous human liver tissues.Science 119:772,1954
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Poswillo CE et al:Inhibition of carcinogenesis by dietary zinc.Nature 231:447,1956
 
Yamaguti H et al:Zinc metabolism in malignant tumor(1),Gann 51(Suppl):18,1960
 
三枝達明:担癌生体の亜鉛代謝に関する研究,大阪医誌 8:11,1966
 
高野喜久雄ほか:癌患者の血清銅および亜鉛について,癌の臨床 5:797,1969
 
白石忠雄ほか:亜鉛代謝に関する研究・消化器疾患および悪性腫瘍を中心として,日本内科学会誌 57:942,1968
 
Danielson A,Steinnes E:A study of some selected trace elements in normal and cancerous tissue by neutron activation analysis.J Nucl Med 11:260,1970
 
辻秀男ほか:担癌生体における亜鉛の意義,日本外科学会誌 71:1393,1970
 
Wright EB et al:Liver zinc in carcinoma.Nature 237:166,1972
PubMed
Alexander FW et al:Plasma copper and zinc in acute leukemia.Arch Dis Child 47:671,1972
PubMed
Dalves HT et al:Copper and zinc concentration in the plasma of leukemic children.Br J Haematol 24:525,1973
 
Griffith K et al:Tissue zinc in malignant disease.Nature 241:60,1973
PubMed
Pories WJ et al:Trace elements that act to inhibit neoplastic growth.Ann N.Y.Acad Sci 199:265,1977
 
Inutsuka S et al:Plasma copper and zinc levels in patients with malignant tumors of digestive organs.Cancer 42:626,1978
PubMed
Gregoriadis GC et al:A comparative study of trace elements in normal and cancerous colorectal tissues,Cancer 52:508,1983
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山本恵子:悪性腫瘍と微量元素,小児医学 25:251,1992
 
斉藤和雄:予防医学からみた微量元素-とくに成人病と微量元素-,Biomed Res Trace Elements 7:9,1996
 
小山洋:必須微量元素による発がん抑制効果とそのメカニズム,日本臨床 54:52,1996
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Ebara M, Fukuda H,Hatano R et al:Relationship between copper,zinc and metallothionein in hepatocellular carcinoma and its surrounding liver parenchyma.J Hepatol 33:415,2000
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Kuo HW,Chen SF,Wu CC et al:Serum and tissue trace elements in patients with breast cancer in Taiwan.Biol Trace Elem Res 89:1,2002
PubMed
Cunzhi H,Jiexian J et al:Serum and tissue levels of six trace elements and copper/zinc ratio in patients with cervical cancer and uterine myoma.Biol Trace Elem Res 94:113,2003
PubMed
福田浩之ほか:微量元素と癌,日本医師会雑誌 129:646,2003
 
荒川泰昭:癌免疫と微量元素,Biomed Res Trace Elements 15:317,2004
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江原正明,岡部真一郎ほか:肝細胞癌症例における銅蓄積の意義,Biomed Res Trace Elements 16:25,2005
Medical*Online
P.102 掲載の参考文献
Haumont S:Distribution of zinc in bone tissue.J Histochem Cytochem 9:141,1961
PubMed
Kenndy ED et al:Zinc.Its relationship to osteoporosis in rheumatoid arthritis.Scand J Rheumatol 4:243,1975
 
Brown ED et al:Bone mineralization during a developing zinc deficiency.Proc Soc Exp Biol Med 157:211,1978
PubMed
岡野登志夫:骨代謝回転に及ぼす必須微量元素の影響,日本臨床 54:148,1996
Medical*Online
山口正義:骨代謝調節における亜鉛の役割と機構-骨病態修復へのアプローチ-,Biomed Res Trace Elements 13:90,2002
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山口正義:骨代謝回転に及ぼす微量元素とその生体調節,治療 88:1964,2006
Medical*Online
P.104 掲載の参考文献
Mulholland JH et al:Protein metabolism and bedsores.Ann Surgery 118:1015,1943
 
Brewer RD et al:The effect of oral zinc sulphate on healing of decubitus ulcers in spinal cord injured patient.Ann Clin Spinal Cord Injured Conference 70:2,1967
 
Cohen C:Zinc sulphate and bedsores.Br Med J 2:561,1968
PubMed
Abbot DF et al:Zinc sulphate and bedsores.Br Med J 2:763,1968
 
Norris JR,Reynord RE:The effects of oral zinc sulphate thwrapy on decubitus ulcer.J Am Geriatr Soc 19:793,1971
 
McBean LD et al:Serun zinc and alpha2-macroglobulin concentration in myocardial infarction,decubitus ulcer,multiple myeloma,prostatic carcinoma,Down's syndrome and nephritic syndrome.Clin Chim Acta 50:43,1974
 
岡田淳:褥瘡患者における血清亜鉛の動態,微量金属代謝 1:43,1975
 
岡田淳,小酒井望,只野寿太郎ほか:硫酸亜鉛による褥瘡の治療,微量金属代謝 2:55,1976
 
清水幸雄,稲田潔:創傷治癒における亜鉛の意義,微量金属代謝 4:21,1977
 
William CM:Iron and zinc status in multiple sclerosis patients with pressure sores.Eur J Clin Nutr 42:321,1988
 
Chernoff RS et al:The effect of a very high protein liquid formula on decubitus ulcer healing in long-term tubefed institutionalized patients.J Am Dietetic Assoc 90:A-130,1990
 
Stephen J et al:Arginine stimulates wound healing and immune function in elderly human beings.Surgery 114:155,1993
 
田中結華,奥田豊子,福田みゆきほか:褥瘡を持つ寝たきり高齢者の栄養評価に関する研究,微量栄養素研究 16:165,1999
 
Kohn S et al:Effect of zinc supplementation on epidermal Langerhans' cells of elderly patients with decubitus ulcers.J Dermatol 27:258,2000
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Mino Y et al:Risk factors for pressure ulcers in bedridden elderly subjects:Importance of turning over in bed and serum albumin level.Geriatrics and gerontology 1:38,2001
 
田中芳明,ほか:創傷治癒促進因子を用いた褥瘡患者の栄養管理-2症例の治療報告.日本臨床外科学会雑誌 63:1633,2002
 
志越顕,上野ゆん子,熊谷頼佳:褥瘡と栄養検査-微量元素の重要性も含めて-,臨床病理レビュー 127:92,2003
 
湧上聖:褥瘡と亜鉛,治療(別冊) 87:88,2005
 
石澤美保子,奥田豊子,阿曽洋子:褥瘡患者における食事摂取内容・亜鉛摂取量と創治癒状況との関連,日本褥瘡学会誌 8:133,2006
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美濃良夫:褥瘡治療と栄養管理,医学のあゆみ 18:543,2006
 
P.107 掲載の参考文献
Goodwin JS et al:Association between nutritional status and cognitive functioning in a healthy population.JAMA 249:2917,1983
 
Prohaska JR:Functions of trace elements in brain metabolism.Physiol Rev 67:858,1987
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Tucker DM et al:Nutrition status and brain function in aging.Am J Clin Nutr 52:93,1990
PubMed
Uchida Y et al:The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein?like protein.Neuron 7:337,1991
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Bush AI et al:Rapid induction of Alzheimer A βamyloid formation by zinc.Science 265:1464,1994
 
川原正博,黒田洋一郎:アルツハイマー病と微量金属,老年精神医学 6:1105,1995
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Lovell MA et al:Protection against amyloid beta peptide toxicity by zinc.Brain Res 823:88,1999
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Huang X et al:Alzheimer's disease,β-amyloid protein and zinc.J Nutr 130:1488S,2000
 
Saito T,Kurosaki M,Numata T et al:Zinc and functional impairment of the brain associated with aging. Biomed Res Trace Elements 12:179,2001
 
石原良子ほか:細胞内金属元素の分布異常からみた神経細胞の変性-アルツハイマー病を例として-,Biomed Res Trace Elements 14:204,2003
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Morris MC,Evans DA et al:Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease.Arch Neurol 60:940,2003
 
Stoltenberg M et al:Immersion autometallographic tracing of zinc ions in Alzheimer β-amyloid plaques.Histochem Cell Biol 123:605,2005
 
Adrlard PA,Bush AI:Metals and Alzheimer's disease.J Alzheimers Dis 10:145,2006
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Maylor EA,Simpson EE,Secker DL et al:Effects of zinc supplementation on cognitive function in healthy middle-aged and older adults.Br J Nutr 96:752,2006
PubMed
Kawahara M:Neurotoxicity of trace elements and the pathogenesis of senile-type dementia.Biomed Res Trace Elements 19:25,2008
 
Bahnham KJ,Bush AI:Metals in Alzheimer's and Parkinson's disease.Curr Opin Chem Biol 12:222,2008
 
橋本道男,山下一也:食事で防ぐ認知症-特に魚摂取との関連-,最新精神医学 13:75,2008
 
橋本道男:アルツハイマー病と食事栄養,Trace Nutrients Research 25:8,2008
 
宮嶋裕明:神経変性病における微量金属の役割,細胞工学 27:246,2008
 

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