血液・固形腫瘍診断マニュアル 改訂版

出版社: フジメディカル出版
著者:
発行日: 2002-10-01
分野: 臨床医学:内科  >  内科学一般
ISBN: 4939048195
電子書籍版: 2002-10-01 (第1版第1刷)
書籍・雑誌
≪全国送料無料でお届け≫
品切れ

4,860 円(税込)

電子書籍
章別単位で購入
ブラウザ、アプリ閲覧

2,430 円(税込)

商品紹介

造血器腫瘍の治療においては、一部白血病・リンパ腫などのように、分子標的療法や抗体療法が一般化し、飛躍的に予後が改善した疾患軍も出現している。今後、分子生物学、免疫学的手法を駆使した詳細な診断が、より的確な治療に結びつくのは明白である。今回改訂を行った本書が、このような診療の中で役立つことを心から期待したい。

目次

  • 表紙
  • 編者・執筆者一覧
  • 目次
  • 1. 細胞形態、細胞化学に基づく診断
  • 2. 遺伝子診断法
  • 1) ブロッティング法
  • 2) 遺伝子増幅法
  • ポリメラーゼ連鎖反応 (PCR)
  • PCR法を用いた遺伝子変異の検出
  • 遺伝子再構成の検出
  • 点突然変異の検出
  • (1) PCR-SSCP
  • (2) 変異プライマー法
  • (3) 変性濃度勾配ゲル電気泳動法
  • PCRを用いたLOH解析
  • PCRを用いたクローナリティ解析
  • 定量的PCR法
  • (1) competitive PCR法
  • (2) リアルタイムPCR
  • 3) DNAチップ法
  • 3. 腫瘍の遺伝子検査と倫理
  • 4. 染色体検査法
  • 1) 分染法
  • 2) FISH法、間期核FISH法
  • 3) SKY法
  • 5. 細胞免疫学的診断法
  • 1) フローサイトメトリー
  • 2) CD45ゲーティングを用いた解析
  • 6. タンパク分析法
  • SDS-PAGE、ウェスタン法、免疫沈降
  • 7. 検査用検体の処理と保存
  • 1) 造血器腫瘍 (血液・骨髄)
  • 2) 固形腫瘍
  • <カラー図譜>
  • 8. 腫瘍の遺伝子・免疫学的診断と臨床的意義
  • 1) 造血器腫瘍
  • 急性骨髄性白血病
  • 急性リンパ性白血病
  • 慢性骨髄性白血病
  • 成人T細胞白血病
  • 悪性リンパ腫
  • 骨髄腫
  • 骨髄異形成症候群
  • 2) 固形腫瘍
  • 9. 遺伝子・免疫学的検査の治療への応用
  • 1) 微小残存病変の診断
  • 造血器腫瘍
  • (1) PCR法を用いた診断
  • (2) 細胞免疫学的手法を用いた診断
  • 固形腫瘍のMRD
  • 小児固形腫瘍 (神経芽腫、横紋筋肉腫、Ewing肉腫など)
  • 2) 造血幹細胞移植における応用
  • 3) 血液腫瘍に伴う感染症診断への応用
  • 文献
  • <参考資料>
  • 染色体模式図
  • 造血器腫瘍において染色体転座・逆位により再構成を受ける遺伝子一覧
  • 細胞免疫診断に役立つモノクローナル抗体の一覧表
  • 診断によく用いられる表面マーカーの組み合わせ例と分化度の評価
  • 索引
  • 奥付

おすすめ商品

この書籍の参考文献

参考文献のリンクは、リンク先の都合等により正しく表示されない場合がありますので、あらかじめご了承下さい。

本参考文献は電子書籍掲載内容を元にしております。

1. 細胞形態、細胞化学に基づく診断

P.6 掲載の参考文献
2) Shafer JA:Preparation of blood films for examination. in Clinical hematology Principles, procedures, correlations, Lippincott, Philadelphia, 1998

2. 遺伝子診断法

P.12 掲載の参考文献
8) van Dongen JJ et al:Arialysis of immunoglobulin and T-cell receptor genes. Part Basic and technical aspects. Clin Chim Acta 198:1, 1991
9) Beishuizen A et al:Detection of immunoglobulin heavy-chain gene rearrangements by Southern blot analysis:recommendations for optimal result. Leukemia 7:2045, 1993
16) Hansen-Hagge TE et al:Detection of minimal residual disease in acute lymphoblastic leukemia by in vitro amplification of rearranged T-cell receptor delta chain sequences. Blood 74(5):1762, 1989
20) Akasaka T et al:Application of long-distance polymerase chain reaction to detection of junctional sequences created by chromosomal translocation in mature B-cell neoplasms. Blood 88(3):985, 1996
22) Miyoshi H et al:The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. EMBO J 12(7):2715, 1993
24) Inoue K et al:WT1 as a new prognostic factor and a new marker for the detection of minimal residual disease in acute leukemia. Blood 84(9):3071, 1994
29) Borrensen AL et al:Detection of base mutation in genomic DNA using denaturing gradient gel electrophoresis (DGGE) followed by transfer and hybridization with gene-specific probes. Mutat Res 202:77, 1988
30) Borrensen AL et al:Constant denaturing gel electrophoresis as a rapid screening technique for p53 mutations. Proc Natl Acad Sci 88:8405, 1991
32) Pongers-Willemse MJ et al:Primers and protocols for standardized detection of minimal residual disease in acute lymphoblastic leukemia using immunoglobulin and T cell receptor gene rearrangements and TAL1 deletions as PCR targets. Leukernia 13:110, 1999
33) Briet TM et al:Human T cell leukemias with continuous V(D)J recombinase activity for TCR-δ gene deletion. J Immunol 159:4341, 1997
35) Breit TM et al:Extensive junctional diversity of γδ T-cell receptors expressed by T-cell acute lymphoblastic leukemia:implications for the detection of minimal residual disease. Leukemia 5:1076, 1991
36) Bottaro M et al:Heteroduplex analysis of T cell receptor γ gene rearrangements for diagnosis and monitoring of cutaneous T cell lymphomas. Blood 83:3271, 1994
37) Kneba M et al:Analysis of rearranged T-cell receptor β-chain genes by polymerase chain reaction (PCR) DNA sequencing and automated high resolution PCR fragment analysis. Blood 86:3930, 1995
40) Gause WC et al:Use of PCR quantitate relative differences in gene expression. PCR PRIMER, 1995, p293
43) Siebert PD et al:PCR MIMICs:Competitive DNA fragments for use in quantitative PCR. PCR2 Chapter 8, 1995, p135
44) 川上文清ほか:増幅産物の定量 (2)定量的PCR. 蛋白質 核酸 酵素 41(5):503, 1996
45) 中山広樹:細胞工学別冊 バイオ実験イラストレイテッド(3)+ 本当にふえるPCR 第8章, 秀潤社, 東京, 1998, p141
46) Tchirkov A et al:Interphase cytogenetics and competitive RT-PCR for residual disease monitoring in patients with chronic myeloid leukemia during interferon-α therapy. Br J Haematol 101:552, 1998
48) Kuhr T et al:Detection and quantitation of genetically marked acute myeloid leukemia by competitive polymerase chain reaction after autologous bone marrow transplantation. Experimental Hematology 27:266, 1999
50) Freeman WM et al:Quantitative RT-PCR:Pitfalls and Potential. BioTechniques 26:112, 1999
52) 島田 敦ほか:急性リンパ性白血病患者におけるcompetitive RT-PCR法を用いたWT1遺伝子mRNAの定量, 日本臨床血液学会, 第38回総会, 演題番号261, 1996
53) 島田 敦ほか:急性白血病患者における競合RT-PCR法を用いたflt3 mRNAの定量, 日本臨床血液学会, 第39回総会, 演題番号83, 1997
54) 島田 敦ほか:BCR/ABLキメラmRNAの次世代遺伝子検出システムによる定量, 日本血液学会, 第60回総会, 演題番号222, 1998
55) Hochhaus A et al:Molecular heterogeneity in complete cytogenetic responders after interferon-α therapy for chronic myelogenous leukemia. Blood 95(1):62, 2000
56) Tobal K et al:Molecular quantitation of minimal residual disease in acute myeloid leukemia with t(8;21) can identify patients in durable remission and predict clinical relapse. Blood 95(3):815, 2000
58) Campanini F et al:Competitive polymerase chain reaction as a method to detect the amplification of bcr-abl gene of chronic myeloid leukemia. Haematologica 86(2):167, 2001
61) Kreuzer KA et al:Light Cycler technology for the quantitation of bcr/abl fusion transcripts. Cancer Res 59:3171, 1999
67) Mattano LA Jr et al:Sensitive detection of rare circulating neuroblastoma cells by the reverse transcriptase-polymerase chain reaction. Cancer Res 52:4701, 1992

4. 染色体検査法

P.78 掲載の参考文献
1) 桜井雅温:白血病の染色体に関する国際ワークショップ. 腫瘍染色体アトラス (阿部達生ほか編), 南江堂, 東京, 1986, p147
2) Hook EB:Exclusion of chromosomal mosaicism:table of 90%, 95% and 99% confidence limits and comments on use. Am J Hum Genet 29:94, 1977

5. 細胞免疫学的診断法

P.96 掲載の参考文献
1) 河本圭司ほか編:フローサイトメトリー入門, 医学書院, 東京, 1989
2) Sun T:Color atlas-Text of flow cytometric analysis of hematologic neoplasms, New York, IGAKU-SHOIN, 1993
3) Rothe G, Schmitz G for the Working Group on Flow Cytometry and Image Analysis:Consensus protocol for the flow cytometric immunophenotyping of hematopoietic malignancies. Leukemia 10:877, 1996
7) 新堂隆人ほか:CD45白血病細胞同定におけるその有用性について(第一報). 第33回日本臨床病理学会近畿支部総会抄録集, 1990, p87
8) Johannson A et al:Phenotypic transition of CD4+ Tcells from CD45RA to CD45RO is accompanied by cell activation and proliferation. Cytometry 19:343, 1995

6. タンパク分析法

P.110 掲載の参考文献

7. 検査用検体の処理と保存

P.118 掲載の参考文献
3) Diaz-Cano SJ et al:DNA extraction from formalin-fixed, Paraffin-embedded tissues:protein digestion as a limiting step for retrieval of high-quality DNA. Diagn Mol Pathol 6(6):342, 1997
4) Lasota J et al:Detection of the SYT-SSX fusion transcripts in formaldehyde-fixed, paraffin-embedded tissue:a reverse transcription polymerase chain reaction amplification assay useful in the diagnosis of synovial sarcoma. Mod Pathol 11(7):626, 1998
7) 渡辺慶一ほか編:酵素抗体法, 改訂4版, 学際企画, 2002
8) 野口雅之:分子生物学的手法に用いる検体の保存. 病理と臨床 14(臨時増刊号):234, 1996
9) 日本病理学会編:病理組織標本作製技術. 病理技術マニュアル3, 医歯薬出版, 東京, 1981
10) 中山広樹ほか:バイオ実験イラストレイテッド, 第1巻, 秀潤社, 東京, 1995
11) 渋谷 誠ほか:細胞診標本を用いたfluorescence in situ hybridization (FISH) によるinterphase cytogeneticsの実際. 病理と臨床 12(4):475, 1994
12) 日本病理学会編:細胞診とその技術. 病理技術マニュアル6, 医歯薬出版, 東京, 1981
13) 日本組織培養学会編:組織培養の技術, 第3版, 基礎編, 朝倉書店, 東京, 1996
14) 武部 啓編:ヒト培養細胞および染色体診断マニュアル, 講談社サイエンティフィク, 東京, 1990

8. 腫瘍の遺伝子・免疫学的診断と臨床的意義

P.140 掲載の参考文献
4) Rowley JD:Identificaton of a translocation with quinacrine fluorescence in a patient with acute leukemia. Ann Genet 16(2):109, 1973
5) Miyoshi H et al:The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript EMBO J 12(7):2715, 1993
7) Grimwade D et al:The importance of diagnostic cytogenetics on outcome in AML:analysis of 1, 612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties. Blood 92(7):2322, 1998
10) Huang ME et al:Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood 72(2):567, 1988
13) Arthur DC et al:Panial deletion of the long arm of chromosome 16 and bone marrow eosinophuia in acute noriymphocytic leukemia:a new association. Blood 61(5):994, 1983
15) Rubnitz JE et al:11q23 rearrangements in acute leukemia. Leukemia 10(1):74, 1996
16) Soekaman D et al:The translocation (6;9)(p23;q34) shows consistent rearrangement of two genes and defines a myeloproliferative disorder with specific clinical features. Blood 79(11):2990, 1992
17) Lee-EJ et al:Clinical and cytogenetic correlations of abnormal megakaryocytopoiesis in patients with acute leukemia and chronic myelogenous leukemia in blast crisis. Leukemia 4(5):350, 1990
18) Suzukawa K et al:Identification of a breakpoint cluster region 3' of the ribophorin I gene at 3q21 associated with the transcriptional activation of the EVI1 gene in acute myelogenous leukemias with inv(3)(q21q26). Blood 84(8):2681, 1994
19) Bos JL:ras oncogenes in human cancer:a review. Cancer Res 49(17):4682, 1989
20) Tobal K et al:Mutation of the human FMS gene (M-CSF receptor )in myelodysplastic syndromes and acute myeloid leukemia. Leukemia 4(7):486, 1990
22) Nakao M et al:Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia 10:1811, 1996
24) 奈良信雄:ALLの診断プロトコル. Medical Technology 27(1):6, 1999
25) Morphologic, immunologic, and cytogenetic (MIC) working classification of acute lymphoblastic leukernias. Report of the workshop held in Leuven, Belgium, April 22-23, 1985. First MIC Cooperabive Study Group. Cancer Genet Cytogenet 23(3):189, 1986
26) Harris NL et al:A revised European-American classification of lymphoid neoplasms:a proposal from the International Lymphoma Study Group. Blood 84(5):1361, 1994
28) 大島年照:急性白血病の診断. MP 15(3):435, 1998
29) 柵木信男ほか:2:染色体診断による臨床応用, B:急性リンパ性白血病. 臨床染色体診断法(古庄敏行ほか編), 金原出版, 東京, 1996, p600
30) Adolfo A et al:Clinical implications of recurring chromosomal and associated molecular abnormalities in acute lymphoblastic leikemia. Seminar Hematol 37(4):381, 2000
31) 清井 仁:免疫グロブリン遺伝子による微量残存白血病細胞の診断. 別冊医学のあゆみ(血液疾患 Ver.2-State of arts):297, 1998
33) Filipits M et al:Clinical relevance of drug resistant genes in malignant disease. Leukemia 10(Suppl 3):s10, 1996
35) 喜多嶋康一:慢性骨髄性白血病. 最新内科学大系 19 白血病 (山村雄一ほか監修), 中山書店, 東京, 1992, p145
36) Chronic myeloid leukemia. in Cancer Cytogenetics (Heim S et al eds), 2nd ed, Wiley-Liss, New York, 1995, p33
38) Melo JV:The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype. Blood 88:2375, 1996
39) Pear WS et al:Efficient and rapid induction of a chronic myelogenous leukemialike myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. Blood 92:3780, 1998
40) Lion T:Monitoring of residual disease in chronic myelogenous leukemia:methodological approaches and clinical aspects. Leukemia 10:896, 1996
41) Bernstein R et al:Do chromosome abnormalities determine the type of acute leukemia that develops in CML? Leukemia 4:65, 1990
42) Nakai H et al:Frequent p53 mutations in blast crisis of chronic myelogenous leukemia, especially in myeloid crisis harboring loss of a chromosome 17p. Cancer Res 52:6588, 1992
43) Takahashi N et al:Lineage involvement of stem cells bearing the Philadelphia chromosome in chronic myeloid leukemia in the chronic phase as shown by a combination of fluorescence-activated cell sorting and fluorescence in situ hybridization. Blood 92:4758, 1998
44) Carella AM et al:Autografting with Philadelphia chromosome-negative mobilized hematopoietic progenitor cells in chronic myelogenous leukemia. Blood 93:1534, 1999
45) Cross NCP et al:Competitive polymerase chain reaction to estimate the number of BCR-ABL transcripts in chronic myeloid leukemia patients after bone marrow transplantation. Blood 82:1929, 1993
46) Radich JP et al:Polymerase chain reaction detection of the BCR-ABL fusion transcript after allogenic marrow transplantation for chronic myeloid leukemia:Results and implications in 346 patients. Blood 85:2632, 1995
48) Kantarjian HM et al:Chronic myelogenous leukemia-Progress at the M.D. Anderson Cancer Center over the past two decades and future directions:First Emil J Freireich Award Lecture. Clin Cancer Res 3:2723, 1997
50) Takatsuki K et al:ATL and HTLV-I -related diseases. Adult T-cell leukemia (K Takatsuki ed), Oxford press, London, 1994, p 1
51) Hattori T et al:Surface phenotype of Japanese adult T-cell leukemia cells characterized by monoclonal antibodies. Blood 58:645, 1981
52) Matsuoka M et al:T3 surface molecules on adult T cell leukemia cells are modulated in vivo. Blood 67:1070, 1986
53) Shirono K et al:Profiles of expression of activated cell antigens on peripheral blood and lymph node cells from different clinical stages of adult T-cell leukemia. Blood 73:1664, 1989
54) Suzushima H et al:Double-negative (CD4- CD8-) T cells from adult T-cell leukemia patients also have poor expression of the T-cell receptor alpha beta/CD3 complex. Blood 81:1032, 1993
55) Yoshida M et al:Regulation of HTLV-I gene expression and its roles in ATL development. Adult T-cell leukemia (K Takatsuki ed), Oxford press, London, 1994, p28
56) Tamiya S et al:Two types of defective human T-lymphotropic virus type I (HTLV-I)provirus in adult T cell leukemia. Blood 88:3065, 1996
57) Sakashita A et al:Mutations of the p53 gene in adult T-cell leukemia. Blood 79:477, 1992
58) Hatta Y et al:Homozygous deletions of the p15 (MST2) and p16 (CDKN2/MST1) genes in adult T-cell leukemia. Blood 85:2699, 1995
59) Tamiya S et al:Mutation of CD95 (Fas/Apo-1) genes in adult T-cell leukemia cells. Blood 91:3935, 1998
60) 松岡雅雄:成人T細胞白血病リンパ腫. 悪性リンパ腫治療マニュアル(平野正美ほか編), 南江堂, 東京, 1998, p90
62) 安永純一朗ほか:抗HTLV-I 抗体陽性患者の管理の実際. 治療 84:307, 2002
64) 谷脇雅史:悪性リンパ腫のゲノム異常. 日本内科学会雑誌 90:27, 1999
65) 田丸淳一ほか:表面抗原を用いた悪性リンパ腫の診断-REAL分類に沿って-. 医学のあゆみ 188:901, 1999
66) The Non-Hodgkin's lymphoma classification project. Blood 89:3909, 1997
67) 加納 正:骨髄腫と特発性単クローン性免疫グロブリン血症の境界領域をどのように考えるか. 日本臨床免疫学会会誌 6:352, 1983
68) 加納 正:多発性骨髄腫の臨床. 日本内科学会雑誌 87:1897, 1998
69) 河野道生:多発性骨髄腫. 現代医療 31:1861, 1999
72) Avet-Loiseau H et al:Oncogenesis of multiple myeloma:14q32 and 13q chromosomal abnormalities are not randomly distributed, but correlate with natural history, immunological features, and clinical presentation. Blood 99:2185, 2002
73) Desikan R et al:Results of high-dose therapy for 1000 patients with multiple myeloma:durable complete remissions and superior survival in the absence of chromosome 13 abnormalities. Blood 95:4008, 2000
74) Tricot G et al:Predicting longterm (≧5years) event-free survival in multiple myeloma patients following planned tandem autotransplants. Br J Haematol 116:211, 2002
75) Facon T et al:Chromosome 13 abnormalities identified by FISH analysis and serum β2-microglobulin produce a powerful myeloma staging system for patients receiving high-dose therapy. Blood 97:1566, 2001
76) Fonseca R et al:Biological and prognostic significance of interphase fluorescence in situ hybridization detection of chromosome 13 abnormalities (Δ13) in multiple myeloma:an Eastern Cooperative Oncology Group Study. Cancer Res 62:715, 2002
79) Hallek M et al:Multiple myeloma:Increasing evidence for a multistep transformation process. Blood 91:3, 1998
80) Mahmoud MS et al:Enforced CD19 expression leads to growth inhibition and reduced tumorigenicity. Blood 94:3551, 1999
81) Taniwaki M et al:Nonrandom chromosomal rearrangements of 14q32. 3 and 19p13. 3 and preferential deletion of 1p in 21 patients with multiple myeloma and plasma cell leukemia. Blood 84:2283, 1994
82) Nishida K et al:The Ig heavy chain gene is frequently involved in chromosomal translocations in multiple myeloma and plasma cell leukemia as detected by in situ hybridization. Blood 90:526, 1997
83) Chesi M et al:The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts. Blood 92:3025, 1998
88) Yamashita K et al:Clinical significance of matrix metalloproteinase-7 expression in esophageal carcinoma. Clin Cancer Res 6:1169, 2000

9. 遺伝子・免疫学的検査の治療への応用

P.202 掲載の参考文献
4) van Dongen JJ et al:Analysis of immunoglobuhn and T cell receptor genes. Part I:Basic and techrical aspects. Clin Chim Acta 198:1, 1991
5) Yokota S et al:Use of polymerase chain reactions to monitor minimal residual disease in acute lymphoblastic leukemia patients. Blood 77:331, 1991
6) d'Auriol L et al:In vitro amplification of T cell gamma gene rearrangements:a new tool for the assessment of minimal residual disease in acute lymphoblastic leukemias. Leukemia 3:155, 1989
8) Inoue K et al:WT1 as a new prognostic factor and a new marker for the detection of minimal residual disease in acute leukemia. Blood 84:3071, 1994
11) Coustan-Smith E et al:Clinical importance of minimal residual disease in childhood acute lymphoblastic leukemia. Blood 96(8):2691, 2000
12) Panzer-Grurnayer ER et al:Rapid molecular response during early induction chemotherapy predicts a good outcome in childhood acute lymphoblastic leukemia. Blood 95:790, 2000
13) Brisco MJ et al:Early resistance to therapy during induction in childhood acute lymphoblastic leukemia. Cancer Res 60:5092, 2000
15) Tobal K et al:Molecular quantitation of minimal residual disease in acute myeloid leukemia with t(8;21) can identify patients in durable remission and predict clinical relapse. Blood 95(3):815, 2000
16) Diverio D et al:Early detection of relapse by prospective reverse transcriptase-polymerase chain reaction analysis of the PML/RARalpha fusion gene in patients with acute promyelocydc leukemia enrolled in the GIMEMA-AIEOP multicenter "AIDA" trial. GIMEMA-AIEOP Multicenter "AIDA" Trial. Blood 92(3):784, 1998
17) Mori T et al:A novel monoclonal antibody, KOR-SA3544 which reacts to Philadelphia chromosome-positive acute lymphoblastic leukemia cells with high sensitivity. Leukemia 9:1233, 1995
18) Behm FG et al:Human homologue of the rat chondroitin sulfate proteoglycan, NG2, detected by monoclonal antibody 7.1, identifies childhood acute lymphoblastic leukemias with t(4;11)(q21;q23) or t(11;19)(q23;p13) and MLL gene rearrangements. Blood 87:1134, 1996
20) Coustan-Smith E et al:N-CAM(CD56) expression by CD34+ malignant myeloblasts has implications for minimal residual disease detection in acute myeloid leukemia. Leukemia 7:853, 1993
24) Venditti A et al:Level of minimal residual disease after consolidation therapy predicts outcome in acute myeloid leukemia. Blood 96:3948, 2000
28) Wang Y et al:Expression of Protein Gene Product 9. 5 and Tyrosine Hydroxylase in Childhood Small Round Cell Tumors. Clin Cancer Res 6:551, 2000
30) Chemg IY et al:Quantitation of marrow disease in neuroblastoma by real-time reverse transcription-PCR. Clin Cancer Res 7:1698, 2001
31) 白井千晶:神経芽腫における逆転写PCR法による微小残存腫瘍の検出. 日児誌 101:80, 1997
33) Barr FG:The role of chimeric paired box transcription factors in the pathogenesis of pediatric rhabdomyosarcoma. Cancer Res 59:1711s, 1999
34) 細井 創ほか:横紋筋肉腫の新しい診断マーカー-MyoD1とmyogenin-. 小児科臨床 50:709, 1997
36) 角能庸介ほか:腫瘍特異的キメラmRNAによる軟部肉腫の分子病理学的診断. 小児科臨床 50:729, 1997
37) PBSCT研究会小児分科会内部資料
38) 東 寛ほか:自家造血幹細胞移植術後3ヵ月で肺を中心とした全身転移が確認された神経芽腫の1例. 小児がん 33:473, 1996
40) Gribben JG et al:Detection of residual lymphoma cells by polymerase chain reaction in peripheral blood is significantly less predictive for relapse than detection in bone marrow. Blood 83(12):3800, 1994
42) Hardingham JE et al:Molecular detection of residual lymphoma cells in peripheral blood stem cell harvests and following autologous transplantation. Bone Marrow Transplant 11(1):15, 1993
44) Corradini P et al:Molecular monitoring of minimal residual disease in follicular and mantle cell non-Hodgkin's lymphomas treated with high-dose chemotherapy and peripheral blood progenitor cell autografling. Blood 89(2):724, 1997
46) Kolb HJ et al:Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia. Blood 86(5):2041, 1995
49) 造血幹細胞移植マニュアル(小寺良尚ほか監修), 日本医学館, 1995
50) 大林民典:深在性真菌症の血清診断. 臨床検査 43:157, 1999
51) Obayashi T et al:Plasma (1→3)-β-D-glucan measurement in diagnosis of invasive deep mycosis and fungal febrile episods. Lancet 345:17, 1995
52) 山本善裕ほか:真菌症の抗原検査. Lab Clin Pract 14:112, 1996
53) Yasuoka A et al:(1→3)-β-D-glucan as a quantitative serological marker for Pneumocystis carinii pneumonia. Clin Diagn Lab Immunol 3:197, 1996
55) サイトメガロウイルス感染症. 造血幹細胞移植ガイドライン, 日本造血細胞移植学会編, 1999年7月
56) MM Aspin et al:Comparison of plasma PCR and bronchoalveolar lavage fluid culture for detection of cytomegalovirus infection in adult bone marrow transplant recipients. J Clin Microbiol 32:2266, 1994
59) Lo CY et al:Diagnosing cytomegalovirus disease in CMV seropositive renal allograft recipients:a comparison between the detection of CMV DNAemia by polymerase chain reaction and antigenemiaa by CMV pp65 assay. Clin Transplant 11:286, 1997
60) Matsunaga T et al:Use of PCR serum in diagnosing and monitoring cytomegalovirus reactivation in bone marrow transplant recipients. Int J Haematol 69:105, 1999
61) Honda J et al:Rapid and sesitive diagnosis of cytomegalovirus and Pneumocystis carinii pneumonia in patients with haematological neoplasis by using capillary polymerase chain reaction. Br J Haematol 86:138, 1994
64) Aitken C et al:Use of molecular assays in diagnosis and monitoring of Cytomegalovirus disease following renal transplantation. J Clin Microbiol 37:2804, 1999
67) Stringer JR:Pneumocystis carinii:what is it, exaclly? Clin Microbiol Rev 9:489, 1996
68) Ribes JA et al:PCR detection of Pneumocystis carinii bronchoalveolar lavage specimens:Analysis of sesitivity and specificity. J Clin Microbiol 35:830, 1997
69) Helweg-Larsen J et al:Diagnostic use of PCR for detection of Pneumocystis carinii in oral wash samples. J Clin Microbiol 36:2068, 1998
71) Weig M et al:Usefulness of PCR for diagnosis of Pneumocystis carinii pneumonia in different patient groups. J Clin Microbiol 35:1445, 1997
73) Rabodonirina M et al:Rapid detction of Pneumocystis carinii in bronchoalveolar lavage specimens from human immunodeficiency virus-infected patients:use of a simple DNA extraction procedure and nested PCR. J Clin Microbiol 35:2748, 1997
75) Olsson M et al:Detection of Pneumocystis carinii DNA in sputum and bronchoalveolar lavage samples by polymerase chain reaction. J clin Microbiol 31:221, 1993

最近チェックした商品履歴

Loading...