成分栄養剤のこれまでとこれから エビデンスからの期待

出版社: 先端医学社
著者:
発行日: 2023-01-31
分野: 臨床医学:一般  >  栄養/食事/輸血
ISBN: 9784865505832
電子書籍版: 2023-01-31 (第1版第1刷)
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商品紹介

わが国で開発・製品化され、発展を遂げた成分栄養剤(エレンタール®配合内用剤)は今や消化器疾患の治療において非常に重要な選択肢となっている。本書では成分栄養剤を用いた栄養管理・栄養療法について、周術期・IBD・がん治療の支持療法・膵疾患の4つの分野でこれまでに蓄積された豊富なエビデンスを詳細に解説している。臨床栄養に携わる医療スタッフにとって必読の一冊。

目次

  • PART 1 序章
     わが国における成分栄養剤の開発の経緯と軌跡・今後の展望
     
    PART 2 周術期における成分栄養剤のこれまでとこれから
     1.周術期における成分栄養剤の位置づけと役割
     2.侵襲時のアミノ酸代謝
     3.術後回復促進プログラム(ERAS)における成分栄養剤の役割
     4.膵頭十二指腸切除術の栄養管理と成分栄養療法
     5.食道がん術後早期経腸栄養:成分栄養剤を用いた乳び胸発症予防
     6.胃瘻栄養時の成分栄養剤の胃排出速度

    PART 3 IBDにおける成分栄養剤のこれまでとこれから
     1.IBDにおける成分栄養剤の歴史と役割
     2.IBDの治療における成分栄養剤の位置づけ
     3.生物学的製剤時代における成分栄養療法の位置づけ
     4.小児IBD治療における成分栄養療法
     5.IBDの外科治療における成分栄養療法の役割
     6.IBD治療における成分栄養療法のアドヒアランス向上の意義と実際(エビデンスの視点も交え)
     7.IBDの病態と成分栄養剤の機能 IBDにおける栄養素と成分栄養剤の機能
       ~エネルギー,タンパク質,脂肪の影響~
     8.IBDにおける腸内細菌叢のかかわりと成分栄養剤の役割

    Part 4 がん支持療法における成分栄養剤のこれまでとこれから
     1.がん支持療法における成分栄養剤の位置づけと役割
     2.胃がんの外科的治療における成分栄養剤の役割
      (1) 胃切除後の成分栄養剤による早期介入(KSES001・002試験)
      (2) 胃がん術後化学療法における成分栄養剤の併用療法(OGSG1108)
     3.食道がんの化学療法における成分栄養剤の実際
     4.口腔がん治療における成分栄養剤の実際

    Part 5 膵疾患における成分栄養剤のこれまでとこれから
     1.膵疾患における成分栄養剤の位置づけと役割
     2.成分栄養剤のコレシストキニン(CCK)分泌に及ぼす影響
     3.膵炎における成分栄養剤の実際
     4.膵がんにおける成分栄養剤の実際

この書籍の参考文献

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本参考文献は電子書籍掲載内容を元にしております。

Part 1 序章

P.18 掲載の参考文献
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14) 永井鑑. 五関謹秀, 井上晴洋ほか : 汚染経腸栄養剤に起因すると推測されたE. cloacae敗血症の2例. 外科と代謝・栄養 31 : 315-320, 1997
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Part 2 周術期における成分栄養剤のこれまでとこれから

P.25 掲載の参考文献
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2) 小越章平, 佐藤博 : EDの特性と適応. 臨床外科 34 : 457-462, 1979
3) 鍋谷圭宏, 大村健二 : combined nutritional therapy. 外科と代謝・栄養 52 : 191-194, 2018
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4) Weimann A, Braga M, Carli F et al : ESPEN practical guideline : clinical nutrition in surgery. Clin Nutr 40 : 4745-4761, 2021
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P.45 掲載の参考文献
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P.50 掲載の参考文献
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2) Horiuchi A, Sakai R, Tamaki M et al : Gastric Emptying of Elemental Liquid Diets Versus Semisolid Diets in Bedridden Gastrostomy-fed Patients. J Clin Gastroenterol 53 : 373-378, 2019

Part 3 IBDにおける成分栄養剤のこれまでとこれから

P.55 掲載の参考文献
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18) Nguyen DL, Palmer LB, Nguyen ET et al : Specialized enteral nutrition therapy in Crohn's disease patients on maintenance infliximab therapy : a meta-analysis. Therap Adv Gastroenterol 8 : 168-175, 2015
19) Hirai F, Takeda T, Takada Y et al : Efficacy of enteral nutrition in patients with Crohn's disease on maintenance anti-TNF-α antibody therapy : a meta-analysis. J Gastroenterol 55 : 133-141, 2020
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P.64 掲載の参考文献
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P.71 掲載の参考文献
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P.76 掲載の参考文献
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13) Fujimoto T, Imaeda H, Takahashi K et al : Decreased abundance of Faecalibacterium prausnitzii in the gut microbiota of Crohn's disease. J Gastroenterol Hepatol 28 : 613-619, 2013
14) Takahashi K, Nishida A, Fujimoto T et al : Reduced abundance of butyrate-producing bacteria species in the fecal microbial community in Crohn's disease. Digestion 93 : 59-65, 2016
15) Vester-Andersen MK, Mirsepasi-Lauridscn HC, Prosberg MV et al : Increased abundance of proteobacteria in aggressive Crohn's disease seven years after diagnosis. Sci Rep 9 : 13473, 2019
16) Peterson DA, Frank DN, Pace NR et al : Metagenomic approaches for defining the pathogenesis of inflammatory bowel diseases. Cell Host Microbe 3 : 417-427, 2008
17) Palmela C, Chevarin C, Xu Z et al : Adherent-invasive Escherichia coli in inflammatory bowel dlsease. Gut 67 : 574-587, 2018
18) Chervy M, Barnich N, Denizot J : Adherent-Invasive E. coli : update on the lifestyle of a troublemaker in Crohn's disease. Int J Mol Sci 21 : 3734, 2020
19) Takagi S. Utsunomiya K, Kuriyama S et al : Effectiveness of an 'half elemental diet' as maintenance therapy for Crohn's disease : a randomized-controlled trial. Aliment Pharmacol Ther 24 : 1333-1340, 2006
20) Okada M, Yao T, Yamamoto T et al : Controlled trial comparing an elemental diet with prednisolone in the treatment of active Crohn's disease. Hepatogastroenterology 37 : 72-80, 1990
21) Hirai F, Ishida T, Takeshima F et al : Effect of a concomitant elemental diet with maintenance anti-tumor necrosis factor-α antibody therapy in patients with Crohn's disease : a multicenter, prospective cohort study. J Gastroenterol Hepatol 34 : 132-139, 2019
22) Andou A, Hisamatsu T, Okamoto S et al : Dietary histidine ameliorates murine colitis by inhibition of proinflammatory cytokine production from macrophages. Gastroenterology 136 : 564-574.e562, 2009
23) Ameho CK, Adjei AA, Harrison EK et al : Prophylactic effect of dietary glutamine supplementation on interleukin 8 and tumour necrosis factor alpha production in trinitrobenzene sulphonic acid induced colitis. Gut 41 : 487-493, 1997
24) Coburn LA, Gong X, Singh K et al : L-arginine supplementation improves responses to injury and inflammation in dextran sulfate sodium colitis. PLoS One 7 : e33546, 2012
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27) Liu X, Beaumont M, Walker F et al : Beneficial effects of an amino acid mixture on colonic mucosal healing in rats. Inflamm Bowel Dis 19 : 2895-2905, 2013
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30) Xue H, Sufit AJD, Wischmeyer PE : Glutamine therapy improves outcome of in vitro and in vivo experimental colitis models. JPEN J Parenter Enteral Nutr 35 : 188-197, 2011
31) Miyoshi J, Saito D, Nakamura M et al : Half-elemental diet shifts the human intestinal bacterial compositions and metabolites : a pilot study with healthy individuals. Gastroenterol Res Pract 2020 : 7086939, 2020
32) Andoh A, Inoue R, Kawada Y et al : Elemental diet induces alterations of the gut microbial community in mice. J Clin Biochem Nutr 65 : 118-124, 2019

Part 4 がん支持療法における成分栄養剤のこれまでとこれから

P.106 掲載の参考文献
1) Japanese Gastric Cancer Association : Japanese gastric cancer treatment guidelines 2014 (ver. 4). Gastric Cancer 20 : 1-19, 2017
2) Sakuramoto S, Sasako M, Yamaguchi T et al : Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine. N Engl J Med 357 : 1810-1820, 2007
3) Aoyama T, Yoshikawa T, Shirai J et al : Body weight loss after surgery is an independent risk factor for continuation of S-1 adjuvant chemotherapy for gastric cancer. Ann Surg Oncol 20 : 2000-2006, 2013
4) Aoyama T, Sato T, Maezawa Y et al : Postoperative weight loss leads to poor survival through poor S-1 efficacy in patients with stage II/III gastric cancer. Int J Clin Oncol 22 : 476-483, 2017
5) Aoyama T, Kawabe T, Fujikawa H et al : Loss of lean body mass as an independent risk factor for continuation of S-1 adjuvant chemotherapy for gastric cancer. Ann Surg Oncol 22 : 2560-2566, 2015
6) Aoyama T, Yoshikawa T, Maezawa Y et al : The postoperative lean body mass loss at one month leads to a poor survival in patients with locally advanced gastric cancer. J Cancer 10 : 2450-2456, 2019
7) Koterazawa Y, Oshikiri T, Takiguchi G et al : Severe weight loss after minimally invasive oesophagectomy is associated with poor survival in patients with oesophageal cancer at 5 years. BMC Gastroenterol 20 : 407, 2020
8) Mayanagi S, Tsubosa Y, Omae K et al : Negative impact of skeletal muscle wasting after neoadjuvant chemotherapy followed by surgery on survival for patients with thoracic esophageal cancer. Ann Surg Oncol 24 : 3741-3747, 2017
9) Ida S, Hiki N, Cho H et al : Randomized clinical trial comparing standard diet with perioperative oral immunonutrition in total gastrectomy for gastric cancer. Br J Surg 104 : 377-383, 2017
10) Imamura H, Nishikawa K, Kishi K et al : Effects of an oral elemental nutritional supplement on post-gastrectomy body weight loss in gastric cancer patients : a randomized controlled clinical trial. Ann Surg Oncol 23 : 2928-2935, 2016
11) Kimura Y, Nishikawa K, Kishi K et al : Long-term effects of an oral elemental nutritional supplement on post-gastrectomy body weight loss in gastric cancer patients (KSES002). Ann Gastroenterol Surg 3 : 648-656, 2019
12) Qiu M, Zhou YX, Jin Y et al : Nutrition support can bring survival benefit to high nutrition risk gastric cancer patients who received chemotherapy. Support Care Cancer 23 : 1933-1939, 2015
13) Bozzetti F : Does nutrition support during chemotherapy increase long-term survival of cancer patients? Lessons from the past and future perspectives. Support Care Cancer 29 : 7269-7277, 2021
14) Lalla RV, Bowen J, Barasch A et al : MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer 120 : 1453-1461, 2014
15) Tanaka Y, Shimokawa T, Harada K et al : Effectiveness of elemental diets to prevent oral mucositis associated with cancer therapy : A meta-analysis. Clin Nutr ESPEN 49 : 172-180, 2022
P.111 掲載の参考文献
1) Aoyama T, Yoshikawa T, Shirai J et al : Body weight loss after surgery is an independent risk factor for continuation of S-1 adjuvant chemotherapy for gastric cancer. Ann Surg Oncol 20 : 2000-2006, 2013
2) Aoyama T, Sato T, Maezawa Y et al : Postoperative weight loss leads to poor survival through poor S-1 efficacy in Patients with stage II/III gastric cancer. Int J Clin Oncol 22 : 476-483, 2017
3) Lee HH, Park JM, Song KY et al : Survival impact of postoperative body mass index in gastric cancer patients undergoing gastrectomy. Eur J Cancer 52 : 129. -137, 2016
4) Imamura H, Nishikawa K, Kishi K et al : Effects of an oral elemental nutritional supplement on post-gastrectomy body weight loss in gastric cancer patients : a randomized controlled clinical trial. Ann Surg Oncol 23 : 2928-2935, 2016
5) Kimura Y, Nishikawa K, Kishi K et al : Long-term effects of an oral elemental nutritional supplement on post-gastrectomy body weight loss in gastric cancer patients (KSES002). Ann Gastroenterol Surg 3 : 648-656, 2019
6) 吉川貴己, 青山徹, 林勉ほか : 胃癌術後の体重/体組成変動とその意義. 外科と代謝・栄養 49 : 205-211, 2015
7) 中田浩二 : 胃切除後障害の今日的話題. 日本臨床外科学会雑誌 77 : 1007-1022, 2016
9) Aoyama T, Kawabe T, Fujikawa H et al : Loss of lean body mass as an independent risk factor for continuation of S-1 adjuvant chemotherapy for gastric cancer. Ann Surg Oncol 22 : 2560-2566, 2015
11) Ida S, Hiki N, Cho H et al : Randomized clinical trial comparing standard diet with perioperative oral immunonutrition in total gastrectomy for gastric cancer. Br J Surg 104 : 377-383, 2017
P.116 掲載の参考文献
1) 胃癌治療ガイドライン 医師用 2021年7月改訂 第6版, 日本胃癌学会, 金原出版, 東京, 2021
4) Aoyama T, Yoshikawa T, Shirai J et al : Body weight loss after surgery is an independent risk factor for continuation of S-1 adjuvant chemotherapy for gastric cancer. Ann Surg Oncol 20 : 2000-2006, 2013
5) Aoyama T, Sato T, Maezawa Y et al : Postoperative weight loss leads to poor survival through poor S-1 efficacy in patients with stage II/III gastric cancer. Int J Clin Oncol 22 : 476-483, 2017
6) Imamura H, Nishikawa K, Kishi K et al : Effects of an oral elemental nutritional supplement on post-gastrectomy body weight loss in gastric cancer patients : a randomized controlled clinical trial. Ann Surg Oncol 23 : 2928-2935, 2016
8) Sakuramoto S, Sasako M, Yamaguchi T et al : Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine. N Engl J Med 357 : 1810-1820, 2007
9) Taiho Pharmaceutical Co., Ltd. Study report. No. 717, 2017
P.121 掲載の参考文献
2) 静脈経腸栄養ガイドライン 第3版, 日本静脈経腸栄養学会, 照林社, 東京, 2013
11) Tanaka Y, Yoshida K, Osada S et al : Docetaxel, nedaplatin, and S-1 (DGS) chemotherapy for advanced esophageal carcinoma : a phase I dose-escalation study. Anticancer Res 31 : 4589-4597, 2011
15) 小山諭, 田中善宏, 田原信ほか : がん化学療法の完遂を目指して-新しい支持療法の概念と実践-. Pharma Medica 29 : 201-208, 2011
21) Tanaka Y, Shimokawa T, Harada K et al : Effectiveness of elemental diets to prevent oral mucositis associated with cancer therapy : A meta-analysis. Clin Nutr ESPEN 49 : 172-180, 2022
P.128 掲載の参考文献

Part 5 膵疾患における成分栄養剤のこれまでとこれから

P.136 掲載の参考文献
1) 片岡慶正, 阪上順一, 泰井敦子ほか : 疼痛を有する慢性膵炎治療に成分栄養剤 (ED) は有効か. 難治性膵疾患に関する調査研究 平成19年度総括・分担研究報告書 : 222-226, 2008
2) Ito T, Igarashi H, Niina Y et al : Management of pain in chronic pancreatitis with home elemental diet ingestion. JOP 11 : 648-649, 2010
4) 慢性膵炎診療ガイドライン2015 改訂第2版, 日本消化器病学会編, 南江堂, 東京, 2015, pp. 61-62
5) 慢性膵炎診療ガイドライン 2021 改訂第3版, 日本消化器病学会編, 南江堂, 東京, 2021. pp. 71-72
P.141 掲載の参考文献
15) 塩賀太郎, 高山敬子, 田原純子ほか : 重症急性膵炎に対する経鼻胃管チューブ下早中期経腸栄養療法の有用性. 膵臓 32 : 806-811, 2017
P.146 掲載の参考文献
1) Sommer H, Kasper H : Effect of the nitrogen components of a peptide diet and the analogous amino acids on pancreatic secretion in the human. Z Gastroenterol 20 : 681-687, 1982
3) 急性膵炎診療ガイドライン 2021 第5版, 急性膵炎診療ガイドライン 2021 改訂出版委員会, 金原出版, 東京, 2021
4) 静脈経腸栄養ガイドライン 第3版, 日本静脈経腸栄養学会, 照林社, 東京, 2013
9) 阪上順一 : 急性膵炎・重症急性膵炎. 今日の治療指針 2023年版, in press, 2023
15) 栗山とよ子 : 膵疾患の栄養管理. 静脈経腸栄養 26 : 713-722, 2011
16) Bruno MJ, Haverkort EB, Tytgat GN et al : Maldigestion associated with exocrine pancreatic insufficiency : implications of gastrointestinal physiology and properties of enzyme preparations for a cause-related and patient-tailored treatment. Am J Gastroenterol 90 : 1383-1393, 1995
18) 阪上順一 : 慢性膵炎における栄養管理. 臨床栄養 136 : 601-606, 2020
20) 慢性膵炎診療ガイ ドライン 2021 改訂第3版, 日本消化器病学会, 南江堂, 東京, 2021
21) 片岡慶正, 阪上順一, 保田宏明ほか : 難治性膵疾患に関する調査研究 慢性膵炎疼痛対策としての経腸栄養療法の検証と標準化. 難治性膵疾患に関する調査研究平成27年度 総括・分担研究報告書 (厚生労働科学研究費補助金難治性疾患等政策研究事業 (難治性疾患政策研究事業)) : 202-209, 2016
22) Kawaguchi Y, Lin JC, Kawashima Y et al : Relationship between pain and plasma amino acid levels in chronic pancreatitis. JOP 16 : 53-57, 2015
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4) 中村陽介, 廣岡芳樹, 伊藤彰浩ほか : 切除不能進行膵癌例に対する栄養療法の有用性. 膵臓 27 : 649-655, 2012
5) 畔元信明, 熊木天児, 黒田太良ほか : 当科で経過をおえた膵癌stage IVb死亡症例における予後因子の検討. 愛媛医学 32 : 15-18, 2013
6) 熊木天児, 竹治智, 宮田英樹ほか : 化学療法を受ける切除不能進行膵癌患者に対する成分栄養剤エレンタール内服の有用性. 膵臓 34 : A158, 2019
7) Mori R, Matsuyama R, Taniguchi K et al : Efficacy of prolonged elemental diet therapy after pancreaticoduodenectomy for pancreatic ductal adenocarcinoma : A pilot prospective randomized trial (UMIN000004108). Clin Nutr ESPEN 34 : 116-124, 2019
8) Fearon K, Strasser F, Anker SD et al : Definition and classification of cancer cachexia : an international consensus. Lancet Oncol 12 : 489-495, 2011
9) Evans WJ, Morley JE, Argiles J et al : Cachexia : a new definition. Clin Nutr 27 : 793-799, 2008

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