テーラーメイド個人対応栄養学

出版社： 建帛社
著者：
発行日： 2009-05-20
分野： 臨床医学：一般  >  栄養/食事/輸血
ISBN： 9784767961408
電子書籍版： 2009-05-20 （初版）
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個人の栄養・代謝状態と疾病リスクを総合的に判定するためのポストゲノム科学の応用を論述。個人対応型の栄養相談につながる「個人対応栄養学」を先駆ける基礎・臨床的研究の成果を分かりやすく説明する。

目次

  • 表紙
  • 序文
  • 目次
  • 序章 個人対応栄養学の潮流
  • 1. 栄養問題の変遷
  • 2. 食事の個別性
  • 3. 健康状態の定量化
  • 4. 個別化栄養アセスメント
  • 5. 個人代謝プロファイル法の戦略
  • 第1編 個人対応栄養学の原理と技術
  • 第1章 人類遺伝学から見た個人対応栄養学の基盤
  • 1. ゲノムの個体差
  • 2. 食塩感受性遺伝子
  • 3. 倹約遺伝子
  • 4. ゲノム研究の進展と糖尿病感受性遺伝子の同定
  • 5. まとめ
  • 第2章 ニュートリゲノミクスのヒトへの応用戦略
  • 1. ニュートリゲノミクスの二つのアプローチ
  • (1) メカニズムの解析手法としてのニュートリゲノミクス
  • (2) バイオマーカーのプロファイリング情報源としてのニュートリゲノミクス
  • 2. 人間栄養学におけるニュートリゲノミクスの意義
  • (1) 現代における人間栄養学の課題
  • (2) 人間栄養学研究へのニュートリゲノミクスの応用
  • 3. 末梢血白血球における糖代謝関連バイオマーカーの探索
  • (1) 期待される血糖関連指標
  • (2) 動物モデルにおける高血糖誘導による末梢血白血球トランスクリプトームの変化
  • (3) 糖負荷試験による末梢血白血球トランスクリプトームの短期の変化
  • (4) 2型糖尿病モデル (OLETF) の発症過程における末梢血白血球トランスクリプトームの変化
  • (5) 食事誘発性インスリン抵抗性モデルラットにおける末梢血白血球トランスクリプトームの変化
  • 4. 臨床研究における代謝性疾患リスクバイオマーカーの妥当性の検証
  • (1) 2型糖尿病患者における末梢血白血球遺伝子発現の変化
  • (2) 内臓脂肪の評価とメタボリックシンドローム関連指標との関連
  • (3) 健診受診者における血液候補バイオマーカーとメタボリックシンドローム関連指標との関連性
  • 第3章 プロテオミクスによる生活習慣病リスクバイオマーカーの探索
  • 1. はじめに
  • 2. 酸化特異的翻訳後修飾タンパク質と生活習慣病
  • 3. 血清タンパク質プロファイル
  • 4. おわりに
  • 第4章 抗体チップによる未病診断・食品機能性評価の新しい展開
  • 1. はじめに
  • 2. 「タンパクチップ」への期待
  • 3. 「酸化ストレスバイオマーカー」の開発
  • 4. 「抗体チップ」評価法の確立
  • 第5章 個人対応栄養指標確立に向けたメタボリックプロファイリング法の重要性と可能性
  • 1. はじめに
  • 2. メタボローム解析技術のバイオサイエンスへの応用
  • 3. メタボローム測定法
  • 4. メタボローム研究の方向性
  • 5. メタボローム解析の応用例
  • (1) 網羅的メタボローム測定
  • (2) 選択的メタボローム測定
  • (3) 個別分析
  • 6. 問題点と今後の課題
  • 第2編 個人対応栄養学の応用と実践
  • 第6章 成人病胎児期発症 (起源) 説 ―成人病の素因が胎生期に形成される機序―
  • 1. はじめに
  • 2. 出生体重と成人病発症リスク
  • 3. 胎内低栄養での成人病素因の形成機序
  • (1) 解剖学的変化
  • (2) 遺伝子発現制御系の変化
  • 4. DNAメチル化から見た疾病素因の形成
  • (1) 受精, 着床時の栄養が及ぼす影響
  • (2) 胎仔期・胎児期の低栄養と葉酸
  • (3) スキンシップと中枢の機能変化 (出生直後の臨界期)
  • (4) エピジェネティックスとメチル基代謝
  • 5. 最後に
  • 第7章 葉酸代謝関連遺伝子多型に基づくテーラーメイド栄養の実践
  • 1. 葉酸とホモシステイン代謝
  • 2. 葉酸代謝関連遺伝子多型
  • 3. 葉酸不足と認知症
  • 4. 葉酸摂取の効果
  • 5. ゲノム対応栄養指導
  • 6. さかど葉酸プロジェクト
  • (1) さかど葉酸プロジェクト概要
  • (2) 食と認知症予防講習会
  • (3) 遺伝子多型に応じたテーラーメイド栄養指導の実践と効果
  • (4) 葉酸添加食品による集団アプローチ
  • 第8章 骨粗鬆症とテーラーメイド栄養学
  • 1. はじめに
  • 2. 性ホルモン関連遺伝子
  • 3. インスリン様成長因子 (IGF-1) 遺伝子
  • 4. ミオスタチン遺伝子
  • 5. ビタミンD受容体 (VDR) 遺伝子
  • 6. LDL受容体関連タンパク5 (LRP5) 遺伝子
  • 7. 他の遺伝子
  • 終章 個人対応栄養学の展望
  • 1. 栄養アセスメントの技術革新へ向けて
  • 2. 日本人におけるエビデンスデータベース構築の必要性
  • 3. 個人に対応した食品選択の基盤
  • 4. 機能性食品成分に対する応答性の個人差
  • 5. 保健機能食品におけるレギュラトリーサイエンスの活用
  • 索引
  • 責任編集者 / 執筆者
  • 奥付

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序章 個人対応栄養学の潮流

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第1編 個人対応栄養学の原理と技術

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第2章 ニュートリゲノミクスのヒトへの応用戦略

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第4章 抗体チップによる未病診断・食品機能性評価の新しい展開

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第5章 個人対応栄養指標確立に向けたメタボリックプロファイリング法の重要性と可能性

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第2編 個人対応栄養学の応用と実践

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第7章 葉酸代謝関連遺伝子多型に基づくテーラーメイド栄養の実践

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第8章 骨粗鬆症とテーラーメイド栄養学

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終章 個人対応栄養学の展望

P.192 掲載の参考文献
1) Hara K., Boutin P., Mori Y. et al.:Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 2002; 51; 536-340.
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2) Goda T.:COE Health-promotion project. Proceedings of the Tenth Shizuoka Forum on Health and Longevity, 2006, p100-105.
 

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