生体電気・物理刺激による　骨・軟部組織修復法

出版社： 金芳堂
著者：
発行日： 2013-02-28
分野： 臨床医学：外科  >  整形外科学
ISBN： 9784765315616
電子書籍版： 2013-03-08 （第1版第1刷）
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日本が世界に誇る，生体電気・物理刺激による骨・軟部組織修復研究の歴史および最新の基礎研究・応用法を集成した記念碑的成果.整形外科医・歯科医・医療工学研究者必携． 本書は，現在多彩な臨床応用がなされている，生体電気・物理刺激法の出発点となった，1953 年の故保田岩夫による世界初の「骨の圧電気現象と電気的仮骨」の報告から60 周年という節目を迎えたことを記念して企画された．

目次

  • 生体電気・物理刺激による　骨・軟部組織修復法

    ―目次―

    生体電気・物理刺激の歴史と展望
    1　生体電気刺激の回顧と展望
    2　日本生体電気・物理刺激研究会について
    3　生体電気刺激の現状と展望
    4　低出力超音波パルスによる物理学的刺激の歴史と展望

    基礎I　生体電気・物理刺激の物理現象
    1　生体電気刺激の物理現象
    2　生体磁場刺激の物理現象
    3　生体力学刺激の物理現象
    4　生体超音波刺激の物理現象

    基礎II　生体電気・物理刺激の細胞応答
    1　生体交流電気刺激による細胞応答
    2　磁場刺激による細胞応答
    3　生体液流刺激による細胞応答
    4　力学刺激に対する細胞応答：骨形成過程を中心に
    5　骨における生体力学刺激による細胞応答
    6　生体温熱刺激による細胞応答
    7　低出力超音波刺激の細胞による受容と伝達
    8　低出力超音波刺激による細胞応答
    9　イリザロフ法における細胞応答

    基礎III　生体電気・物理刺激の基礎研究
    1　生体直流電気刺激による骨形成と細胞応答
    2　生体直流刺激による腱・靱帯の修復促進
    3　電気刺激による神経修復促進
    4　交流電気刺激による骨形成促進
    5　パルス電磁場刺激による骨形成促進
    6　骨肉腫細胞に対するパルス電磁場刺激効果
    7　低出力超音波パルス刺激による内軟骨性骨化の促進
    8　低出力超音波刺激による靱帯修復促進
    9　温熱刺激による変形性関節症の進行抑制効果

    臨床　生体電気・物理刺激による骨・軟部組織形成促進
    1　生体電気・物理刺激療法のメタアナリシス
    2　上腕骨近位部骨折に対する創外固定・交流電気刺激法
    3　橈骨遠位端関節内骨折に対する交流電気刺激法
    　　　―交流電気刺激装置付き創外固定器と
    　　　　ロッキングプレートによる治療成績の比較―
    4　パルス電磁場刺激法によるION の予防効果
    5　骨折に対するパルス電磁場刺激法EBI Bone Healing System
    　　　の使用歴
    6　骨折に対する低出力超音波刺激法
    7　ペルテス病に対する近赤外線照射法
    8　骨折に対する衝撃波刺激法
    9　整形外科領域における体外衝撃波療法

この書籍の参考文献

参考文献のリンクは、リンク先の都合等により正しく表示されない場合がありますので、あらかじめご了承下さい。

本参考文献は電子書籍掲載内容を元にしております。

生体電気・物理刺激の歴史と展望

P.12 掲載の参考文献
1) 保田岩夫, 永山寿, 加藤常行, 他 : 骨折治療に関する基礎的諸問題. 京都医学会雑誌 4 : 395-406, 1953.
 
2) Fukada E, Yasuda I : On the piezoelectric effect of bone. J Phys Soc Jpn 12 : 1158-1162, 1957.
 
3) Fukada E, Yasuda I : Piezoelectric effects in collagen. Jpn J Appl Phys 3 : 117-121, 1964.
 
4) Fukada E : History and recent progress in piezoelectric polymers. IEEE Trans Ultra Ferro Freq Cont 47 : 1277-1290, 2000.
 
5) Namiki K, Hayakawa R, Wada Y : Molecular theory of piezoelectricity of α-helical polypeptide. J Polym Sci B18 : 993-1004, 1980.
 
6) Inoue S, Ohashi T, Fukada E, et al : Electric stimulation of osteogenesis in the rat, Electrical Properties of Bone and Cartilage (Brighton CT, Black J, Pollack SR Ed.), pp199-213, Grune & Stratton, 1979.
 
7) Kobayashi K, Nakamura S, Yamashita K : Enhanced osteobonding by negative surface charges of electrically polarized hydroxyapatite. J Biomed Mater Res 57 : 477-484, 2001.
 
8) Ikada Y, Shikinami Y, et al : Enhancement of bone formation by drawn poly (L-lactide). J Biomed Mater Res 30 : 553-558, 1996.
PubMed
9) Shimono T, Matsunaga S, et al : The effects of piezoelectric poly-L-lactic acid films in promoting ossification in vivo. In Vivo 10 : 471-476, 1996.
PubMed
10) Bassett CAL, Pawlak R, Pilla AA : Acceleration of fracture repair by electromagnetic fields. A surgically noninvasive method, Ann New York Acad Sci 238 : 242-262, 1974.
 
11) Brighton CT, Pollack SR : Treatment of nonunion of the tibia with a capacitively coupled electric field. J Trauma 24 : 153-155, 1984.
 
12) Duarte LR : The stimulation of bone growth by ultrasound. Arch Orthop Trauma Surg 101 : 153-159, 1983.
PubMed
13) Starkebaum W, Pollack SR, Korostoff E : Microelectrode studies of stress-generated potentials in four-point bending of bone. J Biomed Mater Res 13 : 729-751, 1979.
 
14) Krstic RV : Die Gewebe des Menschen und der Saugetiere. pp225, Springer-Verlag, 1978.
 
15) Maeda H, Fukada E : Effect of water on piezoelectric, dielectric and elastic properties of bone. Biopolymers 21 : 2055-2068, 1982.
PubMed
16) Ahn AC, Grodzinsky AJ : Relevance of collagen piezoelectricity to Wolff's Law" : A critical review. Med Eng Phys 31 : 733-741, 2009.
 
17) Date M, Kaneko I, Fukada E : Pulse Magnetic Stimulator for Biological Systems. Sci Papers IPCR 80 : 11-16, 1986.
 
18) Takahashi K, Kaneko I, Date M, et al : Effect of pulsing electromagnetic fields on DNA synthesis in mammalian cells in culture. Experientia 42 : 185-186, 1986.
PubMed
19) Matsunaga S, Sakou T, et al : Histochemical investigation of intramedullary callus by pulsed electromagnetic fields (PEMFs), Electromagnetics in Biology and Medicine. San Francisco Press, 1991.
 
20) 正岡利紀 : 骨牙細胞様細胞株 (MC3T3-E1) に対する変動電磁場刺激の及ぼす影響. 東医大誌 53 : 336-345, 1995.
 
21) 曽根真 : 変動電磁場刺激が骨牙細胞様細胞株 (MC3T3-E1) の細胞外基質に及ぼす影響. 東医大誌 55 : 500-509, 1997.
 
22) Pienkowski D, Pollack SR, et al : Comparison of asymmetrical and symmetrical pulse waveforms in electromagnetic stimulation. J Ortho Res 10 : 247-255, 1992.
 
23) Liboff AR, Smith SD, McLeod BR : Experimental evidence for ion cyclotron resonance mediation of membrane transport. J Bioelectricity 6 : 1-24, 1987.
 
24) 白石俊彦 : 振動数による細胞増殖. 産生基質量の変化の超音波治療への応用. 超音波TECHNO 1-2 : 89-93, 2008.
 
25) Lang SB : Pyroelectric effect in bone and tendon. Nature 212 : 704-705, 1966.
 
26) Lang SB, Tofail SAM, Gandhi AA, et al : Pyroelectric, piezoelectric and photoeffects in hydroxyapatite thin films on silicon. Appl Phys Lett 98 : 123-703, 2011.
 
27) Liu Y, Zhang Y, Chow M, et al : Biological ferroelectricity uncovered in aortic walls by piezoresponse force microscopy. Phys Rev Lett 108 : 078103, 2012.
PubMed
P.20 掲載の参考文献
1) 保田岩夫 : 骨折治療に関する基礎的諸問題. 京都医会誌 4 : 395-406, 1953.
 
2) 保田岩夫 : 生骨の圧電気現象に就て. 京都府立医大誌 53 : 325-326, 1953.
 
3) Yasuda I, Noguchi K, Sata T : Dynamic callus and electric callus. J Bone Joint Surg 37-A : 1292-1293, 1955.
 
4) Maatz R : Reaktion des Knochens auf Federdruck. Arch Orthop Unfallchir 44 : 529, 1951.
PubMed
5) 保田岩夫, 野口和彦, 飯田瞳 : 電気的仮骨の応用. 日整会誌 29 : 351, 1955.
Medical*Online
6) Fukada E, Yasuda I : On the piezoelectric effect of bone. J Phys Soc Jpn 12 : 1158-1162, 1957.
 
7) Bassett, CAL, Becker RO : Generation of electric potentials by bone in response to mechanical stress. Science 137 : 1063-1064, 1962.
 
8) Shamos MH, Lavine LS, Shamos MI : Piezoeloectric effect in bone. Nature 197 : 81, 1963.
PubMed
9) Fridenberg ZB, Brighton CT : Bioelectric potentials in bone. J Bone Joint Surg 48-A : 915, 1966.
 
10) Friedenberg ZB, Harlow MC, Brighton CT : Healing of non-union of the medial malleolus by means of direct current ; A case report. J Trauma 11 : 883-885, 1971.
 
11) Yasuda I : The Classic ; Fundamental aspects of fracture treatment. Clin Orthop, 124 : 5-8, 1977.
 
12) Brighton CT, Pollack SR, Windsor RE : Acceleration of fracture healing in the rabbit fibula by a capacitively coupled electric field. Transaction of the First Annual Meeting of the Bioelectrical Repair and Growth Society 36, 1981.
 
13) Brighton CT, Pollack SR : Treatment of recalcitrant non-union with a capacitively coupled electric field ; a preliminary report. J Bone Joint Surg 67-A : 577-585, 1985.
 
13) Duarte LR : The use of ultrasound to stimulate non-unions healing. Transactions of the Third Annual Meeting of the Bioelectrical Repair and Growth Society 31, 1983.
 
14) Brighton CT, Wang W, Seldes R, et al : Signal transduction in electrically stimulated bone cells. J Bone Joint Surg 83-A : 1514-1523, 2001.
 
15) Xu J, Wang W, Clark CC, et al : Signal transduction in electrically stimulated articular chondrocytes involves translocation of extracellular calcium through volatage-gated channels. Osteoarthritis Cartilage 17 : 397-405, Epub 2008.
 
16) 井上四郎, 大橋俊郎, 梶川究他 : CCEF法の骨癒合促進効果について. 生体電気刺激研究会誌 1 : 33-40, 1988.
 
17) Ohashi T, Inoue S, Sasaki H, et al : The electric current ratio of the bone in the rabbit thigh for capacitively coupled electric field. Transactions of the Fifth Annual Meeting of the Bioelectrical Repair and Growth Society 20, 1985.
 
P.39 掲載の参考文献
1) 保田岩夫 : 骨折治療に関する基礎的諸問題. 京都医学会雑誌 4 : 395-406, 1953.
 
2) Otter MW, McLeod KJ, Rubin CT, et al : Effects of electromagnetic fields in experimental fracture repair. Clin Orthop Relat Res 355 Suppl : 90-104, 1998.
 
3) Brighton CT, Wang W, Seldes R, et al : Signal transduction in electrically stimulated bone cells. J Bone Joint Surg Am 83-A : 1514-1523, 2001.
 
4) Rubin J, Rubin C, Jacobs CR, et al : Molecular pathways mediating mechanical signaling in bone. Gene 367 : 1-16, 2006.
PubMed
5) Aaron RK, Ciombor DM, Simon BJ, et al : Treatment of nonunions with electric and electromagnetic fields. Clin Orthop 419 : 21-29, 2004.
PubMed
6) Aaron RK, Boyan BD, Ciombor DM, et al : Stimulation of growth factor synthesis by electric and electromagnetic fields. Clin Orthop Relat Res 419 : 30-37, 2004.
PubMed
7) Chen JC, Carter DR : Important concepts of mechanical regulation of bone formation and growth. Current Opinion in Orthopaedics 16 : 338-345, 2005.
 
8) Ciombor DM, Aaron RK : The role of electrical stimulation in bone repair. Foot Ankle Clin 10 : 579-593, 2005.
PubMed
9) Haddad JB, Obolensky AG, Shinnick P, et al : The biologic effects and the therapeutic mechanism of action of electric and electromagnetic field stimulation on bone and cartilage : new findings and a review of earlier work. J Altern Complement Med 13 : 485-490, 2007.
 
10) Nelson FR, Brighton CT, Ryaby J, et al : Use of physical forces in bone healing. J Am Acad Orthop Surg 11 : 344-354, 2003.
PubMed
11) 松永俊二, 酒匂崇, 赤嶺卓哉 : 微弱直流電気刺激による髄内仮骨 刺激針と骨増生部位の関係について. 中部日本整形外科災害外科学会雑誌 29 : 504-506, 1986.
 
12) 松永俊二, 酒匂崇, 吉国長利, 他 : 微弱直流電気刺激による髄内仮骨 電気仮骨部アルカリフォスファターゼ活性値の経時的変化について. 生体電気刺激研究会誌 2 : 67-71, 1988.
 
13) 吉国長利, 酒匂崇 : 骨折に対する各種電気刺激療法 直流電気刺激法による偽関節症の治療経験. Orthopaedics 6 : 23-30, 1993.
 
14) 大橋俊郎, 谷知久, 大友克之, 他 : 骨形成に関する最近の進歩 電気刺激法について. 骨折 23 : 26-30, 2001.
Medical*Online
15) 河本浩栄, 金郁吉, 土田雄一, 他 : 交流電気刺激による延長仮骨形成促進. 整形・災害外科 45 : 315-319, 2002.
 
16) Kawamoto K, Kim WC, Tsuchida Y, et al : Effects of alternating current electrical stimulation on lengthening callus. J Pediatr Orthop B 14 : 299-302, 2005.
PubMed
17) 金郁吉, 吉田隆司, 山田尚武, 他 : 生体交流電気刺激の基礎と臨床. 日本生体電気・物理刺激研究会誌 25 : 1-11, 2011.
 
18) 湯川佳宣, 水田隆之 : 交流電気刺激法の難治性骨折への応用. MB Orthopaedics 6 : 45-60, 1993.
 
19) Itoh S, Ohta T, Sekino Y, et al : Treatment of distal radius fractures with a wrist-bridging external fixation -the value of alternating electric current stimulation-. J Hand Surg Eur 33 : 605-608, 2008.
PubMed
20) 亀山真, 斉藤憲太, 手塚正樹 : 橈骨遠位端骨折に対するnon-bridging創外固定法における骨電気刺激の有用性. 骨折 31 : 130-133, 2009.
Medical*Online
21) 代田雅彦, 小林雅文, 山田哲也, 他 : 上腕骨近位部骨折に対する骨交流電気刺激装置付き創外固定器の有用性について. 骨折 27 : 262-267, 2005.
Medical*Online
22) 宮城憲文, 佐藤啓二, 小林健二 : マウス骨肉腫細胞に対するパルス電磁場刺激の化学療法増強効果. 日本生体電気刺激研究会誌 11 : 23-28, 1997.
 
23) Goto T, Fujioka M, Ishida M, et al : Noninvasive up-regulation of angiopoietin-2 and fibroblast growth factor-2 in bone marrow by pulsed electromagnetic field therapy. Journal of Orthopaedic Science 15 : 661-665, 2010.
PubMed
24) 寺脇 稔, 岡田皖 : 骨折に対する各種電気刺激療法 理化学研究所考案のPEMFs法の臨床応用 Non-invasive法 : 理研・岡田法の臨床成績. Orthopaedics 6 : 79-86, 1993.
 
25) 松永俊二 : 骨折に対する各種電気刺激療法 理化学研究所考案のPEMFs法の基礎と臨床. Orthopaedics 6 : 69-77, 1993.
 
26) 元文芳和, 白井康正, 伊藤博元, 他 : Pulsing Electromagnetic Fieldsによる四肢難治性骨折の治療成績. 日本生体電気刺激研究会誌 11 : 53-54, 1997.
 
27) 伊藤博元 : 遷延治癒骨折・偽関節症例に対する電磁場刺激 (PEMFs) 療法. 運動療法と物理療法 10 : 102-106, 1999.
 
28) 井上四郎, 大東美生, 大橋俊郎, 他 : CCEF法による骨疾患の治療経験. 生体電気刺激研究会誌 5 : 43-50, 1991.
 
29) 和田野安良, 福林徹, 矢吹武, 他 : CCEF法を用いた疲労骨折の治療経験. 生体電気刺激研究会誌 5 : 57-60, 1991.
 
30) 伏見昌樹, 湯川佳宣, 水田隆之, 他 : CCEF (オステオBS-2000) 法による難治性骨折の治療. 日本生体電気刺激研究会誌 12 : 33-36, 1998.
 
31) 大橋俊郎, 井上四郎 : capacitively coupled electric field (CCEF) 法. 運動療法と物理療法 10 : 107-118, 1999.
 
32) 大橋俊郎, 谷知久, 大友克之, 他 : 骨形成に関する最近の進歩 電気刺激法について. 骨折 23 : 26-30, 2001.
Medical*Online
33) Oshitani T, Zhao J, Kuboyama N, et al : Effect of low-level laser irradiation on CXCL13 gene expression in rheumatoid arthritis rat joints. Journal of Hard Tissue Biology 19 : 89-94, 2010.
 
34) Makihara E, Masumi S : Blood flow changes of a superficial temporal artery before and after low-level laser irradiation applied to the temporomandibular joint area. 日本補綴歯科学会雑誌 52 : 167-170, 2008.
 
35) 柴秀行 : デンタルインプラントの埋入に対する低出力レーザーの応用. 日本レーザー治療学会誌 5 : 96-100, 2006.
 
36) 青山剛大 : He-Neレーザー照射がチタンプレート上のラット培養骨髄由来細胞に及ぼすLLLT効果. 日本歯科保存学雑誌 54 : 413-423, 2011.
Medical*Online
37) Friedenberg ZB, Brighton CT, Michelson JD, et al : The effects of demineralized bone matrix and direct current on an "in vivo" culture of bone marrow cells. J Orthop Res 7 : 22-27, 1989.
 
38) Brighton CT : The semi-invasive method of treating nonunion with direct current. Orthop Clin North Am 15 : 33-45, 1984.
PubMed
38) Binderman I, Somjen D, Shimshoni Z, et al : Stimulation of skeletal-derived cell cultures by different electric field intensities is cellspecific. Biochim Biophys Acta 21 : 273-279, 1985.
 
40) Armstrong PF, Brighton CT, Star AM : Capacitively coupled electrical stimulation of bovine growth plate chondrocytes grown in pellet form. J Orthop Res 6 : 265-271, 1988.
PubMed
41) Aaron RK, Ciombor DM, Simon BJ : Treatment of nonunions with electric and electromagnetic fields. Clin Orthop Relat Res 419 : 21-29, 2004.
PubMed
42) Brosseau L, Robinson V, Wells G, et al : Low level laser therapy (Classes I, II and III) for treating rheumatoid arthritis. Cochrane Database Syst Rev 19 : 4, 2005.
 
43) Jang H, Lee H : Meta-analysis of pain relief effects by las er irradiation on joint areas. Photomed Laser Surg 30 : 405-417, 2012.
 
44) Liu X, Lyon R, Meier HT, et al : Effect of lower-level laser therapy on rabbit tibial fracture. Photomed Laser Surg 25 : 487-494, 2007.
PubMed
45) Jawad MM, Husein A, Alam MK, et al : Overview of non-invasive factors (low level laser and low intensity pulsed ultrasound) accelerating tooth movement during orthodontic treatment. Lasers Med Sci Sep 18 (Epub), 2012.
 
46) 湯川佳宣, 真野淳, 津田欣徳, 他 : 交流電気刺激による難治性骨折の治療. 整形・災害外科 25 : 385-404, 1982.
 
47) Hirashima T, Kim WC, Kawamoto K, et al : Evaluation of bone union of distal radius fracture by measuring impedance values. Orthopedics 32 : 31-33, 2009.
PubMed
48) Cunningham JL, Kenwright J, Kershaw CJ : Biomechanical measurement of fracture healing. J Med Eng Technol 14 : 92-101, 1990.
PubMed
49) Blokhuis TJ, den Boer FC, Bramer JA, et al : Evaluation of strength of healing fractures with dual energy Xray absorptiometry. Clin Orthop Relat Res 380 : 260-268, 2000.
PubMed
50) Watanabe Y, Takai S, Arai Y, et al : Prediction of mechanical properties of healing fractures using acoustic emission. J Orthop Res 19 : 548-553, 2001.
 
51) Matsuyama J, Ohnishi I, Sakai R, et al : A new method for evaluation of fracture healing by echo tracking. Ultrasound Med Biol 34 : 775-783, 2008.
PubMed
52) Harp JH, Aronson J, Hollis M : Noninvasive determination of bone stiffness for distraction osteogenesis by quantitative computed tomography scans. Clin Orthop Relat Res 301 : 42-48, 1994.
PubMed
53) Bail HJ, Kolbeck S, Krummrey G, et al : Ultrasound can predict regenerate stiffness in distraction osteogenesis. Clin Orthop Relat Res 404 : 362-367, 2002.
PubMed
54) Yoshida T, Kim WC, Kawamoto K, et al : Measurement of bone electrical impedance in fracture healing. J Orthop Sci 14 : 320-329, 2009.
PubMed
55) Yoshida T, Kim WC, Oka Y, et al : Assessment of distraction callus in rabbits by monitoring of the electrical impedance of bone. Acta Orthop 81 : 628-633, 2010.
PubMed
P.47 掲載の参考文献
1) 神宮司誠也 : 低出力超音波パルス-骨折に対する積極的保存療法-. 骨・関節・靭帯 13 : 443-447, 2000.
 
2) Duarte LR : The stimulation of bone growth by ultrasound. Arch Orthop Trauma Surg 101 : 153-159, 1983.
PubMed
3) Xavier CAM, Duarte LR : Stimulation of bone callus by ultrasound (Portuguese). Rev Brasil Ortop 18 : 73-80, 1983.
 
4) Heckman JD, Ryaby JP, McCabe J, et al : Acceleration of tibial-healing by non-invasive, low-intensity pulsed ultrasound. J Bone Joint Surg 76-A : 26-34, 1994.
PubMed
5) Kristiansen TK, Ryaby JP, McCabe J, et al : Accelerated healing of distal radius fractures with the use of specific, low-intensity ultrasound. J Bone Joint Surg 79-A : 961-973, 1997.
 
6) 神宮司誠也, 岩本幸英, 東由明, 他 : ラット大腿骨骨折治癒への低出力超音波パルス照射の効果. 骨折 21 : 655-658, 1999.
Medical*Online
7) 水野耕作, 山野慶樹, 糸満盛憲, 他 : 超音波骨折治療器の遷延癒合・偽関節に対する多施設臨床試験. 整・災外 46 : 757-765, 2003.
 
8) Jingushi S, Mizuno K, Matsushita T, et al : Low-intensity pulsed ultrasound treatment for postoperative delayed union or nonunion of long bone fractures. J Orthop Sci 12 : 35-41, 2007.
PubMed
9) Wang SJ, Lewallen DG, Bolander ME, et al : Low intensity ultrasound treatment increases strength in a rat femoral fracture model. J Orthop Res 12 : 40-47, 1994.
 
10) 岩渕禎弘, 高林淳一 : 治療ヘッドについて. In : 神宮司誠也, 松下隆, ed. 骨折に対する低出力超音波パルス治療の基礎と臨床. メディカルレビュー社, pp29-34, 2008.
 
11) Yang K-H, Parvizi J, Wang S-J, et al : Exposure to low-intensity ultrasound increases aggrecan gene expression in a rat femur fracture model. J Orthop Res 12 : 40-47, 1996.
 
12) Jingushi S, Joyce ME, Bolander ME : Genetic expression of extracellular matrix proteins correlates with histologic changes during fracture repair. J Bone Miner Res 7 : 1045-1055, 1992.
PubMed
13) 神宮司誠也 : これまでの基礎研究の概略 (神宮司誠也, 松下隆 : 骨折に対する低出力超音波パルス治療の基礎と臨床). メディカルレビュー社, pp43-50, 2008.
 
14) Iwaki A, Jingushi S, Oda Y, et al : Localization and quantification of proliferating cells during rat fracture repair-Detection of proliferating cell nuclear antigen by immunohistochemistry. J Bone Miner Res 12 : 96-102, 1997.
PubMed
15) Azuma Y, Ito M, Harada Y, et al : Low-intensity pulsed ultrasound accelerates rat femoral fracture healing by acting on the various cellular reactions in the fracture callus. J Bone Mineral Res 16 : 671-680, 2001.
PubMed

基礎I 生体電気・物理刺激の物理現象

P.59 掲載の参考文献
1) Fukada E, Yasuda I : On the piezoelectric effect on bone. J Phys Soc Japan 12 : 1158-1162, 1957.
 
2) Ahn AC, Grodzinsky AJ : Relevance of collagen piezoelectricity to "Wolff's Law" : A critical review. Med Eng Phys 31 : 733-741, 2009.
 
3) Nakamura S, Takeda H, Yamashita K : Proton transport polarization and depolarization of hydroxyapatite ceramics. J Appl Phys 89 : 5386-5392, 2001.
 
4) Zapanta-LeGeros R : Effect of carbonate on the lattice parameters of apatite. Nature 206 : 403-404, 1965.
PubMed
5) Nakamura M, Hiratai R, Yamashita K : Bone mineral as an electrical energy reservoir. J Biomed Mater Res A 100A : 1368-1374, 2012.
 
6) Fukada E, Yasuda I : On the piezoelectric effect on bone. J Phys Soc Japan 12 : 1158-1162, 1957.
 
7) Brighton CT : The treatment of non-unions with electricity. J Bone Joint Surg Am 63 : 847-851, 1981.
PubMed
8) Mascarenhas S : The electret effect in bone and biopolymers and the bound-water problem. Ann NY Acad Sci 238 : 36-52, 1974.
 
9) Yamashita K, Oikawa N, Umegaki T : Acceleration and deceleration of bone-like crystal growth on ceramic hydroxyapatite by electric poling. Chem Mater 8 : 2697-2700, 1996.
 
10) Ueshima M, Nakamura S, Yamashita K : Huge, millicoulomb charge storage in ceramic hydroxyapatite by bimodal electric polarization. Adv Mater14 : 591-593, 2002.
 
11) Nakamura M, Nakamura S, Sekijima Y, et al : Role of blood coagulation components as intermediators of high osteoconductivity of electrically polarized hydroxyapatite. J Biomed Mater Res A 79 : 627-634, 2006.
PubMed
12) Nakamura M, Nagai A, Hentunen T, et al : Surface electric fields increase osteoblast adhesion through improved wettability on hydroxyapatite electret. ACS Appl Mater Interfaces 1 : 2181-2189, 2009.
PubMed
13) Kobayashi T, Nakamura S, Yamashita K : Enhanced osteobonding by negative surface charges of electrically polarized hydroxyapatite. J Biomed Mater Res 57 : 477-484, 2001.
PubMed
14) Itoh S, Nakamura S, Kobayashi T, et al : Effect of electrical polarization of hydroxyapatite ceramics on new bone formation. Calcified Tissue Int 78 : 133-142, 2006.
 
P.65 掲載の参考文献
1) 保田岩夫, 永山壽, 加藤常行, 他 : 骨折治療に関する基礎的諸問題. 京都医師会誌 : 395-406, 1953.
 
2) Yasuda I : Fundamental aspects of fracture treatment. Cli Orthp 124 : 5-8, 1977.
 
3) Fukada E, Yasuda I : On the piezoelectric effect of bone. J Phys Soc Japan 12 : 1158-1162, 1957.
 
4) Bassett CAL, Becker RO : Generation of electric potentials by bone in response to mechanical stress. Science 137 : 1063-1064, 1962.
 
5) Bassett CAL, Pawluck RJ, Becker RO : Effects of electric currents on bone in vivo. Nature 204 : 652-654, 1964.
 
6) Bassett CAL, Pawluck RJ, Pilla AA : Augmentation of bone repair by inductively coupled electromagnetic fields. Science 184 : 575-577, 1974.
 
7) Ueno S, Harada K : Experimental difficulties in observing the effects of magnetic fields on biological and chemical processes. IEEE Transactions on Magnetics MAG 22 : 2752-2757, 1987.
 
8) Ueno S (ed) : Biomagnetic Stimulation. pp1-136, Plenum Press, 1994.
 
9) Ueno S (ed) : Biological effects of magnetic and electromagnetic fields. pp1-243, Plenum Press, 1996.
 
10) Ueno S, Iwasaka M : Properties of diamagnetic fluid in high gradient magnetic fields. Journal of Applied Physics 75 : 7177-7179, 1994.
 
11) Lovsund P, Oberg PA, Nilsson SEG, et al : Magnetophophenes : A quantitative analysis of thresholds. Medical and Biological Engineering and Computing 28 : 326-334, 1980.
 
12) Barker AT, Jalinous R, Freeston IL : Noninvasive magnetic stimulation of human motor cortex. The Lancet i : 1325-1326, 1985.
 
13) Ueno S, Tashiro T, Haada K : Localized stimulation of neural tissues in the brain by means of paired configuration of time-varying magnetic fields. Journal of Applied Physics 64 : 5862-5864, 1988.
 
14) Ueno S, Matsuda T, Fujiki M : Functional mapping of the human motor cortex obtained by focal and vectorial magnetic stimulation of the brain. IEEE Transactions on Magnetics 26 : 1539-1544, 1990.
 
15) Torbet J, Fryssinet, Hudry-Clergeon G : Oriented fibrin gels formed by polymerization in strong magnetic fields. Nature 289 : 91-93, 1981.
PubMed
16) Eguchi Y, Ogiue-Ikeda M, Ueno S : Control of orientation of rat Schwann cells using an 8-T static magnetic field. Neuroscience Letters 351 : 130-132, 2003.
PubMed
17) Kotani H, Kawaguchi H, Shimoaka T, et al : Strong static magnetic field stimulates bone formation to a definite orientation in vitro and in vivo. Journal of Bone and Mineral Research 17 : 1814-1821, 2002.
PubMed
18) Shulten K, Staerk H, Weller A, et al : Magnetic field dependence of the geminate recombination of radical ion pairs in polar solvents. Z Phys Chem N F 101 : 371-390, 1976.
 
19) Tanimoto Y, Hayashi H, Nagakura S, et al : The external magnetic field effect on the singlet sensitized photolysis of dibenzoyl peroxide. Chem Phys Lett 41 : 267-269, 1976.
 
20) Haberditzl W : Enzyme activity in high magnetic fields. Nature 213 : 72-73, 1967.
 
21) Ueno S, Iriguchi N : Impedance magnetic resonance imaging : a method for imaging of impedance distributions based on magnetic resonance imaging. Journal of Applied Physics 83 : 6450-6452, 1998.
 
22) Sekino M, Yamaguchi K, Iriguchi N, et al : Conductivity tensor imaging of the brain using diffusion-weighted magnetic resonance imaging. Journal of Applied Physics 93 : 6730-6732, 2003.
 
P.74 掲載の参考文献
1) Glimcher MJ : On the form of bone ; from molecules to organs, Wolff's law revisited. In : Veis A (ed) : The Chemistry and Biology of Mineralized Connective Tissues. pp618-673, Elsevier, 1981.
 
2) 保田岩夫, 永山寿, 加藤常行, 他 : 骨折治療に関する基礎的諸問題. 京都医学会誌 4 : 395-406, 1953.
 
3) 平沢泰介, 岡田皖 : 骨折治療における電気刺激その最近の進歩と話題. 総合リハビリ 17, 1 : 5-11, 1989.
 
4) 野口和彦 : 力学的仮骨並びに電気的仮骨の研究. 日整会誌 31 : 619-641, 1957.
Medical*Online
5) 深田栄一 : 骨の電気力学的刺激の研究. 日本生体電気・物理刺激研究会誌 24 : 1-10, 2010.
 
6) Wang Y, Mcnamara LM, Schaffler MB, et al : A model for the role of integrins in flow induced mechanotransduction in osteocytes. PNAS 104 : 15941-15946, 2007.
 
7) Wong AT, Czernuszka JT : Transformation behavior of calcium phosphate 1 ; Theory and modeling, Colloid and Surface A. Physicochemical and Engineering Aspects 78 : 245-253, 1984.
 
8) 横堀武夫 : 材料強度学. 第2版, pp250-256, 岩波全書 (岩波書店), 1974.
 
9) Shewmon PG : Diffusion in Solid. McGraw-Hill, 1963 : 固体内の拡散 (笛木和雄, 北沢宏一訳). pp136-140, コロナ社, 1976.
 
10) Fung YC : Foundation of Solid Mechanics. Prentice Hall, 1965 : 固体の力学 (大橋義史, 村上澄男, 神谷紀生訳). pp370-373, 培風館, 1970.
 
11) Yokobori AT Jr, Nemoto T, Satoh K, et al : Numerical analysis on hydrogen diffusion and concentration in solid with emission around the crack tip. Engineering Fracture Mechanics 55 : 47-60, 1996.
 
12) Yokobori AT Jr, Ohmi T, Murakawa T, et al : Strength, Fracture and Complexity. An Int J 7 : 215-233, 2011.
 
13) Oriani RA : Hydrogen in metals, In fundamental aspects of stress corrosion cracking, 32. In : Staehle RW, Forty AJ, Rooyen DV (eds) : NACE, 1969.
 
14) Stanley G, Schultz : "Basic Principles of membrane transport" : 生体膜輸送の基礎 (鈴木泰三, 星猛, 鈴木裕一訳). 東京化学同人, 1982.
 
15) Yokobori AT Jr, Miyasaka Y, Sakurai M : Theory of osteogenesis behavior based on calcium diffusion theory. Bio-Medical Materials and Engineering 5 : 209-217, 1995.
PubMed
16) Oriani RA : J of Physics and Chemistry of Solid 30 : 339-351, 1969.
 
17) 千賀進也, 杉山肇, 他 : 成長ひずみ法を用いた大腿骨大転子部骨折のCHSおよびNail固定における形状解析. 日本臨床バイオメカニクス学会誌 : 21-28, 2007.
 
18) Reilly DT, Burstein AH : The elastic and ultimate properties of compact bone tissue. J Biomech 8 : 393-405, 1975.
PubMed
19) 青山和裕, 末吉泰信, 坂本二郎, 他 : 骨形成に及ぼす力学的刺激の影響 (組織学的検討). 日本臨床バイオメカニクス学会誌 15 : 79-84, 1994.
Medical*Online
20) Ohyama M, Miyasaka Y, Sakurai M, et al : The mechanical behavior and morphological structure of callus in experimental callotasis. Bio-medical materilas and Engineering 4 : 273-281, 1004.
 
21) 横堀壽光, 西本達矢, 大見敏仁, 他 : 応力誘起物質拡散による骨形成過程に及ぼす力学的効果 (第2報). 日本生体電気・物理刺激研究会誌 24 : 23-30, 2010.
 
22) 横堀壽光, 西本達矢, 大見敏仁 : 骨形成における応力誘起物質拡散機構の役割. 日本生体電気・物理刺激研究会誌 25 : 13-19, 2011.
 
23) 横堀壽光, 西本達矢, 大見敏仁, 他 : 力学的および電気的刺激による骨形成イオンの骨内拡散挙動連成解析. 日本生体電気・物理刺激研究会誌 26 : 9-19, 2012.
 
P.83 掲載の参考文献
1) Heckman JD, Rvaby JP, McCabe J, et al : Acceleration of tibial fracture-healing by noninvasive, low-intensity pulsed ultrasound. J Bone Joint Surg Am 76-A : 26-34, 1994.
 
2) Kristiansen TK, Ryaby JP, McCabe J, et al : Accelerated healing of distal radial fractures with the use of specific, low-intensity ultrasound. A multicenter, prospective, randomized, doubleblind, placebo-controlled study. J Bone Joint Surg Am 79-A : 961-973, 1997.
PubMed
3) Hadjiargyrou M, MLeod K, Ryaby JP, et al : Enhancement of fracture healing by low intensity ultrasound. Clin Orthop Relat Res 355S : 216-229, 1998.
 
4) 社団法人日本超音波医学会 機器及び安全に関する委員会 Working Group報告 http://www.jsum.or.jp/committee/uesc/index.html
 
5) Pilla AA, Mont MA, Nasser PR, et al : Noninvasive low-intensity pulsed ultrasound accelerates bone healing in the rabbit. J Orthop Trauma 4 : 246-253, 1990.
 
6) Iwabuchi S, Ito M, Hata J, et al : In vitro evaluation of low-intensity pulsed ultrasound in herniated disc resorption. Biomaterials 26 : 7104-7114, 2005.
PubMed
7) Park SC, Oh SH, Seo TB, et al : Ultrasoundstimulated peripheral nerve regeneration within asymmetrically porous PLGA/Pluronic F127 nerve guide conduit. J Biomed Mater Res B Appl Biomater 94 : 359-366, 2010.
 
8) Signori LU, Costa ST, Neto AF, et al : Haematological effect of pulsed ultrasound in acute muscular inflammation in rats. Physiotherapy 97 : 163-169, 2010.
PubMed
9) Franco de OR, Pires Oliveira DA, Soares CP : Effect of low-intensity pulsed ultrasound on I929 fibroblasts. Arch Med Sci 7 : 224-229, 2011.
 
10) Jeremias Junior SL, Camanho GL, Bassit AC, et al : Low-intensity pulsed ultrasound accelerates healing in rat calcaneus tendon injuries. J Orthop Sports Phys Ther 41 : 526-531, 2011.
PubMed
11) Jiang T, Xu T, Gu F, et al : Osteogenic effect of low intensity pulsed ultrasound on rat adiposederived stem cells in vitro. J Huazhong Univ Sci Technolog Med Sci 32 : 75-81, 2012.
PubMed
12) Iwabuchi S, Ito M, Chikanishi T, et al : Role of the tumor necrosis factor-alpham cyclooxygenase-2, prostaglandin E2, and effect of low-intensity pulsed ultrasound in an in vitro herniated disc resorption. J Orthop Res 26 : 1274-1278, 2008.
 
13) Shiraishi R, Masaki C, Toshinaga A, et al : The effects of low-intensity pulsed ultrasound exposure on gingival cells. J Periodontol 82 : 1498-1503, 2011.
 
14) 神宮司誠也, 岩本幸英, 東由明, 他 : ラット大腿骨骨折治療への低出力超音波パルス照射の効果. 骨折 21 : 655-658, 1999.
 
15) 岩淵禎弘, 高林淳一 : 治療ヘッド設置について (神宮司誠也, 松下隆 : 骨折に対する低出力超音波パルス治療の基礎と臨床). pp29-34, メディカルビュー社, 2008.
 
16) Yang KH, Parvizi J, Wang SJ, et al : Exposure to low-intensity ultrasound increases aggrecan gene expression in a rat femur fracture model. J Orthop Res 14 : 802-809, 1996.
 
17) 新井通浩, 竹中信之, 芳野晃, 他 : 難治性骨折に対する低出力超音波パルス (LIPUS) の治療成績とターゲッティングの工夫. 骨折 27 : 21-26, 2005.
 
18) Naito K, Watari T, Muta T, et al : Low-intensity pulsed ultrasound (LIPUS) increases the articular cartilage typeII collagen in a rat osteoarthritis model. J Orthop Res 28 : 361-369, 2010.
 
19) Li X, Li J, Cheng K, et al : Effect of low-intensity pulsed ultrasound on MMP-13 and MAPKs signaling pathway in rabbit knee osteoarthritis. Cell Biochem Biophys 61 : 427-434, 2011.
 
20) Loyola-Sanchez A, Richardson J, Beattie KA, et al : Effect of low-intensity pulsed ultrasound on the cartilage repair in people with mild to moderate knee osteoarthritis : a double-blinded, randomized, placebo-controlled pilot study. Arch Phys Med Rehabil 93 : 35-42, 2012.
PubMed
21) Lim D, Ko CY, Seo DH, et al : Low-intensity ultrasound stimulation prevents osteoporotic bone loss in young adult ovariectomized mice. J Orthop Res 29 : 116-125, 2011.
PubMed
22) Ferreri SL, Talish R, Trandafir T, et al : Mitigation of bone loss with ultrasound induced dynamic mechanical signals in an OVX induced rat model of osteopenia. Bone 48 : 1095-1102, 2011.
 
23) Iwashina T, Mochida J, Miyazaki T, et al : Low-intensity pulsed ultrasound stimulates cell proliferation and proteoglycan production in rabbit intervertebral disc cells cultured in alginate. Biomaterials 27 : 354-361, 2006.
PubMed
24) Hiyama A, Mochida J, Iwashina T, et al : Synergistic effect of low-intensity pulsed ultrasound on growth factor stimulation of nucleus pulposus cells. J Orthop Res 25 : 1574-1581, 2007.
 
25) Omi H, Mochida J, Iwashina T, et al : Lowintensity pulsed ultrasound stimulation enhances TIMP-1 in nucleus pulposus cells and MCP-1 in macrophages in rat. J Orthop Res 26 : 865-871, 2008.
 
26) Kobayashi Y, Sakai D, Iwashina T, et al : Low-intensity pulsed ultrasound stimulates cell proliferation, proteoglycan synthesis and expression of growth factor-related genes in human nucleus pulposus cell line. Eur Cell Mater 17 : 15-22, 2009.
PubMed
27) 米田征司, 高木宏太, 伊藤範明, 他 : 低出力超音波パルス照射のインプラント体表面性状に対する効果. 岐阜歯科学会雑誌 34 : 64-71, 2007.
 
28) 安光秀人, 江原雄二, 神田省吾, 他 : 歯科治療における物理療法の有効性. 日本顎咬合学会誌 31 : 85-99, 2011.
Medical*Online
29) 吉野晃, 藤井秀明 : 低出力超音波パルス治療の臨床応用-メカニカルストレスを応用し, 骨の再生, 治癒促進を図る-. Dental Diamond 36 : 48-55, 2011.
 

基礎II 生体電気・物理刺激の細胞応答

P.88 掲載の参考文献
1) 保田岩夫, 永山壽, 加藤常行, 他 : 骨折治療に関する基礎的諸問題. 京都医学会雑誌 4 : 395-406, 1953.
 
2) Bassett CAL, Pawluk RJ, Pilla AA : Augmentation of bone repair by inductively coupled electromagnetic fields. Science 184 : 575-577, 1974.
 
3) Brighton CT, Wang W, Seldes R, et al : Signal transduction in electrically stimulated bone cells. J Bone Joint Surg Am 83-A : 1514-1523, 2001.
 
4) Aaron RK, Wang S, Ciombor DM : Upreglation of basal TGF β1 levels by EMF coincident with chondrogenesis- implications for skeletal repair and tissue engineering. J Orthop Res 20 : 233-240, 2002.
 
5) 保田岩夫, 野口和彦, 飯田瞳 : 電気的仮骨の応用. 日整会誌 29 : 351-353, 1955.
Medical*Online
6) Itoh S, Ohta T, Sekino Y, et al : Treatment of distal radius fractures with a wrist-bridging external fixation : the value of alternating electric current stimulation. J Hand Surg Eur 33 : 605-608, 2008.
PubMed
7) Kawamoto K, Kim WC, Tsuchida Y, et al : Effects of alternating current electrical stimulation on lengthening callus. J Pediatr Orthop B 14 : 299-302, 2005.
PubMed
8) Hirashima T, Kim WC, Kawamoto K, et al : Evaluating of bone union of distal radius fractures by measuring impedance values. Orthopedics 32 : 31-33, 2009.
PubMed
9) 湯川佳宣, 水田隆之 : 交流電気刺激法, 直達式. (生体電気刺激研究会編 : 電気刺激による骨・軟部組織修復の促進 その基礎と応用). pp63-91, 文光堂, 1993.
 
10) Rubin J, Rubin C, Jacobs CR : Molecular pathways mediating mechanical signaling in bone. Gene 367 : 1-16, 2006.
PubMed
11) Ahn AC, Grodzinsky AJ : Relevance of collagen piezoelectricity to "Wolff's Law" : a critical review. Med Eng Phys 31 : 733-741, 2009.
 
12) Supronowicz PR, Ajayan PM, Ullmann KR, et al : Novel current-conducting composite substrates for exposing osteoblasts to alternating current stimulation. J Biomed Mater Res 59 : 499-506, 2002.
PubMed
13) Wu CC, Li YS, Haga JH, et al : Roles of MAP kinases in the regulation of bone matrix Gene expressions in human osteoblasts by oscillatory fluid flow. J Cell Biochem 98 : 632-641, 2006.
 
14) You J, Reilly GC, Zhen X, et al : Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts. J Biol Chem 276 : 13365-13371, 2001.
PubMed
P.95 掲載の参考文献
1) Luben RA, Cain CD, Chen MC, et al : Effects of electromagnetic stimuli on bone and bone cells in vitro : inhibition of responses to parathyroid hormone by low-energy low-frequency fields. Proc Natl Acad Sci USA 79 : 4180-4184, 1982.
 
2) Marron MT, Goodman EM, Sharpe PT, et al : Low frequency electric and magnetic fields have different effects on the cell surface. FEBS Lett 230 : 13-16, 1988.
PubMed
3) Luben RA : Effects of low-energy electromagnetic fields (pulsed and DC) on membrane signal transduction processes in biological systems. Health Phys 61 : 15-28, 1991.
PubMed
4) Varani K, De Mattei M, Vincenzi F, et al : Characterization of adenosine receptors in bovine chondrocytes and fibroblast-like synoviocytes exposed to low frequency low energy pulsed electromagnetic fields. Osteoarthritis Cartilage 16 : 292-304, 2008.
PubMed
5) Ongaro A, Pellati A, Masieri FF, et al : Chondroprotective effects of pulsed electromagnetic fields on human cartilage explants. Bioelectromagnetics 32 : 543-551, 2011.
PubMed
6) Fitzsimmons RJ, Ryaby JT, Magee FP, et al : IGF-II receptor number is increased in TE-85 osteosarcoma cells by combined magnetic fields. J Bone Miner Res 10 : 812-819, 1995.
PubMed
7) Brighton CT, Wang W, Seldes R, et al : Signal transduction in electrically stimulated bone cells. J Bone Joint Surg Am 83-A : 1514-1523, 2001.
 
8) Patterson TE, Sakai Y, Grabiner MD, et al : Exposure of murine cells to pulsed electromagnetic fields rapidly activates the mTOR signaling pathway. Bioelectromagnetics 2 : 535-544, 2006.
PubMed
9) Selvamurugan N, Kwok S, Vasilov A, et al : Effects of BMP-2 and pulsed electromagnetic field (PEMF) on rat primary osteoblastic cell proliferation and gene expression. J Orthop Res 25 : 1213-1220, 2007.
PubMed
10) De Mattei M, Caruso A, Traina GC, et al : Correlation between pulsed electromagnetic fields exposure time and cell proliferation increase in human osteosarcoma cell lines and human normal osteoblast cells in vitro. Bioelectromagnetics 20 : 177-182, 1999.
PubMed
11) Diniz P, Shomura K, Soejima K, et al : Effects of pulsed electromagnetic field (PEMF) stimulation on bone tissue like formation are dependent on the maturation stages of the osteoblasts. Bioelectromagnetics 23 : 398-405, 2002.
 
12) Chang WH, Chen LT, Sun JS, et al : Effect of pulse-burst electromagnetic field stimulation on osteoblast cell activities. Bioelectromagnetics 25 : 457-465, 2004.
PubMed
13) Lohmann CH, Schwartz Z, Liu Y, et al : Pulsed electromagnetic fields affect phenotype and connexin 43 protein expression in MLO-Y4 osteocyte-like cells and ROS 17/2. 8 osteoblast-like cells. J Orthop Res 21 : 326-334, 2003.
 
14) Schwartz Z, Fisher M, Lohmann CH, et al : Osteoprotegerin (OPG) production by cells in the osteoblast lineage is regulated by pulsed electromagnetic fields in cultures grown on calcium phosphate substrates. Ann Biomed Eng 37 : 437-444, 2009.
PubMed
15) Lohmann CH, Schwartz Z, Liu Y, et al : Pulsed electromagnetic field stimulation of MG63 osteoblast-like cells affects differentiation and local factor production. J Orthop Res 18 : 637-646, 2000.
PubMed
16) Martino CF, Belchenko D, Ferguson V, et al : The effects of pulsed electromagnetic fields on the cellular activity of SaOS-2 cells. Bioelectromagnetics 29 : 125-132, 2008.
PubMed
17) Bodamyali T, Bhatt B, Hughes FJ, et al : Pulsed electromagnetic fields simultaneously induce osteogenesis and upregulate transcription of bone morphogenetic proteins 2 and 4 in rat osteoblasts in vitro. Biochem Biophys Res Commun 250 : 458-461, 1998.
PubMed
18) Owen TA, Aronow M, Shalhoub V, et al : Progressive development of the rat osteoblast phenotype in vitro : reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix. J Cell Physiol 143 : 420-430, 1990.
PubMed
19) Schwartz Z, Simon BJ, Duran MA, et al : Pulsed electromagnetic fields enhance BMP-2 dependent osteoblastic differentiation of human mesenchymal stem cells. J Orthop Res 26 : 1250-1255, 2008.
PubMed
20) Tsai MT, Li WJ, Tuan RS, et al : Modulation of osteogenesis in human mesenchymal stem cells by specific pulsed electromagnetic field stimulation. J Orthop Res 27 : 1169-1174, 2009.
PubMed
21) Pezzetti F, De Mattei M, Caruso A, et al : Effects of pulsed electromagnetic fields on human chondrocytes : an in vitro study. Calcif Tissue Int 65 : 396-401, 1999.
 
22) De Mattei M, Caruso A, Pezzetti F, et al : Effects of pulsed electromagnetic fields on human articular chondrocyte proliferation. Connect Tissue Res 42 : 269-279, 2001.
PubMed
23) De Mattei M, Pellati A, Pasello M, et al : Effects of physical stimulation with electromagnetic field and insulin growth factor-I treatment on proteoglycan synthesis of bovine articular cartilage. Osteoarthritis Cartilage 12 : 793-800, 2004.
PubMed
24) Massari L, Benazzo F, De Mattei M, et al : Effects of electrical physical stimuli on articular cartilage. J Bone Joint Surg Am 89 Suppl 3 : 152-161, 2007.
 
25) De Mattei M, Varani K, Masieri FF, et al : Adenosine analogs and electromagnetic fields inhibit prostaglandin E2 release in bovine synovial fibroblasts. Osteoarthritis Cartilage 17 : 252-262, 2009.
PubMed
26) Ongaro A, Varani K, Masieri FF, et al : Electromagnetic fields (EMFs) and adenosine receptors modulate prostaglandin E (2) and cytokine release in human osteoarthritic synovial fibroblasts. J Cell Physiol 227 : 2461-2469, 2012.
PubMed
27) Yen-Patton GP, Patton WF, Beer DM, et al : Endothelial cell response to pulsed electromagnetic fields : stimulation of growth rate and angiogenesis in vitro. J Cell Physiol 134 : 37-46, 1988.
PubMed
28) Tepper OM, Callaghan MJ, Chang EI, et al : Electromagnetic fields increase in vitro and in vivo angiogenesis through endothelial release of FGF-2. FASEB J 18 : 1231-1233, 2004.
PubMed
29) Callaghan MJ, Chang EI, Seiser N, et al : Pulsed electromagnetic fields accelerate normal and diabetic wound healing by increasing endogenous FGF-2 release. Plast Reconstr Surg 121 : 130-141, 2008.
PubMed
30) Goto T, Fujioka M, Ishida M, et al : Noninvasive up-regulation of angiopoietin-2 and fibroblast growth factor-2 in bone marrow by pulsed electromagnetic field therapy. J Orthop Sci 15 : 661-665, 2010.
PubMed
P.102 掲載の参考文献
1) Flaherty JT, Pierce JE, Ferrans VJ, et al : Endothelial nuclear patterns in the canine arterial tree with particular reference to hemodynamic events. Circulation Research 9 : 23-33, 1972.
 
2) Cooke JP, Rossitch E Jr, Andon NA, et al : Flow activates an endothelial potassium channel to release an endogenous nitrovasodilator. J Clin Invest 88 : 1663-1671, 1991.
PubMed
3) Anderson SA, Cohn SH, et al : Bone demineralization during space flight. Physiologis 28 : 212-217, 1985.
 
4) Arnaud SB, Sherrard DJ, Maloney N, et al : Effects of 1-week head-down tilt bed rest on bone formation and the calcium endocrine system. Aviat Space Environ Med 63 : 14-20, 1992.
 
5) Hagino H, Okano T, Akhter MP, et al : Effect of parathyroid hormone on cortical bone response to in vivo external loading of the rat tibia. J Bone Miner Metab 19 : 244-250, 2001.
 
6) Milgrom C, Finestone A, Simkin A, et al : Invivo strain measurements to evaluate the strengthening potential of exercises on the tibial bone. J Bone Joint Surg Br 82 : 591-594, 2000.
 
7) Fukada E, Yasuda I : On the piezoelectric effect of bone. J Phys Soc Jpn 12 : 1158-1162, 1957.
 
8) Parfitt A, Michael MB, Chir B, et al : The cellular basis of bone turnover and bone loss : a rebuttal of the osteocytic resorption-bone flow theory. Clinical Orthopaedics & Related Researc 127 : 236-247, 1977.
 
9) Lanyon LE : Osteocytes, strain detection, bone modeling and remodeling. Calcif Tissue Int 53 Suppl 1 : S102-106, 1993.
 
10) Piekarski K, Munro M, et al : Transport mechanism operating between blood supply and osteocytes in long bones. Nature 269 : 80-82, 1977.
PubMed
11) Weinbaum S, Cowin SC, Zeng Y, et al : A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses. J Biomech 27 : 339-360, 1994.
 
12) Inoue D, Kido S, Matsumoto T : Transcriptional induction of FosB/DeltaFosB gene by mechanical stress in osteoblasts. J Biol Chem 279 : 49795-49803, 2004.
PubMed
13) Kim CH, You L, Yellowley CE, et al : Oscillatory fluid flow-induced shear stress decreases osteoclastogenesis through RANKL and OPG signaling. Bone 39 : 1043-1047, 2006.
PubMed
14) McGarry JG, Klein-Nulend J, Prendergast PJ : The effect of cytoskeletal disruption on pulsatile fluid flow-induced nitric oxide and prostaglandin E2 release in osteocytes and osteoblasts. Biochem Biophys Res Commun 330 : 341-348, 2005.
PubMed
15) Li YJ, Batra NN, You L, et al : Oscillatory fluid flow affects human marrow stromal cell proliferation and differentiation. J Orthop Res 22 : 1283-1289, 2004.
PubMed
16) Norvell SM, Alvarez M, Bidwell JP, et al : Fluid shear stress induces beta-catenin signaling in osteoblasts. Calcif Tissue Int 75 : 396-404, 2004.
PubMed
17) Klein-Nulend J, Helfrich MH, Sterck JG, et al : Nitric oxide response to shear stress by human bone cell cultures is endothelial nitric oxide synthase dependent. Biochem Biophys Res Commun 250 : 108-114 1998.
PubMed
18) McAllister TN, Frangos JA : Steady and transient fluid shear stress stimulate NO release in osteoblasts through distinct biochemical pathways. J Bone Miner Res 14 : 930-936, 1999.
PubMed
19) You J, Reilly GC, Zhen X, et al : Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts. J Biol Chem 276 : 13365-13371, 2001.
PubMed
20) Lu X L, Huo B, Park M, et al : Calcium response in osteocytic networks under steady and oscillatory fluid flow. Bone 51 : 466-473, 2012.
PubMed
21) Donahue SW, Jacobs CR, Donahue HJ : Flowinduced calcium oscillations in rat osteoblasts are age, loading frequency, and shear stress dependent. Am J Physiol Cell Physiol 281 : C1635-1641, 2001.
PubMed
22) Li J, Duncan RL, Burr DB, et al : L-type calcium channels mediate mechanically induced bone formation in vivo. J Bone Miner Res 17 : 1795-1800, 2002.
PubMed
23) Ryder KD, Duncan RL : Parathyroid hormone enhances fluid shear-induced [Ca2+] i signaling in osteoblastic cells through activation of mechanosensitive and voltage-sensitive Ca2+ channels. J Bone Miner Res 16 : 240-248, 2001.
PubMed
24) Malone AM, Batra NN, Shivaram G, et al : The role of actin cytoskeleton in oscillatory fluid flow-induced signaling in MC3T3-E1 osteoblasts. Am J Physiol Cell Physiol 292 : C1830-1836, 2007.
PubMed
25) Riddle RC, Taylor AF, Rogers JR, et al : ATP release mediates fluid flow-induced proliferation of human bone marrow stromal cells. J Bone Miner Res 22 : 589-600, 2007.
PubMed
26) Okumura H, Shiba D, Kubo T, et al : P2X7 receptor as sensitive flow sensor for ERK activation in osteoblasts. Biochem Biophys Res Commun 372 : 486-490, 2008.
PubMed
27) You J, Jacobs CR, Steinberg TH, et al : P2Y purinoceptors are responsible for oscillatory fluid flow-induced intracellular calcium mobilization in osteoblastic cells. J Biol Chem 277 : 48724-48729, 2002.
 
P.111 掲載の参考文献
1) Roesler H : Some historical remarks on the theory of cancellous bone structure (Wolff's law). In : Cowin SC (eds) : Mechanical Properties of Bone. AMD-45, Amer Soc Mech Engrs, 1981.
 
2) Currey JD : Bones. Princeton University Press, 2000.
 
3) Wang Y, McNamara LM, Schaffler MB, et al : A model for the role of intergrins in flow induced mechanotransduction in osteocytes. Proc Natl Acad Sci USA 104, 15941-15946, 2007.
 
4) Kapur S, Baylink DJ, Lau KH : Fluid flow shear stress stimulates human osteoblast proliferation and differentiation through multiple interacting and competing signal transduction pathways. Bone 32 : 241-251, 2003.
PubMed
5) Liu J, Liu T, Zheng Y, et al : Early responses of osteoblast-like cells to different mechanical signals through various signaling pathways. Biochem Biophys Res Commun 348 : 1167-1173, 2006.
PubMed
6) Rath B, Nam J, Knobloch TJ, et al : Compressive forces induce osteogenic gene expression in calvarial osteoblasts. J Biomech 41 : 1095-1103, 2008.
PubMed
7) Jacobs CR, Yellowley CE, Davis BR, et al : Differential effect of steady versus oscillating flow on bone cells. J Biomech 31 : 969-976, 1998.
 
8) Tanaka SM, Li J, Duncan RL, et al : Effects of broad frequency vibration on cultured osteoblasts. J Biomech 36 : 73-80, 2003.
PubMed
9) Tanaka SM, Sun HB, Roeder RK, et al : Osteoblast responses one hour after load-induced fluid flow in a three-dimensional porous matrix. Calcif Tissue Int 76 : 261-271, 2005.
 
10) Sukharev SI, Blount P, Martinac B, et al : Mechanosensitive channels of Escherichia coli : The MscL gene, protein, and activities. Annu Rev Physiol 59 : 633-657, 1997.
PubMed
11) Sokabe M, Sachs F, Jing Z : Quantitative video microscopy of patch clamped membranes stress, strain, capacitance, and stretch channel activation. Biophys J 59 : 722-728, 1991.
PubMed
12) Malone AMD, Anderson CT, Tummala P, et al : Primary cilia mediate mechanosensing in bone cells by a calcium independent mechanism. Proc Natl Acad Sci USA 104 : 13325-13330, 2007.
PubMed
13) Chen J, Liu C, You L, et al : Boning up on Wolff's law : Mechanical regulation of the cells that make and maintain bone. J Biomech 43 : 108-118, 2010.
 
P.114 掲載の参考文献
1) Burra S, Nicolella DP, Francis WL, et al : Dendritic processes of osteocytes are mechanotransducers that induce the opening of hemichannels. Proc Natl Acad Sci USA 107 : 13648-13653, 2010.
PubMed
2) Batra N, Kar R, Jiang JX : Gap junctions and hemichannels in signal transmission, function and development of bone. Biochim Biophys Acta 1818 : 1909-1918, 2012.
PubMed
3) Zhang Y, Paul EM, Sathyendra V, et al : Enhanced osteoclastic resorption and responsiveness to mechanical load in gap junction deficient bone. PLoS One 6 : e23516, 2011.
PubMed
4) Grimston SK, Goldberg DB, Watkins M, et al : Connexin43 deficiency reduces the sensitivity of cortical bone to the effects of muscle paralysis. J Bone Miner Res 26 : 2151-2160, 2011.
 
5) Salameh A, Dhein S : Effects of mechanical forces and stretch on intercellular gap junction coupling. Biochim Biophys Acta, 2012 [Epub ahead of print].
 
6) Lu XL, Huo B, Chiang V, et al : Osteocytic network is more responsive in calcium signaling than osteoblastic network under fluid flow. J Bone Miner Res 27 : 563-574, 2012.
 
7) Xiao Z, Dallas M, Qiu N, et al : Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice. FASEB J 25 : 2418-2432, 2011.
PubMed
8) Price C, Zhou X, Li W, et al : Real-time measurement of solute transport within the lacunar-canalicular system of mechanically loaded bone : direct evidence for load-induced fluid flow. J Bone Miner Res 26 : 277-285, 2011.
 
9) Temiyasathit S, Tang WJ, Leucht P, et al : Mechanosensing by the primary cilium : deletion of Kif3A reduces bone formation due to loading. PLoS One 7 : e33368, 2012.
PubMed
10) Hoey DA, Kelly DJ, Jacobs CR : A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells. Biochem Biophys Res Commun 412 : 182-187, 2011.
PubMed
11) Luo W, Xiong W, Zhou J, et al : Laminar shear stress delivers cell cycle arrest and anti-apoptosis to mesenchymal stem cells. Acta Biochim Biophys Sin (Shanghai) 43 : 210-216, 2011.
PubMed
12) Sarraf CE, Otto WR, Eastwood M : In vitro mesenchymal stem cell differentiation after mechanical stimulation. Cell Prolif 44 : 99-108, 2011.
PubMed
13) Battaglino RA, Sudhakar S, Lazzari AA, et al : Circulating sclerostin is elevated in short-term and reduced in long-term SCI. Bone 51 : 601-605, 2012.
 
14) Agholme F, Isaksson H, Li X, et al : Antisclerostin antibody and mechanical loading appear to influence metaphyseal bone independently in rats. Acta Orthop 82 : 628-632, 2011.
PubMed
15) Hinoi E, Ochi H, Takarada T, et al : Positive regulation of osteoclastic differentiation by growth differentiation factor 15 upregulated in osteocytic cells under hypoxia. J Bone Miner Res 27 : 938-949, 2012.
PubMed
16) Tu X, Rhee Y, Condon KW, et al : Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading. Bone 50 : 209-217, 2012.
PubMed
17) Riddle RC, Leslie JM, Gross TS, et al : Hypoxia-inducible factor-1α protein negatively regulates load-induced bone formation. J Biol Chem 286 : 44449-44456, 2011.
 
18) Morse LR, Sudhakar S, Danilack V, et al : Association between sclerostin and bone density in chronic spinal cord injury. J Bone Miner Res 27 : 352-359, 2012.
PubMed
19) Moustafa A, Sugiyama T, Prasad J, et al : Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered. Osteoporos Int 23 : 1225-1234, 2012.
 
20) Papapoulos SE : Targeting sclerostin as potential treatment of osteoporosis. Ann Rheum Dis 70 Suppl 1 : i119-122, 2011.
 
21) Mulcahy LE, Taylor D, Lee TC, et al : RANKL and OPG activity is regulated by injury size in networks of osteocyte-like cells. Bone 48 : 182-188, 2011.
 
22) Nakashima T, Hayashi M, Fukunaga T, et al : Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat Med 17 : 1231-1234, 2011.
PubMed
23) Xiong J, O'Brien CA : Osteocyte RANKL : new insights into the control of bone remodeling. J Bone Miner Res 27 : 499-505, 2012.
PubMed
24) Hamamura K, Swarnkar G, Tanjung N, et al : RhoA-Mediated Signaling in Mechanotransduction of Osteoblasts. Connect Tissue Res 53 : 398-406, 2012.
PubMed
25) Batra N, Burra S, Siller-Jackson AJ, et al : Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels. Proc Natl Acad Sci USA. 109 : 3359-3364, 2012.
 
26) Himeno-Ando A, Izumi Y, Yamaguchi A, et al : Structural differences in the osteocyte network between the calvaria and long bone revealed by three-dimensional fluorescence morphometry, possibly reflecting distinct mechano-adaptations and sensitivities. Biochem Biophys Res Commun 417 : 765-770, 2012.
PubMed
27) Kulkarni RN, Bakker AD, Gruber EV, et al : MT1-MMP modulates the mechanosensitivity of osteocytes. Biochem Biophys Res Commun 417 : 824-829, 2012.
PubMed
28) Watabe H, Furuhama T, Tani-Ishii N, et al : Mechanotransduction activates α5β1 integrin and PI3K/Akt signaling pathways in mandibular osteoblasts. Exp Cell Res 317 : 2642-2649, 2011.
 
29) Aghaloo TL, Chaichanasakul T, Bezouglaia O, et al : Osteogenic potential of mandibular vs. long-bone marrow stromal cells. J Dent Res 89 : 1293-1298, 2010.
PubMed
30) Kulkarni RN, Bakker AD, Everts V, et al : Inhibition of osteoclastogenesis by mechanically loaded osteocytes : involvement of MEPE. Calcif Tissue Int 87 : 461-468, 2010.
PubMed
31) Kamel MA, Picconi JL, Lara-Castillo N, et al : Activation of β -catenin signaling in MLOY4 osteocytic cells versus 2T3 osteoblastic cells by fluid flow shear stress and PGE2 : Implications for the study of mechanosensation in bone. Bone 47 : 872-881, 2010.
 
32) Li H, Liang CZ, Shen CC, et al : Decreases in fluid shear stress due to microcracks : a possible primary pathogenesis of Kummell's disease. Med Hypotheses 77 : 897-899, 2011.
 
33) Soicher MA, Wang X, Zauel RR, et al : Damage initiation sites in osteoporotic and normal human cancellous bone. Bone 48 : 663-666, 2011.
PubMed
34) Zhou H, Newnum AB, Martin JR, et al : Osteoblast/osteocyte-specific inactivation of Stat3 decreases load-driven bone formation and accumulates reactive oxygen species. Bone 49 : 404-411, 2011.
PubMed
35) Kulkarni RN, Bakker AD, Everts V, et al : Mechanical loading prevents the stimulating effect of IL-1β on osteocyte-modulated osteoclastogenesis. Biochem Biophys Res Commun 420 : 11-16, 2012.
 
36) Macias BR, Swift JM, Nilsson MI, et al : J Simulated resistance training, but not alendronate, increases cortical bone formation and suppresses sclerostin during disuse. Appl Physiol 112 : 918-925, 2012.
 
37) Fonseca H, Moreira-Goncalves D, Esteves JL, et al : Voluntary exercise has long-term in vivo protective effects on osteocyte viability and bone strength following ovariectomy. Calcif Tissue Int 88 : 443-454, 2011.
PubMed
38) Li J, Zhang F, Chen JY : An integrated proteomics analysis of bone tissues in response to mechanical stimulation. BMC Syst Biol 5 Suppl 3 : S7, 2011.
 
39) Trussel A, Muller R, Webster D : Toward Mechanical Systems Biology in Bone. Ann Biomed Eng 40 : 2475-2487, 2012.
PubMed
40) Kardas D, Nackenhorst U, Balzani D : Computational model for the cell-mechanical response of the osteocyte cytoskeleton based on self-stabilizing tensegrity structures. Biomech Model Mechanobiol, 2012 [Epub ahead of print].
 
41) Hambli R, Rieger R : Physiologically based mathematical model of transduction of mechanobiological signals by osteocytes. Biomech Model Mechanobiol 11 : 83-93, 2012.
PubMed
42) Varanasi SS, Olstad OK, Swan DC, et al : Skeletal site-related variation in human trabecular bone transcriptome and signaling. PLoS One 5 : e10692, 2010.
PubMed
P.121 掲載の参考文献
1) Li FJ, Kondo T, Zhao QL, et al : Enhancement of hyperthermia-induced apoptosis by a free radical initiator, 2,2'-azobis (2-amidinopropane) dihydrochloride, in human histiocytic lymphoma U937 cells. Free Radic Res 35 : 281-299, 2001.
PubMed
2) Yu DY, Zhao QL, Wei ZL, et al : Enhancement of hyperthermia-induced apoptosis by sanazole in human lymphoma U937 cells. Int J Hyperthermia 25 : 364-373, 2009.
PubMed
3) Takahashi A, Matsumoto H, Nagayama K, et al : Evidence for the involvement of doublestrand breaks in heat-induced cell killing. Cancer Res 64 : 8839-8845, 2004.
PubMed
4) Ohnishi T, Wang X, Ohnishi K, et al : p53-dependent induction of WAFI by heat treatment in human glioblastoma cells. J Biol Chem 271 : 14510-14513, 1996.
 
5) Dorion S, Lambert H, Landry J, et al : Activation of the p38 signaling pathway by heat shock involves the dissociation of glutathione S-transferase Mu from Ask1. J Biol Chem 277 : 30792-30797, 2002.
PubMed
6) Kurosaki H, Sakurai H, Mitsuhashi N, et al : Biological cell survival mapping for radiofrequency intracavitary irradiation. Jpn J Cancer Res 92 : 95-102, 2001.
PubMed
7) Hojo T, Fujioka M, Otsuka G, et al : Effect of heat stimulation on viability and proteoglycan metabolism of cultured chondrocytes : preliminary report. J Orthop Sci 8 : 396-369, 2003.
PubMed
8) Tonomura H, Takahashi KA, Mazda O, et al : Glutamine protects articular chondrocytes from heat stress and NO-induced apoptosis with HSP70 expression. Osteoarthritis Cartilage 14 : 545-553, 2006.
PubMed
9) Bardwell JC, Craig EA : Major heat shock gene of Drosophila and the Escherichia coli heat-inducible dnaK gene are homologous. Proc Natl Acad Sci USA 81 : 848-852, 1984.
PubMed
10) Hemmingsen SM, Woolford C, van der Vies SM, et al : Homologous plant and bacterial proteins chaperone oligomeric protein assembly. Nature 333 : 330-334, 1988.
PubMed
11) Ellis RJ, van der Vies SM : Molecular chaperones. Annu Rev Biochem 60 : 321-347, 1991.
PubMed
12) Wu C : Heat shock transcription factors : structure and regulation. Annu Rev Cell Dev Bio 11 : 441-469, 1995.
 
13) Calderwood SK, Xie Y, Wang X, et al : Signal Transduction Pathways Leading to Heat Shock Transcription. Sign Transduct Insights 2 : 13-24, 2010.
PubMed
14) Arai Y, Kubo T, Kobayashi K, et al : Adenovirus vector-mediated gene transduction to chondrocytes : in vitro evaluation of therapeutic efficacy of transforming growth factor-beta 1 and heat shock protein 70 gene transduction. J Rheumatol 24 : 1787-1795, 1997.
PubMed
15) Kubo T, Arai Y, Takahashi K, et al : Expression of transduced HSP70 gene protects chondrocytes from stress. J Rheumatol 28 : 330-335, 2001.
PubMed
16) Terauchi R, Takahashi KA, Arai Y, et al : Hsp70 prevents nitric oxide-induced apoptosis in articular chondrocytes. Arthritis Rheum 48 : 1562-1568, 2003.
PubMed
17) Grossin L, Etienne S, Gaborit N, et al : Induction of heat shock protein 70 (Hsp70) by proteosome inhibitor MG 132 protects articular chondrocytes from cellular death in vitro and in vivo. Biorheology 41 : 521-534, 2004.
 
18) Tonomura H, Takahashi KA, Mazda O, et al : Glutamine protects articular chondrocytes from heat stress and NO-induced apoptosis with HSP70 expression. Osteoarthritis Cartilage 14 : 545-553, 2006.
PubMed
19) Etienne S, Gaborit N, Henrionnet C, et al : Local induction of heat shock protein 70 (Hsp70) by proteosome inhibition confers chondroprotection during surgically induced osteoarthritis in the rat knee. Bio-medical Materials and Engineering 18 : 253-260, 2008.
 
20) Grossin L, Cournil-Henrionnet C, Pinzano A, et al : Gene transfer with HSP70 in rat chondrocytes confers cytoprotection in vitro and during experimental osteoarthritis. Faseb J 20 : 65-75, 2006.
PubMed
21) Takahashi K, Kubo T, Goomer RS, et al : Analysis of heat shock proteins and cytokines expressed during early stages of osteoarthritis in a mouse model. Osteoarthritis Cart 5 : 321-329, 1997.
 
22) Kubo T, Towle CA, Mankin HJ, et al : Stressinduced proteins in chondrocytes from patients with osteoarthritis. Arthritis Rheum 28 : 1140-1145, 1985.
PubMed
23) Calderwood SK, Murshid A, Prince T : The shock of aging : molecular chaperones and the heat shock response in longevity and aging--a mini-review. Gerontology 55 : 550-558, 2009.
PubMed
24) Caterina MJ, Schumacher MA, Tominaga M, et al : The capsaicin receptor : a heat-activated ion channel in the pain pathway. Nature 389 : 816-824, 1997.
PubMed
P.126 掲載の参考文献
1) Zhang S, Cheng J, Qin YX : Mechanobiological modulation of cytoskeleton and calcium influx in osteoblastic cells by short-term focused acoustic radiation force. PLoS One 7 : e38343, 2012.
 
2) Gong Y, Slee RB, Fukai N, et al : LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107 : 513-523, 2004.
 
3) Glass DA, Bialek P, Ahn JD et al : Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell 8 : 751-764, 2005.
PubMed
4) Holmen SL, Zylstra CR, Mukherjee A , et al : Essential role of beta-catenin in postnatal bone acquisition. J Biol Chem 280 : 21162-21168, 2005.
PubMed
5) Robinson JA, Chatterjee-Kishore M, Yaworsky PJ, et al : Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone. J Biol Chem 281 : 31720-31728, 2006.
 
6) Armstrong VJ, Muzylak M, Sunters A, et al : Wnt/beta-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha. J Biol Chem 282 : 20715-20727, 2007.
PubMed
7) Sawakami K, Robling AG, Ai M, et al : The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment. J Biol Chem 281 : 23698-23711, 2006.
 
8) Naruse K, Sekiya H, Harada Y, et al : Prolonged endochondral bone healing in senescence is shortened by low-intensity pulsed ultrasound in a manner dependent on COX-2. Ultrasound Med Biol 36 : 1098-1108, 2010.
 
9) Takeuchi R, Ryo A, Komitsu N, et al : Lowintensity pulsed ultrasound activates the phosphatidylinositol 3 kinase/Akt pathway and stimulates the growth of chondrocytes in three-dimensional cultures : a basic science study. Arthritis Res Ther 10 : R77, 2008.
PubMed
10) Watabe H, Furuhama T, Tani-Ishii N, et al : Mechanotransduction activates alpha (5) beta (1) integrin and PI3K/Akt signaling pathways in mandibular osteoblasts. Exp Cell Res 317 : 2642-2649, 2011.
PubMed
11) Olkku A, Leskinen JJ, Lammi MJ, et al : Ultrasound-induced activation of Wnt signaling in human MG-63 osteoblastic cells. Bone 47 : 320-330, 2010.
PubMed
12) Sawai Y, Murata H, Koto K, et al : Effects of low-intensity pulsed ultrasound on osteosarcoma and cancer cells. Oncol Rep 28 : 481-486, 2012.
PubMed
13) Norvell SM, Ponik SM, Bowen DK, et al : Fluid shear stress induction of COX-2 protein and prostaglandin release in cultured MC3T3-E1 osteoblasts does not require intact microfilaments or microtubules. J Appl Physiol 96 : 957-966, 2004.
PubMed
14) Weyts FA, Li YS, van LJ, et al : ERK activation and alpha v beta 3 integrin signaling through Shc recruitment in response to mechanical stimulation in human osteoblasts. J Cell Biochem 87 : 85-92, 2002.
 
15) Bandow K, Nishikawa Y, Ohnishi T, et al : Low-intensity pulsed ultrasound (LIPUS) induces RANKL, MCP-1, and MIP-1beta expression in osteoblasts through the angiotensinII type 1 receptor. J Cell Physiol 211 : 392-398, 2007.
 
16) Borsje MA, Ren Y, Haan-Visser HW, et al : Comparison of low-intensity pulsed ultrasound and pulsed electromagnetic field treatments on OPG and RANKL expression in human osteoblast-like cells. Angle Orthod 80 : 498-503, 2010.
PubMed
17) Yang RS, Lin WL, Chen YZ, et al : Regulation by ultrasound treatment on the integrin expression and differentiation of osteoblasts. Bone 36 : 276-283, 2005.
PubMed
18) Nakashima T, Hayashi M, Fukunaga T, et al : Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat Med 17 : 1231-1234, 2011.
PubMed
19) Cheung WH, Chow SK, Sun MH, et al : Lowintensity pulsed ultrasound accelerated callus formation, angiogenesis and callus remodeling in osteoporotic fracture healing. Ultrasound Med Biol 37 : 231-238, 2011.
PubMed
20) Lirani-Galvao AP, Jorgetti V, da Silva OL : Comparative study of how low-level laser therapy and low-intensity pulsed ultrasound affect bone repair in rats. Photomed Laser Surg 24 : 735-740, 2006.
 
21) Rutten S, Nolte PA, Korstjens CM, et al : Low-intensity pulsed ultrasound increases bone volume, osteoid thickness and mineral apposition rate in the area of fracture healing in patients with a delayed union of the osteotomized fibula. Bone 43 : 348-354, 2008.
PubMed
22) Sun JS, Hong RC, Chang WH, et al : In vitro effects of low-intensity ultrasound stimulation on the bone cells. J Biomed Mater Res 57 : 449-456, 2002.
 
23) Rego EB, Inubushi T, Miyauchi M, et al : Ultrasound stimulation attenuates root resorption of rat replanted molars and impairs tumor necrosis factor-α signaling in vitro. J Periodontal Res 46 : 648-654, 2011.
 
24) Nakamura T, Fujihara S, Yamamoto-Nagata K, et al : Low-intensity pulsed ultrasound reduces the inflammatory activity of synovitis. Ann Biomed Eng 39 : 2964-2971, 2011.
PubMed
25) Wang FS, Kuo YR, Wang CJ, et al : Nitric oxide mediates ultrasound-induced hypoxiainducible factor-1alpha activation and vascular endothelial growth factor-A expression in human osteoblasts. Bone 35 : 114-123, 2004.
PubMed
26) Tang CH, Lu DY, Tan TW, et al : Ultrasound induces hypoxia-inducible factor-1 activation and inducible nitric-oxide synthase expression through the integrin/integrinlinked kinase/Akt/mammalian target of rapamycin pathway in osteoblasts. J Biol Chem 282 : 25406-25415, 2007.
PubMed
27) Tang CH, Yang RS, Huang TH, et al : Ultrasound stimulates cyclooxygenase-2 expression and increases bone formation through integrin, focal adhesion kinase, phosphatidylinositol 3-kinase, and Akt pathway in osteoblasts. Mol Pharmacol 69 : 2047-2057, 2006.
PubMed
28) Miyauchi A, Gotoh M, Kamioka H, et al : AlphaVbeta3 integrin ligands enhance volume-sensitive calcium influx in mechanically stretched osteocytes. J Bone Miner Metab 24 : 498-504, 2006.
PubMed
29) Miyauchi A, Notoya K, Mikuni-Takagaki Y, et al : Parathyroid hormone-activated volume-sensitive calcium influx pathways in mechanically loaded osteocytes. J Biol Chem 275 : 3335-3342, 2000.
PubMed
30) Naruse K, Miyauchi A, Itoman M, et al : Distinct anabolic response of osteoblast to low-intensity pulsed ultrasound. J Bone Miner Res 18 : 360-369, 2003.
PubMed
31) Sakamoto K, Arnolds DE, Ekberg I , et al : Exercise regulates Akt and glycogen synthase kinase-3 activities in human skeletal muscle. Biochem Biophys Res Commun 319 : 419-425, 2004.
PubMed
32) Khanna A, Nelmes RT, Gougoulias N, et al : The effects of LIPUS on soft-tissue healing : a review of literature. Br Med Bull 89 : 169-182, 2009.
PubMed
33) Zhou S, Schmelz A, Seufferlein T, et al : Molecular mechanisms of low intensity pulsed ultrasound in human skin fibroblasts. J BiolChem 279 : 54463-54469, 2004.
 
34) Caswell PT, Vadrevu S, Norman JC : Integrins : masters and slaves of endocytic transport. Nat Rev Mol Cell Biol : 10 : 843-853, 2009.
PubMed
35) Jun HK, Lee SH, Lee HR, et al : Integrin α5β1 activates the NLRP3 inflammasome by direct interaction with a bacterial surface protein. Immunity 36 : 755-768, 2012.
 
36) Bass MD, Williamson RC, Nunan RD et al : A syndecan-4 hair trigger initiates wound healing through caveolin- and RhoGregulated integrin endocytosis. Dev Cell 21 : 681-693, 2011.
PubMed
37) Mahoney CM, Morgan MR, Harrison A, et al : Therapeutic ultrasound bypasses canonical syndecan-4 signaling to activate rac1. J Biol Chem 284 : 8898-8909, 2009.
PubMed
38) Sena K, Leven RM, Mazhar K, et al : Early gene response to low-intensity pulsed ultrasound in rat osteoblastic cells. Ultrasound Med Biol 31 : 703-708, 2005.
PubMed
39) Ikeda K, Takayama T, Suzuki N, et al : Effects of low-intensity pulsed ultrasound on the differentiation of C2C12 cells. Life Sci 79 : 1936-1943, 2006.
PubMed
40) Takayama T, Suzuki N, Ikeda K, et al : Lowintensity pulsed ultrasound stimulates osteogenic differentiation in ROS 17/2. 8 cells. Life Sci 80 : 965-971, 2007.
PubMed
41) Hasegawa T, Miwa M, Sakai Y, et al : Osteogenic activity of human fracture haematoma-derived progenitor cells is stimulated by low-intensity pulsed ultrasound in vitro. J Bone Joint Surg Br 91 : 264-270, 2009.
PubMed
42) Unsworth J, Kaneez S, Harris S, et al : Pulsed low intensity ultrasound enhances mineralisation in preosteoblast cells. Ultrasound Med Biol 33 : 1468-1474, 2007.
PubMed
43) Kumagai K, Takeuchi R, Ishikawa H, et al : Low-intensity pulsed ultrasound accelerates fracture healing by stimulation of recruitment of both local and circulating osteogenic progenitors. J Orthop Res 30 : 1516-1521, 2012.
PubMed
44) Huiskes R : If bone is the answer, then what is the question? J Anat 197 (Pt 2) : 145-156, 2000.
 
P.134 掲載の参考文献
1) Saito M, Marumo K : Collagen cross-links as a determinant of bone quality : a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus. Osteoporos Int 21 : 195-214. 2010, Review.
PubMed
2) Saito M, Soshi S, Tanaka T, et al : Intensityrelated differences in collagen post-traslational modification in MC3T3-E1 osteoblasts after exposure to low and high intensity pulsed ultrasound. Bone 35 : 644-655, 2004.
 
3) Saito M, Fujii K, Tanaka T, et al : Effect of low- and high-intensity pulsed ultrasound on collagen post-translational modifications in MC3T3-E1 Osteoblasts. Calcif Tissue Int 75 : 384-385, 2004.
PubMed
4) Maruhashi T, Kii I, Saito M, et al : Interaction between periostin and BMP-1 promotes proteolytic activation of lysyl oxidase. J Biol Chem 85 : 13294-13303. 2010.
 
5) Saito M, Mori S, Mashiba T, et al : Collagen maturity, glycation induced pentosidine, and mineralization are increased following 3-years treatment of incadronate in dogs. Osteoporos Int 19 : 1343-1354, 2009.
 
6) Saito M, Fujii K, Soshi S et al : Reductions in degree of mineralization and enzymatic collagen cross-links and increases in glycation induced pentosidine in the femoral neck cortex in cases of femoral neck fracture. Osteoporos Int 17 : 986-995, 2006.
PubMed
7) Saito M, Fujii K, Marumo K : Degree of mineralization-related collagen crosslinking in the femoral neck cancellous bone in cases of hip fracture and controls. Calcif Tissue Int 79 : 160-168, 2006.
PubMed
8) Saito M, Fujii K, Mori Y, et al : Role of collagen enzymatic and glycation induced cross-links as a determinant of bone quality in the spontaneously diabetic WBN/Kob rats. Osteoporos Int 17 : 1514-1523, 2006.
PubMed
9) Saito M, Marumo K, Soshi S, et al : Raloxifene ameliorates detrimental collagen cross-link formation and bone strength in rabbits with hyperhomocysteinemia. Osteoporos Int 21 : 655-666, 2010.
PubMed
10) Saito M, Shiraishi A, Ito M, et al : Comparison of effects of alfacalcidol and alendronate on mechanical properties and bone collagen cross-links of callus in the fracture repair rat model. Bone 2010 46 : 1170-1179, 2010.
PubMed
11) Saito M, Marumo K, Kida Y, et al : Changes in the contents of enzymatic immature, mature, and non-enzymatic senescent cross-links of collagen after once-weekly treatment with human parathyroid hormone (1-34) for 18 months contribute to improvement of bone strength in ovariectomized monkeys. Osteoporos Int 22 : 2373-2383, 2011.
PubMed
12) Marumo K, Saito M, Yamagishi T, et al : The ligamentization process in human anterior cruciate ligament reconstruction with autogenous patellae and hamstring tendon-A biochemical study-. Am J Sports Med 33 : 1166-1173, 2005.
 
13) Saito M, Marumo K, Fujii K, et al : Single column high-performance liquid chromatographic-fluorescence detection of immature, mature and senescent cross-links of collagen. Anal Biochem 253 : 26-32, 1997.
PubMed
14) Saito M, Soshi S, Fujii K : Effect of hyper-and microgravity on collagen post-translational controls of MC3T3-E1 osteoblasts. J Bone Miner Res 18 : 1695-1705, 2003.
PubMed
15) Wassen MH, Lammens J, Tekoppele JM, et al : Collagen structure regulates fibril mineralization in osteogenesis as revealed by cross-link patterns in calcifying callus. J Bone Miner Res 15, 1776-1785, 2000.
PubMed
16) Saito M, Fujii K, Marumo K : Degree of mineralization-related collagen crosslinking in the femoral neck cancellous bone in cases of hip fracture and controls. Calcif Tissue Int 79 : 160-168, 2006.
PubMed
17) Kume S, Kato S, Yamagishi S : Advanced glycation end-products attenuate human mesenchymal stem cells and prevent cognate differentiation into adipose tissue, cartilage, and bone. J Bone Miner Res 20 : 1647-1658, 2005.
 
P.141 掲載の参考文献
1) Ilizarov GA : The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation. Clin Orthop Relat Res 238 : 249-281, 1989.
PubMed
2) Ilizarov GA : The tension-stress effect on the genesis and growth of tissues : Part II. The influence of the rate and frequency of distraction. Clin Orthop Relat Res 239 : 263-285, 1989.
PubMed
3) Rockwood CA, Green DP, Bucholz RW : Rockwood and Green's fractures in adults. 6th ed, Lippincott Williams & Wilkins, 2006.
 
4) Gerstenfeld LC, Cullinane DM, Barnes GL, et al : Fracture healing as a post-natal developmental process : molecular, spatial, and temporal aspects of its regulation. J Cell Biochem 88 : 873-884, 2003.
PubMed
5) Taylor DK, Meganck JA, Terkhorn S, et al : Thrombospondin-2 influences the proportion of cartilage and bone during fracture healing. J Bone Miner Res 24 : 1043-1054, 2009.
PubMed
6) Kojimoto H, Yasui N, Goto T, et al : Bone lengthening in rabbits by callus distraction. The role of periosteum and endosteum. J Bone Joint Surg Br 70 : 543-549, 1988.
PubMed
7) Sato M, Ochi T, Nakase T, et al : Mechanical tension-stress induces expression of bone morphogenetic protein (BMP) -2 and BMP-4, but not BMP-6, BMP-7, and GDF-5 mRNA, during distraction osteogenesis. J Bone Miner Res 14 : 1084-1095, 1999.
 
8) Yasui N, Sato M, Ochi T, et al : Three modes of ossification during distraction osteogenesis in the rat. J Bone Joint Surg Br 79 : 824-830, 1997.
 
9) Pacicca DM, Patel N, Lee C, et al : Expression of angiogenic factors during distraction osteogenesis. Bone 33 : 889-898, 2003.
PubMed
10) Takahashi M, Yukata K, Matsui Y, et al : Bisphosphonate modulates morphological and mechanical properties in distraction osteogenesis through inhibition of bone resorption. Bone 39 : 573-581, 2006.
PubMed
11) Yasui N, Kojimoto H, Shimizu H, et al : The effect of distraction upon bone, muscle, and periosteum. Orthop Clin North Am 22 : 563-567, 1991.
PubMed
12) Williams P, Watt P, Bicik V, et al : Effect of stretch combined with electrical stimulation on the type of sarcomeres produced at the ends of muscle fibers. Exp Neurol 93 : 500-509, 1986.
PubMed
13) Dix DJ, Eisenberg BR : Myosin mRNA accumulation and myofibrillogenesis at the myotendinous junction of stretched muscle fibers. J Cell Biol 111 : 1885-1894, 1990.
PubMed
14) Takahashi M, Sakamoto H, Nishioka K, et al : Impaired architectural adaptations in plantarflexor muscles to accelerated limb lengthening. Proceeding of Annual Meeting of Orthopaedic Research Association, 2011.
 
15) Maeda E, Ye S, Wang W, et al : Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading. Biomech Model Mechanobiol 11-3-4 : 439-447, 2012.
 
16) Kjaer M, Magnusson P, Krogsgaard M, et al : Extracellular matrix adaptation of tendon and skeletal muscle to exercise. J Anat 208 : 445-450, 2006.
PubMed
17) Archambault JM, Hart DA, Herzog W : Response of rabbit Achilles tendon to chronic repetitive loading. Connect Tissue Res 42 : 13-23, 2001.
PubMed
18) Williams P, Kyberd P, Simpson H, et al : The morphological basis of increased stiffness of rabbit tibialis anterior muscles during surgical limb-lengthening. J Anat 193 (Pt 1) : 131-138, 1998.
 

基礎III 生体電気・物理刺激の基礎研究

P.153 掲載の参考文献
1) 保田岩夫 : 生体骨の圧電気現象に就て. 京都府立医大誌 53 : 325-326, 1953.
 
2) Brighton CT, Friedenberg ZB, Black J, et al : Electrically induced osteogenesis : relationship between charge, current density, and the amount of bone formed : introduction of a new cathode concept. Clin Orthop Relat Res 161 : 122-132, 1981.
PubMed
3) Friedenberg ZB, Brighton CT, Michelson JD, et al : The effects of demineralized bone matrix and direct current on an "in vivo" culture of bone marrow cells. J Orthop Res 7 : 22-27, 1989.
 
4) Bassett CA : Pulsing electromagnetic fields : a new method to modify cell behavior in calcified and noncalcified tissues. Calcif Tissue Int 34 : 1-8, 1982.
PubMed
5) Brighton CT, Friedenberg ZB, Zemsky LM, et al : Direct-current stimulation of non-union and congenital pseudarthrosis. Exploration of its clinical application. J Bone Joint Surg 57-A : 368-377, 1975.
PubMed
6) Bassett CA, Pilla AA, Pawluk RJ : A non-operative salvage of surgically-resistant pseudarthroses and non-unions by pulsing electromagnetic fields : A preliminary report. Clin Orthop 124 : 128-143, 1977.
PubMed
7) Bassett CA, Mitchell SN, Gaston SR : Treatment of ununited tibial diaphyseal fractures. J Bone Joint Surg 63-A : 511-523, 1981.
PubMed
8) Bassett CA, Caulo N, Kort J : Acceleration of fracture repair by eledromagnetic field : A surgically noninvasive method. Ann NY Acad Sci 238 : 242-262, 1974.
 
9) Brighton CT , Black J, Friedenberg ZB, et al : A multicenter study of the treatment of non-union with constant direct current. J Bone Joint Surg 62-A : 2-13, 1981.
 
10) 湯川佳宣, 真野淳, 津田欣徳, 他 : 交流電気刺激による難治性骨折の治療. 整・災外 25 : 385-404, 1982.
 
11) Brighton CT, Pollac SR : Treatment of recalcitrant non-union with a capacitively coupled electrical field, a preliminary report. J Bone Joint Surg 67-A : 577-585, 1985.
 
12) Heckman JD, Ryaby JP, McCabe J, et al : Acceleration of tibial fracture-healing by non-invasive, low-intensity pulsed ultrasound. J Bone Joint Surg 76-A : 26-34, 1994.
PubMed
13) Augat P, Claes L, Suger G : In vivo effect of shock-waves on the healing of fractured bone. Clin Biomech 10 : 374-378, 1995.
PubMed
14) Matsunaga S : Histological and histochemical investigations of constant direct current stimulated intramedullary callus. J Jpn Orthop Ass 60 : 1293-1303, 1986.
 
15) 松永俊二, 他 : 電気刺激による骨形成促進機序についての免疫組織学的観察. 別冊整形外科 18 : 88-92, 1990.
 
16) 松永俊二, 井尻幸成, 酒匂崇, 他 : 電気刺激による骨形成機序について. 臨床整形外科 27 : 1349-1355, 1992.
 
17) Matsunaga S, Ijiri K, Sakou T, et al : Immunohistochemical study of activating osteoblasts from undifferentiated mesenchymal cells by electrical stimulation. Bone 14 : 327-332, 1993.
PubMed
18) Yonemori K, Matsunaga S, Ishidou Y, et al : Early effects of electrical stimulation on osteogeneis. Bone 19 : 173-180, 1996
 
19) Howell WM, Black DA : Controlled silverstaining of nucleolus organizer regions with a protective colloidal developer : a 1-step method. Experientia 36 : 1014-1015, 1980.
PubMed
20) Ijiri K, Matsunaga S, Fukuda T, et al : Indomethacin inhibition of ossification induced by direct current stimulation. J Orthop Res 13 : 123-131, 1995.
PubMed
21) 井上四郎, 大橋俊郎, 梶川究, 他 : 骨への分化に対する電気刺激の影響. 整形外科基礎科学 7 : 501-507, 1980.
 
22) Bourguignon GJ, Bourguignon LY : Electric stimulation of protein and DNA synthesis in human fibroblasts. FASEB J 1 : 398-402, 1987.
PubMed
23) Brighton CT, Adler S, Black J, et al : Cathodic oxygen consumption and electrically induced osteogenesis. Clin Orthop Relat Res 107 : 277-282, 1975
PubMed
24) Morita I, Toriyama K, Murota S : Effeds of prostaglandin E2 on phenotype of osteoblastslike cells. Adv Prostaglandin Thromboxane Leukot Res 19 : 419-422, 1989.
 
25) 石堂康弘, 酒匂崇 : 電気仮骨におけるTGF-βの経時的変化. 生体電気刺激研究会誌, 93 : 859-863, 1994
 
P.159 掲載の参考文献
1) 保田岩夫 : 骨折治療に関する基礎的諸問題. 京都医学会 4 : 395-406, 1953.
 
2) Fukada E, Yasuda I : On the Piezoelectric Effect of Bone. J Phys Soc Jpn 12 : 1158-1162, 1957.
 
3) Fukada E, Yasuda I : Piezoelectric Effects in Collagen. Jap J Appl Physiol 3 : 117-121, 1964.
 
4) Becker RO : The bioelecttric factors in amphibian-limb regeneration. J Bone Joint Surg [Am] 43 : 643-656, 1961.
PubMed
5) Smith SO : Induction of partial limb regeneration in Rana pipiens by galvanic stimulation. Anat Rec 158 : 89, 1967.
 
6) Becker RO : Stimulation of partial limb regeneration in rats. Nature 235 : 109-111, 1972.
PubMed
7) Becker RO, Sapadaro JA : Electrical stimulation of partial limb regeneration in mammals, Bull NY Acad Med 48 : 627-641, 1972.
 
8) Norrie RD : A preliminary report on regenerative healing in the equine tendon. Am J Ver Res 36 : 1523-1524, 1975.
 
9) Stanish WD, Rubinovich M, Kozey J, et al : The use of electricity in ligament and tendon repair. Physician sports Med 13 : 109-116, 1985.
 
10) Owoeye I, Spielhorz NI, Nelson AJ : Lowintensity Pulsed Galvanic Current and the Healing of Tenotomized Rat Achilles tendons : Preliminary Report Using Load-to-Breaking Measurements, Arch Phys Med Rehabili 69 : 415-418, 1987.
 
11) Akai M, Oda H, Shirasaki Y, et al : Electrical Stimulation of Ligament Healing, Clin Orthop Res Soc 13 : 106, 1988.
 
12) Adams EL, Bradford DS, ZOegema TR : Earley histological and biomechanical change in ligament healing under electrical stimulation. Trans Orthop Res soc 13 : 106, 1988.
 
13) Litke DS, Dahners LE : Effects of Different Levels of Direct Current on Early Ligament Healing in a Rat Model. J Orthop Res 12 : 683-688, 1994.
 
14) Chan HK, Fung DT, Ng GY : Effects of Low-Voltage Microamperage Stimulation on Tendon Healing in Rats. J Orthop Sports Phys Ther 37 : 399-403, 2007.
PubMed
15) 大井優紀, 井上基浩, 中島美和, 他 : ラットのアキレス腱修復に与える鍼通電刺激の効果. 日本温泉気候物理医学会 75 : 112-123, 2012.
Medical*Online
16) Nessler JP, Mass DP : Direct-Current Electrical Stimulation of Tendon Healing in Vitro. Clin Orthop Relat Res 217 : 303-312, 1987.
PubMed
17) Fujita M, Hukuda S, Doida Y : The effect of constant Dicrect Electrical Current on intrinsic healing in the flexor tendon in vitro. J of Hand Surgery 17B : 94-98, 1992.
 
18) Cheng N, Van Hoof H, Bockx E, et al : The effects of electric currents on ATP generation, protein synthesis, and membrane transport of rat skin. Clin Orthop Relat Res 171 : 264-272, 1982.
PubMed
19) Bourguignon GL, Bourguignon LY : Electric stimulation of protein and DNA synthesis in human fibroblast. FASEB J 1 : 398-402, 1987.
 
20) Inoue M, Katsumi Y, Ito M, et al : Direct current electrical stimulation of acupuncture needles for peripheral nerve regeneration. Acupunct Med 29 : 88-93, 2011.
 
P.165 掲載の参考文献
1) Marsh G, Beams HW : In vitro control of growing chick nerve fibers by applied electric currents. J Cell Physiol 27 : 139-157, 1946.
 
2) Hoffman H : Acceleration and retardation of the process of axon-sprouting in partially devervated muscles. Aust J Exp Biol Med Sci 30 : 541-566, 1952.
PubMed
3) Borgens RB, Vanable JW, Jr, Jaffe LF : Bioelectricity and regeneration. I. Initiation of frog limb regeneration by minute currents. J Exp Zool 200 : 403-416, 1977.
PubMed
4) Pomeranz B, Mullen M, Markus H : Effect of applied electrical fields on sprouting of intact saphenous nerve in adult rat. Brain Res 303 : 331-336, 1984.
PubMed
5) McDevitt L, Fortner P, Pomeranz B : Application of weak electric field to the hindpaw enhances sciatic motor nerve regeneration in the adult rat. Brain Res 416 : 308-314, 1987.
 
6) Pomeranz B, Campbell JJ : Weak electric current accelerates motoneuron regeneration in the sciatic nerve of ten-month-old rats. Brain Res 603 : 271-278, 1993.
PubMed
7) Borgens RB, Blight AR, McGinnis ME : Behavioral recovery induced by applied electric fields after spinal cord hemisection in guinea pig. Science 238 : 366-369, 1987.
PubMed
8) Kerns JM, Pavkovic IM, Fakhouri AJ, et al : An experimental implant for applying a DC electrical field to peripheral nerve. J Neurosci Methods 19 : 217-223, 1987.
 
9) Nix WA, Hopf HC : Electrical stimulation of regenerating nerve and its effect on motor recovery. Brain Res 272 : 21-25, 1983.
PubMed
10) Pockett S, Gavin RM : Acceleration of peripheral nerve regeneration after crush injury in rat. Neurosci Lett 59 : 221-224, 1985.
PubMed
11) Al-Majed AA, Neumann CM, Brushart TM, et al : Brief electrical stimulation promotes the speed and accuracy of motor axonal regeneration. J Neurosci 20 : 2602-2608, 2000.
PubMed
12) Geremia NM, Gordon T, Brushart TM, et al : Electrical stimulation promotes sensory neuron regeneration and growth-associated gene expression. Exp Neurol 205 : 347-359, 2007.
PubMed
13) English AW, Schwartz G, Meador W, et al : Electrical stimulation promotes peripheral axon regeneration by enhanced neuronal neurotrophin signaling. Dev Neurobiol 67 : 158-172, 2007.
PubMed
14) Al-Majed AA, Brushart TM, Gordon T : Electrical stimulation accelerates and increases expression of BDNF and trkB mRNA in regenerating rat femoral motoneurons. Eur J Neurosci 12 : 4381-4390, 2000.
PubMed
15) Patel N, Poo MM : Orientation of neurite growth by extracellular electric fields. J Neurosci 2 : 483-496, 1982.
 
16) Ming G, Henley J, Tessier-Lavigne M, et al : Electrical activity modulates growth cone guidance by diffusible factors. Neuron 29 : 441-452, 2001.
PubMed
17) Stevens B, Fields RD : Response of Schwann cells to action potentials in development. Science 287 : 2267-2271, 2000.
PubMed
18) Huang J, Ye Z, Hu X, et al : Electrical stimulation induces calcium-dependent release of NGF from cultured Schwann cells. Glia 58 : 622-631, 2010.
PubMed
19) Morimoto T, Miyoshi T, Fujikado T, et al : Electrical stimulation enhances the survival of axotomized retinal ganglion cells in vivo. Neuroreport 13 : 227-230, 2002.
PubMed
20) Lal D, Hetzler LT, Sharma N, et al : Electrical stimulation facilitates rat facial nerve recovery from a crush injury. Otolaryngol Head Neck Surg 139 : 68-73, 2008.
PubMed
21) Asensio-Pinilla E, Udina E, Jaramillo J, et al : Electrical stimulation combined with exercise increase axonal regeneration after peripheral nerve injury. Exp Neurol 219 : 258-265, 2009.
PubMed
22) Sharma N, Marzo SJ, Jones KJ, et al : Electrical stimulation and testosterone differentially enhance expression of regeneration-associated genes. Exp Neurol 223 : 183-191, 2010.
PubMed
23) Huang J, Lu L, Zhang J, et al : Electrical stimulation to conductive scaffold promotes axonal regeneration and remyelination in a rat model of large nerve defect. PLoS One 7 : e39526, 2012.
 
24) Baptista AF, Gomes JR, Oliveira JT, et al : High- and low-frequency transcutaneous electrical nerve stimulation delay sciatic nerve regeneration after crush lesion in the mouse. J Peripher Nerv Syst 13 : 71-80, 2008.
PubMed
25) Sasaki K, Matsunaga T, Tomite T, et al : Effect of electrical stimulation therapy on upper extremity functional recovery and cerebral cortical changes in patients with chronic hemiplegia. Biomed Res 33 : 89-96, 2012.
PubMed
P.172 掲載の参考文献
1) 保田岩夫, 永山壽, 加藤常行, 他 : 骨折治療に関する基礎的諸問題. 京都医学会雑誌 4 : 395-406, 1953.
 
2) 保田岩夫, 飯田瞳, 野口和彦 : 交流による電気的仮骨. 日整会誌 29 : 89, 1955.
Medical*Online
3) 飯田瞳, 高舜探, 宮下義郎, 他 : 交流による電気的仮骨. 京府医大誌 60 : 561, 1956.
 
4) Wittebol P : Stimulation of non-epiphyseal bone growth. Calcif Tissue Res Suppl 4 : 122, 1970.
 
5) 湯川佳宣, 水田隆之 : 交流電気刺激法, 直達式. (生体電気刺激研究会編 : 電気刺激による骨・軟部組織修復の促進 その基礎と応用). pp63-91, 文光堂, 1993.
 
6) 代田雅彦, 小林雅文, 山田哲也, 他 : 上腕骨近位部骨折に対する骨交流電気刺激装置付き創外固定器の有用性について. 骨折 27 : 262-267, 2005.
Medical*Online
7) Itoh S, Ohta T, Sekino Y, et al : Treatment of distal radius fractures with a wrist-bridging external fixation : the value of alternating electric current stimulation. J Hand Surg Eur 33 : 605-608, 2008.
PubMed
8) 亀山真, 斉藤憲太, 手塚正樹 : 橈骨遠位端骨折に対するnon-bridging創外固定法における骨電気刺激の有用性. 骨折 31 : 130-133, 2009.
Medical*Online
9) 湯川佳宣, 真野淳, 津田欣徳, 他 : 交流電気刺激による難治性骨折の治療. 整形・災害外科 25 : 385-404, 1982.
 
10) Kawamoto K, Kim WC, Tsuchida Y, et al : Effects of alternating current electrical stimulation on lengthening callus. J Pediatr Orthop B 14 : 299-302, 2005.
PubMed
11) Yoshida T, Kim WC, Hirashima T, et al : 10μ A electrical stimulation for 20 minutes maintains bone mineral density of lengthening callus. Trans Orthop Res Soc 34 : 2149, 2009.
 
12) Eyres KS, Bell MJ, Kanis JA : New bone formation during leg lengthening. Evaluated by dual energy X-ray absorptiometry. J Bone Joint Surg Br 75 : 96-106, 1993.
PubMed
13) Yoshida T, Kim WC, Oka Y, et al : Assessment of distraction callus in rabbits by monitoring of the electrical impedance of bone. Acta Orthop 81 : 628-633, 2010.
PubMed
14) Miyatani M, Kanehisa H, Masuo Y, et al : Validity of estimating limb muscle volume by bioelectrical impedance. J Appl Physiol 91 : 386-394, 2001.
PubMed
15) Ohmine Y, Morimoto T, Kinouchi Y, et al : Basic study of new diagnostic modality according to non-invasive measurement of the electrical conductivity of tissues. J Med Invest 51 : 218-225, 2004.
PubMed
16) Yoshida T, Kim WC, Kawamoto K, et al : Measurement of bone electrical impedance in fracture healing. J Orthop Sci 14 : 320-329, 2009.
PubMed
17) Hirashima T, Kim WC, Kawamoto K, et al : Evaluating of bone union of distal radius fractures by measuring impedance values. Orthopedics 32 : 31-33, 2009.
PubMed
18) 吉田隆司, 金郁吉, 岡佳伸, 他 : 長管骨の骨成熟過程におけるインピーダンス値の検討. 日本創外固定・骨延長学会雑誌 21 : 29-33, 2010.
 
P.179 掲載の参考文献
1) 保田岩男, 永山寿, 加藤常行, 他 : 骨折治療に関する基礎的諸問題. 京都医会誌 4 : 395-406, 1953.
 
2) Bassett CA, Hermann I : The effect of electrostatic fields on macromolecular synthesis by fibroblasts in vitro. J Cell Biol 39 : 9-a, 1968.
 
3) Bassett CA, Michel SN, Gaston SR : Treatment of ununited tibial diaphyseal fractures with pulsing electromagnetic fields. J Bone Joint Surg 63-A : 511-523, 1981.
 
4) Bassett CA : The development and application of pulsing electromagnetic fields (PEMF) for ununited fracture and arthrodesis. Orthop Clin North Am 15 : 61-87, 1984.
PubMed
5) Kodama H, Amagai Y, Yamamoto S, et al : Establishment of a clonal osteogenic cell line from newborn mouse calvaria. Jpn J Oral Biol 23 : 899-901, 1981.
 
6) 正岡利紀 : 骨芽細胞様細胞株 (MC3T3-E1) に対する変動電磁場の及ぼす影響. 東医大誌 53 : 336-345, 1995.
 
7) Mayahara H, Hirano H, Saito T, et al : The new lead citrate method for the ultracytochemical demonstration of non-specific alkaline phosphatase. Histochemie 11 : 88-96, 1967.
PubMed
8) 正田健次郎 : 骨芽細胞様細胞株 (MC3T3-E1) のTGF-β 産生能ならびに細胞内Ca++動態に対する変動電磁場の影響. 東医大誌 55 : 297-306, 1997
 
9) 曽我真 : 変動電磁場が骨芽細胞様細胞株 (MC3T3-E1) の細胞外基質に及ぼす影響. 東医大誌 55 : 500-509, 1997.
 
10) Miyagawa N, Yamamoto K, Masaoka T, et al : Effect of pulsing electromagnetic field stimulation on the productions of insulin-like growth factor-I (IGF-I) and IGF-I receptor in osteoblast-like cells. J Tokyo Med Univ 61 : 496-502, 2003.
 
11) Brighton CT, Hunt RM : Early histologic and ultrastructural changes in microvessels of periosteal callus. J of Orthop Trauma 11 : 244-235, 1997.
PubMed
12) Yang Y, Tao C, Zhao D, et al : EMF acts on rat bone marrow mesenchymal stem cells to promote differentiation to osteoblasts and to inhibit differentiation to adipoctes. Bioelectromagnetics 31 : 277-285, 2010.
 
13) Spadaro JA : Electrical osteogenesis ; Role of electrical material ; Electrical properties of bone and cartilage. pp189-196, Grune and Stratton, 1979.
 
14) Pilla AA : Electrochemical information transfer and its possible role in the control of cell function. Electrical properties of bone and cartilage. pp455-489, Grune and Stratton, 1979.
 
P.185 掲載の参考文献
1) Goodman R : Pulsing electromagnetic fields induce cellular transcription. Science 220 : 1283-1285, 1983.
PubMed
2) Takahashi K, Kaneko I, Date M, et al : Effect of pulsing electromagnetic fields on DNA synthesis in mammalian cells in culture. Experientia 42 : 185-186, 1985.
 
3) Cadossi R, Ceccherelli GB, Emilia G, et al : The effects of low frequency pulsing electromagnetic fields on the response of human lymphocytes to lectins. Bioelectrochemistry and Bioenergetics 19 : 315-322, 1988.
 
4) Goodman R, Wei L, Xu J, et al : Exposure of human cells to low-frequency electromagnetic fields results in quantitative changes in transcripts. Biochimica et Biophysica Acta 1009 : 216-220, 1989.
 
5) Petrini M, Polidori R, Ambrogi F, et al : Effets of different low-frequency electromagnetic fields on lymphocyte activation : at which cellular level? J Bioelectricity 9 : 159-166, 1990.
 
6) Rodan GA, Bourret LA, Norton LA : DNA synthesis in cartilage cells is stimulated by oscillating electric fields. Science 199 : 690-692, 1978.
PubMed
7) Cantini M, Cossarizza A, Bersani F, et al : Enhancing effect of low frequency pulsed electromagnetic fields on lectin-induced human lymphocyte proliferation. J Bioelectricity 5 : 91-104, 1986.
 
8) Cossarizza A, Monti D, Bersani f, et al : Extremely low frequency pulsed electromagnetic fields increase cell proliferation in lymphocytes from young and aged subjects. BBRC 160 : 692-698, 1989.
 
9) Kobayashi K, Sato K, Miyagi N, et al : Pulsing electromagnetic fields increase the proliferation of MG63 human osteosarcoma cells. Environmental Medicine 42 : 115-117, 1998.
 
10) 小林健二, 佐藤啓二, 岩田久, 他 : パルス電磁場刺激に対する骨肉腫細胞の変化-化学療法増強効果に関連して-. 日本生体電気刺激研究会誌 11 : 29-31, 1997.
 
11) 斉藤正敏, 澤田重之, 北本和督, 他 : PEMF刺激によるヒト骨肉腫細胞内カルシウム濃度の変化-in vitroでの検討-. 愛知医科大学紀要 40 (in press).
 
12) Smith GK, Cleary SF : Effects of pulsed electric fields on mouse spleen lymphocytes in vitro. Biochimica Biophysica Acta 763 : 325-331, 1983.
 
13) Goodman EM, Sharpe PT, Greenebaum B, et al : Pulsed magnetic fields alter the cell surface. FEBS 199 : 275-278, 1986.
PubMed
14) Omote Y, Hosokawa M, Komatsumoto M, et al : Treatment of experimental tumors with a combination of a pulsing magnetic fields and an antitumor drug. Jpn J Cancere Res 81 : 956-961, 1990.
 
15) Emilia G, Torelli G, Ceccherelli G, et al : Effect of low-frequenccy low-energy pulsing electromagnetic fields on the response to lectin stimulation of human normal and chronic ymphocytic leukemia lymphocytes. J Bioelectricity 4 : 145-161, 1985.
 
16) Walleczek J, Liburdy RP : Nonthermal 60Hz sinusoidal magnetic-field exposure enhances 45Ca2+ uptake in rat thymocytes : dependence on mitogen activation. FEBS 271 : 157-160, 1990.
 
17) Bawin SM, Adey WR, Sabbot IM : Ionic factors in release of 45Ca2＋ from chicken cerebral tissue by electromagnetic fields. Proc Natl Acad Sci 75 : 6314-6318, 1978.
PubMed
18) Blackman CF, Benane SG, House DE, et al : Effects of ELF and modulated RF fields on the efflux of calcium ions from brain tissue in vitro. Bioelectromagnetics 6 : 1-11, 1985.
PubMed
19) Conti P, Gigante GE, Cifone MG, et al : Effect of electromagnetic fields on two calcium dependent biological systems. J Bioelectricity 4 : 227-236, 1985.
 
20) Fitzsimmons RJ, Strong DD, Mohan S, et al : Low-amplitude, low-frequency electric fieldstimulated bone cell proliferation may in part be mediated by increased IGF-IIrelease. J Cellular Physiology 150 : 84-89, 1992.
PubMed
21) 宋淵, 佐藤啓二, 岩田久 : 骨肉腫細胞に対するシスプラチン化学療法効果を電磁場刺激によって増強させる試み. 日本生体電気刺激研究会誌 10 : 83-86, 1996.
 
22) Sollazzo V, Traina GC, DeMattei M, et al : Responses of human MG-63 osteosarcoma cell line and human osteoblast-like cells to pulsed electromagnetic fields. Bioelectromagnetics 18 : 541-547, 1997.
PubMed
23) 小林健二, 伊藤隆安, 韓斐, 他 : パルス電磁場刺激による骨肉腫細胞の浸潤能に対する影響. 日本生体電気刺激研究会誌 13 : 43-45, 1999.
 
24) De Mattei M, Caruso A, Traina GC, et al : Correlation between pulsed electromagnetic fields exposure time and cell proliferation increase in human osteosarcoma cell lines and human normal osteoblast cells in vitro. Bioelectromagnetics 20 : 177-182, 1999.
PubMed
25) Zhang D, Pan X, Ohno S, et al : No effects of pulsed electromagnetic fields on expression of cell adhesion molecules (Integrin, CD44) and matrix metalloproteinase-2/9 in osteosarcoma cell lines. Bioelectromagnetics 32 : 463-473, 2011.
PubMed
26) Pasquinelli P, Petrini M, Mattii L, et al : Biological effects of PEMF : An attempt to modigy cell resistance to anticancer agents. J Environmental Pathol Toxicol Oncol 12 : 193-197, 1993.
 
27) Hirata M, Kusuzaki K, Takeshita H, et al : Drug resistance modification using pulsing electromagnetic fields stimulation for multidrug resistant mouse osteosarcoma cell line. Anticancer Res 21 : 317-320, 2001.
PubMed
28) Miyagi N, Sato K, Rong Y, et al : Effects of PEMF on a murine osteosarcoma cell line : drug-resistant (P-glycoprotein-positive) and non-resistant cells. Bioelectromagnetics 21 : 112-121, 2000.
PubMed
29) 張大光, 大野秀一郎, 佐藤啓二, 他 : 血管内皮細胞に対する抗癌剤の効果をパルス電磁場刺激によって増強させる試み. 日本生体電気刺激研究会誌 17 : 15-19, 2003.
 
30) 大野秀一郎, 張大光, 大須賀友晃, 他 : 血管内皮細胞におけるパルス電磁場刺激の遺伝子的影響. 日本生体電気刺激研究会誌 18 : 23-27, 2004.
 
P.195 掲載の参考文献
1) Schmid GJ, Kobayashi C, Sandell LJ, et al : Fibroblast growth factor expression during skeletal fracture healing in mice. Dev Dyn 238 : 766-774, 2009.
PubMed
2) Zakrzewska M, Marcinkowska E, Wiedlocha A, et al : FGF-1 : from biology through engineering to potential medical applications. Crit Rev Clin Lab Sci 45 : 91-135, 2008.
PubMed
3) Towler DA : Vascular biology and bone format ion : hints from HIF. J Clin Invivest 117 : 1477-1480, 2007.
 
4) Mori S, Akagi M, Kikuyama A, et al : Axial shortening during distraction osteogenesis leads to enhanced bone formation in a rabbit model through the HIF-1 alpha/vasucular endothelial growth factor system. J Orthop Res 24 : 653-663, 2006.
 
5) Komatsu DE, Hadjiargyrou M : Activation of the transcription factor HIF-1 and its target genes, VEGF, HO-1, iNOS, during fracture repair. Bone 34 : 680-688, 2004.
PubMed
6) Azuma Y, Ito M, Harada Y, et al : Lowintensity pulsed ultrasound accelerates rat femoral fracture healing by acting on the various cellular reactions in the fracture callus. J Bone Miner Res 16 : 671-680, 2001.
PubMed
7) Sakurakichi K, Tsuchiya H, Uehara K, et al : Effect of timing of low-intensity pulsed ultrasound on distraction osteogenesis. J Orthop Res 22 : 395-403, 2004.
PubMed
8) Chan CW, Qin L, Lee KM, et al : Dosedependent effect of low-intensity pulsed ultrasound on callus formation during rapid distraction osteogenesis. J Orthop Res 24 : 2072-2079, 2006.
PubMed
9) Nolte PA, Klein-Nulend J, Albers GH, et al : Low-intensity ultrasound stimulates endochondral ossification in vitro. J Orthop Res 19 : 301-307, 2001.
 
10) Korstjens CM, Nolte PA, Burger EH, et al : Stimulation of bone cell differentiation by low-intensity ultrasound - a histomorphometric in vitro study. J Orthop Res 22 : 495-500, 2004.
PubMed
11) Naruse K, Mikuni-Takagaki Y, Urabe K, et al : Therapeutic ultrasound induced periosteal ossification without apparent changes in cartilage. Connect tissue res 50 : 55-63, 2009.
PubMed
12) Ogurtan Z, Celik I, Izci C, et al : Effect of experimental therapeutic ultrasound on the distal antebrachial growth plates in onemonth-old rabbits. Vet J 164 : 280-287, 2002.
 
13) Lyon R, Liu XC, Meier J, et al : The effect of therapeutic vs. high-intensity pulsed ultrasound on the rabbit growth plate. J Orthop Res 21 : 865-871, 2003.
 
14) Katano M, Naruse K, Uchida K, et al : Low intensity pulsed ultrasound accelerates delayed healing process by reducing the time required for the completion of endochondral ossification in the aged mouse femur fracture model. Exp Anim 60 : 385-395, 2011.
PubMed
15) Lu C, Miclau T, Hu D, et al : Cellular basis for age-related changes in fracture repair. J Orthop Res 23 : 1300-1307, 2005.
PubMed
16) Maes C, Carmeliet P, Moermans K, et al : Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Dev 111 : 61-73, 2002.
PubMed
17) Mayr-Wohlfart U, Waltenberger J, Hausser H, et al : Vascular endothelial growth factor stimulates chemotactic migration of primary human osteoblasts. Bone 30 : 472-477, 2002.
PubMed
18) Meyer RA Jr, Meyer MH, Tenholder M, et al : Gene expression in older rats with delayed union of femoral fractures. J Bone Joint Surg Am 85-A : 1243-1254, 2003.
PubMed
19) Meyer RA Jr, Tsahakis PJ, Martin DF, et al : Age and ovariectomy impair both the normalization of mechanical properties and the accretion of mineral by the fracture callus in rats. J Orthop Res 19 : 428-435, 2001.
 
20) Naruse K, Miyauchi A, Itoman M, et al : Distinct anabolic response of osteoblast to low-intensity pulsed ultrasound. J Bone Miner Res 18 : 360-369, 2003.
PubMed
21) Sherratt J : Chemotaxis and chemokinesis in eukaryotic cells : the Keller-Segel equations as an approximation to a detailed model. Bull Math Biol 56 : 129-146, 1994.
PubMed
P.202 掲載の参考文献
1) Young SR, Dyson M : Macrophage responsiveness to therapeutic ultrasound. Ultrasound Med Biol 16 : 809-816, 1990.
PubMed
2) Harvey W, Dyson M, Pond JB, et al : The stimulation of protein synthesis in human fibroblasts by therapeutic ultrasound. Rheumatol Rehabil 14 : 237, 1975.
PubMed
3) Ramirez A, Schwane JA, McFarland C, et al : The effect of ultrasound on collagen synthesis and fibroblast proliferation in vitro. Med Sci Sports Exerc 29 : 326-332, 1997.
PubMed
4) Byl N, McKenzie AL, West JM, et al : Lowdose ultrasound effects on wound healing : a controlled study in Yucatan pigs. Arch Phys Med Rehabil 73 : 656-664, 1992.
PubMed
5) Byl N, McKenzie AL, Wong T, et al : Incisional wound healing : a controlled study of low and high dose ultrasound. J Orthop Sports Phys Ther 18 : 619-628, 1993.
 
6) Andriacchi TP : Ligament ; injury and repair. Injury and Repair of the Musculoskeltal Soft Tissues, 1st ed, American Academy of Orthopaedic Surgeons, pp104-128, 1987.
 
7) 遠山晴一, 安田和則 : スポーツ医学のための基礎知識 靱帯の修復メカニズム. 整・災外 48 : 417-422, 2005.
 
8) Reher P, Doan N, Bradnock B, et al : Effect of ultrasound on the production of IL-8, basic FGF, and VEGF. Cytokine 11 : 416-423, 1999.
PubMed
9) Enwemeka CS, Rodriguez O, Mendosa S : The biomechanical effects of low-intensity ultrasound on healing tendons. Ultrasound Med Biol 16 : 801-807, 1990.
PubMed
10) 朝日盛也, 山本謙吾, 正岡利紀, 他 : アキレス腱損傷後の修復過程における低出力超音波の影響. 東医大誌 63 : 144-153, 2005.
 
11) 岩崎剛, 正岡利紀, 朝日盛也, 他 : 低出力超音波刺激によるアキレス腱損傷の治癒効果. 東医大誌 65 : 178-186, 2007.
Medical*Online
12) Takakura Y, Matsui N, Yoshiya S, et al : Low-intensity pulsed ultrasound enhances early healing of medial collateral ligament injuries in rats. J Ultrasound Med 21 : 283-288, 2002.
PubMed
13) Sparrow KJ, Finucane SD, Owen JR, et al : The effects of low-intensity ultrasound on medial collateral ligament healing in the rabbit model. Am J Sports Med 33 : 1048-1056, 2005.
PubMed
14) Warden SJ, Avin KG, Beck EM, et al : Lowintensity pulsed ultrasound accelerates and a nonsteroidal anti-inflammatory drug delays knee ligament healing. Am J Sports Med 34 : 1094-1102, 2006.
 
15) Fu SC, Shum WT, Hung LK, et al : Lowintensity pulsed ultrasound on tendon healing : a study of the effect of treatment duration and treatment initiation. Am J Sports Med 36 : 1742-1749, 2008.
PubMed
16) Benjamin M, Evans EJ, Copp L : The histology of tendon attachments to bone in man. J Anat 149 : 89-100, 1986.
 
17) Cooper RR, Misol S : Tendon and ligament insertion : a light and electron microscopic study. J Bone Joint Surg Am 52 : 1-21, 1970.
PubMed
18) Qin L, Lu H, Fok P, et al : Low-intensity pulsed ultrasound accelerates osteogenesis at bonetendon healing junction. Ultrasound Med Biol 32 : 1905-1911, 2006.
PubMed
19) Qin L, Fok P, Lu H, et al : Low intensity pulsed ultrasound increases the matrix hardness of the healing tissues at bone-tendon insertion-a partial patellectomy model in rabbits. Clin Biomech 21 : 387-394, 2006.
PubMed
20) Lu H, Qin L, Fok P, et al : Low-intensity pulsed ultrasound accelerates bone-tendon junction healing : a partial patellectomy model in rabbits. Am J Sports Med 34 : 1287-1296, 2006.
PubMed
21) Walsh WR, Stephens P, Vizesi F, et al : Effects of low-intensity pulsed ultrasound on tendonbone healing in an intra-articular sheep knee model. Arthroscopy 23 : 197-204, 2007.
 
22) Tsukada H, Ishibashi Y, Tsuda E, et al : The actual tendon-bone interface strength in a rabbit model. Arthroscopy 26 : 366-374, 2010.
 
23) 塚田晴彦 : 3. 骨折以外への応用 (3) 靱帯修復 (神宮司誠也編 : 骨折に対する低出力超音波パルス治療の基礎と臨床). pp95-103, メディカルレビュー社, 2008.
 
24) Kohno T, Ishibashi Y, Tsuda E, et al : Immunohistochemical demonstration of growth factors at the tendon-bone interface in anterior cruciate ligament reconstruction using a rabbit model. J Orthop Sci 12 : 67-73, 2007.
 
25) Lu H, Qin L, Cheung W, et al : Low-intensity pulsed ultrasound accelerated bone-tendon junction healing through regulation of vascular endothelial growth factor expression and cartilage formation. Ultrasound Med Biol 34 : 1248-1260, 2008.
PubMed
P.210 掲載の参考文献
1) Yoshimura N, Muraki S, Oka H, et al : Cohort profile : research on Osteoarthritis/Osteoporosis Against Disability study. Int J Epidemiol 39 : 988-995, 2010.
PubMed
2) Zhang W, Nuki G, Moskowitz RW, et al : OARSI recommendations for the management of hip and knee osteoarthritis : part III : Changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis Cartilage 18 : 476-499, 2010.
PubMed
3) Brosseau L, Yonge KA, Robinson V, et al : Thermotherapy for treatment of osteoarthritis. Cochrane Database Syst Rev 4 : CD004522, 2003.
PubMed
4) Lehmann JF, Masock AJ, Warren CG, et al : Effect of therapeutic temperatures on tendon extensibility. Arch Phys Med Rehabil 51 : 481-487, 1970.
PubMed
5) Lehmann JF, Brunner GD, Stow RW : Pain threshold measurements after therapeutic application of ultrasound, microwaves and infrared. Arch Phys Med Rehabil 39 : 560-565, 1958.
PubMed
6) Mense S : Effects of temperature on the discharges of muscle spindles and tendon organs. Pflugers Arch 374 : 159-166, 1978.
PubMed
7) Abramson DI, Bell Y, Tuck S, et al : Changes in blood flow, oxygen uptake and tissue temperatures produced by therapeutic physical agents. III. Effect of indirect or reflex vasodilsatation. Am J Phys Med 40 : 5-13, 1961.
PubMed
8) Denegar CR, Dougherty DR, Friedman JE, et al : Preferences for heat, cold, or contrast in patients with knee osteoarthritis affect treatment response. Clin Interv Aging 5 : 199-206, 2010.
PubMed
9) Hojo T, Fujioka M, Otsuka G, et al : Effect of heat stimulation on viability and proteoglycan metabolism of cultured chondrocytes : preliminary report. J Orthop Sci 8 : 396-399, 2003.
PubMed
10) Pelham HR : HSP70 accelerates the recovery of nucleolar morphology after heat shock. EMBO J 20 : 3095-3100, 1984.
 
11) Takahashi K, Kubo T, Kobayashi K, et al : Hydrostatic pressure influences mRNA expression of transforming growth factor-beta 1 and heat shock protein 70 in chondrocytelike cell line. J Orthop Res 15 : 150-158, 1997.
PubMed
12) Nakamura S, Arai Y, Takahashi KA, et al : Hydrostatic pressure induces apoptosis of chondrocytes cultured in alginate beads. J Orthop Res 24 : 733-739, 2006.
PubMed
13) Arai Y, Kubo T, Kobayashi K, et al : Adenovirus vector-mediated gene transduction to chondrocytes : in vitro evaluation of therapeutic efficacy of transforming growth factor-beta 1 and heat shock protein 70 gene transduction. J Rheumatol 24 : 1787-1795, 1997.
PubMed
14) Arai Y, Kubo T, Kobayashi K, et al : Control of delivered gene expression in chondrocytes using heat shock protein 70B promoter. J Rheumatol 26 : 1769-1774, 1999.
PubMed
15) Terauchi R, Takahashi KA, Arai Y, et al : Hsp70 prevents nitric oxide-induced apoptosis in articular chondrocytes. Arthritis Rheum 48 : 1562-1568, 2003.
PubMed
16) Kubo T, Towle CA, Mankin HJ, et al : Stressinduced proteins in chondrocytes from patients with osteoarthritis. Arthritis Rheum 28 : 1140-1145, 1985.
PubMed
17) Takahashi K, Kubo T, Arai Y, et al : Localization of heat shock protein in osteoarthritic cartilage. Scand J Rheumatol 26 : 368-375, 1997.
PubMed
18) Takahashi K, Kubo T, Goomer R. S, et al : Analysis of heat shock proteins and cytokines expressed during early stages of osteoarthritis in a mouse model. Osteoarthritis Cartilage 5 : 321-329, 1997.
 
19) Elo MA, Sironen RK, Kaarniranta K, et al : Differential regulation of stress proteins by high hydrostatic pressure, heat shock, and unbalanced calcium homeostasis in chondrocytic cells. J Cell Biochem 14 : 610-619, 2000.
 
20) Tonomura H, Takahashi KA, Mazda O, et al : Effects of heat stimulation via microwave applicator on cartilage matrix gene and HSP70 expression in the rabbit knee joint. J Orthop Res 26 : 34-41, 2008.
PubMed
21) Roediger WE : Decreased sulphur aminoacid intake in ulcerative colitis. Lancet 351 : 1555, 1998.
PubMed
22) Hayashi Y, Sawa Y, Fukuyama N, et al : Preoperative glutamine administration induces heat-shock protein 70 expression and attenuates cardiopulmonary bypass-induced inflammatory response by regulating nitric oxide synthase activity. Circulation 106 : 2601-2607, 2002.
PubMed
23) Tonomura H, Takahashi KA, Mazda O, et al : Glutamine protects articular chondrocytes from heat stress and NO-induced apoptosis with HSP70 expression. Osteoarthritis Cartilage 14 : 545-553, 2006.
PubMed
24) Hamiel CR, Pinto S, Hau A, et al : Glutamine enhances heat shock protein 70 expression via increased hexosamine biosynthetic pathway activity. Am J Physiol Cell Physiol 297 : C1509-1519, 2009.
PubMed
25) Zachara NE, O'Donnell N, Cheung WD, et al : Dynamic O-GlcNAc modification of nucleocytoplasmic proteins in response to stress. A survival response of mammalian cells. J Biol Chem 279 : 30133-30142, 2004.
 
26) Fujita S, Arai Y, Nakagawa S, et al : Combined microwave irradiation and intraarticular glutamine administration-induced HSP70 expression therapy prevents cartilage degradation in a rat osteoarthritis model. J Orthop Res 30 : 401-407, 2012.
 

臨床 生体電気・物理刺激による骨・軟部組織形成促進

P.219 掲載の参考文献
1) 赤居正美 : 電気刺激の骨形成効果-運動器疾患領域の臨床比較試験報告から-. 整形外科 50 : 446-451, 1999.
 
2) Akai M : Evidence-based medicine for orthopaedic practice. J Orthop Sci 7 : 731-742, 2002.
PubMed
3) Egger M, Smith GD, Altman DG (eds) : Systematic reviews in health care ; Metaanalysis in context. 2nd edition, BMJ Publishing Group, 2001.
 
4) Thacker SB : Meta-analysis ; a quantitative approach to research integration. JAMA 259 : 1685-1689, 1988.
PubMed
5) Cohen J : A power primer. Psychol Bull 112 : 155-159, 1992.
 
6) Moher D, Cook DJ, Eastwood S, et al : Improving the quality of reporting of meta-analyses of randomised controlled trials ; The QUOROM statement. Lancet 354, 1896-1900, 1999.
PubMed
7) Higgins JP, Thompson SG : Quantifying heterogeneity in a meta-analysis. Stat Med 21 : 1539-1558, 2002.
 
8) Akai M, Hayashi K : Effect of electrical stimulation on musculoskeletal systems ; a metaanalysis of controlled clinical trials. Bioelectromagnetics 23 : 132-143, 2002.
PubMed
9) Akai M, Kawashima N, Kimura T, et al : Electrical stimulation as an adjunct to spinal fusion : a meta-analysis of controlled clinical trials. Bioelectromagnetics 23 : 496-504, 2002.
PubMed
10) Hulme J, Robinson V, DeBie R, et al : Electromagnetic fields for the treatment of Osteoarthritis. Cochrane Database Syst Rev 1 : CD003523, 2002.
PubMed
11) Mollon B, da Silva V, Busse JW, et al : Electrical stimulation for long-bone fracturehealing : a meta-analysis of randomized controlled trials. J Bone Joint Surg Am 90 : 2322-2330, 2008.
PubMed
12) Goldstein C, Sprague S, Petrisor BA. Electrical stimulation for fracture healing ; current evidence. J Orthop Trauma 24 Supple 1 : S62-65, 2010.
 
13) Griffin XL, Costa ML, Parsons N, et al : Electromagnetic field stimulation for treating delayed union or non-union of long bone fractures in adults. Cochrane Database Syst Rev 4 : CD008471, 2011.
PubMed
14) Gam AN, Johannsen F : Ultrasound therapy for musculoskeletal disorders ; a meta-analysis. Pain 63 : 85-91, 1995.
PubMed
15) van der Windt DAWM, van der Heijden GJMG, van den Berg SGM, et al : Ultrasound therapy for musculoskeletal disorders ; a systematic review. Pain 81 : 257-271, 1999.
PubMed
16) Busse JW, Bhandari M, Kulkarni AV, et al : The effect of low-intensity pulsed ultrasound therapy on time to fracture healing : a metaanalysis. CMAJ 166 : 437-441, 2002.
 
17) Busse JW, Kaur J, Mollon B, et al : Low intensity pulsed ultrasonography for fractures : systematic review of randomised controlled trials. BMJ 338 : b351, 2009.
PubMed
18) Rutjes AW, Nuesch E, Sterchi R, et al : Therapeutic ultrasound for osteoarthritis of the knee or hip. Cochrane Database Syst Rev 1 : CD003132, 2010.
PubMed
19) Griffin XL, Smith N, Parsons N, et al : Ultrasound and shockwave therapy for acute fractures in adults. Cochrane Database Syst Rev 2 : CD008579, 2012.
PubMed
20) Beckerman H, de Bie RA, Bouter LM, et al : The efficacy of laser therapy for musculoskeletal and skin disorders ; a criteria-based meta-analysis of randomized clinical trials. Phys Ther 72 : 483-491, 1992.
PubMed
21) Gam AN, Thorsen H, Lonnberg F : The effect of low-level laser therapy on musculoskeletal pain ; a meta-analysis. Pain 52 : 63-66, 1993.
PubMed
22) Brosseau L, Welch V, Wells G, et al : Low level laser therapy for osteoarthritis and rheumatoid arthritis ; A metaanalysis. J Rheumatol 27 : 1961-1969, 2000.
PubMed
23) Lucas C, Stanborough RW, Freeman CL, et al : Efficacy of low-level laser therapy on wound healing in human subjects ; a systematic review. Lasers Med Sci 15 : 84-93, 2000.
 
24) Woodruff LD, Bounkeo JM, Brannon WM, et al : The efficacy of laser therapy in wound repair ; a meta-analysis of the literature. Photomed Laser Surg 22 : 240-247, 2004.
 
25) Enwemeka CS, Parker JC, Dowdy DS, et al : The efficacy of low-power lasers in tissue repair and pain control ; a meta-analysis study. Photomed Laser Surg 22 : 323-329, 2004.
PubMed
26) Chow RT, Barnsley L : Systematic review of the literature of low-level laser therapy (LLLT) in the management of neck pain. Lasers Surg Med 37 : 46-52, 2005.
PubMed
27) Chow RT, Johnson MI, Lopes-Martins RA, et al : Efficacy of low-level laser therapy in the management of neck pain ; a systematic review and meta-analysis of randomized placebo or active-treatment controlled trials. Lancet 374 : 1897-1908, 2009.
PubMed
28) 大森豊明監修 : 生体物理刺激と生体反応. フジ・テクノシステム, 2004.
 
29) 赤居正美 : 電気刺激の生体に及ぼす効果. 日整会誌 67 : 320-329, 1993.
Medical*Online
30) Pilla AA : Low-intensity electromagnetic and mechanical modulation of bone growth and repair : are they equivalent? J Orthop Sci 7 : 420-428, 2002.
PubMed
P.236 掲載の参考文献
1) 代田雅彦, 山田哲也, 関康弘, 他 : 上腕骨近位部骨折に対する骨電気刺激装置付き創外固定器の有用性について. 骨折 27 : 262-267, 2005.
 
2) 代田雅彦, 白川健, 小林正文 : 骨頭の外反嵌入・脱臼を伴う上腕骨近位部3-4 part 骨折に対するBGFの有用性. 骨折 29 : 473-478, 2007.
 
3) 亀山真 : 上腕骨近位端骨折に対する創外固定法. 関節外科 27 : 1356-1363, 2008.
Medical*Online
4) Boileau P, Krishnan SG, Tinsi L, et al : Tuberosity malposition and migration ; reasons for poor outcomes after hemiarthroplasty for displaced fractures of the proximal humerus. J Shoulder Elbow Surg 11 : 401-412, 2002.
PubMed
5) 佐藤克己 : 上腕骨近位部粉砕骨折に対する手術療法-人工骨頭置換術-. MB Orthop 17-4 : 59-64, 2004.
 
6) 湯川佳宣, 伏見昌樹, 水田隆之 : 電気・電磁場刺激による骨折治癒促進 (NEW MOOK整形外科 8). pp80-94, 金原出版, 2000.
 
7) 吉田隆司, 金郁吉, 久保俊一 : 電気刺激による骨折治療. Clin Calcium 19 : 101-109, 2009.
 
P.246 掲載の参考文献
1) 湯川佳宣, 水田隆之 : 交流電気刺激法, 直達式電気刺激による骨・軟部組織修復の促進, その基礎と応用. pp63-91, 文光堂, 1993.
 
2) 伊藤聰一郎, 久留水彩, 四宮謙一, 他 : 交流電気刺激装置による橈骨遠位端骨折治療の適応と問題点. 日本生体電気刺激研究会誌 17 : 35-37, 2003.
 
3) 保田岩夫 : 骨折治療に関する基礎的諸問題. 京都医会誌 4 : 395-406, 1953.
 
4) Yasuda I : Fundamental aspects of fracture treatment. Clin Orthop 124 : 5-8, 1977.
 
5) 湯川佳宣, 鈴木博之, 伏見昌樹, 他 : 保存治療の見直しと新しい治療法-外傷性脛骨偽関節に対する微弱電気刺激法の効果-, 骨折 9 : 15-21, 1997.
 
6) Orbay JL, Touhami A : Current concepts in volar fixed-angle fixation of unstable distal radius fractures. Clin Orthop Relat Res 445 : 58-67, 2006.
PubMed
7) Mehling I, Meier M, Schlor U, et al : Multidirectional palmar fixed-angle plate fixation for unstable distal radius fracture. Handchir Mikrochir Plast Chir 39 : 29-33, 2007.
PubMed
8) Rogachefsky RA, Lipson SR, Applegate B, et al : Treatment of severely comminuted intraarticular fractures of the distal end of the radius by open reduction and combined internal and external fixation. J Bone Joint Surg Am 83 : 509-519, 2001.
PubMed
9) 有薗行朋, 浜田良機 : 掌側ロッキングプレートとbridging型創外固定器の併用によるdie-punch fragmentを含むTypeC3橈骨遠位端骨折の治療成績. 日手会誌 28 : 305-308, 2012.
 
10) Bodamyali T, Kanczler JM, Simon B, et al : Effect of faradic products on direct currentstimulated calvarial organ culture calcium levels. Biochem Biophys Res Commun 264 : 657-661, 1999.
PubMed
11) Steinbeck MJ, Kim JK, Trudeau MJ, et al : Involvement of hydrogen peroxide in the differentiation of clonal HD-11EM cells into osteoclast-like cells. J Cell Physiol 176 : 574-587, 1998.
 
12) Cho M, Hunt TK, Hussain MZ : Hydrogen peroxide stimulates macrophage vascular endothelial growth factor release. Am J Physiol Heart Circ Physiol 280 : 2357-2363, 2001.
 
P.251 掲載の参考文献
1) Pritchett JW : Statin therapy decreases the risk of ION in patients receiving steroids. Clin Orthop Relat Res 386 : 173-178, 2001.
 
2) Cui Q, Wang GJ, Su CC, et al : The Otto Aufranc Award. Lovastatin prevents steroid induced adipogenesis and ION. Clin Orthop Relat Res 344 : 8-19, 1997.
 
3) Motomura G, Yamamoto T, Miyanishi K, et al : Combined effects of an anticoagulant and a lipid-lowering agent on the prevention of steroid-induced ION in rabbits. Arthritis Rheum 50 : 3387-3391, 2004.
 
4) Nagasawa K, Tada Y, Koarada S, et al : Prevention of steroid-induced ION of femoral head in systemic lupus erythematosus by anti-coagulant. Lupus 15 : 354-357, 2006.
 
5) Kuribayashi M, Fujioka M, Takahashi KA, et al : Vitamin E prevents steroid-induced osteonecrosis in rabbits. Acta Orthop 81 : 154-160, 2010.
PubMed
6) Goto T, Fujioka M, Ishida M, et al : Noninvasive up-regulation of angiopoietin-2 and fibroblast growth factor-2 in bone marrow by pulsed electromagnetic field therapy. J Orthop Sci 15 : 661-665, 2010.
PubMed
7) Roland D, Ferder M, Kothuru R, et al : Effects of pulsed magnetic energy on a microsurgically transferred vessel. Plast Reconstr Surg 105 : 1371-1374, 2000.
PubMed
8) Tepper OM, Callaghan MJ, Chang EI, et al : Electromagnetic fields increase in vitro and in vivo angiogenesis through endothelial release of FGF-2. FASEB J 18 : 1231-1233, 2004.
PubMed
9) Yamamoto T, Irisa T, Sugioka Y, et al : Effects of pulse methylprednisolone on bone and marrow tissues : corticosteroid-induced ION in rabbits. Arthritis Rheum 40 : 2055-2064, 1997.
 
10) Miyanishi K, Yamamoto T, Irisa T, et al : Bone marrow fat cell enlargement and a rise in intraosseous pressure in steroid-treated rabbits with ION. Bone 30 : 185-190, 2002.
 
11) Bassett CA : Fundamental and practical aspects of therapeutic uses of pulsed electromagnetic fields (PEMFs). Crit Rev Biomed Eng 17 : 451-529, 1989.
PubMed
12) Kabata T, Kubo T, Matsumoto T, et al : Apoptotic cell death in steroid induced ION : an experimental study in rabbits. J Rheumatol 27 : 2166-2171, 2000.
 
13) Fujita M, Shirai K : A comparative study of the therapeutic effect of probucol and pravastatin on xanthelasma. J Dermatol 23 : 598-602, 1996.
PubMed
14) Wang GJ, Sweet DE, Reger SI, et al : Fat-cell changes as a mechanism of avascular necrosis of the femoral head in cortisone-treated rabbits. J Bone Joint Surg Am 59 : 729-735, 1977.
PubMed
15) Shaw SL, Salmon ED, Quatrano RS : Digital photography for the light microscope : results with a gated, video-rate CCD camera and NIH-image software. Biotechniques 19 : 946-955, 1995.
 
16) Smith TL, Wong-Gibbons D, Maultsby J : Microcirculatory effects of pulsed electromagnetic fields. J Orthop Res 22 : 80-84, 2004.
PubMed
17) Massari L, Fini M, Cadossi R, et al : Biophysical stimulation with pulsed electromagnetic fields in ION of the femoral head. J Bone Joint Surg Am 88 : 56-60, 2006.
 
18) Bassett CA, Schink-Ascani M, Lewis SM : Effects of pulsed electromagnetic fields on Steinberg ratings of femoral head ION. Clin Orthop Relat Res 246 : 172-185, 1989.
 
19) Steinberg ME, Brighton CT, Steinberg DR, et al : Treatment of avascular necrosis of the femoral head by a combination of bone grafting, decompression, and electrical stimulation. Clin Orthop Relat Res 186 : 137-153, 1984.
PubMed
20) Steinberg ME, Brighton CT, Bands RE, et al : Capacitive coupling as an adjunctive treatment for avascular necrosis. Clin Orthop Relat Res 261 : 11-18, 1990.
PubMed
21) Steinberg ME, Brighton CT, Corces A, et al : ION of the femoral head. Results of core decompression and grafting with and without electrical stimulation. Clin Orthop Relat Res 249 : 199-208, 1989.
 
22) Kabata T, Kubo T, Matsumoto T, et al : Onset of steroid-induced ION in rabbits and its relationship to hyperlipaemia and increased free fatty acids. Rheumatology (Oxford) 21 : 2166-2171, 2005.
 
23) Carmeliet P : VEGF gene therapy : stimulating angiogenesis or angioma-genesis? Nat Med 6 : 1102-1103, 2000.
 
24) Lee RJ, Springer ML, Blanco-Bose WE, et al : VEGF gene delivery to myocardium : deleterious effects of unregulated expression. Circulation 102 : 898-901, 2000.
PubMed
25) Nakamura F, Fujioka M, Takahashi KA, et al : Evaluation of the hemodynamics of the femoral head compared with the ilium, femoral neck and femoral intertrochanteric region in healthy adults : measurement with positron emission tomography (PET). Ann Nucl Med 19 : 549-555, 2005.
 
26) Yang C, Yang S, Du J, et al : Vascular endothelial growth factor gene transfection to enhance the repair of avascular necrosis of the femoral head of rabbit. Chin Med J (Engl) 116 : 1544-1548, 2003.
 
27) Akai M, Hayashi K : Effect of electrical stimulation on musculoskeletal systems ; a meta-analysis of controlled clinical trials. Bioelectromagnetics 23 : 132-143, 2002.
PubMed
28) Ishida M, Fujioka M, Takahashi KA, et al : Electromagnetic fields : a novel prophylaxis for steroid-induced osteonecrosis. Clin Orthop Relat Res 466 : 1068-1073, 2008.
PubMed
29) Kanno S, Oda N, Abe M, et al : Establishment of a simple and practical procedure applicable to therapeutic angiogenesis. Circulation 99 : 2682-2687, 1999.
PubMed
P.258 掲載の参考文献
1) Cebrian JL, Gallego P, Frances A, et al : Comparative study of the use of electromagnetic fields in patients with pseudoarthrosis of tibia treated by intramedullary nailing. Int Orthop 34 : 437-440, 2010.
PubMed
2) Aaron RK, Ciombor DMcK, Simon BJ : Treatment of nonunions with electric and electromagnetic fields. Clin Orthop 419 : 21-29, 2004.
 
3) Aaron RK, Ciombor DMcK, Simon BJ : Stimulation of growth factor synthesis by electric and electromagnetic fields. Clin Orthop 419 : 30-37, 2004.
 
4) Bassett CAL, Valdes MG, Hernandez E : Modification of fracture repair with selected pulsing electromagnetic fields. J Bone Joint Surg 64-A : 888-895, 1982.
 
5) Bassett CAL, Mitchell SN, Gaston SR : Treatment of ununited tibial diaphyseal fractures with pulsing electromagnetic fields. J Bone Joint Surg 63-A : 511-523, 1981.
 
6) Brighton C, Shaman P, Heppenstall B : Tibial nonunion treated with direct current ; capacitive coupling or bone graft. Clin Orthop 321 : 223-234, 1995.
PubMed
7) Brighton CT, Pollack SR : Treatment of nonunion of the tibia with a capacitively coupled electrical field. J Trauma 24 : 153-155, 1984.
 
8) Brighton CT : Treatment of nonunion of the tibia with constant direct current. J Trauma 21 : 189-195, 1981.
 
9) Brighton CT, Pollack SR : Treatment of recalcitrant nonunion of the tibia with capacitively coupled electric field. J Bone Joint Surg 67-A : 577-585, 1985.
 
10) Friendemberg ZB, Brighton CT : Bioelectric potentials in bone. J Bone Joint Surg 48-A : 915-923, 1996.
 
11) Heckman JD, et al : Nonunion treatment with pulsed electromagnetic fields. Clin Orthop 161 : 58-66, 1981.
PubMed
12) Heppenstall RB, Brighton CT, Esterhai JL Jr, et al : Prognostic factors in nonunion of the tibia : an evaluation of 185 cases treated with constant direct current. J Trauma 24 : 790-795, 1984.
 
13) Lavine LS, Grodzinsky AJ : Electrical Stimulation of repairs of bone. J Bone Joint Surg 69-A : 626, 1987.
 
14) Simonis RB, Parnell EJ, Ray PS, et al : Electrical treatment of tibial non-union : a prospective, randomised, double-blind trial. Injury 34 : 357-362, 2003.
 
15) 伊藤博元 : 電磁場刺激法 (Pulsing Electromagnetic Fields ; PEMFs) による難治性骨折の治療. MB orthop 6 : 61-67, 1993.
 
16) 井上望 : 骨折治癒促進効果 電気・電磁場刺激. THE BONE 18 : 719-724, 2004.
Medical*Online
17) 八代忍, 松村崇史, 相羽整, 他 : 難治性骨折に対する超音波治療と電気刺激治療との比較. 整形外科 52 : 337-342, 2001.
 
18) 安田和則 : 序文. OS NOW instruction 20, 2011.
 
19) Matsushita T, Watanabe Y : Chipping and lengthening technique for delayed unions and nonunions with shortening or bone loss. J Orthop Trauma 21 : 404-406, 2007.
PubMed
20) 野坂光司, 木村善明, 宮腰尚久, 他 : 骨癒合不全に対する電気刺激治療と超音波治療の併用効果. 別冊整形外科 61 : 65-68, 2012.
 
21) 遠藤直人, 高橋栄明 : 電気刺激での骨組織の変化. 骨・関節・靱帯 3 : 323-331, 1990.
 
22) 関康弘, 代田雅彦 : 上腕骨近位部および橈骨遠位端骨折に対する骨交流電気刺激法の経験. 骨折 27 : 27-31, 2005.
Medical*Online
23) 井上望 : 骨折治癒促進効果 電気・電磁場刺激. THE BONE 18 : 719-724, 2004.
Medical*Online
P.263 掲載の参考文献
1) Duarte LR : The stimulation of bone growth by ultrasound. Arch Orthop Trauma Surg 101 : 153-159, 1983.
PubMed
2) Heckman JD, Ryaby JP, McCabe J, et al : Acceleration of tibial fracture-healing by non-invasive, low-intensity pulsed ultrasound. J Bone Joint Surg 76A : 26-34, 1994.
 
3) Kristiansen TK, Ryaby JP, McCabe J, et al : Accelerated healing of distal radial fractures with the use of specific, low-intensity ultrasound. J Bone Joint Surg 79A : 961-973, 1997.
 
4) Rutten S, Nolte PA, Guit GK, et al : Use of low-intensity pulsed ultrasound fot posttraumatic nonunions of tibia ; a review of patients treated in the Netherlands. J Trauma 62 : 902-908, 2007.
 
5) Gebauer D, Mayr E, Orthner E, et al : Lowintensity pulsed ultrasound ; effects on nonunions. Ultrasound Med Biol 31 : 1391-1402, 2005.
PubMed
6) Nolte PA, van der Krans A, Patka P, et al : Low-intensity pulsed ultrasound in the treatment of nonunions. J Trauma 51 : 693-703, 2001.
PubMed
7) 角田雅也, 水野耕作 : 骨折の超音波治療. 整形・災害外科 41 : 243-247, 1998.
 
8) 水野耕作, 山野慶樹, 糸満盛憲, 他 : 超音波骨折治療器の遷延癒合・偽関節に対する多施設臨床試験. 整形・災害外科 46 : 757-765, 2003.
 
9) Mayr E, Frankel V, Ruter A : Ultrasound - an alternative healing method for nonunions? Arch Orthop Trauma Surg 120 : 1-8, 2000.
PubMed
10) 新井通浩, 竹中信行, 芳野晃, 他 : 難治性骨折に対する低出力超音波パルス (LIPUS) の治療成績とターゲティングの工夫. 骨折 27 : 21-26, 2005.
 
11) 白井利明, 竹内良平, 荒武正人, 他 : 骨折および骨切り術後の遷延癒合に対するLIPUS治療による治療成績. 骨折 29 : 163-167, 2007.
Medical*Online
12) 小川健, 石井朝夫, 平野篤, 他 : 多施設での低出力超音波パルス使用状況調査-効果と骨癒合不良因子の検討-. 東日本整災外雑誌 19 : 123-128, 2007.
 
13) Jingushi S, Mizuno K, Matsushita T, et al : Low-intensity pulsed ultrasound treatment for post-oparative delayed union or nonunion of long bone fractures. J Orthop Sci 12 : 35-41, 2007.
PubMed
P.273 掲載の参考文献
1) 上野竜一, 藤村幸毅, 朝貝芳美 : ペルテス病10年以上経過例の検討. 東日本臨床整形外科学会誌 8 : 259-262, 1996.
 
2) Herring JA, Kim HT, Browne R : Legg-Calve-Perthes disease. Part II : prospective multicenter study of effect of treatment on outcome. J Bone Joint Surg Am 86 : 2121-2134, 2004.
PubMed
3) 金郁吉 : Perthes病の診断・治療・予後. 整形外科 63 : 473-481, 2012.
 
4) Asagai Y, Watanabe Y, Yamamoto K : Application of infrared irradiation theapy to Perthes disease. Laser Therapy 15 : 105-113, 2006.
 
5) Arita H, Hanaoka K : Linear polarized nearinfrared ray therapy equipment. Pain clinic 19 : 49-56, 1998.
 
6) Asagai Y, Yamamoto K, Ohshiro T : Significance of near-infrared irradiation in the treatment of Perthes disease. Laser Therapy 17 : 83-94, 2008.
 
7) 朝貝芳美, 山本謙吾 : ペルテス病に対する近赤外線治療成績不良例の検討. 日小整会誌 20 : 26-30, 2011.
Medical*Online
8) Asagai Y, Kanai H, Miura Y, et al : Application of low reactive-level laser therapy (LLLT) in the functional training of cerebral palsy patients. Laser Therapy 6 : 195-201, 1994.
 
9) 朝貝芳美 : 先天性股関節脱臼に対する低出力レーザー照射の意義-臼蓋と大腿骨頭への影響-. 日小整会誌 19 : 10-15, 2010.
Medical*Online
10) Asagai Y, Yamamoto K, Ohshiro T, et al : Bone metabolism incerebral palsy and the effect of light-emitting diode (LED) irradiation. Laser Therapy 21 1 : 23-31, 2012.
PubMed
P.280 掲載の参考文献
1) Ikeda K, Yokoyama M, Okada K, et al : Longterm follow-up of the vascularized iliac bone graft. Microsurgery 18 : 419-423, 1998.
PubMed
2) Kabata T, Tsuchiya H, Sakurakichi K, et al : Reconstruction with distraction osteogenesis for juxta-articular nonunions with bone loss. J Trauma 58 : 1213-1222, 2005.
PubMed
3) 池田和夫, 田尻和八, 中谷聡, 他 : 体外衝撃波骨形成誘導 (ESW Induced Boneformation ; ESWIB) に関する基礎的研究. 医用電子と生体工学 31 : 28, 1993.
 
4) 桑原正明 : 結石破砕への応用 (高山和喜編 : 衝撃波ハンドブック). pp928-938, シュプリンガー・フェアラーク東京, 1995.
 
5) 池田和夫, 田尻和八, 中谷聡, 他 : 体外衝撃波による骨形成誘導について (高山和喜編 : 衝撃波ハンドブック). pp944-947, シュプリンガー・フェアラーク東京, 1995.
 
6) 池田和夫, 富田勝郎, 高山和喜 : 体外衝撃波を整形外科領域へ応用するために-その基礎的研究-. 整形外科 49 : 1565-1571, 1998.
 
7) 池田和夫, 富田勝郎, 高山和喜 : 体外衝撃波骨形成誘導法の偽関節治療への応用. 整形外科 50 : 1497-1501, 1999.
 
8) Ikeda K, Tomita K, Takayama K : Application of extracorporeal shock wave on bone. J Trauma 47 : 946-950, 1999.
 
9) Valchanou VD, Michailov P : High energy shock waves in the treatment of delayed and nonunion of fractures. International Orthopaedics 15 : 181-184, 1991.
PubMed
10) Haupt G, Haupt A, Ekkernkamp A, et al : Influence of shock waves on fracture healing. Urology 39 : 529-532, 1992.
PubMed
11) Schleberger R, Senge T : Non-invasive treatment of long-bone pseudoarthrosis by shock waves. Arch Orthop Trauma Surg 111 : 224-227, 1992.
PubMed
12) 西須孝 : 骨・関節疾患に対するextracorporeal shock-wave therapy (体外衝撃波療法). 整・災外 45 : 747-750, 1998.
 
13) 池田和夫, 富田勝郎, 高山和喜 : 体外衝撃波による骨癒合促進の試み. 骨折 20 : 705-708, 1998.
Medical*Online
14) Vogel J, Hopf C, Eysel P, et al : Application of extracorporeal shock-waves in the treatment of pseudoarthrosis of the lower extremity. Arch Orthop Trauma Surg 116 : 480-483, 1997.
PubMed
15) Biedermann R, Martin A, Handle G, et al : Extracorporeal shock waves in the treatment of nonunions. J Trauma 54 : 936-942, 2003.
PubMed
16) Wang CJ, Chen HS, Chen CE, et al : Tretment of nonunions of long bone fractures with shock waves. Clin Orthop Relat Res 387 : 95-101, 2001.
 
17) 尾上英俊, 木村一雄, 山口哲, 他 : 偽関節に対する体外衝撃波治療. 骨折 29 : 824-827, 2007.
Medical*Online
18) 杉岡佳織, 落合信康, 見目智紀, 他 : 上腕骨近位端骨折および骨幹部骨折偽関節に対して体外衝撃波治療を行った2例. 肩関節 35 : 1025-1028, 2011.
 
19) Kearney CJ, Lee JY, Padera RF, et al : Extracorporeal shock wave-induced proliferation of periosteal cells. J Orthop Res 29 : 1536-1543, 2011.
 
20) Hausdorf J, Sievers B, Schmitt-Sody M, et al : Stimulation of bone growth factor synthesis in human osteoblasts and fibroblasts after extracorporeal shock wave application. Arch Orthop Trauma Surg 131 : 303-309, 2011.
PubMed
21) 池田和夫 : 体外衝撃波による骨折の治療. Clinical Calcium 19 : 718-725, 2009.
 
P.289 掲載の参考文献
1) Valchanou VD, Michailov P : High energy shock waves in the treatment of delayed and nonunion of fractures. Int Orthop 15 : 181-184, 1991.
PubMed
2) Loew M, Jurgowski W, Mau HC, et al : Treatment of calcifying tendinitis of rotator cuff by extracorporeal shock waves : a preliminary report. J Shoulder Elbow Surg 4 : 101-106, 1995.
PubMed
3) Rompe JD, Hopf C, Kullmer K, et al : Low-energy extracorporal shock wave therapy for persistent tennis elbow. Int Orthop 20 : 23-27, 1996.
PubMed
4) Rompe JD, Hopf C, Nafe B, et al : Low-energy extracorporeal shock wave therapy for painful heel : a prospective controlled singleblind study. Arch Orthop Trauma Surg 115 : 75-79, 1996.
 
5) Narasaki K, Shimizu H, Beppu M, et al : Effect of extracorporeal shock waves on callus formation during bone lengthening. J Orthop Sci 8 : 474-481, 2003.
PubMed
6) Saisu T, Takahashi K, Kamegaya M, et al : Effects of extracorporeal shock waves on immature rabbit femurs. J Pediatr Orthop B 13 : 176-183, 2004.
PubMed
7) Takahashi K, Yamazaki M, Saisu T, et al : Gene expression for extracellular matrix proteins in shockwave-induced osteogenesis in rats. Calcif Tissue Int 74 : 187-193, 2004.
PubMed
8) Ikeda K, Tomita K, Takayama K : Application of extracorporeal shock wave on bone : preliminary report. J Trauma 47 : 946-950, 1999.
 
9) Wang FS, Yang KD, Kuo YR, et al : Temporal and spatial expression of bone morphogenetic proteins in extracorporeal shock wavepromoted healing of segmental defect. Bone 32 : 387-396, 2003.
PubMed
10) Chen YJ, Wurtz T, Wang CJ, et al : Recruitment of mesenchymal stem cells and expression of TGF-beta 1 and VEGF in the early stage of shock wave-promoted bone regeneration of segmental defect in rats. J Orthop Res 22 : 526-534, 2004.
PubMed
11) Saisu T, Kamegaya M, Wada Y, et al : Acetabular augmentation induced by extracorporeal shock waves in rabbits. J Pediatr Orthop B 14 : 162-167, 2005.
PubMed
12) 西須孝, 守屋秀繁, 亀ヶ谷真琴, 他 : 体外衝撃波の骨関節発育に及ぼす影響. 日本小児整形外科学会雑誌 6 : 123-127, 1996.
 
13) Ohtori S, Inoue G, Mannoji C, et al : Shock wave application to rat skin induces degeneration and reinnervation of sensory nerve fibres. Neurosci Lett 315 : 57-60, 2001.
PubMed
14) 三橋繁, 西須孝, 高橋謙二 : 体外衝撃波を用いた新しい脊髄損傷モデルの作製. 日神経救急研会誌 13 : 50-53, 2000.
 
15) Chen YJ, Wang CJ, Yang KD, et al : Extracorporeal shock waves promote healing of collagenase-induced Achilles tendinitis and increase TGF-beta1 and IGF-I expression. J Orthop Res 22 : 854-861, 2004.
PubMed
16) Vetrano M, d'Alessandro F, Torrisi MR, et al : Extracorporeal shock wave therapy promotes cell proliferation and collagen synthesis of primary cultured human tenocytes. Knee Surg Sports Traumatol Arthrosc 19 : 2159-2168, 2011.
 
17) Wang CJ, Wang FS, Yang KD, et al : Shock wave therapy induces neovascularization at the tendon-bone junction. A study in rabbits. J Orthop Res 21 : 984-989, 2003.
PubMed
18) Rompe JD, Kirkpatrick CJ, Kullmer K, et al : Dose-related effects of shock waves on rabbit tendo Achillis : a sonographic and histological study. J Bone Joint Surg Br 80-B : 546-552, 1998.
PubMed
19) Nishida T, Shimokawa H, Oi K, et al : Extracorporeal cardiac shock wave therapy markedly ameliorates ischemia-induced myocardial dysfunction in pigs in vivo. Circulation 110 : 3055-3061, 2004.
PubMed
20) Stojadinovic A, Elster EA, Anam K, et al : Angiogenic response to extracorporeal shock wave treatment in murine skin isografts. Angiogenesis 11 : 369-380, 2008.
PubMed
21) Murata R, Nakagawa K, Ohtori S, et al : The effects of radial shock waves on gene transfer in rabbit chondrocytes in vitro. Osteoarthritis Cartilage 15 : 1275-1282, 2007.
PubMed
22) Xu ZH, Jiang Q, Chen DY, et al : Extracorporeal shock wave treatment in nonunions of long bone fractures. Int Orthop 33 : 789-793, 2009.
PubMed
23) Schaden W, Fischer A, Sailler A : Extracorporeal shock wave therapy of nonunion or delayed osseous union. Clin Orthop Relat Res 387 : 90-94, 2001.
PubMed
24) 落合信靖, 見目智紀, 山崎博範, 他 : 肩慢性石灰性腱炎に対する体外衝撃波療法の有効性. 肩関節 35 : 579-582, 2011.
 
25) Wang CJ, Chen HS : Shock wave therapy for patients with lateral epicondylitis of the elbow : a one- to two-year follow-up study. Am J Sports Med 30 : 422-425, 2002.
PubMed
26) Haake M, Konig IR, Decker T, et al : Extracorporeal shock wave therapy in the treatment of lateral epicondylitis : a randomized multicenter trial. J Bone Joint Surg Am 84 : 1982-1991, 2002.
PubMed
27) 落合信靖, 西須孝 : 上腕骨外側上顆炎に対する体外衝撃波療法の短期成績. 日肘会誌 17 : 7-9, 2010.
 
28) 落合信靖, 国吉一樹, 西須 孝 : 上腕骨内側上顆炎に対する体外衝撃波治療の短期成績. 日肘会誌 18 : 67-69, 2011.
 
29) Kudo P, Dainty K, Clarfield M, et al : Randomized, placebo-controlled, doubleblind clinical trial evaluating the treatment of plantar fasciitis with an extracoporeal shockwave therapy (ESWT) device : a North American confirmatory study. J Orthop Res 24 : 115-123, 2006.
PubMed
30) Rasmussen S, Christensen M, Mathiesen I, et al : Shockwave therapy for chronic Achilles tendinopathy : a double-blind, randomized clinical trial of efficacy. Acta Orthop 79 : 249-256, 2008.
PubMed
31) Vulpiani MC, Vetrano M, Savoia V, et al : Jumper's knee treatment with extracorporeal shock wave therapy : a long-term follow-up observational study. J Sports Med Phys Fitness 47 : 323-328, 2007.
 

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