早期糖尿病Q&A

出版社： 先端医学社
著者：
発行日： 2006-10-20
分野： 臨床医学：内科  >  糖尿病
ISBN： 4884072987
電子書籍版： 2006-10-20 （第1版第1刷）
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早期糖尿病治療について、「Ｑ＆Ａ」形式で実践的に分かりやすく解説。現在のわが国における糖尿病の現状から、生活習慣病のなかの早期糖尿病の位置づけと他疾患とのかかわり、初期のＩＧＴの段階からはじめる糖尿病治療へのアプローチ法など、全３４項目にわたり、具体的に紹介。各項目、それぞれ第一線で活躍する専門医が執筆しました、実地医家の方々にとって必読の書。

目次

  • 早期糖尿病Q&A

    ―目次―

    PART.1　わが国における糖尿病の現状と展望をみる
    　Q1．現在糖尿病の患者さんはどれくらいいますか？
    　Q2．日本人における糖尿病の原因と特徴を教えてください
    　Q3．糖尿病を見過ごすことで起こるリスクについて
    　　　　教えてください
    　Q4．高齢者における耐糖能低下の原因について教えてください
    　Q5．糖尿病の診断基準と診断時のポイントを教えてください
    　Q6．糖尿病と高血圧の発症にはどのような関係がありますか？
    　Q7．糖尿病と酸化ストレスの亢進にはどのような
    　　　　関連性がありますか？

    PART.2　実地医家による糖尿病治療の現状と課題点をみる
    　Q8．糖尿病治療の現状には課題点はありますか？
    　Q9．大規模臨床研究JDCSによる日本人糖尿病患者の
    　　　　最新の知見を教えてください
    　Q10．糖尿病の進行度に応じた薬剤選択のポイントを
    　　　　教えてください
    　Q11．ブドウ糖負荷試験（OGTT）をおこなうことが
    　　　　望ましい患者さんの条件を教えてください
    　Q12．血糖自己測定（SMBG）の意義と正しいやり方を
    　　　　教えてください
    　Q13．服薬が守られないのですが、服薬指導のポイントを
    　　　　教えてください
    　Q14．実地医家から専門医への紹介の時期とその判断の
    　　　　ポイントを教えてください
    　Q15．実地医家による食事療法のポイントを教えてください
    　Q16．実地医家による運動療法のポイントを教えてください

    PART.3　生活習慣病の初期症状としての早期糖尿病をみる
    　Q17．早期糖尿病とはどのような病態ですか？
    　Q18．なぜ糖代謝異常は心疾患の原因となるのですか？
    　Q19．なぜ糖代謝異常は心疾患の原因となるのですか？
    　Q20．なぜ糖代謝異常は脳血管障害の原因になるのですか？
    　Q21．早期糖尿病は血管へどのような影響を及ぼしますか？
    　Q22．早期糖尿病における凝固・線溶・血小板機能異常について
    　　　　教えてください
    　Q23．糖代謝異常と脂肪肝はどのような関連性がありますか？
    　Q24．近年注目されているNASHとはどのような疾患ですか？
    　Q25．早期糖尿病とインスリン分泌障害はどのような
    　　　　関連性がありますか？
    　Q26．インスリン追加分泌の役割とその重要性について
    　　　　教えてください
    　Q27．食後高血糖とインスリン抵抗性はどのような
    　　　　関連性があるのですか？
    　Q28．早期糖尿病と食後高脂血症は
    　　　　どのような関連がありますか？

    PART.4　早期糖尿病からはじめる糖尿病治療の新たな
    　　　　　アプローチをみる
    　Q29．早期糖尿病への新たなアプローチとしての、
    　　　　IGTの段階から始める動脈硬化症発症・進展予防の
    　　　　意義と薬物療法について教えてください
    　Q30．早期糖尿病の治療における速効・短時間型インスリン
    　　　　分泌促進薬の役割は何ですか？
    　Q31．糖尿病患者の食後高脂血症を治療するには
    　　　　どうしたらよいでしょうか？
    　Q32．NASHを合併した糖尿病患者さんの治療法を教えてください
    　Q33．早期糖尿病と診断した患者さんに対する
    　　　　治療説明のポイントを教えてください
    　Q34．早期糖尿病におけるクリ二カルパス作成の
    　　　　意義と方法を教えてください

この書籍の参考文献

参考文献のリンクは、リンク先の都合等により正しく表示されない場合がありますので、あらかじめご了承下さい。

本参考文献は電子書籍掲載内容を元にしております。

PART 1 わが国における糖尿病の現状と展望をみる

P.9 掲載の参考文献
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2) 厚生省保健医療局生活習慣病対策室. 平成9年度, 糖尿病実態調査. 厚生省, 1999
 
3) 厚生統計協会:国民衛生の動向 52:414-417, 2005
 
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P.13 掲載の参考文献
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6) Mitsui R, Fukushima M, Nishi Y et al:Factors responsible for deteriorating glucose tolerance in newly diagnosed type 2 diabetes in Japanese men. Metabolism 55:53-58, 2006
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7) Suzuki H, Fukushima M, Usami M et al:Factors responsible for development from normal glucose tolerance to isolated postchallenge hyperglycemia. Diabetes Care 26:1211-1215, 2003
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8) Knowler WC, Barrett-Connor E, Fowler SE et al:DPP research group, Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engt J Med 346:393-403, 2002
 
P.18 掲載の参考文献
1) 葛谷健, 中川昌一, 佐藤譲ほか:糖尿病の分類と診断基準に関する委員会報告. 糖尿病 42:385-404, 1999
 
2) Expert committee on the diagnosis and classifications of diabetes mellitus:Report of the expert committee on the diagnosis and classifications of diabetes mellitus. Diabetes Care 20:1183-1197, 1997
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3) Tominaga M, Eguchi H, Manaka H et al:Impaired glucose tolerance is a risk factor for cardiovascular disease, but not impaired fasting glucose. The Funagata Diabetes Study. Diabetes Care 22:920-924, 1999
 
4) The DECODE study group:Glucose tolerance and mortality:comparison of WHO and American Diabetes Association diagnostic criteria. Lancet 354:617-621, 1999
 
5) 赤沼安夫, 伊藤千賀子, 岩本安彦ほか:糖尿病の指導区分に関する検討. 日本公衆衛生協会, 東京, 2001
 
P.22 掲載の参考文献
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2) Petersen KF, Befroy D, Dufour S et al:Mitochondrial dysfunction in the elderly:possible role in insulin resistance. Science 300:1140-1142, 2003
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3) Diabetes Prevention Program Research Group:Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393-403, 2002
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1) Kaplan NM, Rose BD:Treatment of hypertension in diabetes mellitus. UpTodate version 13. 1, metabolic syndrome の総説集
 
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3) McFarlane SI, Castro J, Kirpichnikov D et al:Hypertension and diabetes. In:Joslin's Diabetes Mellitus 14th ed, eds. by Khan CR, Weir GC, King GL et al, Lippincott Williams & Wilkins, Philadelphia, 2004, pp.969-974
 
P.32 掲載の参考文献
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2) Beisswenger PJ, Howell SK, O'Dell RM et al:α-Dicarbonyls increase in the postprandial period and reflect the degree of hyperglycemia. Diabetes Care 24:726-732, 2001
 
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PART 2 実地医家による糖尿病治療の現状と課題点をみる

P.38 掲載の参考文献
1) Tamura Y, Tanaka Y, Sato F et al:Effects of diet and exercise on muscle and liver intracellular lipid contents and insulin sensitivity in type 2 diabetic patients. J Clin Endocrinol Metab 90:3191-3196, 2005
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2) Sato F et al:presented at ADA, 2005
 
3) Knowler WC, Hamman RF, Edelstein SL et al:DPP Research Group:Prevention of type 2 diabetes with troglitazone in the Diabetes Prevention Program. Diabetes 54:1150-1156, 2005
 
4) Chiasson JL, Josse RG, Gomis R et al:Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance:the STOP-NIDDM trial. JAMA 290:486-494, 2003
PubMed
5) Uchino H, Niwa M, Shimizu T et al:Impairment of early insulin response after glucose load, rather than insulin resistance, is responsible for postprandial hyperglycemia seen in obese type 2 diabetes:assessment using nateglinide, a new insulin secretagogue. Endocr J 47:639-641, 2000
PubMed
6) Hirose T, Mizuno R, Yoshimoto T:The effects of nateglinide following oral glucose load in impaired glucose tolerance subjects:rapid insulin stimulation by nateglinide in IGT subjects. Endocr J 49:649-652, 2002
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P.44 掲載の参考文献
1) Sone H, Katagiri A, Ishibashi S et al:JD Study Group:Effects of lifestyle modifications on patients with type 2 diabetes:the Japan Diabetes Complications Study (JDCS) study design, baseline analysis and three year-interim report. Horm Metab Res 34:509-515, 2002
 
2) Abate N, Chandalia M:The impact of ethnicity on type 2 diabetes. J Diabetes Complications 17:39-58, 2003
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3) Valsamakis G, Chetty RK, Kumar S:The management of obesity in type 2 diabetes mellitus. Curr Med Res Opin 18 (Suppl 1):S75-S81, 2002
 
4) Nelson KM, Reiber G, Boyko EJ:NHANES III. Diet and exercise among adults with type 2 diabetes:findings from the third national health and nutrition examination survey (NHANES III). Diabetes Care 25:1722-1728, 2002
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5) Sone H, Ito H, Ohashi Y et al:Japan Diabetes Complication Study Group:Obesity and type 2 diabetes in Japanese patients. Lancet 361:85, 2003
 
6) Saydah SH, Fradkin J, Cowie CC:Poor control of risk factors for vascular disease among adults with previously diagnosed diabetes. JAMA 291:335-342, 2004
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7) Sone H, Yoshimura Y, Ito H et al:Energy intake and obesity in Japanese patients with type 2 diabetes. Lancet 363:248-249, 2004
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8) Samanta A, Burden AC, Jagger C:A comparison of the clinical features and vascular complications of diabetes between migrant Asians and Caucasians in Leicester, U.K. Diabetes Res Clin Pract 14:205-213, 1991
 
9) Burden AC, McNally PG, Feehally J et al:Increased incidence of end-stage renal failure secondary to diabetes mellitus in Asian ethnic groups in the United Kingdom. Diabet Med 9:641-645, 1992
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10) Young BA, Katon WJ, Von Korff M et al:Racial and ethnic differences in microalbuminuria prevalence in a diabetes population:the pathways study. J Am Soc Nephrol 16:219-228, 2005
 
11) Keen H, Lee ET, Russell D et al:The appearance of retinopathy and progression to proliferative retinopathy:the WHO Multinational Study of Vascular Disease in Diabetes. Diabetologia 44 (Suppl 2):S22-S30, 2001
 
12) Tesfaye S, Chaturvedi N, Eaton SE et al:EURODIAB Prospective Complications Study Group:Vascular risk factors and diabetic neuropathy. N Engl J Med 352:341-350, 2005
 
13) Sone H, Mizuno S, Yamada N:Vascular risk factors and diabetic neuropathy. N Engl J Med 352:1925-1927, 2005
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14) Howard AA, Arnsten JH, Gourevitch MN:Effect of alcohol consumption on diabetes mellitus:a systematic review. Ann Intern Med 140:211-219, 2004
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15) Sone H, Mizuno S, Aida R et al:Alcohol use and diabetes mellitus. Ann Intern Med 141:408-409, 2004
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16) Sone H, Yamada N, Mizuno S et al:Requirement for hypertension and hyperlipidemia medication in U.S. and Japanese patients with diabetes. Am J Med 117:711-712, 2004
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18) Kahn R, Buse J, Ferrannini E et al:American Diabetes Association; European Association for the Study of Diabetes. The metabolic syndrome:time for a critical appraisal:joint statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 28:2289-2304, 2005
 
19) Alberti KG, Zimmet P, Shaw J:IDF Epidemiology Task Force Consensus Group. The metabolic syndrome-a new worldwide definition. Lancet 366:1059-1062, 2005
 
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23) Sone H, Mizuno S, Fujii H et al:Japan Diabetes Complications Study. Is the diagnosis of metabolic syndrome useful for predicting cardiovascular disease in asian diabetic patients? Analysis from the Japan Diabetes Complications Study. Diabetes Care 28:1463-1471, 2005
 
24) Sone H, Tanaka S, Ishibashi S et al:Japan Diabetes Complications Study (JDCS) Group:The new worldwide definition of metabolic syndrome is not a better diagnostic predictor of cardiovascular disease in Japanese diabetic patients than the existing definitions. Additional analysis from the Japan Diabetes Complications Study. Diabetes Care 29:145-147, 2006
 
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P.51 掲載の参考文献
1) 弘世貴久:経口内服薬の使い方, プライマリーケアに役立つ糖尿病治療ポイント. 日本医事新報 4193:6-12, 2004
 
2) 松澤佑次, 弘世貴久, 河盛隆造ほか監修:病気がみえるvol.3 代謝内分泌疾患. 医療情報科学研究所編, メディックメディア, 東京, 2004, p. 38
 
3) 弘世貴久:グリニド系薬剤に学ぶインスリン分泌パターンの重要性. 日本臨牀 63:2237-2244, 2005
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4) Igarashi Y, Mita T, Mizuno R et al:Characteristics of Japanese subjects who progress from normal to impaired glucose tolerance. Longitudinal study excluding changes in body weight. Endocr J 52:683-689, 2005
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5) 弘世貴久:速効型インスリン分泌促進薬による食後高血糖管理-α-Glの併用は?, 食後高血糖の病態・診断・治療. Current Therapy 特別号:77-81, 2006
 
6) Uchino H, Niwa M, Shimizu T et al:Impairment of early insulin response after glucose load rather than insulin resistance, is obese type 2 diabetes:assessment using nateglinide, a new insulin secretagogue. Endocr J 47:639-641, 2000
PubMed
7) Kurebayashi S, Watada H, Tanaka Y et al:Efficacy and adverse effects of nateglinide in early type 2 diabetes. comparison with voglibose in a cross-over study. Endocr J 53:213-217, 2006
 
P.56 掲載の参考文献
1) 田嶼尚子:糖尿病ハイリスク群の効率的なスクリーニング:Prog Med 25:15-21, 2005
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2) The DECODA Study (Diabetes Epidemiology:Collaborative Analysis of Diagnostic Criteria in Asia):Cardiovascular risk profile assessment in glucose-intolerant Asian individuals:an evaluation of the World Health Organization two-step strategy. Diabetic Med 19:549-557, 2002
 
3) Nakagami T, Quio Q, Tuomilehto J et al:The fasting plasma glucose cut-point predicting a diabetic 2-h OGTT glucose level depends on the phenotype. Diabetes Res Clin Pract 55:35-43, 2002
 
4) 富永真琴, 中神朋子:実地医療のなかで, どのように食後高血糖をみつけるか? -舟形町 study を踏まえて. Current Therapy 特別号:60-64, 2006
 
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6) 伊藤千賀子:糖尿病の病態と検査. 糖尿病の予防と管理-疫学研究よるアプローチ, 診断と治療社, 東京, 2002, pp.1O-15
 
7) Ko GT, Chan JC, Tsang LW et al:Combined used of fasting plasma glucose and HbA1c predicts the progression to diabetes in Chinese subjects. Diabetes Care 23:1770-1773, 2000
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8) Akutsu T, Mori Y, Itoh Y et al:Potential role of 1.5-Anhydro-D-glucitol in screening for impaired glucose tolerance. Diabetes 54 (Suppl 1):A96, 2005
 
9) Nelson KM, Boyko EJ:Third National Health and Nutrition Examination Survey. Predicting impaired glucose tolerance using common clinical information:data from the Third National Health and Nutrition Examination Survey. Diabetes Care 26:2058-2062, 2003
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10) Spijkerman AM, Adriaanse MC, Dekker JM et al:Diabetic patients detected by population based stepwise screening already have a diabetic cardiovascular risk profile. Diabetes Care 25:1784-1789, 2002
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P.61 掲載の参考文献
1) 清野弘明, 武井泉, 笠谷知宏:1型および2型糖尿病における血糖自己測定の適応, とくにインスリン投与へのフィードバックにおける血糖自己測定の活用と指導. 患者指導のためのSMBGのすべて (改訂第2版), 富永真琴編, 日本医学出版, 東京, 2005, pp.21-24
 
2) 渥美義仁, 門脇孝, SCCTグループ:血糖自己測定と SCCT. 分子糖尿病学の進歩, 門脇孝, 春日雅人, 菅野進ほか編, 金原出版, 東京, 1998, pp.147-150
 
3) 内潟安子:SMBGによるインスリン治療へのフィードバック. プラクティス別冊, SMBG血糖自己測定, 医歯薬出版, 東京, 2001, pp.69-75
 
P.69 掲載の参考文献
1) Araki S, Haneda M, Sugimoto T et al:Factors associated with frequent remission of microalbuminuria in patients with type 2 diabetes. Diabetes 54:2983-2987, 2005
PubMed
2) 日本糖尿病学会編:糖尿病治療ガイド, 2006～2007, 文光堂, 東京
 
3) 日本糖尿病学会編:科学的根拠に基づく糖尿病診療ガイドライン. 南江堂, 東京, 2004
 
4) 日本高血圧学会:高血圧治療ガイドライン, 2004
 
P.75 掲載の参考文献
1) Knowler WC, Barrett-Connor E, Fowler SE et al:Diabetes Prevention Program Research Group:Reduction in the incidence of type 2 diabetes with lifestyle intervention or metoformin. N Engl J Med 346:393-403, 2002
 
2) Tuomilehto J, Lindstrom J, Eriksson J et al:Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose. N Engl J Med 344:1343-1350, 2001
PubMed
3) 日本糖尿病学会編:糖尿病食事療法のための食品交換表, 第6版. 文光堂, 東京, 2002
 
4) Jarvi AE, Karlstom BE, Granfeldt YE et al:Improved glycemic control and lipid profile and normalized fibrinolytic activity on a low-glycemic index diet in type 2 diabetic patients. Diabetes Care 22:10-18, 1999
PubMed
5) 日本糖尿病学会編:糖尿病腎症の食品交換表. 文光堂, 東京, 1998
 
P.80 掲載の参考文献
1) 藤沼宏彰:糖尿病と運動. 医歯薬出版, 東京, 2005
 
2) Tominaga M, Eguchi H, Manaka H et al:Impaired glucose tolerance is a risk factor for cardiovascular disease, but not impaired fasting glucose:the Funagata Diabetes Study. Diabetes Care 22:920-924, 1999
 
3) DECODE study group:Glucose tolerance and cardiovascular mortality:Comparsion of fasting and 2-hour diagnostic criteria. Arch Intern Med 161:397-405, 2001
 
4) Chiasson JL, Josse RG, Gomis R et al:Acarbose treatment and the risk of cardiovascular disease and hypertention in patients with impaired glucose tolerance. JAMA 290:486-494, 2003
 
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7) 清野弘明, 藤沼宏彰:合併症による運動療法の修飾. 糖尿病 47:632-634, 2004
 

PART 3 生活習慣病の初期症状としての早期糖尿病をみる

P.89 掲載の参考文献
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2) Tominaga M, Eguchi H, Manaka H et al:Impaired glucose tolerance is a risk factor for cardiovascular disease, but not impaired fasting glucose. Diabetes Care 22:920-924, 1999
 
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11) Mori Y, Hoshino K, Yokota K et al:Role of hypoadiponectinemia in the metabolic syndrome and its association with post-glucose challenge hyper-free fatty acidemia:A study in prediabetic Japanese men. Endocrine 29:357-361, 2006
 
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3) Mizushige K, Yao L Noma T et al:Alteration in left ventricular diastolic filling and accumulation of myocardial collagen at insulin-resistant prediabetic stage of a type II diabetic rat model. Circulation 101:899-907, 2000
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4) Celentano A, Vaccaro O, Tammaro P et al:Early abnormalities of cardiac function in non-insulin-dependent diabetes mellitus and impaired glucose tolerance. Am J Cardiol 76:1173-1176, 1995
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5) Petrova R, Yamamoto Y, Muraki K et al:Advanced glycation endproduct-induced calcium handling impairment in mouse cardiac myocytes. J Mol Cell Cardiol 34:1425-1431, 2002
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6) Frustaci A, Kajstura J, Chimenti C et al:Myocardial cell death in human diabetes. Circ Res 87:1123-1132, 2000
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7) Wakasaki H, Koya D, Schoen FJ et al:Targeted overexpression of protein kinase C β2 isoform in myocardium causes cardiomyopathy. Proc Natl Acad Sci USA 94:9320-9325, 1997
 
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9) Iribarren C, Karter AJ, Go AS et al:Glycemic control and heart failure among adult patients with diabetes. Circulation 103:2668-2673, 2001
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10) Stratton IM, Adler Al, Neil HA et al:Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35):prospective observational study. BMJ 321:405-412, 2000
 
P.97 掲載の参考文献
1) Kataoka Y, Yasuda S, Morii I et al:Quantitative coronary angiographic studies of patients with angina pectoris and impaired glucose tolerance. Diabetes Care 28:2217-2222, 2005
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2) Norhammar A, Tenerz A, Nilsson G et al:Glucose metabolism in patients with acute myocardial infarction and no previous diagnosis of diabetes mellitus:a prospective study. Lancet 359:2140-2144, 2002
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3) Luscher TF, Creager MA, Beckman JA et al:Diabetes and vascular disease:pathophysiology, clinical consequences, and medical therapy:Part II. Circulation 108:1655-1661, 2003
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4) Esposito K, Nappo F, Marfella R et al:Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans:role of oxidative stress. Circulation 106:2067-2072, 2002
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P.101 掲載の参考文献
1) Alberti KG, Zimmet PZ:Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1:diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15:539-553, 1998
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2) 清原裕, 大久保賢, 谷崎弓裕:血管障害の危険因子としての境界型. 第35回「糖尿病学の進歩」シンポジウム:効率的な一次予防のあり方, 2001
 
3) The DECODE Study Group:Glucose tolerance and cardiovascular mortality:comparison of fasting and 2-hour diagnostic criteria. Arch Intern Med 161:397-405, 2001
 
4) Giugliano D, Ceriello A, Paolisso G:Oxidative stress and diabetic vascular complications. Diabetes Care 19:257-267, 1996
 
5) Ruef J, Liu SQ, Bode C et al:Involvement of aldose reductase in vascular smooth muscle cell growth and lesion formation after arterial injury. Arterioscler Thromb Vasc Biol:20:1745-1752, 2000
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6) Inoguchi T, Battan R, Handler E et al:Preferential elevation of protein kinase C isoform β II and diacylglycerol levels in the aorta and heart of diabetic rats:differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci USA 89:11059-11063, 1992
 
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8) Vinters HV, Berliner JA, Beck DW et al:Insulin stimulates DNA synthesis in cerebral microvessel endothelium and smooth muscle. Diabetes 34:964-969, 1985
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9) Touyz RM:Molecular and cellular mechanisms regulating vascular function and structure-implications in the pathogenesis of hypertension. Can J Cardiol 16:1137-1146, 2000
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10) Verges B:New insight into the pathophysiology of lipid abnormalities in type 2 diabetes. Diabetes Metab 31:429-439, 2005
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11) Carr ME:Diabetes mellitus:a hypercoagulable state. J Diabetes Complications 15:44-54, 2001
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12) Wakisaka M, Nagamachi S, Inoue K et al:Reduced regional cerebral blood flow in aged noninsulin-dependent diabetic patients with no history of cerebrovascular disease:evaluation by N-isopropyl-123l-p-iodoamphetamine with single-photon emission computed tomography. J Diabet Complications 4:170-174, 1990
 
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1) 島袋充生:循環器医が治療する糖尿病と大血管障害. 代田浩之, 野出孝一編, メジカルビュー社, 東京, 2004, pp.298-290
 
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4) Tominaga M, Eguchi H, Manaka H et al:Impaired glucose tolerance is a risk factor for cardiovascular disease, but not impaired fasting glucose. The Funagata Diabetes Study. Diabetes Care 22:920-924, 1999
 
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7) Guzik TJ, Mussa S, Gastaldi D et al:Mechanisms of increased vascular superoxide production in human diabetes mellitus:role of NAD(P)H oxidase and endothelial nitric oxide synthase. Circulation 105:1656-1662, 2002
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9) Shimabukuro M, Higa N, Takasu N et al:A single dose of nateglinide improves post-challenge glucose metabolism and endothelial dysfunction in type 2 diabetic patients. Diabet Med 21:983-986, 2004
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2) Sakamoto T, Yasue H, Ogawa H et al:Association of patency of the infarct-related coronary artery with plasma levels of plasminogen activator inhibitor activity in acute myocardial infarction. Am J Cardiol 70:271-276, 1992
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3) Calles-Escandon J, Mirza SA, Sobel BE et al:Induction of hyperinsulinemia combined with hyperglycemia and hypertriglyceridemia increases plasminogen activator inhibitor 1 in blood in normal human subjects. Diabetes 47:290-293, 1998
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5) Brunt EM:Nonalcoholic steatohepatitis. Semin Liver Dis 24:3-21, 2004
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7) Bedogni G, Miglioli L, Masutti F et al:Prevalence of and risk factors for nonalcoholic fatty liver disease:the Dionysos nutrition and liver study. Hepatology 42:44-53, 2005
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8) Kojima S, Watanabe N, Nomata M et al:Increase in the prevalence of fatty liver in Japan over the past 12 years:analysis of clinical background. J Gastroenterol 38:954-961, 2003
 
9) Hashimoto E, Yatsuji S, Kaneda H et al:The characteristics and natural history of Japanese patient with nonalcoholic fatty liver disease. Hepatol Res 33:72-76, 2005
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P.125 掲載の参考文献
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PART 4 早期糖尿病からはじめる糖尿病治療の新たなアプローチをみる

P.145 掲載の参考文献
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