日本臨牀　76/増刊7　老年医学（下）

出版社： 日本臨牀社
発行日： 2018-08-31
分野： 臨床医学：一般  >  雑誌
ISSN： 00471852
雑誌名：
特集： 老年医学（下）―基礎・臨床研究の最新動向―
電子書籍版： 2018-08-31 （初版第1刷）
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目次

  • IX　高齢者の精神疾患
    　１．老年精神医学における研究と臨床の課題
    　２．認知症
    　３．うつ病
    　４．アパシー
    　５．不安症/不安障害
    　６．高齢者におけるパーソナリティ障害
    　７．高齢者の身体症状症
    　8．セルフ・ネグレクト
    　9．統合失調症および他の精神病性障害
    　10．依存

    X　高齢者の生活習慣病
    　１．高血圧
    　２．糖尿病
    　３．脂質異常症
    　４．肥満症
    　５．高齢者の生活習慣修正

    XI　高齢者の臓器別疾患
    　１．皮膚疾患
    　２．眼疾患
    　３．耳鼻咽喉疾患
    　４．歯科・口腔疾患
    　５．呼吸器疾患
    　６．循環器疾患
    　７．消化器疾患
    　８．腎疾患
    　９．婦人科疾患　
    　10．泌尿器疾患
    　11．整形外科疾患
    　12．免疫疾患
    　13．神経疾患
    　14．感染症
    　15．内分泌疾患
    　16．血液疾患

    XII　高齢者の手術
    　１．老年医学的な術前評価の有用性
    　２．周術期管理
    　３．高齢者の麻酔

    XIII　高齢者の救急医療
    　１．高齢者の救急医療の現状と課題
    　２．意識障害
    　３．痙攣・行動異常
    　４．入浴中の事故
    　５．本邦における高齢者の熱中症
    　６．低体温症、凍瘡・凍傷

    XIV　高齢者のリハビリテーション
    　１．高齢者のリハビリテーションの特徴
    　２．高齢者の理学療法：現状と展望
    　３．認知症高齢者に対する人間作業モデルを用いたアプローチ
    　　　　～意味のある作業の提供が認知症者を変える～
    　４．言語聴覚療法
    　５．ロボットと転倒予防リハビリテーション
    　６．高齢者介護：福祉用具と介護

    XV　 老年看護学
    　１． 老年看護学を老年医学・高齢者診療に生かす
    　２．高齢者の生活を支えるが重視される背景と老年看護学の方向性
    　３．さまざまな健康状態に応じた高齢者の看護
    　４．多様な生活の場で展開する高齢者への看護
    　５．高齢者に特有な疾患への看護におけるアセスメントとケア
    　６．高齢者に特有な症状・障害への看護におけるアセスメントとケア

    XVI 学際的立場からの高齢者医療・介護
    　１．高齢者の介護とは
    　２．これからのケアマネジャー
    　３．地域における高齢者ケア
    　４．老年社会科学を老年医学・高齢者診療に生かす

この書籍の参考文献

参考文献のリンクは、リンク先の都合等により正しく表示されない場合がありますので、あらかじめご了承下さい。

本参考文献は電子書籍掲載内容を元にしております。

序文

P.6 掲載の参考文献
1) 日本老年学会・日本老年医学会 : 「高齢者に関する定義検討ワーキンググループ」報告書. 日本老年学会・日本老年医学会, 2017. [https://www.jpn-geriat-soc.or.jp/info/topics/pdf/20170410_01_01.pdf] (2018年4月閲覧)
 
2) 大島伸一, ほか : 提言「超高齢社会のフロントランナー日本 : これからの日本の医学・医療のあり方」. 日本学術会議 臨床医学委員会 老化分科会, 2014. [http://www.scj.go.jp/ja/info/kohyo/pdf/kohyo-22-t197-7.pdf] (2018年4月閲覧)
 

IX 高齢者の精神疾患

P.18 掲載の参考文献
1) Wimo A, et al : The worldwide costs of dementia 2015 and comparisons with 2010. Alzheimers Dement 13 : 1-7, 2017.
PubMed
2) Alzheimer's Disease International : World Alzheimer Report 2015 : The Global Impact of Dementia. [https://www.alz.co.uk/research/WorldAlzheimerReport2015.pdf] (2018年7月閲覧)
 
3) Ngandu T, et al : A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER) : a randomised controlled trial. Lancet 385 : 2255-2263, 2015.
 
4) Pedersen JT, Sigurdsson EM : Tau immunotherapy for Alzheimer's disease. Trends Mol Med 21 : 394-402, 2015.
PubMed
P.24 掲載の参考文献
1) Ohara T, et al : Trends in dementia prevalence, incidence, and survival rate in a Japanese community. Neurology 88 : 1925-1932, 2017.
 
2) 朝田隆 (代表研究者) : 厚生労働科学研究費補助金 疾病・障害対策研究分野 認知症対策総合研究 : 都市部における認知症有病率と認知症の生活機能障害への対応 (H23-認知症-指定-004), 2013. [https://mhlw-grants.niph.go.jp/niph/search/NIDD00.do?resrchNum=201218011A] (2018年6月閲覧)
 
3) 二宮利治 (代表研究者) : 厚生労働科学研究費補助金 行政政策研究分野 厚生労働科学特別研究 : 日本における認知症の高齢者人口の将来推計に関する研究 (H26-特別-指定-036), 2017. [https://mhlw-grants.niph.go.jp/niph/search/NIDD00.do?resrchNum=201405037A] (2018年6月閲覧)
 
4) 佐渡充洋 (代表研究者) : 厚生労働科学研究費補助金 疾病・障害対策研究分野 認知症対策総合研究 : わが国における認知症の経済的影響に関する研究 (H25-認知症-一般-005), 2016. [https://mhlw-grants.niph.go.jp/niph/search/NIDD00.do?resrchNum=201418007A] (2018年6月閲覧)
 
5) Livingston G, et al : Dementia prevention, intervention, and care. Lancet 390 : 2673-2734, 2017.
PubMed
6) Ohara T, et al : Apolipoprotein genotype for prediction of Alzheimer's disease in older Japanese : the Hisayama Study. J Am Geriatr Soc 59 : 1074-1079, 2011.
PubMed
7) Anttila V, et al : Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nat Genet 45 : 912-917, 2013.
PubMed
8) Ninomiya T, et al : Midlife and late-life blood pressure and dementia in Japanese elderly : the Hisayama study. Hypertension 58 : 22-28, 2011.
PubMed
9) Oishi E, et al : Day-to-Day Blood Pressure Variability and Risk of Dementia in a General Japanese Elderly Population : The Hisayama Study. Circulation 136 : 516-525, 2017.
 
10) Ohara T, et al : Glucose tolerance status and risk of dementia in the community : the Hisayama study. Neurology 77 : 1126-1134, 2011.
PubMed
11) Ohara T, et al : Midlife and Late-Life Smoking and Risk of Dementia in the Community : The Hisayama Study. J Am Geriatr Soc 63 : 2332-2339, 2015.
PubMed
12) Aarsland D, et al : Is physical activity a potential preventive factor for vascular dementia? A systematic review. Aging Ment Health 14 : 386-395, 2010.
PubMed
13) Kishimoto H, et al : The long-term association between physical activity and risk of dementia in the community : the Hisayama Study. Eur J Epidemiol 31 : 267-274, 2016.
 
14) Ozawa M, et al : Dietary patterns and risk of dementia in an elderly Japanese population : the Hisayama Study. Am J Clin Nutr 97 : 1076-1082, 2013.
 
P.28 掲載の参考文献
1) Barnes DE, et al : The projected effect of risk factor reduction on Alzheimer's disease prevalence. Lancet Neurol 10 : 819-828, 2011.
PubMed
2) Gray SL, et al : Cumulative use of strong anticholinergics and incident dementia : a prospective cohort study. JAMA Intern Med 175 : 401-407, 2015.
PubMed
3) Weytingh MD, et al : Reversible dementia : more than 10% or less than 1%? A quantitative review. J Neurol 242 : 466-471, 1995.
PubMed
4) 日本正常圧水頭症学会特発性正常圧水頭症診療ガイドライン作成委員会 (編) : 特発性正常圧水頭症ガイドライン 第2版, メディカルビュー, 2011.
 
5) 日本神経学会 (監), 「認知症疾患診療ガイドライン」作成委員会 (編) : 認知症疾患診療ガイドライン 2017, 医学書院, 2017.
 
6) Weiner MW, et al : 2014 Update of the Alzheimer's Disease Neuroimaging Initiative : A reiew of papers published since its inception. Alzheimer's Dement 11 : e1-e120, 2015.
 
7) Gross RA : Spotlight on the July 4 issue, Neurology 89 : 1, 2017.
PubMed
8) Shinagawa S, et al : Initial symptoms in frontotemporal dementia and semantic dementia compared with Alzheimer's disease. Dement Geriatr Cogn Disord 21 : 74-80, 2006.
PubMed
P.34 掲載の参考文献
1) 国際老年精神医学会 : 認知症の行動と心理症状BPSD 第2版, アルタ出版, 2013.
 
2) McKeith I, Cummings J : Behavioural changes and psychological symptoms in dementia disorders. Lancet Neurol 4 : 735-742, 2005.
PubMed
3) 日本神経学会 (監修), 「認知症疾患診療ガイドライン」作成委員会 (編集) : 認知症疾患診療ガイドライン 2017, 医学書院, 2017.
 
4) Terum TM, et al : The relationship of specific items on the Neuropsychiatric Inventory to caregiver burden in dementia : a systematic review, Int J Geriatr Psychiatry 32 : 703-717, 2017.
PubMed
5) 中島健二, ほか : 認知症ハンドブック, 医学書院, 2013.
 
6) 日本認知症学会 (編) : 認知症テキストブック, 中外医学社, 2008.
 
7) かかりつけ医のためのBPSDに対応する向精神薬使用ガイドライン (第2版). [http://www.mhlw.go.jp/stf/seisakunitsuite/bunya/0000135953.html.] (2018年6月閲覧)
 
8) Kim SK, Park M : Effectiveness of person-centered care on people with dementia : a systematic review and meta-analysis. Clin Interv Aging 12 : 381-397, 2017.
PubMed
9) van der Steen JT, et al : Music-based therapeutic interventions for people with dementia, Cochrane Database Syst Rev 5 : CD003477, 2017.
PubMed
10) Forbes D, et al : Light therapy for improving cognition, activities of daily living, sleep, challenging behaviour, and psychiatric disturbances in dementia. Cochrane Database Syst Rev CD003946, 2014.
PubMed
11) Aguirre E, et al : Cognitive stimulation for dementia : a systematic review of the evidence of effectiveness from randomised controlled trials. Ageing Res Rev 12 : 253-262, 2013.
PubMed
12) Barreto Pde S, et al : Exercise training for managing behavioral and psychological symptoms in people with dementia : A systematic review and meta-analysis. Ageing Res Rev 24 : 274-285, 2015.
PubMed
13) Huang HC, et al : Reminiscence Therapy Improves Cognitive Functions and Reduces Depressive Symptoms in Elderly People With Dementia : A Meta-Analysis of Randomized Controlled Trials. J Am Med Dir Assoc 16 : 1087-1094, 2015.
PubMed
14) Forrester LT, et al : Aromatherapy for dementia. Cochrane Database Syst Rev CD003150, 2014.
PubMed
15) Tricco AC, et al : Comparative Effectiveness and Safety of Cognitive Enhancers for Treating Alzheimer's Disease : Systematic Review and Network Metaanalysis. J Am Geriatr Soc 66 : 170-178, 2018.
PubMed
16) Matsunaga S, et al : Cholinesterase Inhibitors for Lewy Body Disorders : A Meta-Analysis. Int J Neuropsychopharmacol 19 : pyv086, 2015.
 
17) Kishi T, et al : Memantine for Alzheimer's Disease : An Updated Systematic Review and Meta-analysis. J Alzheimers Dis 60 : 401-425, 2017.
PubMed
18) Kishi T, et al : The effects of memantine on behavioral disturbances in patients with Alzheimer's disease : a meta-analysis. Neuropsychiatr Dis Treat 13 : 1909-1928, 2017.
PubMed
19) Matsunaga S, et al : Memantine for Lewy body disorders : systematic review and meta-analysis. Am J Geriatr Psychiatry 23 : 373-383, 2015.
PubMed
20) Emre M, et al : Memantine for patients with Parkinson's disease dementia or dementia with Lewy bodies : a randomised, double-blind, placebo-controlled trial. Lancet Neurol 9 : 969-977, 2010.
PubMed
21) Matsunaga S, et al : Yokukansan in the Treatment of Behavioral and Psychological Symptoms of Dementia : An Updated Meta-Analysis of Randomized Controlled Trials. J Alzheimers Dis 54 : 635-643, 2016.
PubMed
22) Maher AR, et al : Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults : a systematic review and meta-analysis. JAMA 306 : 1359-1369, 2011.
PubMed
23) Seitz DP, et al : Antidepressants for agitation and psychosis in dementia. Cochrane Database Syst Rev CD008191, 2011.
PubMed
24) Leong C : Antidepressants for depression in patients with dementia : a review of the literature. Consult Pharm 29 : 254-263, 2014.
PubMed
25) Orgeta V, et al : Efficacy of Antidepressants for Depression in Alzheimer's Disease : Systematic Review and Meta-Analysis. J Alzheimers Dis 58 : 725-733, 2017.
PubMed
26) Lonergan E, Luxenberg J : Valproate preparations for agitation in dementia. Cochrane Database Syst Rev CD003945, 2009.
PubMed
27) Yeh YC, Ouyang WC : Mood stabilizers for the treatment of behavioral and psychological symptoms of dementia : an update review. Kaohsiung J Med Sci 28 : 185-193, 2012.
PubMed
28) 武地一 : 認知症と共に生きるための新しい仕組みづくり. 日本認知症学会誌 32 : 81-88, 2018.
 
P.39 掲載の参考文献
1) Birks J : Cholinesterase inhibitors for Alzheimer's disease. Cochrane Database Syst Rev CD005593, 2006.
PubMed
2) Tariot PN, et al : Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil : a randomized controlled trial. JAMA 291 : 317-324, 2004.
PubMed
3) Mori E, et al : Donepezil for dementia with Lewy bodies : a randomized, placebo-controlled trial. Ann Neurol 72 : 41-52, 2012.
PubMed
4) Ikeda M, et al : Donepezil for dementia with Lewy bodies : a randomized, placebo-controlled, confirmatory phase III trial. Alzheimers Res Ther 7 : 4. 2015
PubMed
5) McKeith I, et al : Efficacy of rivastigmine in dementia with Lewy bodies : a randomised, double-blind, placebo-controlled international study. Lancet 356 : 2031-2036, 2000.
 
6) Mintzer J, et al : Olanzapine in the treatment of anxiety symptoms due to Alzheimer's disease : a post hoc analysis. Int J Geriatr Psychiatry 16 (Suppl 1) : S71-77, 2001.
 
7) Suh GH, et al : Comparative efficacy of risperidone versus haloperidol on behavioural and psychological symptoms of dementia. Int J Geriatr Psychiatry 21 : 654-660, 2006.
PubMed
8) Savaskan E, et al : Treatment of behavioural, cognitive and circadian rest-activity cycle disturbances in Alzheimer's disease : haloperidol vs. quetiapine. Int J Neuropsychopharmacol 9 : 507-516, 2006.
PubMed
9) Ballard C, Corbett A : Agitation and aggression in people with Alzheimer's disease. Curr Opin Psychiatry 26 : 252-259, 2013.
PubMed
10) Seitz DP, et al : Antidepressants for agitation and psychosis in dementia. Cochrane Database Syst Rev CD008191, 2011.
PubMed
11) Mizukami K, et al : A randomized cross-over study of a traditional Japanese medicine (kampo), yokukansan, in the treatment of the behavioural and psychological symptoms of dementia. Int J Neuropsychopharmacol 12 : 191-199, 2009.
PubMed
12) Feldman H, et al : A 24-week, randomized, double-blind study of donepezil in moderate to severe Alzheimer's disease. Neurology 57 : 613-620, 2001.
 
13) Leong C : Antidepressants for depression in patients with dementia : a review of the literature. Consult Pharm 29 : 254-263, 2014.
PubMed
14) Sepehry AA, et al : Effect of selective serotonin reuptake inhibitors in Alzheimer's disease with comorbid depression : a meta-analysis of depression and cognitive outcomes. Drugs Aging 29 : 793-806, 2012.
PubMed
15) Banerjee S, et al : Study of the use of antidepressants for depression in dementia : the HTA-SADD trial-a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine. Health Technol Assess 17 : 1-166, 2013.
 
P.44 掲載の参考文献
1) Glenner GG, et al : Alzheimer's disease : initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 120 : 885-890, 1984.
PubMed
2) Goate A, et al : Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349 : 704-706, 1991.
PubMed
3) Rogaev EI, et al : Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376 : 775-778, 1995.
 
4) Fitzpatrick AWP, et al : Cryo-EM structures of tau filaments from Alzheimer's disease. Nature 547 : 185-190, 2017.
PubMed
5) Hutton M, et al : Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17. Nature 393 : 702-705, 1998.
 
6) Gomez-Isla T, et al : Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J Neurosci 16 : 4491-4500, 1996.
PubMed
7) Ott A, et al : Diabetes mellitus and the risk of dementia : The Rotterdam Study. Neurology 53 : 1937-1942, 1999.
PubMed
8) Matsuzaki T, et al : Insulin resistance is associated with the pathology of Alzheimer disease : the Hisayama study. Neurology 75 : 764-770, 2010.
PubMed
9) Kalaria RN : Neurodegenerative disease : Diabetes, microvascular pathology and Alzheimer disease. Nat Rev Neurol 5 : 305-306, 2009.
PubMed
10) Sato N, et al : Roles of vascular and metabolic components in cognitive dysfunction of Alzheimer disease : short- and long-term modification by non-genetic risk factors. Front Aging Neurosci 5 : 64, 2013.
 
P.48 掲載の参考文献
1) McKhann G, et al : Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34 : 939-944, 1984.
PubMed
2) Petersen RC, et al : Current concepts in mild cognitive impairment. Arch Neurol 58 : 1985-1992, 2001.
PubMed
3) Winblad B, et al : Mild cognitive impairment--beyond controversies, towards a consensus : report of the International Working Group on Mild Cognitive Impairment. J Intern Med 256 : 240-246, 2004.
 
4) Glenner GG, Wong CW : Alzheimer's disease : initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 120 : 885-890, 1984.
PubMed
5) Rogers SL, et al : A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease. Donepezil Study Group. Neurology 50 : 136-145, 1998.
 
6) 荒井啓行, 古川勝敏 : 脳脊髄液タウ蛋白測定の認知症診断への適応と保険収載. 医学のあゆみ 243 : 247-248, 2012.
Medical*Online
7) 荒井啓行, ほか : アルツハイマー病新薬開発の動向. 日本臨牀 74 : 411-416, 2016.
Medical*Online
8) Sperling RA, et al : Toward defining the preclinical stages of Alzheimer's disease : recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 7 : 280-292, 2011.
PubMed
9) Albert MS, et al : The diagnosis of mild cognitive impairment due to Alzheimer's disease : recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 7 : 270-279, 2011.
PubMed
10) McKhann GM, et al : The diagnosis of dementia due to Alzheimer's disease : recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 7 : 263-269, 2011.
 
11) 荒井啓行 : 進化するアルツハイマー病の概念と本学会の使命. 日本認知症予防学会誌 7 : 1, 2017.
 
12) Sperling RA, et al : The A4 study : stopping AD before symptoms begin? Sci Transl Med 6 : 228fs13, 2014.
PubMed
13) Bateman RJ, et al : Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N Engl J Med 367 : 795-804, 2012.
PubMed
14) [https://www.usagainstalzheimers.org/networks/researchers]
 
P.53 掲載の参考文献
1) 厚生労働省ホームページ : 認知症施策-1. 認知症に対する取り組み. [http://wwwmhlw.go.jp/stf/seisakunitsuite/bunya/0000076236.html] (2018年6月閲覧)
 
2) 博野信次 : 臨床認知症学入門-正しい診療・正しいリハビリテーションとケア, p11-13. 金芳堂, 2001.
 
3) 池田学 : 厚生労働科学研究費補助金長寿科学総合研究事業「生活行為障害の分析に基づく認知症リハビリテーションの標準化に関する研究」平成27年度総括・分担報告書, p1-3, 2016.
 
4) 堀田牧 : AD-ADL評価表により服薬管理の生活行為障害があった在宅軽度AD患者に対してリハビリ介入を施行した一例. 厚生労働科学研究費補助金長寿科学総合研究事業「生活行為障害の分析に基づく認知症リハビリテーションの標準化に関する研究」平成29年度総括・分担報告書 (主任研究者 : 池田学), 2018.
 
5) 伊藤利之 : 日常生活活動 (ADL) の概念と範囲. ADLとその周辺 評価・指導・介護の実際 (伊藤利之, 鎌倉矩子編), p2-3, 医学書院, 1994.
 
6) 松村秩 : 生活関連活動, 日常生活活動 (動作) 評価の訓練と実際 (土屋弘吉, ほか編), p67-72, 医歯薬出版, 1992.
 
7) 堀田牧, ほか : アルツハイマー病患者のADL障害. 老年精神医学雑誌 28 : 984-988, 2017.
Medical*Online
8) 池田学 : ADの生活行為障害の要因分析と評価モデルの作成. 厚生労働科学研究費補助金長寿科学総合研究事業「生活行為障害の分析に基づく認知症リハビリテーションの標準化に関する研究」平成28年度総括・分担報告書, 2017.
 
9) 柴喜崇, 下田信明 (編) : PT・OTビジュアルテキストADL, p21-25, 羊土社, 2015.
 
P.59 掲載の参考文献
1) 櫻井博文, ほか : 大学病院側からみた病診連携の現状と課題. Progress in Medicine 34 : 841-843, 2014.
Medical*Online
2) 櫻井博文 : 認知症疾患医療センターへの取り組み. 東医大誌 75 : 66-73, 2017.
Medical*Online
3) 櫻井博文, 羽生春夫 : 専門外来としての「もの忘れ外来」の現状. 日本臨牀 (増刊号 1) 76 : 404-409, 2018.
 
4) 内海久美子, 粟田主一 : 認知症疾患医療センターの現状と課題. 日本臨牀 (増刊号 1) 76 : 410-415, 2018.
 
5) Sakurai H, et al : Factors associated with the burden of caregivers of patients with dementia. Geriatr Gerontol Int 15 : 384-385, 2015.
PubMed
6) Terayama H, Sakurai H et al : Caregivers' education decreases depressive symptoms and burden in caregivers of patients with dementia Int Psychogeriatr. (doi : 10.1111/psyg. 12337).
 
7) Sakurai H, Hanyu H : Effects of day service use on the progression of Alzheimer's disease. J Am Geriatr Soc 62 : 1383-1384, 2014.
PubMed
8) 粟田主一 : わが国の認知症施策と新オレンジプラン, 日本臨牀 (増刊号 1) 76 : 397-403, 2018.
 
P.65 掲載の参考文献
1) 三村將 : 運転と認知機能. Modern Physician 37 : 157-160, 2017.
 
2) 馬場美年子 : 認知症を取り巻く問題 : 認知症患者の自動車運転. 日本老年医学会雑誌 53 : 216-221, 2016.
 
3) 池田学 : 医療的側面からみた改正道路交通法に関して. 老年精神医学雑誌 29 (増刊 1) : 46-55, 2018.
 
4) 警察庁 : 第1回 高齢運転者交通事故防止対策に関する有識者会議. 「認知機能と安全運転の関係に関する調査研究」分科会. 2018年3月2日. [https://www.npa.go.jp/koutsuu/kikaku/koureiunt-en/menkyoseido-bunkakai/cognitivef/c1_minute.pdf] (2018年6月閲覧)
 
5) Carr DB, et al : Older adult drivers with cognitive impairment. Am Fam Physician 73 : 1029-1034, 2006.
PubMed
6) Marottoli RA, et al : Driving cessation and increased depressive symptoms : prospective evidence from the New Haven EPESE. Established Populations for Epidemiologic Studies of the Elderly. J Am Geriatr Soc 45 : 202-206, 1997.
PubMed
7) Fonda SJ, et al : Changes in driving Patterns and worsening depressive symptoms among older adults. J Gerontol B Psychol Sci Soc Sci 56 : s343-351, 2001.
PubMed
8) Ragland DR, et al : Driving cessation and increased depressive symptoms. J Gerontol A Biol Sci Med Sci 60 : 399-403, 2005.
PubMed
9) 内閣府 : 平成17年度高齢者の住宅と生活環境に関する意識調査結果.
 
10) 警察庁 : 平成17年警察白書.
 
11) 荒井由美子, ほか : 認知症高齢者の自動車運転を考える家族介護者のための支援マニュアル (C). 第2版. [http://www.ncgg.go.jp/cgss/department/dgp/index.html] (2018年6月閲覧)
 
12) 荒井由美子, 水野洋子 : 認知症に罹患した高齢運転者および, その家族介護者への支援 : 「認知症高齢者の自動車運転を考える家族介護者のための支援マニュアル (C)」の概要および作成の背景となった調査の結果. 老年精神医学雑誌 29 : 61-67, 2018.
 
13) Mizuno Y, Arai Y : Drivers with dementia in Japan : required public support under strict legal restrictions. J Am Geriatr Soc 63 : 611-612, 2015.
PubMed
14) Mizuno Y, Arai Y : Is Society Tolerant Enough to Give the Necessary Priority to Vulnerable Adults When They Need Mobility Support? J Am Geriatr Soc 64 : 1741-1743, 2016.
PubMed
15) 水野洋子, 荒井由美子 : 認知症罹患運転者 : 現行法の射程及び求められる支援の方向性. Modern Physician 37 : 133-137, 2017.
 
P.69 掲載の参考文献
1) 馬場元 : 精神科の疾患と認知症との関連 Update, うつ病と認知症との関連-リスクか部分症状か. 老年精神医学雑誌 29 : 20-28, 2018.
 
2) Barnes DE, Yaffe K : The projected effect of risk factor reduction on Alzheimer's disease prevalence. Lancet Neurol 10 : 819-828, 2011.
PubMed
3) 馬場元 : 認知症の前駆状態としてのうつ病の鑑別と対応. 臨床精神医学 42 : 961-968, 2013.
Medical*Online
4) 馬場元 : 認知症の危険因子と防御因子 : うつ病・双極性障害と認知症. BRAIN and NERVE : 神経研究の進歩 68 : 753-765, 2016.
 
5) da Silva J, et al : Affective disorders and risk of developing dementia : systematic review. Br J Psychiatry 202 : 177-186, 2013.
PubMed
6) Singh-Manoux A, et al : Trajectories of Depressive Symptoms Before Diagnosis of Dementia : A 28-Year Follow-up Study. JAMA Psychiatry 74 : 712-718, 2017.
PubMed
7) Kita Y, et al : Serum amyloid beta protein in young and elderly depression : a pilot study. Psychogeriatrics 9 : 180-185, 2009.
 
8) Baba H, et al : Metabolism of amyloid-β protein may be affected in depression. J Clin Psychiatry 73 : 115-120, 2012.
 
9) Namekawa Y, et al : Heterogeneity of elderly depression : increased risk of Alzheimer's disease and Aβ protein metabolism. Prog Neuropsychopharmacol Biol Psychiatry 43 : 203-208, 2013.
 
10) Ishijima S, et al : Glucocorticoid may influence amyloidβ metabolism in patients with depression. Psychiatry Res 259 : 191-196, 2018.
 
11) Yamamoto K, et al : Serum levels of albumin-amyloid beta complexes are decreased in Alzheimer's disease. Geriatr Gerontol Int 14 : 716-723, 2014.
PubMed
12) Inoue M, et al : Serum levels of albumin-β-amyloid complex in patients with depression. Am J Geriatr Psychiatry 24 : 764-772, 2016.
 
13) 門司晃 : 高齢者の気分障害と認知症の関係およびその背景メカニズム. 臨床精神薬理 19 : 1663-1673, 2016.
 
P.75 掲載の参考文献
1) Okada K, Yamaguchi S : Apathy and Dementia. Brain Nerve 68 : 767-778, 2016.
PubMed
2) van Dalen JW, et al : Apathy is associated with incident dementia in community-dwelling older people. Neurology 90 : e82-e89, 2018.
PubMed
3) 山口修平 : アパシー (意欲障害) とは-神経内科の立場から-. : 脳疾患によるアパシー (意欲障吾) の臨床, 改訂版 (小林祥泰編). p11-18, 新興医学出版社, 2016.
 
4) Le Heron C, Apps MAJ, Husain M : The anatomy of apathy : A neurocognitive framework for amotivated behaviour. Neuropsychologia, 2017. (doi : 10.1016/j. neuropsychologia. 2017. 07. 003)
 
5) Radakovic R, Abrahams S : Developing a new apathy measurement scale : Dimensional Apathy Scale. Psychiatry Res 219 : 658-663, 2014.
PubMed
6) Levy R, Dubois B : Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits. Cereb Cortex 16 : 916-928, 2006.
PubMed
7) Robert P, et al : Proposed diagnostic criteria for apathy in Alzheimer's disease and other neuropsychiatric disorders. Eur Psychiatry 24 : 98-104, 2009.
PubMed
8) Onoda K, Yamaguchi S : Dissociative contributions of the anterior cingulate cortex to apathy and depression : Topological evidence from resting-state functional MRI. Neuropsychologia 77 : 10-18, 2015.
PubMed
9) Hollocks MJ, et al : Differential relationships between apathy and depression with white matter microstructural changes and functional outcomes. Brain 138 : 3803-3815, 2015.
PubMed
10) Lohner V, et al : Apathy, but not depression, is associated with executive dysfunction in cerebral small vessel disease. PLoS ONE 12 : e0176943, 2017.
 
11) Kawagoe T, et al : Apathy and Executive Function in Healthy Elderly-Resting State fMRI Study. Front Aging Neurosci 9 : 124, 2017.
PubMed
12) Takayoshi H, et al : Do Event-Related Evoked Potentials Reflect Apathy Tendency and Motivation? Front Hum Neurosci 12 : 11, 2018.
PubMed
13) Onoda K, et al : Post-stroke apathy and hypoperfusion in basal ganglia : SPECT study. Cerebrovasc Dis 31 : 6-11, 2011.
PubMed
14) Mitaki S, et al : The Effectiveness of Repetitive Transcranial Magnetic Stimulation for Poststroke Apathy Is Associated with Improved Interhemispheric Functional Connectivity. J Stroke Cerebrovasc Dis 25 : e219-e221, 2016.
PubMed
15) Sasaki N, et al : The Efficacy of High-Frequency Repetitive Transcranial Magnetic Stimulation for Improving Apathy in Chronic Stroke Patients. Eur Neurol 78 : 28-32, 2017.
PubMed
P.80 掲載の参考文献
1) American Psychiatric Association : Diagnostic and Statistical Manual of Mental Disorders, 5th (DSM-5), American Psychiatric Pub, Washington DC, 2013.
 
2) World Health Organization : The ICD-10 Classification of Mental and Behavioural Disorders ; Clinical Description and Diagnostic Guidelines. WHO, Genava, 1992.
 
3) Cassidy KL, Rector NA : The Silent Geriatric Giant : Anxiety Disorders in Late Life. Geriatrics and Aging 11 : 150-156, 2008.
 
4) Fuentes K, Cox BJ : Prevalence of anxiety disorders in elderly adults : a critical analysis. J Behav Ther Exp Psychiatry 28 : 269-279, 1997.
PubMed
5) Blazer DG, Steffens DC (Eds) : Textbook of Geriatric Psychiatry. American Psychiatric Pub, Washington DC, 2009.
 
6) Regier DA, et al : One-month prevalence of mental disorders in the United States. Based on five Epidemiologic Catchment Area sites. Arch Gen Psychiatry 45 : 977-986, 1988.
PubMed
7) Krasucki C, et al : Anxiety and its treatment in the elderly. Int Psychogeriatr 11 : 25-45, 1999.
PubMed
8) Bland RC, et al : Prevalence of psychiatric disorders in the elderly in Edmonton. Acta Psychiatr Scand Suppl 338 : 57-63, 1988.
PubMed
9) Wolitzky-Taylor KB, et al : Anxiety disorders in older adults : a comprehensive review. Depress Anxiety 27 : 190-211, 2010.
PubMed
10) Zhang X, et al : Risk factors for late-onset generalized anxiety disorder : results from a 12-year prospective cohort (the ESPRIT study). Transl Psychiatry 5 : e536, 2015. (doi : 10.1038/tp. 2015. 31.)
 
11) Wittchen HU, et al : DSM-III-R generalized anxiety disorder in the National Comorbidity Survey. Arch Gen Psychiatry 51 : 355-364, 1994.
PubMed
12) The National Institute of Clinical Excellence (NICE) : Management of Anxiety (Panic Disorder, with or without Agoraphobia, and Generalized Anxiety Disorder) in Adults in Primary, Secondary and Community Care. RCPsych Publications, London, 2011.
 
13) Howland J, et al : Fear of falling among the community-dwelling elderly. J Aging Health 5 : 229-243, 1993.
PubMed
14) Ballard C, et al : Anxiety, depression and psychosis in vascular dementia : prevalence and associations. J Affect Disord 59 : 97-106, 2000.
PubMed
15) Lenze EJ, Wetherell JL : A lifespan view of anxiety disorders. Dialogues Clin Neurosci 13 : 381-399, 2011.
PubMed
16) 厚生労働省 : 平成27年人口動態調査 不慮の事故死亡統計の概況.
 
17) Boyd R, Stevens JA : Falls and fear of falling : burden, beliefs and behaviours. Age Ageing 38 : 423-428, 2009.
PubMed
18) Cairney J, et al : Epidemiology of social phobia in later life. Am J Geriatr Psychiatry 15 : 224-233, 2007.
PubMed
19) Bryant C, et al : Anxiety disorders in older adults : looking to DSM5 and beyond... Am J Geriatr Psychiatry 21 : 872-876, 2013.
PubMed
20) Livingston G, et al : The natural history of depression and the anxiety disorders in older people : the Islington community study. J Affect Disord 46 : 255-262, 1997.
PubMed
21) Hassan R, Pollard CA : Late-Life-Onset Panic Disorder : Clinical and Demographic Characteristics of a Patient Sample. J Geriatr Psychiatry Neurol 7 : 84-88, 1994.
 
22) Grenier S, et al : The impact of DSM-IV symptom and clinical significance criteria on the prevalance estimates of subthreshold and threshold of anxiety in the older adult population. Am J Geriatr Psychiatry. 19 : 316-326, 2011. .
 
23) Blazer DG : Generalized anxiety disorder and panic disorder in the elderly : a review. Harv Rev Psychiatry 5 : 18-27, 1997.
PubMed
24) 井藤英喜 : 糖尿病 最新内科学大系 79 関連領域疾患3老年の診療 (井村裕夫, ほか編), p204-209, 中山書店, 1995.
 
25) Beekman AT, et al : Anxiety and depression in later life : Co-occurrence and communality of risk factors. Am J Psychiatry 157 : 89-95, 2000.
PubMed
26) Goodwin RD : Anxiety disorders and the onset of depression among adults in the community. Psychol Med 32 : 1121-1124, 2002.
PubMed
27) Lieb R, et al : Epidemiology of the association between somatoform disorders and anxiety and depressive disorders : an update. Psychosom Med 69 : 860-863, 2007.
PubMed
28) McWilliams LA, et al : Mood and anxiety disorders associated with chronic pain : an examination in a nationally representative sample. Pain 106 : 127-133, 2003.
 
29) Palmer K, et al : Predictors of progression from mild cognitive impairment to Alzheimer disease. Neurology 68 : 1596-1602, 2007.
PubMed
30) Mackenzie CS, et al : Prevalence and correlates of generalized anxiety disorder in anational sample of older adults. Am J Geriatr Psychiatry 19 : 305-315, 2011
 
31) Hanrahan F, et al : A meta-analysis of cognitive therapy for worry in generalized anxiety disorder. Clin Psychol Rev 33 : 120-132, 2013.
PubMed
32) Rickels K, et al : Antidepressants for the treatment of generalized anxiety disorder. A placebocontrolled comparison of imipramine, trazodone, and diazepam. Arch Gen Psychiatry 50 : 884-895, 1993.
PubMed
33) Bower ES, et al : Treating Anxiety Disorders in Older Adults : Current Treatments and Future Directions. Harv Rev Psychiatry 23 : 329-342, 2015.
PubMed
34) Andreescu C, Varon D : New research on anxiety disorders in the elderly and an update on evidencebased treatments. Curr Psychiatry Rep 17 : 53, 2015.
 
35) Katz IR, et al : Venlafaxine ER as a treatment for generalized anxiety disorder in older adults : pooled analysis of five randomized placebo-controlled clinical trials. J Am Geriatr Soc 50 : 18-25, 2002.
 
36) Lenze EJ, et al : Efficacy and tolerability of citalopram in the treatment of late-life anxiety disorders : results from an 8-week randomized, placebo-controlled trial. Am J Psychiatry 162 : 146-150, 2005.
PubMed
37) Lauderdale SA, Sheikh JI : Anxiety disorders in older adults. Clin Geriatr Med 19 : 721-741, 2003.
 
38) Davidson JR : Use of benzodiazepines in social anxiety disorder, generalized anxiety disorder, and posttraumatic stress disorder. J Clin Psychiatry 65 (Suppl 5) : 29-33, 2004.
 
39) Filteau MJ, et al : SSRIs in anxious-agitated depression : apost-hoc analysis of 279 patients. Int Clin Psychopharmacol 10 : 51-54, 1995.
 
40) Lang AJ, Stein MB : Anxiety disorders. How to recognize and treat the medical symptoms of emotional illness. Geriatrics 56 : 24-27, 31-34, 2001.
 
41) Tueth MJ : Anxiety in the older patient : differential diagnosis and treatment, Geriatrics 48 : 51-54, 1993.
PubMed
42) Gale CK, Millichamp J : Generalized anxiety disorder. BMJ Clin Evid pii : 1002, 2011.
 
43) Bandelow B, et al : The diagnosis of and treatment recommendations for anxiety disorders. Dtsch Arztebl Int 111 : 473-480, 2014.
PubMed
44) LaLonde CD, Van Lieshout RJ : Treating generalized anxiety disorder with second generation antipsychotics : a systematic review and meta-analysis. J Clin Psychopharmacol 31 : 326-333, 2011.
PubMed
45) 赤尾清剛, ほか : 抑肝散の応用. 日本東洋医学雑誌 62 : 479-508, 2011.
 
46) de Caires S, Steenkamp V : Use of Yokukansan (TJ-54) in the treatment of neurological disorders : a review. Phytother Res 24 : 1265-1270, 2010.
PubMed
47) Flint AJ, Gagnon N : Diagnosis and management of panic disorder in older patients. Drugs Aging 20 : 881-891, 2003.
PubMed
48) Lenze EJ, et al : Somatic symptoms in late-life anxiety : treatment issues. J Geriatr Psychiatry Neurol 18 : 89-96, 2005.
PubMed
49) Wilson RS, et al : Vulnerability to stress, anxiety, and development of dementia in old age. Am J Geriatr Psychiatry 19 : 327-334, 2011.
 
50) Wetherell JL, et al : Quality of life in geriatric generalized anxiety disorder : a preliminary investigation. J Psychiatr Res 38 : 305-312, 2004.
PubMed
P.87 掲載の参考文献
1) Ekselius L, et al : Personality disorders in DSM-III-R as categorical or dimensional. Acta Psychiatr Scand 88 : 183-187, 1993.
PubMed
2) Costa PT, McCrae RR : Revised NEO Personality Inventory and NEO Five-Factor inventory : Professional manual, Psychological Assessment Resources, Odessa FL, 1992.
 
3) Roberts BW, et al : Patterns of mean-level change in personality traits across the life course : a metaanalysis of longitudinal studies. Psychol Bull 132 : 1-25, 2006.
PubMed
4) Srivastava S, et al : Development of personality in early and middle adulthood : set like plaster or persistent change? Jpers Soc Psychol 5 : 1041-1053, 2003.
PubMed
5) Steunenberg B, et al : Stability and change of neuroticism in aging. J Gerontol B Psychol Sci Soc Sci 60 : 27-33, 2005.
 
6) Kenan MM, et al : Age-related differences in the frequency of personality disorders among inpatient veterans. Int J Geriatr Psychiatry 15 : 831-837, 2000.
PubMed
7) Solomon K : Personality disorders in the elderly. In : Personality Disorders, Diagnosis and Management (ed by Lion JR). Williams & Wilkins, Baltimore, p310-338, 1981.
 
8) Black DW, et al : A 16- to 45-year follow-up of 71 men with antisocial personality disorder. Compr Psychiatry 36 : 130-140, 1995.
PubMed
9) Rosowsky E, Gurian B : Borderline personality disorder in late life. Int Psychogeriatr 3 : 39-52, 1991.
PubMed
10) Lautenschlager NT, Forstl H : Personality change in old age. Curr Opin Psychiatry 20 : 62-66, 2007.
PubMed
11) Abrams RC, et al : Personality disorders after age 50 : A meta-analysis. Journal of Personality Disorders 10 : 271-281, 1996.
 
12) Abrams RC, Bromberg CE : Personality disorders in the elderly : a flagging field of inquiry. Int J Geriatr Psychiatry 21 : 1013-1017, 2006.
PubMed
13) Van Alphen SP, et al : Features and challenges of personality disorders in late life. Aging Ment Health 16 : 805-810, 2012.
PubMed
14) Reich J, et al : Age and sex distribution of DSM-III personality cluster traits in a community population. Compr Psychiatry 29 : 298-303, 1988.
 
15) Sadavoy J : Character disorders in the elderly : an overview. In : Treating the Elderly with Psychotherapy : The Scope for Change in Late Life (ed by Sadavoy J, Leszcz M), p175-229, International Universities Press, Madison, 1987.
 
16) Schuster JP, et al : Personality disorders in older adults : findings from the National Epidemiologic Survey on Alcohol and Related Conditions. Am J Geriatr Psychiatry 21 : 757-768, 2013.
PubMed
17) Seidlitz L : Personality factors in mental disorders of later life. Am J Geriatr Psychiatry 9 : 8-21, 2001.
PubMed
18) Coid J, et al : Prevalence and correlates of personality disorder in Great Britain. Br J Psychiatry 188 : 423-431, 2006.
PubMed
19) Samuels J, et al : Prevalence and correlates of personality disorders in a community sample. Br J Psychiatry 180 : 536-542, 2002.
 
20) Schuster JP, Limosin F : 12. Les troubles de la personnalite chez le sujet age, In Les personnalites pathologiques (ed by Julien-Daniel Guelfi, et al), p92-96, Lavoisier, 2013.
 
21) Oltmanns TF, Balsis S : Personality disorders in later life : questions about the measurement, course, and impact of disorders. Annu Rev Clin Psychol 7 : 321-349, 2011.
PubMed
22) Balsis S, et al : An item response theory analysis of DSM-IV personality disorder criteria across younger and older age groups. Psychol Aging 22 : 171-185, 2007.
PubMed
23) Balsis S, et al : Overdiagnosis and underdiagnosis of personality disorders in older adults. Am J Geriatr Psychiatry 15 : 742-753, 2007.
PubMed
24) Agronin ME, Maletta G : Personality disorders in late life. Understanding and overcoming the gap in research. Am J Geriatr Psychiatry 8 : 4-18, 2000.
PubMed
25) Kunik ME, et al : Diagnostic rate of comorbid personality disorder in elderly psychiatric inpatients. Am J Psychiatry 151 : 603-605, 1994.
PubMed
26) Devanand DP, et al : Personality disorders in elderly patients with dysthymic disorder. Am J Geriatr Psychiatry 8 : 188-195, 2000.
PubMed
27) Nubukpo P, et al : Role of personality in depression of the elderly : difference between early and late life depression. Psychol Neuropsychiatr Vieil 3 : 63-69, 2005.
PubMed
28) Duberstein PR, et al : Personality and risk for Alzheimer's disease in adults 72 years of age and older : a 6-year follow-up. Psychol Aging 26 : 351-362, 2011.
 
29) Morse JQ, Lynch TR : A preliminary investigation of self-reported personality disorders in late life : prevalence, predictors of depressive severity, and clinical correlates. Aging Ment Health 8 : 307-315, 2004.
PubMed
30) Abrams RC, et al : Personality disorder symptoms and functioning in elderly depressed patients. Am J Geriatr Psychiatry 6 : 24-30, 1998.
PubMed
31) Abrams RC, et al : Personality disorders symptoms predict declines in global functionning and quality of life in elderly depressed patients. Am J Geriatr Psychiatry 9 : 67-71, 2001.
 
32) Heisel MJ, et al : Narcissistic personality and vulnerability to late-life suicidality. Am J Geriatr Psychiatry 15 : 734-741, 2007.
PubMed
33) Mendez MF, et al : Acquired sociopathy and frontotemporal dementia. Dement Geriatr Cogn Disord 20 : 99-104, 2005.
PubMed
34) Clement JP, Teissier MP : Personality and risk of dementia. Psychol Neuropsychiatr Vieil 8 : 243-254, 2010.
PubMed
35) De Leo D, et al : Pharmacological and psychotherapeutic treatment of personality disorders in the elderly. Int Psychogeriatr 11 : 191-206, 1999.
PubMed
P.92 掲載の参考文献
1) Hilderink PH, et al : Prevalence of somatoform disorders and medically unexplained symptoms in old age populations in comparison with younger age groups : a systematic review. Ageing Res Rev 12 : 151-156, 2013.
PubMed
2) American Psychiatric Association : Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), 2013.
 
3) American Psychiatric Association : Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR), 2000.
 
4) Onofrj M, et al : Cohort study on somatoform disorders in Parkinson disease and dementia with Lewy bodies. Neurology 74 : 1598-1606, 2010.
PubMed
5) Fujishiro H, et al : Dementia with Lewy bodies : early diagnostic challenges. Psychogeriatrics 13 : 128-138, 2013.
PubMed
6) 内閣府 : 平成28年版高齢社会白書, 2016.
 
7) 木村宏之 : 高齢者の心因-神経症から身体症状症 (DSM-5) へ-. 老年精神医学雑誌 27 : 1037-1045, 2016.
Medical*Online
8) Lautenschlager NT, Forstl H : Personality change in old age. Curr Opin Psychiatry 20 : 62-66, 2007.
PubMed
9) Freud S : On Psychotherapy SE. VII, HOGARTH PRESS 1905, (精神療法について小此木啓吾訳フロイト著作集第6巻, 人文書院)
 
10) Rechtschaffen A : Psychotherapy with geriatric patients : a review of the literature. J Gerontol 14 : 73-84, 1959.
PubMed
11) Abeles N ; APA working Group on the Older Adult Brochure : What practitioners should know about working with older adults. Professional Psychology Rsearch and Practice 29 : 413-427, 1998.
 
12) Sumathipala A : What is the evidence for the efficacy of treatments for somatoform disorders? A critical review of previous intervention studies. Psychosom Med 69 : 889-900, 2007.
PubMed
13) Koelen JA, et al : Effectiveness of psychotherapy for severe somatoform disorder : meta-analysis. Br J Psychiatry 204 : 12-19, 2014.
PubMed
14) Inamura K, et al : Executive Dysfunction Correlated With 2-Year Treatment Response in Patients With Late-Life Undifferentiated Somatoform Disorders. Psychosomatics 57 : 378-389, 2016.
PubMed
15) Abbey SE : Somatization and somatoform disorders. In : APP Textbook of consultation-liaison Psychiatry : Psychiatry in the Medically Ill, 2nd ed (ed by Wise MG, Rundel RJ), p361-392, American Psychiatric Press, Washington DC, 2002.
 
16) 成田善弘 : 心身症と心身医学-精神科医の眼, 岩波書店, 1999.
 
P.97 掲載の参考文献
1) Tatara T, et al : National Elder Abuse Incidence Study : Final Report. The National Center on Elder Abuse, New York, 1998.
 
2) 東京都福祉保健局 : 高齢者虐待防止に向けた体制構築のために-東京都高齢者虐待対応マニュアル-, 2006.
 
3) 津村智恵子, ほか : 高齢者のセルフ・ネグレクトに関する課題. 大阪市立大学看護学雑誌 2 : 1-10, 2006.
 
4) 野村祥平, ほか : 高齢者のセルフ・ネグレクトの理論的な概念と実証研究の課題に関する考察. 高齢者虐待防止研究 10 : 175-187, 2014.
 
5) 岸恵美子, ほか : 専門職がかかわる高齢者のセルフ・ネグレクト事例の実態と対応の課題 : 地域包括支援センターを対象とした全国調査の結果より. 高齢者虐待防止研究 7 : 125-138, 2011.
 
6) 厚生労働省老健局高齢者支援課 : 市町村や地域包括支援センターにおける高齢者の「セルフ・ネグレクト」及び消費者被害への対応について. 老推発0710第2号 (平成27年7月10日), 2015.
 
7) 内閣府経済社会総合研究所 : セルフ・ネグレクト状態にある高齢者に関する調査 ; 幸福度の視点から. 平成24年度内閣府経済社会総合研究所委託事業. 2012.
 
8) Dong X, et al : The prevalence of elder self-neglect in a community-dwelling population : hoarding, hygiene, and environmental hazards. J Aging Health 24 : 507-524, 2012.
 
9) Abrams RC, et al : Predictors of self-neglect in community-dwelling elders. Am J Psychiatry 159 : 1724-1730, 2002.
PubMed
10) Dong X, et al : Self-neglect and cognitive function among community-dwelling older persons. Int J Geriatr Psychiatry 25 : 798-806, 2010.
PubMed
11) Pay BK, Gainey RP : Differentiating self-neglect as a type of elder mistreatment : how do these cases compare to traditional types of elder mistreatment? J Elder Abuse Negl 17 : 21-36, 2005.
 
12) Spensley C : The role of social isolation of elders in recidivism of self-neglect cases at San Francisco Adult Protective Services. J Elder Abuse Negl 20 : 43-61, 2008.
 
13) Dong X, et al : Elder selfLneglect and abuse and mortality risk in a community-dwelling population. JAMA 302 : 517-526, 2009.
 
14) 岸恵美子, ほか (編) : セルフネグレクトの人への支援 ; ゴミ屋敷・サービス拒否・孤立事例への対応と予防, 中央法規出版, 2015.
 
15) Burnett J, et al : Four subtypes of self-neglect in older adults : results of a latent class analysis. J Am Geriatr Soc 62 : 1127-1132, 2014.
PubMed
16) 斉藤雅茂, ほか : 高齢者のセルフ・ネグレクト事例の類型化と孤立死との関連 ; 地域包括支援センターへの全国調査の二次分析. 厚生の指標 63 : 1-7, 2016.
Medical*Online
17) Dyer CB, et al : The making of a self-neglect severity scale. J Elder Abuse Negl 18 : 13-23, 2006.
PubMed
18) Kelly PA, et al : Exploring self-neglect in older adults : preliminary findings of the self-neglect severity scale and next steps. J Am Geriatr Soc 56 (Suppl 2) : S253-260, 2008.
 
19) Iris M, et al : The development of a conceptual model for understanding elder self-neglect. Gerontologist 50 : 303-315, 2010.
PubMed
20) あい権利擁護支援ネット : セルフ・ネグレクトや消費者被害等の犯罪被害と認知症との関連に関する調査研究事業報告書. 平成26年度厚生労働省老人保健健康増進等事業報告書, 2015.
 
P.102 掲載の参考文献
1) Ostling S, Skoog I : Psychotic symptoms and paranoid ideation in a nondemented population-based sample of the very old. Arch Gen Psychiatry 59 : 53-59, 2002.
 
2) Maglione JE, et al : Late-onset schizophrenia : do recent studies support categorizing LOS as a subtype of schizophrenia? Curr Opin Psychiatry 27 : 173-178, 2014.
PubMed
3) American Psychiatric Association : DSM-5 精神疾患の診断・統計マニュアル (日本精神神経学会監修, 高橋三郎, 大野裕監訳), 医学書院, 2014.
 
4) 新村秀人 : 統合失調症患者の高齢化に関する問題. 老年精神医学雑誌 28 : 873-878, 2017.
Medical*Online
5) Harrison G, et al : Recovery from psychotic illness : a 15- and 25-year international follow-up study. Br J Psychiatry 178 : 506-517, 2001.
PubMed
6) Maltais JR, et al : Correlation between age and MMSE in schizophrenia. Int Psychogeriatr 27 : 1769-1775, 2015.
PubMed
7) Saha S, et al : A systematic review of mortality in schizophrenia : is the differential mortality gap worsening over time? Arch Gen Psychiatry 64 : 1123-1131, 2007.
 
8) Howard R, et al : Late-onset schizophrenia and very-late-onset schizophrenia-like psychosis : an international consensus. The International Late-Onset Schizophrenia Group. Am J Psychiatry 157 : 172-178, 2000.
 
9) Vahia IV, et al : Is late-onset schizophrenia a subtype of schizophrenia? Acta Psychiatr Scand 122 : 414-426, 2010.
PubMed
10) 安田学 : 妄想性障害 (高齢者の幻覚妄想状態). 精神科治療学 32 (増刊号) : 274-277, 2017.
 
11) 濱田秀伯, 古茶大樹 : メランコリー人生後半期の妄想性障害, 弘文堂, 2008.
 
12) 古茶大樹 : 遅発緊張病について-自験例に基づく症状, 経過, 下位群, 治療の臨床精神病理学的検討-. 精神神経學雑誌 100 : 24-50, 199&
 
13) 馬場存 : 音楽幻聴. 精神科治療学 32 (増刊号) : 306-310, 2017.
 
14) 鈴木一浩, ほか : 遅発パラフレニー. 精神科 29 : 485-489, 2016.
 
P.107 掲載の参考文献
1) 西村伊三男, ほか : 高齢者のアルコール依存症. 脳とこころのプライマリケア 8 依存 (福居顕二編), p182-190, シナジー, 2011.
 
2) 白倉克之 : アルコール依存症をめぐって. アルコール・薬物関連障害の診断・治療ガイドライン (白倉克之, ほか編), p73-80, じほう, 2002.
 
3) Zimberg S : Psychological treatment of elderly alcoholics. In : Practical Approaches to Alcoholism Psychotherapy (ed by Zimberg S), p237-251, Plenum, New York, 1978.
 
4) Blow FC, Barry LB : Treatment of older adults. In : Principles of Addiction Medicine, fourth edition (ed by Ries RK, et al.), p479-492, Lippincott Williams & Wilkins, Philadelphia, 2009.
 
5) Willenbring ML, et al : Helping patients who drink too much : an evidence-based guide for primary care clinicians. Am Fam Physician 80 : 44-50, 2009.
PubMed
6) Marchall TA : Dietary Guidelines for Americans, 2010 : an update. J Am Dent Assoc 142 : 654-656, 2011.
 
7) Taj N, et al : Screening for problem drinking : does a single question work? J Fam Practi 46 : 328-335, 1998.
 
8) Naegle MA : Screening for alcohol use and misuse in older adults : using the Short Michigan Alcoholism Screening Test-Geriatric Version. Am J Nurs 108 : 50-58, 2008.
PubMed
9) Ewing JA : Detecting alcoholism. The CAGE questionnaire. JAMA 252 : 1905-1907, 1984.
PubMed
10) Adams WL, et al : Screening for problem drinking in older primary care patients. JAMA 276 : 1964-1967, 1996.
PubMed
11) 白坂知信, ほか : 高齢者のアルコール使用障害の臨床的特徴と治療. 精神科治療学 28 (増刊) : 163-166, 2013.
 
12) Dupree LW, Schonfeld L : Cognitive-behavioral and self-manegement treatment of older problem drinkers. J Ment Health Aging 4 : 215-231, 1998.
 
13) 松下幸生, ほか : 高齢アルコール依存症の診断と治療. アルコール・薬物関連障害の診断・治療ガイドライン (白倉克之, ほか編), p133-142, じほう, 2003.
 
14) Kranzler HR, et al : Medications for use in alcohol rehabilitation. In : Principles of Addiction Medicine (ed by Ries RK, et aL), p631-643, Lippincott Williams & Wilkins, Philadelphia, 2009.
 
15) Emmerson PJ, et al : Binding affinity and selectivity of opioids at mu, delta and kappa receptors in monkey brain membranes. J Pharmacol Exp Ther 271 : 1630-1637, 1994.
PubMed

X 高齢者の生活習慣病

P.115 掲載の参考文献
1) 日本高血圧学会高血圧治療ガイドライン作成委員会 : 高血圧治療ガイドライン 2014. ライフサイエンス出版, 2014.
 
2) 日本老年医学会「高齢者の生活習慣管理ガイドライン」作成ワーキング : 高齢者高血圧診療ガイドライン 2017. 日本老年医学会雑誌 54 : 1-63, 2017.
 
3) 楽木宏美, 山本浩一 : 高齢者の生活機能を考慮した高血圧管理「高齢者高血圧診療ガイドライン 2017」の活用. 日本老年医学会雑誌 54 : 1-14, 2017.
 
4) Odden MC, et al : Rethinking the association of high blood pressure with mortality in elderly adults : the impact of frailty. Arch Intern Med 172 : 1162-1168, 2012.
PubMed
5) Lewington S, et al : Age-specific relevance of usual blood pressure to vascular mortality : a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 360 : 1903-1913, 2002.
PubMed
6) Webb AJ, et al : Effects of antihypertensive-drug class on interindividual variation in blood pressure and risk of stroke : a systematic review and meta-analysis. Lancet 375 : 906-915, 2010.
PubMed
7) Ogawa H, et al : Angiotensin II receptor blocker-based therapy in Japanese elderly, high-risk, hypertensive patients. Am J Med 125 : 981-990, 2012.
PubMed
8) PROGRESS Collaborative Group : Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6, 105 individuals with previous stroke or transient ischaemic attack. Lancet 358 : 1033-1041, 2001.
PubMed
9) Turner BJ, et al : Barriers to adherence and hypertension control in a racially diverse representative sample of elderly primary care patients. Pharmacepidemiol Drug Saf 18 : 672-681, 2009.
 
10) 日本老年医学会 (編) : 健康長寿診療ハンドブック-実地医家のための老年医学のエッセンス. メジカルビュー社, 2011.
 
P.121 掲載の参考文献
1) 日本糖尿病学会 (編・著) : 糖尿病治療ガイド 2016-2017, p97-98, 2016.
 
2) Weuve J, et al : Physical activity, including walking, and cognitive function in older women. JAMA 292 : 1454-1461, 2004.
PubMed
3) Dunstan DW, et al : High-intensity resistance training improves glycemic control in older patients with type 2 diabetes. Diabetes Care 25 : 1729-1736, 2002.
PubMed
4) Morrison S, et al : Balance training reduces falls risk in older individuals with type 2 diabetes. Diabetes Care 33 : 748-750, 2010.
PubMed
5) Johnston SS, et al : Association between hypoglycaemic events and fall-related fractures in Medicarecovered patients with type 2 diabetes. Diabetes Obes Metab 14 : 634-643, 2012.
PubMed
6) Whitmer RA, et al : Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus. JAMA 301 : 1565-1572, 2009.
PubMed
7) Bonds DE, et al : The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes : retrospective epidemiological analysis of the ACCORD study. BMJ 340 : b4909, 2010.
PubMed
8) Seino Y, Yabe D : Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 : Incretin actions beyond the pancreas. J Diabetes Investig 4 : 108-130, 2013.
PubMed
9) Aviles-Olmos I, et al : Exenatide and the treatment of patients with Parkinson's disease. J Clin Invest 123 : 2730-2736, 2013.
PubMed
10) Kolosova NG, et al : [Metformin reduces the signs of sarcopenia in old OXYS rats]. Adv Gerontol 28 : 504-509, 2015.
PubMed
11) Laksmi PW, et al : Effect of Metformin on Handgrip Strength, Gait Speed, Myostatin Serum Level, and Health-related Quality of Life : A Double Blind Randomized Controlled Trial among Nondiabetic Pre-frail Elderly Patients. Acta Med Indones 49 : 118-127, 2017.
PubMed
12) Salpeter SR, et al : Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochrane Database Syst Rev : CD002967, 2010. (doi : 10.1002/14651858. CD002967)
 
13) メトホルミンの適正使用に関するRecommendation. [http://www.fa.kyorin.co.jp/jds/uploads/recommendation_metformin.pdf] (2018年6月閲覧)
 
14 Loke YK, et al : Long-term use of thiazolidinediones and fractures in type 2 diabetes : a meta-analysis. CMAJ 180 : 32-39, 2009.
PubMed
P.127 掲載の参考文献
1) Benfante R, Reed D : Is elevated serum cholesterol level a risk factor for coronary heart disease in the elderly? JAMA 263 : 393-396, 1990.
 
2) Harris T, et al : Proportional hazards analysis of risk factors for coronary heart disease in individuals aged 65 or older. The Framingham Heart Study. J Am Geriatr Soc 36 : 1023-1028, 1988.
 
3) Horiuchi H, et al : Primary cardiovascular events and serum lipid levels in elderly Japanese with hypercholesterolemia undergoing 6-year simvastatin treatment : asubanalysis of the Japan lipid intervention trial. J Am Geriatr Soc 52 : 1981-1987, 2004.
 
4) Ito H, et al : A comparison of low versus standard dose pravastatin therapy for the prevention of cardiovascular events in the elderly : the pravastatin anti-atherosclerosis trial in the elderly (PATE). J Atheroscler Thromb 8 : 33-44, 2001.
 
5) Nakaya N, et al : Low-dose pravastatin and age-related differences in risk factors for cardiovascular disease in hypercholesterolaemic Japanese : analysis of the management of elevated cholesterol in the primary prevention group of adult Japanese (MEGA study). Drugs Aging 28 : 681-692, 2011.
PubMed
6) Savarese G, et al : Benefits of statins in elderly subjects without established cardiovascular disease : a meta-analysis. J Am Coll Cardiol 62 : 2090-2099, 2013.
PubMed
7) Roberts CG, et al : Efficacy and safety of statin monotherapy in older adults : a meta-analysis. J Gerontol A Biol Sci Med Sci 62 : 879-887, 2007.
PubMed
8) Weverling-Rijnsburger AW, et al : Total cholesterol and risk of mortality in the oldest old. Lancet 350 : 1119-1123, 1997.
PubMed
9) Prospective Studies Collaboration, et al : Blood cholesterol and vascular mortality by age, sex, and blood pressure : a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet 370 : 1829-1839, 2007.
PubMed
10) Shepherd J, et al : Pravastatin in elderly individuals at risk of vascular disease (PROSPER) : a randomised controlled trial. Lancet 360 : 1623-1630, 2002.
 
11) Cholesterol Treatment Trialists' (CTT) Collaboration ; Baigent C, et al : Efficacy and safety of more intensive lowering of LDL cholesterol : a meta-analysis of data from 170, 000 participants in 26 randomised trials. Lancet 376 (9753) : 1670-1681, 2010.
PubMed
12) McGuinness B, et al : Statins for the treatment of dementia. Cochrane Database Syst Rev (7) : CD007514, 2014.
PubMed
13) White HD, et al : Frailty is associated with worse outcomes in non-ST-segment elevation acute coronary syndromes : Insights from the TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicall Y manage Acute Coronary Syndromes (TRILOGY ACS) trial. Eur Heart J Acute Cardiovasc Care 5 : 231-242, 2016.
 
14) Sergi G, et al : Pre-frailty and risk of cardiovascular disease in elderly men and women : the Pro. V. A. study. J Am Coll Cardiol 65 : 976-983, 2015.
 
15) Kutner JS, et al : Safety and benefit of discontinuing statin therapy in the setting of advanced, life-limiting illness : a randomized clinical trial. JAMA Intern Med 175 : 691-700, 2015.
PubMed
16) Sattar N, et al : Statins and risk of incident diabetes : a collaborative meta-analysis of randomised statin trials. Lancet 375 : 735-742, 2010.
PubMed
17) Roberts CG, et al : Efficacy and safety of statin monotherapy in older adults : a meta-analysis. J Gerontol A Biol Sci Med Sci 62 : 879-887, 2007.
PubMed
P.132 掲載の参考文献
1) 日本肥満学会 (編) : 肥満症診療ガイドライン 2016, ライフサイエンス出版, 2016.
 
2) Sorkin JD, et al : Longitudinal change in height of men and women : implications for interpretation of the body mass index : the Baltimore Longitudinal Study of Aging. Am J Epidemiol 150 : 969-977, 1999.
PubMed
3) Jackson AS, et al : Longitudinal changes in body composition associated with healthy ageing : men, aged 20-96 years. Br J Nutr 107 : 1085-1091, 2012.
PubMed
4) Winter JE, et al : BMI and all-cause mortality in older adults : a meta-analysis. Am J Clin Nutr 99 : 875-890, 2014.
PubMed
5) 厚生労働省 : 日本人の食事摂取基準 (2015年版) 策定検討会報告書. 平成26年3月.
 
6) Batsis JA, et al : Variation in the prevalence of sarcopenia and sarcopenic obesity in older adults associated with different research definitions : dual-energy X-ray absorptiometry data from the National Health and Nutrition Examination Survey 1999-2004. J Am Geriatr Soc 61 : 974-980, 2013.
PubMed
7) 厚生労働省 : 平成28年 国民健康・栄養調査結果の概要 [http://www.mhlw.go.jp/file/04-Houdouhappyou-10904750-Kenkoukyoku-Gantaisakukenkouzoushinka/kekkagaiyou_7.pdf]
 
8) Strandberg TE, et al : Association of midlife obesity and cardiovascular risk with old age frailty : a 26-year follow-up of initially healthy men. Int J Obes (Lond) 36 : 1153-1157, 2012.
PubMed
9) Schaap LA, et al : Adiposity, muscle mass, and muscle strength in relation to functional decline in older persons. Epidemiol Rev 35 : 51-65, 2013.
PubMed
10) Willette AA, Kapogiannis D : Does the brain shrink as the waist expands? Ageing Res Rev 20 : 86-97, 2015.
PubMed
11) Kloppenborg RP, et al : Diabetes and other vascular risk factors for dementia : which factor matters most? A systematic review. Eur J pharmacol 585 : 97-108, 2008.
PubMed
12) Loef M, Walach H : Midlife obesity and dementia : meta-analysis and adjusted forecast of dementia prevalence in the United States and China. Obesity (Silver Spring) 21 : E51-55, 2013.
PubMed
13) Lupien SJ, et al : Cortisol levels during human aging Predict hippocampal atrophy and memory deficits. Nat Neurosci 1 : 69-73, 1998.
PubMed
14) Stewart R, et al : A 32-year prospective study of change in body weight and incident dementia : the Honolulu-Asia Aging Study. Arch Neurol 62 : 55-60, 2005.
 
P.138 掲載の参考文献
1) Sorkin JD, et al : Longitudinal change in the heights of men and women : consequential effects on body mass index. Epidemiol Rev 21 : 247-260, 1999.
PubMed
2) Lee DC, et al : Physical activity and sarcopenic obesity : definition, assessment, prevalence and mechanism. Future Sci OA 2 : FSO127, 2016.
PubMed
3) Porter Starr KN, et al : Obesity and physical frailty in older adults : a scoping review of lifestyle intervention trials. J Am Med Dir Assoc 15 : 240-250, 2014.
PubMed
4) Villareal DT, et al : Weight loss, exercise, or both and physical function in obese older adults. N Engl J Med 364 : 1218-1229, 2011.
 
5) Global BMI Mortality Collaboration, et al : Body-mass index and all-cause mortality : individualparticipant-data meta-analysis of 239 prospective studies in four continents. Lancet 388 : 776-786, 2016.
PubMed
6) Fried LP, et al : Frailty in older adults : evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56 : M146-156, 2001.
PubMed
7) Xue QL, et al : Initial manifestations of frailty criteria and the development of frailty phenotype in the Women's Health and Aging Study II. J Gerontol A Biol Sci Med Sci 63 : 984-990, 2008.
 
8) 葛谷雅文 : サルコペニアの診断・病態・治療. 日本老年医学会雑誌 52 : 343-349, 2015.
 
9) Cruz-Jentoft AJ, et al : Sarcopenia : European consensus on definition and diagnosis : Report of the European Working Group on Sarcopenia in Older People. Age Ageing 39 : 412-423, 2010.
 
10) Artaza-Artabe I, et al : The relationship between nutrition and frailty : Effects of protein intake, nutritional supplementation, vitamin D and exercise on muscle metabolism in the elderly. A systematic review. Maturitas 93 : 89-99, 2016.
PubMed
11) 菱田明, 佐々木敏 (監修) : たんぱく質. 日本人の食事摂取基準 2015年度版, 初版, p88-109, 第一出版, 2014.
 
12) フレイルと栄養 (素) ・食事との関係はあるか? フレイル診療ガイド 2018年版 (荒井秀典編), ライフ・サイエンス, p28-30, 2018.
 
13) フレイルに対する栄養介入の効果はあるのか? フレイル診療ガイド 2018年版 (荒井秀典編), ライフ・サイエンス, p31-32, 2018.
 
14) 葛谷雅文 : 高齢者における栄養管理 ギアチェンジの考え方 (特集 過栄養と低栄養から読み解く高齢者の栄養管理). 日本医事新報 4797 : 41-47, 2016.
 
15) 葛谷雅文 : フレイル・要介護状態と栄養. リハ栄養からアプローチするサルコペニアバイブル (若林秀隆, 葛谷雅文編), p8-14, 日本医事新報社, 2018.
 
P.143 掲載の参考文献
1) 厚生労働省 : 健康づくりのための身体活動基準 2013. [http://www.mhlw.go.jp/stf/houdou/2r9852000002xple.html] (2018年5月閲覧)
 
2) Sone H, et al : Leisure-time physical activity is a significant predictor of stroke and total mortality in Japanese patients with type 2 diabetes : analysis from the Japan Diabetes Complications Study (JDCS). Diabetologia 56 : 1021-1030, 2013.
PubMed
3) Kodama S, et al : Association between physical activity and risk of all-cause mortality and cardiovascular disease in patients with diabetes : a meta-analysis. Diabetes Care 36 : 471-479, 2013.
PubMed
4) 日本糖尿病学会 : 運動療法. 糖尿病診療ガイドライン 2016, p67-81, 南江堂, 2016.
 
5) 日本高血圧学会高血圧治療ガイドライン作成委員会 : 生活習慣の修正. 高血圧治療ガイドライン 2014, p39-44, ライフサイエンス出版, 2014.
 
6) 厚生労働省 : 平成28年国民栄養調査の結果 [http://www.mhlw.go.jp/stf/houdou/0000177189.html] (2018年5月閲覧)
 
7) Akune T, et al : Exercise habits during middle age are associated with lower prevalence of sarcopenia : the ROAD study. Osteoporos Int 25 : 1081-1088, 2014.
PubMed
8) Lim S, et al : Sarcopenic obesity : prevalence and association with metabolic syndrome in the Korean Longitudinal Study on Health and Aging (KLoSHA). Diabetes Care 33 : 1652-1654, 2010.
PubMed
9) Newman AB, et al : Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort. J Gerontol A Biol Sci Med Sci 61 : 72-77, 2006.
 
10) Kim TN, et al : Prevalence and determinant factors of sarcopenia in patients with type 2 diabetes : the Korean Sarcopenic Obesity Study (KSOS). Diabetes Care 33 : 1497-1499, 2010.
PubMed
11) Park SW, et al : Excessive loss of skeletal muscle mass in older adults with type 2 diabetes. Diabetes Care 32 : 1993-1997, 2009.
PubMed
12) Araki A, et al : Long-term multiple risk factor interventions in Japanese elderly diabetic patients : the Japanese Elderly Diabetes Intervention Trial (J-EDIT) -study design, baseline characteristics, and effects of intervention. Geriatr Gerontol Int 12 (Suppl 1) : 7-17, 2012.
 
13) Sakurai T, et al : Risk factors for a 6-year decline in physical disability and functional limitations among elderly people with type 2 diabetes (J-EDIT). Geriatr Gerontol Int 12 (Suppl 1) : 117-126, 2012.
 
14) Iijima K, et al : Lower physical activity is a strong predictor of cardiovascular events in elderly patients with type 2 diabetes mellitus beyond traditional risk factors : the Japanese Elderly Diabetes Intervention Trial (J-EDIT). Geriatr Gerontol Int 12 (Suppl 1) : 77-87, 2012.
 
15) Marwick TH, et al : Exercise training for type 2 diabetes mellitus : impact on cardiovascular risk : a scientific statement from the American Heart Association. Circulation 119, 3244-3262, 2009.
PubMed

XI 高齢者の臓器別疾患

P.151 掲載の参考文献
1) 古江増隆, ほか : 本邦における皮膚科受診患者の多施設横断四季別全国調査. 日本皮膚科学会雑誌 119 : 1795-1809, 2009.
 
2) 片山一朗 : 加齢とTh2型免疫応答. アレルギー・免疫 21 : 231-241, 2014.
 
3) 高齢者によくみられる皮膚疾患アトラス-鑑別と治療のポイント- (横関博雄, 片山一朗編), 医薬ジャーナル, 2013.
 
P.155 掲載の参考文献
1) 種井良二 : Skin aging-乾燥肌に対するケア-. MB Derma 267 : 42-50, 2018.
Medical*Online
2) 田上八郎 : ドライスキンへのアプローチ-温故知新-. 日本化粧品学会誌 38 : 15-21, 2014.
 
3) 秋山真志 : 皮膚バリアの基礎知見Up-to-Date. 日本化粧品学会誌 38 : 22-27, 2014.
 
4) 手塚正, 山村達郎, 鈴木一成 : 老齢者下腿皮膚のTWL値の変化. 皮膚 1987 ; 29 : 276-279. 1987.
 
5) 手塚正 : 老化に伴った表皮の変化 II. 老人性乾皮症にみとめられた変化は冬期のみに認められる変化か. 皮膚 24 : 460-466, 1982.
 
6) 生駒晃彦 : かゆみ過敏 : そのメカニズムと重要性. かゆみ最前線 (宮地良樹, 生駒晃彦編), p42-45, メディカルレビュー社, 2006.
 
7) 種井良二 : 皮脂欠乏性皮膚炎. 高齢者によくみられる皮膚疾患アトラス-鑑別と治療のポイント (横関博雄, 片山一朗編), p21-24, 医薬ジャーナル社, 2013.
 
8) 波多野豊 : 皮膚バリア機能異常と炎症のクロストークの場としてのケラチノサイト. 日本皮膚科学会雑誌 124 : 321-330, 2014.
 
9) 片桐一元, ほか : 皮膚の免疫・アレルギー. Dokkyo Journal of Medical Sciences 41 : 285-293, 2014.
 
10) 高森健二 : 難治性痒みの発現メカニズム-乾燥, 透析, アトピー性皮膚炎に伴う痒みについて. 日本皮膚科学会雑誌 118 : 1931-1939, 2008.
 
11) 斎藤博久, ほか : 慢性アレルギー炎症のメカニズム-好酸球性炎症を導くメカニズムの最新知見. 実験医学 31 (増刊, 病態の理解に向かうアレルギー疾患研究 (椛島健治編)) : 20 (2706) -26 (2712), 2013.
 
12) 有馬和彦, 出原賢治 : 非免疫系細胞 (上皮細胞・線維芽細胞) によるアレルギー病態形成. 実験医学 31 (増刊, 病態の理解に向かうアレルギー疾患研究 (椛島健治編)) : 86 (2772) -92 (2778), 2013.
 
13) Darsow U, Ring J : Immunoglobulin e-mediated allergy plays a role in atopic eczema as shown in the atopy patch test. World Allergy Organ J 1 : 51-56, 2008.
 
14) Aoyama H, et al : Nummular eczema : An addition of senile xerosis and unique cutaneous reactivities to environmental aeroallergens. Dermatology (Basel) 199 : 135-139, 1999.
 
15) Tanei R, Katuoka K : Clinical analyses of atopic dermatitis in the aged. J Dermatol 35 : 562-569, 2008.
 
P.160 掲載の参考文献
1) Massry SG, et al : Secondary hyperparathyroidism in chronic renal failure. The clinical spectrum in uremia, during hemodialysis, and after renal transplantation. Arch Intern Med 124 : 431-441, 1969.
PubMed
2) 熊谷裕生 : 透析患者のかゆみに対するκ-アゴニストTRK-820. 透析治療における新しい薬物. 臨牀透析 22 : 763-772, 2006.
 
3) 松田崇史, ほか : かゆみと疾患 肝疾患-内科から. 臨牀と研究 92 : 431-434, 2015.
 
4) 川島由美 : 原発性胆汁性肝硬変におけるそう痒の原因物質に関する研究-opioid peptideの関与-. 帝京医学雑誌 28 : 89-97, 2005.
 
5) Caravati CM, et al : Cutaneous manifestations of hyperthyroidism. South Med J 62 : 1127-1130, 1969.
PubMed
6) Mela M, et al : Review article : pruritus in cholestatic and other liver diseases. Aliment Pharmacol Ther 17 : 857-870, 2003.
PubMed
7) Yamaoka H, et al : Truncal pruritus of unknown origin may be a symptom of diabetic polyneuropathy. Diabetes Care 33 : 150-155, 2010.
PubMed
8) Saini KS, et al : Polycythemia vera-associated pruritus and its management. Eur J Clin Invest 40 : 828-834, 2010.
PubMed
9) Botero F : Pruritus as a manifestation of systemic disorders. Cutis 21 : 873-880, 1978.
PubMed
10) Hiramanek N : Itch : a symptom of occult disease. Aust Fam Physician 33 : 495-499, 2004.
PubMed
11) 衛藤光 : 知っておきたい皮膚の不定愁訴. Modern Physician 35 : 939-942, 2015.
 
12) 佐藤貴浩, ほか : 汎発性皮膚癌痒症診療ガイドライン. 日本皮膚科学会雑誌 122 : 267-280, 2012.
 
P.166 掲載の参考文献
1) Hope-Simpson RE : The Nature of Herpes Zoster : A Long-term Study and A New Hypothesis. Proc R Soc Med 58 : 9-20, 1965.
 
2) Berger R, et al : Decrease of the lymphoproliferative response to varicella-zoster virus antigen in the aged. Infect Immun 32 : 24-27, 1981.
PubMed
3) Burke BL, et al : Immune responses to varicella-zoster in the aged. Arch Intern Med 142 : 291-293, 1982.
PubMed
4) Takao Y, et al : The Shozu Herpes Zoster (SHEZ) study : rationale, design, and description of a prospective cohort study. J Epidemiol 22 : 167-174, 2012.
PubMed
5) Tang H, et al : A community-based survey of varicella-zoster virus-specific immune responses in the elderly. J Clin Virol 55 : 46-50, 2012.
 
6) Okuno Y, et al : Assessment of skin test with varicella-zoster virus antigen for predicting the risk of herpes zoster. Epidemiol Infect 141 : 706-713, 2013.
PubMed
7) Asada H, et al : An inverse correlation of VZV skin-test reaction, but not antibody, with severity of herpes zoster skin symptoms and zoster-associated pain. J Dermatol Sci 69 : 243-249, 2013.
PubMed
8) 奥野良信, ほか : 帯状疱疹疫学調査 : 水痘抗原「ピケン」を用いた皮内検査による帯状疱疹および帯状疱疹後神経痛のリスク評価-コミュニティベースの前方視的コホート研究-. 臨床医薬 30 : 905-915, 2014.
 
9) Imoto K, et al : VZV skin-test reaction, but not antibody, is an important predictive factor for postherpetic neuralgia. J Dermatol Sci 79 : 235-240, 2015.
 
10) Nakamura Y, et al : Clinical and immunologic features of recurrent herpes zoster (HZ). J Am Acad Dermatol 75 : 950-956. e1, 2016.
 
11) Takahashi M, et al : Live vaccine used to prevent the spread of varicella in children in hospital. Lancet 2 : 1288-1290, 1974.
PubMed
12) Takahashi M, et al : Enhancement of immunity against VZV by giving live varicella vaccine to the elderly assessed by VZV skin test and IAHA, gpELISA antibody assay. Vaccine 21 : 3845-3853, 2003.
 
13) Oxman MN, et al : A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. N Engl J Med 352 : 2271-2284, 2005.
PubMed
14) Lal H, et al : Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults. N Engl J Med 372 : 2087-2096, 2015.
PubMed
15) Cunningham AL, et al : Efficacy of the Herpes Zoster Subunit Vaccine in Adults 70 Years of Age or Older. N Engl J Med 375 : 1019-1032, 2016.
 
16) Cook SJ, Flaherty DK : Review of the Persistence of Herpes Zoster Vaccine Efficacy in Clinical Trials. Clin Ther 37 : 2388-2397, 2015.
PubMed
17) Chono K, et al : ASP2151, a novel helicase-primase inhibitor, possesses antiviral activity against varicella-zoster virus and herpes simplex virus types 1 and 2. J Antimicrob Chemother 65 : 1733-1741, 2010.
PubMed
P.172 掲載の参考文献
1) Sei Y : 2006年次皮膚真菌症疫学調査報告. Med Mycol J 53 : 185-192, 2012.
 
2) 仲弥, ほか : 足白癬・爪白癬の実態と潜在罹患率の大規模疫学調査 (Foot Check 2007). 日本臨床皮膚科医会雑誌 26 : 27-36, 2009.
 
3) 日本医真菌学会疫学調査委員会 : 1997年次皮膚真菌症疫学調査成績. 日本医真菌学会雑誌 42 : 11-18, 2001.
 
4) 楠原正洋 : スポロトリコーシスの疫学. 皮膚科臨床アセット4皮膚真菌症を究める (古江増隆, 望月隆編集), 184-186, 中山書店, 2011.
 
5) 菊地夕子, ほか : 上腕に小型の皮疹を生じたFonsecaea pedrosoiによるクロモミコーシスの1例 : 症例報告及び本邦における黒色真菌感染症報告例のまとめ. 日本医真菌学会雑誌 48 : 85-89, 2007.
 
6) Zeng JS, et al : Spectrum of clinically relevant Exophiala species in the United States. J Clin Microbiol 45 : 3713-3720, 2007.
PubMed
7) Sakata Y, et al : Case of cutaneous phaeohyphomycosis caused by Phaeoacremonium sp. in a renal transplant recipient. J Dermatol 42 : 263-266, 2015.
 
8) 牛上敢, ほか : 肝不全に合併したPhaeoacremonium parasiticumによる黒色菌糸症の1例. 皮膚の科学 (印刷中)
 
9) 竹内明子, ほか : 落葉状天疱瘡に対する免疫抑制療法中に生じたScedosporium apiospermumによる深在性皮膚真菌症の1例. 日本皮膚科学会雑誌 124 : 1135-1140, 2014.
 
10) Sakata Y, et al : A Case of Cutaneous Mycosis caused by Scedosporium dehoogii on an immunocompromised patient. Mycopathologia 183 : 465-470, 2018.
 
11) Watanabe S, et al : Case of mycotic cyst caused by Scedosporium apiospermum developed liver dysfunction following administration of voriconazole. J Dermatol 44 : e296-e297, 2017.
PubMed
12) 渡辺晋一, ほか : 日本皮膚科学会ガイドライン 皮膚真菌症診断・治療ガイドライン. 日本皮膚科学会雑誌 119 : 851-86, 2009.
 
13) 南條育子, ほか : 各種外用抗真菌薬のin vitro抗真菌活性の測定. 日本皮膚科学会雑誌 117 : 149-152, 2007.
 
14) Wood N : Voriconazoleの薬物動態. 日本化学療法学会雑誌 53 (S-2) : 16-23, 2005.
 
15) 中嶋弘 : いわゆる寝たきり老人 (高齢者) の爪白癬および手足白癬の実態とその特徴. 皮膚病診療 33 : 320-324, 2011.
 
16) 清佳浩 : 2011年次皮膚真菌症疫学調査報告. Med Mycol J 56 : J129-J135, 2015.
 
17) Watanabe S, et al : High prevalence of superficial white onychomycosis by Trichophyton interdigitale in a Japanese nursing home with a geriatric hospital. Mycoses 60 : 634-637, 2017.
 
18) 藤田繁, ほか : 新潟県の一特別養護老人ホームにおけるMicrosporum canisによる頭部白癬および体部白癬の集団発生. 臨床皮膚科 46 : 233-237, 1992.
 
19) 角谷廣幸, ほか : 老人ホーム入居者および職員にみられたTrichophyton violaceum感染症. 日本医真菌学会雑誌 46 : 279-284, 2005.
 
P.177 掲載の参考文献
1) 厚生労働省. 平成28年国民生活基礎調査の概況. [http://www.mhlw.go.jp/toukei/saikin/hw/k-tyosa/k-tyosa16/index.html] (2018年5月閲覧)
 
2) Stuck AE, et al : Risk factors for functional status decline in community-living elderly people : a systematic literature review. Soc Sci & Med, 48 : 445-469, 1999.
PubMed
3) West SK, et al : How does visual impairment affect performance on tasks of everyday life? The SEE Project. Salisbury Eye Evaluation. Arch Ophthalmol 120 : 774-780, 2002.
PubMed
4) Mine M, et al : Association of Visual Acuity and Cognitive Impairment in Older Individuals : Fujiwara-kyo Eye Study. Biores Open Access 5 : 228-234, 2016.
PubMed
5) Miyata K, et al : Effect of cataract surgery on cognitive function in elderly : Results of Fujiwara-kyo Eye Study. PLoS ONE 13 : e0192677, 2018.
PubMed
6) Roberts CB, et al : Economic cost of visual impairment in Japan. Arch Ophthalmol 128 : 766-771, 2010.
PubMed
7) Yamada M, et al : Prevalence of visual impairment in the adult Japanese population by cause and severity and future projections. Ophthalmic Epidemiol 17 : 50-57, 2010.
PubMed
8) Iwase A, et al : Prevalence and causes of low vision and blindness in a Japanese adu1t population : the Tajimi Study. Ophthalmology 113 : 1354-1362, 2006,
 
9) 森實祐基, ほか : 全都道府県を対象にした視覚障がい認定の疫学調査. 第121回日本眼科学会総会, 2017.
 
10) 厚生労働科学研究費補助金障害者対策総合研究事業「成人を対象とした眼検診プログラムの臨床疫学, 医療経済学的評価」平成22年度-24年度総合研究報告書 (研究代表者 : 山田昌和), 平成25年, 2013.
 
P.182 掲載の参考文献
1) 藤沢来人, ほか : 地域住人を対象とした白内障の疫学的調査 (第2報). 日本眼科紀要 40 : 615-620, 1989.
 
2) Neale RE, et al : Sun exposure as a risk factor for nuclear cataract. Epidemiology 14 : 707-712, 2003.
PubMed
3) Kawakami Y, et al : Characteristics and frequency of cortical cataracts at an early stage (Reykjavik Eye Study in Iceland). Klin Monbl Augenheilkd 218 : 78-84, 2001. [German]
PubMed
4) Christen WG, et al : A prospective study of cigarette smoking and risk of cataract in men. JAMA 268 : 989-993, 1992.
PubMed
5) Christen WG, et al : Smoking cessation and risk of age-related cataract in men. JAMA 284 : 713-716, 2000.
PubMed
6) Harding JJ, et al : Diabetes, glaucoma, sex, and cataract : analysis of combined data from two case control studies. Br J Ophthalmol 77 : 2-6, 1993.
PubMed
7) Klein BE, et al : Prevalence of cataracts in a population-based study of persons with diabetes mellitus. Ophthalmology 92 : 1191-1196, 1985.
 
8) Leske MC, et al : Diabetes, hypertension, and central obesity as cataract risk factors in a black population. The Barbados Eye Study. Ophthalmology 106 : 35-41, l999.
 
9) Kociecki J, et al : [Evaluation of effectiveness of Catalin eyedrops in patients with presenile and senile cataract]. Klin Oczna 106 : 778-782, 2004. [Polish]
PubMed
10) Milton RC, et al : Centrum use and progression of age-related cataract in the Age-Related Eye Disease Study : apropensity score approach. AREDS report No. 21. Ophthalmology 113 : 1264-1270, 2006.
PubMed
11) Age-Related Eye Disease Study 2 (AREDS2) Research Group, et al : Lutein/zeaxanthin for the treatment of age-related cataract : AREDS2 randomized trial report no. 4. JAMA Ophthalmol 131 : 843-850, 2013.
 
12) Inoue T, et al : Incidence of endophthalmitis and the perioperative practices of cataract surgery in Japan : Japanese Prospective Multicenter Study for Postoperative Endophthalmitis after Cataract Surgery. Jpn J Ophthalmol 62 : 24-30, 2018.
PubMed
P.186 掲載の参考文献
1) Iwase A, et al : The prevalence of primary open-angle glaucoma in Japanese : the Tajimi Study. Ophthalmology 111 : 1641-1648, 2004
PubMed
2) 日本緑内障学会 : 緑内障診療ガイドライン. 日本眼科学会雑誌 107 : 125-127, 2003.
 
3) 日本緑内障学会 : 緑内障診療ガイドライン (第4版). 日本眼科学会雑誌 122 : 5-53, 2018.
 
4) Medeiros FA, et al : The structure and function relationship in glaucoma : implications for detection of progression and measurement of rates of change. Invest Ophthalmol Vis Sci 53 : 6939-6946, 2012.
PubMed
5) Weinreb RN, et al : Risk assessment in the management of patients with ocular hypertension. Am J Ophthalmol 138 : 458-467, 2004.
PubMed
6) Nakano M, et al : Three susceptible loci associated with primary open-angle glaucoma identified by genome-wide association study in a Japanese population. Proc Natl Acad Sci USA 106 : 12838-12842, 2009.
 
7) Burdon KP, et al : Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1. Nat Genet 43 : 574-578, 2011.
PubMed
8) Nakano M, et al : Common variants in CDKN2B-AS1 associated with optic-nerve vulnerability of glaucoma identified by genome-wide association studies in Japanese. PLoS ONE 7 : e33389, 2012.
PubMed
9) Garway-Heath DF, et al : Latanoprost for open-angle glaucoma (UKGTS) : a randomised, multicentre, placebo-controlled trial. Lancet 385 : 1295-1304, 2015.
PubMed
10) Krupin T, et al : A randomized trial of brimonidine versus timolol in preserving visual function : results from the Low-Pressure Glaucoma Treatment Study. Am J Ophthalmol 151 : 671-681, 2011.
PubMed
11) Tanihara H, et al : Phase 2 randomized clinical study of a Rho kinase inhibitor, K-115, in primary openangle glaucoma and ocular hypertension. Am J Ophthalmol 156 : 731-736, 2013.
PubMed
12) 山本哲也 : 緑内障ドラッグデリバリー研究の現況と将来. あたらしい眼科 35 : 19-25, 2018.
Medical*Online
13) 日本緑内障学会 : 緑内障診療ガイドライン (第3版) 補遺 緑内障チューブシャント手術に関するガイドライン. 日本眼科学会雑誌 116 : 388-393, 2012.
 
14) 山本哲也 : MIGS-総論的解説と臨床上の位置. あたらしい眼科 34 : 3-7, 2017.
Medical*Online
15) 日本緑内障学会 : 白内障手術併用眼内ドレーン使用要件等基準. 日本眼科学会雑誌 120 : 494-497, 2016.
 
P.191 掲載の参考文献
1) Coscas G, et al : Comparison of exudative age-related macular degeneration subtypes in Japanese and French Patients : multicenter diagnosis with multimodal imaging. Arn J Ophthalmol 158 : 309-318. e2, 2014.
 
2) Miyake M, et al : Pachychoroid neovasculopathy and age-related macular degeneration. Sci Rep 5 : 16204, 2015.
PubMed
3) Hageman GS, et al : A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci USA 102 : 7227-7232, 2005.
PubMed
4) Klein RJ, et al : Complement factor H polymorphism in age-related macular degeneration. Science 308 : 385-389, 2005.
PubMed
5) Dewan A, et al : HTRA1 promoter polymorphism in wet age-related macular degeneration. Science 314 : 989-992, 2006.
PubMed
6) 高橋寛二, ほか : 加齢黄斑変性の治療指針. 日本眼科学会雑誌 116 : 1150-1155, 2012.
 
7) Kuroda Y, et al : Retinal Pigment Epithelial Atrophy in Neovascular Age-Related Macular Degeneration After Ranibizumab Treatment. Am J Ophthalmol 161 : 94-103. e1, 2016.
 
P.196 掲載の参考文献
1) Miyazaki M, et al : Comparison of diagnostic methods for diabetes mellitus based on prevalence of retinopathy in a Japanese population : the Hisayama Study. Diabetologia 47 : 1411-1415, 2004.
 
2) Tyrberg M, et al : Retinopathy in subjects with impaired fasting glucose : the NANSY-Eye baseline report. Diabetes Obes Metab 10 : 646-651, 2008.
PubMed
3) Yoshida S, et al : Increased vitreous concentrations of MCP-1 and IL-6 after vitrectomy in patients with proliferative diabetic retinopathy : Possible association with postoperative macular oedema. Br J Ophthalmol 99 : 960-966, 2015.
PubMed
4) Aiello LP, et al : Vascular endothelial growth factor in ocular flしlid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 331 : 1480-1487, 1994.
 
5) Kato S, et al : Retinopathy in older patients with diabetes mellitus. Diabetes Res Clin Pract 58 : 187-192, 2002.
PubMed
6) Shimura M, et al : Posterior sub-Tenon's capsule injection of triamcinolone acetonide prevents panretinal photocoagulation-induced visual dysfunction in patients with severe diabetic retinopathy and good vision. Ophthalmology 113 : 381-387, 2006.
PubMed
7) 岩田健作, ほか : 増殖糖尿病網膜症に対する小切開硝子体手術の視力予後因子の検討. 臨床眼科. (印刷中)
 
8) 岩田健作, ほか : 眼内レンズの有無によるシリコーンオイルタンポナーデ時の眼圧, 角膜内皮への影響. 日本眼科学会雑誌 117 : 95-101, 2013.
Medical*Online
9) Mitchell P, et al : The RESTORE study : ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema. Ophthalmology 118 : 615-625, 2011.
 
10) Brown GC : Vision and quality-of-life. Trans Am Ophthalmol Soc 97 : 473-511, 1999.
 
P.202 掲載の参考文献
1) The epidemiology of dry eye disease : report of the Epidemiology Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf 5 : 93-107, 2007.
 
2) Uchino M, et al : The features of dry eye disease in a Japanese elderly population. Optom Vis Sci 83 : 797-802, 2006.
 
3) Tsubota K, et al : Conjunctival epithelium expression of HLA-DR in dry eye patients. Ophthalmologica 213 : 16-19, 1999.
PubMed
4) Stern ME, et al : The pathology of dry eye : the interaction between the ocular surface and lacrimal glands. Cornea 17 : 584-589, 1998.
 
5) Obata H, et al : Histopathologic study of human lacrimal gland. Statistical analysis with special reference to aging. Ophthalmology 102 : 678-686, 1995.
 
6) Mathers WD, et al : Tear film changes associated with normal aging. Cornea 15 : 229-234, 1996.
PubMed
7) Sullivan BD, et al : Influence of aging on the polar and neutral lipid profiles in human meibomian gland secretions. Arch Ophthalmol 124 : 1286-1292, 2006.
PubMed
8) Vu CHV, et al : Influence of Meibomian Gland Dysfunction and Friction-Related Disease on the Severity of Dry Eye. Ophthalmology, 2018. [Epub ahead of print]
 
9) Offord EA, et al : Immortalized human corneal epithelial cells for ocular toxicity and inflammation studies. Invest Ophthalmol Vis Sci 40 : 1091-1101, 1999.
PubMed
10) Kawashima M, et al : Calorie restriction : A new therapeutic intervention for age-related dry eye disease in rats. Biochem Biophys Res Commun 397 : 724-728, 2010.
PubMed
11) Kojima T, et al : Age-related dysfunction of the lacrimal gland and oxidative stress : evidence from the Cu, Zn-superoxide dismutase-1 (Sodl) knockout mice. Am J Pathol 180 : 1879-1896, 2012.
 
12) Wakamatsu TH, et al : Evaluation of lipid oxidative stress status in Sjogren syndrome patients. Invest Ophthalmol Vis Sci 54 : 201-210, 2013.
PubMed
13) Dry Eye Assessment and Management Study Research Group, et al : n-3 Fatty Acid Supplementation for the Treatment of Dry Eye Disease. N Engl J Med 378 : 1681-1690, 2018.
 
14) Kawashima M, et al : Decreased tear volume in patients with metabolic syndrome : the Osaka study. Br J Ophthalmol 98 : 418-420, 2014.
PubMed
15) Kawashima M, et al : Impact of lifestyle intervention on dry eye disease in office workers : a randomized controlled trial. J Occup Health, 2018. [Epub ahead of print]
 
P.206 掲載の参考文献
1) 大前由紀雄, ほか : 超高齢者の嚥下機能-加齢に伴う嚥下機能の変化. 日本気管食道科学会会報 54 : 1-7, 2003.
Medical*Online
2) Wakabayashi H, et al : Skeletal muscle mass is associated with severe dysphagia in cancer patients. J Cachexia Sarcopenia Muscle 6 : 351-357, 2015.
PubMed
3) Maeda K, Akagi J : Decreased tongue pressure is associated with sarcopenia and sarcopenic dysphagia in the elderly. Dysphagia 30 : 80-87, 2015.
PubMed
4) Joglekar S, et al : The impact of sarcopenia on survival and complications in surgical oncology : A review of the current literature. J Surg Oncol 112 : 503-509, 2015.
PubMed
5) Maeda K, et al : Decreased Skeletal Muscle Mass and Risk Factors of Sarcopenic Dysphagia : A Prospective Observational Cohort Study. J Gerontol A Biol Sci Med Sci 72 : 1290-1294, 2017.
PubMed
6) 厚生労働省 : 平成27年人口動態統計月報年計 (概数) の概況. [http://www.mhlw.go.jp/toukei/saikin/hw/jinkou/geppo/nengai15/index.html]
 
7) 花井信広, ほか : 高齢者頭頸部癌手術の治療成績と術後合併症. 頭頸部外科 23 : 285-293, 2013.
 
8) 別府武, ほか : 後期高齢者頭頸部癌に対する外科治療, 頭頸部癌 42 : 382-389, 2016.
 
9) 菅澤正 : 高齢者の頭頸部癌治療. 日本気管食道科学会会報 65 : 388-394, 2014.
Medical*Online
10) 岡野晋 : 高齢者口腔癌に対するがん薬物療法. 日本口腔腫瘍学会誌 29 : 182-188, 2017.
Medical*Online
11) 浅田行紀 : 高齢者の化学療法. MB ENTONI 190 : 32-40, 2016.
Medical*Online
12) JCOG高齢者研究ポリシー. [http://www.jcog.jp/basic/org/committee/gsc.html1]
 
13) 花井信広 : 認知症・せん妄への対応. 耳鼻咽喉科・頭頸部外科 89 : 602-608, 2017.
 
14) 藤本保志 : 高齢者頭頸部癌患者と嚥下障害. MB ENTONI 196 : 25-30, 2016.
Medical*Online
15) 山崎知子 : 高齢者への化学放射線療法. 耳鼻咽喉科・頭頸部外科 89 : 570-576, 2017.
 
P.211 掲載の参考文献
1) 内田育恵, ほか : ミニシンポジウム「超高齢社会における耳科診療update」疫学的視点-近年の高齢者の難聴・認知機能・社会的孤立などの現況. Otology Japan 26 : 155-160, 2016.
 
2) Uchida Y, et al : Prevalence of self-perceived auditory problems and their relation to audiometric thresholds in a middle-aged to elderly population. Acta Otolaryngol 123 : 618-626, 2003.
 
3) 内田育恵, ほか : 補聴器所有に関連する要因および聴力の自他覚評価についての検討. 日本耳鼻咽喉科学会会報 111 : 405-411, 2008.
Medical*Online
4) Nishimura T, et al : Hearing aids reduce overestimation in pre-fitting self-assessment. Auris Nasus Larynx 39 : 156-162, 2012.
PubMed
5) Gates GA, et al : Central auditory dysfunction as a harbinger of Alzheimer dementia. Arch Otolaryngol Head Neck Surg 137 : 390-395, 2011.
PubMed
6) 小寺一興, ほか : 補聴器適合検査の指針 (2010) について. Audiology Japan 53 : 708-726, 2010.
Medical*Online
P.215 掲載の参考文献
1) Horn KL, et al : Functional use of the Nucleus 22-channel cochlear implant in the elderly. Laryngoscope 101 : 284-288, 1991.
PubMed
2) Djalilian HR, et al : Cochlear implantation in the elderly : results and quality of life assesement. Ann Otol Rhinol Laryngol 111 : 890-895, 2002.
 
3) Chatelin V, et al : Cochlear implant outcomes in the elderly. Otol Neurotol 25 : 298-301, 2004.
PubMed
4) Vermeire K, et al : Quality-of-Life benefit from cochlear implantation in the elderly. Otol Neurotol 26 : 188-195, 2005.
PubMed
5) Haensel J, et al : Speech perception in elderly patients following cochlear implantation. Acta Otolaryngol 125 : 1272-1276, 2005.
PubMed
6) Hay-McCutcheon MJ, et al : Audiovisual speech perception in elderly cochlear implant recipients. Laryngoscope 115 : 1887-1894, 2005.
PubMed
7) Leung J, et al : Predictive models for cochlear implantation in elderly candidates. Arch Otolaryngol Head Neck Surg 131 : 1049-1054, 2005.
PubMed
8) Cohen NL, et al : Complications of cochlear implant surgery in adults and children. Ann Otol Rhinol Laryngol 100 : 708-711, 1991.
PubMed
9) Buchman CA, Hoffman RA : Cochlear implants in the geriatric population : benefits outweigh risks. Ear Nose Throat J 78 : 489-494, 1999.
 
10) Almario JE, et al : A new minimal approach in cochlear implant surgery : the Colombian experience. Otolaryngol Head Neck Surg 133 : 147-149, 2005.
PubMed
11) Dalchow CV, Werner JA : A new instrument for minimal access surgery in cochlear implantation. Otol Neurotol 26 : 678-679, 2005.
PubMed
P.224 掲載の参考文献
1) 厚生労働省 : 平成28年歯科疾患実態調査の概要, p22, 2017.
 
2) Castrejon-Perez RC, et al : Oral Disease and 3-Year Incidence of Frailty in Mexican Older Adults. J Gerontol A Biol Sci Med Sci 72 : 951-957, 2017.
PubMed
3) Watanabe Y, et al : Relationship Between Frailty and Oral Function in Community-Dwelling Elderly Adults. J Am Geriatr Soc 65 : 66-76, 2017.
PubMed
4) Demmer RT, et al : The influence of type 1 and type 2 diabetes on periodontal disease progression : prospective results from the Study of Health in Pomerania (SHIP). Diabetes Care 35 : 2036-2042, 2012.
 
5) Demmer RT, et al : Periodontal status and A1C change : longitudinal results from the study of health in Pomerania (SHIP). Diabetes Care 33 : 1037-1043, 2010.
 
6) Lazar MA : How obesity causes diabetes : not a tall tale. Science 307 : 373-375, 2005.
 
7) Nishimura F, et al : Porphyromonas gingivalis infection is associated with elevated C-reactive protein in nonobese Japanese type 2 diabetic subjects. Diabetes Care 25 : 1888, 2002.
PubMed
8) Iwamoto Y, et al : The effect of antimicrobial periodontal treatment on circulating tumor necrosis factor-alpha and glycated hemoglobin level in patients with type 2 diabetes. J Periodontol 72 : 774-778, 2001.
PubMed
9) Iwamoto Y, et al : Antimicrobial periodontal treatment decreases serum C-reactive protein, tumor necrosis factor-alpha, but not adiponectin levels in patients with chronic periodontitis. J Periodontol 74 : 1231-1236, 2003.
 
10) Munenaga Y, et al : Improvement of glycated hemoglobin in Japanese subjects with type 2 diabetes by resolution of periodontal inflammation using adjunct topical antibiotics : results from the Hiroshima Study. Diabetes Res Clin Pract 100 : 53-60, 2013.
PubMed
11) Engebretson SP, et al : The effect of nonsurgical periodontal therapy on hemoglobin A1c levels in persons with type 2 diabetes and chronic periodontitis : a randomized clinical trial. JAMA 310 : 2523-2532, 2013.
 
12) Geisinger ML, et al : Systemic Inflammatory Biomarkers and Their Association With Periodontal and Diabetes-Related Factors in the Diabetes and Periodontal Therapy Trial, A Randomized Controlled Trial. J Periodontol 87 : 900-913, 2016.
 
13) 葛谷雅文 : 高齢者の栄養管理-ギアチェンジの考え方. 日本医事新報 4797 : 41-47, 2016.
 
14) Zhu Y, et al : Increasing the number of masticatory cycles is associated with reduced appetite and altered postprandial plasma concentrations of gut hormones, insulin and glucose. Br J Nutr 110 : 384-390, 2013.
PubMed
15) Zhu Y, et al : Increased number of chews during a fixed-amount meal suppresses postprandial appetite and modulates glycemic response in older males. Physiol Behav 133 : 136-140, 2014.
PubMed
P.229 掲載の参考文献
1) Sato Y, et al : An evaluation of chewing function of complete denture wearers. J Prosthet Dent 62 : 50-53, 1989.
PubMed
2) Manly RS, Braley LC : Masticatory performance and efficiency. J Dent Res 29 : 448-462, 1950.
PubMed
3) Ikebe K et al : Reproducibility and accuracy in measuring masticatory performance using test gummy jelly. Prosthodont Res Prac 4 : 9-15, 2005.
 
4) Tarkowska A, et al : Assessment of masticatory performance by means of a color-changeable chewing gum. J Prosthodont Res 61 : 9-19, 2017.
PubMed
5) Shiga H, et al : Relationship between masticatory performance using a gummy jelly and food intake ability in Japanese complete denture wearers. Odontology 103 : 356-359, 2015.
PubMed
6) Nokubi T, et al : Validity and reliability of a visual scoring method for masticatory ability using test gummy jelly. Gerodontology 30 : 76-82, 2013.
PubMed
7) Ikebe K, et al : Association of masticatory performance with age, gender, number of teeth, occlusal force and salivary flow in Japanese older adults : is ageing a risk factor for masticatory dysfunction? Arch Oral Biol 56 : 991-996, 2011.
PubMed
8) Kosaka T, et al : A multifactorial model of masticatory performance : the Suita study. J Oral Rehabil 43 : 340-347, 2016.
PubMed
9) Kosaka T, et al : The effect of periodontal status and occlusal support on masticatory performance : the Suita study. J Clin Periodontol 41 : 497-503, 2014.
PubMed
10) Kobayashi Y, et al : Differences in masticatory function of subjects with different closing Path. J Prosthodont Res 53 : 142-145, 2009.
 
11) Yamada A, et al : Association between tongue and lip functions and masticatory performance in young dentate adults. J Oral Rehabil 42 : 833-839, 2015.
PubMed
12) Ikebe K, et al : Association between oral stereognostic ability and masticatory performance in aged complete denture wearers. Int J Prosthodont 20 : 245-250, 2007.
PubMed
13) Kikui M, et al : Relationship between metabolic syndrome and objective masticatory performance in a Japanese general population : The Suita study. J Dent 56 : 53-57, 2017.
 
14) Tanaka T et al : Oral Frailty as a Risk Factor for Physical Frailty and Mortality in Community-Dwelling Elderly. J Gerontol A Biol Sci Med Sci, 2017. (doi : 10.1093/gerona/glx225)
 
15) 水口俊介, ほか : 高齢期における口腔機能低下-学会見解論文 2016年度版-. 老年歯学 31 : 81-99, 2016.
 
P.234 掲載の参考文献
1) 若杉葉子, ほか : 絶食のまま経過している胃瘻患者の嚥下機能評価. 老年歯科医学 28 : 227-228, 2013. (会議録)
 
2) 戸原玄 : 在宅療養中の胃瘻患者に対する摂食・嚥下リハビリテーションに関する総合的研究. 厚生労働科学研究費補助金長寿科学総合研究事業, 平成23年度～平成25年度総合研究報告書, 平成26年3月 (研究代表者近藤和泉).
 
P.239 掲載の参考文献
1) Kosaka T, et al : A multifactorial model of masticatory performance : the Suita study. J Oral Rehabil 43 : 340-347, 2016.
PubMed
2) Yoshida M, et al : Immediate effect of denture wearing on swallowing in rehabilitation hospital inpatients. J Am Geriatr Soc 61 : 655-657, 2013.
PubMed
P.245 掲載の参考文献
1) 厚生省 : 成人歯科保健対策検討会中間報告, 1989年.
 
2) 第259回中央社会保険医療協議会総会 (11月22日開催) 厚労省配布資料「歯科医療 (その2) 」p3-4 「歯科医療の需要の将来予想 (イメージ) 」, 2013.
 
3) 平成25年度厚生労働省老人保健健康増進等事業「食 (栄養) および口腔機能に着目した加齢症候群の概念の確立と介護予防 (虚弱化予防) から要介護状態に至る口腔ケアの包括的対策の構築に関する研究」報告書, 国立長寿医療研究センター, 2014.
 
4) 神奈川県健康増進課/一般社団法人神奈川県歯科医師会 : オーラルフレイルハンドブック, 2018. [http://www.pref.kanagawa.jp/docs/cz6/cnt/s001/documents/kanagawahandbook.pdf] (2018年7月閲覧)
 
5) Tanaka T, et al : Oral Frailty as a Risk Factor for Physical Frailty and Mortality in Community-Dwelling Elderly. J Gerontol A Biol Sci Med Sci, 2017. [Epub ahead of print]
 
6) 口腔機能低下症に関する基本的な考え方. 日本歯科医学会, 平成30年3月.
 
7) 平野浩彦, ほか (編) : 実践! オーラルフレイル対応マニュアル, 東京都福祉保健財団, 2016.
 
8) 東京都健康長寿医療センター研究所健康長寿新ガイドライン策定委員会 (監修) : 健康長寿新ガイドラインシリーズ : お口の健康 かむ力と飲み込む力の強化法. 社会保険出版, 2017.
 
P.250 掲載の参考文献
1) 厚生労働省 : 平成30年度診療報酬改定の概要 歯科-厚生労働省. [http://wwwmhlw.go.jp/file/06-Seisakujouhou-12400000-Hokenkyoku/0000203139.]
 
2) Aoyama T, et al : Double-blind, placebo-controlled, randomized phase II study of TJ-14 (hangeshashinto) for gastric cancer chemotherapy-induced oral mucositis. Cancer Chemother Pharmacol 73 : 1047-1054, 2014.
PubMed
3) Katsura K, et al : A study on a dental device for the prevention of mucosal dose enhancement caused by backscatter radiation from dental alloy during external beam radiotherapy. J Radiat Res 57 : 709-713, 2016.
 
4) Matsuo K, et al : Associations between oral complications and days to death in palliative care Patients. Support Care Cancer 24 : 157-161, 2016.
PubMed
5) Ohno T, et al : Change in Food Intake Status of Terminally Ill Cancer Patients during Last Two Weeks of Life : A Continuous Observation. J Palliat Med 19 : 879-882, 2016.
 
6) Yoneyama T, et al : Oral care and pneumonia. Lancet 354 : 515, 1999.
PubMed
7) Scannapieco FA, et al : Associations between oral conditions and respiratory disease in a national sample survey population. Ann Periodontol 3 : 251-256, 1998.
 
8) Akutsu Y, et al : Pre-operative dental brushing can reduce the risk of postoperative pneumonia in esophageal cancer patients. Surgery 147 : 497-502, 2010.
PubMed
9) Spreadborough P, et al : A systematic review and meta-analysis of perioperative oral decontamination in patients undergoing major elective surgery. Perioper Med (Lond) 5 : 6, 2016.
PubMed
10) Pedersen PU, et al : The effectiveness of systematic perioperative oral hygiene in reduction of postoperative respiratory tract infections after elective thoracic surgery in adults : a systematic review. JBI Database System Rev Implement Rep 14 : 140-173, 2016.
PubMed
11) Humphrey LL, et al : Periodontal disease and coronary heart disease incidence : a systematic review and meta-analysis. J Gen Intern Med 23 : 2079-2086, 2008.
PubMed
12) Sfyroeras GS, et al : Association between periodontal disease and stroke. J Vasc Surg 55 : 1178-1184, 2012.
PubMed
13) Michaud DS, et al : Periodontal disease, tooth loss, and cancer risk in male health professionals : a prospective cohort study. Lancet Oncol 9 : 550-558, 2008.
PubMed
P.254 掲載の参考文献
1) Gillooly M, Lamb D : Airspace size in lungs of lifelong non-smokers : effect of age and sex. Thorax 48 : 39-43, 1993.
PubMed
2) Copley SJ, et al : Effect of aging on lung structure in vivo : assessment with densitometric and fractal analysis of high-resolution computed tomography data. J Thorac Imaging 27 : 366-371, 2012.
 
3) 長瀬隆英 : 加齢と呼吸機能. 臨床呼吸機能検査, 第7版 (日本呼吸器学会肺生理専門委員会編), p. 289-292, メディカルレビュー社, 2008.
 
4) Skloot GS : The Effects of Aging on Lung Structure and Function. Clin Geriatr Med 33 : 447-457, 2017.
PubMed
5) Sclauser Pessoa IM, et al : Reference values for maximal inspiratory pressure : a systematic review. Can Respir J 21 : 43-50, 2014.
PubMed
6) 日本呼吸器学会肺生理専門委員会報告 : 日本人のスパイログラムと動脈血ガス分圧基準値. 日本呼吸器学会雑誌 39 : 1-17, 2001
 
7) 日本呼吸器学会肺生理専門委員会 (編) : 呼吸機能検査ガイドライン-スパイロメトリー, フローボリューム曲線, 肺拡散能力-. メディカルレビュー社, 2004.
 
8) Casanova C, et al : The 6-min walk distance in healthy subjects : reference standards from seven countries. Eur Respir J 37 : 150-156, 2011.
PubMed
9) Budinger GRS, et al : The Intersection of Aging Biology and the Pathobiology of Lung Diseases : A Joint NHLBI/NIA WorkshoP. J Gerontol A Biol Sci Med Sci 72 : 1492-1500, 2017.
PubMed
10) Puchelle E, et al : Influence of age on bronchial mucociliary transport. Scand J Respir Dis 60 : 307-313, 1979.
PubMed
11) Svartengren M, et al : Long-term clearance from small airways decreases with age. Eur Respir J 26 : 609-615, 2005.
PubMed
12) Lombardi I Jr, et al : Evaluation of pulmonary function and quality of life in women with osteoporosis. Osteoporosi Int 16 : 1247-1253, 2005.
 
13) Yamaguchi Y, et al : Pulmonary features associated with being underweight in older men. J Am Geriatr Soc 59 : 1558-1560, 2011.
 
14) Fukuchi Y, et al : COPD in Japan : the Nippon COPD Epidemiology study. Respirology 9 : 458-465, 2004.
PubMed
15) Lange P, et al : Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease. N Engl J Med 373 : 111-122, 2015.
PubMed
P.259 掲載の参考文献
1) Wechsler ME : Getting control of uncontrolled asthma. Am J Med 127 : 1049-1059, 2014.
PubMed
2) Lange P, et al : A 15-year follow-up study of ventilatory function in adults with asthma. N Engl J Med 339 : 1194-1200, 1998.
 
3) Inoue H, et al : Pathophysiological characteristics of asthma in the elderly : a comprehensive study. Ann Allergy Asthma Immunol 113 : 527-533, 2014.
PubMed
4) Wieshammer S, Dreyhaupt J : Dry powder inhalers : which factors determine the frequency of handling errors? Respiration 75 : 18-25, 2008.
PubMed
5) Al-Alawi M, et al : Advances in the diagnosis and management of asthma in older adults. Am J Med 127 : 370-378, 2014.
PubMed
6) Chotirmall SH, Burke CM : Aging and the microbiome : implications for asthma in the elderly? Expert Rev Respir Med 9 : 125-128, 2015.
PubMed
7) Green BJ, et al : Potentially pathogenic airway bacteria and neutrophilic inflammation in treatment resistant severe asthma. PLoS ONE 9 : e100645, 2014.
PubMed
8) Baptist AP, et al : Distinct Asthma Phenotypes Among Older Adults with Asthma. J Allergy Clin Immunol Pract 6 : 244-249. e2, 2018.
 
9) Simpson JL, et al : Clarithromycin targets neutrophilic airway inflammation in refractory asthma. Am J Respir Crit Care Med 177 : 148-155, 2008.
PubMed
10) Magnussen H, et al : Improvements with tiotropium in COPD patients with concomitant asthma. Respir Med 102 : 50-56, 2008.
PubMed
11) Sin DD, Tu JV : Inhaled corticosteroid therapy reduces the risk of rehospitalization and all-cause mortality in elderly asthmatics. Eur Respir J 17 : 380-385, 2001.
PubMed
P.264 掲載の参考文献
1) 日本呼吸器学会 (編) : COPD (慢性閉塞性肺疾患) 診断と治療のためのガイドライン, 第5版, 2018. メディカルレビュー社, 2018.
 
2) Fabbri LM, Rabe KF : From COPD to chronic systemic inflammatory syndrome? Lancet 370 : 797-799, 2007.
PubMed
3) 日本老年医学会・国立長寿医療研究センター荒井秀典 (編) : フレイル診療ガイド 2018年版 ライフ・サイエンス社, 2018.
 
4) 日本老年医学会サルコペニア : 定義と診断に関する欧州関連学会のコンセンサスの監訳とQ&A. [https://www.jpn-geriat-soc.or.jp/info/topics/pdf/sarcopenia_EWGSOP_jpn-j-geriat2012.pdf] (2018年4月閲覧)
 
5) Wagg K : Unravelling self-management for COPD : what next? Chron Respir Dis 9 : 5-7, 2012.
PubMed
6) Fletcher C, et al : The natural history of chronic airflow obstruction. Br Med J 1 : 1645-1648, 1977.
PubMed
7) Sayer AA, Peto R : The developmental origins of sarcopenia. J Nutr Health Aging 12 : 427-432, 2008.
 
8) Galizia G, et al : Role of clinical frailty on long-term mortality of elderly subjects with and without chronic obstructive pulmonary disease. Aging Clin Exp Res 23 : 118-125, 2011.
PubMed
9) Park SK, et al : Frailty in people with COPD, using the National Health and Nutrition Evaluation Survey dataset (2003-2006). Heart Lung 42 : 163-170, 2013.
PubMed
10) Lahousse L, et al : Risk of Frailty in Elderly With COPD : A Population-Based Study. J Gerontol A Biol Sci Med Sci 71 : 689-695, 2016.
PubMed
11) Maddocks M, et al : Physical frailty and pulmonary rehabilitation in COPD : a prospective cohort study. Thorax 71 : 988-995, 2016.
PubMed
12) Ko FW, et al : Comprehensive care programme for patients with chronic obstructive pulmonary disease : a randomised controlled trial. Thorax 72 : 122-128, 2017.
PubMed
13) 日本呼吸器学会 (編) : 喘息とCOPDのオーバーラップ (Asthma and COPD Overlap ; ACO) 診断と治療の手引き, 2018, メディカルレビュー社, 2018.
 
P.269 掲載の参考文献
1) Travis WD, et al : An official American Thoracic Society/European Respiratory Society statement : Update of the international multidisciplinary classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med 188 : 733-748, 2013.
PubMed
2) 日本呼吸器学会びまん性肺疾患診断・治療ガイドライン作成委員会 (編) : 特発性間質性肺炎診断と治療の手引き, 改訂第3版, 南江堂, 2016.
 
3) du Bois RM : Genetic factors in pulmonary fibrotic disorders. Semin Respir Crit Care Med 27 : 581-588, 2006.
PubMed
4) Natsuizaka M, et al : Epidemiologic survey of Japanese patients with idiopathic pulmonary fibrosis and investigation of ethnic differences. Am J Respir Crit Care Med 190 : 773-779, 2014.
PubMed
5) Noble PW, et al : Pirfenidone for idiopathic pulmonary fibrosis : analysis of pooled data from three multinational phase 3 trials. Eur Respir J 47 : 243-253, 2016.
PubMed
6) Nathan SD, et al : Effect of pirfenidone on mortality : pooled analyses and meta-analyses of clinical trials in idiopathic pulmonary fibrosis. Lancet Respir Med 5 : 33-41, 2017.
PubMed
7) Costabel U, et al : Efficacy of Nintedanib in Idiopathic Pulmonary Fibrosis across Prespecified Subgroups in INPULSIS. Am J Respir Crit Care Med 193 : 178-185, 2016.
PubMed
8) Sakamoto S, et al : Effectiveness of combined therapy with pirfenidone and inhaled N-acetylcysteine for advanced idiopathic pulmonary fibrosis : acase-control study. Respirology 20 : 445-452, 2015.
 
9) 日本呼吸器学会肺生理専門委員会/日本呼吸管理学会酸素療法ガイドライン作成委員会 (編) : 酸素療法ガイドライン, メディカルレビュー社, 2006.
 
10) Dowman L, et al : Pulmonary rehabilitation for interstitial lung disease. Cochrane Database Syst Rev (10) : CD006322, 2014.
 
11) 神津玲, ほか : 間質性肺炎患者に対する呼吸リハビリテーションの現状と課題. 日本呼吸ケア・リハビリテーション学会誌 20 : 14-18, 2010.
 
12) Raghu G, et al : An official ATS/ERS/JRS/ALAT statement : idiopathic pulmonary fibrosis : evidencebased guidelines for diagnosis and management. Am J Respir Crit Care Med 183 : 788-824, 2011.
PubMed
13) 日本呼吸ケア・リハビリテーション学会/日本呼吸器学会/日本リハビリテーション医学会/日本理学療法士協会 (編) : 呼吸リハビリテーションマニュアル-運動療法-第2版, 照林社, 2012.
 
14) Lee JS, et al : Anti-acid treatment and disease progression in idiopathic pulmonary fibrosis : an analysis of data from three randomised controlled trials. Lancet Respir Med 1 : 369-376, 2013.
PubMed
15) Ozawa Y, et al : Cumulative incidence of and predictive factors for lung cancer in IPF. Respirology 14 : 723-728, 2009.
PubMed
P.275 掲載の参考文献
1) 日本呼吸ケア・リハビリテーション学会, 日本呼吸器学会 (編) : 酸素療法マニュアル, メディカルレビュー社, 2017.
 
2) Rossi A, et al : Aging and the respiratory system. Aging (Milano) 8 : 143-161, 1996.
PubMed
3) Cerveri I, et al : Reference values of arterial oxygen tension in the middle-aged and elderly. Am J Respir Crit Care Med 152 : 934-941, 1995.
PubMed
4) Tarpy SP, Celli BR : Long-term oxygen therapy. N Engl J Med 333 : 710-714, 1995.
PubMed
5) 日本呼吸器学会, 在宅呼吸ケア白書作成委員会 : 在宅呼吸ケア白書, 文光堂, 2005.
 
6) 日本呼吸器学会肺生理専門委員会, 在宅呼吸ケア白書ワーキンググループ : 在宅呼吸ケア白書 2010, メディカルレビュー社, 2010.
 
7) 長瀬洋之 : 間質性肺炎にみられる呼吸不全. THE LUNG perspectives 19 : 24-27, 2011.
Medical*Online
8) Dodd JW : Lung disease as a determinant of cognitive decline and dementia. Alzheimer Res Ther 7 : 32, 2015.
 
9) Cleutjens FA, et al : Cognitive-pulmonary disease. Biomed Res Int 2014 : 697825, 2014.
PubMed
10) Wen XH, et al : The relationship between cognitive function and arterial partial pressure O2 in patients with COPD : A meta-analysis. Medicine (Baltimore) 97 : e9599, 2018.
PubMed
11) Dal Negro RW, et al : Cognitive dysfunction in severe chronic obstructive pulmonary disease (COPD) with or without Long-Term Oxygen Therapy (LTOT). Multidiscip Respir Med 10 (1) : 17, 2015. (doi : 10.1186/s40248-015-0013-4)
 
12) Shoji K, et al : Role of hypoxia in progressive chronic kidney disease and implications for therapy. Curr Opin Nephrol Hypertens 23 : 161-168, 2014.
PubMed
13) Mapel D : Renal and hepatobiliary dysfunction in chronic obstructive pulmonary disease. Curr Opin Pulm Med 20 : 186-193, 2014.
PubMed
14) Bratel T, et al : Renal function in hypoxaemic chronic obstructive pulmonary disease : effects of long-term oxygen treatment. Respir Med 97 : 308-316, 2003.
PubMed
15) Wang H, et al : The organ specificity in pathological damage of chronic intermittent hypoxia : an experimental study on rat with high-fat diet. Sleep Breath 17 : 957-965, 2013.
 
16) Hattori K, et al : Relationship between serum cardiac troponin T level and cardiopulmonary function in stable chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 10 : 309-320, 2015.
PubMed
17) Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease : a clinical trial. Nocturnal Oxygen Therapy Trial Group. Ann Intern Med 93 : 391-398, 1980.
 
18) Long term domiciliary oxygen therapy in chronic hypoxic cor pulmonale complicating chronic bronchitis and emphysema. Report of the Medical Research Council Working Party. Lancet 1 : 681-686, 1981.
PubMed
19) 桂秀樹 : 高齢者の在宅酸素療法. THE LUNG perspectives 20 : 66-73, 2012.
 
20) Katsura H, et al : Factors determining outcome in elderly patients with severe COPD on long-term domiciliary oxygen therapy. Monaldi Arch Chest Dis 56 : 195-201, 2001.
PubMed
21) 日本呼吸器学会NPPVガイドライン作成委員会 : NPPV (非侵襲的陽圧換気療法) ガイドライン, 改訂第2版, 南江堂, 2015.
 
22) Schortgen F, et al : Results of noninvasive ventilation in very old patients. Ann Intensive Care 2 : 5, 2012.
PubMed
23) 植木純, ほか : 呼吸リハビリテーションに関するステートメント. 日本呼吸ケア・リハビリテーション学会誌 27 : 95-114, 2018.
 
24) Katsura H, et al : Long-term effectiveness of an inpatient pulmonary rehabilitation program for elderly COPD patients : comparison between young-elderly and old-elderly groups. Respirology 9 : 230-236, 2004.
PubMed
25) 桂秀樹 : 非がん性呼吸器疾患の緩和ケア (津田徹, 平原左斗司編), p7-13, 南山堂, 2017.
 
26) Higginson IJ, et al : An integrated palliative and respiratory care service for patients with advanced disease and refractory breathlessness : a randomised controlled trial. Lancet Respir Med 2 : 979-987, 2014.
PubMed
P.281 掲載の参考文献
1) 政府統計の総合窓口 (e-Stat) [https://www.e-stat.go.jp] (2018年5月5日参照)
 
2) Hirokawa K : Age-related changes of thymus-morphological and functional aspects. Acta Pathol Jpn 28 : 843-857, 1978.
PubMed
3) Shimada Y, et al : Age-associated up-regulation of a negative co-stimulatory receptor PD-1 in mouse CD4+ T cells. Exp Gerontol 44 : 517-522, 2009.
PubMed
4) Li G, et al : Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity. Nat Med 18 : 1518-1524, 2012.
PubMed
5) 永井厚志 : 気道疾患における線毛の超微形態学的研究. 日本胸部疾患学会雑誌 21 : 564-573, 1983.
 
6) Johnstone J, et al : Viral infection in adults hospitalized with community-acquired pneumonia : prevalence, pathogens, and presentation. Chest 134 : 1141-1148, 2008.
PubMed
7) Karhu J, et al : Lower respiratory tract virus findings in mechanically ventilated patients with severe community-acquired pneumonia. Clin Infect Dis 59 : 62-70, 2014.
PubMed
8) Haga T, et al : Computed Tomography for the Diagnosis and Evaluation of the Severity of Community-acquired Pneumonia in the Elderly. Intern Med 55 : 437-441, 2016.
PubMed
9) 長置健司 : 肺炎の診断における胸部CTの有用性についての検討. 日本医学放射線学会雑誌 57 : 258-264, 1997.
 
10) 日本呼吸器学会成人肺炎診療ガイドライン 2017作成委員会 (編) : 成人肺炎診療ガイドライン 2017, 日本呼吸器学, 2017.
 
11) Teramoto S, et al : High incidence of aspiration pneumonia in community- and hospital-acquired pneumonia in hospitalized patients : a multicenter, prospective study in Japan. J Am Geriatr Soc 56 : 577-579, 2008.
PubMed
12) Yamasaki K, et al : Significance of anaerobes and oral bacteria in community-acquired pneumonia. PLoS ONE 8 : e63103, 2013.
PubMed
13) Miyashita N, et al : Is it possible to distinguish between atypical pneumonia and bacterial pneumonia? : evaluation of the guidelines for community-acquired pneumonia in Japan. Respir Med 98 : 952-960, 2004.
PubMed
14) Altenburg J, et al : Immunomodulatory effects of macrolide antibiotics-part 1 : biological mechanisms. Respiration 81 : 67-74, 2011.
PubMed
15) 厚生労働省 : 人生の最終段階における医療の決定プロセスに関するガイドライン (平成19年発表, 平成27年改訂). [http://www.mhlw.go.jp/file/04-Houdouhappyou-10802000-Iseikyoku-Shidouka/0000197701.pdf] (2018年6月閲覧)
 
P.285 掲載の参考文献
1) Marik PE : Pulmonary aspiration syndromes. Curr Opin Pulm Med 17 : 148-154, 2011.
PubMed
2) Hu X, et al : Aspiration-related pulmonary syndromes. Chest 147 : 815-823, 2015.
PubMed
3) de Carlos F, et al : The sensory innervation of the human pharynx : searching for mechanoreceptors. Anat Rec (Hoboken) 296 : 1735-1746, 2013.
PubMed
4) Maeda K, Akagi J : Decreased tongue pressure is associated with sarcopenia and sarcopenic dysphagia in the elderly. Dysphagia 30 : 80-87, 2015.
PubMed
5) Maeda K, Akagi J : Sarcopenia is an independent risk factor of dysphagia in hospitalized older people. Geriatr Gerontol Int 16 : 515-521, 2016.
PubMed
6) Maeda K, Akagi J : Muscle Mass Loss Is a Potential Predictor of 90-Day Mortality in Older Adults with Aspiration Pneumonia J Am Geriatr Soc 65 : e18-e22, 2017.
PubMed
7) Komatsu R, et al : Aspiration pneumonia induces muscle atrophy in the respiratory, skeletal, and swallowing systems. J Cachexia Sarcopenia Muscle, 2018. (in press)
 
8) 山谷睦雄 : 高齢者肺炎の発症に関わる要因と遺伝子. Geriatric Medicine 55 : 1211-1215, 2017.
Medical*Online
9) Jayasekeran V, et al : Val66Met in brain-derived neurotrophic factor affects stimulus-induced plasticity in the human pharyngeal motor cortex. Gastroenterology 141 : 827-836. e1-3, 2011,
 
10) Mentz H, et al : Homozygosity in the ApoE 4 polymorphism is associated with dysphagic symptoms in older adults. Dis Esophagus 28 : 97-103, 2015.
PubMed
11) Nimmons D, et al : A novel association between COMT and BDNF gene polymorphisms and likelihood of symptomatic dysphagia in older people. Neurogastroenterol Motil 27 : 1223-1231, 2015.
PubMed
12) 日本呼吸器学会成人肺炎診療ガイドライン 2017作成委員会 : 成人肺炎診療ガイドライン 2017, 日本呼吸器学会, 2017.
 
P.290 掲載の参考文献
1) 肺癌診療ガイドライン 2017年度版, IV期非小細胞肺癌薬物療法 (日本肺癌学会編), 金原出版, 2017.
 
2) Kohno T, et al : Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer. Transl Lung Cancer Res 4 : 156-164, 2015.
PubMed
3) Maemondo M, et al : First-line gefitinib in patients aged 75 or older with advanced non-small cell lung cancer harboring epidermal growth factor receptor mutations : NEJ 003 study. J Thorac Oncol 7 : 1417-1422, 2012.
 
4) Goto K, et al : A prospective, phase ll, open-label study (JO22903) of first-line erlotinib in Japanese patients with epidermal growth factor receptor (EGFR) mutation-positive advanced non-small-cell lung cancer (NSCLC). Lung Cancer 82 : 109-114, 2013.
 
5) Janne PA, et al : AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer. N Engl J Med 372 : 1689-1699, 2015.
PubMed
6) Soria JC, et al : Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer. N Engl J Med 378 : 113-125, 2018.
PubMed
7) Nanjo S et al : High efficacy of third generation EGFR inhibitor AZD9291 in a leptomeningeal carcinomatosis model with EGFR-mutant lung cancer cells. Oncotarget 26 : 3847-3856, 2016.
 
8) Effects of vinorelbine on quality of life and survival of elderly patients with advanced non-small-cell lung cancer. The Elderly Lung Cancer Vinorelbine Italian Study Group. J Natl Cancer Inst 91 : 66-72, 1999.
 
9) Kudoh S, et al : Phase III study of docetaxel compared with vinorelbine in elderly patients with advanced non-small-cell lung cancer : results of the West Japan Thoracic Oncology Group Trial (WJTOG 9904). J Clin Oncol 24 : 3657-3663, 2006.
PubMed
10) Quoix E, et al : Carboplatin and weekly paclitaxel doublet chemotherapy compared with monotherapy in elderly patients with advanced non-small-cell lung cancer : IFCT-0501 randomised, phase 3 trial. Lancet 378 : 1079-1088, 2011.
PubMed
11) Poropatich K, et al : Cancer Immunotherapies : Are They as Effective in the Elderly? Drugs Aging 34 : 567-581, 2017.
PubMed
12) Nishijima TF, et al : Comparison of efficacy of immune checkpoint inhibitors (ICIs) between younger and older patients : A systematic review and meta-analysis. Cancer Treat Rev 45 : 30-37, 2016.
PubMed
13) 高齢者研究, Japan Clinical Oncology Group. [http://www.jcog.jp/basic/policy/A_020_0010_39.pdf] (2018年7月閲覧)
 
P.296 掲載の参考文献
1) 平成28年結核登録者情報調査年報集計結果について [http://www.mhlw.go.jp/file/06-Seisakujouhou-10900000-Kenkoukyoku/0000175603.pdf] (2018年6月閲覧)
 
2) Marion CR, High KP : Tuberculosis in older adults. In : Infectious Disease in the Aging : A Clinical Handbook, 2nd edition (ed by Yoshikawa TT, Norman DC), p97-110, Humana Press, London, 2009.
 
3) Resnick NM, Dosa D : Geriatric medicine. In : Harrison's Principles of Internal Medicine, 16th ed (ed by Kasper DL, et al), p 43-53, McGraw-Hill, New York, 2004.
 
4) Norman DC : Clinical features of Infection. In : Infectious Disease in the Aging : A Clinical Handbook, 2nd edition (ed by Yoshikawa TT, Norman DC), p19-28, Humana Press, London, 2009.
 
5) Kahneman D : Norms, surprises, and causes. In : Thinking, Fast and Slow, p71-78, Penguin Books, London, 2011.
 
6) Croskerry P : Achieving quality in clinical decision making : cognitive strategies and detection of bias. Acad Emerg Med 9 : 1184-1204, 2002.
PubMed
7) Ham RM : Clinical intuition and clinical analysis. Expertise and the cognitive continuum. In : Professional Judgment : A Reader in Clinical Decision Making (ed by Dowie J, Elstein A), p78-105, Cambridge University Press, Cambridge, 1988.
 
8) Schon DA : From technical rationality to reflection-in-action. In Professional Judgment. A Reader in Clinical Decision Making (ed by Dowie J, Elstein A), 60-77, Cambridge University Press, Cambridge, 1988.
 
9) Bacterial pneumonia. In : Imaging of Pulmonary Infections (ed by Muller NL, et al), p20-55, Lippincott Wiliams & Wilkins, Philadelphia, 2007.
 
P.301 掲載の参考文献
1) Wolf PA, et al : Atrial fibrillation as an independent risk factor for stroke : the Framingham Study. Stroke 22 : 983-988, 1991.
PubMed
2) Echt DS, et al : Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial. N Engl J Med 324 : 781-78&1991.
 
3) Wyse DG, et al : A comparison of rate control and rhythm control in patients with atrial fibrillation. N Engl J Med 347 : 1825-1833, 2002.
PubMed
4) Misiaszek B, et al : Digoxin prescribing for heart failure in elderly residents of long-term care facilities. Can J Cardiol 21 : 281-286, 2005.
PubMed
5) Dungen HD, et al : Titration to target dose of bisoprolol vs. carvedilol in elderly patients with heart failure : the CIBIS-ELD trial. Eur J Heart Fail 13 : 670-680, 2011.
PubMed
6) ACTIVE Writing Group of the ACTIVE Investigators, et al : Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W) : a randomised controlled trial. Lancet 367 : 1903-1912, 2006.
 
7) Connolly SJ, et al : Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 361 : 1139-1151, 2009.
PubMed
8) Patel MR, et al : Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med 365 : 883-891, 2011.
PubMed
9) Connolly SJ, et al : Apixaban in patients with atrial fibrillation. N Engl J Med 364 : 806-817, 2011.
PubMed
10) Giugliano RP, et al : Edoxaban versus warfarin in patients with atrial fibrillation. N Engl J Med 369 : 2093-2104, 2013.
PubMed
11) Gage BF, et al : Validation of clinical classification schemes for predicting stroke : results from the National Registry of Atrial Fibrillation. JAMA 285 : 2864-2870, 2001.
 
12) Boriani G, et al : Improving stroke risk stratification using the CHADS2 and CHA2DS2-VASc risk scores in patients with paroxysmal atrial fibrillation by continuous arrhythmia burden monitoring. Stroke 42 : 1768-1770, 2011.
PubMed
13) Hart RG, et al : Stroke with intermittent atrial fibrillation : incidence and predictors during aspirin therapy. Stroke Prevention in Atrial Fibrillation Investigators. J Am Coll Cardiol 35 : 183-187, 2000.
PubMed
14) Pisters R, et al : A novel user-friendly score (HAS-BLED) to assess l-year risk of major bleeding in patients with atrial fibrillation : the Euro Heart Survey. Chest 138 : 1093-1100, 2010.
PubMed
P.307 掲載の参考文献
1) Zipes DP, et al : Braunwald's Heart Disease, A Textbook of Cardiovascular Medicine, 11th ed, ELSEVIER, Philadelphia, 2018.
 
2) Arbab-Zadeh A, Hoe J : Quantification of coronary arterial stenoses by multidetector CT angiography in comparison with conventional angiography methods, caveats, and implications. JACC Cardiovasc Imaging 4 : 191-202, 2011.
PubMed
3) 日本高血圧学会高血圧治療ガイドライン作成委員会 (編) : 高血圧治療ガイドライン 2014, 日本高血圧学会, 2014. .
 
4) Fagard RH, et al : On-treatment diastolic blood pressure and prognosis in systolic hypertension. Arch Intern Med 167 : 1884-1891, 2007.
PubMed
5) 日本動脈硬化学会 : 動脈硬化性疾患予防ガイドライン 2017, 日本動脈硬化学会, 2017.
Medical*Online
6) 日本老年医学会・日本糖尿病学会 : 高齢者糖尿病診療ガイドライン 2017, 南江堂, 2017.
 
7) Boden WE, et al : Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med 356 : 1503-1516, 2007.
 
8) De Bruyne B, et al : Fractional flow reserve-guided PCI for stable coronary artery disease. N Engl J Med 371 : 1208-1217, 2014.
PubMed
9) Patel MR, et al : ACCF/SCAI/STS/AATS/AHA/ASNC/HFSA/SCCT 2012 Appropriate use criteria for coronary revascularization focused update. J Am Coll Cardiol 59 : 857-881, 2012.
PubMed
10) Desai NR, et al : Appropriate Use Criteria for Coronary Revascularization and Trends in Utilization, Patient Selection, and Appropriateness of Percutaneous Coronary Intervention. JAMA 314 : 2045-2053, 2015.
PubMed
11) Dewilde WJ, et al : Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention : an open-label, randomised, controlled trial. Lancet 381 : 1107-1115, 2013.
 
12) Gibson CM, et al : Prevention of Bleeding in Patients with Atrial Fibrillation Undergoing PCI. N Engl J Med 375 : 2423-2434, 2016.
PubMed
13) Valgimigli M, et al : 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS. Eur Heart J 39 : 213-260, 2018.
PubMed
14) Tse G, et al : Frailty and Mortality Outcomes After Percutaneous Coronary Intervention : A Systematic Review and Meta-Analysis. J Am Med Dir Assoc 18 : 1097. : e1-e1097. e10, 2017.
 
15) Wada H, et al : Prognostic Impact of the Geriatric Nutritional Risk Index on Long-Term Outcomes in Patients Who Underwent Percutaneous Coronary Intervention. Am J Cardiol 119 : 1740-1745, 2017.
PubMed
P.312 掲載の参考文献
1) Komajda M, et al : Contemporary management of octogenarians hospitalized for heart failure in Europe : Euro Heart Failure Survey II. Eur Heart J 30 : 478-486, 2009.
PubMed
2) Tsuchihashi-Makaya M, et al : Characteristics and outcomes of hospitalized patients with heart failure and reduced vs preserved ejection fraction. Report from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) : Circ J 73 : 1893-1900, 2009.
PubMed
3) Tresch DD, McGough MF : Heart failure with normal systolic function : a common disorder in older people. J Am Geriatr Soc 43 : 1035-1042, 1995.
 
4) Kajstura J, et al : Myocyte turnover in the aging human heart. Circ Res 107 : 1374-1386, 2010.
PubMed
5) Taffet GE, et al : Survival of elderly men with congestive heart failure. Age Ageing 21 : 49-55, 1992.
PubMed
6) Schoenenberger AW, et al : Predictors of functional decline in elderly patients undergoing transcatheter aortic valve implantation (TAVI). Eur Heart J 34 : 684-692, 2013.
PubMed
7) Ponikowski P, et al : Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiency. Eur Heart J 36 : 657-668, 2015.
PubMed
8) Rodriguez-Pascual C, et al : The frailty syndrome is associated with adverse health outcomes in very old patients with stable heart failure : A prospective study in six Spanish hospitals. Int J Cardiol 236 : 296-303, 2017.
PubMed
9) Denfeld QE, et al : Frequency of and Significance of Physical Frailty in Patients With Heart Failure. Am J Cardiol 119 : 1243-1249, 2017.
PubMed
10) Abdul-Rahim AH, et al : Risk of Stroke in Chronic Heart Failure Patients Without Atrial Fibrillation : Analysis of the Controlled Rosuvastatin in Multinational Trial Heart Failure (CORONA) and the Gruppo Italiano per lo Studio della Sopravvivenza nelrInsufficienza Cardiaca-Heart Failure (GISSI-HF) Trials. Circulation 131 : 1486-1494 ; discussion 1494, 2015.
PubMed
11) Smith EE, et al : Cerebral microinfarcts : the invisible lesions. Lancet Neurol 11 : 272-282, 2012.
PubMed
12) Damman K, et al : Renal impairment, worsening renal function, and outcome in patients with heart failure : an updated meta-analysis. Eur Heart J 35 : 455-469, 2014.
PubMed
13) Dos Santos MR, et al : Sarcopenia and Endothelial Function in Patients With Chronic Heart Failure : Results From the Studies Investigating Comorbidities Aggravating Heart Failure (SICA-HF). J Am Med Dir Assoc 18 : 240-245, 2017.
PubMed
P.318 掲載の参考文献
1) [http://www.stat.go.jp/data/jinsui/pdf/201804.pdf] (2018年7月閲覧)
 
2) Nkomo VT, et al : Burden of valvular heart diseases : a population-based study. Lancet 368 : 1005-1011, 2006.
PubMed
3) d'Arcy JL, et al : Valvular heart disease : the next cardiac epidemic. Heart 97 : 91-93, 2011.
PubMed
4) Iung B, Vahanian A : Epidemiology of valvular heart disease in the adult. Nat Rev Cardiol 8 : 162-172, 2011.
PubMed
5) Bonow RO, et al : 2008 Focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease : a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease) : endorsed by the Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. Circulation 118 : e523-661, 2008.
 
6) Iung B, et al : A prospective survey of patients with valvular heart disease in Europe : The Euro Heart Survey on Valvular Heart Disease. Eur Heart J 24 : 1231-1243, 2003.
PubMed
7) Ito K, et al : Mechanism of atrial functional mitral regurgitation in patients with atrial fibrillation : A study using three-dimensional transesophageal echocardiography. J Cardiol 70 : 584-590, 2017.
PubMed
8) Machino-Ohtsuka T, et al : Novel Mechanistic Insights Into Atrial Functional Mitral Regurgitation-3-Dimensional Echocardiographic Study. Circ J 80 : 2240-2248, 2016.
PubMed
9) 大北裕, ほか : 循環器病の診断と治療に関するガイドライン (2011年度合同研究班報告), 弁膜疾患の非薬物治療に関するガイドライン (2012年改訂版).
 
10) Zhou X, et al : Impact of atrial fibrillation on tricuspid and mitral annular dilatation and valvular regurgitation. Circ J 66 : 913-916, 2002.
PubMed
11) Utsunomiya H, et al : Functional Tricuspid Regurgitation Caused by Chronic Atrial Fibrillation : A Real-Time 3-Dimensional Transesophageal Echocardiography Study. Circ Cardiovasc Imaging 10 : 2017.
PubMed
12) Eveborn GW, et al : The evolving epidemiology of valvular aortic stenosis. the Tromso study. Heart 99 : 396-400, 2013.
PubMed
13) Ross J Jr, Braunwald E : Aortic Stenosis. Circulation 38 (1 Suppl) : 61-67, 1968
 
14) Langanay T, et al : Aortic valve replacement in the elderly : the real life. Ann Thorac Surg 93 : 70-77 ; discussion 77-78, 2012.
 
15) Bonow RO : Asymptomatic Aortic Stenosis : It Is Not Simple Anymore. J Am Coll Cardiol 66 : 2839-2841, 2015.
PubMed
16) Nishimura RA, et al : 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease. Circulation 129 : e521-643, 2014.
 
17) Steiner JM, et al : Palliative care in end-stage valvular heart disease. Heart 103 : 1233-1237, 2017.
PubMed
18) Brunner-La Rocca HP, et al : End-of-life preferences of elderly patients with chronic heart failure. Eur Heart J 33 : 752-759, 2012.
PubMed
19) Hamel MB, et al : Age-related differences in care preferences, treatment decisions, and clinical outcomes of seriously ill hospitalized adults : lessons from SUPPORT. J Am Geriatr Soc 48 : S176-182, 2000.
PubMed
20) [http://riskcalc.sts.org/] (2018年7月閲覧)
 
21) [https://center6.umin.ac.jp/islet/jcvsd/index.html]
 
22) Barasch E, et al : Clinical and echocardiographic correlates of mortality in medically treated patients with severe isolated aortic stenosis and normal left ventricular ejection fraction. Circ J 78 : 232-239, 2014.
PubMed
P.324 掲載の参考文献
1) Norgren L, et al : Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II). J Vasc Surg 45 (Suppl S) : S5-67, 2007.
 
2) 日本循環器学会, ほか : 末梢閉塞性動脈疾患の治療ガイドライン (2015年改訂版), 2015. [http://www.j-circ.or.jp/guideline/pdf/JCS2015_miyata_h.pdf] (2018年7月閲覧)
 
3) 古森公浩 : Peripheral Arterial Diseaseの診断と治療 : 新しいガイドライン TASCII. Coronary Intervention 3 : 15-22, 2007. (メディアルファ)
 
4) 古森公浩 : 末梢動脈閉塞症 (Peripheral arterial disease : PAD) に対する最新の治療戦略. 日本血栓止血学会誌 24 : 38-44, 2013.
 
5) Takahara M, et al : Absence of Preceding Intermittent Claudication and its Associated Clinical Freatures in Patients with Critical Limb Ischemia. J Atheroscler Thromb 22 : 718-725, 2015.
PubMed
6) Diehm N, et al : Association of cardiovascular risk factors with pattern of lower limb atherosclerosis in 2659 patients undergoing angioplasty. Eur J Vasc Endovasc Surg 31 : 59-63, 2006.
PubMed
7) Maekawa T, et al : The impact of inflow treatment for claudicants with both aortoiliac and femoropopliteal occlusive disease. Surg Today 47 : 293-300, 2017.
PubMed
8) Tosaka A, et al : Classification and clinical impact of restenosis after femoropopliteal stenting. J Am Coll Cardiol 59 : 16-23, 2012.
PubMed
9) Klinkert P, et al : Vein versus polytetrafluoroethylene in above-knee femoropopliteal bypass grafting : five-year results of a randomized controlled trial. J Vasc Surg 37 : 149-155, 2003.
PubMed
10) Johnson WC, Lee KK : A comparative evaluation of polytetrafluoroethylene, umbilical vein, and saphenous vein bypass grafts for femoral-popliteal above-knee revascularization : a prospective randomized Department of Veterans Affairs cooperative study. J Vasc Surg 32 : 268-277, 2000.
PubMed
11) Soga Y, et al : Comparison of clinical outcome after bypass surgery vs. endovascular therapy for infrainguinal artery disease in patients with critical limb ischemia. Circ J 77 : 2102-2109, 2013.
PubMed
12) Bradbury AW, et al : Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL) trial : Analysis of amputation free and overall survival by treatment received. J Vasc Surg 51 : 18S-31S, 2010.
PubMed
P.329 掲載の参考文献
1) Low PA : Prevalence of orthostatic hypotension. Clin Auton Res. 18 (Supple 1) : 8-13, 2008.
 
2) Ricci F, et al : Orthostatic Hypotension : Epidemiology, Prognosis, and Treatment. J Am Coll Cardiol 66 : 848-860, 2015.
PubMed
3) Xin W, et al : Orthostatic hypotension and mortality risk : a meta-analysis of cohort studies. Heart 100 : 406-413, 2014.
 
4) Xin W, et al : Orthostatic hypotension and the risk of incidental cardiovascular diseases : A meta-analysis of prospective cohort studies. Prev Med 85 : 90-97, 2016.
PubMed
5) Gibbons CH, et al : The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension. J Neurol 264 : 1567-1582, 2017.
PubMed
6) Trahair LG, et al : Postprandial hypotension : a systematic review. J Am Med Dir Assoc 15 : 394-409, 2014.
PubMed
7) Toba A, et al : Impact of age on left ventricular geometry and diastolic function in elderly patients with treated hypertension. Blood Press 26 : 264-271, 2017.
PubMed
8) Toba A, et al : Orthostatic hypotension and association of arterial compliance in elderly patients with hypertension : a pilot study. Blood Press Monit 22 : 274-278, 2017.
PubMed
9) Shibao C, et al : Acarbose, an alpha-glucosidase inhibitor, attenuates postprandial hypotension in autonomic failure. Hypertension 50 : 54-61, 2007.
PubMed
10) Ninomiya T. et al : Midlife and late-life blood pressure and dementia in Japanese elderly : the Hisayama study. Hypertension 58 : 22-28, 2011.
PubMed
11) Ravindrarajah R, et al : Systolic blood pressure trajectory, frailty and all-cause mortality > 80 years of age. Cohort study using electronic health records. Circulation 135 : 2357-2368, 2017
PubMed
12) Ryuno H, et al : Differences in the association between high blood pressure and cognitive functioning among the general Japanese population aged 70 and 80 years : The SONIC study. Hypertens Res 39 : 557-563, 2016.
PubMed
13) Mossello E, et al : Effects of low blood pressure in cognitively impaired elderly patients treated with antihypertensive drugs. JAMA Intern Med 175 : 578-585, 2015.
PubMed
14) Sakakura K, et al : Association of body mass index with cognitive function in elderly hypertensive Japanese. Am J Hypertens 21 : 627-632, 2008.
PubMed
P.336 掲載の参考文献
1) Young T, et al : The occurrence of sleep-disordered breathing among middle-aged adults, N Engl J Med 328 : 1230-1235, 1993.
PubMed
2) Russell T, et al : Sleep disordered breathing in the elderly. Am J Med 124 : 1123-1126, 2011.
PubMed
3) Young T, et al : Predictors of sleep-disordered breathing in community-dwelling adults : the Sleep Heart Health Study. Arch Intern Med 162 : 893-900, 2002.
PubMed
4) Lavie P, et al : Unexpected survival advantage in elderly people with moderate sleep apnoea. J Sleep Res 18 : 397-403, 2009.
PubMed
5) Martinez-Garcia MA, et al : Cardiovascular mortality in obstructive sleep apnea in the elderly : role of long-term continu0us positive airway pressure treatment : a prospective observational study. Am J Respir Crit Care Med 186 : 909-916, 2012,
PubMed
6) Punjabi NM, et al : Sleep-disordered breathing, glucose intolerance, and insulin resistance : the Sleep Heart Health Study. Am J Epidemiol 160 : 521-530, 2004.
PubMed
7) Peppard PE, et al : Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 342 : 1378-1384, 2000.
PubMed
8) Nieto FJ, et al : Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study. JAMA 283 : 1829-1836, 2000.
 
9) Bradley TD, et al : Sleep apnea and heart failure : Part I : obstructive sleep apnea. Circulation 107 : 1671-1678, 2003.
PubMed
10) Marin JM, et al : Long-term cardiovascular outcomes in men with obstructive sleep apnoeahypopnoea with or without treatment with continuous positive airway pressure : an observational study. Lancet 365 : 1046-1053, 2005.
PubMed
11) Mehra R, et al : Association of nocturnal arrhythmias with sleep-disordered breathing : The Sleep Heart Health Study. Am J Respir Crit Care Med 173 : 910-916, 2006.
PubMed
12) Cowie MR, et al : Adaptive Servo-Ventilation for Central Sleep Apnea in Systolic Heart Failure. N Engl J Med 373 : 1095-llO5, 2015.
PubMed
13) Iftikhar IH, et al : Comparative efficacy of CPAP, MADs, exercise-training, and dietary weight loss for sleep apnea : a network meta-analysis. Sleep Med 30 : 7-14, 2017.
PubMed
14) McEvoy RD, et al : CPAP for Prevention of Cardiovascular Events in Obstructive Sleep Apnea. N Engl J Med 375 : 919-931, 2016.
PubMed
P.342 掲載の参考文献
1) 国立研究開発法人国立がん研究センターがん対策情報センター. [https://www.ncc.go.jp/jp/cis/index.html] (2018年6月閲覧)
 
2) Rossman I : The anatomy of aging. In : Clinical Geriatrics (ed by Rossman I), p3-19, Lippincott Co Williams & Wilkins, Philadelphia, 1986.
 
3) 内野純一, ほか : 加齢と肝臓外科, 肝・胆・膵 16 : 809-815, 1988.
 
4) 阪森亮太郎, ほか : 高齢者C型肝炎にDAA治療は推奨されるか. 肝臓 58 (Suppl 2) : A520, 2017.
 
5) 日本肝臓学会 (編) : 肝癌診療ガイドライン 2017年版, 金原出版, 2017.
 
6) Abe N, et al : Multicenter study of the long-term outcomes of endoscopic submucosal dissection for early gastric cancer in patients 80 years of age or older. Gastric Cancer 15 : 70-75, 2012.
 
7) Akasaka T, et al : Short-term outcomes of endoscopic submucosal dissection (ESD) for early gastric neoplasm : multicenter survey by osaka university ESD study group. Dig Endosc 23 : 73-77, 2011.
 
8) 林義人, ほか : 手術不能進行胃癌高齢患者に対する化学療法の意義. 日本消化器病学会雑誌 114 (Suppl 2) : 609, 2017.
 
9) Koizumi W, et al : S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial) : a phase III trial. Lancet Oncol 9 : 215-221, 2008.
 
10) Sasaki Y, et al : A phase II study of combination therapy with oral S-1 and cisplatin in elderly patients with advanced gastric cancer. Gastric Cancer 21 : 439-445, 2018.
 
11) Koizumi W, et al : Phase II study of oxaliplatin plus S-1 as first-line treatment for advanced gastric cancer (G-SOX study). Ann Oncol 21 : 1001-1005, 2010.
 
12) Kimura Y, et al : Multicenter phase II study of trastuzumab plus S-1 alone in elderly patients with HER2-positive advanced gastric cancer (JACCRO GC-06). Gastric Cancer 21 : 421-427, 2018.
 
P.346 掲載の参考文献
1) 日本消化器病学会 (編) : 胃食道逆流症 (GERD) 診療ガイドライン 2015, 南江堂, 2015.
 
2) 春日井邦夫, ほか : 逆流性食道炎の診断を正確に行うコツ. 日本消化器内視鏡学会雑誌 56 : 1804-1812, 2014,
 
3) 藤原靖弘 : GERD疫学-最近の動向-. 日本消化器病学会雑誌 114 : 1781-1789, 2017.
Medical*Online
4) Fass R, et al : The effect of auditory stress on perception of intraesophageal acid in patients with gastroesophageal reflux disease. Gastroenterology 134 : 696-705, 2008.
PubMed
5) 木下芳一, ほか : GERDの研究と診療における今後の展開. 日本消化器病学会雑誌 114 : 1765-1773, 2017.
Medical*Online
6) 日本老年医学会 (編) : GERD. 高齢者の安全な薬物療法ガイドライン 2015, p107-111, メジカルビュー社, 2015.
 
7) By the American Geriatrics Society 2015 Beers Criteria Update Expert Panel : American Geriatrics Society 2015 Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. J Am Geriatr Soc 63 : 2227-2246, 2015.
 
8) Targownik L : Discontinuing Long-Term PPI Therapy : Why, With Whom, and How? Am J Gastroenterol 113 : 519-528, 2018.
PubMed
P.352 掲載の参考文献
1) Jeuring SF, et al : Epidemiology and Long-term Outcome of Inflammatory Bowel Disease Diagnosed at Elderly Age-An Increasing Distinct Entity? Inflamm Bowel Dis 22 : 1425-1434, 2016.
PubMed
2) Stepaniuk P, et al : Characterization of inflammatory bowel disease in elderly hospitalized patients in a large central Canadian Health region. Can J Gastroenterol Hepatol 29 : 274-278, 2015.
 
3) Charpentier C, et al : Natural history of elderly-onset inflammatory bowel disease : a population-based cohort study. Gut 63 : 423-432, 2013.
PubMed
4) Zimmerman J, et al : Early and late onset ulcerative colitis : distinct clinical features. J Clin Gastroenterol 7 : 492-498, 1985.
PubMed
5) Ananthakrishnan AN, et al : Inflammatory bowel disease in the elderly is associated with worse outcomes : anational study of hospitalizations. Inflamm Bowel Dis 15 : 182-189, 2009.
 
6) Ananthakrishnan AN, Binion DG : Treatment of ulcerative colitis in the elderly. Dig Dis 27 : 327-334, 2009.
PubMed
7) Vadada D, et al : Inflammatory bowel disease exacerbations after the intiation of aspirin and clopidogrel-a retrospective case control study. Am J Gastroenterol 105 : S472-473, 2011.
 
8) Matsunaga H, et al : Cilostazol, a specific PDE-3 inhibitor, ameliorates chronic ileitis via suppression of interaction of platelets with monocytes. Am J Physiol Gastrointest Liver Physiol 297 : G1077-1084, 2009.
PubMed
9) Cottone M, et al : Advanced age is an independent risk factor for severe infections and mortality in patients given anti-tumor necrosis factor therapy for inflammatory bowel disease. Clin Gastroenterol Hepatol 9 : 30-35, 2011.
PubMed
10) Yajnik V, et al : Efficacy and Safety of Vedolizumab in Ulcerative Colitis and Crohn's Disease Patients Stratified by Age. Adv Ther 34 : 542-559, 2017.
PubMed
11) Komoto S, et al : Safety and efficacy of leukocytapheresis in elderly patients with ulcerative colitis : the impact in steroid-free elderly patients. J Gastroenterol Hepatol, 2018. [Epub ahead of print]
 
12) Beaugerie L, et al : Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease : a prospective observational cohort study. Lancet 374 : 1617-1625, 2009.
PubMed
13) Scott FI, et al : The benefit-to-risk balance of combining infliximab with azathioprine varies with age : a markov model. Clin Gastroenterol Hepatol 13 : 302-309. e11, 2015.
 
14) Ananthakrishnan AN, et al : Excess hospitalisation burden associated with Clostridium difficile in patients with inflammatory bowel disease. Gut 57 : 205-210, 2008.
PubMed
P.356 掲載の参考文献
1) 尾高健夫 : 機能性便秘の診断と治療の実際. 診断と治療 98 : 1477-1482, 2010.
Medical*Online
2) Madsen JL, Graff J : Effects of aging on gastrointestinal motor function. Age Ageing 33 : 154-159, 2004.
PubMed
3) 慢性便秘症診療ガイドライン 2017 (日本消化器病学会関連研究会 (慢性便秘の診断・治療研究会) (編), 南江堂, 2017.
 
4) 中島淳 : 慢性便秘の病態. 診断と治療 101 : 211-216, 2013.
Medical*Online
5) Lacy BE, et al : Bowel Disorders. Gastroenterology 150 : 1393-1407, 2016.
 
6) Lembo A, et al : Chronic constipation. N Engl J Med 349 : 1360-1368, 2003.
PubMed
7) Lindberg G, et al : World Gastroenterology Organisation global guideline : Constipation a global perspective. J Clin Gastroenterol 45 : 483-487, 2011.
PubMed
8) Lembo AJ, et al : Two randomized trials of linaclotide for chronic constipation. N Engl J Med 365 : 527-536, 2011.
PubMed
9) Katakami N, et al : Randomized Phase III and Extension Studies of Naldemedine in Patients With Opioid-lnduced Constipation and Cancer. J Clin Oncol 35 : 3859-3866, 2017.
 
10) Chey WD, et al : A randomized placebo-controlled phase IIb trial of a3309, a bile acid transporter inhibitor, for chronic idiopathic constipation. Am J Gastroenterol 106 : 1803-1812, 2011.
PubMed
11) Nakajima A, et al : Determining an optimal clinical dose of elobixibat, a novel inhibitor of the ileal bile acid transporter, in Japanese patients with chronic constipation : a phase II, multicenter, double-blind, placebo-controlled randomized clinical trial. J Gastroenterol 53 : 525-534, 2018.
PubMed
P.361 掲載の参考文献
1) Kato S, et al : Helicobacter pylori infection-negative gastric cancer in Japanese hospital patients : incidence and pathological characteristics. Cancer Sci 98 : 790-794, 2007.
PubMed
2) Chinda D, et al : Perioperative complications of endoscopic submucosal dissection for early gastric cancer in elderly Japanese patients 75 years of age or older. Intern Med 54 : 267-272, 2015.
 
3) Tsukuma H, et al : Natural history of early gastric cancer : a non-concurrent, long term, follow up study. Gut 47 : 618-621, 2000.
PubMed
4) Sekiguchi M, et al : Clinical outcomes and prognostic factors in gastric cancer patients aged ≧ 85 years undergoing endoscopic submucosal dissection. Gastrointest Endosc 85 : 963-972, 2017.
 
5) Kusano C, et al : Should elderly patients undergo additional surgery after non-curative endoscopic resection for early gastric cancer? Long-term comparative outcomes. Am J Gastroenterol 106 : 1064-1069, 2011.
PubMed
6) Hatta W, et al : Is radical surgery necessary in all patients who do not meet the curative criteria for endoscopic submucosal dissection in early gastric cancer? A multi-center retrospective study in Japan. J Gastroenterol 52 : 175-184, 2017.
 
7) Hatta W, et al : A Scoring System to Stratify Curability after Endoscopic Submucosal Dissection for Early Gastric Cancer : "eCura system". Am J Gastroenterol 112 : 874-881, 2017.
PubMed
8) Katai H, et al : Safety and feasibility of laparoscopy-assisted distal gastrectomy with suprapancreatic nodal dissection for clinical stage I gastric cancer : a multicenter phase II trial (JCOG O703). Gastric Cancer 13 : 238-244, 2010.
 
9) Inaki N, et al : A Multi-institutional, Prospective, Phase II Feasibility Study of Laparoscopy-Assisted Distal Gastrectomy with D2 Lymph Node Dissection for Locally Advanced Gastric Cancer (JLSSG0901). World J Surg 39 : 2734-2741, 2015.
PubMed
10) Zong L, et al : Feasibility of laparoscopic gastrectomy for elderly gastric cancer patients : meta-analysis of non-randomized controlled studies. Oncotarget 8 : 51878-51887, 2017.
PubMed
11) Mizuno A, et al : Lymphadenectomy along the infrapyloric artery may be dispensable when performing pylorus-preserving gastrectomy for early middle-third gastric cancer. Gastric Cancer 20 : 543-547, 2017.
PubMed
12) Goto O, et al : First case of non-exposed endoscopic wall-inversion surgery with sentinel node basin dissection for early gastric cancer. Gastric Cancer 18 : 434-439, 2015.
PubMed
13) Kitagawa Y, et al : Sentinel node mapping for gastric cancer : a prospective multicenter trial in Japan. J Clin Oncol 31 : 3704-3710, 2013.
PubMed
P.367 掲載の参考文献
1) Imperiale TF, et al : Multitarget stool DNA testing for colorectal-cancer screening ; N Engl J Med. 370 (14) : 1287-1297, 2014.
PubMed
2) Johnson DA, et al : Plasma Septin9 versus fecal immunochemical testing for colorectal cancer screening : a prospective multicenter study ; PLoS One. 9 (6) : e98238, 2014.
PubMed
3) 掛地吉弘 : National Clinical Database (消化器外科領域) Annual Report 2015 ; 日本消化器外科学会雑誌. 50 (2) : 166-176, 2017.
 
4) 川嶋太郎, ほか : 地方中核病院における80歳以上高齢者腹部緊急手術症例301例の検討 ; 日本腹部救急医学会雑誌 37 (4) : 537-541, 2017.
 
5) Copeland GP, et al : POSSUM : a scoring system for surgical audit. Br J Surg 78 : 356-360, 1991.
 
6) Tominaga T, et al : E-PASS score asa useful predictorof postoperative complications and mortality after colorectal surgery in elderly patients ; Int J Colorectal Dis 31 : 217-225, 2016.
 
7) Haga Y, et al : The EPOS-CC Score : An Integration of Independent, Tumor-and Patient-Associated Risk Factors to Predict 5-years Overall Survival Following Colorectal Cancer Surgery. World J Surg 39 : 1567-1577, 2015.
PubMed
8) 荒井秀典 (編) : フレイル診療ガイド 2018年版 (一般社団法人日本老年医学会, 国立研究開発法人国立長寿医療研究センター), ライフ・サイエンス, 2018.
 
9) サルコペニア診療ガイドライン作成委員会 (編) : サルコペニア診療ガイドライン 2017版 (一般社団法人日本サルコペニア・フレイル学会, 国立研究開発法人国立長寿医療研究センター), ライフ・サイエンス, 2017.
 
10) 日本老年医学会 (編) : 高齢者の安全な薬物療法ガイドライン 2015, メジカルビュー社 2015.
 
11) 三嶋秀行 : 高齢者に対する化学療法. 日本臨牀 73 (増 4) : 538-542, 2015.
 
12) NCCN Clinical Practice Guidelines in Oncology v2.2017 May 1, 2017
 
13) Munemoto Y, et al : Capecitabine and oxaliplatin combined with bevacizumab are feasible for treating selected Japanese patients at least 75 years of age with metastatic colorectal cancer. BMC Cancer 15 : 786, 2015.
PubMed
14) Denda T, et al : Pharmacokinetic dose adjustment of 5-FU in modified FOLFOX7 plus bevacizumab for metastatic colorectal cancer in Japanese patients : a-JUST phase II clinical trial. Cancer Chemother Pharmacol 78 : 1253-1261, 2016.
PubMed
15) Matsui T, et al : Bi-weekly Capecitabine-Oxaliplatin (XELOX) plus Bevacizumab as First-line Treatment of Metastatic Colorectal Cancer The PHOENiX Trial ; Anticancer Res 36 : 3437-3443, 2016.
PubMed
P.373 掲載の参考文献
1) Tsujita E, et al : Outcome of hepatectomy in hepatocellular carcinoma patients aged 80 years and older. Hepatogastroenterology 59 : 1553-1555, 2012.
PubMed
2) Ide T, et al : Prediction of postoperative complications in elderly patients with hepatocellular carcinoma. J Surg Res 185 : 614-619, 2013.
PubMed
3) Ueno M, et al : Recent trends in hepatectomy for elderly patients with hepatocellular carcinoma. Surg Today 44 : 1651-1659, 2014.
 
4) Taniai N, et al : Surgical outcomes and prognostic factors in elderly patients (75 years or older) with hepatocellular carcinoma who underwent hepatectomy. J Nippon Med Sch 80 : 426-432, 2013.
 
5) Yamada S, et al : Outcome of hepatectomy in super-elderly patients with hepatocellular carcinoma. Hepatol Res 42 : 454-458, 2012.
PubMed
6) Hirokawa F, et al : Surgical outcomes and clinical characteristics of elderly patients undergoing curative hepatectomy for hepatocellular carcinoma. J Gastrointest Surg 17 : 1929-1937, 2013.
PubMed
7) Wang WL, et al : Major hepatectomy is safe for hepatocellular carcinoma in elderly patients with cirrhosis. Eur J Gastroenterol Hepatol 26 : 444-451, 2014.
PubMed
8) Kaibori M, et al : Geriatric assessment as a predictor of postoperative complications in elderly patients with hepatocellular carcinoma. Langenbecks Arch Surg 401 : 205-214, 2016.
PubMed
9) Kaibori M, et al : Impact of Advanced Age on Survival in Patients Undergoing Resection of Hepatocellular Carcinoma : Report of a Japanese Nationwide Survey. Ann Surg, 2017. (doi : 10.1097/ SLA. 0000000000002526)
 
10) 高齢者のがんを考える会. [http://www.chotsg.com/jogo/] (2018年7月閲覧)
 
11) Kenis C, et al : Performance of two geriatric screening tools in older patients with cancer. J Clin Oncol 32 : 19-26, 2014.
 
P.376 掲載の参考文献
1) Uesaka K, et al : Adjuvant chemotherapy of S-1 versus gemcitabine for resected pancreatic cancer : a phase 3, open-label, randomised, non-inferiority trial (JASPAC 01). Lancet 388 : 248-257, 2016.
PubMed
2) Burris HA, et al : Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer : a randomized trial. J Clin Oncol 15 : 2403-2413, 1997.
 
3) Conroy T, et al : FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med 364 : 1817-1825, 2011.
PubMed
4) Von Hoff DD, et al : Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med 369 : 1691-1703, 2013.
PubMed
5) Yeo CJ, et al : Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma, part 2 : randomized controlled trial evaluating survival, morbidity, and mortality. Ann Surg 236 : 355-366 ; discussion 366-368, 2002.
 
6) 日本膵臓学会膵癌診療ガイドライン改訂委員会 (編) : 膵癌診療ガイドライン 2016年版, p96-100, 金原出版, 2016.
 
7) Sho M, et al : Prognosis after surgical treatment for pancreatic cancer in patients aged 80 years or older : a multicenter study. J Hepatobiliary Pancreat Sci 23 : 188-197, 2016.
 
8) Aoyama T, et al : Safety and feasibility of S-1 adjuvant chemotherapy for pancreatic cancer in elderly patients. Cancer Chemother Pharmacol 75 : 1115-1120, 2015.
PubMed
9) DiMagno EP, et al : AGA technical review on the epidemiology, diagnosis, and treatment of pancreatic ductal adenocarcinoma. American Gastroenterological Association. Gastroenterology 117 : 1464-1484, 1999.
PubMed
10) Okusaka T, et al : Phase II study of FOLFIRINOX for chemotherapy-nalve Japanese patients with metastatic pancreatic cancer. Cancer Sci 105 : 1321-1326, 2014.
 
11) Ueno H, et al : An early phase II study of S-1 in patients with metastatic pancreatic cancer. Oncology 68 : 171-178, 2005.
PubMed
12) Ueno H, et al : Randomized phase III study of gemcitabine plus S-1, S-1 alone, or gemcitabine alone in patients with locally advanced and metastatic pancreatic cancer in Japan and Taiwan : GEST study. J Clin Oncol 31 : 1640-1648, 2013.
PubMed
13) Imaoka H, et al : Clinical outcome of elderly patients with unresectable pancreatic cancer treated with gemcitabine plus S-1, S-1 alone, or gemcitabine alone : Subgroup analysis of a randomised phase III trial. GEST study. Eur J Cancer 54 : 96-103, 2016.
PubMed
P.381 掲載の参考文献
1) Davies DF, Shock NW : Age changes in glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in adult males. J Clin Invest 29 : 496-507, 1950.
 
2) Lindeman RD, et al : Longitudinal studies on the rate of decline in renal function with age. J Am Geriatr Soc 33 : 278-285, 1985.
 
3) Kaplan C, et al : Age-related incidence of sclerotic glomeruli in human kidneys. Am J Pathol 80 : 227-234, 1975.
PubMed
4) Tomida K, et al : Serum 25-hydroxyvitamin D as an independent determinant of 1-84 PTH and bone mineral density in non-diabetic predialysis CKD patients. Bone 44 : 678-683, 2009.
PubMed
5) Iseki K, et al : Risk of developing end-stage renal disease in a cohort of mass screening. Kidney Int 49 : 800-805, 1996.
 
6) Takazakura E, et al : Intrarenal vascular changes with age and disease. Kidney Int 2 : 224-230, 1972.
PubMed
7) Dontas AS, et al : Mechanisms of renal tubular defects in old age. Postgrad Med J 48 : 295-303, 1972.
PubMed
8) Crowe MJ, et al : Altered water excretion in healthy elderly men. Age Ageing 16 : 285-293, 1987.
PubMed
9) Ailabouni W, Eknoyan G : Nonsteroidal anti-inflammatory drugs and acute renal failure in the elderly. A risk-benefit assessment. Drugs Aging 9 : 341-351, 1996.
PubMed
10) Clark BA, et al : Increased susceptibility to thiazide-induced hyponatremia in the elderly. J Am Soc Nephrol 5 : 1106-1111, 1994.
PubMed
11) Abuelo JG : Normotensive ischemic acute renal failure. N Engl J Med 357 : 797-805, 2007.
PubMed
P.388 掲載の参考文献
1) 平成23年度厚生労働省腎疾患対策研究, CKDの早期発見・予防・治療標準化・進展阻止に関する研究班報告書, 2012年.
 
2) 日本腎臓学会 (編) : CKD診療ガイド 2012, 東京医学社, 2012.
 
3) Ibrahim HN, et al : Long-term consequences of kidney donation. N Engl J Med 360 : 459-469, 2009.
PubMed
4) Kido R, et al : Very low but stable glomerular filtration rate after living kidney donation : is the concept of "chronic kidney disease" applicable to kidney donors? Clin Exp Nephrol 14 : 356-362, 2010.
PubMed
5) Imai E, et al : Slower decline of glomerular filtration rate in the Japanese general population : a longitudinal 10-year follow-up study. Hypertens Res 31 : 433-441, 2008.
PubMed
6) Tomlinson LA, et al : Prevalence of ambulatory hypotension in elderly patients with CKD stages 3 and 4. Nephrol Dial Transplant 24 : 3751-3755, 2009.
PubMed
7) Yokota K, et al : Impact of visit-to-visit variability of blood pressure on deterioration of renal function in patients with non-diabetic chronic kidney disease. Hypertens Res 36 : 151-157, 2013.
PubMed
8) Uehara K, et al : Estimated Glomerular Filtration Rate Variability Independently Predicts Renal Prognosis in Advanced Chronic Kidney Disease Patients. Nephron 130 : 256-262, 2015.
PubMed
9) Odden MC, et al : Rethinking the association of high blood pressure with mortality in elderly adults : the impact of frailty. Arch Intern Med 172 : 1162-1168, 2012.
PubMed
10) SPRINT Research Group : A Randomized Trial of Intensive versus Standard Blood-Pressure Control. N Engl J Med 373 : 2103-2116, 2015.
 
11) Obi Y, et al : Estimated glomerular filtration rate and the risk-benefit profile of intensive blood pressure control amongst nondiabetic patients : apost hoc analysis of a randomized clinical trial. J Intern Med 283 : 314-327, 2018.
 
12) Brenner BM, et al : Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 345 : 861-869, 2001.
PubMed
13) de Zeeuw D, et al : Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy : lessons from RENAAL. Kidney Int 65 : 2309-2320, 2004.
PubMed
14) 今井圓裕, ほか : 第51回日本腎臓学会学術総会, 2008.
 
15) Wada T, et al : Clinical impact of albuminuria in diabetic nephropathy. Clin Exp Nephrol 16 : 96-101, 2012.
PubMed
16) O'Hare AM, et al : Current guidelines for using angiotensin-converting enzyme inhibitors and angiotensin II-receptor antagonists in chronic kidney disease : is the evidence base relevant to older adults? Ann Intern Med 150 : 717-724, 2009.
PubMed
17) O'Hare AM, et al : Interpreting treatment effects from clinical trials in the context of real-world risk information : end-stage renal disease prevention in older adults. JAMA Intern Med 174 : 391-397, 2014.
PubMed
18) Juurlink DN, et al : Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation Study. N Engl J Med 351 : 543-551, 2004.
PubMed
19) Rowe JW, Kahn RL : Successful aging. Gerontologist 37 : 433-440, 1997.
PubMed
20) Hiraki K, et al : Decreased physical function in pre-dialysis patients with chronic kidney disease. Clin Exp Nephrol 17 : 225-231, 2013.
PubMed
21) Yazawa M, et al : Early Mortality Was Highly and Strongly Associated with Functional Status in Incident Japanese Hemodialysis Patients : A Cohort Study of the Large National Dialysis Registry. PLoS One 11 : e0156951, 2016.
PubMed
22) Kurella Tamura M, et al : Functional status of elderly adults before and after initiation of dialysis. N Engl J Med 361 : 1539-1547, 2009.
PubMed
23) Wilhelm-Leen ER, et al : Frailty and chronic kidney disease : the Third National Health and Nutrition Evaluation Survey. Am J Med 122 : 664-671. e2, 2009.
 
24) Ikizler TA, et al : Spontaneous dietary protein intake during Progression of chronic renal failure. J Am Soc Nephrol 6 : 1386-1391, 1995.
PubMed
25) 厚生労働省 : 平成22年国民健康・栄養調査報告, 平成24年.
 
26) Levine ME, et al : Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab 19 : 407-417, 2014.
 
27) Hiraki K, et al : Dietary protein intake is strongly and positively related with muscle strength in patients with pre-dialysis chronic kidney disease. Clin Exp Nephrol 21 : 354-355, 2017.
PubMed
28) Kopple JD, et al : Exercise in maintenance hemodialysis patients induces transcriptional changes in genes favoring anabolic muscle. J Am Soc Nephrol 18 : 2975-2986, 2007.
PubMed
29) Fiatarone MA, et al : Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med 330 : 1769-1775, 1994.
PubMed
30) Hiraki K, et al : Effects of home-based exercise on pre-dialysis chronic kidney disease patients : a randomized pilot and feasibility trial. BMC Nephrol 18 : 198, 2017.
PubMed
31) Otobe Y, et al : Mild cognitive impairment in older adults with pre-dialysis patients with chronic kidney disease : Prevalence and association with physical function. Nephrology (Carlton), 2017. (doi : 10.1111/nep. 13173) [Epub ahead of print]
 
P.392 掲載の参考文献
1) Ishani A, et al : Acute kidney injury increases risk of ESRD among elderly. J Am Soc Nephrol 20 : 223-228, 2009.
PubMed
2) AKI (急性腎障害) 診療ガイドライン作成委員会 : AKI (急性腎障害) 診療ガイドライン 2016, 東京医学社, 2016.
 
3) Rule AD, et al : The association between age and nephrosclerosis on renal biopsy among healthy adults. Ann Intern Med 152 : 561-567, 2010.
PubMed
4) Samiy AH : Renal disease in the elderly. Med Clin North Am 67 : 463-480, 1983.
PubMed
5) Chaumont M, et al : Acute Kidney Injury in Elderly Patients With Chronic Kidney Disease : Do Angiotensin-Converting Enzyme Inhibitors Carry a Risk? JClin Hypertens (Greenwich) 18 : 514-521, 2016.
 
6) Mehran R, et al : A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention : development and initial validation. J Am Coll Cardiol 44 : 1393-1399, 2004.
PubMed
7) The Kidney Disease Improving Global Outcomes (KDIGO) Working Group : Summary of Recommendation Statements. Kidney Int Suppl (2011) 2 (1) : 8-12, 2012.
 
8) Liu S, et al : Application of continuous renal replacement therapy for acute kidney injury in elderly patients. Int J Clin Exp Med 8 : 9973-9978, 2015.
PubMed
9) Chima-Melton C, et al : The Impact of Race on Intensity of Care Provided to Older Adults in the Medical Intensive Care Unit. J Racial Ethn Health Disparities 3 : 365-372, 2016.
PubMed
10) Wilson FP, et al : Dialysis versus nondialysis in patients with AKI : a propensity-matched cohort study. Clin J Am Soc Nephrol 9 : 673-681, 2014.
 
P.397 掲載の参考文献
1) Beck LH, et al : M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med 361 : 11-21, 2009.
PubMed
2) Tomas NM, et al : Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy. N Engl J Med 371 : 2277-2287, 2014.
PubMed
3) Hunley TE, et al : Nephrotic syndrome complicating alpha-glucosidase replacement therapy for Pompe disease. Pediatrics 114 : e532-e535, 2004.
PubMed
4) Debiec H, et al : Allo-immune membranous nephropathy and recombinant aryl sulfatase replacement therapy : a need for tolerance induction therapy. J Am Soc Nephrol 25 : 675-680, 2014.
PubMed
5) Alexander MP, et al : Membranous glomerulonephritis is a manifestation of IgG4-related disease. Kidney Int 83 : 455-462, 2013.
PubMed
6) Yokoyama H, et al : Membranous nephropathy in Japan : analysis of the Japan Renal Biopsy Registry (J-RBR). Clin Exp Nephrol 16 : 557-563, 2012.
PubMed
7) Sugiyama H, et al : Japan Renal Biopsy Registry and Japan Kidney Disease Registry : Committee Report for 2009 and 2010. Clin Exp Nephrol 17 : 155-173, 2013.
PubMed
8) Beck LH Jr, Salant DJ : Membranous nephropathy : recent travels and new roads ahead. Kidney Int 77 : 765-770, 2010.
PubMed
9) Ponticelli C, et al : Glomerular diseases : membranous nephropathy--a modern view. Clin J Am Soc Nephrol 9 : 609-616, 2014.
PubMed
10) Fujimoto S, et al : Nephrotic syndrome caused by membranous nephropathy : response to a short course of cyclophosphamide alternating with prednisolone. Intern Med 43 : 30-34, 2004.
 
11) Jha V, et al : A randomized, controlled trial of steroids and cyclophosphamide in adults with nephrotic syndrome caused by idiopathic membranous nephropathy. J Am Soc Nephrol 18 : 1899-1904, 2007.
PubMed
12) エビデンスに基づくネフローゼ症候群診療ガイドライン 2014. 日本腎臓学会誌 56 (7), 2014.
 
13) Seitz-Polski B, et al : Epitope Spreading of Autoantibody Response to PLA2R Associates with Poor Prognosis in Membranous Nephropathy. J Am Soc Nephrol 27 : 1517-1533, 2016.
PubMed
P.402 掲載の参考文献
1) Fouque D, et al : A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease. Kidney Int 73 : 391-398, 2008.
PubMed
2) Yasui S, et al : Prevalence of protein-energy wasting (PEW) and evaluation of diagnostic criteria in Japanese maintenance hemodialysis patients. Asia Pac J Clin Nutr 25 : 292-299, 2016.
PubMed
3) Takahashi H, et al : Comparison of Nutritional Risk Scores for Predicting Mortality in Japanese Chronic Hemodialysis Patients. J Ren Nutr 27 : 201-206, 2017.
PubMed
4) Kanazawa Y, et al : Diagnosis and prevalence of protein-energy wasting and its association with mortality in Japanese haemodialysis patients. Nephrology (Carlton) 22 : 541-547, 2017.
PubMed
5) McIntyre CW, et al : Patients receiving maintenance dialysis have more severe functionally significant skeletal muscle wasting than patients with dialysis-independent chronic kidney disease. Nephrol Dial Transplant 21 : 2210-2216, 2006.
PubMed
6) Fahal IH, et al : Physiological abnormalities of skeletal muscle in dialysis patients. Nephrol Dial Transplant 12 : 119-127, 1997.
PubMed
7) Pupim LB, et al : Accelerated lean body mass loss in incident chronic dialysis patients with diabetes mellitus. Kidney Int 68 : 2368-2374, 2005.
PubMed
8) Yoowannakul S, et al : Differences in the prevalence of sarcopenia in haemodialysis patients : the effects of gender and ethnicity. J Hum Nutr Diet, 2018. (in press)
 
9) Kittiskulnam P, et al : Sarcopenia and its individual criteria are associated, in part, with mortality among patients on hemodialysis. Kidney Int 92 : 238-247, 2017.
PubMed
10) Chowdhury R, et al : Frailty and chronic kidney disease : A systematic review. Arch Gerontol Geriatr 68 : 135-142, 2017.
PubMed
11) Sezer S, et al : Long-term oral nutrition supplementation improves outcomes in malnourished patients with chronic kidney disease on hemodialysis. JPEN J Parenter Enteral Nutr 38 : 960-965, 2014.
PubMed
12) Weiner DE, et al : Oral intradialytic nutritional supplement use and mortality in hemodialysis patients. Am J Kidney Dis 63 : 276-285, 2014.
PubMed
13) Deger SM, et al : High dose omega-3 fatty acid administration and skeletal muscle protein turnover in maintenance hemodialysis patients. Clin J Am Soc Nephrol 11 : 1227-1235, 2016.
PubMed
14) Manfredini F, et al : Exercise in Patients on Dialysis : A Multicenter, Randomized Clinical Trial. J Am Soc Nephrol 28 : 1259-1268, 2017.
PubMed
15) Matsuzawa R, et al : Physical Activity Dose for Hemodialysis Patients : Where to Begin? Results from a Prospective Cohort Study. J Ren Nutr 28 : 45-53, 2018.
PubMed
P.408 掲載の参考文献
1) 総務省統計局 : 人口推計. [http://www.stat.go.jp/data/jinsui/] (2018年6月閲覧)
 
2) 内閣府 : 高齢社会白書. [http://www8.cao.go.jp/kourei/whitepaper/index-w.html] (2018年6月閲覧)
 
3) 厚生労働科学研究 : 健康寿命のページ. [http://toukei.umin.jp/kenkoujyumyou/] (2018年6月閲覧)
 
4) 国立社会保障・人口問題研究所. [http://www.ipss.go.jp/]
 
5) 日本老年学会・日本老年医学会「高齢者に関する定義検討ワーキンググループ」報告書, 2017.
 
6) 日本女性医学学会 (編) : 骨粗鬆症. 女性医学ガイドブック 更年期医療編 2014年版, p45-70, 金原出版, 2014.
 
7) 日本産科婦人科学会 (編) : 閉経後骨粗鬆症. 産婦人科研修の必須知識 2016-2018, p704-712, 日本産科婦人科学会, 2016.
 
8) Olsen AL, et al : Pelvic fioor nerve conduction studies : establishing clinically relevant normative data. Am J Obstet Gynecol 189 : 1114-1119, 2003.
PubMed
9) 日本産科婦人科学会 (編) : 排尿障害. 産婦人科研修の必須知識 2016-2018, 日本産科婦人科学会, p718-724, 2016.
 
10) 日本産科婦人科学会 (編) : 骨盤臓器脱. 産婦人科研修の必須知識 2016-2018, p725-732, 日本産科婦人科学会, 2016.
 
11) 性器脱・尿失禁の治療. 研修ノート No. 84, 日本産婦人科医会, 公益社団法人日本産科婦人科学会.
 
12) 日本女性医学学会 (編) : 女性医学ガイドブック 更年期医療編 2014年版, 金原出版, 2014.
 
13) Rossouw JE, et al ; Writing Group for the Women's Health Initiative Investigators : Risks and benefits of estrogen plus progestin in healthy postmenopausal women : principal results From the Women's Health Initiative randomized controlled trial. JAMA 288 : 321-333, 2002.
 
14) Henderson VW : Alzheimer's disease : review of hormone therapy trials and implications for treatment and prevention after menopause. J Steroid Biochem Mol Biol 142 : 99-106, 2014.
PubMed
15) Kurata K, et al : Surgical Apgar Score predicts 30-day morbidity in elderly patients who undergo non-laparoscopic gynecologic surgery : A retrospective analysis. Int J Surg 48 : 215-219, 2017.
PubMed
P.415 掲載の参考文献
1) 安井敏之 : 本邦女性における閉経年齢ならびに閉経に影響を与える要因-Japan Nurses' Health Studyから-. 日本女性医学学会雑誌 20 : 161-165, 2012.
 
2) Yasui T, et al : Factors associated with premature ovarian failure, early menopause and earlier onset of menopause in Japanese women. Maturitas 72 : 249-255, 2012.
PubMed
3) 安井敏之 : ホルモン補充療法か漢方療法か. 日本女性医学学会雑誌 22 : 252-257, 2015.
 
4) 清水重敬, 鈴木衛 : 更年期におけるめまい. ENTONI 151 : 20-26, 2013.
 
5) Matsuzaki K, et al : Associations of menopausal symptoms with job-related stress factors in nurses in Japan. Maturitas 79 : 77-85, 2014.
PubMed
6) Jewett PI, et al : Trends of postmenopausal estrogen plus progestin prevalence in the United States between 1970 and 2010. Obstet Gynecol 124 : 727-733, 2014.
PubMed
7) 日本産科婦人科学会・日本女性医学学会 (編) : ホルモン補充療法ガイドライン 2017年度版, p89-93, p140-143, 日本産科婦人科学会, 2017.
 
8) Canonico M, et al : Postmenopausal Hormone Therapy and Risk of Stroke : Impact of the Route of Estrogen Administration and Type of Progestogen. Stroke 47 : 1734-1741, 2016.
PubMed
9) Canonico M, et al : Postmenopausal hormone therapy and risk of idiopathic venous thromboembolism : result from the E3N cohort study. Arterioscler Thromb Vasc Biol 30 : 340-345, 2010.
PubMed
10) Lyytinen H, et al : Breast cancer risk in postmenopausal women using estradiol-progestogen therapy. Obstet Gynecol 113 : 65-73, 2009.
PubMed
11) Renoux C, et al : Hormone replacement therapy and the risk of venous thromboembolism : a population-based study. J Thrombo Haemost 8 : 979-986, 2010.
 
12) Mikkola TS, et al : Estradiol-based postmenopausal hormone therapy and risk of cardiovascular and all-cause mortality. Menopause 22 : 976-983, 2015.
PubMed
13) Smith NL, et al : Lower risk of cardiovascular events in postmenopausal women taking oral estradiol compared with oral conjugated equine estrogens. JAMA Intern Med 174 : 25-31, 2014.
PubMed
14) Jane FM, Davis SR : A practitioner's toolkit for managing the menopause. Climacteric 17 : 564-579, 2014.
PubMed
15) Matsuzaki K, et al : Differences in coping with menopausal symptoms in nurses and general workers in Japan. Maturitas 86 : 45-52, 2016.
PubMed
16) 安井敏之 : 周閉経期におけるエストロゲンとサイトカイン. 日本女性医学学会雑誌 20 : 78-85, 2012.
 
P.420 掲載の参考文献
1) Olsen AL, et al : Epidemiology of surgically managed pelvic organ prolapse and urinary incontinence. Obstet Gynecol 89 : 501-506, 1997.
PubMed
2) Hu TW, et al : Costs of urinary incontinence and overactive bladder in the United States : a comparative study. Urology 63 : 461-465, 2004.
PubMed
3) DeLancey JO : Functional anatomy of the female lower urinary tract and pelvic floor. Ciba Found Symp 151 : 57-69 ; discussion 69-76, 1990.
 
4) Bump RC, et al : The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction. Am J Obstet Gynecol 175 : 10-17, 1996.
PubMed
5) Patel DN, Anger JT : Surgery for pelvic organ prolapse. Curr Opin Urol 26 : 302-308, 2016.
PubMed
6) Liao YM, et al : Prevalence and impact on quality of life of lower urinary tract symptoms among a sample of employed women in Taipei : aquestionnaire survey. Int J Nurs Stud 46 : 633-644, 2009.
 
7) Homma Y, et al : Symptom assessment tool for overactive bladder syndrome--overactive bladder symptom score. Urology 68 : 318-323, 2006.
PubMed
8) Nilsson CG : Latest advances in TVT tension-free support for urinary incontinence. Surg Technol Int 12 : 171-176, 2004.
PubMed
9) Bolton JF, Harrison SC : Neuromodulation 10 years on : how widely should we use this technique in bladder dysfunction? Curr Opin Urol 19 : 375-379, 2009.
 
10) Bornstein J, et al : 2015 ISSVD, ISSWSH, and IPPS Consensus Terminology and Classification of Persistent Vulvar Pain and Vulvodynia. J Low Genit Tract Dis 20 : 126-130, 2016.
PubMed
11) Edwards L : Vulvodynia. Clin Obstet Gynecol 58 : 143-152, 2015.
PubMed
P.426 掲載の参考文献
1) 国立がん研究センターがん情報サービス [https://ganjoho.jp/public/cancer/index.html] (2018年6月閲覧)
 
2) ヒトパピローマウイルス (HPV) ワクチンに関するファクトシート (国立感染症研究所) [http://www.mhlw.go.jp/stf2/shingi2/2r9852000000bx23-att/2r9852000000byb3.pdf] (2018年6月閲覧)
 
3) 日本婦人科腫瘍学会 (編) : 子宮頸癌治療ガイドライン 2017年版, 金原出版, 2017.
 
4) 全がん協生存率 [http://www.zengankyo.ncc.go.jp/etc/seizonritsu/seizonritsu2009.html] (2018年7月閲覧)
 
5) Landoni F, et al : Randomised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer. Lancet 350 : 535-540, 1997.
PubMed
6) Toita T, et al : Prospective multi-institutional study of definitive radiotherapy with high-dose-rate intracavitary brachytherapy in patients with nonbulky ( < 4-cm) stage I and II uterine cervical cancer (JAROG0401/JROSG04-2). Int J Radiat Oncol Biol Phys 82 : e49-56, 2012.
 
7) Tewari KS, et al : Improved survival with bevacizumab in advanced cervical cancer. N Engl J Med 370 : 734-743, 2014.
PubMed
8) 日本婦人科腫瘍学会 (編) : 子宮体がん治療ガイドライン 2013年版, 金原出版, 2013.
 
9) Mourits MJ, et al : Safety of laparoscopy versus laparotomy in early-stage endometrial cancer : a randomised trial. Lancet Oncol 11 : 763-771, 2010.
PubMed
10) Walker JL, et al : Recurrence and survival after random assignment to laparoscopy versus laparotomy for comprehensive surgical staging of uterine cancer : Gynecologic Oncology Group LAP2 Study. J Clin Oncol 30 : 695-700, 2012.
PubMed
11) Knocke TH, et al : Primary treatment of endometrial carcinoma with high-dose-rate brachytherapy : results of 12 years of experience with 280 patients. Int J Radiat Oncol Biol Phys 37 : 359-365, 1997.
PubMed
P.432 掲載の参考文献
1) 独立行政法人国立がん研究センターがん対策情報センターがん情報サービス, 部位別がんの統計情報.
 
2) NCCN Clinical Practice Guidelines in Oncology for Senior Adult Oncology.
 
3) 長寿科学総合研究CGAガイドライン研究班, 鳥羽研二 (監修) : 高齢者総合的機能評価ガイドライン, 厚生科学研究所 2003.
 
4) Hurria A, et al : Developing a cancer-specific geriatric assessment : a feasibility study. Cancer 104 : 1998-2005, 2005.
PubMed
5) Extermann M, Hurria A : Comprehensive geriatric assessment for older patients with cancer. J Clin Oncol 25 : 1824-1831, 2007.
 
6) 大西明弘, 高齢者における薬物動態の特徴. 臨床薬理 39 : 2-5, 2008.
 
7) NCCN Clinical Practice Guidelines in Oncology, Version 2. 2017, Older Adult Oncology.
 
8) Sundararajan V, et al : Variations in the use of chemotherapy for elderly patients with advanced ovarian cancer : a population-based study. J Clin Oncol 20 : 173-178, 2002.
PubMed
9) Fairfield KM, et al : Completion of adjuvant chemotherapy and use of health services for older women with epithelial ovarian cancer. J Clin Oncol 29 : 3921-3926, 2011.
PubMed
10) Winter WE, et al : Prognostic factors for stage III epithelial ovarian cancer : a Gynecologic Oncology Group Study. J Clin Oncol 25 : 3621-3627, 2007.
 
11) Suh DH, et al : Management of the elderly patient with gynecologic cancer : report of the 2011 workshop in geriatric gynecologic oncology. Int J Gynecol Cancer 22 : 161-169, 2012.
PubMed
12) Hilpert F, et al : Feasibility, toxicity and quality of life of first-line chemotherapy with platinum/paclitaxel in elderly patients aged > or=70 years with advanced ovarian cancer a study by the AGO OVAR Germany. Ann Oncol 18 : 282-287, 2007.
PubMed
13) Eisenhauer EL, et al : Response and outcomes in elderly patients with stages IIIC-IV ovarian cancer receiving platinum-taxane chemotherapy. Gynecol Oncol 106 : 381-387, 2007.
PubMed
14) Trrdan O, et al : Carboplatin/cyclophosphamide or carboplatin/paclitaxel in elderly patients with advanced ovarian cancer? Analysis of two consecutive trials from the Groupe d'Investigateurs Nationaux pour l'Etude des Cancers Ovariens. Ann Oncol 18 : 256-262, 2007.
 
15) Fader AN, et al : Improved tolerance of primary chemotherapy with reduced-dose carboplatin and paclitaxel in elderly ovarian cancer patients. Gynecol Oncol 109 : 33-38, 2008.
PubMed
16) Matulonis UA, et al : Phase II prospective study of paclitaxel and carboplatin in older patients with newly diagnosed Mullerian tumors. Gynecol Oncol 112 : 394-399, 2009.
PubMed
17) Pignata S, et al : A phase II study of weekly carboplatin and paclitaxel as first-line treatment of elderly patients with advanced ovarian cancer. A Multicentre Italian Trial in Ovarian cancer (MITO-5) study. Crit Rev Oncol Hematol 66 : 229-236, 2008.
 
18) Bookman MA, et al : Evaluation of new platinum-based treatment regimens in advanced-stage ovarian cancer : a Phase III Trial of the Gynecologic Cancer Intergroup. J Clin Oncol 27 : 1419-1425, 2009.
PubMed
19) Tew WP, et al. Treatment outcornes for older women with advanced ovarian cancer : Results from a phase III clinical trial (GOG182). J Clin Oncol 28 (15 Suppl) : 5030, 2010.
 
20) Kurtz JE, et al : Ovarian cancer in elderly patients : carboplatin and pegylated liposomal doxorubicin versus carboplatin and paclitaxel in late relapse : a Gynecologic Cancer Intergroup (GCIG) CALYPSO sub-study. Ann Oncol 22 : 2417-2423, 2011.
PubMed
21) Aghajanian C, et al : OCEANS : a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer. J Clin Oncol 30 : 2039-2045, 2012.
 
P.436 掲載の参考文献
1) Stephenson GD, Rose DP : Breast cancer and obesity : an update. Nutr Cancer 45 : 1-16, 2003.
PubMed
2) Bulun SE, et al : Aromatase, breast cancer and obesity : a complex interaction. Trends Endocrinol Metab 23 : 83-89, 2012.
PubMed
3) Shlomai G, et al : Type 2 Diabetes Mellitus and Cancer : The Role of Pharmacotherapy. J Clin Oncol 34 : 4261-4269, 2016.
PubMed
4) Zakikhani M, et al : Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res 66 : 10269-10273, 2006.
PubMed
5) Partridge AH, et al : Subtype-Dependent Relationship Between Young Age at Diagnosis and Breast Cancer Survival. J Clin Oncol 34 : 3308-3314, 2016.
PubMed
6) de Glas NA, et al : Postoperative complications and survival of elderly breast cancer patients : a FOCUS study analysis. Breast Cancer Res Treat 138 : 561-569, 2013.
PubMed
7) Hind D, et al : Surgery versus primary endocrine therapy for operable primary breast cancer in elderly women (70 years plus). Cochrane Database Syst Rev (1) : CD004272, 2006.
PubMed
8) International Breast Cancer Study Group, et al : Randomized trial comparing axillary clearance versus no axillary clearance in older patients with breast cancer : first results of International Breast Cancer Study Group Trial 10-93. J Clin Oncol 24 : 337-344, 2006.
 
9) Prescott RJ, et al : A randomised controlled trial of postoperative radiotherapy following breast-conserving surgery in a minimum-risk older population. The PRIME trial. Health Technol Assess 11 : 1-149, iii-iv, 2007.
 
10) Albrand G, Terret C : Early breast cancer in the elderly : assessment and management considerations. Drugs Aging 25 : 35-45, 2008.
PubMed
11) Wildiers H, et al : Management of breast cancer in elderly individuals : recommendations of the International Society of Geriatric Oncology. Lancet Oncol 8 : 1101-1115, 2007.
PubMed
12) Muss HB, et al : Adjuvant chemotherapy in older women with early-stage breast cancer. N Engl J Med 360 : 2055-2065, 2009.
PubMed
13) Ladwa R, et al : Maintaining Dose Intensity of Adjuvant Chemotherapy in Older Patients With Breast Cancer. Clin Breast Cancer, 2018. (doi : 10.1016/j. clbc. 2018. 04. 016) [Epub ahead of print]
 
14) Kaufman PA, et al : Treatment patterns and clinical outcomes in elderly patients with HER2-positive metastatic breast cancer from the registHER observational study. Breast Cancer Res Treat 135 : 875-883, 2012.
PubMed
15) Sawaki M, et al : Evaluation of trastuzumab without chemotherapy as a post-operative adjuvant therapy in HER2-positive elderly breast cancer patients : randomized controlled trial〔RESPECT (NSAS BCO7) 〕. Jpn J Clin Oncol 41 : 709-712, 2011.
 
P.443 掲載の参考文献
1) 日本排尿機能学会 過活動膀胱診療ガイドライン作成委員会 : 過活動膀胱診療ガイドライン 第2版, リッチヒルメディカル, 2015.
 
2) Abrams P, et al : The standardisation of terminology of lower urinary tract function : report from the Standardisation Sub-committee of the International Continence Society. Neurourol Urodyn 21 : 167-178, 2002.
PubMed
3) Haylen BT, et al : An International Urogynecological Association (IUGA) /International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction. Neurourol Urodyn 29 : 4-20, 2010.
PubMed
4) 本間之夫, ほか ; 排尿に関する疫学的研究委員会 : 排尿に関する疫学的研究. 日本排尿機能学会誌 14 : 266-277, 2003.
Medical*Online
5) Burgio KL Update on behavioral and physical therapies for incontinence and overactive bladder : the role of pelvic floor muscle training. Curr Urol Rep 14 : 457-464, 2013.
PubMed
6) Abrams P, et al : Combination treatment with mirabegron and solifenacin in patients with overactive bladder : efficacy and safety results from a randomised, double-blind, dose-ranging, phase 2 study (Symphony). Eur Urol 67 : 577-588, 2015.
PubMed
7) Yamaguchi O, et al : Safety and efficacy of mirabegron as 'add-on' therapy in patients with overactive bladder treated with solifenacin : a post-marketing, open-label study in Japan (MILAI study). BJU Int 116 : 612-622, 2015.
 
8) Kaplan SA, et al : Antimuscarinics for treatment of storage lower urinary tract symptoms in men : a systematic review. Int J Clin Pract 65 : 487-507, 2011.
 
9) Siddiqui NY, et al : Efficacy and adverse events of sacral nerve stimulation for overactive bladder : A systematic review. Neurourol Urodyn 29 (Suppl 1) : S18-23, 2010.
 
10) Oerlemans DJ, van Kerrebroeck PE : Sacral nerve stimulation for neuromodulation of the lower urinary tract. Neurourol Urodyn 27 : 28-33, 2008.
PubMed
P.449 掲載の参考文献
1) 本間之夫, ほか : 排尿に関する疫学的研究. 日本排尿機能学会誌 14 : 266-277, 2003.
Medical*Online
2) Yamaguchi O, et al : Functional consequences of chronic bladder ischemia Neurourol Urodyn 33 : 54-58, 2014.
PubMed
3) 日本泌尿器科学会 : 男性下部尿路症状・前立腺肥大症診療ガイドライン, p2-5, リッチヒルメディカル, 2017.
 
4) 日本排尿機能学会 : 男性下部尿路症状診療ガイドライン, p40, ブラックウェルパブリッシング, 2008.
 
5) 日本排尿機能学会 : 夜間頻尿診療ガイドライン, p1-9, ブラックウェルパブリッシング, 2009,
 
P.455 掲載の参考文献
1) Tomlins SA, et al : Recurrent fusion of tMPRSS2 and ETS transcription factor genes in prostate cancer. Science 310 : 644-648, 2005.
PubMed
2) Laxman B, et al : Noninvasive detection of TMPRSS2 : ERG fusion transcripts in the urine of men with prostate cancer. Neoplasia 8 : 885-888, 2006.
PubMed
3) Sanda MG, et al : Association Between Combined TMPRSS2 : ERG and PCA3 RNA Urinary Testing and Detection of Aggressive Prostate Cancer. JAMA Oncol, 3 : 1085-1093, 2017.
PubMed
4) O'Malley PG, et al : Racial Variation in the Utility of Urinary Biomarkers PCA3 and T2ERG in a Large Multicenter Study. J Urol 198 : 42-49, 2017.
 
5) Miyagi Y, et al : ETS family-associated gene fusions in Japanese prostate cancer : analysis of 194 radical prostatectomy samples. Mod Pathol 23 : 1492-1498, 2010.
PubMed
6) McKiernan J, et al : A Novel Urine Exosome Gene Expression Assay to Predict High-grade Prostate Cancer at Initial Biopsy. JAMA Oncol 2 : 882-889, 2016.
PubMed
7) Rebbeck TR, et al : Association of HPC2/ELAC2 genotypes and prostate cancer. Am J Hum Genet 67 : 1014-1019, 2000.
PubMed
8) Tan SH : Prostate Cancer Genomics : Recent Advances and the Prevailing Underrepresentation from Racial and Ethnic Minorities. Int J Mol Sci 19 : E1255, 2018.
 
9) Casey G, et al : RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases. Nat Genet 32 : 581-583, 2002.
PubMed
10) Xu J, et al : Linkage and association studies of prostate cancer susceptibility : evidence for linkage at 8p22-23. Am J Hum Genet 69 : 341-350, 2001.
PubMed
11) Xu J, et al : Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. Nat Genet 32 : 321-325, 2002.
PubMed
12) Ewing CM, et al : Germline mutations in HOXB13 and prostate-cancer risk. N Engl J Med 366 : 141-149, 2012.
 
13) Laitinen VH, et al : HOXB13 G84E mutation in Finland : population-based analysis of prostate, breast, and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev 22 : 452-460, 2013.
PubMed
14) Lin X, et al : A novel germline mutation in HOXB13 is associated with prostate cancer risk in Chinese men. Prostate 73 : 169-175, 2013.
 
15) Karlsson R, et al : A population-based assessment of germline HOXB13 G84E mutation and prostate cancer risk. Eur Urol 65 : 169-176, 2014.
 
16) Thompson D, Easton DF : Cancer Incidence in BRCAI mutation carriers. J Natl Cancer Inst 94 : 1358-1365, 2002.
 
17) Agalliu I, et al : Associations of high-grade prostate cancer with BRCA1 and BRCA2 founder mutations. Clin Cancer Res 15 : 1112-1120, 2009.
PubMed
18) Leao RRN, et al : Germline BRCA mutation in male carriers-ripe for precision oncology? Prostate Cancer Prostatic Dis 21 : 48-56, 2018.
PubMed
19) Win AK, et al : Risks of primary extracolonic cancers following colorectal cancer in lynch syndrome. J Natl Cancer Inst 104 : 1363-1372, 2012.
PubMed
20) Berger MF, et al : The genomic complexity of primary human prostate cancer. Nature 470 : 214-220, 2011.
PubMed
21) Cancer Genome Atlas Research Network : The Molecular Taxonomy of Primary Prostate Cancer. Cell 163 : 1011-1025, 2015.
 
22) Robinson D, et al : Integrative clinical genomics of advanced prostate cancer. Cell 161 : 1215-1228, 2015.
PubMed
23) Wyatt AW, et al : Concordance of Circulating Tumor DNA and Matched Metastatic Tissue Biopsy in Prostate Cancer. J Natl Cancer Inst 110 : 78-86, 2018.
 
24) Bryce AH, et al : Androgen receptor splice variant 7 in castration-resistant prostate cancer : Clinical considerations. Int J Urol 23 : 646-653, 2016.
PubMed
25) Antonarakis ES, et al : Androgen receptor variant-driven prostate cancer : clinical implications and therapeutic targeting. Prostate Cancer Prostatic Dis 19 : 231-241, 2016.
 
26) Hu R, et al : Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer. Cancer Res 69 : 16-22, 2009.
PubMed
27) Li Y, et al : Androgen receptor splice variants mediate enzalutamide resistance in castrationresistant prostate cancer cell lines. Cancer Res 73 : 483-489, 2013.
PubMed
28) Mostaghel EA, et al : Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer : induction of steroidogenesis and androgen receptor splice variants. Clin Cancer Res 17 : 5913-5925, 2011.
PubMed
29) Hornberg E, et al : Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival. PLoS One 6 : e19059, 2011.
PubMed
30) Antonarakis ES, et al : AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer. N Engl J Med 371 : 1028-1038, 2014.
PubMed
31) Nakazawa M, et al : Serial blood-based analysis of AR-V7 in men with advanced prostate cancer. Ann Oncol 26 : 1859-1865, 2015.
PubMed
32) Li H, et al : Androgen-receptor splice variant-7-positive prostate cancer : a novel molecular subtype with markedly worse androgen-deprivation therapy outcomes in newly diagnosed patients. Mod Pathol 31 : 198-208, 2018.
PubMed
33) Mateo J, et al : DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer. N Engl J Med 373 : 1697-1708, 2015.
PubMed
P.461 掲載の参考文献
1) 国立がん研究センターがん情報サービス, 癌登録・統計. [https://ganjoho.jp/reg_stat/statistics/stat/summary.html] (2018年6月閲覧)
 
2) Mohr DN, et al : Asymptomatic microhematuria and urologic disease. A population-based study. JAMA 256 : 224-229, 1986.
PubMed
3) 松山豪泰 : 尿中細胞を用いた膀胱癌診断. 泌尿器外科 28, 363-366, 2015.
Medical*Online
4) Sokolova IA, et al : The development of a multitarget, multicolor fluorescence in situ hybridization assay for the detection of urothelial carcinoma in urine. J Mol Diagn 2 : 116-123, 2000.
PubMed
5) Matsuyama H, et al : Copy number aberrations using multicolour fluorescence in situ hybridization (FISH) for prognostication in non-muscle-invasive bladder cancer (NIMBC). BJU Int 113 : 662-667, 2014.
PubMed
6) Mengual L, et al : Clinical utility offluorescent in situ hybridization for the surveillance of bladder cancer patients treated with bacillus Calmette-Guerin therapy. Eur Urol 52 : 752-759, 2007.
 
7) Malik Z, et al : Destruction of erythroleukaemic cells by photoactivation of endogenous porphyrins. Br J Cancer 56 : 589-595, 1987.
PubMed
8) Hall MC, et al : Guideline for the management of nonmuscle invasive bladder cancer (stages Ta, T1, and Tis) : 2007 update. J Urol 178 : 2314-2330, 2007.
PubMed
9) Babjuk M, et al : EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder : update 2013. Eur Urol 64 : 639-653, 2013.
PubMed
10) Geavlete B, et al : Narrow-band imaging cystoscopy in non-muscle-invasive bladder cancer : a prospective comparison to the standard approach. Ther Adv Urol 4 : 211-217, 2012.
 
11) Menon M, et al : Nerve-sparing robot-assisted radical cystoprostatectomy and urinary diversion. BJU Int 92 : 232-236, 2003.
PubMed
12) Tang K, et al : Robotic vs. open radical cystectomy in bladder cancer : A systematic review and metaanalysis. Eur J Surg Oncol 40 : 1399-1411, 2014.
PubMed
13) Hanna N, et al : Comparative effectiveness of robot-assisted vs. open radical cystectomy. Urol Oncol 36 : 88.e1-88.e9, 2018.
 
14) Kulkarni GS, et al : Propensity Score Analysis of Radical Cystectomy Versus Bladder-Sparing Trimodal Therapy in the Setting of a Multidisciplinary Bladder Cancer Clinic. J Clin Oncol 35 : 2299-2305, 2017.
PubMed
15) Nagao K, et al : The Efficacy of Trimodal Chemoradiotherapy with Cisplatin as a Bladder-Preserving Strategy for the Treatment of Muscle-Invasive Bladder Cancer. Urol Int 99 : 446-452, 2017.
PubMed
16) Hara T, et al : Primary cT2 bladder cancer : a good candidate for radiotherapy combined with cisplatin for bladder preservation. Jpn J Clin Oncol 41 : 902-907, 2011.
PubMed
17) Kitamura H, et al : Paclitaxel, ifosfamide, and nedaplatin as second-line treatment for patients with metastatic urothelial carcinoma : a phase II study of the SUOC group. Cancer Sci 102 : 1171-1175, 2011.
PubMed
18) Kobayashi K, et al : Clinical significance of a second-line chemotherapy regimen with paclitaxel, ifosfamide and nedaplatin for metastatic urothelial carcinoma after failure of cisplatin-based chemotherapy. JPn J Clin Oncol 46 : 775-780, 2016.
PubMed
19) Bellmunt J, et al : Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma. N Engl J Med 376 : 1015-1026, 2017.
PubMed
20) Powles T, et al : Atezolizumab versus chemotherapy in patients with platinum-treated locally advanced or metastatic urothelial carcinoma (IMvigor211) : a multicentre, open-label, phase 3 randomised controlled trial. Lancet 391 : 748-757, 2018.
 
21) Petrylak DP, et al : Rarnucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE) : a randomised, double-blind, phase 3 trial. Lancet 390 : 2266-2277, 2017.
 
22) Choi W, et al : Identification of distinct basal and luminal subtypes of muscle-invasive bladder cancer with different sensitivities to frontline chemotherapy. Cancer Cell 25 : 152-165, 2014.
PubMed
23) Choi W, et al : Genetic Alterations in the Molecular Subtypes of Bladder Cancer : Illustration in the Cancer Genome Atlas Dataset. Eur Urol 72 : 354-365, 2017.
 
24) Seiler R, et al : Impact of molecular subtypes in muscle-invasive bladder cancer on predicting response and survival after neoadjuvant chemotherapy. Eur Urol 72 : 544-554, 2017.
PubMed
25) Todenh6fer T, et al : Liquid Biopsy-Analysis of Circulating Tumor DNA (ctDNA) in Bladder Cancer. Bladder Cancer 4 : 19-29, 2018.
 
26) Lee SH, et al : Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer. Cell 173 : 515-528. e17, 2018.
 
P.466 掲載の参考文献
1) Marumo K et al : Prevalence of renal cell carcinoma : a nation-wide survey in Japan, 2002, Int J Urol 14 : 479-482, 2007.
PubMed
2) Outline of Vital Statistics in Japan. [http://www.mhlw.go.jp/english/database/db-hw/vs01.html] (2018年6月閲覧)
 
3) Droz Jp, et al : Management of prostate cancer in older men : recommendations of a working group of the International Society of Geriatric Oncology. BJU Int 106 : 462-469, 2010.
 
4) 腎癌診療ガイドライン 2017年版 (日本泌尿器科学会編), メディカルレビュー社, 2017. [http://www.urol.or.jp/info/guideline/data/guideline_list_180502.pdf.] (2018年6月閲覧)
 
5) May M, et al : Results of a comparative study analyzing octogenarians with renal cell carcinoma in a competing risk analysis with patients in the seventh decade of life. Urol Oncol 32 : 1252-1258, 2014.
 
6) Brassart E, et al : Overall mortality after radical nephrectomy in patients aged over 80 years with renal cancer : a retrospective study on preoperative prognostic factors. Int J Urol 19 : 626-632, 2012.
 
7) Kim SP, Thompson RH : Approach to the small renal mass : to treat or not to treat. Urol Clin North Am 39 : 171-179, vi, 2012.
PubMed
8) Ljungberg B, et al : EAU guidelines on renal cell carcinoma : 2014 update. Eur Urol 67 : 913-924, 2015.
PubMed
9) Lane BR, et al : Active treatment of localized renal tumors may not impact overall survival in patients aged 75 years or older. Cancer 116 : 3119-3126, 2010.
 
10) Sun M, et al : Management of localized kidney cancer : calculating cancer-specific mortality and competing risks of death for surgery and nonsurgical management. Eur Urol 65 : 235-241, 2014.
 
11) Pierorazio PM, et al : Five-year analysis of a multi-institutional prospective clinical trial of delayed intervention and surveillance for small renal masses : the DISSRM registry. Eur Urol 68 : 408-415, 2015.
PubMed
12) Smaldone MC, et al : Small renal masses progressing to metastases under active surveillance : a systematic review and pooled analysis. Cancer 118 : 997-1006, 2012.
PubMed
13) Matsumoto R, et al : RENAL nephrometry score is a predictive factor for the annual growth rate of renal mass. Int J Urol 21 : 549-552, 2014.
PubMed
14) El Dib R, et al : Cryoablation vs radiofrequency ablation for the treatment of renal cell carcinoma : a meta-analysis of case series studies. BJU Int 110 : 510-516, 2012.
PubMed
15) Olweny EO, et al : Radiofrequency ablation versus partial nephrectomy in patients with solitary clinical Tla renal cell carcinoma : comparable oncologic outcomes at a minimum of 5 years of follow-up. Eur Urol 61 : 1156-1161, 2012.
 
16) Khambati HK, et al : Efficacy of targeted therapy for metastatic renal cell carcinoma in the elderly patient population. Clin Genitourin Cancer 12 : 354-358, 2014.
PubMed
17) Hurria A, et al : Senior adult oncology, version 2. 2014 : clinical practice guidelines in oncology. J Natl Compr Canc Netw 12 : 82-126, 2014.
PubMed
18) Audisio RA, et al : The surgical management of elderly cancer patients : recommendations of the SIOG surgical task force. Eur J Cancer 40 : 926-938, 2004.
PubMed
19) Gajra A, et al : Comprehensive Geriatric Assessment-Guided Therapy Does Improve Outcomes of Older Patients With Advanced Lung Cancer. J Clin Oncol 34 : 4047-4048, 2016.
PubMed
20) 宮島直人 : 第81回泌尿器科学会東部総会シンポジウム「高齢者泌尿器癌医療の課題と戦略」2016. [http://www2.convention.co.jp/ejua81/program/index.html] (2018年6月閲覧).
 
P.471 掲載の参考文献
1) Garfin SR, et al : New technologies in spine : kyphoplasty and vertebroplasty for the treatment of painful osteoporotic compression fractures. Spine 26 : 1511-1515, 2001.
PubMed
2) Wardlaw D, et al : Efficacy and safety of balloon kyphoplasty compared with non-surgical care for vertebral compression fracture (FREE) : a randomised controlled trial. Lancet 373 : 1016-1024, 2009.
 
3) Svedbom A, et al : Balloon kyphoplasty compared to vertebroplasty and nonsurgical management in patients hospitalized with acute osteoporotic vertebral compression fracture : a UK costeffectiveness analysis. Osteoporos Int 24 : 355-367, 2013.
PubMed
4) Glassman SD, et al : Correlation of radiographic parameters and clinical symptoms in adult scoliosis. Spine 30 : 682-688, 2005.
PubMed
5) Miyakoshi N, et al : Impact of spinal kyphosis on gastroesophageal refiux disease symptoms in patients with osteoporosis. Osteoporos Int 20 : 1193-1198, 2009.
 
6) Schwab F, et al : Adult spinal deformity-postoperative standing imbalance : how much can you tolerate? An overview of key parameters in assessing alignment and planning corrective surgery. Spine 35 : 2224-2231, 2010.
PubMed
7) Schwab F, et al : Scoliosis Research Society-Schwab adult spinal deformity classification : a validation study. Spine 37 : 1077-1082, 2012.
PubMed
P.477 掲載の参考文献
1) ロコモチャレンジ! 推進協議会 : 日本整形外科学会ロコモパンフレット 2015. [https://locomo-joa.jp/news/upload_images/locomo_pf2015.pdf] (2018年6月閲覧)
 
2) 厚生労働省平成28年 国民生活基礎調査の概況 : [http://www.mhlw.go.jp/toukei/saikin/hw/k-tyosa/k-tyosa16/] (2018年6月閲覧)
 
3) Yoshimura N, et al : Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women : the research on osteoarthritis/osteoporosis against disability study. J Bone Miner Metab 27 : 620-628, 2009.
PubMed
4) Yoshimura N, et al : Cohort profile : research on Osteoarthritis/Osteoporosis Against Disability study. Int J Epidemiol 39 : 988-995, 2010.
PubMed
5) Muraki S, et al : Prevalence of radiographic lumbar spondylosis and its association with low back pain in elderly subjects of population-based cohorts : the ROAD study. Ann Rheum Dis 68 : 1401-1406, 2009.
PubMed
6) Muraki S, et al : Prevalence of radiographic knee osteoarthritis and its association with knee pain in the elderly of Japanese population-based cohorts : the ROAD study. Osteoarthr Cartil 17 : 1137-1143, 2009.
 
7) Iidaka T, et al : Prevalence of radiographic hip osteoarthritis and its association with hip pain in Japanese men and women : the ROAD study. Osteoarthr Cartil 24 : 117-123, 2016.
 
8) Yoshimura N, et al. Epidemiology of the locomotive syndrome : The research on osteoarthritis/osteoporosis against disability study 2005-2015. Mod Rheumatol 27 : 1-7, 2017.
PubMed
P.483 掲載の参考文献
1) Nakamura M, et al : Prevalence and characteristics of chronic musculoskeletal pain in Japan. J Orthop Sci 16 : 424-432, 2011.
PubMed
2) Yoshimura N, et al : Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women : the research on osteoarthritis/osteoporosis against disability study. J Bone Miner Metab 27 : 620-628, 2009.
PubMed
3) Kuettner K, Goldberg VM (ed) : Osteoarthritic Disorders, p xxi-v, American Academy of Orthopaedic Surgeons, Rosemont, 1995.
 
4) Julius D, Basbaum AI : Molecular mechanisms of nociception. Nature 413 : 203-210, 2001.
PubMed
5) Fingleton C, et al : Pain sensitization in people with knee osteoarthritis : a systematic review and meta-analysis. Osteoarthr Cartil 23 : 1043-1056, 2015.
 
6) Thakur M, et al : Osteoarthritis pain : nociceptive or neuropathic? Nat Rev Rheumatol 10 : 374-380, 2014.
PubMed
7) Cottam WJ, et al : Associations of limbic-affective brain activity and severity of ongoing chronic arthritis pain are explained by trait anxiety. Neuroimage Clin 12 : 269-276, 2016.
PubMed
8) Zhang W, et al : OARSI recommendations for the management of hip and knee osteoarthritis : part III : Changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis Cartilage 18 : 476-499, 2010.
PubMed
9) Zibellini J, et al : Effect of diet-induced weight loss on muscle strength in adults with overweight or obesity-a systematic review and meta-analysis of clinical trials. Obes Rev 17 : 647-663, 2016.
PubMed
10) Brosseau L, et al : The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis, Part three : aerobic exercise programs. Clin Rehabil 31 : 612-624, 2017.
PubMed
11) Brosseau L, et al : The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis. Part two : strengthening exercise programs. Clin Rehabil 31 : 596-611, 2017.
PubMed
12) 日本整形外科学会 (訳) : 変形性膝関節症の管理に関するOARSI勧告-OARSIによるエビデンスに基づくエキスパートコンセンサスガイドライン (日本整形外科学会変形性膝関節症診療ガイドライン策定委員会による適合化終了版), 2015.
 
13) McAlindon TE, et al : OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthr Cartil 22 : 363-388, 2014.
 
14) 日本腎臓学会 (編) : エビデンスに基づくCKDガイドライン, 東京医学社, 2013.
 
15) Antman EM, et al : Use of nonsteroidal antiinflammatory drugs : an update for clinicians : a scientific statement from the American Heart Association. Circulation 115 : 1634-1642, 2007.
PubMed
16) American Geriatrics Society Panel on Pharmacological Management of Persistent Pain in Older Persons : Pharmacological management of persistent pain in older persons. J Am Geriatr Soc 57 : 1331-1346, 2009.
 
17) Makris UE, et al : Management of persistent pain in the older patient : a clinical review. JAMA 312 : 825-836, 2014.
 
18) Maheu E, et al : Efficacy and safety of hyaluronic acid in the management of osteoarthritis : Evidence from real-life setting trials and surveys. Semin Arthritis Rheum 45 (4 Suppl) : S28-33, 2016.
 
19) Juni P, et al : Intra-articular corticosteroid for knee osteoarthritis. Cochrane Database Syst Rev. (10) : CD005328, 2015.
PubMed
20) 本間哲夫, ほか : 変形性膝関節症に対するノイロトロピン (R) 錠の臨床評価 多施設共同研究. 医学と薬学 23 (2) : 445-453, 1990.
Medical*Online
21) デュロキセチン塩酸塩カプセル添付文書 [http://database.japic.or.jp/pdf/newPINS/00058451.pdf]
 
22) American Academy of Orthopaedic Surgeons. Treatment of osteoarthritis of the knee. Evidencebased guideline, 2nd edition, 2013. [https://www.aaos.org/cc_files/aaosorg/research/guidelines/treatmentofosteoarthritisofthekneeguideline.pdf] (2018年5月閲覧)
 
P.489 掲載の参考文献
1) 日本整形外科学会 : 腰痛診療ガイドライン 2012, 南江堂, 2012.
 
P.494 掲載の参考文献
1) 杉原毅彦 : 高齢者のリウマチ・膠原病の疫学. 臨床雑誌内科 115 : 357-361, 2015.
 
2) 杉原毅彦 : 高齢者医療ハンドブック-免疫機能. 臨床雑誌内科 121 : 606-609, 2018.
 
3) 杉原毅彦 : 巨細胞性動脈炎 (血管炎の臨床 UPDATE). 医学のあゆみ 263 : 491-494, 2017.
 
4) 杉原毅彦 : 薬物療法総論. 最新医学別冊新しい診断と治療のABC 81/免疫 7. 多発性筋炎・皮膚筋炎 : 147-154, 2014.
 
P.498 掲載の参考文献
1) MacGregor AJ, et al : Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis Rheum 43 : 30-37, 2000.
PubMed
2) Terao C, et al : A twin study of rheumatoid arthritis in the Japanese population. Mod Rheumatol 26 : 685-689, 2016.
PubMed
3) Deighton CM, et al : The contribution of HLA to rheumatoid arthritis. Clin Genet 36 : 178-182, 1989.
PubMed
4) Okada Y, et al : Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. Nat Genet 44 : 511-516, 2012.
PubMed
5) Sparks JA, et al : Associations of Smoking and Age With Inflammatory Joint Signs Among Unaffected First-Degree Relatives of Rheumatoid Arthritis Patients : Results From Studies of the Etiology of Rheumatoid Arthritis. Arthritis Rheumatol 68 : 1828-1838, 2016.
PubMed
6) Smolen JS, et al : EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs : 2013 update. Ann Rheum Dis 73 : 492-509, 2014.
PubMed
7) Ghoreschi K, Gadina M : Jakpot! New small molecules in autoimmune and inflammatory diseases. Exp Dermatol 23 : 7-11, 2014.
PubMed
8) Yamanaka H, et al : Tofacitinib, an oral Janus kinase inhibitor, as monotherapy or with background methotrexate, in Japanese patients with rheumatoid arthritis : an open-label, long-term extension study. Arthritis Res Ther 18 : 34, 2016.
 
9) Vincent A, et al : Beyond pain in fibromyalgia : insights into the symptom of fatigue. Arthritis Res Ther 15 : 221, 2013.
PubMed
10) Heinimann K, et al : Long-term increase of radiographic damage and disability in patients with RA in relation to disease duration in the era of biologics. Results from the SCQM cohort. J Clin Med 7 : E57, 2018.
 
11) van Tuyl LH, et al : The patient perspective on absence of disease activity in rheumatoid arthritis : a survey to identify key domains of patient-perceived remission. Ann Rheum Dis 76 : 855-861, 2017.
PubMed
12) Zink A, Albrecht K : Rheumatoid arthritis : The benefits of early treatment after decades. Nat Rev Rheumatol 13 : 458-459, 2017.
PubMed
13) Momohara S, et al : Recent trends in orthopedic surgery aiming to improve quality of life for those with rheumatoid arthritis : data from a large observational cohort. J Rheumatol 41 : 862-866, 2014.
PubMed
14) Ishikawa H, et al : Overall benefits provided by orthopedic surgical intervention in patients with rheumatoid arthritis. Mod Rheumatol, 2018. (doi : 10.1080/14397595. 2018.1457468) [Epub ahead of print]
 
15) Goodman SM, et al : 2017 American College of Rheumatology/American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients With Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty. Arthritis Rheumatol 69 : 1538-1551, 2017.
PubMed
16) Sugihara T, Harigai M : Targeting Low Disease Activity in Elderly-Onset Rheumatoid Arthritis : Current and Future Roles of Biological Disease-Modifying Antirheumatic Drugs. Drugs Aging 33 : 97-107, 2016.
PubMed
P.503 掲載の参考文献
1) Salvarani C, et al : Polymyalgia rheumatica and giant-cell arteritis. Lancet 372 : 234-245, 2008.
PubMed
2) Muller S, et al : Is cancer associated with polymyalgia rheumatica? Acohort study in the General Practice Research Database. Ann Rheum Dis 73 : 1769-1773, 2014.
 
3) Mackie SL, et al : Whole-body MRI of patients with polymyalgia rheumatica identifies a distinct subset with complete patient-reported response to glucocorticoids. Ann Rheum Dis 74 : 2188-2192, 2015.
PubMed
4) Salvarani C, et al : Clinical features of polymyalgia rheumatica and giant cell arteritis. Nat Rev Rheumatol 8 : 509-521, 2012.
PubMed
5) 杉原毅彦 : リウマチ性多発筋痛症. 日本内科学会雑誌 106 : 2125-2130, 2017.
 
6) 杉原毅彦 : リウマチ性多発筋痛症の分類基準と診療ガイドラインについて. 老年医学 54 : 867-871, 2016.
Medical*Online
7) Dasgupta B, et al : 2012 Provisional classification criteria for polymyalgia rheumatica : a European League Against Rheumatism/American College of Rheumatology collaborative initiative. Arthritis Rheum 64 : 943-954, 2012.
PubMed
8) Dejaco C, et al : 2015 Recommendations for the management of polymyalgia rheumatica : a European League Against Rheumatism/American College of Rheumatology collaborative initiative. Ann Rheum Dis 74 : 1799-1807, 2015.
PubMed
9) 杉原毅彦 : 巨細胞性動脈炎 (血管炎の臨床 UPDATE). 医学のあゆみ 263 : 491-494, 2017.
 
P.510 掲載の参考文献
1) Tsuboi H, et al : Primary and secondary surveys on epidemiology of Sjogren's syndrome in Japan. Mod Rheumatol 24 : 464-470, 2014.
PubMed
2) Sumida T, et al : The role of M3 muscarinic acetylcholine receptor reactive T cells in Sjogren's syndrome : a critical review. J Autoimmun 51 : 44-50, 2014.
PubMed
3) Iizuka M, et al : Pathogenic role of immune response to M3 muscarinic acetylcholine receptor in Sjogren's syndrome-like sialoadenitis. J Autoimmun 35 : 383-389, 2010.
PubMed
4) Iizuka M, et al : The crucial roles of IFN-Y in the development of M3 muscarinic acetylcholine receptor induced Sjogren's syndrome-like sialadenitis. Mod Rheumatol 23 : 614-616, 2013.
 
5) Iizuka M, et al : M3 muscarinic acetylcholine receptor reactive IL-17 producing T cells promotes development of Sjogren's syndrome like sialadenitis. Mod Rheumatol 25 : 158-160, 2015.
PubMed
6) Nitta T, et al : Human thymoproteasome variations influence CD8 T cell selection. Sci Immunol 2 : eaan5165, 2017. (doi : 10.1126/sciimmunol. aan5165)
 
7) Seror R, et al : Tolerance and efficacy of rituximab and changes in serum B cell biomarkers in patients with systemic complications of primary Sjogren's syndrome. Ann Rheum Dis 66 : 351-357, 2007.
PubMed
8) Adler S, et al : Evaluation of histologic, serologic, and clinical changes in response to abatacept treatment of primary Sjogren's syndrome : a pilot study. Arthritis Care Res (Hoboken) : 65 : 1862-1868, 2013.
PubMed
9) Meiners PM, et al : Abatacept treatment reduces disease activity in early primary Sjogren's syndrome (open-label proof of concept ASAP study). Ann Rheum Dis 73 : 1393-1396, 2014.
PubMed
10) Tsuboi H, et al : Efficacy and safety of abatacept for patients with Sjogren's syndrome associated with rheumatoid arthritis : rheumatoid arthritis with orencia trial toward Sjogren's syndrome Endocrinopathy (ROSE) trial-an open-label, one-year, prospective study-Interim analysis of 32 patients for 24 weeks. Mod Rheumatol 25 : 187-193, 2015.
PubMed
11) Tsuboi H, et al : Effectiveness of abatacept for patients with Sjogren's syndrome associated with rheumatoid arthritis. An open label, multicenter, one-year, prospective study : ROSE (Rheumatoid Arthritis with Orencia Trial toward Sjogren's syndrome Endocrinopathy) trial. Mod Rheumatol 26 : 891-899, 2016.
PubMed
12) Asashima H, et al : The anergy induction of M3 muscarinic acetylcholine receptor-reactive CD4+ T cells suppresses experimental sialadenitis-like Sjogren's syndrome. Arthritis Rheumatol 67 : 2213-2225, 2015.
PubMed
13) Iizuka-Koga M, et al : Functional Analysis of Dendritic Cells Generated from T-iPSCs from CD4+ T Cell Clones of Sjogren's Syndrome. Stem Cell Reports 8 : 1155-1163, 2017.
 
P.517 掲載の参考文献
1) Yamawaki M, et al : Changes in prevalence and incidence of Parkinson's disease in Japan during a quarter of a century. Neuroepidemiology 32 : 263-269, 2009.
PubMed
2) Kalia LV, et al : Parkinson's disease. Lancet 386 : 896-912, 2015.
PubMed
3) Hely MA, et al : The Sydney multicenter study of Parkinson's disease : the inevitability of dementia at 20 years. Mov Disord 23 : 837-844, 2008.
PubMed
4) Emre M, et al : Clinical diagnostic criteria for dementia associated with Parkinson's disease. Mov Disord 22 : 1689-1707 ; quiz 1837, 2007.
 
5) Polymeropoulos MH, et al : Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276 : 2045-2047, 1997.
PubMed
6) Spillantini MG, et al : Alpha-synuclein in Lewy bodies. Nature 388 : 839-840, 1997.
PubMed
7) Braak H, et al : Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 24 : 197-211, 2003.
PubMed
8) Kordower JH, et al : Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat Med 14 : 504-506, 2008.
PubMed
9) Recasens A, et al : Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys. Ann Neurol 75 : 351-362, 2014.
 
10) Phani S, et al : Neurodegeneration and inflammation in Parkinson's disease. Parkinsonism Relat Disord 18 (Supple 1) : S207-209, 2012.
 
11) 日本神経学 (監), 「パーキンソン病診療ガイドライン」作成委員会 (編) : パーキンソン病診療ガイドライン 2018, 医学書院2018.
 
12) Satake W, et al : Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nat Genet 41 : 1303-1307, 2009.
PubMed
13) Postuma RB, et al : MDS clinical diagnostic criteria for Parkinson's disease. Mov Disord 30 : 1591-1601, 2015.
PubMed
14) Berg D, et al : MDS research criteria for prodromal Parkinson's disease. Mov Disord 30 : 1600-1611, 2015.
PubMed
15) 相原守夫 : 診療ガイドラインのためのGRADEシステム-第2版-, 凸メディア株式会社, 2015.
 
P.522 掲載の参考文献
1) Fisher RS, et al : Epileptic seizures and epilepsy : definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia 46 : 470-472, 2005.
PubMed
2) Fisher RS, et al : ILAE official report : a practical clinical definition of epilepsy. Epilepsia 55 : 475-482, 2014.
PubMed
3) Fisher RS, et al : Operational classification of seizure types by the International League Against Epilepsy : Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 58 : 522-530, 2017.
PubMed
4) Tsuji S, Akamatsu N : Treatment of epilepsy. Rinsho Shinkeigaku 48 : 550-555, 2008.
PubMed
5) 赤松直樹, 辻貞俊 : 痙攣. medicina 53 : 81-84, 2016.
 
6) Tanaka A, Akamatsu N : Clinical characteristics and treatment responses in new-onset epilepsy in the elderly. Seizure 22 : 772-775, 2013.
PubMed
P.528 掲載の参考文献
1) 脳卒中治療ガイドライン 2015 (日本脳卒中学会脳卒中ガイドライン委員会編), 協和企画, 2015.
 
2) 厚生労働省 : 平成18年 (2006年) 人口動態統計.
 
3) 加藤裕司, 棚橋紀夫 : 加齢医学の面からみた脳卒中. 脳卒中データバンク 2015 (小林祥泰編), p32-33, 中山書店, 2015,
 
4) Kannel WB, et al : Systolic blood pressure, arterial rigidity, and risk of stroke. The Framingham study. JAMA 245 : 1225-1229, 1981.
PubMed
5) MacMahon S, et al : Blood pressure, stroke, and coronary heart disease. Part 1, Prolonged differences in blood pressure : prospective observational studies corrected for the regression dilution bias. Lancet 335 : 765-774, 1990.
PubMed
6) Collins R, et al : Blood pressure, stroke, and coronary heart disease. Part 2, Short-term reductions in blood pressure : overview of randomised drug trials in their epidemiological context. Lancet 335 : 827-838, 1990.
PubMed
7) Staessen JA, et al : Risks of untreated and treated isolated systolic hypertension in the elderly : metaanalysis of outcome trials. Lancet 355 : 865-872, 2000.
PubMed
8) Kannel WB, McGee DL : Diabetes and cardiovascular disease. The Framingham study. JAMA 241 : 2035-2038, 1979.
PubMed
9) Emerging Risk Factors Collaboration ; Sarwar N, et al : Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease : a collaborative meta-analysis of 102 prospective studies. Lancet 375 : 2215-2222, 2010.
PubMed
10) Gaede P, et al : Effect of a multifactorial intervention on mortality in type 2 diabetes. N Engl J Med 358 : 580-591, 2008.
PubMed
11) Boysen G, et al : Stroke incidence and risk factors for stroke in Copenhagen, Denmark. Stroke 19 : 1345-1353, 1988.
 
12) Baigent C, et al : Efficacy and safety of cholesterol-lowering treatment : prospective meta-analysis of data from 90, 056 participants in 14 randomised trials of statins. Lancet 366 : 1267-1278, 2005.
PubMed
13) Wolf PA, et al : Atrial fibrillation as an independent risk factor for stroke : the Framingham Study. Stroke 22 : 983-988, 1991.
PubMed
14) Go AS, et al : Anticoagulation therapy for stroke prevention in atrial fibrillation : how well do randomized trials translate into clinical practice? JAMA 290 : 2685-2692, 2003.
PubMed
15) Connolly SJ, et al : Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 361 : 1139-1151, 2009.
PubMed
P.533 掲載の参考文献
1) Petty GW, et al : Ischemic stroke subtypes : a population-based study of functional outcome, survival, and recurrence. Stroke 31 : 1062-1068, 2000.
PubMed
2) Adams HP Jr, et al : Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 24 : 35-41, 1993.
 
3) Pantoni L : Cerebral small vessel disease : from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol 9 : 689-701, 2010.
PubMed
4) Grinberg LT, Thal DR : Vascular pathology in the aged human brain. Acta Neuropathol 119 : 277-290, 2010.
PubMed
5) Caplan LR : Intracranial branch atheromatous disease : a neglected, understudied, and underused concept. Neurology 39 : 1246-1250, 1989.
PubMed
6) Fisher CM : Lacunar strokes and infarcts : a review. Neurology 32 : 871-876, 1982.
PubMed
7) Arboix A, et al : Clinical study of 39 patients with atypical lacunar syndrome. J Neurol Neurosurg Psychiatry 77 : 381-384, 2006.
PubMed
8) Moreau F, et al : Cavitation after acute symptomatic lacunar stroke depends on time, location, and MRI sequence. Stroke 43 : 1837-1842, 2012.
PubMed
9) Shinohara Y, et al : Effect of the Ca antagonist nilvadipine on stroke occurrence or recurrence and extension of a symptomatic cerebral infarction in hypertensive patients with or without history of stroke (PICA Study). 1. Design and results at enrollment. Cerebrovasc Dis 24 : 202-209, 2007.
 
10) 日本脳卒中学会脳卒中ガイドライン委員会 (編) : 脳卒中治療ガイドライン2015, 協和企画, 2015.
 
11) Pantoni L, et al : Thrombolysis in acute stroke patients with cerebral small vessel disease. Cerebrovasc Dis 37 : 5-13, 2014.
PubMed
12) Wang Y, et al : Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med 369 : 11-19, 2013.
 
13) SPS3 Investigators, et al : Effects of clopidogrel added to aspirin in patients with recent lacunar stroke. N Engl J Med 367 : 817-825, 2012.
PubMed
14) Shinohara Y, et al : Cilostazol for prevention of secondary stroke (CSPS 2) : an aspirin-controlled, double-blind, randomised non-inferiority trial. Lancet Neurol 9 : 959-968, 2010.
PubMed
15) SPS3 Study Group, et al : Blood-pressure targets in patients with recent lacunar stroke : the SPS3 randomised trial. Lancet 382 : 507-515, 2013.
 
P.538 掲載の参考文献
1) 今泉俊雄, 稲村茂 : Microbleedsによる脳卒中再発予測 : 脳卒中タイプでの違い. 脳卒中 40 : 105-111, 2018.
Medical*Online
2) Wilson D, et al : Recurrent stroke risk and cerebral microbleed burden in ischemic stroke and TIA : A meta-analysis. Neurology 87 : 1501-1510, 2016.
 
3) Charidimou A, et al : Brain hemorrhage recurrence, small vessel disease type, and cerebral microbleeds : A meta-analysis. Neurology 89 : 820-829, 2017.
PubMed
4) Charidimou A, et al : Brain microbleeds, anticoagulation, and hemorrhage risk : Meta-analysis in stroke patients with AF. Neurology 89 : 2317-2326, 2017.
PubMed
5) Lovelock CE, et al : Antithrombotic drug use, cerebral microbleeds, and intracerebral hemorrhage : a systematic review of published and unpublished studies. Stroke 41 : 1222-1228, 2010.
PubMed
6) Miyatani F, et al : Relationship between Cnm-positive Streptococcus mutans and cerebral microbleeds in humans. Oral Dis 21 : 886-893, 2015.
PubMed
7) Roongpiboonsopit D, et al : Evolution of cerebral microbleeds after cranial irradiation in medulloblastoma patients. Neurology 88 : 789-796, 2017.
PubMed
8) Pasi M, et al : Mixed-location cerebral hemorrhage/microbleeds : Underlying microangiopathy and recurrence risk. Neurology 90 : e119-e126, 2018.
PubMed
9) Kim YJ, et al : Synergistic effects of longitudinal amyloid and vascular changes on lobar microbleeds. Neurology 87 : 1575-1582, 2016.
PubMed
10) Bokura H, et al : Microbleeds are associated with subsequent hemorrhagic and ischemic stroke in healthy elderly individuals. Stroke 42 : 1867-1871, 2011.
PubMed
11) van Etten ES, et al : Incidence of symptomatic hemorrhage in patients with lobar microbleeds. Stroke 45 : 2280-2285, 2014.
PubMed
12) Charidimou A, et al : Cerebral microbleeds and recurrent stroke risk : systematic review and metaanalysis of prospective ischemic stroke and transient ischemic attack cohorts. Stroke 44 : 995-1001, 2013.
PubMed
13) Evans A, et al : The spot sign is more common in the absence of multiple prior microbleeds. Stroke 41 : 2210-2217, 2010.
PubMed
14) Imaizumi T, et al : Hematoma size in deep intracerebral hemorrhage and its correlation with dot-like hemosiderin spots on gradient echo T2*-weighted MRI. J Neuroimaging 16 : 236-242, 2006.
PubMed
P.544 掲載の参考文献
1) Charidimou A, et al : Emerging concepts in sporadic cerebral amyloid angiopathy. Brain 140 : 1829-1850, 2017.
PubMed
2) Inoue Y, et al : Sushi repeat-containing protein 1 : a novel disease-associated molecule in cerebral amyloid angiopathy. Acta Neuropathol 134 : 605-617, 2017.
PubMed
3) Matsuo K, et al : Complement Activation in Capillary Cerebral Amyloid Angiopathy. Dement Geriatr Cogn Disord 44 : 343-353, 2017.
PubMed
4) Rosand J, et al : Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy. Ann Neurol 58 : 459-462, 2005.
PubMed
5) Matsuyama H, et al : Background and distribution of lobar microbleeds in cognitive dysfunction. Brain Behav 7 : e00856, 2017.
PubMed
6) Ii Y, et al : In vivo detection of cortical microinfarcts on ultrahigh-field MRL J Neuroimaging 23 : 28-32, 2013.
 
7) Martinez-Ramirez S, et al : Diagnostic value of lobar microbleeds in individuals without intracerebral hemorrhage. Alzheimers Dement 11 : 1480-1488, 2015.
PubMed
8) Greenberg SM, et al : Diagnosis of Cerebral Amyloid Angiopathy : Evolution of the Boston Criteria. Stroke 49 : 491-497, 2018.
PubMed
9) Charidimou A, et al : Total Magnetic Resonance Imaging Burden of Small Vessel Disease in Cerebral Amyloid Angiopathy : An Imaging-Pathologic Study of Concept Validation. JAMA Neurol 73 : 994-1001, 2016.
PubMed
10) Roongpiboonsopit D, et al : Cortical superficial siderosis predicts early recurrent lobar hemorrhage. Neurology 87 : 1863-1870, 2016.
PubMed
11) Reijmer YD, et al : Structural network alterations and neurological dysfunction in cerebral amyloid angiopathy. Brain 138 : 179-188, 2015.
PubMed
12) Xiong L, et al : Dementia incidence and predictors in cerebral amyloid angiopathy patients without intracerebral hemorrhage. J Cereb Blood Flow Metab 38 : 241-249, 2018.
PubMed
13) Auriel E, et al : Validation of Clinicoradiological Criteria for the Diagnosis of Cerebral Amyloid Angiopathy-Related Inflammation. JAMA Neurol 73 : 197-202, 2016.
PubMed
14) Maki T, et al : Phosphodiesterase III inhibitor promotes drainage of cerebrovascular p-amyloid. Ann Clin Transl Neurol 1 : 519-533, 2014.
 
15) Saito S, et al : Taxifolin inhibits amyloid-β oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy. Acta Neuropathol Commun 5 : 26, 2017.
 
P.550 掲載の参考文献
1) 久保田競 : 脳科学の進歩とニューロリハビリテーション. 理学療法 24 : 1523-1531, 2007.
 
2) 道免和久 : ニューロリハビリテーション概論. ニューロリハビリテーション (道免和久編), p1-4, 医学書院, 2015.
 
3) National Policy and Strategy for the Provision of Neuro-Rehabiritation Services in Ireland 2011-2015. Departmentof Health (IE), 2011.
 
4) Altschuler EL, et al : Rehabilitation of hemiparesis after stroke with a mirror. Lancet 353 : 2035-2036, 1999.
PubMed
5) Dickstein R, et al : Motor imagery for gait rehabilitation in post-stroke hemiparesis. Phys Ther 84 : 1167-1177, 2004.
PubMed
6) Tamir R, et al : Integration of motor imagery and physical practice in group treatment applied to subjects with Parkinson's disease. Neurorehabil Neural Repair 21 : 68-75, 2007.
PubMed
7) 川平和美, ほか : 片麻痺回復のための運動療法-促通反復療法「川平法」の理論と実際, 第3版, 医学書院, 2017.
 
8) 下堂薗恵 : 促通反復療法の治療成績と効果的な併用療法の開発. 臨床神経学 53 : 1267-1269, 2013.
 
9) 野間知一, ほか : 慢性期の脳卒中片麻痺上肢への促通反復療法の効果. 総合リハビリテーション 36 : 695-699, 2008.
 
10) Shimodozono M, et al : Benefits of a repetitive facilitative exercise program for the upper paretic extremity after subacute stroke : a randomized controlled trial. Neurorehabil Neural Repair 27 : 296-305, 2013.
PubMed
11) 高畑進一, ほか : パーキンソン病はこうすれば変わる! 日常生活の工夫とパーキンソンダンスで生活機能を改善 (高畑進一, 宮口英樹編), 三輪書店, p38-42, p102-113, 2012.
 
12) Hashimoto H, et al : Effects of dance on thotor functions, cognitive functions, and mental symptoms of Parkinson's disease : a quasi-randomized pilot trial. Complement Ther Med 23 : 210-219, 2015.
PubMed
13) 中島孝 : 難治性神経・筋疾患に対するコミュニケーション支援技術 : 透明文字盤, 口文字法から最新のサイバニックインターフェイスまで. 保健医療科学 66 (5) : p491-496, 2017.
 
14) 平田雅之 : ブレインマシンインターフェース (BMI). Clinical Neuroscience 34 : 144-148, 2016.
 
15) 小林貴代 : 脳の活動とこころをかさねて観るコミュニケーション支援の可能性について. 森ノ宮医療大学紀要 12 : 57-67, 2018.
 
P.555 掲載の参考文献
1) Pollard AJ, et al : Maintaining Protection against invasive bacteria with protein-polysaccharide conjugate vaccines. Nat Rev Immunol 9 : 213-220, 2009.
PubMed
2) Maruyama T, et al : Efficacy of 23-valent pneumococcal vaccine in preventing pneumonia and improving survival in nursing home residents : double blind, randomised and placebo controlled trial. BMJ 340 : c1004, 2010.
PubMed
3) Kawakami K, et al : Effectiveness of pneumococcal polysaccharide vaccine against pneumonia and cost analysis for the elderly who receive seasonal influenza vaccine in Japan. Vaccine 28 : 7063-7069, 2010.
PubMed
4) Suzuki M, et al : Serotype-specific effectiveness of 23-valent pneumococcal polysaccharide vaccine against pneumococcal pneumonia in adults aged 65 years or older : amulticentre, prospective, testnegative design study. Lancet Infect Dis 17 : 313-321, 2017.
PubMed
5) Bonten MJ, et al : Polysaccharide conjugate vaccine against pneumococcal pneumonia in adults. N Engl J Med 372 : 1114-1125, 2015.
PubMed
6) Kobayashi M, et al : Intervals Between PCV13 and PPSV23 Vaccines : Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep 64 : 944-947, 2015.
PubMed
7) Pilishvili T, et al : Sustained reductions in invasive pneumococcal disease in the era of conjugate vaccine. J Infect Dis 201 : 32-41, 2010.
PubMed
8) Waight PA, et al : Effect of the 13-valent pneumococcal conjugate vaccine on invasive pneumococcal disease in England and Wales 4 years after its introduction : an observational cohort study. Lancet Infect Dis 15 : 535-543, 2015.
PubMed
9) Ubukata K, et al : Serotype Changes and Drug Resistance in Invasive Pneumococcal Diseases in Adults after Vaccinations in Children, Japan, 2010-2013. Emerging Infect Dis 21 : 1956-1965, 2015.
PubMed
10) Fukusumi M, et al : Invasive pneumococcal disease among adults in Japan, April 2013 to March 2015 : disease characteristics and serotype distribution. BMC Infect Dis 17 : 2, 2017.
 
11) Ohshima N, et al : Sustained functional serotype-specific antibody after primary and secondary vaccinations with a pneumococcal polysaccharide vaccine in elderly patients with chronic lung disease. Vaccine 32 : 1181-1186, 2014.
PubMed
12) Kawakami K, et al : Revaccination with 23-valent pneumococcal polysaccharide vaccine in the Japanese elderly is well tolerated and elicits immune responses. Vaccine 34 : 3875-3881, 2016.
PubMed
13) JOINT COMMITTEE ON VACCINATION AND IMMUNISATION. Minute of the meeting on 3 February 2016. [https://app.box.com/s/iddfb4ppwkmtjusir2tc/1/2199012147/229171963867/1] (2018年7月閲覧)
 
14) Falkenhorst G, et al : Background paper to the updated pneumococcal vaccination recommendation for older adults in Germany. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 59 : 1623-1657, 2016.
 
15) Centers for Disease Control and Prevention (CDC) : Use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine for adults with immunocompromising conditions : recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep 61 : 816-819, 2012.
PubMed
P.560 掲載の参考文献
1) Lui KJ, Kendal AP : Impact of influenza epidemics on mortality in the United States from October 1972 to May 1985. Am J Public Health 77 : 712-716, 1987.
PubMed
2) 池松秀之, ほか : インフルエンザ診療マニュアル 2017-2018年シーズン版 (第12版), 日本臨床内科医会会誌 32 (臨時付録), 2017.
 
3) Cox NJ, Subbarao K : Influenza. Lancet 354 : 1277-1282, 1999.
PubMed
4) 河合直樹, ほか : 2002/2003年のインフルエンザ流行時における臨床症状の検討. 感染症学雑誌 78 : 681-689, 2004.
 
5) 池松秀之, ほか : 一般成人及び高齢者におけるインフルエンザ迅速診断キットの有用性についての検討. 感染症学雑誌 73 : 1153-1158, 1999.
 
6) 池松秀之 : インフルエンザ肺炎. 臨床と研究 77 : 2279-2282, 2000.
Medical*Online
7) 河合直樹 : インフルエンザヒトからヒトへの感染症-呼吸器感染症. 臨床と研究 81 : 1614-1918, 2004.
 
8) Gross PA, et al : Association of influenza immunization with reduction in mortality in an elderly population. A prospective study. Arch Intern Med 148 : 562-565, 1988.
 
9) Nichol KL, et al : The efficacy and cost effectiveness of vaccination against influenza among elderly persons living in the community. N Engl J Med 331 : 778-784, 1994.
PubMed
10) 池松秀之, ほか : 高齢者におけるインフルエンザワクチンの効果と安全性. 日本臨床 55 : 2751-2757, 1997.
Medical*Online
11) 池松秀之, 柏木征三郎 : 高齢者施設でのA香港型インフルエンザ流行時におけるアマンタジンの使用経験. 感染症学雑誌 74 : 476-480, 2000.
 
12) 渡辺彰, ほか : 高齢者等ハイリスク者に対する長時間作用型ノイラミニダーゼ阻害剤laninamivir octanoate hydrateの予防投与における安全性とインフルエンザ発症予防効果の検討. 感染症学雑誌 92 : 51-60, 2018.
 
P.565 掲載の参考文献
1) 厚生労働省 : 薬剤耐性 (AMR) について [http://www.mhlw.go.jp/stf/seisakunitsuite/bunya/0000120172.html] (2018年6月閲覧)
 
2) Yamamoto N, et al : Prevalence of, and risk factors for, carriage of carbapenem-resistant Enterobacteriaceae among hospitalized patients in Japan. J Hosp Infect 97 : 212-217, 2017.
PubMed
3) 日本呼吸器学会成人肺炎診療ガイドライン 2017作成委員会 : 成人肺炎診療ガイドライン 2017, 日本呼吸器学会, 2017.
 
4) 厚生労働省 : 「人生の最終段階における医療の決定プロセスに関するガイドライン」の改訂について [http://www.mhlw.go.jp/stf/houdou/0000197665.html] (2018年6月閲覧)
 
P.571 掲載の参考文献
1) Kohno A, Hara Y : Severe myocardial ischemia following hormone replacement in two cases of hypothyroidism with normal coronary arteriogram. Endocr J 48 : 565-572, 2001.
PubMed
2) Oe K, et al : Acute myocardial infarction following hormone replacement in hypothyroidism. Int Heart J 48 : 107-111, 2007.
PubMed
3) Jonklaas J, et al : Guidelines for the treatment of hypothyroidism : prepared by the american thyroid association task force on thyroid hormone replacement. Thyroid 24 : 1670-1751, 2014.
PubMed
4) Grebe SK, et al : Treatment of hypothyroidism with once weekly thyroxine. J Clin Endocrinol Metab 82 : 870-875, 1997.
PubMed
5) 武田京子, 平松園枝 : 健診における潜在性甲状腺機能低下症と潜在性甲状腺機能亢進症の出現頻度. ホルモンと臨床 56 : 667-671, 2008.
 
6) Razvi S, et al : The influence of age on the relationship between subclinical hypothyroidism and ischemic heart disease : a metaanalysis. J Clin Endocrinol Metab 93 : 2998-3007, 2008.
PubMed
7) 網野信行, ほか : Subclinical hypothyroidism潜在性甲状腺機能低下症 : 診断と治療の手引き. ホルモンと臨床 56 : 705-724, 2008.
 
8) Pearce SH, et al : 2013 ETA Guideline : Management of Subclinical Hypothyroidism. Eur Thyroid J 2 : 215-228, 2013.
PubMed
9) Ross DS, et al : 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis. Thyroid 26 : 1343-1421, 2016.
PubMed
10) Miyauchi A, et al : Insights into the Management of Papillary Microcarcinoma of the Thyroid. Thyroid 28 : 23-31, 2018.
PubMed
P.576 掲載の参考文献
1) Yanase T, et al : Diagnosis and treatment of adrenal insufficiency including adrenal crisis : a Japan Endocrine Society clinical practice guideline [Opinion]. Endocr J 63 : 765-784, 2016.
PubMed
2) 田邉真紀人, 柳瀬敏彦 : 副腎不全-クリーゼの危険も-Medical Practice 33 : 1745-1749, 2016.
Medical*Online
3) 岩間信太郎, 有馬寛 : 免疫チェックポイント阻害剤による内分泌副作用の臨床とそのメカニズム. 日本臨床免疫学会会誌 40 : 90-94, 2017.
Medical*Online
4) 柳瀬敏彦 : DHEA補充療法の現状と展望. 日本内科学会雑誌 94 : 2195-2199, 2005.
 
5) Mah PM, et al : Weight-related dosing, timing and monitoring hydrocortisone replacement therapy in patients with adrenal insufficiency. Clin Endocrinol (Oxf) 61 : 367-375, 2004.
PubMed
6) Jung C, Inder WJ : Management of adrenal insufficiency during the stress of medical illness and surgery. Med J Aust 188 : 409-413, 2008.
PubMed
7) Chen YC, et al : Adrenal insufficiency in the elderly : a nationwide study of hospitalizations in Taiwan. Tohoku J Exp Med 221 : 281-285, 2010.
PubMed
8) Rushworth RL, Torpy DJ : A descriptive study of adrenal crises in adults with adrenal insufficiency : increased risk with age and in those with bacterial infections. BMC Endocr Disord 14 : 79, 2014.
PubMed
9) Rahvar AH, et al : Increased cardiovascular risk in patients with adrenal insufficiency : A short review. Biomed Res Int. 2017 : 3691913, 2017. (doi : 10.1155/2017/3691913)
 
P.580 掲載の参考文献
1) Savard S, et al : Cardiovascular complications associated with primary aldosteronism : a controlled cross-sectional study. Hypertension 62 : 331-336, 2013.
PubMed
2) Mulatero P, et al : Long-term cardio-and cerebrovascular events in patients with primary aldosteronism. J Clin Endocrinol Metab 98 : 4826-4833, 2013.
PubMed
3) わが国の原発性アルドステロン症の診療に関するコンセンサスステートメント (日本内分泌学会, 日本内分泌外科学会編). 2016. [https://minds.jcqhc.or.jp/n/med/4/med0255/G0000916] (2018年7月閲覧)
 
4) Nakama C, et al : The influence of aging on the diagnosis of primary aldosteronism. Hypertens Res 37 : 1062-1067, 2014.
PubMed
5) Williams TA, et al : Outcomes after adrenalectomy for unilateral primary aldosteronism : an international consensus on outcome measures and analysis of remission rates in an international cohort. Lancet Diabetes Endocrinol 5 : 689-699, 2017.
 
6) Nanba K, et al : Age-Related Autonomous Aldosteronism. Circulation 136 : 347-355, 2017.
PubMed
P.585 掲載の参考文献
1) 大中佳三, 高柳涼一 : 日常診療に活かす老年病ガイドブック 5, 骨粗鬆症と骨折予防 (大内尉義, ほか編), p88-94, メジカルビュー社, 2005.
 
2) Pacifici R : Estrogen deficiency, T cells and bone loss. Cell Immunol 252 (1-2) : 68-80, 2008.
 
3) 大中佳三 : 副甲状腺疾患. 新老年学 第3版 (大内尉義, ほか編), p1050-1059, 東京大学出版会, 2010.
 
4) Hu MC, et al : Fibroblast growth factor 23 and Klotho : physiology and pathophysiology of an endocrine network of mineral metabolism. Annu Rev Physiol 75 : 503-533, 2013.
PubMed
5) Sun L, et al : FSH directly regulates bone mass. Cell 125 : 247-260, 2006.
PubMed
6) Nakamura T, et al : Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell 130 : 811-823, 2007.
PubMed
7) Maatta JA, et al : Inactivation of estrogen receptor α in bone-forming cells induces bone loss in female mice. FASEB J 27 : 478-488, 2013.
 
8) Kondoh S, et al : Estrogen receptorαin osteocytes regulates trabecular bone formation in female mice. Bone 60 : 68-77, 2014.
 
9) Kawano H, et al : Suppressive function of androgen receptor in bone resorption. Proc Natl Acad Sci USA 100 : 9416-9421, 2003.
PubMed
10) Smith EP, et al : Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med 331 : 1056-1061, 1994.
 
11) Morishima A, et al : Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J Clin Endocrinol Metab 80 : 3689-3698, 1995.
PubMed
12) Orimo H, et al : Hip fracture incidence in Japan : Estimates of new patients in 2012 and 25-year trends. Osteoporos Int 27 : 1777-1784, 2016.
PubMed
13) 厚生労働省難治性疾患克服研究事業ホルモン受容体機構異常に関する調査研究班, 日本骨代謝学会, 日本内分泌学会 : ビタミンD不足・欠乏の判定指針. 日本内分泌学会雑誌 93 (Suppl) : 1-10, 2017.
 
14) Bilezikian Jp, et al : Guidelines for the management of a symptomatic primary hyperparathyroidism : summary statement from the Fourth International Workshop. J Clin Endocrinol Metab 99 : 3561-3569, 2014.
 
15) 厚生労働省難治性疾患克服研究事業ホルモン受容体機構異常に関する調査研究班, 日本骨代謝学会, 日本内分泌学会 : くる病・骨軟化症の診断マニュアル. 日本内分泌学会雑誌 91 (Suppl) : 1-11, 2015.
 
16) Kuro-o M : Molecular Mechanisms Underlying Accelerated Aging by Defects in the FGF23-Klotho System. Int J Nephrol 2018 : 9679841, 2018.
PubMed
17) 骨粗鬆症の予防と治療ガイドライン作成委員会 (編) : 骨粗鬆症の予防と治療ガイドライン 2015年版, ライフサイエンス出版, 2015.
 
18) 顎骨壊死検討委員会 (編) : 骨吸収抑制薬関連顎骨壊死の病態と管理 : 顎骨壊死検討委員会ポジションペーパー 2016. [http://www.perio.jp/file/news/info_160926.pdf] (2018年6月閲覧)
 
19) Anastasilakis AD, et al : Clinical Features of 24 Patients With Rebound-Associated Vertebral Fractures After Denosumab Discontinuation : Systematic Review and Additional Cases. J Bone Miner Res 32 : 1291-1296, 2017.
 
20) Cosman F, et al : Romosozumab Treatment in Postmenopausal Women with Osteoporosis. N Engl J Med 375 : 1532-1543, 2016.
PubMed
P.591 掲載の参考文献
1) Shayne M, Lichtman MA : Hematology in older persons. In Williams Hematology, 7th edition (ed by Lichtman MA, et al), p111-121, McGraw-Hill, New York, 2006.
 
2) 白倉卓夫, ほか : 老年者'末梢血液像と赤血球産生能の変化. 日本老年医学会雑誌 15 : 151-157, 1978.
 
3) Ohta M : Management of Anemia in the Elderly. JMAJ 52 : 219-223, 2009.
 
4) Ganz T : Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 102 : 783-788, 2003.
 
5) Dallalio G, et al : Hepcidin inhibits in vitro erythroid colony formation at reduced erythropoietin concentrations. Blood 107 : 2702-2704, 2006.
PubMed
6) Theurl I, et al : Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia : diagnostic and therapeutic implications. Blood 113 : 5277-5286, 2009.
PubMed
7) Bohlius J, et al : Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer : a meta-analysis of randomised trials. Lancet 373 : 1532-1542, 2009.
 
8) Valent P, et al : Proposed minimal diagnostic criteria for myelodysplastic syndromes (MDS) and potential pre-MDS conditions. Oncotarget 8 : 73483-73500, 2017.
PubMed
9) 宮腰重三郎 : 特集 高齢者の血球 (数) 異常 (白血病・腫瘍性疾患を除く) 貧血・赤血球増加症. 日本老年医学会雑誌 51 : 510-516, 2014.
 
P.595 掲載の参考文献
1) O'Donnell MR, et al : Acute Myeloid Leukemia, Version 3. 2017, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 15 : 926-957, 2017.
PubMed
2) Lowenberg B, et al : High-dose daunorubicin in older patients with acute myeloid leukemia. N Engl J Med 361 : 1235-1248, 2009.
PubMed
3) Fenaux P, et al : Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes : a randomised, open-label, phase III study. Lancet Oncol 10 : 223-232, 2009.
PubMed
4) Castaigne S, et al : Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701) : a randomised, open-label, phase 3 study. Lancet 379 : 1508-1516, 2012.
PubMed
5) Hochhaus A, et al : Long-Term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia. N Engl J Med 376 : 917-927, 2017.
PubMed
6) Tauchi T, et al : Seven-year follow-up of patients receiving imatinib for the treatment of newly diagnosed chronic myelogenous leukemia by the TARGET system. Leuk Res 35 : 585-590, 2011.
PubMed
7) Etienne G, et al : Long-Term Follow-Up of the French Stop Imatinib (STIMI) Study in Patients With Chronic Myeloid Leukemia. J Clin Oncol 35 : 298-305, 2017.
 
8) Larson RA : Management of acute lymphoblastic leukemia in older patients. Semin Hematol 43 : 126-133, 2006.
PubMed
9) Snyder DS : Allogeneic stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia. Biol Blood Marrow Transplant 6 : 597-603, 2000.
PubMed
10) Yanada M, Naoe T : Imatinib combined chemotherapy for Philadelphia chromosome-positive acute lymphoblastic leukemia : major challenges in current practice. Leuk Lymphoma 47 : 1747-1753, 2006.
PubMed
11) Ravandi F, et al : First report of phase 2 study of dasatinib with hyper-CVAD for the frontline treatment of patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia. Blood 116 : 2070-2077, 2010.
PubMed
12) Foa R, et al : Dasatinib as first-line treatment for adult patients with Philadelphia chromosomepositive acute lymphoblastic leukemia. Blood 118 : 6521-6528, 2011.
PubMed
P.604 掲載の参考文献
1) 宮崎泰司, ほか : 骨髄異形成症候群診療の参照ガイド (平成28年度改訂版). 厚生労働省科学研究費補助金難治性疾患克服研究事業 特発性造血障害に関する調査研究班. 研究代表者荒井俊也 [http://zoketsushogaihan.com/file/guideline_H28/04.pdf] (2018年6月閲覧)
 
2) Hasserjian RP, et al : Myelodysplastic syndromes : overview. In : WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, revised 4th edition (ed by Swerdlow SH, et al), p98-106, IARC Press, Lyon, 2017.
 
3) 朝長万左男, 松田晃 (編) : 不応性貧血 (骨髄異形成症候群) の形態学的異形成に基づく診断確度区分と形態診断アトラス. [http://www.jslh.com/MDS.pdf]
 
4) Matsuda A, et al : Proposals for a grading system for diagnostic accuracy of the myelodysplastic syndromes. Clin Leuk 2 : 102-106, 2008.
 
5) Della Porta MG, et al : Minimal morphological criteria for defining bone marrow dysplasia : a basis for clinical implementation of WHO classification of myelodysplastic syndromes. Leukemia 29 : 66-75, 2015.
PubMed
6) Matsuda A, et al : Difference in clinical features between Japanese and German patients with refractory anemia in myelodysplastic syndromes. Blood 106 : 2633-2640, 2005.
PubMed
7) Bennett JM, et al : Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 51 : 189-199, 1982.
PubMed
8) Greenberg P, et al : International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood 89 : 2079-2088, 1997.
PubMed
9) Greenberg PL, et al : Revised international prognostic scoring system for myelodysplastic syndromes. Blood 120 : 2454-2465, 2012.
PubMed
10) NCCN, Clinical Practice Guidelines in Oncology. Myelodysplastic syndromes V. 2. 2018. [https://www.nccn.org/professionals/physician_gls/pdf/mds.pdf]
 
11) Hellstr6m-Lindberg E : Efficacy of erythropoietin in the myelodysplastic syndromes : a meta-analysis of 205 patients from 17 studies. Br J Haematol 89 : 67-71, 1995.
 
12) Fenaux P, et al : A randomized phase 3 study of lenalidomide versus placebo in RBC transfusiondependent patients with Low-/Intermediate-1-risk myelodysplastic syndromes with del5q. Blood 118 : 3765-3776, 2011.
PubMed
13) Passweg JR, et al : Immunosuppressive therapy for patients with myelodysplastic syndrome : a prospective randomized multicenter phase III trial comparing antithymocyte globulin plus cyclosporine with best supportive care-SAKK 33/99. J Clin Oncol 29 : 303-309, 2011.
PubMed
14) Cutler CS, et al : A decision analysis of allogeneic bone marrow transplantation for the myelodysplastic syndromes : delayed transplantation for low-risk myelodysplasia is associated with improved outcome. Blood 104 : 579-585, 2004.
PubMed
15) Fenaux P, et al : Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes : a randomised, open-label, phase III study. Lancet Oncol 10 : 223-232, 2009.
PubMed
P.608 掲載の参考文献
1) Coiffier B, et al : Long-term outcome of patients in the LNH-98.5 trial, the first randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients : astudy by the Groupe d'Etudes des Lymphomes de l'Adulte. Blood 116 : 2040-2045, 2010.
 
2) Pfreundschuh M, et al : CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large-B-cell lymphoma : a randomised controlled trial by the MabThera International Trial (MInT) Group. Lancet Oncol 7 (5) : 379-391, 2006.
PubMed
3) Persky DO, et al : Phase II study of rituximab plus three cycles of CHOP and involved-field radiotherapy for patients with limited-stage aggressive B-cell lymphoma : Southwest Oncology Group study 0014. J Clin Oncol 26 : 2258-2263, 2008.
 
4) Delarue R, et al : Dose-dense rituximab-CHOP compared with standard rituximab-CHOP in elderly patients with diffuse large B-cell lymphoma (the LNH03-6B study) : a randomised phase 3 trial. Lancet Oncol 14 : 525-533, 2013.
PubMed
5) Peyrade F, et al : Attenuated immunochemotherapy regimen (R-miniCHOP) in elderly patients older than 80 years with diffuse large B-cell lymphoma : a multicentre, single-arm, phase 2 trial. Lancet Oncol 12 : 460-468, 2011.
PubMed
6) Coleman M, et al : Prednisone, etoposide, procarbazine, and cyclophosphamide (PEP-C) oral combination chemotherapy regimen for recurring/refractory lymphoma : low-dose metronomic, multidrug therapy, Cancer 112 : 2228-2232, 2008.
PubMed
7) Salles G, et al : Rituximab maintenance for 2 years in patients with high tumour burden follicular lymphoma responding to rituximab plus chemotherapy (PRIMA) : a phase 3, randomised controlled trial. Lancet 377 : 42-51, 2011.
 
8) Oyama T, et al : Senile EBV+ B-cell lymphoproliferative disorders : a clinicopathologic study of 22 patients. Am J Surg Pathol 27 : 16-26, 2003.
PubMed
9) Oyama T, et al : Age-related EBV-associated B-cell lymphoproliferative disorders constitute a distinct clinicopathologic group : astudy of 96 patients. Clin Cancer Res 13 : 5124-5132, 2007.
 
10) Nicolae A, et al : EBV-positive large B-cell lymphomas in young patients : a nodal lymphoma with evidence for a tolerogenic immune environment. Blood 126 : 863-872, 2015.
 
11) Doglioni C, et al : High incidence of primary gastric lymphoma in northeastern Italy. Lancet 339 : 834-835, 1992.
PubMed
12) Neelapu SS, et al : Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma. N Engl J Med 377 : 2531-2544, 2017.
 

XII 高齢者の手術

P.617 掲載の参考文献
1) Fried LP, et al : Frailty in older adults : evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56 : M146-156, 2001.
PubMed
2) Chen LK, et al : Sarcopenia in Asia : consensus report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc 15 : 95-101, 2014.
 
3) Chen CC, et al : Pre-surgical Geriatric Syndromes, Frailty, and Risks for Postoperative Delirium in Older Patients Undergoing Gastrointestinal Surgery : Prevalence and Red Flags. J Gastrointest Surg 19 : 927-934, 2015.
 
4) Hamaker ME, et al : Frailty screening methods for predicting outcome of a comprehensive geriatric assessment in elderly patients with cancer : a systematic review. Lancet Oncol 13 : e437-444, 2012.
 
5) Feng MA, et al : Geriatric assessment in surgical oncology : a systematic review. J Surg Res 193 : 265-272, 2015.
PubMed
6) Maekawa Y, et al : Comprehensive Geriatric Assessment is a useful predictive tool for postoperative delirium after gastrointestinal surgery in old-old adults. Geriatr Gerontol Int 16 : 1036-1042, 2016.
PubMed
7) Yamamoto M, et al : Risk Evaluation of Postoperative Delirium Using Comprehensive Geriatric Assessment in Elderly Patients with Esophageal Cancer. World J Surg 40 : 2705-2712, 2016.
PubMed
8) 山崎誠 : 外科疾患とフレイル. フレイルハンドブックポケット版 (荒井秀典編), p82-83, ライフ・サイエンス, 2016.
 
9) Nishizawa Y, et al : Clinical benefits of single-incision laparoscopic surgery for postoperative delirium in elderly colon cancer patients. Surg Endosc 32 : 1434-1440, 2018.
PubMed
10) Dasgupta M, et al : Frailty is associated with postoperative complications in older adults with medical problems. Arch Gerontol Geriatr 48 : 78-83, 2009.
PubMed
11) Makary MA, et al : Frailty as a predictor of surgical outcomes in older patients. J Am Coll Surg 210 : 901-908, 2010.
PubMed
12) Levolger S, et al : Systematic review of sarcopenia in patients operated on for gastrointestinal and hepatopancreatobiliary malignancies. Br J Surg 102 : 1448-1458, 2015.
PubMed
13) Kaido T, et al : Impact of sarcopenia on survival in patients undergoing living donor liver transplantation. Am J Transplant 13 : 1549-1556, 2013.
PubMed
14) Huang DD, et al : Sarcopenia predicts 1-year mortality in elderly patients undergoing curative gastrectomy for gastric cancer : a prospective study. J Cancer Res Clin Oncol 142 : 2347-2356, 2016.
PubMed
15) Makiura D, et al : Preoperative sarcopenia is a predictor of postoperative pulmonary complications in esophageal cancer following esophagectomy : A retrospective cohort study. J Geriatr Oncol 7 : 430-436, 2016.
PubMed
P.623 掲載の参考文献
1) Fearon KC, et al : Enhanced recovery after surgery : a consensus review of clinical care for patients undergoing colonic resection. Clin Nutr 24 : 466-477, 2005.
PubMed
2) Lassen K, et al : Consensus review of optimal perioperative care in colorectal surgery : Enhanced Recovery After Surgery (ERAS) Group recommendations. Arch Surg 144 : 961-969, 2009.
PubMed
3) Rennie MJ, Wilkes EA : Maintenance of the muscloskeletal mass by control of protein turnover : the concept of anabolic resistance and its relevance to the transplant recipient. Ann Transplant 10 (4) : 31-34, 2005.
 
4) Lutz CT, Quinn LS : Sarcopenia, obesity, and natural killer cell immune senescence in aging : altered cytokine levels as a common mechanism. Aging (Albany NY) 4 : 535-546, 2012.
PubMed
5) Mullen JT, et al : Impact of body mass index on perioperative outcomes in patients undergoing major intra-abdominal cancer surgery. Ann Surg Oncol 15 : 2164-2172, 2008.
PubMed
6) NICE-SUGAR Study Investigators, et al : Intensive versus conventional glucose control in critically ill patients. N Engl J Med 360 : 1283-1297, 2009.
 
7) Banno M, et al : Wheelchair half-marathon race increases natural killer cell activity in persons with cervical spinal cord injury. Spinal Cord 50 : 533-537, 2012.
PubMed
8) Bergan EH, et al : Impact of improvement in preoperative oral health on nosocomial pneumonia in a group of cardiac surgery patients : asingle arm prospective intervention study. Intensive Care Med 40 : 23-31, 2014.
 
9) Dardevet D, et al : Muscle wasting and resistance of muscle anabolism : the "anabolic threshold concept" for adapted nutritional strategies during sarcopenia. Scientific World Jounal 2012 : 269531, 2012.
 
10) Dhatariya K, et al : NHS Diabetes guideline for the perioperative management of the adult patient with diabetes. Diabet Med 29 : 420-433, 2012.
PubMed
11) NICE-SUGAR Study Investigators ; Finfer S, et al : Intensive versus conventional glucose control in critically ill patients. N Engl J Med 360 : 1283-1297, 2009.
 
12) Kurita N, et al : Risk Model for Distal Gastrectomy When Treating Gastric Cancer on the Basis of Data From 33,917 Japanese Patients Collected Using a Nationwide Web-based Data Entry System. Ann Surg 262 : 295-303, 2015.
PubMed
13) Drews T, et al : Postoperative delirium is an independent risk factor for posttraumatic stress disorder in the elderly patient : a prospective observational study. Eur J Anaesthesiol 32 : 147-151, 2015.
 
14) Pasin L, et al : Dexmedetomidine reduces the risk of delirium, agitation and confusion in critically Ill patients : a meta-analysis of randomized controlled trials. J Cardiothorac Vasc Anesth 28 : 1459-1466, 2014.
PubMed
15) Mangram AJ, et al : Guideline for Prevention of Surgical Site Infection, 1999. Centers for Disease Control and Prevention (CDC) Hospital Infection Control Practices Advisory Committee. Am J Infect Control 27 (2) : 97-132 ; quiz 133-134 ; discussion 96, 1999.
 
P.628 掲載の参考文献
1) Griffiths R, et al : Peri-operative care of the elderly 2014 : Association of Anaesthetists of Great Britain and Ireland. Anaesthesia 69 (Suppl 1) : 81-98, 2014.
 
2) Chow WB, et al : Optimal preoperative assessment of the geriatric surgical patient : a best practices guideline from the American College of Surgeons National Surgical Quality Improvement Program and the American Geriatrics Society, J Am Coll Surg 215 : 453-466, 2012.
 
3) Hosking MP, et al : Outcomes of surgery in patients 90 years of age and older. JAMA 261 : 1909-1915, 1989.
PubMed
4) ASA Physical Status Classification System. Last approved by the ASA house of Delegates on October 15, 2014. [https://www.asahq.org/resources/clinical-information/asa-physical-statusclassification-system] (2018年7月閲覧)
 
5) Makary MA, et al : Frailty as a predictor of surgical outcomes in older patients. J Am Coll Surg 210 : 901-908, 2010.
PubMed
6) Rundshagen I : Postoperative cognitive dysfunction. Dtsch Arztebl Int 111 : 119-125, 2014.
PubMed
7) Chung F, Assmann N : Car accidents after ambulatory surgery in patients without an escort. Anesth Analg 106 : 817-820, 2018.
 
8) Dokkedal U, et al : Cognitive Functioning after Surgery in Middle-aged and Elderly Danish Twins. Anesthesiology 124 : 312-321, 2016.
PubMed
9) Steinmetz J, et al : Long-term consequences of postoperative cognitive dysfunction. Anesthesiology 110 : 548-555, 2009.
PubMed
10) Fleisher LA, et al : ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery : a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery) : developed in collaboration with the American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, and Society for Vascular Surgery. Circulation 116 : e418-499, 2007.
 
11) Lee TH, et al : Derivation and prospective validation of a simple index for prediction of cardiac risk of major noncardiac surgery. Circulation 100 : 1043-1049, 1999.
PubMed
12) Smetana GW, et al : Preoperative pulmonary risk stratification for noncardiothoracic surgery : systematic review for the American College of Physicians. Ann Intern Med 144 : 581-595, 2006.
PubMed
13) Canet J, et al : Prediction of postoperative pulmonary complications in a population-based surgical cohort. Anesthesiology 113 : 1338-1350, 2010.
 
14) Qaseem A, et al : Risk assessment for and strategies to reduce perioperative pulmonary complications for patients undergoing noncardiothoracic surgery : aguideline from the American College of Physicians. Ann Intern Med 144 : 575-580, 2006.
 

XIII 高齢者の救急医療

P.636 掲載の参考文献
1) 国立社会保障・人口問題研究所 : 日本の将来推計人口 (平成29年推計). [http://www.ipss.go.jp] (2018年5月閲覧)
 
2) 総務省消防庁 : 平成29年版救急・救助の現況. [http://www.fdma.go.jp/neuter/topics/houdou/h29/12/291219_houdou_2.pdf] (2018年5月閲覧)
 
3) 松田晋哉 : 超高齢社会の進展と予想される傷病構造, 医療提供体制の変化. 日本医師会雑誌 144 : 2225-2229, 2016.
 
4) 太田凡 : ER型救急における高齢者救急の現状. 日本老年医学会雑誌 48 : 317-321, 2011.
 
5) 武井泉 : 参考「救急医療情報キット」について. 日本老年医学会雑誌 48 : 332-335, 2011.
 
6) 嶋津岳士 : 救急医療の現状と課題. 生産と技術 63 : 113-118, 2011.
 
P.641 掲載の参考文献
1) 井上聖啓, ほか : 昏睡と意識障害. メディカル・サイエンス・インターナショナル, 2001.
 
2) 箕輪良行 : 意識障害. 救急診療指針 第4版 (日本救急医学会専門医認定委員会編), p272-275, へるす出版, 2011.
 
3) 杉野達也 : 意識障害. 日本臨牀 71 : 1004-1008, 2013.
Medical*Online
4) 救急救命士の心肺機能停止前の重度傷病者に対する静脈路確保及び輸液, 血糖測定並びに低血糖発作症例へのブドウ糖溶液の投与の実施等について. 厚生労働省医政局長通知, 2014.
 
P.645 掲載の参考文献
1) Proposal for revised clinical and electroencephalographic classification of epileptic seizures. From the Commission on Classification and Terminology of the International League Against Epilepsy. Epilepsia 22 : 489-501, 1981.
PubMed
2) Tanaka A, et al : Clinical characteristics and treatment responses in new-onset epilepsy in the elderly. Seizure 22 : 772-775, 2013.
PubMed
3) Guidelines for epidemiologic studies on epilepsy. Cornmission on Epidemiology and Prognosis, International League Against Epilepsy. Epilepsia 34 : 592-596, 1993.
PubMed
4) Thussu A, et al : Acute symptomatic seizures due to single CT lesions : how long to treat with antiepileptic drugs? Neurol India 50 : 141-144, 2002.
 
5) Narayanan JT, et al : New-onset acute symptomatic seizure in a neurological intensive care unit. Neurol India 55 : 136-140, 2007.
 
6) 日本老年医学会 (編) : 老年医学テキスト改訂第3版, p78-80, メジカルビュー社, 2008.
 
7) Vignatelli L, et al : Incidence and short-term prognosis of status epilepticus in adults in Bologna, Italy. Epilepsia 44 : 964-968, 2003.
PubMed
8) Mahowald MK, et al : REM sleep behavior disorder. In : Principles and Practice of Sleep Medicine, 2nd ed (ed by Kryger MH, et al), p574-588, W. B. Saunders, Philadelphia, 1994.
 
9) 内山真, ほか : 睡眠中の行動異常 高齢者および脳器質性疾患患者にみられたREM睡眠中のねぼけ行動について. 臨床脳波 (0485-1447) 34 : 5-13, 1992.
 
10) McCarter SJ, et al : Diagnostic thresholds for quantitative REM sleep phasic burst duration, phasic and tonic muscle activity, and REM atonia index in REM sleep behavior disorder with and without comorbid obstructive sleep apnea. Sleep 37 : 1649-1662, 2014.
PubMed
11) McKeith IG, et al : Diagnosis and management of dementia with Lewy bodies : Fourth consensus report of the DLB Consortium. Neurology 89 : 88-100, 2017.
PubMed
12) Fick DM, et al : Delirium superimposed on dementia : a systematic review. J Am Geriatr Soc 50 : 1723-1732, 2002.
PubMed
13) Mendez M, et al : Seizures in elderly patients with dementia : epidemiology and management. Drugs Aging 20 : 791-803, 2003.
PubMed
P.653 掲載の参考文献
1) 堀進悟, ほか : 入浴関連事故の実態把握及び予防対策に関する研究 : 厚生労働科学研究費補助金循環器疾患・糖尿病等生活習慣病対策総合研究事業, 平成25年度総括・分担研究報告書, 2014.
 
2) Suzuki M, et al : Sudden Death Phenomenon While Bathing in Japan-Mortality Data. Circ J 81 : 1144-1149, 2017.
PubMed
3) Kiyohara K, et al : Characteristics and Outcomes of Bath-Related Out-of-Hospital Cardiac Arrest in Japan. Circ J 80 : 1564-1570, 2016.
PubMed
4) Suzuki M, et al : Relationship between Bath-related Deaths and Low Air Temperature. Intern Med 56 : 3173-3177, 2017.
PubMed
5) Yang K, et al : Bath-related Deaths in Korea between 2008-2015. J Korean Med Sci 33 : e108, 2018.
PubMed
6) Okuda T, et al : Bathtub drowning : An ll-year retrospective study in the state of Maryland. Forensic Sci Int 253 : 64-70, 2015.
 
7) Lin CY, et al : Unintentional drowning mortality, by age and body of water : an analysis of 60 countries. Inj Prev 21 : e43-50, 2015.
PubMed
8) 日本救急医学会 (編) : 熱中症診療ガイドライン 2015, 2015.
 
9) Inamasu J, et al : Clinical Characteristics of Stroke Occurring while Bathing. J Stroke Cerebrovasc Dis 26 : 1462-1466, 2017.
PubMed
10) Ender PT, Dolan MJ : Pneumonia associated with near-drowning. Clin Infect Dis 25 : 896-907, 1997.
PubMed
11) Tadie JM, et al : Drowning associated pneumonia : a descriptive cohort. Resuscitation 83 : 399-401, 2012.
PubMed
12) 日本蘇生協議会 (監) : JRC蘇生ガイドライン 2015, 医学書院, 2015.
 
13) 入浴関連事故研完班 : 気をつけて! 冬のお風呂の死亡事故. [http://www1.citymatsue.shimane.jp/anzen/shoubou/kyukyu-jyouhou/oukyuteate.data/ofurosiboujiko.pdf] (2018年7月閲覧)
 
14) 消費者庁 : 冬場に多発する高齢者の入浴中の事故にご注意ください! [http://www.caa.go.jp/policies/policy/consumer_safety/release/pdf/160120kouhyou_2.pdf] (2018年7月閲覧)
 
P.662 掲載の参考文献
1) 中井誠一 : 熱中症の疫学 (変遷). 熱中症～日本を襲う熱波の恐怖～改訂第2版 (日本救急医学会監修), p12-18, へるす出版, 2017.
 
2) 三宅康史, ほか : レセプトデータを用いた最近5年の熱中症患者の推移 (2010～2014年). 日本医師会雑誌 144 : 527-532, 2015.
 
3) 三宅康史, ほか : 2020年オリンピック・パラリンピック東京大会に向けた外国人・障害者等に対する熱中症対策に関する研究. 平成28年度厚生労働行政推進調査事業費補助金研究報告書.
 
4) 三宅康史 : 熱中症の病態生理-温調節から多臓器不全, DICまで-. 日本医師会雑誌 141 : 269-273, 2012.
 
5) 三宅康史 : 熱中症-医学的見地から-. 熱中症の現状と予防 (澤田晋一編著), p20-40, 杏林書院, 2015.
 
6) 日本救急医学会熱中症に関する委員会 : 熱中症の実態調査-日本救急医学会Heatstroke STUDY2012最終報告-. 日本救急医学会雑誌 25 : 846-862, 2014.
 
7) 日本救急医学会熱中症に関する委員会 : 熱中症診療ガイドライン 2015. (日本救急医学会編), 2015. [http://www.mhlw.go.jp/file/06-Seisakujouhou-10800000-Iseikyoku/heatstroke2015.pdf]
 
8) 環境省 : 熱中症環境保健マニュアル 2018. [http://www.wbgt.env.go.jp/heatillness_manual.php]
 
9) 三宅康史 : 体温の指標・基準 (特集 今日から使える「指標」と「基準」). 救急医学 42 : 181-188, 2018.
 
10) 三宅康史 : 我が国における高齢者熱中症の実態-Heatstroke STUDY 2010からの分析-. 日本臨牀 71 : 1065-1073, 2013.
Medical*Online
P.667 掲載の参考文献
1) 和田貴子 : 寒冷による疾患. 内科学, p2358-2360, 朝倉書店, 2013.
 

XIV 高齢者のリハビリテーション

P.675 掲載の参考文献
1) 飯島節 : 高齢者のリハビリテーション. 老年学テキスト (飯島節, 鳥羽研二編), p215-224, 南江堂, 2006.
 
2) Schopfer DW, Forman DE : Cardiac Rehabilitation in Older Adults. Can J Cardiol 32 : 1088-1096, 2016.
PubMed
3) Scott DJ, Quinn TJ : Principles of rehabilitation of older people. Medicine 45 : 1-5, 2017.
 
4) Kabboord AD, et al : Assessment of comorbidity burden and its association with functional rehabilitation outcome after stroke or hip fracture : A systematic review and meta-analysis. J Am Med Dir Assoc 17 : 1066. e13-1066. e21, 2016.
PubMed
5) Shahab S, et al : Depression Predicts Functional Outcome in Geriatric Inpatient Rehabilitation. Arch Phys Med Rehabil 98 : 500-507, 2017.
PubMed
P.679 掲載の参考文献
1) [http://www.japanpt.or.jp/about/data/statistics/] (2018年7月閲覧)
 
2) [http://www.mhlw.go.jp/toukei/list/26-19.html] (2018年7月閲覧)
 
3) 荒井秀典 : フレイルの意義. 日老医誌 51 : 497-501, 2014.
 
4) Puts MTE, et al : Interventions to prevent or reduce the level of frailty in community-dwelling older adults : a scoping review of the literature and international policies. Age Ageing 46 : 383-392, 2017.
 
5) de Labra C, et al : Effects of physical exercise interventions in frail older adults : a systematic review of randomized controlled trials. BMC Geriatr 15 : 154, 2015.
PubMed
6) Lozano-Montoya I, et al : Nonpharmacological interventions to treat physical frailty and sarcopenia in older patients : a systematic overview-the SENATOR Project ONTOP Series. Clin Interv Aging 12 : 721-740, 2017.
PubMed
7) Dent E, et al : The Asia-Pacific Clinical Practice Guidelines for the Management of Frailty. J Am Med Dir Assoc 18 : 564-575, 2017.
 
8) Marzetti E, et al ; SPRINTT Consortium : Physical activity and exercise as countermeasures to physical frailty and sarcopenia. Aging Clin Exp Res 29 : 35-42, 2017.
PubMed
P.683 掲載の参考文献
1) 山田孝 : 老人性痴呆疾患のリハビリテーションに関する研究. 平成6～7年度科学研究費補助金 (一般研究 C) 研究成果報告書, 1996.
 
2) 山田孝, 竹原敦 : 日本版ミラー幼児発達スクリーニング検査項目を用いた単一システムデザインによる老年痴呆患者に対する感覚統合的アプローチの効果. 作業療法 15 : 322-335, 1996.
 
3) 長谷由美子, 山田孝 : 人間作業モデルスクリーニングツールの活用により認知症の行動障害の軽減に至った事例. 作業行動研究 14 : 274-282, 2011.
 
4) 色部千春, ほか : 通所リハビリテーションを利用する認知症高齢者に対する人間作業モデルスクリーニングツールを用いた作業療法の効果. 作業行動研究 15 : 20-28, 2011.
Medical*Online
5) 井口知也, ほか : 認知症高齢者の絵カード評価法を用いた2事例の報告～認知症高齢者に対するクライアント中心の考え方と作業に焦点を当てた作業療法実践を目指して. 作業行動研究 17 : 75-87, 2011.
 
6) 山田孝, ほか : 認知症高齢者に対するプログラム計画のための文献レビュー. 作業行動研究 21 : 8-19, 2017.
Medical*Online
7) 山田孝, ほか : 認知症高齢者に対するプログラム開発のための作業療法士に対するニーズ評価. 作業行動研究 21 : 85-92, 2017.
Medical*Online
8) 山田孝, ほか : 認知症で作業を実施した群と作業を実施しなかった群のランダム化比較 : 予備的研究. 第25回日本作業行動学会学術集会 (金沢), 演題 5. 作業行動研究 19 : 73, 2015.
 
9) 山田孝, ほか : 認知症高齢者に作業を実施した群と作業を実施しなかった群の比較～コホート研究～. 作業行動研究 22, 印刷中, 2018.
 
10) 山田孝, ほか : 認知症者に対する作業中心の実験群と機能訓練中心の統制群のランダム化比較 : 予備的研究. 第27回日本作業行動学会学術集会 (浜松), 演題 34. 作業行動研究 21 (Suppl) : 45-46, 2017.
 
P.687 掲載の参考文献
1) 日本言語聴覚士協会 : 会員動向. [https://www.jaslht.or.jp/trend.html] (2018年6月閲覧)
 
2) 厚労省 : 医師・看護職員・理学療法士・作業療法士の従事者数について. [http://www.mhlw.go.jp/file/05-Shingikai-10801000-Iseikyoku-Soumuka/0000106658.pdf] (2018年6月閲覧)
 
3) 日本脳卒中学会・脳卒中ガイドライン委員会 (編) : 脳卒中治療ガイドライン 2015, 追補2017対応, 協和企画, 2017.
 
4) Brady MC, et al : Speech and language therapy for language problems after a stroke, 2016. [http://www.cochrane.org/CD00O425/STROKE_speech-and-language-therapy-language-problems-after-stroke] (2018年6月閲覧)
 
5) Mitchell C, et al : Interventions for speech problems (dysarthria) after stroke or other non-progressive brain injury, 2017. [http://www.cochrane.org/CD002088/STROKE_interventions-speech-problems-dysarthria-after-stroke-or-other-non-progressive-brain-injury] (2018年6月閲覧)
 
6) Palmer R, et al : Computer therapy compared with usual care for people with long-standing aphasia poststroke : a pilot randomized controlled trial. Stroke 43 : 1904-1911, 2012.
PubMed
7) ロボキュア, 臨床試験でロボットによる失語症向け言語リハビリの有効性を確認～人とロボットの協働による新しいリハビリの形～, ロボキュア, 2017. [http://robocure.jp/PR1707.pdf] (2018年6月閲覧)
 
8) Elsner B, et al : Direct electrical current to the brain for language impairment after stroke, 2015. [http://www.cochrane.org/CD009760/STROKE_direct-electrical-current-to-the-brain-for-language-impairment-after-stroke_] (2018年6月閲覧)
 
9) Khedr EM, et al : Dual-hemisphere repetitive transcranial magnetic stimulation for rehabilitation of poststroke aphasia : a randomized, double-blind clinical trial. Neurorehabil Neural Repair 28 : 740-750, 2014.
PubMed
10) Kakuda W, et al : Therapeutic application of 6-Hz-primed low-frequency rTMS combined with intensive speech therapy for post-stroke aphasia. Brain Inj 25 : 1242-1248, 2011.
PubMed
11) 日本呼吸器学会医療・介護関連肺炎 (NHCAP) 診療ガイドライン作成委員会 (編) : 医療・介護関連肺炎 (NHCAP) 診療ガイドライン, メディカルレビュー社, 2011. 修正2015.
 
12) Momosaki R, et al : Effect of dysphagia rehabilitation on oral intake in elderly patients with aspiration pneumonia. Geriatr Gerontol Int 15 : 694-699, 2015.
PubMed
13) Maeda K, et al : Tentative nil per os leads to poor outcomes in older adults with aspiration pneumonia. Clin Nutr 35 : 1147-1152, 2016.
PubMed
14) 日本摂食嚥下リハビリテーション学会 : 嚥下調整食学会分類 2013. [https://www.jsdr.or.jp/doc/classification2013.html] (2018年6月閲覧)
 
P.692 掲載の参考文献
1) Faucounau V, et al : Caregivers' requirements for in-home robotic agent for supporting communityliving elderly subjects with cognitive impairment. Technol Health Care 17 : 33-40, 2009.
PubMed
2) Wu YH, et al : The Attitudes and Perceptions of Older Adults With Mild Cognitive Impairment Toward an Assistive Robot. J Appl Gerontol 35 : 3-17, 2016.
PubMed
3) Pearce AJ, et al : Robotics to enable older adults to remain living at home. J Aging Res 2012 : 538169, 2012.
 
4) Svetina M : The reaction times of drivers aged 20 to 80 during a divided attention driving. Traffic Inj Prev 17 : 810-814, 2016.
PubMed
5) Frontera WR : Physiologic Changes of the Musculoskeletal System with Aging : A Brief Review. Phys Med Rehabil Clin N Am 28 : 705-711, 2017.
PubMed
6) Vellas BJ, et al : Fear of falling and restriction of mobility in elderly fallers. Age Ageing 26 : 189-193, 1997.
PubMed
7) Fletcher PC, Hirdes Jp : Restriction in activity associated with fear of falling among communitybased seniors using home care services. Age Ageing 33 : 273-279, 2004.
PubMed
8) Kempen GI, et al : Socio-demographic, health-related and psychosocial correlates of fear of falling and avoidance of activity in community-living older persons who avoid activity due to fear of falling. BMC Public Health 9 : 170, 2009.
PubMed
9) Tomita Y, et al : Association of Physical Performance and Pain With Fear of Falling Among Community-Dwelling Japanese Women Aged 65 Years and Older. Medicine (Baltimore) 94 : e1449, 2015.
PubMed
10) Delbaere K, et al : Fear-related avoidance of activities, falls and physical frailty. A prospective community-based cohort study. Age Ageing 33 : 368-373, 2004.
PubMed
11) Ozaki K, et al : Preliminary trial of postural strategy training using a personal transport assistance robot for patients with central nervous system disorder. Arch Phys Med Rehabil 94 : 59-66, 2013.
PubMed
12) Ozaki K, et al : Training with a balance exercise assist robot is more effective than conventional training for frail older adults. Geriatr Gerontol Int 17 : 1982-1990, 2017.
PubMed
13) Teranishi T, et al : An analysis of falls occurring in a convalescence rehabilitation ward-a decision tree classification of fall cases for the management of basic movements-JPn J Compr Rehabil Sci 4, 7-13, 2013.
 
14) Nakagawa S, et al : Tandem Stance Avoidance Using Adaptive and Asymmetric Admittance Control for Fall Prevention. IEEE Trans Neural Syst Rehabil Eng 24 : 542-550, 2016.
PubMed
15) Jeka JJ : Light touch contact as a balance aid. Phys Ther 77 : 476-487, 1997.
PubMed
P.696 掲載の参考文献
1) 総務省 : 統計からみた我が国の高齢者 (65歳以上). 統計トピックス No. 103 : 2-3, 総務省, 2017.
 
2) 厚生労働省 : 介護人材確保地域戦略会議 (第4回) (H28. 2. 1), 資料2, [http://www.mhlw.go.jp/file/05-Shingikai-12201000-Shakaiengokyokushougaihokenfukushibu-Kikakuka/document2.pdf] 厚生労働省, 2016.
 
3) 上田喜敏 : セーフティケアの介護・看護, p9-16, ヒューマン・ヘルスケア・システム, 2016.
 
4) 石川文武, ほか : Ergonomics-Manual handling-Part 1 : Lifting and carrying (人間工学-手作業-第1部 : 持ち上げ作業), 国際規格ISO 11228-1, 2003.
 
5) 厚生労働省 : 第145回社会保障審議会介護給付費分科会資料 2 介護人材確保対策 2017. [http://www.mhlw.go.jp/stf/shingi2/0000175125.html]
 
6) NPUAP, EPUAP, PPPIA : Repositioning Techniques. In : Prevention and Treatment of Pressure Ulcers : Quick Reference Guide, 2nd ed, p23-24, Cambridge Media, 2014.
 
7) ISO, ArjoHuntleigh : An edited summary of ISO Technical Report 12296, Ergonomics-Manual handling of people in the healthcare sector, ArjoHuntleigh, 2012 (上田喜敏訳 : 人間工学-ヘルスケア部門の人による徒手的介助, ArjoHuntleigh Japan [http://www.arjohuntleigh.net/jp/default.asp]), 2013.
 
8) ISO : ISO Technical Report 12296, Ergonomics-Manual Handling of People in the Healthcare Sector, ISO, 2012.
 
9) Nelson AL, et al : The Illustrated Guide to Safe Patient Handling and Movement, Springer Publishing Company, New York, 2006.
 
10) 藤澤正一郎, 上田喜敏 : 人間工学的視点から見た安全な患者介助～保健衛生業の腰痛問題～, ライフサポート 22 : 47-50. 2010.
 

XV 老年看護学

P.710 掲載の参考文献
1) OECD Factbook 2009 : Economic, Environmental and Social Statistics, 2009.
 
2) 厚生労働省 : 地域包括ケアシステム [http://www.mhlw.go.jp/stf/seisakunitsuite/bunya/hukushi_kaigo/kaigo_koureisha/chiiki-houkatsu/] (2018年6月閲覧)
 
3) 私たちの街で最期まで, 日本在宅ケアアライアンス, 2017.
 
4) 地域包括ケア研究会報告書-2040年に向けた挑戦-, 地域包括ケアシステム構築に向けた制度及びサービスのあり方に関する研究事業報告書, 2017.
 
5) WHO神戸センター : 高齢化. [http://www.who.int/kobe_centre/ageing/ja/] (2018年6月閲覧)
 
6) World Health Organization : World Report on Ageing and Health 2015.
 
7) Beard JR, et al : The World report on ageing and health : a policy framework for healthy ageing. Lancet 387 (10033) : 2145-2154, 2016.
 
8) 太田喜久子 (編著) : 老年看護学第2版 高齢者の健康生活を支える看護. 医歯薬出版, 2017.
 
9) 福井小紀子, ほか : 系統看護学講座 統合分野 在宅看護論 第5版, 医学書院, 2018.
 
10) 内閣府 : 科学技術イノベーション総合戦略 2017. [http://www8.cao.go.jp/cstp/sogosenryaku/2017/gaiyo2017.pdf] (2018年6月閲覧)
 
11) Ancoli-lsrael S, et al : The role of actigraphy in the study of sleep and circadian rhythms. Sleep 26 : 342-392, 2003.
 
12) Kogure T, et al : Validation of a sheet-shaped body vibrometer for screening of obstructive sleep apnea. Drug Discov Ther 11 : 126-132, 2017.
PubMed
13) 日本病院会 : 2015年度QIプロジェクト結果報告. [https://www.hospital.or.jp/pdf/06_20161020_01.pdf] (2018年6月閲覧)
 
14) 樋口多恵子, ほか : 急性期病院における転倒転落インシデントの分析. 新潟県立中央病院医誌 25 (1) : 11-16, 2017.
Medical*Online
15) Pieper B, Templin TN : Sleep Quality : A Pilot Study Comparing Patients With and Without Injection-Related Venous Ulcers. J Wound Ostomy Continence Nurs 43 : 471-476, 2016.
PubMed
16) Bestvina CM, Polite BN : Implementation of Advance Care Planning in Oncology : A Review of the Literature. J Oncol Pract 13 : 657-662, 2017.
PubMed
P.715 掲載の参考文献
1) 水谷信子監修 : 最新老年看護学 第3版 (水野敏子, ほか編), 日本看護協会出版会, 2018.
 
2) 厚生労働省 : 高齢者の低栄養防止・重症化予防等の推進について, 平成28年9月2日, 2016. [http://www.mhlw.go.jp/file/05-Shingikai-10801000-Iseikyoku-Soumuka/0000135469.pdf] (2018年7月閲覧)
 
3) 厚生労働省 : これからの介護予防. [http://www.mhlw.go.jp/file/06-Seisakujouhou-12300000-Roukenkyoku/0000075982.pdf] (2018年7月閲覧)
 
4) 新開省二, ほか : 群馬県草津町における介護予防10年間の歩みと成果. 日本公衆衛生雑誌 60 (9) : 596-605, 2013.
 
5) Kono A, et al : Effects of an Updated Preventive Home Visit Program Based on a Systematic Structured Assessment of Care Needs for Ambulatory Frail Older Adults in Japan : A Randomized Controlled Trial. J Gerontol A Biol Sci Med Sci 71 : 1631-1637, 2016.
PubMed
6) 厚生労働省 : 平成28年度入院医療等における実態調査, 平成29年6月7日, 2017. [https://www.mhlw.go.jp/file/05-Shingikai-12404000-Hokenkyoku-Iryouka/0000167026.pdf] (2018年7月閲覧)
 
7) Dewing J, et al : What is the current state of care for older people with dementia in general hospitals? Aliterature review. Dementia (London) 15 : 106-124, 2016.
 
8) Siddiqi N, et al : Interventions for preventing delirium in hospitalised non-ICU patients. Cochrane Database Syst Rev 3 : CD005563, 2016.
PubMed
9) 酒井郁子, 金城利雄 (編) : リハビリテーション看護-障害をもつ人の可能性とともに歩む-, 南江堂, pl51, 2010.
 
10) 厚生労働省 : 平成27年 (2015) 医療施設 (動態) 調査・病院報告の概況. [https://www.mhlw.go.jp/toukei/saikin/hw/iryosd/15/dl/gaikyo.pdf] (2018年7月閲覧)
 
11) 山本由子 : 退院後の生活を見据えた高齢者ケアのための知識, 高齢者の特徴. 看護技術 63 (12) : 1120-1125, 2017.
 
12) Rodakowski J, et al : Caregiver Integration During Discharge Planning for Older Adults to Reduce Resource Use : A Metaanalysis. J Am Geriatr Soc 65 : 1748-1755, 2017.
PubMed
13) Nicholson C, et al : Supportive care for older people with frailty in hospital : An integrative review. Int J Nurs, 66 : 60-71, 2017. (doi : 10.1016/j.ijnurstu. 2016.11.015)
 
14) Stanyon MR, et al : The competencies of Registered Nurses working in care homes : amodified Delphi study. Age Ageing, 46 : 582-588, 2017. (doi : 10.1093/ageing/afw244)
 
15) Izumi S, et al : Defining end-of-life care from perspectives of nursing ethics. Nurs Ethics 19 : 608-618, 2012.
 
16) 内閣府 : 平成28年版高齢社会白書, 2016. [http://www8.cao.go.jp/kourei/whitepaper/w-2016/html/zenbun/s1_2_3.html] (2018年7月閲覧)
 
17) 厚生労働省 : 人生の最終段階における医療・ケアの決定プロセスに関するガイドライン, 平成30年3月, 2018. [https://www.mhlw.go.jp/file/04-Houdouhappyou-10802000-Iseikyoku-Shidouka/0000197701.pdf] (2018年7月閲覧)
 
18) Weathers E, et al : Advance care planning : A systematic review of randomised controlled trials conducted with older adults. Maturitas 91 : 101-109, 2016.
PubMed
P.721 掲載の参考文献
1) 亀井智子 : 認知症高齢者のチーム医療と看護 : グッドプラクティスのために. 中央法規出版, 2017.
 
2) 水谷信子 (監修) : 最新老年看護学, 第3版, 日本看護協会出版会, 2016.
 
3) 横浜市立みなと赤十字病院3Dサポートチーム (編) : 3Dサポートチームの事例にみるうつ・せん妄・認知症の人へのアプローチ, サイオ出版, 2015.
 
4) 鶴屋邦江 : 退院支援. 第3章 高齢者の地域での生活を見据える視点, 退院後の生活を見据えた高齢者ケア. 看護技術 63 : 132-138, 2017.
 
5) 健康長寿ネット. [https://www.tyojyu.or.jp/net/byouki/kango/index.html] (2018年7月閲覧)
 
6) 厚生労働省 : 中央社会保険医療協議会総会 (第315回) 議事次第, 入院医療 (その6) について. [http://www.mhlw.go.jp/file/05-Shingikai-12404000-Hokenkyoku-Iryouka/0000105049.pdf] (2018年7月閲覧)
 
7) 正木治恵, 真田弘美 (編) : 老年看護学概論, 南江堂, 2016.
 
8) 田中久美 (編) : 特集 一般病棟における認知症高齢者へのケア. 看護技術 62 : 40-118, 2016.
 
P.724 掲載の参考文献
1) 厚生労働省 : 平成28年介護サービス施設・事業所調査. 2017. [http://www.mhlw.go.jp/toukei/list/24-22-2.html]
 
2) 厚生労働省 : 平成12年介護サービス施設・事業所調査. 2001. [http://www.mhlw.go.jp/toukei/list/24-22-2.html]
 
3) 厚生労働省 : 介護給付費等実態調査 (平成28年4月審査分). 2016. [http://www.mhlw.go.jp/toukei/list/45-1.html]
 
4) 厚生労働省 : 介護給付費等実態調査 (平成13年5月審査分). 2001. [http://www.mhlw.go.jp/toukei/list/45-1.html]
 
5) 厚生労働省 : 平成13年介護サービス施設・事業所調査. 2002. [http://www.mhlw.go.jp/toukei/list/24-22-2.html]
 
6) 日本看護協会 : 介護施設等における看護職員に求められる役割とその体制のあり方に関する調査研究事業報告書. 平成28年度厚生労働省老人保健事業推進費等補助金, 2017.
 
7) Jutkowitz E, et al : Care-Delivery Interventions to Manage Agitation and Aggression in Dementia Nursing Home and Assisted Living Residents : A Systematic Review and Meta-analysis. J Am Geriatr Soc 64 : 477-488, 2016.
PubMed
8) 大河原啓文, 深堀浩樹, 廣岡佳代ほか : 日本の高齢者ケア施設における看取りの質の評価・改善に関する研究の動向. Palliative Care Research 11 : 401-412, 2016.
 
9) 横矢ゆかり, 百瀬由美子 : 看護職の自己評価に焦点を当てた介護老人保健施設における終末期ケアの質評価指標の開発. 日本看護研究学会雑誌 37 : 31-43, 2014.
 
10) 三菱総合研究所 : 介護保険制度におけるサービスの質の評価に関する調査研究事業報告書. 平成29年度厚生労働省老人保健事業推進費等補助金, 2018.
 
11) Sandoval Garrido FA, Tamiya N, Kashiwagi M, et al : Relationship between structural characteristics and outcome quality indicators at health care facilities for the elderly requiring long-term care in Japan from a nationwide survey. Geriatr Gerontol Int 14 : 301-308, 2014.
PubMed
P.728 掲載の参考文献
1) 三菱UFJリサーチ&コンサルティング : 平成29年度老人保健事業推進費等補助金老人保健健康増進等事業「特別養護老人ホームにおける看護職員の役割等に関する調査研究事業」報告書, 平成30年3月.
 
2) 厚生労働省 : 平成28年介護サービス施設・事業所調査の概況, p15, 平成29年9月28日.
 
3) 森幹雄, 小野美喜 : 特別養護老人ホームで働く看護職の専門的自律性に寄与する要因. 日本看護倫理学会誌 6 (1) : 46-52, 2014
 
4) 厚生労働省 : 平成28年人口動態調査 (上巻/5-6/死亡の場所別にみた年次別死亡数百分率)
 
5) 島田千穂, ほか : 特別養護老人ホームにおける看取りケア実施状況と関連要因. 老年社会科学 34 (4) : 500-509, 2013
Medical*Online
6) Ikegami N, Ikezaki S : Japan's policy of promoting end-of-life care in nursing homes : impact on facility and resident characteristics associated with the site of death. Health Policy 105 : 303-311, 2012.
PubMed
7) 井澤玲奈, 水野敏子 : 特別養護老人ホームにおいて最期を迎る利用者への援助. 東京女子医科大学看護学会誌 4 (1) : 29-36, 2009.
 
8) 小林尚司, 山下香枝子 : 特別養護老人ホームの看取りケアにおける看護職員の実践. せいれい看護学会誌 6 (2) : 9-15, 2016.
Medical*Online
9) 大村光代 : 特別養護老人ホームの看取りに求められる介護職に対する看護職の連携能力の因子構造. 日本看護研究学会雑誌 36 (4) : 47-53, 2013.
 
P.732 掲載の参考文献
1) de Lau LM, et al : Incidence of parkinsonism and Parkinson disease in a general population : the Rotterdam Study, Neurology 63 : 1240-1244, 2004.
 
2) ヴァージニア ヘンダーソン (著), (湯槙ます, 小玉香津子翻訳) : 看護の基本となるもの, 日本看護協会出版会, 再新装版, 2016.
 
3) 医療情報科学研究所 (編) : 病気が見えるシリーズ vol. 7 脳, メディックメディア, 2011.
 
4) Merskey H, Bogduk N : IASP Task force on Taxonomy : Classification of Chronic pain, 2nd ed, IASP Press, Seattle, p209-214, 1994.
 
5) 日本神経学会 (監), 「パーキンソン病治療ガイドライン」作成委員会 (編) : パーキンソン病治療ガイドライン 2011, 医学書院, 2011.
 
6) 九州大学大学院医学研究院精神病態医学分野 (2010) せん妄の診断・治療. [http://www.med.kyushu-u.ac.jp/psychiatry/_userdata/delirium(revised).pdf]
 
7) Tuma R, DeAngelis LM : Altered mental status in patients with cancer. Arch Neurol 57 : 1727-1731, 2000.
PubMed
8) Lipowski ZJ : Delirium ; Acute Confusional States. Oxford University Press, New York, 1990.
 
P.736 掲載の参考文献
1) Erikson EH, et al : Vital Involvement in Old Age, w. w. Norton, 1994 (朝長正徳, 朝長梨枝子 (訳) : 老年期-生き生きしたかかわりあい, みすず書房, 1997)
 
2) 冨澤ゆかり, ほか : 脊柱後彎のみられる高齢女性の脊柱後彎の自覚の程度とIndex of Kyphosisによる評価との相違. 日本ニューロサイエンス看護学会誌 2 : 61-68, 2015.
Medical*Online
3) 吉村弥須子, ほか : 身体的変化のある骨粗鬆症患者のQOL : 身長短縮や円背の主観的程度と心理的側面との関連. 日本看護研究学会雑誌 25 : 59-69, 2002.
 
4) 落井祐香里, 磯見智恵 : 脊柱後彎のある高齢者の日常生活上の困難とその対処. 日本看護学会論文集 老年看護39 : 100-102, 2009.
 
5) 福録恵子, 藤田淳子 : 骨粗鬆症患者の良好な睡眠のための工夫および睡眠障害と円背, 疼痛, 活動量との関連. 日本整形外科看護研究会誌 4 : 60-67, 2009.
Medical*Online
6) 永田昌美, ほか : 特別養護老人ホーム入所者における車いす座位の問題点に関する検討. 甲南女子大学研究紀要 (看護学・リハビリテーション学編) 2 : 99-106, 2009.
 
7) 福録恵子, ほか : 脊椎後彎を有する高齢者の転倒予防と活動量増加に効果的なトレーニングプログラムの検討. 日本看護科学学会学術集会講演集 30 : 563, 2010.
 
8) Zimmerman DR : Improving nursing home quality of care through outcomes data : the MDS quality indicators. Int J Geriatr Psychiatry 18 : 250-257, 2003.
PubMed
9) 岩澤由子 : 労働と看護の質向上のためのデータベース (DiNQL) 事業について 労働と看護の質向上のためのデータベース (DiNQL) 事業の全体像. 看護 66 : 16-22, 2014.
 
10) 出口まり子, ほか : 病棟でのデータ活用 転倒・転落防止 病床機能の特徴を生かした転倒・転落防止の取り組み. 看護 69 : 109-115, 2017.
 
11) Morse JM, Morse RM : Tylko, Development of a scale to identify the fall-prone patient. Canadian Journal on Aging, 8 : 366-377, 1989.
 
12) Hendrich AL, et al : Validation of the Hendrich II Fall Risk Model : a large concurrent case/control study of hospitalized patients. Appl Nurs Res 16 : 9-21, 2003.
 
13) Oliver D, et al : Development and evaluation of evidence based risk assessment tool (STRATIFY) to predict which elderly inpatients will fall : case-control and cohort studies. BMJ 315 : 1049-1053, 1997.
PubMed
14) Callis N : Falls prevention : Identification of predictive fall risk factors. Appl Nurs Res 29 : 53-58, 2016.
PubMed
15) 日本看護協会医療・看護安全管理情報. 転倒転落による事故を防ぐ. [https://www.nurse.or.jp/nursing/practice/anzen/pdf/no_9.pdf]
 
16) 東京都病院経営本部 : 転倒・転落防止マニュアル [http://www.byouin.metro.tokyo.jp/hokoku/anzen/documents/jikoyobo0800.pdf] (2018年7月閲覧)
 
17) Herdman TH (原著), 日本看護診断学会 (翻訳) : NANDA-I 看護診断-定義と分類 <2012-2014>, p262, 医学書院, 2012.
 
P.742 掲載の参考文献
1) 鷲尾昌一, ほか : 肺炎球菌ワクチン接種高齢者と非接種高齢者の特徴-福岡県における高齢者肺炎の症例対照研究参加者の解析結果より. 臨牀と研究 93 : 1109-1112, 2016.
Medical*Online
2) 福田友紀子, ほか : 発熱を主訴に入院した後期高齢者の臨床的検討. 順天堂医学 53 : 598-604, 2007.
 
3) 高橋弘毅 : 死亡者数最大の感染症 肺炎, 高齢者の肺炎の特徴. 公衆衛生 74 : 12-14, 2010.
 
4) 河津里沙, ほか : 本邦における結核のリスク集団-人口寄与割合と優先政策に関する検討. 結核 90 : 395-400, 2015.
Medical*Online
5) 柳原博樹 : 介護職の結核感染リスク-高齢者施設の結核集団感染事例の分析. 結核 89 : 631-636, 2014.
Medical*Online
6) 鈴木裕子, ほか : 結核病棟における80歳以上の高齢者の服薬中断リスクの実態調査. 日本看護学会論文集 慢性期看護 45 : 180-183, 2015.
 
7) 鷲尾昌一, ほか : 施設入所高齢者に対するインフルエンザワクチンの効果. 臨牀と研究 88 : 367-370, 2011.
Medical*Online
8) 高山直子, ほか : 地域在住高齢者のインフルエンザ予防ワクチン接種状況と接種行動に与える要因. 臨牀と研究 84 : 1399-1402, 2007.
Medical*Online
9) Usami T, et al : Impact of community pharmacists advocating immunization on influenza vaccination rates among the elderly. Yakugaku Zasshi 129 : 1063-1068, 2009.
PubMed
10) Stark RP, Maki DG : Bacteriuria in the catheterized patient. What quantitative level of bacteriuria is relevant? N Engl J Med 311 : 560-564, 1984.
PubMed
11) 正源寺美穂, ほか : 急性期病院における高齢患者に対する早期排尿自立支援プログラムの効果-尿道カテーテル留置からの離脱と排尿行動の自立にむけた取り組み. 日本創傷・オストミー・失禁管理学会誌 19 : 336-345, 2015.
Medical*Online
12) 日本創傷オストミー失禁管理学会 (編) : 平成28年度診療報酬改定 排尿自立指導料に関する手引き, p21, 照林社, 2016.
 
13) 大塚藤男 : 皮膚の構造と機能. 皮膚科学 第10版, p1-22, 金芳堂, 2016.
 
14) 鈴木周朔, ほか : 高齢者の足部より散布された白癬菌に関する疫学調査. 日本衛生学雑誌 72 : 177-183, 2017.
Medical*Online
15) Campbell JL, et al : Candida albicans colonisation, continence status and incontinence-associated dermatitis in the acute care setting : a pilot study. Int Wound J 14 : 488-495, 2017.
PubMed
16) Foureur N, et al : Prospective aetiological study of diaper dermatitis in the elderly. Br J Dermatol 155 : 941-946, 2006.
PubMed
17) 永倉貢一, ほか : 神奈川県の高齢者関連施設での疥癬発生の実態. 環境感染 16 : 216-219, 2001.
 
18) 大桑麻由美, ほか : 寝たきり高齢者における踵部褥瘡の深達度とABI (ankle brachial index) との関係. 日本褥瘡学会誌 9 : 177-182, 2007.
Medical*Online
19) 厚生労働省 : 平成28年結核登録者情報調査年報集計結果. [http://www.mhlw.go.jp/file/06-Seisakujouhou-10900000-Kenkoukyoku/0000175603.pdf] (2018年7月閲覧)
 
P.747 掲載の参考文献
1) Fukuchi Y, et al : COPD in Japan : the Nippon COPD Epidemiology study. Respirology 9 : 458-465, 2004.
PubMed
2) 吉川雅則, 木村弘 : 合併症 (全身併存症), 栄養障害. 日本内科学会雑誌 101 : 1562-1570, 2012.
 
3) 日本呼吸器学会COPDガイドライン第4版作成委員会 (編) : COPD (慢性閉塞性肺疾患) 診断と治療のためのガイドライン, 第4版, メディカルレビュー社, 2013.
 
4) Pitta, F, et al : Physical activity and hospitalization for exacerbation of COPD. Chest 129 : 536-544, 2006.
PubMed
5) Waschki B, et al : Physical activity is the strongest predictor of all-cause mortality in patients with COPD : a prospective cohort study. Chest 140 : 331-342, 2011.
PubMed
6) Aguilaniu B, Roche N : The difficulties of measuring and improving physical activity in COPD. NPJ Prim Care Respir Med 24 : 14014, 2014
PubMed
7) 亀井智子, ほか : COPD在宅酸素療法実施者への在宅モニタリングに基づくテレナーシング実践の急性増悪および再入院予防効果-ランダム化比較試験による看護技術評価-. 日本看護科学会誌, 31 : 24-33, 2011.
Medical*Online
8) e-STAT政府統計の総合窓口 : 人口動態調査 2016年, 総務省統計局 [https://www.e-stat.go.jp/stat-search/files?page=1&layout=datalist&lid=000001191145] (閲覧 : 2018年4月7日)
 
9) Teramoto S, et al : High incidence of aspiration pneumonia in community-and hospital-acquired pneumonia in hospitalized patients : a multicenter, prospective study in Japan. J Am Geriatr Soc 56 : 577-579, 2008.
PubMed
10) Watando A, et al : Daily oral care and cough reflex sensitivity in elderly nursing home patients. Chest 126 : 1066-1070, 2004.
PubMed
11) 日本摂食・嚥下リハビリテーション学会医療検討委員会 : 日本摂食・嚥下リハビリテーション学会嚥下調整食分類 2013. 日本摂食・嚥下リハビリテーション学会誌 17 (3) : 255-267, 2013
 
12) 菊谷武 : 運動障害性咀嚼障害を伴う高齢者の食形態の決定. 日本補綴歯科学会誌 8 : 126-131, 2016.
Medical*Online
13) 大田健 : 喘息予防・管理ガイドライン (成人喘息). アレルギー 65 (2) : 97-103, 2016.
Medical*Online
14) 福冨友馬, ほか : 本邦における病院通院成人喘息患者の実態調査-国立病院機構ネットワーク共同研究-. アレルギー 59 : 37-46, 2010.
Medical*Online
15) 多賀谷悦子, ほか : 後期高齢者気管支喘息における慢性閉塞性肺疾患合併症例の検討. 日本呼吸器学会誌 1 : 541-547, 2012.
Medical*Online
P.752 掲載の参考文献
1) 新老年学, 第3版 (大内尉義, 秋山弘子編集代表), 東京大学出版会, p659-661, 2010.
 
2) Epidemiologic and methodologic problems in determining nutritional status of older persons. Am J Clin Nutr 50 : 1121-1235, 1989.
PubMed
3) Cruz-Jentoft AJ, et al : Sarcopenia : European consensus on definition and diagnosis : Report of the European Working Group on Sarcopenia in Older People. Age Ageing 39 : 412-423, 2010
 
4) Nakamura K : A "super-aged" society and the "locomotive syndrome". J Orthop Sci 13 : 1-2, 2008.
PubMed
5) 松嶋康之, 蜂須賀研二 : 廃用症候群 定義, 病態. 総合リハビリテーション 41 : 257-262, 2013.
 
6) Halar EM, et al : Myopathy. In : Physical Medicine and Rehabilitation (ed by DeLisa JA), p1447-1467, Lippincott Williams and Wilkins, Philadelphia, 2005.
 
7) 若林秀隆 : 高齢者の廃用症候群の機能予後とリハビリテーション栄養管理. 静脈経腸栄養 28 : 1045-1050, 2013.
 
P.757 掲載の参考文献
1) 内閣府政策統括官 (共生社会政策担当) : 高齢者の地域社会への参加に関する意識調査結果報告書 平成26年3月, p11-12, 内閣府, 2014.
 
2) 秋山雅弘 : 5. 老化の概念. 老年医学系統講義テキスト (日本老年医学会編), p26-27, 西村書店, 2013.
 
3) 山田律子 : 認知症の人の食事支援 BOOK-食べる力を発揮できる環境づくり, p42-54, 中央法規出版, 2013.
 
P.763 掲載の参考文献
1) 谷口珠実 : アセスメントとそのポイント. 排泄ケアガイドブック (日本創傷・オストミー・失禁管理学会編), p30-50, 照林社, 2017.
 
2) 日本排尿機能学会 (編) : 夜間頻尿診療ガイドライン, p49, Blackwell Publishing, 2009.
 
3) 日本排尿機能学会 (編) : 女性下部尿路症状診療ガイドライン, p6-10, RichHill Medical, 2013
 
4) 日本泌尿器科学会 (編) : 定義と解説. 男性下部尿路症状・前立腺肥大症診療ガイドライン. p41-48, RichHill Medical. 2013.
 
5) 日本排尿機能学会 : 排尿日誌. [http://japanese-continence-society.kenkyuukai.jp/images/sys%5Cinformation%5C20150223164317-BF77A4DB19B41F63FAFE8E4B30585E78048FID63EAO708B19559919364A33550.pdf] (2018年7月閲覧)
 
6) 谷口珠実 : 排尿のアセスメント. 下部尿路機能障害の治療とケア (谷口珠実, 武田正之編), p124-141, メディカ出版, 2017.
 
7) 一般社団法人日本創傷・オストミー・失禁管理学会 (編) : 平成28年度診療報酬改定「排尿自立指導料」に関する手引き, p19, 照林社, 2016.
 
8) 日本消化器病変学会関連研究会 (編) : 慢性便秘症診療ガイドライン, p2, 南江堂, 2017.
 
9) 穴澤貞夫, ほか (編) : 排泄リハビリテーション理論と臨床, p81-87, 中山書店, 2009.
 
10) 日本大腸肛門病学会 (編) : 便失禁診療ガイドライン 2017年版, p2, p56-63, 南江堂, 2017.
 
P.768 掲載の参考文献
1) Reiber GE, et al : The burden of diabetic foot ulcers. Am J Surg 176 (2A Suppl) : 5S-10S, 1998.
 
2) Singh N, et al : Preventing foot ulcers in patients with diabetes. JAMA 293 : 217-228, 2005.
PubMed
3) Boyko EJ, et al : Increased mortality associated with diabetic foot ulcer. Diabet Med 13 : 967-972, 1996.
PubMed
4) Lee JS, et al : Lower-extremity amputation. Incidence, risk factors, and mortality in the Oklahoma Indian Diabetes Study. Diabetes 42 : 876-882, 1993.
PubMed
5) International Working Group on the Diabetic Foot : Guidance for prevention 2015. [http://iwgdf.org/guidelines/guidance-for-prevention-2015/] (2018年7月閲覧)
 
6) Peters EJ, Lavery LA : Effectiveness of the diabetic foot risk classification system of the International Working Group on the Diabetic Foot. Diabetes Care 24 : 1442-1447, 2001.
 
7) Oe M, et al : incidence of foot ulcers in patients with diabetes at a university hospital in Tokyo over a 5-year period. Diabetology International 6 (1) : 55-59, 2015.
 
8) Nishide K, et al : Ultrasonographic and thermographic screening for latent inflammation in diabetic foot callus. Diabetes Res Clin Pract 85 : 304-309, 2009.
PubMed
9) Oe M, et al : Thermographic findings in a case of type 2 diabetes with foot ulcer due to callus deterioration. Diabetology International 8 (3) : 328-333, 2017.
 
10) Steed DL, et al : Guidelines for the treatment of diabetic ulcers. Wound Repair Regen 14 : 680-692, 2006.
PubMed
11) 市岡滋, 寺師浩人 : Wound Healing Societyによる静脈性潰瘍/糖尿病性潰瘍/動脈不全潰瘍に対する治療&予防のガイドライン 糖尿病性潰瘍治療のガイドライン. 足の創傷をいかに治すか-糖尿病フットケア・Limb Salvageへのチーム医療-, p18-31, 克誠堂出版, 2009.
 
12) Arisandi D, et al : Evaluation of validity of the new diabetic foot ulcer assessment scale in Indonesia. Wound Repair Regen 24 : 876-884, 2016.
PubMed
13) Terashi H, et al : Total management of diabetic foot ulcerations-Kobe classification as a new classification of diabetic foot wounds. Keio J Med 60 : 17-21, 2011.
PubMed
P.772 掲載の参考文献
1) Kim K, et al : An epidemiological study of insomnia among the Japanese general population. Sleep 23 : 41-47, 2000.
 
2) 厚生労働省健康局 : 健康づくりのための睡眠指針 2014. [http://www.mhlw.go.jp/file/06-Seisakujouhou-10900000-Kenkoukyoku/0000047221.pdf]
 
3) 尾崎章子, 巽あさみ : 健康づくりのための睡眠指針 2014～睡眠12箇条～に基づいた保健指導ハンドブック, 厚生労働科学研究費補助金, 健康日本 21 (第2次) に即した睡眠指針への改訂に資するため の疫学研究 (代表 : 兼板佳孝), 2016.
 
4) Qaseem A, et al : Management of Chronic Insomnia Disorder in Adults : A Clinical Practice Guideline From the American College of Physicians. Ann Intern Med 165 : 125-133, 2016.
PubMed
5) 厚生労働科学研究・障害者対策総合研究事業「睡眠薬の適正使用及び減量・中止のための診療ガイドラインに関する研究班」および日本睡眠学会・睡眠薬使用ガイドライン作成ワーキンググループ (編) : 睡眠薬の適正な使用と休薬のための診療ガイドライン-出口を見据えた不眠医療マニュアル-, 2013. [http://www.jssr.jp/data/pdf/suiminyaku-guideline.pdf]
 
6) 小曽根基裕, ほか : 睡眠薬による平衡機能への影響-最も有効な転倒防止策は何か? 日本薬物脳波学会雑誌 10 : 13-20, 2009.
 
7) 稲見康司, ほか : 高齢者の睡眠医療における薬物療法の功罪-依存と副作用について-. Geriatric Medicine 48 : 791-794, 2010.
Medical*Online
8) Wagner AK, et al : Benzodiazepine use and hip fractures in the elderly : who is at greatest risk? Arch Intern Med 164 : 1567-1572, 2004.
PubMed

XVI 学際的立場からの高齢者医療・介護

P.786 掲載の参考文献
1) 白澤政和 : ケアマネジメントの本質生活支援のあり方と実践方法, 中央法規, 2018.
 
2) 2訂/介護支援専門員研修テキスト編集委員会 (編) : 2訂/介護支援専門員研修テキスト主任介護支援専門員更新研修, 一般社団法人日本介護支援専門員協会, 2018.
 
3) 日本医師会編 : かかりつけ医のための認知症マニュアル, 社会保険研究所, 2015.
 
P.792 掲載の参考文献
1) 内閣府 : 医療・介護情報の活用による改革の推進に関する専門調査会 : 第5回資料, 2015年6月15日.
 
2) 松田晋哉, ほか : 医療・介護レセプト連結データを用いた脳梗塞患者の医療介護サービス利用状況の分析. 社会保険旬報 2703 : 26-31, 2018.
 
3) 松田晋哉, ほか : 施設系介護サービス利用の時系列分析, 社会保険旬報 2705 : 16-21, 2018.
 
4) 地域別人口変化分析ツール All Japan Areal Population-change Analyses (AJAPA) : [https://sites.google.com/site/pmchuoeh/oshirase/ajapa]
 
5) 松田晋哉 : 地域医療構想をどう策定するか, 医学書院, 2015.
 
6) 日本創成会議 首都圏問題検討分科会 : 東京圏高齢化危機回避戦略 一都三県連携し, 高齢化問題に対応せよ, 2015年6月4日. [http://www.policycouncil.jp/pdf/prop04/prop04.pdf] (2018年7月閲覧)
 
7) 松田晋哉 : 地域医療構想と民間病院 (2) 医療法人ふらて会西野病院 病院の持つ「安心保障機能」の地域への開放・社会化の実践. 病院 75 (2) : 134-140, 2016.
 
8) 松田晋哉 : 地域医療構想と民間病院 (3) 医療法人博仁会 志村大宮病院-地域リハビリテーションのネットワーク構築を通したまちづくりへの積極的参画と地域共生型CCRCの提案. 病院 75 (3) : 211-218, 2016.
 
9) 松田晋哉 : 地域医療構想と民間病院 (4) 社会医療法人社団陽正会 寺岡記念病院-コモンズの創設の試みとスローメディシンの実践. 病院 75 (4) : 295-300, 2016.
 
10) 松田晋哉 : 地域医療構想と民間病院 (5) 医療法人和香会 倉敷スイートホスピタル-ホスピタリティ経営の実践. 病院 75 (5) : 368-373, 2016.
 
11) 松田晋哉 : 地域医療構想と民間病院 (7) 社会医療法人財団董仙会 恵寿総合病院-施設品質から地域品質へ : 変化の先頭に立つ経営. 病院 75 (7) : 536-543, 2016.
 
12) 二木立 : 保健・医療・福祉複合体-全国調査と将来予測-. 医学書院, 1998.
 
13) 地域医療連携推進法人 尾三会 [http://bisankai.or.jp/] (2018年7月閲覧)
 
P.797 掲載の参考文献
1) 日本老年社会科学会ホームページ. [http://www.rounenshakai.org/] (2018年7月閲覧)
 
2) 国立長寿医療研究センター ホームページ. [http://www.ncgg.go.jp/cgss/documents/CGSS2015.pdf] (2018年7月閲覧)
 
3) 厚生労働省老健局 : 介護予防に関する事業の実施に向けての実務者会議資料. 2005. 10. 27.
 
4) 竹内孝仁 : 閉じこもり・閉じこもり症候群. 介護予防研修テキスト, p128-140, 社会保険研究所, 2001.
 
5) 厚生労働省「閉じこもり予防・支援マニュアル」分担研究班 : 閉じこもり予防・支援マニュアル (改訂版). 平成21年3月. [http://www.mhlw.go.jp/topics/2009/05/dl/tp0501-1g.pdf] (2018年7月閲覧)
 
6) 厚生労働省, 厚生科学審議会地域保健健康増進栄養部会次期国民健康づくり運動プラン策定専門委員会 : 健康日本 21 (第2次) の推進に関する参考資料. 平成24年7月. [http://www.mhlw.go.jp/bunya/kenkou/dl/kenkounippon21_02.pdf] (2018年7月閲覧)
 
7) WHO : The uses of epidemiology in the study of the elderly. WHO Technical Report Series 706, p52-54, Geneva, 1984.
 

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