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医学と薬学　78/8　2021年8月号

出版社：	自然科学社
発行日：	2021-07-27
分野：	薬学 > 雑誌
ISSN：	03893898
雑誌名：	医学と薬学
特集：	川崎病―基礎と臨床の最前線
電子書籍版：	2021-07-27 （第1版第1刷）

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目次

特集　川崎病―基礎と臨床の最前線

序文
川崎病の疫学―近年の動向
川崎病の遺伝要因
川崎病血管炎の動物モデル
川崎病の病理アップデート―心血管病変を中心に
川崎病診断の手引き改訂6版―改訂のねらい
川崎病急性期治療のガイドライン―改訂のポイント
2020年改訂版　川崎病心臓血管後遺症の診断と治療に関するガイドライン―改訂のポイントコロナウイルス感染症と川崎病

Diagnosis
　WesTMを用いた自動ウエスタンブロットによる
　　橋本脳症の診断バイオマーカー（抗NAE抗体）の測定系開発

Health Care
　バサルトストーントリートメントによる身体・肌への影響に関する検証試験

この書籍の参考文献

参考文献のリンクは、リンク先の都合等により正しく表示されない場合がありますので、あらかじめご了承下さい。

本参考文献は電子書籍掲載内容を元にしております。

【特集川崎病 - 基礎と臨床の最前線】

P.916 掲載の参考文献

1) 川崎富作 : 指趾の特異的落屑を伴う小児の急性熱性皮膚粘膜淋巴腺症候群 : 自験例50例の臨床的観察. アレルギー 16 : 178-222, 1967.

2) 川崎病全国調査担当グループ : 第25回川崎病全国調査成績. https://www.jichi.ac.jp/dph/wp-dph/wp-content/uploads/2020/09/e2e27b17833a88e-36bf2008d23c9e385.pdf

3) Kobayashi T, Ayusawa M, Suzuki H, et al : Revision of diagnostic guidelines for Kawasaki disease. Pediatr Int 62 : 1135-1138, 2020.

4) 小佐見光樹, 屋代真弓, 牧野伸子, 他 : 第25回川崎病全国調査成績. 小児科診療 83 : 269-273, 2020.

5) Ae R, Makino N, Kosami K, et al : Epidemiology, treatments, and cardiac complications in patients with Kawasaki disease : The nationwide survey in Japan, 2017-2018. J Pediatr 225 : 23-29.e2, 2020.

6) Nakamura Y, Yashiro M, Yamashita M, et al : Cumulative incidence of Kawasaki disease in Japan. Pediatr Int 60 : 19-22, 2018.

7) Sano T, Makino N, Aoyama Y, et al : Temporal and geographical clustering of Kawasaki disease in Japan : 2007-2012. Pediatr Int 58 : 1140-1145, 2016.

8) Fujita Y, Nakamura Y, Sakata K, et al : Kawasaki disease in families. Pediatrics 84 : 666-669, 1989.

9) Uehara R, Yashiro M, Nakamura Y, et al : Parents with history of Kawasaki disease whose child also had the same disease. Pediatr Int 53 : 511-514, 2011.

10) Sudo D, Nakamura Y : Nationwide surveys show that the incidence of recurrent Kawasaki disease in Japan has hardly changed over the last 30 years. Acta Paediatr 106 : 796-800, 2017.

11) Sudo D, Makino N, Nakamura Y : Recurrent Kawasaki disease and cardiac complications : nationwide surveys in Japan. Arch Dis Child 105 : 848-852, 2020.

12) Makino N, Nakamura Y, Yashiro M, et al : Epidemiological observations of Kawasaki disease in Japan, 2013-2014. Pediatr Int 60 : 581-587, 2018.

13) Goto T, Sano T, Kojo T, et al : Time course of cardiac lesions due to Kawasaki disease in Japan : 22nd nationwide survey (2011-2012). Pediatr Int 58 : 1274-1276, 2016.

14) Kuwabara M, Yashiro M, Kotani K, et al : Cardiac lesions and initial laboratory data in Kawasaki disease : a nationwide survey in Japan. J Epidemiol 25 : 189-193, 2015.

15) Ae R, Abrams JY, Maddox RA, et al : Platelet count variation and risk for coronary artery abnormalities in Kawasaki disease. Pediatr Infect Dis J 30 : 197-203, 2020.

16) Nakamura Y, Aso E, Yashiro M, et al : Mortality among Japanese with a history of Kawasaki disease : results at the end of 2009. J Epidemiol 23 : 429-434, 2013.

17) Ae R, Abrams JY, Maddox RA, et al : Corticosteroids added to initial intravenous immunoglobulin treatment for the prevention of coronary artery abnormalities in high-risk patients with Kawasaki Disease. J Am Heart Assoc 9 : e015308, 2020.

P.922 掲載の参考文献

1) Onouchi Y : Molecular Genetics of Kawasaki disease. Pediatric Res 65 : 46R-54R, 2009.

2) Onouchi Y, Tamari M, Takahashi A, et al : A genomewide linkage analysis of Kawasaki disease : evidence for linkage to chromosome 12. J Hum Genet 52 : 179-190, 2007.

3) Onouchi Y, Gunji T, Burns JC, et al : ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms. Nat Genet 40 : 35-42, 2008.

4) Onouchi Y, Ozaki K, Burns JC, et al : Common variants in CASP3 confer susceptibility to Kawasaki disease. Hum Mol Genet 19 : 2898-2906, 2010.

5) Onouchi Y, Fukazawa R, Yamamura K, et al : Variations in ORAI1 Gene Associated with Kawasaki Disease. PLoS One 11 : e0145486, 2016.

6) Khor CC, Davila S, Breunis WB, et al : Genomewide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. Nat Genet 43 : 1241-1246, 2011.

7) Onouchi Y, Ozaki K, Burns JC, et al : A genomewide association study identifies three new risk loci for Kawasaki disease. Nat Genet 44 : 517-521, 2012.

8) Lee YC, Kuo HC, Chang JS, et al : Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis. Nat Genet 44 : 522-525, 2012.

9) Johnson TA, Mashimo Y, Wu JY, et al : Association of an IGHV3-66 gene variant with Kawasaki disease. J Hum Genet 66 : 475-489, 2021.

10) Onouchi Y, Suzuki Y, Suzuki H, et al : ITPKC and CASP3 polymorphisms and risks for IVIG unresponsiveness and coronary artery lesion formation in Kawasaki disease. Pharmacogenomics J 13 : 52-59, 2013.

11) Thiha K, Mashimo Y, Suzuki H, et al : Investigation of novel variations of ORAI1 gene and their association with Kawasaki disease. J Hum Genet 64 : 511-519, 2019.

12) Suzuki H, Terai M, Hamada H, et al : Cyclosporin A treatment for Kawasaki disease refractory to initial and additional intravenous immunoglobulin. Pediatr Infect Dis J 30 : 871-876, 2011.

13) Hamada H, Suzuki H, Onouchi Y, et al : Efficacy of primary treatment with immunoglobulin plus ciclosporin for prevention of coronary artery abnormalities in patients with Kawasaki disease predicted to be at increased risk of non-response to intravenous immunoglobulin (KAICA) : a randomised controlled, open-label, blinded-endpoints, phase 3 trial. Lancet 393 : 1128-1137, 2019.

14) 三浦大, 鮎澤衛, 伊藤秀一, 他 : 日本小児循環器学会川崎病急性期治療のガイドライン (2020年改訂版). 日本小児循環器学会雑誌 36 (Suppl 1) : 1-29, 2020.

P.929 掲載の参考文献

1) Murata H : Experimental Candida-induced arteritis in mice. Relation to arteritis in the mucocutaneous lymph node syndrome. Microbiol Immunol 23 : 825-831, 1979.

2) Lehman TJA, Walker SM, McCurdy D, et al : Coronary arteritis in mice following the systemic injection of group B Lactobacillus casei cell walls in aqueous suspension. Arthritis Rheum 28 : 652-659, 1985.

3) Nishio H, Sueishi K, Hara T, et al : Nod1 ligands induce site-specific vascular inflammation. Arterioscler Thromb Vasc Biol 31 : 1093-1099, 2011.

4) 村田久雄 : 川崎病の実験モデル. 日本臨床 41 : 2075-2079, 1983.

5) Ohno N : chemistry and biology of angitis inducer, Candida albicans water-soluble mannoprotein-beta-glucan complex (CAWS). Microbiol Immunol 47 : 479-490, 2003.

6) Tanaka H, Yanai C, Ohno N, et al : Coronary vasculitis induced in mice by cell wall mannoprotein fractions of clinically isolated Candida species. Med Mycol J 61 : 33-48, 2020.

7) Takahashi K. Oharaseki T, Naoe S, et al : Histopathological features of murine systemic vasculitis caused by Candida albicans extract-an animal model of Kawasaki disease-. Inflamm Res 53 : 72-77, 2004.

8) Nagi-Miura N, Oharaseki T, Ohno N, et al : Induction of coronary arteritis with administration of CAWS (Candida albicans water-soluble fraction) depending on mouse strain. Immunopharmacol Immunotoxicol 26 : 527-543, 2004.

9) Oharaseki T, Kameoka Y, Naoe S, et al : Susceptibilitiy loci to coronary arteritis in animal model of Kawasaki disease induced with Candida albicans-derived substances. Microbiol Immunol 49 : 181-189, 2005.

10) Tada R, Miura N, Ohno N, et al : The influence of culture conditions on vasculitis and anaphylactoid shock induced by fungal pathogen Candida albicans cell wall extract in mice. Microb Pathog 44 : 379-388, 2008.

11) Hirata N, Ishibashi K, Ohno N, et al : β-mannosyl linkages inhibit CAWS arteritis by negatively regulating dectin-2-dependent signaling in spleen and dendritic cells. Immunopharmacol Immunotoxicol 35 : 594-604, 2013.

12) Oharaseki T, Yokouchi Y, Takahashi K, et al : Recognition of alpha-mannan by dectin 2 is essential for onset of Kawasaki disease-like murine vasculitis induced by Candida albicans cell-wall polysaccharide. Mod Rheumatol 30 : 350-357, 2020.

13) Miyabe C, Miyabe Y, Bricio-Moreno L, et al : Dectin-2-induced CCL2 production in tissue-resident macrophages ignites cardiac arteritis. J Clin Invest 129 : 3610-3624, 2019.

14) Takahashi K, Oharaseki T, Suzuki K, et al : Administraion of human immunoglobulin suppresses development of murine systemic vasculitis induced with Candida albicans water-soluble fraction : an animal model of Kawasaki disease. Mod Rheumatol 20 : 160-167, 2010.

15) Oharaseki T, Kameoka Y, Suzuki K, et al : Administration of recombinant single chain fragment of variable region (hScFv) of IGG suppresses development of murine vasculitis induced with Candida albicans water-soluble fraction : An animal model of Kawasaki disease. ADC Letter for Infectious Disease Control 6 : 51-55, 2019.

16) Oharaseki T, Mamada H, Takahashi K, et al : The role of TNF-α in a murine model of Kawasaki disease arteritis induced with a Candida albicans cell wall polysaccharide. Mod Rheumatol 24 : 120-128, 2014.

17) Rosenkranz ME, Schulte DJ, Arditi M : TLR2 and MyD88 contribute to Lactobacillus casei extract-induced focal coronary arteritis in mouse of Kawasaki disease. Circulation 112 : 2966-2973, 2005.

18) Hui-Yuen JS, Duong TT, Yeung RS : TNF-alpha is necessary for induction of coronary inflammation and aneurysm formation in an animal model of Kawasaki disease. J Immunol 176 : 6294-6301, 2006.

19) Lee Y, Schulte DJ, Arditi M, et al : Interleukin-1β is crucial for the induction of coronary artery inflammation in a mouse model of Kawasaki disease. Circulation 125 : 1542-1550, 2012.

20) Motomura Y, Kanno S, Asano K, et al : Identification of pathogenic cardiac CD11c+ macrophages in Nod1-mediated acute coronary arteritis. Arterioscler Thromb Vasc Biol 35 : 1423-1433, 2015.

P.937 掲載の参考文献

1) Naoe S, Takahashi K, Masuda H, et al : Kawasaki disease. With particular emphasis on arterial lesions. Acta Pathol Jpn 41 (11) : 785-797, 1991.

2) Takahashi K, Oharaseki T, Yokouchi Y : Histopathological aspects of cardiovascular lesions in Kawasaki disease. Int J Rheum Dis 21 (1) : 31-35, 2018.

3) Takahashi K, Oharaseki T, Naoe S, et al : Neutrophilic involvement in the damage to coronary arteries in acute stage of Kawasaki disease. Pediatr Int 47 (3) : 305-310, 2005.

4) 増田弘毅, 神田実喜男, 直江史郎, 他 : 川崎病 (MCLS) における冠状動脈瘤と他の冠状動脈瘤との関連性. 脈管学 23 (2) : 135-145, 1983.

5) 濱島義博 : 川崎病. 日本病理学会会誌 66 : 59-92, 1977.

6) Takahashi K, Oharaseki T, Yokouchi Y, et al : A half-century of autopsy results-incidence of pediatric vasculitis syndromes, especially Kawasaki disease. Circ J 76 (4) : 964-970, 2012.

7) 高橋啓, 直江史郎 : 川崎病冠状動脈瘤血栓性閉塞後の再疎通血管における病理組織学的検討. 日本小児循環器学会誌 10 : 223-240, 1994.

8) 浅地聡, 渋谷宏行, 増田弘毅, 他 : 川崎病における腎病変の病理形態学的研究冠状動脈病変との関連を考慮して. 脈管学 29 (6) : 453-460, 1989.

9) Sato W, Yokouchi Y, Oharaseki T, et al : The pathology of Kawasaki disease aortitis : a study of 37 cases. Cardiovasc Pathol 51 : 107303, 2020.

10) 渋谷和俊, 跡部俊彦, 増田弘毅, 他 : 川崎病における肺血管病変の病理組織学的研究. 脈管学 27 (4) : 293-304, 1987.

11) Fujiwara H, Hamashima Y : Pathology of the heart in Kawasaki disease. Periatrics 61 (1) : 100-107, 1978.

12) Amano S, Hazama F, Hamashima Y : Pathology of Kawasaki disease : I Pathology and morphologenesis of the vascular changes. Japanese Circulation J 43 (7) : 633-643, 1979.

13) Harada M, Yokouchi Y, Oharaseki T, et al : Histopathological characteristics of myocarditis in acute-phase Kawasaki disease. Histopathology 61 (6) : 1156-1167, 2012.

14) 菅原敏明 : 小児皮膚疾患に対する免疫病理学的アプローチ川崎病皮膚病変の免疫組織学的検討. 日本小児皮膚科学会雑誌 13 (2) : 107-112, 1994.

15) 渡邊愛子, 藤原碧, 猿喰浩子 : 乾癬様皮疹を呈した川崎病. 皮膚病診療 40 (12) : 1207-1210, 2018.

16) 鈴木祥子, 古賀文二, 今福信一 : 乾癬様の臨床像を呈した川崎病. 皮膚病診療 39 (5) : 507-510, 2017.

17) Yokouchi Y, Oharaseki T, Harada M, et al : Histopathological study of lymph node lesions in the acute phase of Kawasaki disease. Histopathology 62 (3) : 387-396, 2013.

P.944 掲載の参考文献

1) 日本川崎病学会, 特定非営利活動法人日本川崎病研究センター, 厚生労働科学研究難治性血管炎に関する調査研究班 : 川崎病診断の手引き改訂第6版. http://www.jskd.jp/info/pdf/tebiki201906.pdf (2021年6月12日アクセス)

2) 柳川洋 : 川崎病の実態. 公衆衛生情報 5 (12) 別冊 : 22-29, 1975. https://www.jichi.ac.jp/dph/kawasakibyou/report/report1-3.pdf (2021年6月12日アクセス)

3) Newburger JW, Takahashi M, Beiser AS, et al : A single intravenous infusion of gamma globulin as compared with four infusions in the treatment of acute Kawasaki syndrome. N Engl J Med 324 (23) : 1633-1639, 1991.

4) 特定非営利活動法人日本川崎病研究センター, 川崎病全国調査担当グループ : 第25回川崎病全国調査成績 (2021年6月12日アクセス)

5) 日本循環器学会/日本心臓血管外科学会合同ガイドライン : 2020年改訂版川崎病心臓血管後遺症の診断と治療に関するガイドライン, 2020.

6) Kondo E, Tanaka T, Nakano T, et al : Cellulitis caused by Streptococcus pyogenes at the Bacille Calmette-Guerin vaccination site : A case report. Kawasaki Medical Journal 44 (1) : 27-31, 2018.

7) Kakisaka Y, Ohara T, Katayama S, et al : Human Herpes Virus Type 6 Can Cause Skin Lesions at the BCG Inoculation Site Similar to Kawasaki Disease. Tohoku J Exp Med 228 (4) : 351-353, 2012.

8) Lai CC, Lee PC, Wang CC, et al : Reaction at the Bacillus-Calmette-Guerin inoculation site in patients with Kawasaki disease. Pediatr Neonatol 54 (1) : 43-48, 2013.

9) Lin MT, Wang JK, Yeh JI, et al : Clinical Implication of the C Allele of the ITPKC Gene SNP rs28493229 in Kawasaki Disease : Association With Disease Susceptibility and BCG Scar Reactivation. Pediatr Infect Dis J 30 (2) : 148-152, 2011.

10) Garrido-Garcia LM, Moguel AC, Rivera MV, et al : Reaction of the BCG Scar in the Acute Phase of Kawasaki Disease in Mexican Children. Pediatr Infect Dis J 36 (10) : e237-e241, 2017.

11) Diniz LMO, Castanheira RG, Giampietro YG, et al : Diagnostic value of the reaction at the Bacillus Calmette- Guerin vaccination site in Kawasaki Disease. Rev Paul Pediatr 39 : e2019338, 2021.

12) 福田清香, 今野裕章, 松本峻, 他 : 川崎病診断の手引き改訂 (第6版) が診断に及ぼす影響. 日本小児科学会雑誌 124 (10) : 1484-1489, 2020.

13) McCrindle BW, Rowley AH, Newburger JW, et al : Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease : A Scientific Statement for Health Professionals from the American Heart Association. Circulation 135 (17) : e927-e999, 2017.

14) Dionne A, Meloche-Dumas L, Desjardins L, et al : N-terminal pro-B-type natriuretic peptide diagnostic algorithm versus American Heart Association algorithm for Kawasaki disease. Pediatr Int 59 (3) : 265-270, 2017.

15) Diagnostic Radiology : Pediatric Radiology Normal Measurements. https://www.ohsu.edu/schoolof-medicine/diagnostic-radiology/pediatricradiology-normal-measurements#section-124751

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17) Kanegaye JT, Van Cott E, Tremoulet AH, et al : Lymph-node-first presentation of Kawasaki disease compared with bacterial cervical adenitis and typical Kawasaki disease. J Pediatr 162 (6) : 1259-1263, 1263.e1-2, 2013.

18) Yanagi S, Nomura Y, Masuda K, et al : Early diagnosis of Kawasaki disease in patients with cervical lymphadenopathy. Pediatr Int 50 (2) : 179-183, 2008.

19) 日本川崎病学会編 : 川崎病診断の手引きガイドブック 2020, 診断と治療社, 東京, 2020.

P.952 掲載の参考文献

1) 佐地勉, 薗部友良, 上村茂, 他 : 川崎病急性期治療のガイドライン. 日本小児循環器学会雑誌 20 (1) : 54-62, 2003

2) Kobayashi T, Inoue Y, Takeuchi K, et al : Prediction of intravenous immunoglobulin unresponsiveness in patients with Kawasaki disease. Circulation 113 (22) : 2606-2612, 2006.

3) Egami K, Muta H, Ishii M, et al : Prediction of resistance to intravenous immunoglobulin treatment in patients with Kawasaki disease. J Pediatr 149 (2) : 237-240, 2006.

4) Sano T, Kurotobi S, Matsuzaki K, et al : Prediction of non-responsiveness to standard high-dose gamma-globulin therapy in patients with acute Kawasaki disease before starting initial treatment. Eur J Pediatr 166 (2) : 131-137, 2007.

5) Kobayashi T, Saji T, Otani T, et al : Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study) : a randomised, open-label, blinded-endpoints trial. Lancet 379 (9826) : 1613-1620, 2012.

6) Ogata S, Ogihara Y, Honda T, et al : Corticosteroid pulse combination therapy for refractory Kawasaki disease : A randomized trial. Pediatrics 129 (1) : e17-e23, 2012.

7) 佐地勉, 鮎澤衛, 三浦大, 他 : 川崎病急性期治療のガイドライン (平成24年改訂版). 日本小児循環器学会雑誌 28 (s3) : s1-s28, 2012.

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9) Miyata K, Kaneko T, Morikawa Y, et al : Efficacy and safety of intravenous immunoglobulin plus prednisolone therapy in patients with Kawasaki disease (Post RAISE) : a multicentre, prospective cohort study. Lancet Child Adolesc Health 2 (12) : 855-862, 2018.

10) Mori M, Hara T, Kikuchi M, et al : Infliximab versus intravenous immunoglobulin for refractory Kawasaki disease : a phase 3, randomized, open-label, active-controlled, parallel-group, multicenter trial. Sci Rep 8 (1) : 1994, 2018.

11) Tremoulet AH, Jain S, Jaggi P, et al : Infliximab for intensification of primary therapy for Kawasaki disease : a phase 3 randomised, double-blind, placebo-controlled trial. Lancet 383 (9930) : 1731-1738, 2014.

12) Hamada H, Suzuki H, Onouchi Y, et al : Efficacy of primary treatment with immunoglobulin plus ciclosporin for prevention of coronary artery abnormalities in patients with Kawasaki disease predicted to be at increased risk of non-response to intravenous immunoglobulin (KAICA) : a randomised controlled, open-label, blinded-endpoints, phase 3 trial. Lancet 393 (10176) : 1128-1137, 2019.

13) 三浦大, 鮎澤衛, 伊藤秀一, 他 : 川崎病急性期治療のガイドライン (2020年改訂版). 日本小児循環器学会雑誌 36 (s1) : s1.1-s1.29, 2020.

14) Miura M, Kobayashi T, Igarashi T, et al : Realworld safety and effectiveness of infliximab in pediatric patients with acute Kawasaki disease : a post-marketing surveillance in Japan (SAKURA Study). Pediatr Infect Dis J 39 (1) : 41-47, 2020.

15) Gamez-Gonzalez LB, Moribe-Quintero I, Cisneros-Castolo M, et al : Kawasaki disease shock syndrome : unique and severe subtype of Kawasaki disease. Pediatr Int 60 (9) : 781-790, 2018.

16) Hoste L, Paemel RV, Haerynck F, et al : Multisystem inflammatory syndrome in children related to COVID-19 : a systematic review. Eur J Pediatr 2021 (in press).

17) Baba T, Maruyama T, Katsuragi S, et al : Multi-system inflammatory syndrome associated with SARS-CoV-2 in a Japanese girl. Pediatr Int 2021 (in press).

18) McCrindle BW, Rowley AH, Newburger JW, et al : Diagnosis, treatment, and long-term management of Kawasaki disease ; a scientific statement for health professionals from the American Heart Association. Circulation 135 (17) : e927-e999, 2017.

19) de Graeff N, Groot N, Ozen S, et al : European consensus-based recommendations for the diagnosis and treatment of Kawasaki disease-the SHARE initiative. Rheumatology 58 (4) : 672-682, 2019.

20) 細川静雄, 原信田実 : 川崎病は, いま-聞き書き川崎富作. 木魂社, 東京, 2006.

P.960 掲載の参考文献

1) 日本循環器学会, 他学術委員会合同研究班 : 2020年改訂版川崎病心臓血管後遺症の診断と治療に関するガイドライン. https://wwwj-circorjp/cms/wp-content/uploads/2020/02/JCS2020_Fukazawa_Kobayashipdf (2021年5月21日アクセス)

2) Kato H, Sugimura T, Akagi T, et al : Long-term Consequences of Kawasaki Disease : A 10- to 21-Year Follow-up Study of 594 Patients. Circulation 94 : 1379-1385, 1996.

3) Miura M, Kobayashi T, Kaneko T, et al : Association of Severity of Coronary Artery Aneurysms in Patients With Kawasaki Disease and Risk of Later Coronary Events. JAMA Pediatr 172 : e180030, 2018.

4) Suzuki A, Miyagawa-Tomita S, Komatsu K, et al : Active remodeling of the coronary arterial lesions in the late phase of Kawasaki disease : immunohistochemical study. Circulation 101 : 2935-2941, 2000.

5) Fukazawa R, Ikegam E, Watanabe M, et al : Coronary artery aneurysm induced by Kawasaki disease in children show features typical senescence. Circ J 71 : 709-715, 2007.

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【Diagnosis】

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7) Wes(TM) (ウエス) 製品カタログ (プロテインシンプルジャパン株式会社).

【Health Care】

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