わかりやすい核医学

出版社： 文光堂
著者：
発行日： 2016-01-15
分野： 臨床医学：一般  >  放射線/核医学
ISBN： 9784830637452
電子書籍版： 2016-01-15 （第1版第1刷）
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難しくなりがちな核医学を，病態生理から検査の進め方，画像の読み方へと解説を進めることにより，誰にでも理解しやすい構成とした．また，典型例の美しい画像の数々に加え，最新のトピックスや，専門医がしっておきたい知識もNOTEとして別枠に掲載し，基礎から最新の話題までを網羅した内容となっている．放射線科専門医をめざす若手医師はもちろん，核医学検査，内用療法が必要な診療領域の医師・技師すべてを対象とした，みんなのための核医学のテキスト．

目次

  • わかりやすい核医学

    ―目次―

    I 核医学で知っておくべき最低限の基礎知識
    　A 放射能・放射線の基礎
    　B 放射性医薬品
    　C 核医学装置
    　D 画像解析

    II 脳神経
    　病態生理
    　検査の進め方
    　画像の読み方

    III 循環器
    　A 心筋血流シンチグラフィ
    　B 心臓交感神経イメージング
    　C 心臓脂肪酸代謝
    　D 心臓糖代謝イメージング
    　E 心プールシンチグラフィ

    IV 呼吸器
    　病態生理
    　検査の進め方
    　画像の読み方

    V 内分泌
    　A 甲状腺
    　B 副甲状腺
    　C 副腎

    VI 骨
    　病態生理
    　検査の進め方
    　画像の読み方

    VII 消化器
    　A 唾液腺
    　B 肝臓
    　C 胆道
    　D 消化管出血

    VIII 腎・泌尿器
    　病態生理
    　検査の進め方
    　画像の読み方

    IX 腫　瘍
    　A 基礎
    　B 生理的集積
    　C 脳
    　D 頭頸部
    　E 胸部
    　F 腹部
    　G 生殖器
    　H その他の癌

    X 炎　症
    　炎症・腫瘍シンチグラフィ
    　67Gaシンチグラフィによる炎症病変の評価
    　18F-FDG PET／CTにおける炎症病変の評価
    　67Gaシンチグラフィと18F-FDG PET／CTの比較

    XI センチネルリンパ節
    　病態生理
    　検査法の概説
    　検査の進め方・画像の読み方

    XII 内用療法
    　総論
    　甲状腺癌に対する131I内用療法
    　Basedow病に対する131I内用療法
    　神経内分泌腫瘍に対する131I-MIBG治療
    　骨転移に対する89SrCl2治療
    　悪性リンパ腫に対する90Y標識抗CD20モノクローナル抗体治療

    XIII　核医学の今後の発展
    　装置の改良
    　解析法の進歩
    　放射性薬剤の開発
    　新しい臨床応用

この書籍の参考文献

参考文献のリンクは、リンク先の都合等により正しく表示されない場合がありますので、あらかじめご了承下さい。

本参考文献は電子書籍掲載内容を元にしております。

I 核医学で知っておくべき最低限の基礎知識

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II 脳神経

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5) Morioka T et al : Cerebrospinal fluid leakage in intracranial hypotension syndrome : usefulness of indirect findings in radionuclide cisternography for detection and treatment monitoring. Clin Nucl Med 33 (3) : 181-185, 2008
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III 循環器

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P.75 掲載の参考文献
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2) Jacobson AF et al : Myocardial iodine-123 meta-iodobenzylguanidine imaging and cardiac events in heart failure. Results of the prospective ADMIREHF (AdreView Myocardial Imaging for Risk Evaluation in Heart Failure) study. J Am Coll Cardiol 55 (20) : 2212-2221, 2010
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4) Inaba Y et al : Diagnostic accuracy of beta-methyl-para- [123I] -iodophenyl-pentadecanoic acid (BMIPP) imaging. A meta analysis. J Nucl Cardiol 15 (3) : 345-352, 2008
 
5) Kawai Y et al : Significance of reduced uptake of iodinated fatty acid analoque for the evaluation of patients with acute chest pain. J Am Coll Cardiol 38 (7) : 1888-1894, 2001
 
6) Nishimura M et al : Myocardial scintigraphy using a fatty acid analogue detects coronary artery disease in hemodialysis patients. Kidney Int 66 (2) : 811-845, 2004
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8) Tadamura E et al : Impairment of BMIPP uptake precedes abnormalities in oxygen and glucose metabolism in hypertrophic cardiomyopathy. J Nucl Med 39 (3) : 390-396, 1998
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P.86 掲載の参考文献
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2) Ishida Y et al : Recommendations for (18) F-fluorodeoxyglucose positron emission tomography imaging for cardiac sarcoidosis : Japanese Society of Nuclear Cardiology recommendations. Ann Nucl Med 28 (4) : 393-403, 2014
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IV 呼吸器

P.109 掲載の参考文献
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2) 本田憲業ほか : 呼吸器, 肺の解剖と生理・肺血流シンチグラフィ/放射性ガスによる肺換気・血流シンチグラフィ/エロソール肺吸入シンチグラフィ. 最新臨床核医学, 改訂第3版, 利波紀久ほか (編), 金原出版, 1999, 288-325
 
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V 内分泌

P.116 掲載の参考文献
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VI 骨

P.152 掲載の参考文献
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VII 消化器

P.158 掲載の参考文献
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VIII 腎・泌尿器

P.188 掲載の参考文献
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10) Edefonti A et al : Febrile urinary tract infection : Clinical laboratory diagnosis, imaging, and prognosis. Semin Nucl Med 44 (2) : 123-128, 2014
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IX 腫瘍

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3) Nomori H et al : Fluorine 18-taggedfluorodeoxyglucose positron emission tomographic scanning to predict lymph node metastasis, invasiveness, or both, in clinical T1N0M0 lung adenocarcinoma. J Thorac Cardiovasc Surg 128 (3) : 396-401, 2004
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4) Naruke T et al : Lymph node sampling in lung cancer : how should it be done? Eur J Cardiothorac Surg 16 (Suppl 1) : S17-24, 1999
 
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6) Cerfolio RJ et al : When is it best to repeat a 2-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography scan on patients with non-small cell lung cancer who have received neoadjuvant chemoradiotherapy? Ann Thorac Surg 84 (4) : 1092-1097, 2007
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9) Flores RM : The role of PET in the surgical management of malignant pleural mesothelioma. Lung Cancer 49 (Suppl 1) : S27-32, 2005
 
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11) Otsuka H : The utility of FDG-PET in the diagnosis of thymic epithelial tumors. J Med Invest 59 (3-4) : 225-234, 2012
 
12) Beaulieu S et al : Positron emission tomography of schwannomas : emphasizing its potential in preoperative planning. Am J Roentgenol 182 (4) : 971-974, 2004
 
13) Ezuddin S et al : MIBG and FDG PET findngs in a patient with malignant pheochromocytoma : a significant discrepancy. Clin Nucl Med 30 (8) : 579-581, 2005
 
14) Sharma P et al : Diagnostic accuracy of integrated (18) F-FDG PET/CT for restaging patients with malignant germ cell tumours. Br J Radiol 87 (1040) : 20140263, 2014
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15) Cho A et al : The additional value of attenuation correction CT acquired during 18F-FDG PET/CT in differentiating mature from immature teratomas. Clin Nucl Med 39 (3) : e193-196, 2014
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16) 日本食道学会 (編) : 食道癌取扱い規約 第10版補訂版, 金原出版, 2008
 
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18) van Vliet EP et al : Staging investigations for oesophageal cancer : a meta-analysis. Br J Cancer 98 (3) : 547-557, 2008
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19) Chatterton BE et al : Positron emission tomography changes management and prognostic stratification in patients with oesophageal cancer : results of a multicentre prospective study. Eur J Nucl Med Mol Imaging 36 (3) : 354-361, 2009
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20) Gillies RS et al : Additional benefit of 18F-fluorodeoxyglucose integrated positron emission tomography/computed tomography in the staging of oesophageal cancer. Eur Radiol 21 (2) : 274-280, 2011
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21) Ngamruengphong S et al : Assessment of response to neoadjuvant therapy in esophageal cancer : an updated systematic review of diagnostic accuracy of endoscopic ultrasonography and fluorodeoxyglucose positron emission tomography. Dis Esophagus 23 (3) : 216-231, 2010
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23) Jadvar H et al : 18F-FDG uptake in lung, breast, and colon cancers : molecular biology correlates and disease characterization. J Nucl Med 50 (11) : 1820-1827, 2009
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24) Cooper KL et al : Positron emission tomography (PET) for assessment of axillary lymph node status in early breast cancer : A systematic review and meta-analysis. Eur J Surg Oncol 37 (3) : 187-198, 2011
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25) Eubank WB et al : Impact of FDG PET on defining the extent of disease and on the treatment of patients with recurrent or metastatic breast cancer. AJR Am J Roentgenol 183 (2) : 479-486, 2004
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26) Aukema TS et al : The role of FDG PET/CT in patients with locoregional breast cancer recurrence : a comparison to conventional imaging techniques. Eur J Surg Oncol 36 (4) : 387-392, 2010
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P.245 掲載の参考文献
1) 日本胃癌学会 (編) : 胃癌取扱い規約 第14版, 金原出版, 2010
 
2) Yamada A et al : Evaluation of 2-deoxy-2- [18F] fluoro-D-glucose positron emission tomography in gastric carcinoma : relation to histological subtypes, depth of tumor invasion, and glucose transporter-1 expression. Ann Nucl Med 20 (9) : 597-604, 2006
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3) Nakamoto Y et al : Clinical value of whole-body FDG-PET for recurrent gastric cancer : a multicenter study. Jpn J Clin Oncol 39 (5) : 297-302, 2009
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4) Ott K et al : Prediction of response to preoperative chemotherapy in gastric carcinoma by metabolic imaging : results of a prospective trial. J Clin Oncol 21 (24) : 4604-4610, 2003
 
5) 日本肝癌研究会 (編) : 原発性肝癌取扱い規約 第5版補訂版, 金原出版, 2009
 
6) Torizuka T et al : In vivo assessment of glucose metabolism in hepatocellular carcinoma with FDGPET. J Nucl Med 36 (10) : 1811-1817, 1995
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7) Hatano E et al : Preoperative positron emission tomography with fluorine-18-fluorodeoxyglucose is predictive of prognosis in patients with hepatocellular carcinoma after resection. World J Surg 30 (9) : 1736-1741, 2006
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8) Kong YH et al : Positron emission tomography with fluorine-18-fluorodeoxyglucose is useful for predicting the prognosis of patients with hepatocellular carcinoma. Korean J Hepatol 10 (4) : 279-287, 2004
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9) Ho CL et al : Dual-tracer PET/CT imaging in evaluation of metastatic hepatocellular carcinoma. J Nucl Med 48 (6) : 902-909, 2007
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10) Anderson CD et al : Fluorodeoxyglucose PET imaging in the evaluation of gallbladder carcinoma and cholangiocarcinoma. J Gastrointest Surg 8 (1) : 90-97, 2004
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11) Koh T et al : Differential diagnosis of gallbladder cancer using positron emission tomography with fluorine-18-labeled fluoro-deoxyglucose (FDGPET). J Surg Oncol 84 (2) : 74-81, 2003
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12) Kitajima K et al : Clinical impact of whole body FDG-PET for recurrent biliary cancer : a multicenter study. Ann Nucl Med 23 (8) : 709-715, 2009
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13) Kluge R et al : Positron emission tomography with [(18)F] fluoro-2-deoxy-D-glucose for diagnosis and staging of bile duct cancer. Hepatology 33 (5) : 1029-1035, 2001
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14) Petrowsky H et al : Impact of integrated positron emission tomography and computed tomography on staging and management of gallbladder cancer and cholangiocarcinoma. J Hepatol 45 (1) : 43-50, 2006
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15) 日本膵臓学会 (編) : 膵癌取扱い規約 第6版補訂版, 金原出版, 2013
 
16) Asagi A et al : Utility of contrast-enhanced FDGPET/CT in the clinical management of pancreatic cancer : impact on diagnosis, staging, evaluation of treatment response, and detection of recurrence. Pancreas 42 (1) : 11-19, 2013
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17) Wang XY et al : The value of 18F-FDG positron emission tomography/computed tomography on the pre-operative staging and the management of patients with pancreatic carcinoma. Hepatogastroenterology 61 (135) : 2102-2109, 2014
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18) Hamidian Jahromi A et al : Accuracy of multi-detector computed tomography, fluorodeoxyglucose positron emission tomography-CT, and CA 19-9 levels in detecting recurrent pancreatic adenocar cinoma. JOP 14 (4) : 466-468, 2013
 
19) 日本泌尿器科学会ほか (編) : 膀胱癌取扱い規約 第3版, 金原出版, 2001
 
20) Fuccio C et al : Restaging clear cell renal carcinoma with 18F-FDG PET/CT. Clin Nucl Med 39 (6) : e320-324, 2014
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21) van Hoeij FB et al : Incidental colonic focal FDG uptake on PET/CT : can the maximum standardized uptake value (SUVmax) guide us in the timing of colonoscopy? Eur J Nucl Med Mol Imaging 42 (1) : 66-71, 2015
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22) Maffione AM et al : Diagnostic accuracy and impact on management of (18) F-FDG PET and PET/CT in colorectal liver metastasis : a meta-analysis and systematic review. Eur J Nucl Med Mol Imaging 42 (1) : 152-163, 2015
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23) Akhurst T et al : Recent chemotherapy reduces the sensitivity of [18F] fluorodeoxyglucose positron emission tomography in the detection of colorectal metastases. J Clin Oncol 23 (34) : 8713-8716, 2005
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24) Ozkan E et al : The role of 18F-FDG PET/CT in detecting colorectal cancer recurrence in patients with elevated CEA levels. Nucl Med Commun 33 (4) : 395-402, 2012
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1) 日本泌尿器科学会ほか (編) : 前立腺癌取扱い規約 第4版, 金原出版, 2010
 
2) Chang CH et al : Detecting metastatic pelvic lymph nodes by 18F 2 deoxyglucose positron emission tomography in patients with prostate specific antigen relapse after treatment for localized prostate cancer. Urol Int 70 (4) : 311-315, 2003
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3) Schoder H et al : 2 [18F] fluoro 2 deoxyglucose positron emission tomography for the detection of disease in patients with prostatic specific antigen relapse after radical prostatectomy. Clin Cancer Res 11 (13) : 4761-4769, 2005
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4) Liu Y : Diagnostic role of fluorodeoxyglucose positron emission tomography computed tomography in prostate cancer. Oncol Lett 7 (6) : 2013-2018, 2014
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5) Jadvar H : Imaging Evaluation of Prostate Cancer with 18F-fluorodeoxyglucose PET/CT : Utility and Limitations. Eur J Nucl Med Mol Imaging 40 (Suppl 1) : S5-10, 2013
 
6) Lee ST et al : PET in Prostate and Bladder Tumors. Semin Nucl Med 42 (4) : 231-246, 2012
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7) 日本産科婦人科学会ほか (編) : 子宮体癌取扱い規約 第3版, 金原出版, 2012
 
8) Lee SI et al : Evaluation of Gynecologic Cancer with MR Imaging, 18F-FDG PET/CT, and PET/MR Imaging. J Nucl Med 56 (3) : 436-443, 2015
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11) 日本産科婦人科学会ほか (編) : 子宮頸癌取扱い規約 第3版, 金原出版, 2012
 
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13) 日本産科婦人科学会ほか (編) : 卵巣腫瘍取扱い規約 第1部 第2版, 金原出版, 2009
 
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P.262 掲載の参考文献
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2) Pakos EE et al : 18F-FDG PET for evaluation of bone marrow infiltration in staging of lymphoma : a meta-analysis. J Nucl Med 46 (6) : 958-963, 2005
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3) Engert A et al : Reduced-intensity chemotherapy and PET-guided radiotherapy in patients with advanced stage Hodgkin's lymphoma (HD15 trial) : a randomised, open-label, phase 3 non-inferiority trial. Lancet 379 (9828) : 1791-1799, 2012
 
4) Cerci JJ et al : 18F-FDG PET after 2 cycles of ABVD predicts event-free survival in early and advanced Hodgkin lymphoma. J Nucl Med 51 (9) : 1337-1343, 2010
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5) Mikhaeel NG et al : 18-FDG-PET for the assessment of residual masses on CT following treatment of lymphomas. Ann Oncol 11 (Suppl 1) : 147-150, 2000
 
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7) Pregno P et al : Interim 18-FDG-PET/CT failed to predict the outcome in diffuse large B-cell lymphoma patients treated at the diagnosis with rituximab-CHOP. Blood 119 (9) : 2066-2073, 2012
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X 炎症

P.273 掲載の参考文献
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2) 日本サルコイドーシス/肉芽腫性疾患学会 診断基準改訂委員会 : サルコイドーシスの診断基準と診断の手引き-2006. 日サ会誌 27 (1) : 89-102, 2007
 
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4) Zhang J et al : Characterizing IgG4-related disease with 18F-FDG PET/CT : a prospective cohort study. Eur J Nucl Med Mol Imaging 41 (8) : 1624-1634, 2014
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5) Yang J et al : PET Index of Bone Glucose Metabolism (PIBGM) Classification of PET/CT Data for Fever of Unknown Origin Diagnosis. PLoS One 10 6) : e0130173, 2015
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6) Balink H et al : 18F-FDG PET/CT in inflammation of unknown origin : a cost-effectiveness pilot-study. Eur J Nucl Med Mol Imaging 42 (9) : 1408-1413, 2015
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XI センチネルリンパ節

P.279 掲載の参考文献
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4) Clarke M et al : Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival : an overview of the randomised trials. Lancet 366 (9503) : 2087-2106, 2005
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5) Krag DN et al : Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer : overall survival findings from the NSABP B-32 randomised phase 3 trial. Lancet 11 (10) : 927-933, 2010
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6) 日本皮膚科学会ほか (編) : 科学的根拠に基づく皮膚悪性腫瘍診療ガイドライン 第2版, 金原出版, 2015
 
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XII 内用療法

P.294 掲載の参考文献
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2) 日本核医学学会 : 患者の核医学診療施設の入退出に係る安全確保に関するガイドライン, 2014
 
3) 日本核医学会分科会 腫瘍・免疫核医学研究会「放射性ヨード内用療法」委員会 (編) : バセドウ病の放射性ヨード内用療法に関するガイドライン, 2005
 
4) 日本核医学学会 : 131I-MIBG内照射療法の適正使用ガイドライン案改定, 2014
 
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10) Hoskin P et al : Efficacy and safety of radium-223 dichloride in patients with castration-resistant prostate cancer and symptomatic bone metastases, with or without previous docetaxel use : a prespecified subgroup analysis from the randomised, double-blind, phase 3 ALSYMPCA trial. Lancet Oncol 15 (12) : 1397-1406, 2014
 
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12) Valachis A et al : High versus low radioiodine activity in patients with differentiated thyroid cancer : a meta-analysis. Acta Oncol 52 (6) : 1055-1061, 2013
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13) Yoshinaga K et al : Effects and safety of Imetaiodobenzylguanidine (MIBG) radiotherapy in malignant neuroendocrine tumors : Results from a multicenter observational registry. Endocr J 61 (12) : 1171-1180, 2014
 
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XIII 核医学の今後の発展

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2) Shiga T et al : A new PET scanner with semiconductor detectors enables better identification of intratumoral inhomogeneity. J Nucl Med 50 (1) : 158-155, 2009
 

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