難治性肝疾患の診療を極める

出版社: 文光堂
著者:
発行日: 2014-05-18
分野: 臨床医学:内科  >  肝/胆/膵
ISBN: 9784830618932
電子書籍版: 2014-05-18 (第1版第2刷)
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難治性肝疾患の診療に役立つ基礎研究分野から臨床エビデンスに至る最先端の知見を網羅したテキスト.

目次

  • 難治性肝疾患の診療を極める

    ―目次―

    自己免疫性肝疾患編
    ?.基本編 〜自己免疫性肝疾患を診る前の基礎知識〜
     1.肝と免疫システム
      A.自然免疫と獲得免疫
      B.肝構成細胞と免疫
     2.自己免疫性肝疾患と自己抗体
     3.自己免疫性肝疾患の発症機序
      A.AIHの発症機序
      B.PBCの発症機序
      C.PSCの発症機序
     4.自己免疫性肝疾患の疫学
      A.AIHの疫学
      B.PBCの疫学
      C.PSCの疫学
     5.自己免疫性肝疾患と原発性肝癌
    II.診断編
     1.自己免疫性肝疾患の病理診断
     2.自己免疫性肝疾患の診断
      A.AIHの診断
      B.PBCの診断
      C.PSCの診断
     3.自己免疫性肝疾患非定型例の診断
     4.小児のAIHとPSCの診断
     Debate IgG4関連AIHは存在するか
     Lecture 核抗体陽性NASHとAIHとの鑑別
     LectureIgG4関連硬化性胆管炎とPSC鑑別のポイント
    III.治療編
     1.自己免疫性肝疾患の薬物療法
      A.AIHの治療
      B.PBCの治療
      C.PSCの治療
     2.自己免疫性肝疾患に対する肝移植の現状
     3.小児AIHとPSCの治療
     Debate AIHはウルソデオキシコール酸単独治療で
         コントロール可能か
     Lecture ステロイド抵抗AIH例の対応について
     Lecture AIH様病態を伴ったPBCの治療について
    IV.自己免疫性肝疾患を理解するための基礎研究
     1.自己免疫性肝炎の動物モデル
     2.自己免疫性肝疾患と遺伝子解析
     3.自己免疫性肝炎とケモカイン・サイトカイン
     4.AIHの新規自己抗体

    薬物性肝障害編
    ?.基本編 〜薬物性肝障害を診る前の基礎知識〜
     1.薬物性肝障害の実態と疫学
     2.薬物性肝障害の発生機序
     Lecture 健康食品による肝障害
     Lecture 薬物性肝内胆管消失症候群
    II.診断編
     1.薬物性肝障害の診断
     2.薬物性肝障害の病理
    III.治療編
     1.薬物性肝障害の治療
    IV.薬物性肝障害を理解するための基礎研究
     1.薬物性肝障害の危険因子
     2.薬物起因性自己免疫性肝炎

    急性肝不全編
    ?.基本編 〜急性肝不全を診る前の基礎知識〜
     1.急性肝不全と類縁疾患の概念
     2.わが国における劇症肝炎・LOHFの実態(2009年以前)
     3.わが国における急性肝不全の実態(2011年以降)
     4.de novo B型肝炎の病態と対策
    II.診断編
     1.急性肝不全の成因の診断
     2.急性肝不全の劇症化予知
     3.劇症肝炎・LOHFの予後予測および肝移植ガイドライン2008
    III.治療編
     1.急性肝不全の治療ストラテジー
     2.急性肝不全の人工肝補助療法
     3.急性肝不全に対する肝移植
     Debate on-line HDFは急性肝不全の標準的治療法となり得るか?
    IV.急性肝不全を理解するための基礎研究
     1.劇症肝炎の発症機序 ?アポトーシス・細胞死
     2.劇症肝炎の発症機序 ?微小循環障害
     3.劇症肝炎の発症機序 ?再生不全
     4.急性肝不全に対する肝再生医療:HGFによる肝再生医療
     5.急性肝不全に対する骨髄細胞を用いた肝再生医療の現状
     Frontier 予後予測のデータマイニング

    その他の肝疾患編
    肝内結石症
    ?.基本編 〜肝内結石症を診る前の基礎知識〜
     1.肝内結石症の定義と病型
     2.肝内結石症の成因と病態
     3.肝内結石症の疫学
    II.診断編
     1.肝内結石症の診断
     2.肝内結石症からの発癌
    III.治療編
     1.肝内結石症の内科的治療
     2.肝内結石症の外科的治療
    IV.肝内結石症を理解するための基礎研究
     1.胆管癌の新規バイオマーカー
     2.胆汁の遺伝子発現解析の試み

    門脈血行異常症
    ?.基本編 〜門脈血行異常症を診る前の基礎知識〜
     1.特発性門脈圧亢進症
     2.肝外門脈閉塞症とBudd-Chiari症候群
     3.門脈血栓症
     4.肝細静脈閉塞症
    II.診断編
     1.門脈圧亢進症の画像診断
    III.治療編
     1.門脈圧亢進症に対する内科的治療(IVR治療)
     2.門脈圧亢進症に対する腹腔鏡下脾摘術と
        胃上部血行遮断兼脾摘術(Hassab術)
    IV.門脈血行異常症を理解するための基礎研究
     1.門脈圧亢進症とサイトカイン

    金属代謝異常による肝疾患
     1.ヘモクロマトーシス
     2.ウィルソン病

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[ 自己免疫性肝疾患編 ]

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[ 薬物性肝障害編 ]

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[ 急性肝不全編 ]

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[ その他の肝疾患編 ]

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