新生児低体温療法　実践マニュアル

出版社： 東京医学社
著者：
発行日： 2011-05-10
分野： 臨床医学：内科  >  小児科学一般
ISBN： 9784885632013
電子書籍版： 2011-05-10 （第1版第1刷）
書籍・雑誌
≪全国送料無料でお届け≫
品切れ

2,860 円(税込)

電子書籍
章別単位での購入はできません
ブラウザ、アプリ閲覧

2,860 円(税込)

購入する

商品紹介

CONSENSUS 2010に基づく新生児の低体温療法の実施法を網羅した手引書。国際標準のプロトコールによる具体的な手順や手技を、具体例を豊富に交えてわかりやすく解説する。

目次

  • 新生児低体温療法　実践マニュアル

    ―目次―

    1．プロローグ
    　この本のねらい
    　この本で使われている略語と専門用語

    2．総論
    　1）新生児における低体温療法の歴史
    　2）HIEの病態生理と低体温による脳保護のメカニズム
    　3）低体温に対する生理的反応と合併症

    3．マニュアル─基本編
    　1）現在の臨床エビデンスとガイドライン
    　2）低体温療法を施行する施設の条件
    　3）低体温療法の適応基準と除外基準　基本編1
    　　　─新生児HIEの診断の基本
    　4）低体温療法の適応基準と除外基準　基本編2
    　　　─適応基準の基本的な考え方
    　5）低体温療法の適応基準と除外基準　実践編
    　　　─2010 CoSTRに基づく適応基準
    　6）aEEGと標準脳波　基本編
    　7）aEEGと標準脳波　応用編
    　　　─低体温療法の適応基準としてのaEEG
    　8）低体温療法施行中のモニタリング
    　9）低体温療法の導入と維持─全身冷却と選択的頭部冷却の特徴
    　10）低体温療法導入の実際─選択的頭部冷却の場合
    　11）低体温療法導入の実際─全身冷却の場合
    　12）冷却維持期のモニタリングと検査
    　13）低体温療法中の内科管理─併用薬物療法
    　14）低体温療法中の内科管理─呼吸循環管理
    　15）低体温療法中の内科管理─輸液・電解質管理
    　16）低体温療法中の内科管理─その他
    　17）復温方法の実際
    　18）画像検査
    　19）HIE児のフォローアップ

    4．マニュアル─実例編
    　1）北米　コーネル大学ニューヨークプレスビテリアン病院の場合
    　2) 英国　ロンドン大学UCL校周産期病院の場合
    　3）日本　淀川キリスト教病院の場合

    5．まとめ
    　1）わが国における問題点と今後の展望
    　2）より効果的な低体温療法を求めて─今後の動向
    　3）導入基準やプロトコール変更の手順
    　4）低体温療法をめぐる倫理的課題

    付録
    　1　日本版ガイドライン骨子
    　2　エントリー基準フローチャート
    　3　バイタルサインチェック用紙
    　4　レジストリー チェックシート

この書籍の参考文献

参考文献のリンクは、リンク先の都合等により正しく表示されない場合がありますので、あらかじめご了承下さい。

本参考文献は電子書籍掲載内容を元にしております。

2. 総論

P.14 掲載の参考文献
・ Kshettry VR, Mindea SA, Batjer HH. The management of cranial injuries in antiquity and beyond. Neurosurg Focus 2007 ; 23 : E8.
PubMed
・ Wyatt JS, Thoresen M. Hypothermia treatment and the newborn. Pediatrics 1997 ; 100 : 1028-1030.
PubMed
・ Westin B, Nyberg R, Miller JA Jr, et al. Hypothermia and transfusion with oxygenated blood in the treatment of asphyxia neonatorum. Acta Paediatr Suppl 1962 ; 139 : 1-80.
PubMed
・ Silverman WA, Fertig JW, Berger AP. The influence of the thermal environment upon the survival of newly born premature infants. Pediatrics 1958 ; 22 : 876-886.
PubMed
・ Silverman WA, Parke PC. The newborn. Keep him warm. Am J Nurs 1965 ; 65 : 81-84.
PubMed
・ Edwards AD, Brocklehurst P, Gunn AJ, et al. Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy : synthesis and meta-analysis of trial data. BMJ 2010 ; 340 : c363.
PubMed
・ Bernard S. Hypothermia after cardiac arrest : expanding the therapeutic scope. Crit Care Med 2009 ; 37 : S227-S233.
PubMed
・ Iwata O, Iwata S. Filling the evidence gap : How can we improve the outcome of neonatal encephalopathy in the next 10 years? Brain Dev 2011 ; 33 : 221-228.
PubMed
・ Perlman JM, Wyllie J, Kattwinkel J, et al. Part 11 : Neonatal resuscitation : 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation 2010 ; 122 : S516-S538.
PubMed
P.17 掲載の参考文献
・ Azzopardi D, Strohm B. Temperature control during therapeutic moderate whole-body hypothermia for neonatal encephalopathy. Arch Dis Child Fetal Neonatal Ed 2010 ; 95 : F373-F375.
PubMed
・ Iwata O, Iwata S, Thornton JS, et al. "Therapeutic time window" duration decreases with increasing severity of cerebral hypoxia-ischaemia under normothermia and delayed hypothermia in newborn piglets. Brain Res 2007 ; 1154 : 173-180.
PubMed
・ Kristian T. Metabolic stages, mitochondria and calcium in hypoxic/ischemic brain damage. Cell Calcium 2004 ; 36 : 221-233.
PubMed
・ Volpe JJ. Hypoxic-ischemic encephalopathy. In : Neurology of Newborn, Philadelphia, Saunders, 2008, p245-480.
 
・ Northington FJ, Ferriero DM, Flock DL, et al. Delayed neurodegeneration in neonatal rat thalamus after hypoxia-ischemia is apoptosis. J Neurosci 2001 ; 21 : 1931-1938.
PubMed
P.20 掲載の参考文献
・ Erecinska M, Thoresen M, Silver IA. Effects of hypothermia on energy metabolism in Mammalian central nervous system. J Cereb Blood Flow Metab 2003 ; 23 : 513-530.
PubMed
・ Gupta AK, Al Rawi PG, Hutchinson PJ, et al. Effect of hypothermia on brain tissue oxygenation in patients with severe head injury. Br J Anaesth 2002 ; 88 : 188-192.
PubMed
・ Iwata O, Iwata S. Filling the evidence gap : How can we improve the outcome of neonatal encephalopathy in the next 10 years? Brain Dev 2011 ; 33 : 221-228.
PubMed
・ Sarkar S, Barks JD. Systemic complications and hypothermia. Semin Fetal Neonatal Med 2010 ; 15 : 270-275.
PubMed
・ Schubert A. Side effects of mild hypothermia. J Neurosurg Anesthesiol 1995 ; 7 : 139-147.
PubMed
P.21 掲載の参考文献
・ Gunn AJ, Thoresen M. Hypothermic neuroprotection. NeuroRx 2006 ; 3 : 154-169.
PubMed
・ Sakoh M, Gjedde A. Neuroprotection in hypothermia linked to redistribution of oxygen in brain. Am J Physiol Heart Circ Physiol 2003 ; 285 : H17-H25.
 
・ Iwata O, Thornton JS, Sellwood MW, et al. Depth of delayed cooling alters neuroprotection pattern after hypoxia-ischemia. Ann Neurol 2005 ; 58 : 75-87.
PubMed

3. マニュアル - 基本編

P.25 掲載の参考文献
・ Azzopardi DV, Strohm B, Edwards AD, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med 2009 ; 361 : 1349-1358.
PubMed
・ Eicher DJ, Wagner CL, Katikaneni LP, et al. Moderate hypothermia in neonatal encephalopathy : efficacy outcomes. Pediatr Neurol 2005 ; 32 : 11-17.
PubMed
・ Shankaran S, Laptook AR, Ehrenkranz RA, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 2005 ; 353 : 1574-1584.
PubMed
・ Simbruner G, Mittal RA, Rohlmann F, et al. Systemic hypothermia after neonatal encephalopathy : outcomes of neo.nEURO.network RCT. Pediatrics 2010 ; 126 : e771-e778.
PubMed
・ Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy : multicentre randomised trial. Lancet 2005 ; 365 : 663-670.
PubMed
・ Lin ZL, Yu HM, Lin J, et al. Mild hypothermia via selective head cooling as neuroprotective therapy in term neonates with perinatal asphyxia : an experience from a single neonatal intensive care unit. J Perinatol 2006 ; 26 : 180-184.
PubMed
・ Zhou WH, Cheng GQ, Shao XM, et al. Selective head cooling with mild systemic hypothermia after neonatal hypoxic-ischemic encephalopathy : a multicenter randomized controlled trial in China. J Pediatr 2010 ; 157 : 367-372.
 
・ Edwards AD, Brocklehurst P, Gunn AJ, et al. Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy : synthesis and meta-analysis of trial data. BMJ 2010 ; 340 : c363.
PubMed
・ Perlman JM, Wyllie J, Kattwinkel J, et al. Part 11 : Neonatal resuscitation : 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation 2010 ; 122 : S516-S538.
PubMed
・ 日本蘇生協議会NCPRガイドライン. http://jrc.umin.ac.jp.
 
P.27 掲載の参考文献
・ Perlman JM, Wyllie J, Kattwinkel J, et al. Part 11 : Neonatal resuscitation : 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation 2010 ; 122 : S516-S538.
PubMed
P.29 掲載の参考文献
・ Nelson KB, Leviton A. How much of neonatal encephalopathy is due to birth asphyxia? Am J Dis Child 1991 ; 145 (11) : 1325-1331.
PubMed
・ King TA, Jackson GL, Josey AS, et al. The effect of profound umbilical artery acidemia in term neonates admitted to a newborn nursery. J Pediatr 1998 ; 132 (4) : 624-629.
PubMed
・ Jain L, Ferre C, Vidyasagar D, et al. Cardiopulmonary resuscitation of apparently stillborn infants : survival and long-term outcome. J Pediatr 1991 ; 118 (5) : 778-782.
PubMed
・ Nelson KB, Ellenberg JH. Apgar scores as predictors of chronic neurologic disability. Pediatrics 1981 ; 68 (1) : 36-44.
PubMed
・ Ferriero DM. Neonatal brain injury. N Engl J Med 2004 ; 351 (19) : 1985-1995.
 
・ Volpe JJ. Neurology of the Newborn, 5th ed, Philadelphia, PA, Saunders, 2008.
 
P.31 掲載の参考文献
・ Azzopardi DV, Strohm B, Edwards AD, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med 2009 ; 361 (14) : 1349-1358.
PubMed
・ Shankaran S, Laptook AR, Ehrenkranz RA, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 2005 ; 353 (15) : 1574-1584.
PubMed
・ Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy : multicentre randomised trial. Lancet 2005 ; 365 (9460) : 663-670.
PubMed
P.36 掲載の参考文献
・ Azzopardi DV, Strohm B, Edwards AD, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med 2009 ; 361 (14) : 1349-1358.
PubMed
・ Shankaran S, Laptook AR, Ehrenkranz RA, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 2005 ; 353 (15) : 1574-1584.
PubMed
・ Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy : multicentre randomised trial. Lancet 2005 ; 365 (9460) : 663-670.
PubMed
・ Sarnat HB, Sarnat MS. Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study. Arch Neurol 1976 ; 33 : 696-705.
PubMed
・ Volpe JJ. Neurology of the Newborn. 5th ed, Philadelphia, PA, Saunders, 2008.
 
P.37 掲載の参考文献
・ Battin MR, Dezoete JA, Gunn TR, et al. Neurodevelopmental outcome of infants treated with head cooling and mild hypothermia after perinatal asphyxia. Pediatrics 2001 ; 107 : 480-484.
PubMed
・ Levene MI, Sands C, Grindulis H, et al. Comparison of two methods of predicting outcome in perinatal asphyxia. Lancet 1986 ; 1 : 67-69.
PubMed
・ ACOG. Neonatal Encephalopathy and Cerebral Palsy, Washington, DC, 2003.
 
・ Azzopardi DV, Strohm B, Edwards AD, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med 2009 ; 361 : 1349-1358.
PubMed
・ Shankaran S, Laptook AR, Ehrenkranz RA, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 2005 ; 353 : 1574-1584.
PubMed
・ Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy : multicentre randomised trial. Lancet 2005 ; 365 : 663-670.
PubMed
P.41 掲載の参考文献
・ Hellstrom-Westas L, Rosen I. Continuous brain-function monitoring : state of the art in clinical practice. Semin Fetal Neonatal Med 2006 ; 11 : 503-511.
PubMed
・ Shellhaas RA, Clancy RR. Characterization of neonatal seizures by conventional EEG and single-channel EEG. Clin Neurophysiol 2007 ; 118 (10) : 2156-2161.
PubMed
P.46 掲載の参考文献
・ Shalak LF, Laptook AR, Velaphi SC, et al. Amplitude-integrated electroencephalography coupled with an early neurologic examination enhances prediction of term infants at risk for persistent encephalopathy. Pediatrics 2003 ; 111 (2) : 351-357.
PubMed
・ Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy : multicentre randomised trial. Lancet 2005 ; 365 (9460) : 663-670.
PubMed
・ al Naqeeb N, Edwards AD, Cowan FM, et al. Assessment of neonatal encephalopathy by amplitude-integrated electroencephalography. Pediatrics 1999 ; 103 (6 Pt 1) : 1263-1271.
 
P.47 掲載の参考文献
・ de Vries LS, Toet MC. Amplitude integrated electroencephalography in the full-term newborn. Clin Perinatol 2006 ; 33 (3) : 619-632, vi.
PubMed
・ Spitzmiller RE, Phillips T, Meinzen-Derr J, et al. Amplitude-integrated EEG is useful in predicting neurodevelopmental outcome in full-term infants with hypoxic-ischemic encephalopathy : a meta-analysis. J Child Neurol 2007 ; 22 (9) : 1069-1078.
PubMed
・ Osredkar D, Toet MC, van Rooij LG, et al. Sleep-wake cycling on amplitude-integrated electroencephalography in term newborns with hypoxic-ischemic encephalopathy. Pediatrics 2005 ; 115 (2) : 327-332.
PubMed
・ Takenouchi T, Rubens EO, Yap VL, et al. Delayed onset of sleep-wake cycling with favorable outcome in hypothermic-treated neonates with encephalopathy. J Pediatr 2011 (in press).
 
P.52 掲載の参考文献
・ Azzopardi D. Whole Body Hypothermia for the Treatment of Perinatal Asphyxial Encephalopathy. http://www.npeu.ox.ac.uk/Toby/
 
・ Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy : multicentre randomised trial. Lancet 2005 ; 365 : 663-670.
PubMed
・ Iwata O, Iwata S, Tamura M, et al. Brain temperature in newborn piglets under selective head cooling with minimal systemic hypothermia. Pediatr Int 2003 ; 45 : 163-168.
PubMed
・ Iwata S, Iwata O, Thornton JS, et al. Superficial brain is cooler in small piglets: neonatal hypothermia implications. Ann Neurol 2006 ; 60 : 578-585.
PubMed
・ Shankaran S, Laptook AR, Ehrenkranz RA, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 2005 ; 353 : 1574-1584.
PubMed
・ Azzopardi D. Whole Body Hypothermia for the Treatment of Perinatal Asphyxial Encephalopathy. http://www.npeu.ox.ac.uk/Toby/
 
・ Shankaran S, Laptook AR, Ehrenkranz RA, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 2005 ; 353 : 1574-1584.
PubMed
P.53 掲載の参考文献
・ Iwata O, Iwata S. Filling the evidence gap : How can we improve the outcome of neonatal encephalopathy in the next 10 years? Brain Dev 2011 ; 33（3）: 221-228.
PubMed
P.57 掲載の参考文献
・ Albaghdadi AS, Brooks LA, Pretorius AM, et al. Perfluorocarbon induced intra-arrest hypothermia does not improve survival in a swine model of asphyxial cardiac arrest. Resuscitation 2010, 81 : 353-358.
PubMed
・ Azzopardi D. Whole Body Hypothermia for the Treatment of Perinatal Asphyxial Encephalopathy. http://www.npeu.ox.ac.uk/Toby/
 
・ Bernard S. Hypothermia after cardiac arrest : expanding the therapeutic scope. Crit Care Med 2009 ; 37 : S227-S233.
PubMed
・ Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy : multicentre randomised trial. Lancet 2005, 365 : 663-670.
PubMed
P.61 掲載の参考文献
・ Gunn AJ. Cerebral hypothermia for prevention of brain injury following perinatal asphyxia. Curr Opin Pediatr 2000 ; 12 (2) : 111-115.
PubMed
・ Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy : multicentre randomised trial. Lancet 2005 ; 365 (9460) : 663-670.
PubMed
・ Takenouchi T, Cuaycong M, Ross G, et al. Chain of Brain Preservation-a concept to facilitate early identification and initiation of hypothermia to infants at high risk for brain injury. Resuscitation 2010 ; 81 (12) : 1637-1641.
PubMed
P.66 掲載の参考文献
・ Azzopardi D. Whole Body Hypothermia for the Treatment of Perinatal Asphyxial Encephalopathy. http://www.npeu.ox.ac.uk/Toby/
 
・ Azzopardi DV, Strohm B, Edwards AD, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med 2009 ; 361 : 1349-1358.
PubMed
・ Eicher DJ, Wagner CL, Katikaneni LP, et al. Moderate hypothermia in neonatal encephalopathy : safety outcomes. Pediatr Neurol 2005 ; 32 : 18-24.
PubMed
・ Iwata S, Iwata O, Thornton JS, et al. Superficial brain is cooler in small piglets : neonatal hypothermia implications. Ann Neurol 2006 ; 60 : 578-585.
PubMed
・ Shankaran S, Laptook AR, Ehrenkranz RA, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 2005 ; 353 : 1574-1584.
PubMed
P.67 掲載の参考文献
・ Eicher DJ, Wagner CL, Katikaneni LP, et al. Moderate hypothermia in neonatal encephalopathy : safety outcomes. Pediatr Neurol 2005 ; 32 : 18-24.
PubMed
・ Kendall GS, Kapetanakis A, Ratnavel N, et al. Passive cooling for initiation of therapeutic hypothermia in neonatal encephalopathy. Arch Dis Child Fetal Neonatal Ed 2010 ; 95 : F408-F412.
PubMed
P.70 掲載の参考文献
・ Azzopardi D, Edwards AD. Magnetic resonance biomarkers of neuroprotective effects in infants with hypoxic ischemic encephalopathy. Semin Fetal Neonatal Med 2010 ; 15 : 261-269.
PubMed
・ Bennet L, Booth L, Gunn AJ. Potential biomarkers for hypoxic-ischemic encephalopathy. Semin Fetal Neonatal Med 2010 ; 15 : 253-260.
PubMed
・ Ilves P, Lintrop M, Metsvaht T, et al. Cerebral blood-flow velocities in predicting outcome of asphyxiated newborn infants. Acta Paediatr 2004 ; 93 : 523-528.
PubMed
P.74 掲載の参考文献
・ Cilio MR, Ferriero DM. Synergistic neuroprotective therapies with hypothermia. Semin Fetal Neonatal Med 2010 ; 15 : 293-298.
PubMed
・ Iwata O, Iwata S. Filling the evidence gap : How can we improve the outcome of neonatal encephalopathy in the next 10 years? Brain Dev 2011 ; 33 : 221-228.
PubMed
・ O'brien FE, Iwata O, Thornton JS, et al. Delayed whole-body cooling to 33 or 35 degrees C and the development of impaired energy generation consequential to transient cerebral hypoxia-ischemia in the newborn piglet. Pediatrics 2006 ; 117 : 1549-1559.
PubMed
・ Sankar R, Painter MJ. Neonatal seizures : after all these years we still love what doesn't work. Neurology 2005 ; 64 : 776-777.
PubMed
P.75 掲載の参考文献
・ Gladstone DJ, Black SE, Hakim AM. Toward wisdom from failure : lessons from neuroprotective stroke trials and new therapeutic directions. Stroke 2002 ; 33 : 2123-2136.
PubMed
・ Macleod MR, Fisher M, O'collins V, et al. Good laboratory practice : preventing introduction of bias at the bench. Stroke 2009 ; 40 : e50-e52.
 
・ Robertson NJ, Iwata O. Bench to bedside strategies for optimizing neuroprotection following perinatal hypoxia-ischaemia in high and low resource settings. Early Hum Dev 2007 ; 83 : 801-811.
PubMed
・ Fukuda A. Diuretic soothes seizures in newborns. Nat Med 2005 ; 11 : 1153-1154.
PubMed
・ Sankar R, Painter MJ. Neonatal seizures : after all these years we still love what doesn't work. Neurology 2005 ; 64 : 776-777.
PubMed
P.80 掲載の参考文献
・ Azzopardi DV, Strohm B, Edwards AD, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med 2009 ; 361 : 1349-1358.
PubMed
・ Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy : multicentre randomised trial. Lancet 2005 ; 365 : 663-670.
PubMed
・ Shankaran S, Laptook AR, Ehrenkranz RA, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 2005 ; 353 : 1574-1584.
PubMed
・ Thoresen M, Whitelaw A. Cardiovascular changes during mild therapeutic hypothermia and rewarming in infants with hypoxic-ischemic encephalopathy. Pediatrics 2000 ; 106 : 92-99.
PubMed
・ Bacher A. Effects of body temperature on blood gases. Intensive Care Med 2005 ; 31 : 24-27.
PubMed
・ Markowitz SD, Mendoza-Paredes A, Liu H, et al. Response of brain oxygenation and metabolism to deep hypothermic circulatory arrest in newborn piglets : comparison of pH-stat and alpha-stat strategies. Ann Thorac Surg 2007 ; 84 : 170-176.
PubMed
・ Pirzadeh A, Schears G, Pastuszko P, et al. Effect of deep hypothermic circulatory arrest followed by low-flow cardiopulmonary bypass on brain metabolism in newborn piglets : Comparison of pH-stat and alpha-stat management. Pediatr Crit Care Med 2010.
 
・ Yamada Y, Kyuno T, Suzuki S, et al. A drop in gas temperature in the external part of the endotracheal tube is problematic during neonatal respiratory support. Pediatr Pulmonol 2008 ; 43 : 666-673.
 
P.81 掲載の参考文献
・ Azzopardi DV, Strohm B, Edwards AD, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med 2009 ; 361 : 1349-1358.
PubMed
・ Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy : multicentre randomised trial. Lancet 2005 ; 365 : 663-670.
PubMed
・ Shankaran S, Laptook AR, Ehrenkranz RA, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 2005 ; 353 : 1574-1584.
PubMed
・ Bacher A. Effects of body temperature on blood gases. Intensive Care Med 2005 ; 31 : 24-27.
PubMed
・ Markowitz SD, Mendoza-Paredes A, Liu H, et al. Response of brain oxygenation and metabolism to deep hypothermic circulatory arrest in newborn piglets : comparison of pH-stat and alpha-stat strategies. Ann Thorac Surg 2007 ; 84 : 170-176.
PubMed
・ Pirzadeh A, Schears G, Pastuszko P, et al. Effect of deep hypothermic circulatory arrest followed by low-flow cardiopulmonary bypass on brain metabolism in newborn piglets : Comparison of pH-stat and alpha-stat management. Pediatr Crit Care Med 2010. (Epub ahead of print)
 
・ Pillow JJ, Hillman NH, Polglase GR, et al. Oxygen, temperature and humidity of inspired gases and their influences on airway and lung tissue in near-term lambs. Intensive Care Med 2009 ; 35 : 2157-2163.
PubMed
・ Yamada Y, Kyuno T, Suzuki S, et al. A drop in gas temperature in the external part of the endotracheal tube is problematic during neonatal respiratory support. Pediatr Pulmonol 2008 ; 43 : 666-673.
 
P.83 掲載の参考文献
・ Azzopardi D. Whole Body Hypothermia for the Treatment of Perinatal Asphyxial Encephalopathy. http://www.npeu.ox.ac.uk/Toby/
 
・ Perlman JM, Wyllie J, Kattwinkel J, et al. Neonatal resuscitation : 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. Pediatrics 2010 ; 126 : e1319-e1344.
PubMed
・ Sarkar S, Barks JD. Systemic complications and hypothermia. Semin Fetal Neonatal Med 2010 ; 15 : 270-275.
PubMed
・ Volpe JJ. Hypoxic-ischemic encephalopathy. In : Neurology of Newborn, Philadelphia, Saunders Elsevier, 2008, p245-480.
 
P.84 掲載の参考文献
・ Fusch C, Bauer K, Bohles HJ, et al. Neonatology/Paediatrics-Guidelines on Parenteral Nutrition, Chapter 13. Ger Med Sci 2009 ; 7 : Doc15.
PubMed
・ Perlman JM, Wyllie J, Kattwinkel J, et al. Neonatal resuscitation : 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. Pediatrics 2010 ; 126 : e1319-e1344.
PubMed
・ Sarkar S, Barks JD. Systemic complications and hypothermia. Semin Fetal Neonatal Med 2010 ; 15 : 270-275.
PubMed
P.85 掲載の参考文献
・ 中瀬惇. 新版K 式発達検査にもとづく発達研究の方法-操作的定義による発達測定, ナカニシヤ出版, 京都, 2005.
 
・ Pearson ウェブサイト : http://www.psychcorp.co.uk/Home.aspx (Edwards et al., 2010)
 
・ Edwards AD, Brocklehurst P, Gunn AJ, et al. Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy : synthesis and meta-analysis of trial data. BMJ 2010 ; 340 : c363.
PubMed
・ Woodward LJ, Anderson PJ, Austin NC, et al. Neonatal MRI to predict neurodevelopmental outcomes in preterm infants. N Engl J Med 2006 ; 355 : 685-694.
PubMed
P.87 掲載の参考文献
・ Azzopardi D. Whole Body Hypothermia for the Treatment of Perinatal Asphyxial Encephalopathy. http://www.npeu.ox.ac.uk/Toby/
 
・ Azzopardi DV, Strohm B, Edwards AD, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med 2009 ; 361 : 1349-1358.
PubMed
・ Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy : multicentre randomised trial. Lancet 2005 ; 365 : 663-670.
PubMed
・ Shankaran S, Laptook AR, Ehrenkranz RA, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 2005 ; 353 : 1574-1584.
PubMed
P.91 掲載の参考文献
・ Azzopardi D. Whole Body Hypothermia for the Treatment of Perinatal Asphyxial Encephalopathy. http://www.npeu.ox.ac.uk/Toby/
 
・ Azzopardi, D, Edwards AD. Magnetic resonance biomarkers of neuroprotective effects in infants with hypoxic ischemic encephalopathy. Semin Fetal Neonatal Med 2010 ; 15 : 261-269.
PubMed
・ Iwata S, Bainbridge A, Nakamura T, et al. Subtle white matter injury is common in term-born infants with a wide range of risks. Int J Dev Neurosci 2010 ; 28 : 573-580.
PubMed
・ Thayyil S, Chandrasekaran M, Taylor A, et al. Cerebral magnetic resonance biomarkers in neonatal encephalopathy : a meta-analysis. Pediatrics 2010 ; 125 : e382-e395.
PubMed
・ Thornton JS, Ordidge RJ, Penrice J, et al. Temporal and anatomical variations of brain water apparent diffusion coefficient in perinatal cerebral hypoxic-ischemic injury : relationships to cerebral energy metabolism. Magn Reson Med 1998 ; 39 : 920-927.
PubMed
・ Barkovich AJ, Miller SP, Bartha A, et al. MR imaging, MR spectroscopy, and diffusion tensor imaging of sequential studies in neonates with encephalopathy. AJNR Am J Neuroradiol 2006 ; 27 : 533-547.
PubMed
P.93 掲載の参考文献
・ Robertson NJ, Cox IJ. Magnetic resonance spectroscopy of the neonatal brain. In : Rutherford M ed. MRI of the Neonatal Brain, London, WB Saunders, 2002, p295-313.
 
・ Thayyil S, Chandrasekaran M, Taylor A, et al. Cerebral magnetic resonance biomarkers in neonatal encephalopathy : a meta-analysis. Pediatrics 2010 ; 125 : e382-e395.
PubMed
・ Thornton JS, Cady EB, Shanmugalingam S, et al. Cerebral Temperature Mapping by Magnetic Resonance Spectroscopy in a Model of Total Body and Selective Head Cooling. Pediatric Research 2005 ; 57 (abstract).
 
・ Wyatt JS, Robertson NJ. Time for a cool head-neuroprotection becomes a reality. Early Hum Dev 2005 ; 81 : 5-11.
PubMed
P.95 掲載の参考文献
・ 三科潤, 河野由美. 厚生労働科学研究「周産期ネットワーク : フォローアップ研究」班 ハイリスク児のフォローアップマニュアル 小さく生まれた子どもたちへの支援, メジカルビュー社, 東京, 2007.
 
・ Edwards AD, Brocklehurst P, Gunn AJ, et al. Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy : synthesis and meta-analysis of trial data. BMJ 2010 ; 340 : c363.
PubMed
・ Perlman JM, Wyllie J, Kattwinkel J, et al. Part 11 : Neonatal resuscitation : 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation 2010 ; 122 : S516-S538.
PubMed

5. まとめ

P.113 掲載の参考文献
・ Iwata O, Iwata S. Filling the evidence gap : How can we improve the outcome of neonatal encephalopathy in the next 10 years? Brain Dev 2011 ; 33 : 221-228.
PubMed
・ Nabetani M, Takenouchi T, Iwata O, et al. A Nation-wide Survey on Therapeutic Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy in Japan. In : Hot Topics in Neonatology, Washington DC, 2010 (abstract).
 
・ Perlman JM, Wyllie J, Kattwinkel J, et al. Part 11 : Neonatal resuscitation : 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation 2010 ; 122 : S516-S538.
PubMed
P.116 掲載の参考文献
・ Eicher DJ, Wagner CL, Katikaneni LP, et al. Moderate hypothermia in neonatal encephalopathy : efficacy outcomes. Pediatr Neurol 2005 ; 32 : 11-17.
PubMed
・ Lee BS, Woo CW, Kim ST, et al. Long-term neuroprotective effect of postischemic hypothermia in a neonatal rat model of severe hypoxic ischemic encephalopathy : a comparative study on the duration and depth of hypothermia. Pediatr Res 2010 ; 68 : 303-308.
 
・ Schubert S, Brandl U, Brodhun M, et al. Neuroprotective effects of topiramate after hypoxia-ischemia in newborn piglets. Brain Res 2005 ; 1058 : 129-136.
PubMed
・ Meyn DF Jr, Ness J, Ambalavanan N, et al. Prophylactic phenobarbital and whole-body cooling for neonatal hypoxic-ischemic encephalopathy. J Pediatr 2010 ; 157 : 334-336.
PubMed
・ Chakkarapani E, Dingley J, Liu X, et al. Xenon enhances hypothermic neuroprotection in asphyxiated newborn pigs. Ann Neurol 2010 ; 68 : 330-341.
PubMed
・ Cilio MR, Ferriero DM. Synergistic neuroprotective therapies with hypothermia. Semin Fetal Neonatal Med 2010 ; 15 : 293-298.
PubMed
・ Iwata O, Iwata S, Robertson NJ, et al. Depth of delayed cooling alters neuroprotection pattern after hypoxia-ischemia. Ann Neurol 2005 ; 58 (1) : 75-87.
PubMed
P.123 掲載の参考文献
・ Gladstone DJ, Black SE, Hakim AM. Toward wisdom from failure : lessons from neuroprotective stroke trials and new therapeutic directions. Stroke 2002 ; 33 : 2123-2136.
PubMed
・ Iwata O, Iwata S. Filling the evidence gap : How can we improve the outcome of neonatal encephalopathy in the next 10 years? Brain Dev 2011 ; 33 : 221-228.
PubMed
・ Macleod MR, Fisher M, O'collins V, et al. Good laboratory practice : preventing introduction of bias at the bench. Stroke 2009 ; 40 : e50-e52.
 
P.125 掲載の参考文献
・ Azzopardi DV, Strohm B, Edwards AD, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med 2009 ; 361 (14) : 1349-1358.
PubMed
・ Shankaran S, Laptook AR, Ehrenkranz RA, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 2005 ; 353 (15) : 1574-1584.
PubMed
・ Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy : multicentre randomised trial. Lancet 2005 ; 365 (9460) : 663-670.
PubMed
・ Eicher DJ, Wagner CL, Katikaneni LP, et al. Moderate hypothermia in neonatal encephalopathy : efficacy outcomes. Pediatr Neurol 2005 ; 32 : 11-17.
PubMed
・ Lin ZU, Yu HM, Lin J, et al. Mild hypothermia via selective head cooling as neuroprotective therapy in term neonates with perinatal asphyxia : an experience from a single neonatal intensive care unit. J Perinatol 2006 ; 26 : 180-184.
 

付録

P.131 掲載の参考文献
・ Graham EM, Ruis KA, Hartman AL, et al. A systematic review of the role of intrapartum hypoxia-ischemia in the causation of neonatal encephalopathy. Am J Obstet Gynecol 2008 ; 199 (6) : 587-595.
PubMed
・ Azzopardi DV, Strohm B, Edwards AD, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med 2009 ; 361 (14) : 1349-1358.
PubMed
・ Eicher DJ, Wagner CL, Katikaneni LP, et al. Moderate hypothermia in neonatal encephalopathy : efficacy outcomes. Pediatr Neurol 2005 ; 32 (1) : 11-17.
PubMed
・ Shankaran S, Laptook AR, Ehrenkranz RA, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 2005 ; 353 (15) : 1574-1584.
PubMed
・ Simbruner G, Mittal RA, Rohlmann F, et al. Systemic hypothermia after neonatal encephalopathy : outcomes of neo.nEURO.network RCT. Pediatrics 2010 ; 126 (4) : e771-e778.
PubMed
・ Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy : multicentre randomised trial. Lancet 2005 ; 365 (9460) : 663-670.
PubMed
・ Lin ZL, Yu HM, Lin J, et al. Mild hypothermia via selective head cooling as neuroprotective therapy in term neonates with perinatal asphyxia : an experience from a single neonatal intensive care unit. J Perinatol 2006 ; 26 (3) : 180-184.
PubMed
・ Zhou WH, Cheng GQ, Shao XM, et al. Selective head cooling with mild systemic hypothermia after neonatal hypoxic-ischemic encephalopathy : a multicenter randomized controlled trial in China. J Pediatr 2010 ; 157 (3) : 367-372, 72 e1-72 e3.
 
・ Edwards AD, Brocklehurst P, Gunn AJ, et al. Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy : synthesis and meta-analysis of trial data. BMJ 2010 ; 340 : c363.
PubMed
・ Perlman JM, Wyllie J, Kattwinkel J, et al. Part 11 : neonatal resuscitation : 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation 2010 ; 122 (16 Suppl 2) : S516-S538.
 
・ Holmes G, Rowe J, Hafford J, et al. Prognostic value of the electroencephalogram in neonatal asphyxia. Electroencephalogr Clin Neurophysiol 1982 ; 53 (1) : 60-72.
PubMed
・ Sarnat HB, Sarnat MS. Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study. Arch Neurol 1976 ; 33 (10) : 696-705.
PubMed
・ al Naqeeb N, Edwards AD, Cowan FM, et al. Assessment of neonatal encephalopathy by amplitude-integrated electroencephalography. Pediatrics 1999 ; 103 (6 Pt 1) : 1263-1271.
 
・ Shalak LF, Laptook AR, Velaphi SC, et al. Amplitude-integrated electroencephalography coupled with an early neurologic examination enhances prediction of term infants at risk for persistent encephalopathy. Pediatrics 2003 ; 111 (2) : 351-357.
PubMed
・ Iwata S, Iwata O, Olson L, et al. Therapeutic hypothermia can be induced and maintained using either commercial water bottles or a "phase changing material" mattress in a newborn piglet model. Arch Dis Child 2009 ; 94 (5) : 387-391.
PubMed
・ Robertson NJ, Nakakeeto M, Hagmann C, et al. Therapeutic hypothermia for birth asphyxia in low-resource settings : a pilot randomised controlled trial. Lancet 2008 ; 372 (9641) : 801-803.
PubMed
・ Horn A, Thompson C, Woods D, et al. Induced hypothermia for infants with hypoxic-ischemic encephalopathy using a servo-controlled fan : an exploratory pilot study. Pediatrics 2009 ; 123 (6) : e1090-e1098.
 
・ Shellhaas RA, Soaita AI, Clancy RR. Sensitivity of amplitude-integrated electroencephalography for neonatal seizure detection. Pediatrics 2007 ; 120 (4) : 770-777.
PubMed
・ Thoresen M, Hellstrom-Westas L, Liu X, et al. Effect of hypothermia on amplitude-integrated electroencephalogram in infants with asphyxia. Pediatrics 2010 ; 126 (1) : e131-e139.
PubMed
・ Volpe JJ. Neonatal seizures : current concepts and revised classification. Pediatrics 1989 ; 84 (3) : 422-428.
PubMed
・ Scher MS, Aso K, Beggarly ME, et al. Electrographic seizures in preterm and full-term neonates : clinical correlates, associated brain lesions, and risk for neurologic sequelae. Pediatrics 1993 ; 91 (1) : 128-134.
PubMed
・ Hall RT, Hall FK, Daily DK. High-dose phenobarbital therapy in term newborn infants with severe perinatal asphyxia : a randomized, prospective study with three-year follow-up. J Pediatr 1998 ; 132 (2) : 345-348.
PubMed
・ Evans DJ, Levene MI, Tsakmakis M. Anticonvulsants for preventing mortality and morbidity in full term newborns with perinatal asphyxia. Cochrane Database Syst Rev 2007 (3) : CD001240.
PubMed

書評

最近チェックした商品履歴

Loading...