先天性サイトメガロウイルス感染症　診療ガイドライン2023

出版社： 診断と治療社
発行日： 2023-10-16
分野： 臨床医学：内科  >  周産期(新生児)
ISBN： 9784787825506
電子書籍版： 2023-10-16 （電子版）
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商品紹介

先天性サイトメガロウイルス（cCMV）感染症に関するエビデンスに基づく「診療ガイドライン」と，専門家による「解説・エキスパートオピニオン」で構成．診療ガイドラインでは，胎児期からフォローアップまで包括した20のCQを，解説・エキスパートオピニオンでは，診断やフォローアップのほか2023年3月に世界初の適応拡大承認を受けた症候性cCMVへのバルガンシクロビル治療に関するQ&Aも掲載．cCMV感染症に関わるすべての医療従事者必携の書．

目次

  • Part I　診療ガイドライン
    ガイドライン作成方法・作成経過
    疾患トピックの基本的特徴
    診療アルゴリズム
    CQと推奨一覧

    クリニカルクエスチョンに対する推奨と解説
    重要臨床課題1：胎児期のリスク評価・診断された場合の対応
     CQ1―1 胎児期の垂直感染予防に啓発（情報提供）は有用か？
     CQ1―2 妊婦抗体スクリーニングは胎児の垂直感染リスク評価に有用か？
     CQ1―3 先天性感染を疑う胎児超音波検査所見は何か？
    重要臨床課題2：早期新生児期～出生後3週の時期における診断
     CQ2―1 症候性感染を疑う契機となる臨床所見は何か？
     CQ2―2 母体抗体検査でサイトメガロウイルス初感染が疑われる場合に，どのように対応するか？
     CQ2―3 妊娠中にどのような異常所見が認められたら，児の尿核酸検査が必要か？
     CQ2―4 先天性感染と診断した場合に，症候性かどうかを判断するための臨床検査は何か？
     CQ2―5 新生児聴覚スクリーニングでリファーであった場合の診断手順は？
     CQ2―6 出生後3週以降に保存検体等で診断するのは有用か？
    重要臨床課題3：治療
     CQ3―1 症候性先天性サイトメガロウイルス感染症にバルガンシクロビル内服は有効か？
     CQ3―2 バルガンシクロビル内服治療の対象となる症候は何か？
     CQ3―3 バルガンシクロビル内服治療の対象となる時期はいつか？
     CQ3―4 どのような症例にガンシクロビル静注が選択されるか？
     CQ3―5 バルガンシクロビル内服治療において，頻度の高い副作用は何か？
     CQ3―6 バルガンシクロビル内服治療において，治療効果の評価項目は何か？
     CQ3―7 バルガンシクロビル内服で治療効果が不十分な場合に抗ウイルス薬の変更は有用か？
    重要臨床課題4：フォローアップ
     CQ4―1 バルガンシクロビル内服治療例の長期フォローアップに必要な評価項目は何か？
     CQ4―2 耳鼻咽喉科的なフォローアップは有用か？
     CQ4―3 無症候性児の眼科的なフォローアップは有用か？
     CQ4―4 無症候性児の精神運動発達のフォローアップは有用か？
    資料：検索式

    Part II　解説・エキスパートオピニオン
    1．サイトメガロウイルス感染総論
    2．サイトメガロウイルス感染症の診断
     A．ウイルス学的診断
     B．先天性サイトメガロウイルス感染症におけるCMV量
     C．先天性サイトメガロウイルス感染症の頭部画像所見
    3．先天性サイトメガロウイルス感染症の治療
     A．治療総論
     B．治験の概要
     C．バルガンシクロビル治療の適正使用の手引き
       バルガンシクロビル治療に関するQ&A
    4．感染対策と生活指導
    5．発達フォローアップ
    6．耳鼻咽喉科診療の実際
    7．患者団体と患者家族支援

    資料：国立研究開発法人 日本医療研究開発機構（AMED）成育疾患克服等総合研究事業―BIRTHDAY
         サイトメガロウイルス，トキソプラズマ等の母子感染の予防と診療に関する研究班
         ホームページ掲載コンテンツ

この書籍の参考文献

参考文献のリンクは、リンク先の都合等により正しく表示されない場合がありますので、あらかじめご了承下さい。

本参考文献は電子書籍掲載内容を元にしております。

Part I 診療ガイドライン

P.9 掲載の参考文献
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7) de Villemeur AB, et al. : Hygiene promotion might be better than serological screening to deal with Cytomegalovirus infection during pregnancy : a methodological appraisal and decision analysis. BMC Infect Dis 2020 ; 20 : 418
 
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P.20 掲載の参考文献
1) Soper DE : Congenital cytomegalovirus infection : an obstetrician's point of view. Clin Infect Dis 2013 ; 57 (Suppl 4) : S171-S173
 
2) Torii Y, et al. : Serological screening of immunoglobulin M and immunoglobulin G during pregnancy for predicting congenital cytomegalovirus infection. BMC Pregnancy Childbirth 2019 ; 19 : 205
 
3) Tanimura K, et al. : Prediction of Congenital Cytomegalovirus Infection in High-Risk Pregnant Women. Clin Infect Dis 2017 ; 64 : 159-165
 
4) Toriyabe K, et al. : Anti-cytomegalovirus immunoglobulin M titer for congenital infection in first-trimester pregnancy with primary infection : a multicenter prospective cohort study. J Perinatol 2017 ; 37 : 1272-1277
 
5) Sert Y, et al. : Antenatal Cytomegalovirus Infection Screening Results of 32,188 Patients in a Tertiary Referral Center : A Retrospective Cohort Study. Fetal Pediatr Pathol 2019 ; 38 : 112-120
 
6) Leruez-Vill M, et al. : Cytomegalovirus infection during pregnancy : state of the science. Am J Obstet Gynecol 2020 ; 223 : 330-349
 
7) Kouri V, et al. : Diagnosis and screening for cytomegalovirus infection in pregnant women in Cuba as prognostic markers of congenital infection in newborns : 2007-2008. Pediatr Infect Dis J 2010 ; 29 : 1105-1110
 
8) Delforge ML, et al. : Presence of Cytomegalovirus in urine and blood of pregnant women with primary infection might be associated with fetal infection. J Clin Virol 2017 ; 90 : 14-17
 
9) Puhakka L, et al. : Primary versus non-primary maternal cytomegalovirus infection as a cause of symptomatic congenital infection-register-based study from Finland. Infect Dis (Lond) 2017 ; 49 : 445-453
 
10) Tanimura K, et al. : Universal screening with use of immunoglobulin G avidity for congenital cytomegalovirus infection. Clin Infect Dis 2017 ; 65 : 1652-1658
 
11) Maltezou PG, et al. : Maternal type of CMV infection and sequelae in infants with congenital CMV : Systematic review and meta-analysis. J Clin Virol 2020 ; 129 : 104518
 
12) Vauloup-Fellous C, et al. : Does hygiene counseling have an impact on the rate of CMV primary infection during pregnancy? Results of a 3-year prospective study in a French hospital. J Clin Virol 2009 ; 46 (Suppl 4) : S49-S53
 
13) Shahar-Nissan K, et al. : Valaciclovir to prevent vertical transmission of cytomegalovirus after maternal primary infection during pregnancy : a randomised, double-blind, placebo-controlled trial. Lancet 2020 ; 396 : 779-785
 
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P.22 掲載の参考文献
1) Hughes BL, et al. : Diagnosis and antenatal management of congenital cytomegalovirus infection. Am J Obstet Gynecol 2016 ; 214 : B5-B11
 
2) Leruez-Ville M, et al. : Cytomegalovirus infection during pregnancy : state of the science. Am J Obstet Gynecol 2020 ; 223 : 330-349
 
3) Imafuku H, et al. : Clinical and ultrasound features associated with congenital cytomegalovirus infection as potential predictors for targeted newborn screening in high-risk pregnancies. Sci Rep 2020 ; 10 : 19706
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5) Faure-Bardon V, et al. : Refining the prognosis of fetuses infected with Cytomegalovirus in the first trimester of pregnancy by serial prenatal assessment : a single-centre retrospective study. BJOG 2020 ; 127 : 355-362
 
P.24 掲載の参考文献
1) Rawlinson WD, et al. : Congenital cytomegalovirus infection in pregnancy and the neonate : consensus recommendations for prevention, diagnosis, and therapy. Lancet Infect Dis 2017 ; 17 : e177-e188
 
2) Luck SE, et al. : Congenital Cytomegalovirus : A European Expert Consensus Statement on Diagnosis and Management. Pediatr Infect Dis J 2017 ; 36 : 1205-1213
 
3) Annelies K, et al. : Results of a multicenter registry for congenital cytomegalovirus infection in Flanders, Belgium : From prenatal diagnosis over neonatal management to therapy. Early Hum Dev 2021 ; 163 : 105499
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P.26 掲載の参考文献
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2) Kilby MD, et al. : Screening for cytomegalovirus infection in pregnancy. BMJ 2019 ; 367 : 16507
 
3) Tanimura K, et al. : Maternal and neonatal screening methods for congenital cytomegalovirus infection. J Obstet Gynaecol Res 2019 ; 45 : 514-521
 
4) Naing ZW, et al. : Congenital cytomegalovirus infection in pregnancy : a review of prevalence, clinical features, diagnosis and prevention. Aust N Z J Obstet Gynaecol 2016 ; 56 : 9-18
 
5) Maltezou PG, et al. : Maternal type of CMV infection and sequelae in infants with congenital CMV : Systematic review and meta-analysis. J Clin Virol 2020 ; 129 : 104518
 
6) Chiopris G, et al. : Congenital cytomegalovirus infection : update on diagnosis and treatment. Microorganisms 2020 ; 8 : 1516
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7) Rawlinson WD, et al. : Congenital cytomegalovirus infection in pregnancy and the neonate : consensus recommendations for prevention, diagnosis, and therapy. Lancet Infect Dis 2017 ; 17 : e177-e188
 
8) Buca D, et al. : Outcome of fetuses with congenital cytomegalovirus infection and normal ultrasound at diagnosis : systematic review and meta-analysis. Ultrasound Obstet Gynecol 2021 ; 57 : 551-559
 
9) Hughes BL, et al. : A Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus Infection. N Engl J Med 2021 ; 385 : 436-444
 
10) Shahar-Nissan K, et al. : Valaciclovir to prevent vertical transmission of cytomegalovirus after maternal primary infection during pregnancy : a randomised, double-blind, placebo-controlled trial. Lancet 2020 ; 396 : 779-785
 
P.27 掲載の参考文献
1) Pereira L, et al. : Intrauterine growth restriction caused by underlying congenital cytomegalovirus infection. J Infect Dis 2014 ; 209 : 1573-1584
 
2) Ito Y, et al. : Risk factors for poor outcome in congenital cytomegalovirus infection and neonatal herpes on the basis of a nationwide survey in Japan. Pediatr Int 2013 ; 55 : 566-571
 
3) Denef M, et al. : First-line noninvasive management of cytomegalovirus primary infection in pregnancy. J Perinat Med 2021 ; 50 : 270-276
 
4) Imafuku H, et al. : Clinical and ultrasound features associated with congenital cytomegalovirus infection as potential predictors for targeted newborn screening in high-risk pregnancies. Sci Rep 2020 ; 10 : 19706
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5) Messinger CJ, et al. : Association Between Congenital Cytomegalovirus and the Prevalence at Birth of Microcephaly in the United States. JAMA Pediatr 2020 ; 174 : 1159-1167
 
6) Minsart AF, et al. : Prenatal findings, neonatal symptoms and neurodevelopmental outcome of congenital cytomegalovirus infection in a university hospital in Montreal, Quebec. J Perinat Med 2020 ; 48 : 234-241
 
7) Tanimura K, et al. : Prediction of Congenital Cytomegalovirus Infection in High-Risk Pregnant Women. Clin Infect Dis 2017 ; 64 : 159-165
 
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10) Buca D, et al. : Outcome of fetuses with congenital cytomegalovirus infection and normal ultrasound at diagnosis : systematic review and meta-analysis. Ultrasound Obstet Gynecol 2021 ; 57 : 551-559
 
11) Hadar E, et al. : Antenatal risk factors for symptomatic congenital CMV disease following primary maternal CMV infection. J Perinat Med 2016 ; 44 : 339-344
 
12) Torii Y, et al. : Serological screening of immunoglobulin M and immunoglobulin G during pregnancy for predicting congenital cytomegalovirus infection. BMC Pregnancy Childbirth 2019 ; 19 : 205
 
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P.30 掲載の参考文献
1) Ronchi A, et al. : Evaluation of clinically asymptomatic high risk infants with congenital cytomegalovirus infection. J Perinatol 2020 ; 40 : 89-96
 
2) Capretti MG, et al. : Role of cerebral ultrasound and magnetic resonance imaging in newborns with congenital cytomegalovirus infection. Brain Dev 2014 ; 36 : 203-211
 
3) Foulon I, et al. : Hearing loss in children with congenital cytomegalovirus infection in relation to the maternal trimester in which the maternal primary infection occurred. Pediatrics 2008 ; 122 : e1123-1127
 
4) Fujii T, et al. : Newborn Congenital Cytomegalovirus Screening Based on Clinical Manifestations and Evaluation of DNA-based Assays for In Vitro Diagnostics. Pediatr Infect Dis J 2017 ; 36 : 942-946
 
5) Craeghs L, et al. : Congenital CMV-Associated Hearing Loss : Can Brain Imaging Predict Hearing Outcome? Ear Hear 2021 ; 42 : 373-380
 
6) Czech-Kowalska J, et al. : The Limitations of Cytomegalovirus DNA Detection in Cerebrospinal Fluid of Newborn Infants With Congenital CMV Infection : A Tertiary Care Neonatal Center Experience. Pediatr Infect Dis J 2021 ; 40 : 838-845
 
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P.32 掲載の参考文献
1) Kabani N, et al. : Congenital Cytomegalovirus Infection. J Infect Dis 2020 ; 221 (Suppl1) : S9-S14
 
2) Nicloux M, et al. : Outcome and management of newborns with congenital cytomegalovirus infection. Arch Pediatr 2020 ; 27 : 160-165
 
3) Grosse SD, et al. : Congenital cytomegalovirus (CMV) infection as a cause of permanent bilateral hearing loss : a quantitative assessment. J Clin Virol 2008 ; 41 : 57-62
 
4) Dietrich ML, et al. : Congenital Cytomegalovirus Infection. Ochsner J 2019 ; 19 : 123-130
 
5) Stehel EK, et al. : Newborn hearing screening and detection of congenital cytomegalovirus infection. Pediatrics 2008 ; 121 : 970-975
 
6) Chiopris G, et al. : Congenital Cytomegalovirus Infection : Update on Diagnosis and Treatment. Microorganisms 2020 ; 8 : 1516
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7) Shah T, et al. : Fifteen-minute consultation : diagnosis and management of congenital CMV. Archi Dis Child Educ Pract Ed 2016 ; 101 : 232-235
 
8) de Vries JJ, et al. : Real-time PCR versus viral culture on urine as a gold standard in the diagnosis of congenital cytomegalovirus infection. J Clin Virol 2012 ; 53 : 167-170
 
9) Schlesinger Y, et al. : Urine polymerase chain reaction as a screening tool for the detection of congenital cytomegalovirus infection. Arch Dis Child Fetal Neonatal Ed 2003 ; 88 : F371-F374
 
10) Exler Si, et al. : Primary cytomegalovirus (CMV) infection in pregnancy : Diagnostic value of CMV PCR in saliva compared to urine at birth. J Clin Virol 2019 ; 117 : 33-36
 
11) Gantt S, et al. : Diagnosis and management of infants with congenital cytomegalovirus infection. Paediatr Child Health 2017 ; 22 : 72-74
 
12) Eventov-Friedman S, et al. : Saliva Real-Time Polymerase Chain Reaction for Targeted Screening of Congenital Cytomegalovirus Infection. J Infect Dis 2019 ; 220 : 1790-1796
 
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18) Ciccia M, et al. : Usefulness of a flow chart for targeted screening of congenital cytomegalovirus-related hearing loss. J Neonatal Perinatal Med 2018 ; 11 : 339-343
 
19) Williams E, et al. : Feasibility and acceptability of targeted screening for congenital CMV-related hearing loss. Arch Dis Child Fetal Neonatal Ed 2014 ; 99 : F230-F236
 
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P.35 掲載の参考文献
1) Lee ER, et al. : Implications of dried blood spot testing for congenital CMV on management of children with hearing loss : A preliminary report. Int J Pediatr Otorhinolaryngol 2019 ; 119 : 10-14
PubMed
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4) Kadambari S, et al. : Evidence based management guidelines for the detection and treatment of congenital CMV. Early Hum Dev 2011 ; 87 : 723-728
 
5) Luck SE, et al. : Congenital Cytomegalovirus : A European Expert Consensus Statement on Diagnosis and Management. Pediatr Infect Dis J 2017 ; 36 : 1205-1213
 
6) Gantt S, et al. : Diagnosis and management of infants with congenital cytomegalovirus infection. Paediatr Child Health 2017 ; 22 : 72-74
 
7) Gunkel J, et al. : International opinions and national surveillance suggest insufficient consensus regarding the recognition and management practices of infants with congenital cytomegalovirus infections. Acta Paediatr 2017 ; 106 : 1493-1498
 
8) Rawlinson WD, et al. : Congenital cytomegalovirus infection in pregnancy and the neonate : consensus recommendations for prevention, diagnosis, and therapy. Lancet Infect Dis 2017 ; 17 : e177-e188
 
9) Barton M, et al. : Update on congenital cytomegalovirus infection : Prenatal prevention, newborn diagnosis, and management. Paediatr Child Health 2020 ; 25 : 395-396
 
10) Nicloux M, et al. : Outcome and management of newborns with congenital cytomegalovirus infection. Arch Pediatr 2020 ; 27 : 160-165
 
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15) Koyano S, et al. : Congenital cytomegalovirus in Japan : More than 2 year follow up of infected newborns. Pediatr Int 2018 ; 60 : 57-62
 
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18) Corazzi V, et al. : Vestibular and postural impairment in congenital cytomegalovirus infection. Int J Pediatr Otorhinolaryngol 2022 ; 152 : 111005
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Part II 解説・エキスパートオピニオン

P.73 掲載の参考文献
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8) Fujii T, et al. : Newborn congenital cytomegalovirus screening based on clinical manifestations and evaluation of DNA-based assays for in vitro diagnostics. Pediatr Infect Dis J 2017 ; 36 : 942-946
 
9) Kimberlin DW, et al. : Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system : a randomized, controlled trial. J Pediatr 2003 ; 143 : 16-25
 
10) Oliver SE, et al. : Neurodevelopmental outcomes following ganciclovir therapy in symptomatic congenital cytomegalovirus infections involving the central nervous system. J Clin Virol 2009 ; 46 (Suppl 4) : S22-26
 
11) Kimberlin DW, et al. : Valganciclovir for symptomatic congenital cytomegalovirus disease. N Engl J Med 2015 ; 372 : 933-943
 
12) Luck SE, et al. : Congenital cytomegalovirus : A European expert consensus statement on diagnosis and management. Pediatr Infect Dis J 2017 ; 36 : 1205-1213
 
13) Rawlinson WD, et al. : Congenital cytomegalovirus infection in pregnancy and the neonate : consensus recommendations for prevention, diagnosis, and therapy. Lancet Infect Dis 2017 ; 17 : e177-e188
 
14) Morioka I, et al. : Oral valganciclovir therapy in infants aged <- 2 months with congenital cytomegalovirus disease : a multicenter, single-arm, open-label clinical trial in Japan. J Clin Med 2022 ; 11 : 3582
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P.75 掲載の参考文献
1) American Academy of Pediatrics : Cytomegalovirus Infection. In : Kimberlin DW, et al. (eds), Red Book : 2021-2024 Report of the Committee on Infectious Diseases. 32th ed, American Academy of Pediatrics, Elk Grove Village, 2021 ; 294-300
 
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3) 森内浩幸 : サイトメガロウイルス. 日本小児感染症学会 (編), 日常診療に役立つ小児感染症マニュアル 2017. 東京医学社, 2017 ; 267-283
 
4) 日本造血・免疫細胞療法学会ガイドライン委員会 : 造血細胞移植ガイドライン-ウイルス感染症の予防と治療 サイトメガロウイルス感染症 (第5版). 日本造血・免疫細胞療法学会, 2022
 
5) 日本医療研究開発機構 成育疾患克服等総合研究事業-BIRTHDAY サイトメガロウイルス, トキソプラズマ等の母子感染の予防と診療に関する研究班. http://cmvtoxo.umin.jp/
 
P.79 掲載の参考文献
1) Harrioson GJ : Cytomegalovirus. In : Cherry JD, et al. (eds), Feigin and Cherry's Textbook of Pediatric Infectious Diseases. 8th ed, Elsevier, 2019 ; 1429-1450
 
2) Torii Y, et al. : Correlation of cytomegalovirus viral load between whole blood and plasma of congenital cytomegalovirus infection under valganciclovir treatment. BMC Infect Dis 2023 ; 23 : 31
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3) Morioka I, et al. : Oral valganciclovir therapy in infants aged <- 2 months with congenital cytomegalovirus disease : a multicenter, single-arm, open-label clinical trial in Japan. J Clin Med 2022 ; 11 : 3582
PubMed
4) Kimberlin DW, et al. : Valganciclovir for symptomatic congenital cytomegalovirus disease. N Engl J Med 2015 ; 372 : 933-943
 
5) Morioka I, et al. : Efficacy and safety of valganciclovir in patients with symptomatic congenital cytomegalovirus disease : Study Protocol Clinical Trial (SPIRIT Compliant). Medicine (Baltimore) 2020 ; 99 : 17
PubMed
6) 日本医療研究開発機構 成育疾患克服等総合研究事業-BIRTHDAY サイトメガロウイルス, トキソプラズマ等の母子感染の予防と診療に関する研究班. http://cmvtoxo.umin.jp/
 
P.83 掲載の参考文献
1) Capretti MG, et al. : Role of cerebral ultrasound and magnetic resonance imaging in newborns with congenital cytomegalovirus infection. Brain Dev 2014 ; 36 : 203-211
 
2) Suganuma E, et al. : 10-year follow-up of congenital cytomegalovirus infection complicated with severe neurological findings in infancy : a case report. BMC Pediatr 2018 ; 18 : 369
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3) Hedlund GL, et al. : Infections of the developing mature Nervous system. In : Barkovich AJ, et al. (ed), Pediatrc Neuroimaging, 6th ed. Wolters Kluwer, Philadelphia, 2019 ; 1072-1176
 
4) Kidokoro H, et al. : MRI findings in children with congenital cytomegalovirus infection retrospectively diagnosed with dried umbilical cord. Neuroradiology 2021 ; 63 : 761-768
 
5) Vande Walle C, et al. : Brain MRI findings in newborns with congenital cytomegalovirus infection : results from a large cohort study. Eur Radiol 2021 ; 31 : 8001-8010
 
6) Kachramanoglou C, et al. : Diagnostic analysis of baseline brain MRI features in infants with congenital cytomegalovirus infection : a simplified scoring system. Clin Radiol 2021 ; 76 : 942.e7-942.e14
 
7) Nishida K, et al. : Prediction of Neurodevelopmental Impairment in Congenital Cytomegalovirus Infection by Early Postnatal Magnetic Resonance Imaging. Neonatology 2020 ; 117 : 460-466
 
P.85 掲載の参考文献
1) Nagano N, et al. : Congenital cytomegalovirus infection : epidemiology, prediction, diagnosis, and emerging treatment options for symptomatic infants. Expert Opin Orphan Drugs 2020 ; 8 : 1-9
 
2) 森岡一朗 : 感染症 サイトメガロウイルス. 周産期医学 2020 ; 50 (増大号) : 519-523
 
3) Kimberlin DW, et al. : Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system : a randomized, controlled trial. J Pediatr 2003 ; 143 : 16-25
 
4) Kimberlin DW, et al. : Valganciclovir for symptomatic congenital cytomegalovirus disease. N Engl J Med 2015 ; 372 : 933-943
 
5) Nishida K, et al. : Neurological outcomes in symptomatic congenital cytomegalovirus-infected infants after introduction of newborn urine screening and antiviral treatment. Brain Dev 2016 ; 38 : 209-216
 
6) Ohyama S, et al. : Efficacy of valganciclovir treatment depends on the severity of hearing dysfunction in symptomatic infants with congenital cytomegalovirus infection. Int J Mol Sci 2019 ; 20 : 1388
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P.90 掲載の参考文献
1) Morioka I, et al. : Efficacy and safety of valganciclovir in patients with symptomatic congenital cytomegalovirus disease : Study Protocol Clinical Trial (SPIRIT Compliant). Medicine (Baltimore) 2020 ; 99 : e19765
PubMed
2) Morioka I, et al. : Oral valganciclovir therapy in infants aged <- 2 months with congenital cytomegalovirus disease : a multicenter, single-arm, open-label clinical trial in Japan. J Clin Med 2022 ; 11 : 3582
PubMed
P.103 掲載の参考文献
1) Nagano N, et al. : Congenital cytomegalovirus infection : epidemiology, prediction, diagnosis, and emerging treatment options for symptomatic infants. Expert Opin Orphan Drugs 2020 ; 8 : 1-9
 
2) Kimberlin DW, et al. : Valganciclovir for symptomatic congenital cytomegalovirus disease. N Engl J Med 2015 ; 372 : 933-943
 
3) Morioka I, et al. : Efficacy and safety of valganciclovir in patients with symptomatic congenital cytomegalovirus disease : Study Protocol Clinical Trial (SPIRIT Compliant). Medicine (Baltimore) 2020 ; 99 : e19765
PubMed
4) Rawlinson WD, et al. : Congenital cytomegalovirus infection in pregnancy and the neonate : consensus recommendations for prevention, diagnosis, and therapy. Lancet Infect Dis 2017 ; 17 : e177-188
 
5) Luck SE, et al. : Congenital cytomegalovirus-a European expert consensus statement on diagnosis and management. Pediatr Infect Dis J 2017 ; 36 : 1205-1213
 
6) Morioka I, et al. : Oral valganciclovir therapy in infants aged <- 2 months with congenital cytomegalovirus disease : a multicenter, single-arm, open-label clinical trial in Japan. J Clin Med 2022 ; 11 : 3582
PubMed
7) Kimberlin DW, et al. : Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system : a randomized, controlled trial. J Pediatr 2003 ; 143 : 16-25
 
8) Oliver SE, et al. : Neurodevelopmental outcomes following ganciclovir therapy in symptomatic congenital cytomegalovirus infections involving the central nervous system. J Clin Virol 2009 ; 46 (Suppl 4) : S22-S26
 
9) Kimberlin DW, et al. : Pharmacokinetic and pharmacodynamic assessment of oral valganciclovir in the treatment of symptomatic congenital cytomegalovirus disease. J Infect Dis 2008 ; 197 : 836-845
 
10) バリキサ(R) 錠450 mg バリキサ(R) ドライシロップ5000 mg 添付文書 2022年2月改訂 (第2版) https://www.info.pmda.go.jp/go/pack/6250025F1026_1_18/
 
11) Koyano S, et al. : Congenital cytomegalovirus in Japan : More than 2 year follow up of infected newborns. Pediatr Int 2018 ; 60 : 57-62
 
12) Fukushima S, et al. : Prediction of poor neurological development in patients with symptomatic congenital cytomegalovirus diseases after oral valganciclovir treatment. Brain Dev 2019 ; 41 : 743-750
 
13) Hayashi S, et al. : Transmission of cytomegalovirus via breast milk in extremely premature infants. J Perinatol 2011 ; 31 : 440-445
 
P.107 掲載の参考文献
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2) Yamamoto AY, et al. : Congenital cytomegalovirus infection as a cause of sensorineural hearing loss in a highly immune population. Pediatr Infect Dis J 2011 ; 30 : 1043-1046
 
3) Goderis J, et al. : Hearing loss and congenital CMV infection : a systematic review. Pediatrics 2014 ; 134 : 972-982
 
4) Giannattasio A, et al. : Outcomes of congenital cytomegalovirus disease following maternal primary and non-primary infection. J Clin Virol 2017 ; 96 : 32-36
 
5) Puhakka L, et al. : Primary versus non-primary maternal cytomegalovirus infection as a cause of symptomatic congenital infection-register-based study from Finland. Infect Dis (Lond) 2017 ; 49 : 445-453
 
6) Tanimura K, et al. : Universal screening with use of immunoglobulin G avidity for congenital cytomegalovirus infection. Clin Infect Dis 2017 ; 65 : 1652-1658
 
7) Letamendia-Richard E, et al. : Universal newborn screening for congenital cytomegalovirus infection : feasibility and relevance in a French type-III maternity cohort. BJOG 2022 ; 129 : 291-299
 
8) Maltezou PG, et al. : Maternal type of CMV infection and sequelae in infants with congenital CMV : Systematic review and meta-analysis. J Clin Virol 2020 ; 129 : 104518
 
9) Yamada H, et al. : A cohort study of the universal neonatal urine screening for congenital cytomegalovirus infection. J Infect Chemother 2020 ; 26 : 790-794
 
10) Vaudry W, et al. : Congenital cytomegalovirus infection in high-risk Canadian infants : Report of a pilot screening study. Can J Infect Dis Med Microbiol 2012 ; 21 : e12-19
 
11) van der Weiden S, et al. : Is routine TORCH screening and urine CMV culture warranted in small for gestational age neonates? Early Hum Dev 2011 ; 87 : 103-107
 
12) Lorenzoni F, et al. : Neonatal screening for congenital cytomegalovirus infection in preterm and small for gestational age infants. J Matern Fetal Neonatal Med 2014 ; 27 : 1589-1593
 
13) Tanimura K, et al. : Prediction of congenital cytomegalovirus infection in high-risk pregnant women. Clin Infect Dis 2017 ; 15 : 159-165
 
14) Yamada H, et al. : Clinical factor associated with congenital cytomegalovirus infection in pregnant women with non-primary infection. J Infect Chemother 2018 ; 24 : 702-706
 
15) Uchida A, et al. : Clinical factors associated with congenital cytomegalovirus infection : A cohort study of pregnant women and newborns. Clin Infect Dis 2020 ; 71 : 2833-2839
 
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9) Kidokoro H, et al. : MRI findings in children with congenital cytomegalovirus infection retrospectively diagnosed with dried umbilical cord. Neuroradiology 2021 ; 63 : 761-768
 
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