新しい薬疹

出版社： 文光堂
著者：
発行日： 2019-11-10
分野： 臨床医学：内科  >  皮膚科
ISBN： 9784830634710
電子書籍版： 2019-11-10 （第1版第1刷）
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商品紹介

近年，生物学的製剤や分子標的薬，免疫チェックポイント阻害薬などの薬剤が登場し，従来にはなかった新しいタイプの薬疹が報告されている．本書では様々な原因薬別にその発生機序，症状，対処法について詳細に解説した．臨床写真がふんだんに掲載されており，アトラスとしても利用できる．皮膚科医はもちろん，原因薬剤を処方した一般内科医にも役立つ内容となっており，これまでになかった1冊となった．

目次

  • 序説　薬疹から皮膚有害事象へ

    第I章　薬剤による皮膚有害事象
    A　分子標的薬による皮膚有害事象
    　1　分子標的薬による痤瘡とその治療
    　2　分子標的薬による手足症候群とその治療
    　3　分子標的薬による爪囲炎とその治療
    　4　タキサン系薬剤による皮膚障害
    　COLUMN　抗がん剤漏出の対処法
    B　メラノーマ・リンフォーマ治療薬による皮膚有害事象
    　1　抗PD-1抗体，抗CTLA-4抗体による皮膚障害
    　2　BRAF阻害薬，MEK阻害薬による皮膚障害
    　3　抗CCR4抗体による皮膚障害
    　COLUMN　抗CCR4抗体による光線過敏症
    C　乾癬治療薬による皮膚有害事象
    　1　生物学的製剤による投与時反応
    　2　TNF-α阻害薬による逆説的反応
    　3　生物学的製剤による皮膚感染症
    　4　生物学的製剤による脱毛症
    　COLUMN　急性汎発性発疹性膿疱症と膿疱性乾癬
    　COLUMN　抗IL-4/IL-13受容体抗体による結膜炎
    D　特殊な薬剤による皮膚障害
    　1　DPP-4阻害薬による水疱性類天疱瘡
    　2　漢方薬による皮膚障害
    　3　セツキシマブによるアレルギー
    　4　ヒドロキシクロロキンによる薬疹
    　5　ワルファリンによる皮膚障害
    　COLUMN　G-CSF製剤によるSweet症候群

    第II章　薬剤による特殊な皮膚障害
    　1　近年の薬剤性光線過敏症
    　2　ボリコナゾールによる光線関連皮膚癌
    　3　ハイドロキシウレアによる皮膚潰瘍
    　4　薬剤による皮膚硬化
    　5　メトトレキサートとリンパ増殖異常症
    　6　免疫グロブリン大量静注療法による汗疱状皮疹
    　7　インスリン注射部位の硬結（インスリンボール）
    　COLUMN　苔癬型薬疹：最近の原因薬

    第III章　有害事象の発生機序
    　1　イミキモドの免疫変調作用
    　2　EBウイルス感染症と薬疹
    　3　Stevens-Johnson症候群/中毒性表皮壊死症の免疫異常
    　4　DIHSにおけるウイルス再活性化と自己免疫疾患
    　5　固定薬疹の発症機序－resident memory T細胞を含めて－

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第I章 薬剤による皮膚有害事象

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20) Riley K, et al : Assessment of Antimalarial Therapy in Patients Who Are Hypersensitive to Hydroxychloroquine. JAMA Dermatol 155 ; 491-493, 2019
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21) Gonzalez CD, et al : Adverse cutaneous drug reactions with antimalarials in cutaneous lupus and dermatomyositis : A retrospective cohort study. J Am Acad Dermatol 81 : 859-860, 2019
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22) Soria A, et al : Cutaneous Adverse Drug Reactions with Antimalarials and Allergological Skin Tests. Dermatology 231 : 353-359, 2015
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23) Matsuda T, et al : Early cutaneous eruptions after oral hydroxychloroquine in a lupus erythematosus patient : A case report and review of the published work. J Dermatol 45 : 344-348, 2018
 
24) Coulombe J, Boccara O : Hydroxychloroquine-related skin discoloration. CMAJ 189 : E212, 2017
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1) Nazarian RM, et al : Warfarin-induced skin necrosis. J Am Acad Dermatol 61 : 325-332, 2009
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2) Klein L, et al : Warfarin-induced limb gangrene in the setting of lung adenocarcinoma. Am J Hematol 76 : 176-179, 2004
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3) Hamada T, et al : Warfarin-induced skin necrosis accompanied by aggravation of vasculitis in a patient with cutaneous arteritis. Int J Dermatol 56 : 779-781, 2017
 
4) 長谷川元 : 透析患者に対するワーファリン使用に関する諸問題 有効性と危険性, Calciphylaxis , ワーファリン皮膚壊死, ワーファリン関連腎症. 日血管外会誌 26 : 83-90, 2017
 
5) 中村考伸, ほか : Calciphylaxis によると考えられた陰茎壊死の1例. Skin Surg 19 : 98-102, 2010
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6) 林松彦, ほか : 全国調査に基づくカルシフィラキシス診断基準の提案. 日透析医学会誌 45 : 551-557, 2012
 
7) 渡邉萌理, ほか : Deep dissecting hematomaの1例. 皮膚臨床 56 : 683-686 , 2014
 
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1) Nelson CA, et al : Neutrophilic dermatoses : Pathogenesis, Sweet syndrome, neutrophilic eccrine hidradenitis, and Behcet disease. J Am Acad Dermatol 79 : 987-1006, 2018
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2) Filosa A, Filosa G : Neutrophilic dermatoses : a broad spectrum of disease. G Ital Dermatol Venereol 153 : 265-272, 2018
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3) Nelson CA, et al : Sweet syndrome in patients with and without malignancy : A retrospective analysis of 83 patients from a tertiary academic referral center. J Am Acad Dermatol 78 : 303-309, 2018
 
4) Giasuddin AS, et al : Sweet's syndrome : is the pathogenesis mediated by helper T cell type 1 cytokines? J Am Acad Dermatol 39 : 940-943, 1998
 
5) von den Driesch P : Sweet's syndrome (acute febrile neutrophilic dermatosis). J Am Acad Dermatol 31 : 535-556, 1994
 
6) Walker DC, Cohen PR : Trimethoprim-sulfamethoxazoleassociated acute febrile neutrophilic dermatosis : case report and review of drug-induced Sweet's syndrome. J Am Acad Dermatol 34 : 918-923, 1996
 
7) Nofal A, et al : Sweet's syndrome : diagnostic criteria revisited. J Dtsch Dermatol Ges 15 : 1081-1088, 2017
 

第II章 薬剤による特殊な皮膚障害

P.111 掲載の参考文献
1) Ozaki C, et al : Case of photosensitivity after the administration of olmesartan medoxomil. J Dermatol 45 : e277-e278, 2018
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2) Masuoka E, et al : Dysfunction of melanocytes in photoleukomelanoderma following photosensitivity caused by hydrochlorothiazide. Photodermatol Photoimmunol Photomed 27 : 328-330, 2011
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3) Kunisada M, et al : Hydrochlorothiazide enhances UVA-induced DNA damage. Photochem Photobiol 89 : 649-654, 2013
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4) Pedersen SA, et al : Hydrochlorothiazide use and risk of nonmelanoma skin cancer : A nationwide case-control study from Denmark. J Am Acad Dermatol 78 : 673-681, 2018
 
5) Luu M, et al : Photosensitive rash due to the epidermal growth factor receptor inhibitor erlotinib. Photodermatol Photoimmunol Photomed 23 : 42-45, 2007
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6) Fukai T, et al : Case of erlotinib-induced photosensitivity. J Dermatol 41 : 445-446, 2014
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7) Papakonstantinou E, et al : Pirfenidone-induced severe phototoxic reaction in a patient with idiopathic lung fibrosis. J Eur Acad Dermatol Venereol 30 : 1354-1356, 2016
 
8) Goyal RK : Voriconazol-associated phototoxic dermatoses and skin cancer. Expert Rev Anti Infect Ther 13 : 1537-1546, 2015
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9) Ikeya S, et al : Voriconazole-induced photocarcinogenesis is promoted by aryl hydrocarbon receptor-dependent COX-2 upregulation. Sci Rep 22 : 5050, 2018
 
10) Kuwatsuka S, et al : Case of photosensitivity caused by fenofibrate after photosensitization to ketoprofen. J Dermatol 43 : 224-225, 2016
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11) Hong JH, et al : Fenofi brate-Induced Photosensitivity-A Case Report and Literature Review. Dermatol Sinica 27 : 37-43, 2009
 
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1) Herbrecht R, et al : Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis. N Engl J Med 347 : 408-415, 2002
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2) Johnson LB, Kauffman CA : Voriconazole : a new triazole antifungal agent. Clin Infect Dis 36 : 630-637, 2003
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3) Ratushny V, et al : From keratinocyte to cancer : the pathogenesis and modeling of cutaneous squamous cell carcinoma. J Clin Invest 122 : 464-472, 2012
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4) Williams K, et al : Voriconazole-associated cutaneous malignancy : a literature review on photocarcinogenesis in organ transplant recipients. Clin Infect Dis 58 : 997-1002, 2014
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5) McCarthy KL, et al : Severe photosensitivity causing multifocal squamous cell carcinomas secondary to prolonged voriconazole therapy. Clin Infect Dis 44 : e55-56, 2007
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6) Cowen EW, et al : Chronic phototoxicity and aggressive squamous cell carcinoma of the skin in children and adults during treatment with voriconazole. J Am Acad Dermatol 62 : 31-37, 2010
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7) Tang H, et al : Voriconazole exposure and risk of cutaneous squamous cell carcinoma among lung or hematopoietic cell transplant patients : A systematic review and meta-analysis. J Am Acad Dermatol 80 : 500-507, 2019
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8) Hyland R, et al : Identification of the cytochrome P450 enzymes involved in the N-oxidation of voriconazole. Drug Metab Dispos 31 : 540-547, 2003
 
9) Ona K, Oh DH : Voriconazole N-oxide and its ultraviolet B photoproduct sensitize keratinocytes to ultraviolet A. Br J Dermatol 173 : 751-759, 2015
 
10) Ikeya S, et al : Voriconazole-induced photocarcinogenesis is promoted by aryl hydrocarbon receptor-dependent COX-2 upregulation. Sci Rep 8 : 5050, 2018
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11) 戸倉新樹 : 光線過敏型薬疹. 最新皮膚科学体系 第5巻 (1版), 玉置邦彦編. 中山書店, P75-82, 2004
 
12) Fukushima A, et al : A Case of Cutaneous Squamous Cell Carcinoma Suspected to Be Induced by Voriconazole Phototoxicity. Jpn J Dermatol 126 : 411-418, 2016
 
13) Tone J, et al : Two Cases of Rapidly Progressive Squamous Cell Carcinomas Emerging during Long-term Voriconazole Therapy. J Environ Dermatol Cutan Allergol 10 : 29-34, 2016
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14) Epaulard O, et al : A multistep voriconazole-related phototoxic pathway may lead to skin carcinoma : results from a French nationwide study. Clin Infect Dis 57 : e182-188, 2013
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16) Stockinger B, et al : The aryl hydrocarbon receptor : multitasking in the immune system. Annu Rev Immunol 32 : 403-432, 2014
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18) van den Bogaard EH, et al : Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis. J Clin Invest 123 : 917-927, 2013
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2) 本間大, 飯塚一 : ヒドロキシカルバミド (ハイドレア(R)) による皮膚潰瘍. 皮膚臨床 54 (臨増) : 1583-1587, 2012
 
3) 畠清彦 (監) : ハイドレア(R) カプセルを服用される患者さまへ. ブリストル・マイヤーズ スクイブ, 2016 (https://www.bms.com/assets/bms/japan/documents/11-27-17/HDpatient1607.pdf)
 
4) Simeonovski V, et al : Hydroxyurea Associated Cutaneous Lesions : A Case Report. Open Access Maced J Med Sci 6 : 1458-1461, 2018
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12) 東前和奈, ほか : ハイドロキシウレアによる皮膚潰瘍 : 薬剤中止後にも症状が再燃した1例. 皮の科 12 : 74-78, 2013
 
13) 矢野有沙, ほか : ハイドロキシウレアの投与中に生じた難治性皮膚潰瘍部に有棘細胞癌およびボーエン病を合併した1例. Skin Cancer 32 : 39-43, 2017
 
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5) Clark JG, et al : Bleomycin-induced synthesis of type I procollagen by human lung and skin fibroblasts in culture. Biochim Biophys Acta 631 : 359-370, 1980
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6) Motegi S, et al : Role of endothelin-1/endothelin receptor signaling in fibrosis and calcification in nephrogenic systemic fibrosis. Exp Dermatol 23 : 664-669, 2014
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7) Okada K, et al : Glycosaminoglycan and versican deposits in taxane-induced sclerosis. Br J Dermatol 173 : 1054-1058, 2015
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8) Battafarano DF, et al : Docetaxel (Taxotere) associated scleroderma-like changes of the lower extremities. A report of three cases. Cancer 76 : 110-115, 1995
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10) Farrant PB, et al : Scleroderma and the taxanes. Is there really a link? Clin Exp Dermatol 29 : 360-362, 2004
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13) Winkelmann RR, et al : Paclitaxel-induced diffuse cutaneous sclerosis : a case with associated esophageal dysmotility, Raynaud' s phenomenon, and myositis. Int J Dermatol 55 : 97-100, 2016
 
14) Bessis D, et al : Gemcitabine-associated scleroderma-like changes of the lower extremities. J Am Acad Dermatol 51 (2 Suppl) : S73-S76, 2004
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第III章 有害事象の発生機序

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