腸内フローラと難病・自己免疫疾患

出版社: 医薬出版
著者:
発行日: 2015-10-20
分野: 基礎医学  >  医動物(寄生虫)
ISBN: 9784990673932
電子書籍版: 2015-10-20 (初版第1刷)
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目次

  • 表紙
  • 目次
  • はじめに
  • 特別講演1. 腸内細菌とリウマチ性疾患
  • 要約
  • 1. はじめに
  • 2. 腸内フローラと関節炎
  • 3. 関節リウマチの臨床・免疫病理
  • 4. 腸内細菌感作による実験的関節炎
  • 5. 関節リウマチの病因・病態 - 特に腸内細菌との関連
  • 1) 関節リウマチの腸内細菌共通抗体
  • 2) 関節リウマチにおける自然免疫の関与
  • 3) HLAと腸内細菌との分子相同性
  • 4) 関節リウマチの亜群 ( rheumatoid arthritis subgroup )
  • 5) 関節リウマチと腸内フローラの構成変化 ( dysbiosis )
  • 6) DysbiosisからみたRA subgroupの発生機序
  • 6. 関節リウマチの原因療法を目指して - dysbiosisの改善
  • 1) 絶食療法
  • 2) プロバイオティクスによる治療
  • 7. まとめ
  • 謝辞
  • 文献
  • 質疑応答
  • 特別講演2. 粘膜バリアにおける免疫システム - 腸内細菌のクロストーク
  • 要約
  • 1. 序論
  • 2. 獲得免疫機構と腸内細菌
  • 3. 免疫グロブリン ( Ig ) A
  • 4. IgA多様化制御 : GC T細胞の役割
  • 5. 結論
  • 文献
  • 質疑応答
  • 講演1. 腸内細菌叢と関節破壊
  • 要約
  • 1. 無菌マウス
  • 2. Toll様受容体 ( TLRs ) と関節炎
  • 3. マウスにおけるTLR4アンタゴニストとヒト化関節炎モデル
  • 4. 歯周炎併発による関節炎の増悪化
  • 文献
  • 質疑応答
  • 講演2. 腸内細菌と1型糖尿病
  • 要約
  • 1. 序論
  • 2. 腸内細菌は自己免疫疾患の誘導因子にも抑制因子にもなり得る
  • 3. 腸内細菌叢の影響は同じ個体でも器官により異なる可能性がある
  • 4. 腸内細菌叢はどのようにTIDの進行に影響を及ぼすのか ?
  • 5. どのような細胞種がMyD88欠損マウスのTIDを防ぐのか ?
  • 6. MyD88が存在しない場合におけるTIDの抑制に重要なシグナル経路について
  • 7. 腸内細菌叢に関連してTIDに影響を及ぼす他の因子について
  • 文献
  • 質疑応答
  • 講演3 腸内フローラと炎症性腸疾患
  • 要約
  • 1. はじめに
  • 2. マウス腸管における自然免疫系細胞の解析
  • 3. ヒト腸管における自然免疫系細胞の解析
  • 4. ヒト腸管より単離したHLA - DRhighLin - CD14 + CDI63low細胞
  • 5. おわりに
  • 文献
  • 質疑応答
  • 講演4. 腸内細菌叢と多発性硬化症
  • 1. はじめに
  • 2. MSの病態とT細胞
  • 3. 動物モデルの解析
  • 4. 今後の展望
  • 文献
  • 質疑応答
  • 講演5. 炎症関連大腸がんモデルにおける大腸粘膜付随細菌叢の破綻
  • 要約
  • 1. 序論
  • 2. 炎症と発がん
  • 3. サイトカインシグナルと炎症関連大腸発がん
  • 4. CACの発症過程におけるIL6 trans - signalingを介したIL6 / Stat3路の重要性
  • 5. 腸内細菌叢と大腸発がん
  • 6. IL6 trans - signalingの生成と腸内細菌
  • 7. 大腸粘膜付随細菌叢の特性について
  • 8. おわりに
  • 文献
  • 質疑応答
  • 総合討論
  • SUMMARY : Intestinal Microbiota, Intractable disease and Autoimmunity
  • 奥付

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特別講演1. 腸内細菌とリウマチ性疾患

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特別講演2. 粘膜バリアにおける免疫システム - 腸内細菌のクロストーク

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講演1. 腸内細菌叢と関節破壊

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講演2. 腸内細菌と1型糖尿病

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講演3 腸内フローラと炎症性腸疾患

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講演4. 腸内細菌叢と多発性硬化症

P.65 掲載の参考文献
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講演5. 炎症関連大腸がんモデルにおける大腸粘膜付随細菌叢の破綻

P.73 掲載の参考文献
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