1) 国立研究開発法人国立がん研究センターがん対策情報センター : がん登録・統計. http://ganjoho.jp/reg_stat/statistics/index.html
2) 日本膵臓学会膵癌診療ガイドライン改訂委員会 編 : 膵癌診療ガイドライン 2019年版, 金原出版, 東京, 2019.
3) Neoptolemos JP, Stocken DD, Friess H, et al : A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N Engl J Med 350 (12) : 1200-1210, 2004.
4) Oettle H, Neuhaus P, Hochhaus A, et al : Adjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer : the CONKO-001 randomized trial. JAMA 310 (14) : 1473-1481, 2013.
5) Uesaka K, Boku N, Fukutomi A, et al : Adjuvant chemotherapy of S-1 versus gemcitabine for resected pancreatic cancer : a phase 3, open-label, randomised, non-inferiority trial (JASPAC 01). Lancet 388 (10041) : 248-257, 2016.
6) Neoptolemos JP, Palmer DH, Ghaneh P, et al : Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4) : a multicentre, open-label, randomised, phase 3 trial. Lancet 389 (10073) : 1011-1024, 2017.
7) Conroy T, Hammel P, Hebbar M, et al : FOLFIRINOX or gemcitabine as adjuvant therapy for pancreatic cancer. N Engl J Med 379 (25) : 2395-2406, 2018.
8) Tempero MA, Reni M, Riess H, et al : APACT : Phase III, multicenter, international, open-label, randomized trial of adjuvant nab-paclitaxel plus gemcitabine (nab-P/G) vs gemcitabine (G) for surgically resected pancreatic adenocarcinoma. J Clin Oncol 37 (suppl) : abstr 4000, 2019.
9) Satoi S, Unno M, Motoi F, et al : The effect of neoadjuvant chemotherapy with gemcitabine and S-1 for resectable pancreatic cancer (randomized phase II/III trial ; Prep-02/JSAP-05). J Clin Oncol 37 (suppl) : abstr 4126, 2019.
10) Moertel CG, Childs DS, Jr., Reitemeier RJ, et al : Combined 5-fluorouracil and supervoltage radiation therapy of locally unresectable gastrointestinal cancer. Lancet 2 (7626) : 865-867, 1969.
11) Moertel CG, Frytak S, Hahn RG, et al : Therapy of locally unresectable pancreatic carcinoma : a randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads+5-fluorouracil), and high dose radiation+5-fluorouracil : The Gastrointestinal Tumor Study Group. Cancer 48 (8) : 1705-1710, 1981.
12) Cohen SJ, Dobelbower R, Jr., Lipsitz S, et al : A randomized phase III study of radiotherapy alone or with 5-fluorouracil and mitomycin-C in patients with locally advanced adenocarcinoma of the pancreas : Eastern Cooperative Oncology Group study E8282. Int J Radiat Oncol Biol Phys 62 (5) : 1345-1350, 2005.
13) Klaassen DJ, MacIntyre JM, Catton GE, et al : Treatment of locally unresectable cancer of the stomach and pancreas : a randomized comparison of 5-fluorouracil alone with radiation plus concurrent and maintenance 5-fluorouracil-an Eastern Cooperative Oncology Group study. J Clin Oncol 3 (3) : 373-378, 1985.
14) Gastrointestinal Tumor Study Group : Treatment of locally unresectable carcinoma of the pancreas : comparison of combined-modality therapy (chemotherapy plus radiotherapy) to chemotherapy alone. Gastrointestinal Tumor Study Group. J Natl Cancer Inst 80 (10) : 751-755, 1988.
15) Ishii H, Furuse J, Boku N, et al : Phase II study of gemcitabine chemotherapy alone for locally advanced pancreatic carcinoma : JCOG0506. Jpn J Clin Oncol 40 (6) : 573-579, 2010.
16) Chauffert B, Mornex F, Bonnetain F, et al : Phase III trial comparing intensive induction chemoradiotherapy (60 Gy, infusional 5-FU and intermittent cisplatin) followed by maintenance gemcitabine with gemcitabine alone for locally advanced unresectable pancreatic cancer. Definitive results of the 2000-01 FFCD/SFRO study. Ann Oncol 19 (9) : 1592-1599, 2008.
17) Loehrer PJ, Sr., Feng Y, Cardenes H, et al : Gemcitabine alone versus gemcitabine plus radiotherapy in patients with locally advanced pancreatic cancer : an Eastern Cooperative Oncology Group trial. J Clin Oncol 29 (31) : 4105-4112, 2011.
18) Mukherjee S, Hurt CN, Bridgewater J, et al : Gemcitabine-based or capecitabine-based chemoradiotherapy for locally advanced pancreatic cancer (SCALOP) : a multicentre, randomised, phase 2 trial. Lancet Oncol 14 (4) : 317-326, 2013.
19) Hammel P, Huguet F, van Laethem JL, et al : Effect of chemoradiotherapy vs chemotherapy on survival in patients with locally advanced pancreatic cancer controlled after 4 months of gemcitabine with or without erlotinib : the LAP07 randomized clinical trial. JAMA 315 (17) : 1844-1853, 2016.
20) Ioka T, Furuse J, Fukutomi A, et al : Randomized phase II study of chemoradiotherapy with versus without induction chemotherapy for locally advanced pancreatic cancer : Japan Clinical Oncology Group trial, JCOG1106. Jpn J Clin Oncol 51 (2) : 235-243, 2021.
21) Conroy T, Desseigne F, Ychou M, et al : FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med 364 (19) : 1817-1825, 2011.
22) Von Hoff DD, Ervin T, Arena FP, et al : Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med 369 (18) : 1691-1703, 2013.
23) Suker M, Beumer BR, Sadot E, et al : FOLFIRINOX for locally advanced pancreatic cancer : a systematic review and patient-level meta-analysis. Lancet Oncol 17 (6) : 801-810, 2016.
24) Philip PA, Lacy J, Portales F, et al : Nab-paclitaxel plus gemcitabine in patients with locally advanced pancreatic cancer (LAPACT) : a multicentre, open-label phase 2 study. Lancet Gastroenterol Hepatol 5 (3) : 285-294, 2020.
25) Ozaka M, Ueno M, Ishii H, et al : Randomized phase II study of modified FOLFIRINOX versus gemcitabine plus nab-paclitaxel combination therapy for locally advanced pancreatic cancer (JCOG1407). 2021 ASCO Annual Meeting. J Clin Oncol 39 (suppl 15) : abstr 4017, 2021.
26) Burris HA 3rd, Moore MJ, Andersen J, et al : Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer : a randomized trial. J Clin Oncol 15 (6) : 2403-2413, 1997.
27) Moore MJ, Goldstein D, Hamm J, et al : Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer : a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 25 (15) : 1960-1966, 2007.
28) Ueno H, Ioka T, Ikeda M, et al : Randomized Phase III Study of Gemcitabine Plus S-1, S-1 Alone, or Gemcitabine Alone in Patients With Locally Advanced and Metastatic Pancreatic Cancer in Japan and Taiwan : GEST Study. J Clin Oncol 31 (13) : 1640-1648, 2013.
29) Okusaka T, Ikeda M, Fukutomi A, et al : Phase II study of FOLFIRINOX for metastatic chemotherapy-naive Japanese pancreatic cancer patients. Cancer Sci 105 (10) : 1321-1326, 2014.
30) Ueno H, Ikeda M, Ueno M, et al : Phase I/II study of nab-paclitaxel plus gemcitabine for chemotherapy-naive Japanese patients with metastatic pancreatic cancer. Cancer Chemother Pharmacol 77 (3) : 595-603, 2016.
31) Ozaka M, Ishii H, Sato T, et al : A phase II study of modified FOLFIRINOX for chemotherapy-naive patients with metastatic pancreatic cancer. Cancer Chemother Pharmacol 81 (6) : 1017-1023, 2018.
32) Pelzer U, Schwaner I, Stieler J, et al : Best supportive care (BSC) versus oxaliplatin, folinic acid and 5-fluorouracil (OFF) plus BSC in patients for second-line advanced pancreatic cancer : a phase III-study from the German CONKO-study group. Eur J Cancer 47 (11) : 1676-1681, 2011.
33) Oettle H, Riess H, Stieler JM, et al : Second-line oxaliplatin, folinic acid, and fluorouracil versus folinic acid and fluorouracil alone for gemcitabine-refractory pancreatic cancer : outcomes from the CONKO-003 trial. J Clin Oncol 32 (23) : 2423-2429, 2014.
34) Gill S, Ko YJ, Cripps C, et al : PANCREOX : A Randomized Phase III Study of Fluorouracil/Leucovorin With or Without Oxaliplatin for Second-Line Advanced Pancreatic Cancer in Patients Who Have Received Gemcitabine-Based Chemotherapy. J Clin Oncol 34 (32) : 3914-3920, 2016.
35) Wang-Gillam A, Li CP, Bodoky G, et al : Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1) : a global, randomised, open-label, phase 3 trial. Lancet 387 (10018) : 545-557, 2016.
36) Ohkawa S, Okusaka T, Isayama H, et al : Randomised phase II trial of S-1 plus oxaliplatin vs S-1 in patients with gemcitabine-refractory pancreatic cancer. Br J Cancer 112 (9) : 1428-1434, 2015.
37) Ioka T, Komatsu Y, Mizuno N, et al : Randomised phase II trial of irinotecan plus S-1 in patients with gemcitabine-refractory pancreatic cancer. Br J Cancer 116 (4) : 464-471, 2017.
38) Ioka T, Ueno M, Ueno H, et al : TAS-118 (S-1 plus leucovorin) versus S-1 in patients with gemcitabine-refractory advanced pancreatic cancer : a randomised, open-label, phase 3 study (GRAPE trial). Eur J Cancer 106 : 78-88, 2019.
39) Ueno M, Nakamori S, Sugimori K, et al : nal-IRI+5-FU/LV versus 5-FU/LV in post-gemcitabine metastatic pancreatic cancer : Randomized phase 2 trial in Japanese patients. Cancer Med 9 (24) : 9396-9408, 2020.
40) Le DT, Durham JN, Smith KN, et al : Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade. Science 357 (6349) : 409-413, 2017.
41) Marabelle A, Le DT, Ascierto PA, et al : Efficacy of pembrolizumab in patients with noncolorectal high microsatellite instability/mismatch repair-deficient cancer : results from the phase II KEYNOTE-158 Study. J Clin Oncol 38 (1) : 1-10, 2020.
42) Doebele RC, Drilon A, Paz-Ares L, et al : Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours : integrated analysis of three phase 1-2 trials. Lancet Oncol 21 (2) : 271-282, 2020.
43) Laetsch TW, DuBois SG, Mascarenhas L, et al : Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions : phase 1 results from a multicentre, open-label, phase 1/2 study. Lancet Oncol 19 (5) : 705-714, 2018.
44) Golan T, Hammel P, Reni M, et al : Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer. N Engl J Med 381 (4) : 317-327, 2019.