最新医学別冊　診断と治療のABC112　サルコペニア

出版社： 最新医学社
発行日： 2016-04-25
分野： 臨床医学：一般  >  雑誌
ISSN： 03708241
雑誌名：
特集： サルコペニア
電子書籍版： 2016-04-25
書籍・雑誌
≪全国送料無料でお届け≫
品切れ

5,500 円(税込)

電子書籍
章別単位での購入はできません
ブラウザ、アプリ閲覧

4,950 円(税込)

購入する

目次

  • 最新医学別冊　診断と治療のABC112　サルコペニア

    ―目次―

    特集　サルコペニア

    序論
    MAP:眼で見るサルコペニア

    第１章　概念・定義と疫学
    　サルコペニアの概念・定義
    　AWGS基準によるサルコペニアの頻度

    第２章　病因と病態生理
    　サルコペニア発症の分子機序
    　サルコペニア発症におけるメカニカルストレスの関与
    　サルコペニア発症における神経系の関与
    　サルコペニアと骨代謝
    　サルコペニアとインスリン抵抗性
    　サルコペニアとフレイル
    　百寿者の身体機能とフレイル

    第３章　診断
    　サルコペニアのBIAによる評価
    　サルコペニアのDXAによる評価
    　ロコモティブシンドロームとサルコペニア
    　COPDにおけるサルコペニアの意義
    　肝疾患におけるサルコペニアの意義
    　サルコペニアと慢性腎臓病
    　サルコペニアと糖尿病
    　コラム：サルコペニアと認知症

    第４章　管理・治療
    　サルコペニアと運動
    　サルコペニアと栄養管理
    　サルコペニアに対するアミノ酸栄養
    　サルコペニアに対するビタミンDの可能性
    　サルコペニアに対するグレリンの可能性
    　サルコペニアに対する漢方療法の可能性
    　サルコペニアに対するホルモン療法の可能性
    　サルコペニアに対する電気刺激療法の可能性
    　コラム：サルコペニアと茶カテキン

この書籍の参考文献

参考文献のリンクは、リンク先の都合等により正しく表示されない場合がありますので、あらかじめご了承下さい。

本参考文献は電子書籍掲載内容を元にしております。

第1章 概念・定義と疫学

P.16 掲載の参考文献
1) 鈴木隆雄 : 地域高齢者の余命の規定要因-学際的縦断研究TMIG-LISAから. 日老医誌 38 : 338-340, 2001.
 
2) 葛谷雅文 : 老年医学におけるSarcopenia & Frailtyの重要性. 日老医誌 46 : 279-285, 2009.
 
3) Kasai T, et al : Sex-and age-related differences in mid-thigh composition and muscle quality determined by computed tomography in middle-aged and elderly Japanese. Geriatr Gerontol Int 15 : 700-706, 2015.
PubMed
4) Cruz-Jentoft AJ, et al : Sarcopenia : European consensus on definition and diagnosis Report of the European Working Group on Sarcopenia in Older People. Age Ageing 39 : 412-423, 2010.
 
5) Rosenberg I H : Sarcopenia : origins and cinical relevance. J Nutr 127 : 990S-991S, 1997.
 
6) Morley JE, et al : Sarcopenia. J Lab Clin Med 137 : 231-243, 2001.
PubMed
7) Morley JE, et al : Definition of sarcopenia. In : Sarcopenia (Cruz-Jentoft A J, et al, eds). p8-19. Wiley-Blackwell, NJ, USA, 2012.
 
8) Visser M, et al : Skeletal muscle mass and muscle strength in relation to lower-extremity performance in older men and women. J Am Geriatr Soc 48 : 381-386, 2000.
PubMed
9) Dumurgier J, et al : Slow walking speed and cardiovascular death in well functioning older adults prospective cohort study. BMJ 339 : b4460, 2009.
PubMed
10) Newman AB, et al : Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort. J Gerontol A Biol Sci Med Sci 61 (1) : 72-77, 2006.
 
11) Delmonico MJ, et al : Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with aging in older men and women. J Arn Geriatr Soc 55 : 769-774, 2007.
 
12) Morley JE, et al : Sarcopenia with limited mobility : an international consensus. J Am Med Dir Assoc 12 : 403-409, 2011.
PubMed
13) Liang-Kung Chen, et al : Sarcopenia in Asia : Consensus Report of the Asian Working Group for Sarcopenia J Am Med Dir Assoc 15 : 95-101, 2014.
 
P.24 掲載の参考文献
1) Cruz-Jentoft AJ, et al : Srcopenia : European consensus on definition.
 
2) Chen LK, et al : Sarcopenia in Asia : consensus report of the asian working group for sarcopenia. J Am Med Dir Assoc 15 (2) : 95-101, 2014.
 
3) Fielding R A, et al : Sarcopenia : an Undiagnosed Condition in Older Adults. Current Consensus Definition : Prevalence, Etiology, and Consequences. J Am Med Dir Assoc 12 (4) : 249-256, 2011.
PubMed
4) Morley J E, et al : Society on Sarcopenia, Cachexia and Wasting Disorders Trialist Workshop : Sarcopenia with limited mobility : an international consensus. J Am Med Dir Assoc 12 (6) : 403-409, 2011.
PubMed
5) Shimokata H, et al : A new comprehensive study on aging-the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA). J Epidemiol 10 (Suppl 1) : S1-S9, 2000.
 
6) 下方浩史, 他 : 国立長寿医療研究センター・老化に関する長期縦断疫学研究 (NILS-LSA). 医の歩み 253 (9) : 779-785, 2015.
 
7) 幸篤武, 他 : サルコペニアの疫学II. 最新医 70 : 37-43, 2015.
Medical*Online
8) 谷本芳美 : サルコペニアの疫学I. 最新医 70 : 30-36, 2015.
Medical*Online
9) Sanada K, et al : A cross-sectional study of sarcopenia in Japanese men and women : reference values and association with cardiovascular risk factors. Eur J Appl Physiol 110 : 57-65, 2010
PubMed
10) 幸篤武, 他 : 地域在住高齢者におけるサルコペニアの実態. サルコペニア-成因と対策. 別冊医のあゆみ p11-16, 医歯薬出版株式会社, 東京, 2015.
 
11) 清野諭, 他 : 地域在住高齢者の握力による移動制限能力の識別. 体力科学 60 (3) : 259-268, 2011.
 
12) 下方浩史, 他 : 日常生活機能と骨格筋量, 筋力との関連. サルコペニア-研究の現状と未来への展望. 日老会誌 49 (2) : 195-198, 2012.
 
13) Arai H, et al : Growing research on sarcopenia in Asia. Geriatr Gerontol Int 14 (Suppl 1) : 1-7, 2014.
 
14) 鈴木隆雄他 : 加齢性筋肉減少症 (サルコペニア) の基礎と臨床. Locomotive Pain Fronti 2 (2) : 20-25, 2013.
 
15) 安藤富士子, 他 : 地域在住中高年者のサルコペニア有病率とその10年間の推移. 日未病システム会誌 19 (2) : 1-6, 2013.
Medical*Online
16) 安藤富士子, 他 : サルコペニアの疫学 ; 地域在住高齢者における頻度の現状. Monthly Book Orthopaedics全日本病院出版会 (in print).
 
17) NILS-LSAモノグラフ. <http://www.ncgg.go.jp/department/ep/nilslsahtml.>
 
18) Gao L, et al : Prevalence of Sarcopenia and Associated Factors in Chinese Community-Dwelling Elderly : Comparison Between Rural and Urban Areas. J Am Med Dir Assoc 16 (11) : 1003. e1-6, 2015.
 

第2章 病因と病態生理

P.31 掲載の参考文献
1) Bodine SC, et al : Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol 3 (11) : 1014-1019, 2001.
PubMed
2) Sakuma K, et al : Sarcopenia : Molecular mechanisms and current therapeutic strategies. In : Cell Aging (Perloft J W, et al), pp93-152. Nova Science Publishers, NY, 2011.
 
3) Sakuma K, et al : Serum response factor (SRF)-dependent signaling in regenerating, hypertrophied, and pathological skeletal muscle. Front Pathol Genet 1 (1) : 1-9, 2013.
 
4) Guerci A, et al : Srf-dependent paracrine signals produced by myofibers control satellite cell-mediated skeletal muscle hypertrophy. Cell Metab 15 (1) : 25-37, 2012.
PubMed
5) Sakuma K, et al : Age-related reductions in expression of serum response factor and myocardin-related transcription factor A in mouse skeletal muscles. Biochim Biophys Acta Mol Basis Dis 1782 (7-8) : 453-461, 2008.
 
6) Sakuma K, et al : Current understanding of sarcopenia : possible candidates modulating muscle mass. Pflugers Arch 467 (2) : 213-229, 2015.
PubMed
7) Bodine SC, et al : Identification of ubiquitin ligases required for skeletal muscle atrophy. Science 294 (5547) : 1704-1708, 2001.
PubMed
8) 佐久間邦弘 : サルコペニアの発症機構 最新医 70 (1) : 51-57, 2015.
Medical*Online
9) Sandri M, et al : Signaling pathways regulating muscle mass in ageing skeletal muscle. The role of IGF-1-Akt-mTOR-FoxO pathway. Biogerontology 14 (3) : 303-323, 2013.
PubMed
10) Hwee D T, et al : Maintenance of muscle mass and load-induced growth in Muscle RING Finger 1 null mice with age. Aging Cell 13 (1) : 92-101, 2014.
PubMed
11) Wenz T, et al : Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging. Proc Natl Acad Sci USA 106 (48) : 20405-20410, 2009.
PubMed
12) Sakuma K, et al : p62/SQSTM1 but not LC3 is accumulated in sarcopenic muscle of mice. J Cachexia Sarcopenia Muscle (in press)
PubMed
13) Carnio S, et al : Autophagy impairment in muscle induces neuromuscular junction degeneration and precocious aging. Cell Reports 8 (5) : 1509-1521, 2014.
PubMed
14) Sakuma K, et al : Molecular mechanisms controlling skeletal muscle mass. In : Muscle Cell and Tissue (Sakuma K, ed), pp143-170. InTech, Croatia, 2015.
 
15) Zhou J, et al : GSK-3α is a central regulator of age-related pathologies in mice. J Clin Invest 123 (4) : 1821-1832, 2013.
 
16) Carlson M E, et al : Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells. Nature 454 (7203) : 528-532, 2008,
PubMed
17) Becker C, et al : Myostatin antibody (LY2495655) in older weak fallers : a proof-of-concept, randomised, phase 2 trial. Lancet Diabetes Endocrinol 3 (12) : 948-957, 2015.
PubMed
18) Mercken EM, et al : Of mice and men : the benefits of caloric restriction, exercise, and mimetics. Ageing Res Rev 11 (3) : 390-398, 2012.
PubMed
P.39 掲載の参考文献
1) Delmas M, et al : Mechano-gated ion channels in sensory systems. Cell 155 (2) : 278-284, 2013.
 
2) Nakao R, et al : Ubiquitin ligase Cbl-b is a negative regulator for insulin-like growth factor 1 signaling during muscle atrophy caused by unloading. Mol Cell Biol 29 (17) : 4798-4811, 2009.
PubMed
3) Perrini S, et al : The GH/IGF1 axis and signaling pathways in the muscle and bone : mechanisms underlying age-related skeletal muscle wasting and osteoporosis. J Endcrinol 205 : 201-210, 2010.
 
4) Ikemoto M, et al : Space shuttle flight (STS-90) enhances degradation of rat myosin heavy chain in association with activation of ubiquitin-proteasome pathway. FASEB J 15 : 1279-1281, 2001.
PubMed
5) Nikawa T, et al : Skeletal muscle gene expression in space-flown rats. FASEB J 18 : 522-524, 2004.
PubMed
6) Altun M, et al : Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway. J Biol Chem 285 : 39597-39608, 2010.
PubMed
7) Sadowski CL, et al : GH regulation of IGF-I and suppressor of cytokine signaling gene expression in C2C12 skeletal muscle cells. Endocrinol 142 : 3890-3900, 2001.
 
8) Goldspink G, et al : Gene expression in response to muscle stretch. Clin Orthop Relat Res 403 : 146-152, 2002.
 
9) Hermann M, et al : Hormonal changes in aging men : a therapeutic indication? Exp Gerontol 36 : 1075-1082, 2001.
 
10) Brill KT, et al : Single and combined effects of growth hormone and testosterone administration on measures of body composition, physical performance, mood, sexual function, bone turnover, and muscle gene expression in healthy older men. JClin Endocrinol Metab 87 : 5649-5657, 2002.
 
11) Schuelke M, et al : Myostatin mutation associated with gross muscle hypertrophy in a child. N Engl J Med 250 : 2682-2688, 2004.
 
12) Yarasheski KE, et al : Serum myostatin-immunoreactive protein is increased in 60-92 year old women and men with muscle wasting. J Nutr Health Aging 6 : 343-348, 2002.
PubMed
13) Siriett V, et al : Prolonged absence of myostatin reduces sarcopenia. J Cell Physiol 209 : 866-873, 2006.
PubMed
14) LeBrasseur NK, et al : Myostatin inhibition enhances the effects of exercise on performance and metabolic outcomes in aged mice. J Gerontol A Biol Sci Med Sci 64 : 940-948, 2009.
PubMed
15) Murphy KT, et al : Antibody-directed Myostatin inhibition in 21-mo-old mice reveals novel roles for myostatin signaling in skeletal muscle structure and function. FASEB J 24 : 4433-4442, 2010.
PubMed
16) Andersson D C, et al : Activation of initiation factor 2 by ligands and mutations for rapid docking of ribosomal subunits. EMBO J 14 : 196-207, 2011.
 
17) Romanello V, et al : Mitochondrial fission and remodelhng contributes to muscle atrophy. EMBO J 29 : 1774-1785, 2010.
PubMed
18) Ito N, et al : Activation of calcium signaling through Trpvl by nNOS and peroxynitrite as a key trigger of skeletal muscle hypertrophy. Nat Med 19 (1) : 101-106, 2013.
 
P.45 掲載の参考文献
1) Cruz-Jentoft AJ, et al : Sarcopenia : European consensus on definition and diagnosis : Report of the European Working Group on Sarcopenia in Older People. Age Ageing 39 : 412-423, 2010.
 
2) 原田敦他 : サルコペニア : 定義と診断に関する欧州関連学会のコンセンサス-高齢者のサルコペニアに関する欧州ワーキンググループの報告-の監訳とQ&A. 日老年医会誌 49 : 788-805, 2012.
 
3) Murray L M, et al : Review : neuromuscular synaptic vulnerability in motor neurone disease : amyotrophic lateral sclerosis and spinal muscular atrophy. Neuropathol Appl Neurobiol 36 : 133-156, 2010.
PubMed
4) Valdez G, et al : Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise. Proc Natl Acad Sci USA 107 : 14863-14868, 2010.
PubMed
5) Valdez G, et al : Shared resistance to aging and ALS in neuromuscular junctions of specific muscles. PLoS One 7 : e34640, 2012.
PubMed
6) Wokke JHJ, et al : Morphological changes in the human end plate with age. J Neurol Sci 95 : 291-310, 1990.
 
7) Nagwaney S, et al : Macromolecular connections of active zone material to docked synaptic vesicles and presynaptic membrane at neuromuscular junctions of mouse. J Comp Neurol 513 : 457-468, 2009.
PubMed
8) Chen J, et al : Active zone density is conserved during synaptic growth but impaired in aged mice. J Comp Neurol 520 : 434-452, 2012.
PubMed
9) Tomlinson BE, et al : The numbers of limb motor neurons in the human lumbosacral cord throughout life. J Neurol Sci 34 : 213-219, 1977.
 
10) Kanda K, et al : Overloading a muscle does not alter the rate of motoneuronal loss in aged rats. Neurobiol Aging 17 : 613-617, 1996.
 
11) Molinari F, et al : Truncating neurotrypsin mutation in autosomal recessive nonsyndromic mental retardation. Science 298 : 1779-1781, 2002.
PubMed
12) Stephan A, et al : Neurotrypsin cleaves agrin locally at the synaps. FASEB J 22 : 1861-1873, 2008.
 
13) Drey M, et al : C-terminal Agrin Fragment as a potential marker for sarcopenia caused by degeneration of the neuromuscular junction. Exp Gerontol 48 : 76-80, 2013.
PubMed
14) Hettwer S, et al : Elevated levels of a C-terminal agrin fragment identifies a new subset of sarcopenia patients. Exp Gerontol 48 : 69-75, 2013.
 
15) Butikofer L, et al : Destabilization of the neuromuscular junction by proteolytic cleavage of agrin results in precocious sarcopenia. FASEB J 25 : 4378-4393, 2011.
PubMed
16) Kalinkovich A, et al : Sarcopenia-The search for emerging biomarkers. Ageing Res Rev 22 : 58-71, 2015.
PubMed
17) Scherbakov N, et al : Evaluation of C-terminal Agrin Fragment as a marker of muscle wasting in patients after acute stroke during early rehabilitation. J Cachexia Sarcopenia Muscle DOI : 10.1002/jcsm. 1268, 2015.
 
P.53 掲載の参考文献
1) Kaji H : Linkage between muscle and bone : Common catabolic signals resulting in osteoporosis and sarcopenia Curr Opin Clin Nutr Metab Care 16 : 272-277, 2013.
 
2) He H, et al : Relationship of sarcopenia and body composition with osteoporosis. Osteoporos Int [Epub ahead of print].
 
3) Lloyd SA, et al : Interdependence of muscle atrophy and bone loss induced by mechanical unloading. J Bone Miner Res 29 : 1118-1130, 2014.
PubMed
4) Ormsbee MJ, et al : Osteosarcopenic obesity : the role of bone, muscle, and fat on health. J Cachexia Sarcopenia Muscle 5 : 183-192, 2014.
 
5) Ilich JZ, et al : Osteosarcopenic obesity is associated with reduced handgrip strength, walking abilities, and balance in postmenopausal women. Osteoporos Int 26 : 2587-2595, 2015.
PubMed
6) Carson EL, et al : Vitamin D, muscle function, and cardiorespiratory fitness in adolescents from the young heats study. J Clin Endocrinol Metab 100 : 4621-4628, 2015.
 
7) Sakai S, et al : Vitamin D receptor signaling enhances locomotive ability in mice. J Bone Miner Res 30 : 128-136, 2015.
PubMed
8) Finkelstein JS, et al : Gonadal steroids and body composition, strength, and sexual function in men. N Engl J Med 369 : 1011-1022, 2013.
 
9) Kawao N, et al : Interactions between muscle tissues and bone metabolism. J Cell Biochem 116 : 687-695, 2015.
PubMed
10) Dankbar B, et al : Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice. Nat Med 21 : 1085-1090, 2015.
PubMed
11) Colaianni G, et al : The myokine irisin increases cortical bone mass. Proc Natl Acad Sci USA 112 : 12157-12162, 2015.
PubMed
12) Jedrychowski MP, et al : Detection and quantitation of circulating irisin by tandem mass spectrometry. Cell Metab 22 : 734-740, 2015.
PubMed
13) Rudnicki MA, et al : Wnt signaling in bone and muscle. Bone 80 : 60-66, 2015.
PubMed
14) Murphy MM, et al : Transiently active Wnt/6-catenin signaling is not required but must be silenced for stem cell function during muscle regeneration. Stem Cell Reports 3 : 475-488, 2014.
 
15) Dobs AS, et al : Effects of enobosarm on muscle wasting and physical function in patients with cancer : a double-blind, randomised controlled phase 2 trial. Lancet Oncol 14 : 335-345, 2013.
 
P.62 掲載の参考文献
1) Lexell J, et al : What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15-to 83-year-old men. J Neurol Sci 84 (2-3) : 275-294, 1988.
 
2) Villareal DT, et al : Obesity in older adults : technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society. Am J Clin Nutr 82 (5) : 923-934, 2005.
PubMed
3) 厚生労働省 : 平成25年国民健康・栄養調査結果の概要. <http://www.mhlw.go.jp/stf/houdou/0000067890.html>
Medical*Online
4) 厚生労働科学研究補助金 (長寿科学総合研究事業) 高齢者における加齢性筋肉減弱現象 (サルコペニア) に関する予防対策確立のための包括的研究研究班 : サルコペニア : 定義と診断に関する欧州関連学会のコンセンサス-高齢者のサルコペニアに関する欧州ワーキンググループの報告-の監訳. <http://www.jpn-geriat-soc.or.jp/info/topics/pdf/sarcopenia_EWGSOP_jpn-j-geriat2012.pdf>
 
5) 笹子敬洋, 他 : 1章ホルモン作用と代謝調節12骨格筋. 糖尿病学, p102-108. 西村書店, 東京, 2015.
 
6) Taniguchi CM, et al : Critical nodes in signalling pathways : insights into insulin action. Nat Rev Mol Cell Biol 7 (2) : 85-96, 2006.
PubMed
7) Kadowaki T, et al : SnapShot : Insulin signaling pathways. Cell 148 (3) : 624, 2012.
PubMed
8) Zoncu R, et al : mTOR : from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cel Biol 12 (1) : 21-35, 2011.
 
9) Kubota T, et al : Impaired insuhn signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle. Cell Metab 13 (3) : 294-307, 2011.
PubMed
10) Philippou A, et al : Type I insulin-like growth factor receptor signaling in skeletal muscle regeneration and hypertrophy. J Musculoskelet Neuronal Interact 7 (3) : 208-218, 2007.
PubMed
11) Velloso CP, et al : Insulin-like growth factor-I E peptides : implications for aging skeletal muscle. Scand J Med Sci Sports 20 (1) : 20-27, 2010.
PubMed
12) Schiaffino S, et al : Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway : insights from genetic models. Skelet Muscle 1 (1) : 4, 2011.
PubMed
13) Ferrannini E, et al : Insulin action and age. European Group for the Study of Insulin Resistance (EGIR). Diabetes 45 (7) : 947-953, 1996.
 
14) Houmard JA, et al : Skeletal muscle GLUT4 protein concentration and aging in humans. Diabetes 44 (5) : 555-560, 1995.
PubMed
15) Broughton DL, et al : Review : deterioration of glucose tolerance with age : the role of insulin resistance. Age Ageing 20 (3) : 221-225, 1991.
PubMed
16) Rhodes CJ : Type 2 diabetes-a matter of beta-cell life and death? Science 307 (5708) : 380-384, 2005.
PubMed
17) van Beek AP, et al : The pituitary gland and age-dependent regulation of body composition. J Clin Endocrinol Metab 95 (8) : 3664-3674, 2010.
PubMed
18) Lee CG, et al : Insulin Sensitizers May Attenuate Lean Mas Loss in Older Men with Diabetes. Diabetes Care 34 : 2381-2386, 2011.
 
P.69 掲載の参考文献
1) Fried LP, et al : Frailty in older adults : evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56 (3) : M146-156, 2001.
PubMed
2) Fried LP, et al : Frailty and failure to thrive. In : Principles of Geriatric Medicine and Gerontology (Hazzard WR, et al, eds). p1387-1402. McGraw Hill, New York, 1998.
 
3) Ferrucci L, et al : Clinical problems of aging. In : Harrison's Principles of Internal Medicine (Kasper DL, et al, eds). p73-85. McGraw Hill, New York, 2015.
 
4) Rosenberg IH : Sarcopenia : origins and clinical relevance. J Nutr 127 (5 Suppl) : 990S-991S, 1997.
 
5) Ali S, et al : Sarcopenia, cachexia and aging diagnosis, mechanisms and therapeutic options-a mini-review. Gerontology 60 (4) : 294-305, 2014.
PubMed
6) Marcell TJ, et al : Comparison of GH, IGF-1, and testosterone with mRNA of receptors and myostatin in skeletal muscle in older men. Am J Physiol Endocrinol Metab 281 (6) : E1159-1164, 2001.
PubMed
7) Ferrucci L, et al : The origins of age-related proinflammatory state. Blood 105 (6) : 2294-2299, 2005.
PubMed
8) Kim MK, et al : Vitamin D deficiency is associated with sarcopenia in older Koreans, regardless od obesity : the Fourth Korea National Health and Nutrition Examination Surveys (KNHANES IV) 2009. J Clin Endocrinol Metab 96 (10) : 3250-3256, 2011.
 
9) Bischoff H A, et al : Effects of vitamin D and calcium supplemantetion on falls : a randomized controlled trial. J Bone Miner Res 18 (2) : 343-351, 2003.
 
10) Penninx BW, et al : Depressive symptoms and physical decline in community-dwelling older persons, JAMA 279 (21) : 1720-1726, 1998.
PubMed
P.76 掲載の参考文献
1) 新井康通他 : 百寿者研究. その変遷と展望. 医のあゆみ特集号. 老化と老年疾患-研究・臨床の最前線 253 (9) : 787-792, 2015.
 
2) Gondo Y, et al : Functional status of centenarians in Tokyo, Japan : developing better phenotypes of exceptional longevity. J Gerontol A Biol Sci Med Sci 61 (3) : 305-310, 2006.
PubMed
3) Arai Y, et al : Physical independence and mortality at the extreme limit of life span : supercentenarians study in Japan. J Gerontol A Bio Sci Med Sci 69 (4) : 486-494, 2014.
 
4) Fried LP, et al : Frailty in older adults : evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56 (3) : Ml46-M156, 2001.
 
5) Cress M E, et al : Assessing physical performance in centenarians : norms and an extended scale from the georgia centenarian study. Curr Gerontol Geriatr Res, 2010, Article ID 310610.
 
6) Searle S D, et al : A standard procedure for creating a frailty index. BMC Geriatr 8 : 24, 2008.
PubMed
7) Gu D, et al : Frailty still matters to health and survival in centenarians : the case of China. BMC Geriatr 15 : 159, 2015.
PubMed
8) Walston J, et al : Research agenda for frailty in older adults : toward a better understanding of physiology and etiology : summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc 54 (6) : 991-1001, 2006.
 
9) Franceschi C, et al : Inflammaging and anti-inflammagingr a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev 128 (1) : 92-105, 2007.
PubMed
10) Bruunsgaard H, et al : Elevated levels of tumor necrosis factor alpha and mortality in centenarians. Am J Med 115 (4) : 278-283, 2003.
PubMed
11) Baker DJ, et al : Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 479 (7372) : 232-236, 2011.
PubMed
12) Arai Y, et al : Inflammation, but not telomere length, predicts successfUI ageing at extreme old age : a longitudinal study of semi-supercentenarians. EBioMedicine 2 (10) : 1549-1558, 2015.
 

第3章 診断

P.86 掲載の参考文献
1) Kyle UG, et al : Validation of a bioelectrical impedance analysis equation to predict appendicular skeletal muscle mass (ASMM). Clin Nutr 22 : 537-543, 2003.
PubMed
2) Janssen I, et al : Estimation of skeletal muscle mass by bioelectrical impedance analysis. J Appl Physiol 89 : 465-471, 2000.
PubMed
3) Nemoto YN, et al : Validity of the bioelectrical impedance method for assessing body composition in non-frail and pre-frail older adults. Int J Body Compos Res 10 : 55-62, 2012.
 
4) Gallagher D, et al : Appendicular skeletal muscle mass : effects of age, gender, and ethnicity. J Appl Physiol 83 : 229-239, 1997.
PubMed
5) Cruz-Jentoft AJ, et al : Sarcopenia : European consensus on definition and diagnosis : Report of the European Working Group on Sarcopenia in Older People. Age Ageing 39 : 412-423, 2010.
 
6) 谷本芳美, 他 : 日本人筋肉量の加齢による特徴. 日老年医会誌 47 : 52-57, 2010.
 
7) Tanimoto Y, et al : Association between muscle mass and disability in performing instrumental activities of daily living (IADL) in community-dwelling elderly in Japan. Arch Gerontol Geriatr 54 : e230-233, 2012.
PubMed
8) 谷本芳美, 他 : わが国の地域高齢者におけるサルコペニアについて. 大阪医大誌 72 : 50-61, 2013.
 
9) Baumgartner RN, et al : Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 147 : 755-763, 1998.
PubMed
10) Chen LK, et al : Sarcopenia in Asia : consensus report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc 15 : 95-101, 2014.
 
11) Tanimoto Y, et al : Association between sarcopenia and higher-level functional capacity in daily living in community-dwelling elderly subjects in Japan. Arch Gerontol Geriatr 55 : e9-e13, 2012.
PubMed
P.92 掲載の参考文献
1) 山東勤弥 : 二重エネルギーX線吸収法 (dual energy X-ray absorptiometry ; DEXA) による栄養評価. Nutrition Support Journal 19 : 12-14, 2006.
 
2) Evans WJ, et al : Sarcopenia and age-related changes in body composition and functional capacity. J Nutr 123 : 465-468, 1993.
PubMed
3) Rosenberg IH : Summary comments. Am J Clin Nutr 50 : 1231-1233, 1989.
 
4) Baumgartner RN, et al : Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 147 : 755-763, 1998.
PubMed
5) Sanada K, et al : A cross-sectional study of sarcopenia in Japanese men and women : reference values and association with cardiovascular risk factors. Eur J Appl Physiol 110 : 57-65, 2010.
PubMed
6) Kim YS, et al : Prevalence of Sarcopenia and Sarcopenic Obesity in the Korean Population Based on the Fourth Korean National Health and Nutritional Examination Surveys. J Gerontol A Biol Sci Med Sci 67 : 1107-1113, 2012.
PubMed
7) 真田樹義他 : 日本人成人男女を対象としたサルコペニア簡易評価法の開発. 体力科学 59 : 291-302, 2010.
 
8) 古嶋大詩, 他 : 日本人成人肥満男女を対象としたサルコペニア簡易評価法の開発. 肥満研 21 : 167-176, 2015.
Medical*Online
9) Ido A, et al : Ultrasound-Derived Abdominal Muscle Thickness Better Detects Metabolic Syndrome Risk in Obese Patients than Skeletal Muscle Index Measured by Dual-Energy X-Ray Absorptiometry. PLoS One 10 : e0143858, 2015.
PubMed
10) Rolland Y, et al : Muscle strength in obese elderly women : effect of recreational physical activity in across-sectional study. Am J Clin Nutr 79 : 552-557, 2004.
 
11) Abe T, et al : Age-related, site-specific muscle loss in 1507 Japanese men and women aged 20 to 95 years. J Sports Sci Med 10 : 145-150, 2011.
PubMed
P.99 掲載の参考文献
1) 日本整形外科学会ロコモパンフレット2015. <http://www.joa.or.jp/jp/public/locomo/locomo_pamphlet_2015.pdf>
 
2) Rosenberg IH : Sarcopenia : origins and clinical relevance. J Nutr 127 : 990S-991S, 1997.
PubMed
3) Cruz-Jentoft AJ, et al : Sarcopenia : European consensus on definition and diagnosis : Report of the European Working Group on Sarcopenia in Older People. Age Aging 39 : 412-423, 2010.
 
4) 内閣府 : 平成26年度版高齢社会白書. <http://www8.cao.go.jp/kourei/whitepaper/w-2014/gaiyou/sl_l.html>
 
5) 厚生労働省国民生活基礎調査 2013年
 
6) Nakamura K : A "Super-aged" society and the "Locomotive Syndrome". J Orthop Sci 13 (1) : 1-2, 2008.
PubMed
7) 石橋英明, 他 : ロコモティブシンドロームの実証データの蓄積 高齢者におけるロコモーションチェックの運動機能予見性およびロコモーショントレーニングの運動機能増強効果の検証. 運動器リハ 24 : 77-81, 2013.
Medical*Online
8) 村永信吾 : 立ち上がり動作を用いた下肢筋力評価とその臨床応用. 昭和医会誌 61 : 362-367, 2001.
 
9) 村永信吾 : 2ステップテストを用いた簡便な歩行能力推定法の開発. 昭和医会誌 63 : 301-308, 2003.
 
10) Seichi A, et al : Development of a screening tool for risk of locomotive syndrome in the elderly : the 25-question Geriatric Locomotive Function Scale. J Orthop Sci 17 : 163-172, 2012.
PubMed
11) Chen LK, et al : Sarcopcnia in Asia consensus report of the Asian working group for sarcopenia. J Am Med Dir Assoc 15 : 95-101, 2014.
 
P.107 掲載の参考文献
1) 日本呼吸器学会編 : COPD診断と治療のためのガイドライン 第4版. メディカルレビュー社, 大阪, 2013.
 
2) Fabbri LM, et al : From COPD to chronic systemic inflammatory syndrome? Lancet 370 (9589) : 797-799, 2007.
PubMed
3) Barnes PJ, et al : Systemic manifestations and comorbidities of COPD. Eur Respir J 33 (5) : 1165-1185, 2009.
PubMed
4) 吉川雅則, 他 : COPD : 診断と治療の進歩 III 合併症 (全身併存症) 1. 栄養障害. 日内会誌 101 : 1562-1570, 2012.
 
5) 高齢者における加齢性筋肉減弱現象 (サルコペニア) に関する予防対策確立のための包括的研究研究班 : サルコペニア : 定義と診断に関する欧州関連学会のコンセンサスの監訳とQ&A. 日老会誌 49 : 788-805, 2012.
 
6) Sayer AA, et al : The developmental origins of sarcopenia. J Nutr Health Aging 12 (7) : 427-432, 200 &
 
7) Fletcher C, et al : The natural history of chronic airflow obstruction. Br Med J 1 (6077) : 1645-1648, 1977.
PubMed
8) Jones SE, et al : Sarcopenia in COPD : prevalence, clinical correlates and response to pulmonary rehabilitation. Thorax 70 (3) : 213-218, 2015.
PubMed
9) Cruz-Jentoft AJ, et al : Understanding sarcopenia as a geriatric syndrome. Curr Opin Clin Nutr Metab Care 13 (1) : 1-7, 2010.
PubMed
10) Handschin C, et al : The role of exercise and PGC1 alpha in inflammation and chronic disease. Nature 454 (7203) : 463-469, 2008.
 
11) Maltais F, et al : An Official American Thoracic Society/European Respiratory Society Statement : Update on Limb Muscle Dysfunction in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 189 (9) : e15-62, 2014.
PubMed
12) Swallow EB, et al : Quadriceps strength predicts mortality in patients with moderate to severe chronic obstructive pulmonary disease. Thorax 62 (2) : 115-120, 2007.
PubMed
13) Schols AM, et al : Nutritional assessment and therapy in COPD : a European Respiratory Society statement Eur Respir J 44 : 1504-1520, 2014.
PubMed
14) 塩谷隆信 : COPD : 診断と治療の進歩 IV 治療 3. リハビリテーション. 日内会誌 101 : 1609-1617, 2012.
 
15) 日本呼吸ケアリハビリテーション学会, 他編 : 呼吸リハビリテーションマニュアル-運動療法-第2版. 照林社, 東京, 2012.
 
16) 日本呼吸ケアリハビリテーション学会, 他編 : 呼吸リハビリテーションマニュアル-患者教育の考え方と実践-照林社, 東京, 2007.
 
17) Seymour J, et al : The prevalence of quadriceps weakness in COPD and the relationship with disease severity. Eur Respir J 36 (1) : 81-88, 2010.
PubMed
18) Spruit M A, et al : An offlcial American Thoracic Society/European Respiratory Society statement key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med 188 (8) : e13-64, 2013.
PubMed
19) Wagg K : Unravelling self-management for COPD : what next? Chron Respir Dis 9 (1) : 5-7, 2012.
PubMed
P.113 掲載の参考文献
1) Rosenberg IH : Summary comments. Am J Clin Nutr 50 : 1231-1233, 1989.
 
2) Cruz-Jentoft AJ, et al : Sarcopenia : European consensus on definition and diagnosis : report of the European Working Group on Sarcopenia in Older People. Age Ageing 39 : 412-423, 2010.
 
3) Chen LK, et al : Sarcopenia in Asia : consensus report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc 15 (2) : 95-101, 2014.
 
4) Hanai T, et al : Sarcopenia impairs prognosis of patients with Hver cirrhosis. Nutrition 31 (1) : 193-199, 2015.
 
5) Durand F, et al : Prognostic value of muscle atrophy in cirrhosis using psoas muscle thickness on computed tomography. J Hepatol 60 (6) : 1151-1157, 2014.
PubMed
6) Prado CM, et al : Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts : a population-based study. Lancet Oncol 9 (7) : 629-635, 2008.
PubMed
7) Kim HK, et al : Effects of exercise and amino acid supplementation on body composition and physical function in community-dwelling elderly Japanese sarcopenic women : a randomized controlled trial. J Am Geriatr Soc 60 (1) : 16-23, 2012.
PubMed
8) Katsanos CS, et al : A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am J physiol Endcrinol Metab E381-387, 2006.
 
9) Kaido T, et al : Impact of sarcopenia on survival in patients undergoing living donor liver transplantation. Am J Transplant 13 (6) : 1549-1556, 2013.
PubMed
10) Harimoto N, et al : Sarcopenia as a predictor of prognosis in patients following hepatectomy for hepatocellular carcinoma. Br J Surg 100 (11) : 1523-1530, 2013.
PubMed
P.121 掲載の参考文献
1) Stenvinkel P, et al : Muscle wasting in end-stage renal disease promulgates premature death : established, emerging and potential novel treatment strategies. Nephrol Dial Transplant (in press)
 
2) Verzola D, et al : Apoptosis and myostatin mRNA are upregulated in the skeletal muscle of patients with chronic kidney disease. Kidney Int 79 (7) : 773-782, 2011.
PubMed
3) Martins AM, et al : Food intake assessment of elderly patients on hemodialysis. J Ren Nutr 25 (3) : 321-326, 2015.
PubMed
4) Wang XH, et al : Muscle wasting from kidney failure-A model for cataboUc conditions. Int J Biochem Cell Biol 45 (10) : 2230-2238, 2013.
 
5) Zhang L, et al : IL-6 and amyloid A synergy mediates angiotensin H-induced muscle wasting. J Am Soc Nephrol 20 (3) : 604-612, 2009.
 
6) Garibotto G, et al : Insulin sensitivity of muscle protein metabolism is altered in patients with chronic kidney disease and metabolic acidosis. Kidney Int 88 (6) : 1419-1426, 2015.
PubMed
7) Fouque D, et al : A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease. Kidney Int 73 (4) : 391-398, 2008.
PubMed
8) Di Micco L, et al : Urine creatinine excretion and clinical outcomes in CKD. Clin J Am Soc Nephrol 8 (11) : 1877-1883, 2013.
PubMed
9) Roshanravan B, et al : Creatinine clearance, walking speed, and muscle atrophy : acohort study. Am J Kidney Dis 65 (5) : 737-747, 2015.
 
10) Moon S J, et al : Relationship between Stage of Chronic Kidney Disease and Sarcopenia in Korean Aged 40 Years and Older Using the Korea National Health and Nutrition Examination Surveys (KNHANES IV-2, 3, and V-1, 2), 2008-2011. PLoS One 10 (6) : e030740, 2015.
PubMed
11) Mclntyre CW, et al : Patients receiving maintenance dialysis have more severe functionally significant skeletal muscle wasting than patients with dialysis-independent chronic kidney disease. Nephrol Dial Transplant 21 (8) : 2210-2216, 2006.
 
12) Isoyama N, et al : Comparative associations of muscle mass and muscle strength with mortality in dialysis patients. Clin J Am Soc Nephrol 9 (10) : 1720-1728, 2014.
PubMed
13) Kim JK, et al : Prevalence of and factors associated with sarcopenia in elderly patients with end-stage renal disease. Clin Nutr 33 (1) : 64-68, 2014.
PubMed
14) Pereira RA, et al : Sarcopenia in chronic kidney disease on conservative therapy : prevalence and association with mortality. Nephrol Dial Transplant 30 (10) : 1718-1725, 2015.
PubMed
15) Lamarca F, et al : Prevalence of sarcopenia in elderly maintenance hemodialysis patients : the impact of different diagnostic criteria. J Nutr Health Aging 18 (7) : 710-717, 2014.
 
16) Castaneda C, et al : Resistance training to counteract the catabolism of a low-protein diet in patients with chronic renal insufflciency. Ann Intern Med 135 (11) : 965-976, 2001.
 
17) Greenwood SA, et al : Effect of exercise training on estimated GFR, vascular health, and cardiopulmonary fitness in patients with CKD : A pilot randomized controlled trial. Am J Kidney Dis 65 (3) : 425-434, 2015.
 
18) Dong J, et al : The effect of resistance exercise to augment long-term benefits of intradialytic oral nutritional supplementation in chronic hemodialysis patients. J Ren Nutr 21 (2) : 149-159, 2011.
PubMed
19) Molsted S, et al : The effects of high-load strength training with protein-or nonprotein-containing nutritional supplementation in patients undergoing dialysis. J Ren Nutr 23 (2) : 132-140, 2013.
PubMed
20) Sezer S, et al : Long-term oral nutrition supplementation improves outcomes in malnourished patients with chronic kidney disease on hemodialysis. J Parenter Enteral Nutr 38 : 960-965, 2014.
PubMed
21) Piovezan RD, et al : The impact of sleep on age-related sarcopenia : possible connections and clinical implications. Ageing Res Rev 23 (Pt B) : 210-220, 2015.
 
22) Kim M, et al : Objectively measured night-to-night sleep variations are associated with body composition in very elderly women. J Sleep Res 24 (6) : 639-647, 2015.
PubMed
23) Yamamoto R, et al : Self-reported sleep duration and prediction of proteinuria : a retrospective cohort study. Am J Kidney Dis 59 (3) : 343-355, 2012.
PubMed
24) Sakaguchi Y, et al : Association of nocttlrnal hypoxemia with progression of CKD. Clin J Am Soc Nephrol 8 (9) : 1502-1507, 2013.
PubMed
25) Barmer B, et al : Comparison of sleep/wake behavior in CKD stages 4 to 5 and hemodialysis populations using wrist actigraphy. Am J Kidney Dis 53 (4) : 665-672, 2009.
 
26) Iseki K, et al : Effects of sleepiness on survival in Japanese hemodialysis patients : J-DOPPS study. Nephron Clin Pract 128 (3-4) : 333-340, 2014.
 
27) Giannaki CD, et al : Evidence of increased muscle atrophy and impaired quality of life parameters in patients with uremic restless legs syndrome. PLoS One 6 (10) : e25180, 2011.
PubMed
28) Giannaki CD, et al : A single-blind randomized controlled trial to evaluate the effect of 6 months of progressive aerobic exercise training in patients with uraemic restless legs syndrome. Nephrol Dial Transplant 28 (11) : 2834-2840, 2013.
PubMed
P.128 掲載の参考文献
1) Araki A, et al : Diabetes and geriatric syndromes. Geriatr Gerontol Int 9 : 105-114, 2009.
PubMed
2) Chen LK, et al : Sarcopenia in Asia : consensus report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc 15 : 95-101, 2014.
 
3) Srikanthan P, et al : Sarcopenia exacerbates obesity-associated insuhn resistance and dysglycemia : Findings from the National Health and Nutrition Examination Survey III. PLoS ONE 5 : e10805, 2010.
PubMed
4) Moon SS : Low skeletal muscle mass is associated with insulin resistance, diabetes, and metabolic syndrome in the Korean population : The Korea National Health and Nutrition Examination Survey (KNHANES) 2009-2010. Endocr J 61 : 61-70, 2014.
PubMed
5) Kim TN, et al : Prevalence and determinant factors of sarcopenia in patients with type 2 diabetes. Diabetes Care 33 : 1497-1499, 2010.
PubMed
6) Anbalagan VP, et al : The prevalence of presarcopenia in asian Indian individuals with and without type 2 diabetes. Diabetes Technol Ther 15 : 768-775, 2013.
PubMed
7) Park SW, et al : Excessive loss of skeletal muscle mass in older adults with type 2 diabetes. Diabetes Care 32 : 1993-1997, 2009.
PubMed
8) Park SW, et al : Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes : the health, aging, and body composition study. Diabetes Care 30 : 1507-1512, 2007.
PubMed
9) Lee JS, et al : The effect of diabetes mellitus on age-associated lean mass loss in 3153 older adults. Diabet Med 27 : 1366-1371, 2010.
PubMed
10) Park SW, et al : Decreased muscle strength and quality in older adults with type 2 diabetes : the health, aging, and body composition study. Diabetes 55 : 1813-1818, 2006.
PubMed
11) Kalyani RR, et al : Quadriceps strength, quadriceps power, and gait speed in older U. S. adults with diabetes mellitus : results from the National Health and Nutrition Examination Survey, 1999-2002. J Am Geriatr Soc 61 : 769-775, 2013.
PubMed
12) Chiba Y, et al : Risk factors associated with fans in elderly patients with type 2 diabetes. J Diabetes Complications 29 : 898-902, 2015.
 
13) Wang CP, et al : Better glycemic control is associated with maintenance of lower-extremity function over time in Mexican American and European American older adults with diabetes. Diabetes Care 34 : 268-273, 2011.
PubMed
14) Chiles NS, et al : Diabetes, peripheral neuropathy, and lower-extremity function. J Diabetes Complications 28 : 91-95, 2014.
PubMed
15) Ali S, et al : Sarcopenia cachexia and aging diagnosis, mechanisms and therapeutic options-a mini-review. Gerontology 60 : 294-305, 2014.
PubMed
16) Lee CG, et al : Insulin sensitizers may attenuate lean mass loss in older men with diabetes. Diabetes Care 34 : 2381-2386, 2011.
PubMed
17) Lee CG, et al : Changes in physical performance in older women according to presence and treatment of diabetes melHtus. J Am Geriatr Soc 61 : 1872-1878, 2013.
 
18) Stenholm S, et al : Sarcopenic obesity : definition, cause and consequences. Curr Opin Clin Nutr Metab Care 11 : 693-700, 2008.
PubMed
19) Dela F, et al : Insulin resistance and mitochondrial function in skeletal muscle. Int J Biochem Cell Biol 45 : 11-15, 2013.
PubMed
20) Andersen H, et al : Isokinetic muscle strength in long-term IDDM patients in relation to diabetic complications. Diabetes 45 : 440-445, 1996.
PubMed
21) Andersen H, et al : Association of muscle strength and electrophysiological measures of reinnervation in diabetic neuropathy. Muscle Nerve 21 : 1647-1654, 1998.
PubMed
22) Castaneda C, et al : A randomized controUed trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes. Diabetes Care 25 : 2335-2341, 2002.
 
23) Mavros Y, et al : Changes in insulin resistance and HbA1c are related to exercise-mediated changes in body composition in older adults with type 2 diabetes : interim outcomes from the GREAT2DO trial. Diabetes Care 36 : 2372-2379, 2013.
PubMed
24) Mavros Y, et al : Reductions in C-reactive protein in older adults with type 2 diabetes are related to improvements in body composition following a randomized controlled trial of resistance training. J Cachexia Sarcopenia Muscle 5 : 111-120, 2014.
 
25) Huston DK, et al : Health ABC Study. Dietary protein intake is associated with lean mass change in older, community-dwelling adults : the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr 87 : 150-155, 2008.
 
26) Kim HK, et al : Effects of exercise and amino acid supplementation on body composition and physical function in community-dwelling elderly Japanese sarcopenic women : a randomized controlled trial. J Am Geriatr Soc 60 : 16-23, 2012.
PubMed
27) Wu H, et al : Effect of beta-hydroxy-beta-methylbutyrate supplementation on muscle loss in older adults : A systematic review and meta-analysis. Arch Gerontol Geriatr 61 : 168-175, 2015.
PubMed
28) Muir SW, et al : Efiiect of vitamin D supplementation on muscle strength, gait and balance in older adults : a systematic review and meta-analysis. J Am Geriatr Soc 59 : 2291-2300, 2011.
PubMed
29) Tanner SB, et al : More than healthy bones : a review of vitamin D in muscle health. Ther Adv Musculoskelet Dis 7 : 152-159, 2015.
 
30) Miller GD, et al : Intensive weight loss program improves physical function in older obese adults with knee osteoarthritis. Obesity 14 : 1219-1230, 2006.
PubMed
31) Perna S, et al : Liraglutide and obesity in elderly : efficacy in fat loss and safety in order to prevent sarcopenia. A perspective case series study. Aging Clin Exp Res 2016 [Epub ahead of print]
 
32) Tanaka K, et al : Reduction in endogenous insulin secretion is a risk factor of sarcopenia in men with type 2 diabetes mellitus. Calcif Tissue Int 97 : 385-390, 2015.
PubMed
33) Davis KL, et al : Association between different hemoglobin A1c levels and clinical outcomes among elderly nursing home residents with type 2 diabetes menitus. J Am Med Dir Assoc 15 : 757-762, 2014.
PubMed
34) Puar TH, et al : Association between glycemic control and hip fracture. J Am Geriatr Soc 60 : 1493-1497, 2012.
PubMed
35) Bramlage P, et al : Oral antidiabetic treatment in type-2 diabetes in the elderly : balancing the need for glucose control and the risk of hypoglycemia Cardiovasc Diabetol 11 : 122, 2012.
PubMed
P.131 掲載の参考文献
1) Sugimoto T, et al : Curr Alzheimer Res 2016 [Epub ahead of print]
 
2) Tolea MI, et al : Clin Interv Aging 10 : 663-671, 2015.
PubMed
3) Burns JM, et al : Arch Neurol 67 : 428-433, 2010,
PubMed
4) Wirth R, et al : J Nutr Health Aging 15 (8) : 706-710, 2011.
 
5) Boyle PA, et al : Arch Neurol 66 : 1339-1344. 2009.
PubMed
6) Yoshitake T, et al : Neurology 45 (6) : 1161-1168, 1995.
PubMed

第4章 管理・治療

P.137 掲載の参考文献
1) Bamman MM, et al : Impact of resistance exercise during bed rest on skeletal muscle sarcopenia and myosin isoform distribution. J Appl Physiol 84 (1) : 157-163, 1998.
PubMed
2) Bemben MG, et al : Isometric intermittent endurance of four muscle groups in men aged 20-74 yr. Med Sci Sports Exerc 28 (1) : 145-154, 1996.
PubMed
3) Rubenstein L, et al : Interventions to reduce the multifactorial risks fOr falling, In : Gait disorders of aging falls and therapeutic strategies (Masdeu J, et al, eds). p309-326. Lippincot-Raven, Philadelphia, 1997.
 
4) Lauretani F, et al : Age-associated changes in skeletal muscles and their effect on mobility : an operational diagnosis of sarcopenia. J Appl Physiol 95 (5) : 1851-1860, 2003.
PubMed
5) Melton LJ 3rd, et al : Epidemiology of sarcopenia. J Am Geriatr Soc 48 (6) : 625-630, 2000.
PubMed
6) Tanko LB, et al : Appendicular lean tissue mass and the prevalence of sarcopenia among healthy women. Metabolism 51 (1) : 69-74, 2002.
PubMed
7) Baumgartner RN, et al : Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 147 (8) : 755-763, 1998.
PubMed
8) Iannuzzi-Sucich M, et al : Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. J Gerontol A Biol Sci Med Sci 57 (12) : M772-777, 2002.
PubMed
9) Evans WJ : Exercise strategies should be designed to increase muscle power. J Gerontol A Biol Sci Med Sci 55 (6) : M309-310, 2000.
 
10) Singh MA : Exercise comes of age : rationale and recommendations for a geriatric exercise prescription. J Gerontol A Biol Sci Med Sci 57 (5) : M262-282, 2002.
PubMed
11) Moritani T, et al : Potential for gross muscle hypertrophy in older men. J Gerontol 35 (5) : 672-682, 1980.
 
12) Fiatarone MA, et al : Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med 330 (25) : 1769-1775, 1994.
PubMed
13) Taaffe DR, et al : Dynamic muscle strength alterations to detraining and retraining in elderiy men. Clin Physiol 17 (3) : 311-324, 1997.
PubMed
14) Latham N, et al : Progressive resistance strength training for physical disability in older people. Cochrane Database Syst Rev 2003 (2) : CD002759, 2003.
PubMed
15) Latham NK, et al : Systematic review of progressive resistance strength training in older adults. J Gerontol A Biol Sci Med Sci 59 (1) : 48-61, 2004.
PubMed
16) Shinkai S, et al : Walking speed as a good predictor for the onset of functional dependence in a Japanese rural community population. Age Ageing 29 (5) : 441-446, 2000.
 
17) Shimada H, et al : Which neuromuscular or cognitive test is the optimal screening tool to predict falls in frail community-dwelling older people? Gerontology 55 (5) : 532-538, 2009.
 
18) McGibbon CA : Toward a better understanding of gait changes with age and disablemen : neuromuscular adaptation. Exerc Sport Sci Rev 31 (2) : 102-108, 2003.
 
19) Shimada H, et al : Comparison of regional lower limb glucose metabohsm in older adults during walking. Scand J Med Sci Sports 19 (3) : 389-397, 2009.
 
P.147 掲載の参考文献
1) Xue Q L et al : lnitial manifestations of frailty criteria and the development of frailty phenotype in the Women's Health and Aging Study IL. J Gerontol A Biol Sci Med Sci 63 (9) : 984-990, 2008.
 
2) 葛谷雅文 : Topic 36 高齢者の栄養 Module 36, 2 病理生理-サルコペニア. 静脈経腸栄養 26 (3) : 68-70, 2011.
 
3) 葛谷雅文 : 低栄養. 新老年学第3版. p579-590. 東京大学出版会, 東京, 2010.
 
4) 日本静脈経腸栄養学会編 : 高齢者 ; 静脈経腸栄養ガイドライン 第3版 (2013), p386. 2013.
 
5) Campbell WW, et al : The recommnended dietary allowance for protein may not be adequate for older people to maintain skeletal muscle. J Gerontol A Biol Sci Med Sci 56 (6) : M373-380, 2001.
 
6) 厚生労働省 : 「日本人の食事摂取基準」 (2015年版)
 
7) 厚生労働省 : 平成26年度国民健康・栄養調査の概要
 
8) 井上啓子 : 在宅訪問栄養食事指導による栄養介入方法とその改善効果の検証. 日栄養士会誌 55 (8) : 40-48, 2012.
 
9) 骨粗鬆症の予防と治療ガイドライン 2011年版
 
10) 荒木厚 : 認知症と栄養障害. 老年医 51 : 826-832, 2013.
Medical*Online
11) 真田樹義, 他 : 日本人のサルコペニアの参照値と心血管系疾患リスクおよびメタボリックシンドロームとの関係についての横断的解析. 日老年医会誌 49 : 715-717, 2012.
 
12) Ricci N A, et al : Frailty and cardiovascular risk in community-dwelling elderly : a population-based study. Chn Interv Aging 9 : 1677-1685, 2014.
 
P.155 掲載の参考文献
1) Kobayashi H, et al : Reduced amino acid availability inhibits muscle protein synthesis and decreases activity of initiation factor eIF2B. Am J Physiol Endocrinol Metab 284 (3) : E488-498, 2003.
PubMed
2) Biolo G, et al : Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans. Am J physiol Endocrinol Metab 268 (3 Pt 1) : E514-520, 1995.
 
3) Biolo G, et al : An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein. Am J physiol Endocrinol Metab 273 (l Pt 1) : E122-129, 1997.
 
4) Volpi E, et al : Basal muscle amino acid kinetics and protein synthesis in healthy young and older men. JAMA 286 (10) : 1206-1212, 2001.
 
5) Katsanos CS, et al : Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids. Am J Clin Nutr 82 (5) : 1065-1073, 2005.
PubMed
6) Moore DR, et al : Protein Ingestion to Stimulate Myofibrillar Protein Synthesis Requires Greater Relative Protein Intakes in Healthy Older Versus Younger Men. J Gerontol A Biol Sci Med Sci 70 (1) : 57-62, 2015.
 
7) Houston DK, et al : Dietary protein intake is associated with lean mass change in older, community-dwelling adults : the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr 87 (1) : 150-155, 2008.
PubMed
8) Kobayashi S, et al : High protein intake is associated with low prevalence of frailty among old Japanese women : a multicenter cross-sectional study. Nutr J 12 : 164, 2013.
PubMed
9) Imai E, et al : Animal Protein Intake Is Associated with Higher-Level Functional Capacity in Elderly Adults : The Ohasama Study. J Am Geriatr Soc 62 (3) : 426-434, 2014.
PubMed
10) Paddon-Jones D, et al : Dietary protein recommendations and the prevention of sarcopenia. Curr Opin Clin Nutr Metab Care 12 (1) : 86-90, 2009.
PubMed
11) Mamerow MM, et al : Dietary protein distribution positively influences 24-h muscle protein synthesis in healthy adults. J Nutr 144 (6) : 876-880, 2014.
PubMed
12) Volpi E, et al : Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults. Am J Clin Nutr 78 (2) : 250-258, 2003.
PubMed
13) Dardevet D, et al : Stimulation of in vitro rat muscle protein synthesis by leucine decreases with age. J Nutr 130 (11) : 2630-2635, 2000.
 
14) Katsanos CS, et al : A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am J Physiol Endocrinol Metab 291 (2) : E381-387, 2006.
PubMed
15) Dickinson JM, et al : Leucine-enriched amino Acid ingestion after resistance exercise prolongs myofibrillar protein synthesis and amino Acid transporter expression in older men. J Nutr 144 (11) : 1694-1702, 2014.
 
16) Bukhari SS, et al : Intake of low-dose leucine-rich essential amino acids stimulates muscle anabolism equivalently to bolus whey protein in older women, at rest and after exercise. Am J Physiol Endocrinol Metab 308 (12) : E1056-1065, 2015.
PubMed
17) Dillon EL, et al : Amino acid supplementation increases lean body mass, basal muscle protein synthesis, and insulin-like growth factor-I expression in older women. J Clin Endocrinol Metab 94 (5) : 1630-1637, 2009.
PubMed
18) Verhoeven S, et al : Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men. Am J Clin Nutr 89 (5) : 1468-1475, 2009.
PubMed
19) Borsheim E, et al : Effect of amino acid supplementation on muscle mass, strength and physical function in elderly. Clin Nutr 27 (2) : 189-195, 2008.
PubMed
20) Kawada S, et al : Resistance exercise combined with essential amino acid supplementation improved walking ability in elderly people. Acta Physiol Hung 100 (3) : 329-339, 2013.
PubMed
21) Kim HK, et al : Effects of exercise and amino acid supplementation on body composition and physical function in community-dwelhng elderly Japanese sarcopenic women : a randomized controlled trial. J Am Geriatr Soc 60 (1) : 16-23, 2012.
PubMed
22) Kim H, et al : Long-term effects of exercise and amino acid supplementation on muscle mass, physical function and falls in community-dwelling elderly Japanese sarcopenic women : A 4-year follow-up study. Geriatr Gerontol Int 16 (2) : 175-181, 2016.
PubMed
P.161 掲載の参考文献
1) Chen LK, et al : Sarcopenia in Asia : consensus report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc 15 : 95-101, 2014.
 
2) Xue QL, et al : Initial Manifestations of Frailty Criteria and the Development of Frailty Phenotype in the Women's Health and Aging Study II. J Gerontol A Bio Sci Med Sci 63 : 984-990, 2008.
 
3) Rizzoli R : Nutrition and sarcopenia. J Clin Densitom 18 : 483-487, 2015.
PubMed
4) Pahor M, et al : Effect of structured physical activity on prevention of major mobility disability in older adults : the LIFE study randomized clinical trial. JAMA 311 : 2387-2396, 2014.
PubMed
5) Visser M, et al : Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia) : the longitudinal aging study Amsterdam. J Clin Endocrinol Metab 88 : 5766-5772, 2003.
 
6) 大澤裕, 他 : サルコペニアに対する新規治療薬の可能性を探る : マイオスタチン阻害薬. サルコペニアとフレイル : 医療職間連携による多角的アプローチ (荒井秀典監修), p202-209. 医薬ジャーナル社, 大阪, 2015.
 
7) Lee WS, et al : Age-associated decrease of type II A/B human skeletal muscle fibers. Clin Orthop Relat Res 450 : 231-237, 2006.
 
8) Pearce SH, et al : Diagnosis and management of vitamin D deficiency. BMJ 340 : b5664, 2010.
PubMed
9) Rondanelli M, et al : Novel insights on nutrient management of sarcopenia in elderly. Biomed Res Int 2015 : 524948, 2015.
PubMed
10) American Geriatrics Society Workgroup on Vitamin D Supplementation for Older Adults : 2013 Recommendations abstracted from the American Geriatrics Society Consensus Statement on Vitamin D for Prevention of FaUs and Their Consequences. J Am Geriatr Soc 62 : 147-152, 2013.
 
11) Miyauchi M, et al : The solar exposure time required for vitamin D3 synthesis in the human body estimated by numerical simulation and observation in Japan. J Nutr Sci Vitaminol (Tokyo) 59 : 257-263, 2013.
PubMed
12) Ceglia L, et al : Vitamin D and its role in skeletal muscle. Calcif Tissue Int 92 : 151-162, 2013.
PubMed
13) Wicherts IS, et al : Vitamin D status predicts physical performance and its decline in older persons. J Clin Endocrinol Metab 92 : 2058-2065, 2007.
 
14) Snij der MB, et al : Vitamin D status in relation to one-year risk of recurrent falling in older men and women. J Clin Endocrinol Metab 91 : 2980-2985, 2006.
 
15) Suzuki T, et al : Low Serum 25-Hydroxyvitamin D Levels Associated With Falls Among Japanese Community-Dwemng Elderly. J Bone Miner Res 23 : 1309-1317, 2008.
PubMed
16) Muir SW, et al : Effect of vitamin D supplemen-tation on muscle strength, gait and balance in older adults : a systematic review and meta-analysis. J Am Geriatr Soc 59 : 2291-2300, 2011.
 
17) Bischoff-Ferrari HA, et al : Fall prevention with supplemental and active forms of vitamin D : a meta-analysis of randomized controlled trials. BMJ 339 : b3692, 2009.
PubMed
18) O'Donnell S, et al : Systematic review of the benefits and harms of calcitriol and alfacalcidol for fractures and falls. J Bone Miner Metab 26 : 531-542, 2008.
 
19) Beaudart C, et al : The effects of vitamin D on skeletal muscle strength, muscle mass and muscle power : a systematic review and meta-analysis of randomized controUed trials. J Clin Endocrinol Metab 99 : 4336-4345, 2014.
 
20) Murad MH, et al : Clinical review : the effect of vitamin D on falls : a systematic review and meta-analysis. J Clin Endocrionol Metab 96 : 2997-3006, 2011.
 
21) Anagnostics P, et al : Sarcopenia in post-menopausal women : Is there any role for vitamin D? Maturitas 82 : 56-64, 2015.
 
22) Bauer JM, et al : Effects of a vitamin D and leucine-enriched whey protein nutritional supplement on measures of sarcopenia in older adults, the PROVIDE study : arandomized, double-blind, placebo-controlled trial. JAMDA 16 : 740-747, 2015.
 
P.169 掲載の参考文献
1) Rosenberg I : Summary comments : epidemiological and methodological problems in determining nutritional status of older persons. Am J Clin Nutr 50 : 1231-1233, 1989.
 
2) Rosenberg IH : Sarcopenia : origins and clinical relevance. J Nutr 127 : 990S-991S, 1997.
PubMed
3) Cruz-Jentoft AJ, et al : Sarcopenia : European consensus on definition and diagnosis : Report of the European Working Group on Sarcopenia in Older People. Age Ageing 39 (4) : 412-423, 2010.
 
4) Kojima M, et al : Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 : 656-660, 1999.
PubMed
5) Kojima M, et al : Ghrelin : Structure and Function. Physiol Rev 85 : 495-522, 2005.
PubMed
6) Nakazato M, et al : A role for ghrelin in the central regulation of feeding. Nature 409 (6817) : 194-198, 2001.
PubMed
7) Arvat E, et al : Preliminary evidence that Ghrelin, the natural GH secretagogue (GHS)-receptor lig-and, strongly stimulates GH secretion in humans. J Endocrinol Invest 23 : 493-495, 2000.
 
8) Wren AM, et al : Gut hormones and appetite control. Gastroenterology 132 : 2116-2130, 2007.
PubMed
9) Date Y, et al : The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology 123 : 1120-1128, 2002.
PubMed
10) Schwartz MW, et al : Central nervous system control of food intake. Nature 404 (6778) : 661-671, 2000.
PubMed
11) Wren AM, et al : Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 86 : 5992, 2001.
PubMed
12) Neary NM, et al : Ghrelin increases energy intake in cancer patients with impaired appetite : acute, randomized, placebo-controlled trial, J Clin Endocrinol Metab 89 : 2832-2836, 2004.
 
13) Akamizu T, et al : Repeated administration of ghrelin to patients with functional dyspepsia : its effects on food intake and apPetite. Eur J Endocrinol 158 : 491-498, 2008.
PubMed
14) 米川忠人, 他 : サルコペニアの診かた (サルコペニアの予防・治療の可能性) 5. グレリン/成長ホルモン/IGF-1にかかわるサルコペニアへの予防・治療 Modern Physician 31 (11) : 1374-1376, 2011.
 
15) Nwokolo CU, et al : Plasma ghrelin following cure of Helicobacter pylori. Gut 52 : 637-640, 2003.
PubMed
16) Kawashima J, et al : Circulating acylated ghrelin level decreases in accordance with the extent of atrophic gastritis. J Gastroenterol 44 : 1046-1054, 2009.
PubMed
17) Jeon TY, et al : Changes in plasma ghrelin concentration immediately after gastrectomy in patients with early gastric cancer. J Clin Endocrinol Metab 89 : 5392-5396, 2004.
PubMed
18) Geloneze B, et al : Ghrelin : agut-brain hormone : effect of gastric bypass surgery. Obes Surg 13 : 17-22, 2003.
 
19) Muller EE, et al : Neuroendocrine control of growth hormone secretion. Physiol Rev 79 (2) : 511-607, 1999.
PubMed
20) Akamizu T, et al : Plasma ghrelin levels in healthy elderly volunteers : the levels of acylated ghrelin in elderly females correlate positively with serum IGF-I levels and bowel movement frequency and negatively with systolic blood pressure. J Endocrinol 188 (2) : 333-344, 2006.
PubMed
21) Serra-Prat M, et al : Relationship between Plasma Ghrelin Levels and Sarcopenia in Elderly Subjects : A Cross-Sectional Study. J Nutr Health Aging 19 (6) : 669-672, 2015.
 
22) Liu H, et al : Systematic review : the safety and ethcacy of growth hormone in the healthy elderly. Ann Intern Med 146 (2) : 104-115, 2007.
PubMed
23) Amitani M, et al : Control of food intake and muscle wasting in cachexia. Int J Biochem Cell Biol 45 (10) : 2179-2185, 2013.
PubMed
24) Inui A : Cancer anorexia-cachexia syndrome : current issues in research and management. CA Cancer J Clin 52 (2) : 72-91, 2002.
PubMed
25) Kodama T, et al : Ghrelin treatment suppresses neutrophil-dominant inflammation in airways of patients with chronic respiratory infection. Pulm Pharmacol Ther 21 (5) : 774-779, 2008.
PubMed
26) Nass R, et al : Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults : a randomized trial. Ann Intern Med 149 (9) : 601-611, 2008.
PubMed
27) Akamizu T, et al : Effects of ghrelin treatment on patients undergoing total hip replacement for osteoarthritis : different outcomes from studies in patients with cardiac and pulmonary cachexia. J Am Geriatr Soc 56 (12) : 2363-2365, 2008.
PubMed
28) Ashitani J, et al : Effect of octanoic acid-rich formula on plasma ghrelin levels in cachectic patients with chronic respiratory disease. Nutr J 8 : 25, 2009.
PubMed
29) 松田邦夫, 他 : 漢方治療のファーストステップ改訂第2版. 南山堂, 東京, 2011.
 
30) Suzuki H, et al : Randomized clinical trial : rikkunshito in the treatment of functional dyspepsia-a multicenter, double-blind, randomized, placebo-controlled study. Neurogastroenterol Motil 26 : 950-961, 2014.
PubMed
31) Takeda H, et al : Rikkunshito and Ghrelin Secretion. Curr Pharm Des 18 : 4827-4838, 2012.
PubMed
32) Takeda H, et al : Rikkunshito, an Herbal Medicine, Suppresses Cisplatin-lnduced Anorexia in Rats Via 5-HT2 Receptor Antagonism. Gastroenterology 134 (7) : 2004-2013, 2008.
 
33) Fujitsuka N, et al : Rikkunshito, a ghrelin protentiator, ameliorates anorexia-cachexia syndrome. Front Pharmacol 5 : 271, 2014.
PubMed
P.178 掲載の参考文献
1) Pedersen BK, et al : Muscle as an endocrine organ : Focus on muscle-derived interleukin-6. Physiol Rev 88 : 1379-1406, 2008.
PubMed
2) Arnold AS, et al : PGC-1 alpha and myokine in the aging muscle. Gerontology 57 : 37-43, 2011.
PubMed
3) Usuki Y, et al : Successful treatment of a senile diabetic woman with cataract with goshajinkigan. Am J Chin Med 19 : 259-263, 1991.
 
4) 大塚敬節 : 漢方診療三十年. 治験例を主とした治療の実際. p314. 創元社, 東京, 1959.
 
5) Takeda T, et al : Pathobiology of the senescence-accelerated mouse (SAM). Exp Gerontol 32 : 117-127, 1997.
PubMed
6) Kishida Y, et al : Go-sha-jinki-Gan (GJG), a traditional Japanese herbal medicine, protects against sarcopenia in senescence-accelerated mice. Phytomedicine 22 : 16-22, 2015.
PubMed
7) Bonaldo P, et al : Cellular and molecular mechanisms of muscle atrophy. Dis Model Mech 6 : 25-39, 2013.
PubMed
8) 中川洋, 他 : 高齢者の腰痛, 下肢通に対するツムラ牛車腎気丸の使用経験. 整外と災外 44 : 219-221, 1995.
 
9) Iwasaki K, et al : A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients. J Clin Psychiatry 66 : 248-252, 2005.
PubMed
10) Tatsumi K, et al : Hochuekkito improves systemic inflammation and nutritional status in elderly patients with chronic obstructive pulmonary disease. J Am Geriatr Soc 57 : 169-170, 2009.
PubMed
11) Sakata Y, et al : Clinical characteristics of elderly patients with proton pump inhibitor-refractory non-erosive reflux disease from the G-PRIDE study who responded to rikkunshito. BMC Gastroenterol 14 : 116, 2014.
 
P.184 掲載の参考文献
1) Glass CK, et al : Combinatorial roles of nuclear receptors in inflammation and immunity. Nat Rev Immunol 6 : 44-55, 2006.
PubMed
2) Adams V, et al : Induction of MuRF1 is essential for TNFα-induced loss of muscle function in mice. J Mol Biol 384 : 48-59, 2008.
 
3) Yakabe M, et al : Clinical manifestations and pathophysiology of sarcopenia. RNA and Transcription 1 : 10-17, 2015.
 
4) Chambon C, et al : Myocytic androgen receptor controls the strength but not the mass of limb muscles. Proc Natl Acad Sci USA 107 : 14327-14332, 2010.
 
5) Orwell E, et al : Endogenous testosterone levels, physical performance, and fall risk in older man. Arch Intern Med 23 : 2124-2131, 2006.
 
6) Bhasin S : Testosterone supplementation for aging-associated sarcopenia. J Gerontol A Biol Sci Med Sci 58 : 1002-1008, 2003.
PubMed
7) Ottenbacher KJ, et al : Androgen treatment and muscle strength in elderly men : A meta-analysis. J Am Geriatr Soc 54 : 1666-1673, 2006.
 
8) Synder PJ, et al : Effect of testosterone treat-ment on body composition and muscle strength in men over 65 years of age. J Clin Endocrinol Metab 84 : 2647-2653, 1999.
 
9) Smith MR, et al : Changes in body composition during androgen deprivation therapy for prostate cancer. J Clin Endocrinol Metab 87 : 599-603, 2002.
PubMed
10) Fukai S, et al : Association of plasma sex hormone levels with functional decline in elderly men and women. Geriatr Gerontol Int 9 : 282-289, 2009.
PubMed
11) Fukai S, et al : Plasma sex hormone levels and mortality in disabled older men and women. Geriatr Gerontol Int 11 : 196-203, 2011.
PubMed
12) Yamada S, et al : Effects of dehydroepiandrosterone supplementationon cognitive function and activities of daily living in older women with mild to moderate cognitive impairment. Geriatr Gerontol Int 10 : 280-287, 2010.
 
13) Akishita M, et al : Effects of physical exercise on plasma concentrations of sex hormones in elderly women with dementia. J Am Geriatr Soc 53 : 1076-1077, 2005.
PubMed
14) Aizawa K, et al : Endurance exercise training enhances local sex steroidogenesis in skeletal muscle. Med Sci Sports Exerc 43 : 2072-2080, 2011.
PubMed
15) Wilhelm-Leen ER, et al : Vitamin D deficiency and frailty in older Americans. J Intern Med 268 : 171-180, 2010.
PubMed
16) Annweiler C, et al : Fall prevention and vitamin D in the elderly : an overview of the key role of the non-bone effects. J Neuroeng Rehabil 7 : 50, 2010.
PubMed
P.192 掲載の参考文献
1) Studenski S, et al : Gait Speed and Survival in Older Adults. JAMA 305 : 50-58, 2011.
PubMed
2) Houston DK, et al : Dietary protein intake is associated with lean mass change in older, community-dwelling adults : the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr 87 : 150-155, 2008.
PubMed
3) Dickinson JM, et al : Exercise and nutrition to target protein synthesis impairments in aging skeletal muscle. Exerc Sport Sci Rev 41 (4) : 216-223, 2013.
PubMed
4) Bruusgaard JC, et al : Myonuclei acquired by overload exercise precede hypertrophy and are not lost on detraining. PNAS 107 (34) : 15111-15116, 2010.
 
5) Hamada T, et al : Enhancement of whole body glucose uptake during and after low frcquency electrical stimulation of human skeletal muscles. J Appl Physiol 94 : 2107-2112, 2003.
 
6) Hasegawa S, et al : Effect of early implementation of electrical muscle stimulation to prevent muscle atrophy and weakness in patients after anterior cruciate ligament reconstruction. J Electromyogr Kinesiol 21 : 622-630, 2011.
PubMed
7) Kimura T, et al : Percutaneous electrical muscle stimulation attenuates postprandial hyperglycemia in obese and pre-obese Japanese men. Int J Sport Health Sci 8 : 1-6, 2010.
 
8) Hamada T, et al : Selective fatigue of fast motor units after electrically elicited muscle contractions. J Electromyogr Kinesiol 14 : 531-538, 2004.
PubMed
9) Miyamoto T, et al : Effect of Percutaneous Electrical Muscle Stimulation on Postprandial Hyperglycemia in Type 2 Diabetes. Diabetes Res Clin Practice 96 : 306-312, 2012.
 
10) Benjamin T : Neuromuscular electrical stimulation increases muscle protein synthesis in elderly type 2 diabetic men. Am J Physiol Endocrinol Metab 303 : E614-E623, 2012.
 
11) Cotman CW, et al : Exercise : a behavioral intervention to enhance brain health and plasticity. Trends Neurosci 25 : 295-301, 2002.
 
12) Gomez-Pinilla F, et al : Brain-derived neurotrophic factor functions as metabotrophin to mediate the effects of exercise on cognition. Eur J Neurosci 28 : 2278-2287, 2008.
PubMed
13) Seifert T, et al : Endurance training enhances BDNF release from the human brain. Am J Physiol Regul Integr Comp Physiol 298 : R372-R377, 2010.
 
14) Ericksona KI, et al : Exercise training increases size of hippocampus and improves memory. PNAS 108 : 3017-3022, 2011.
 
15) Deslandes A, et al : Exercise and Mental Health : Many Reasons to Move. Neuropsychobiology 59 : 191-198, 2009.
PubMed
P.195 掲載の参考文献
1) Graham HN : Prev Med 21 : 334-350, 1992.
PubMed
2) Moore RJ, et al : Br J Nutr 102 : 1790-7802, 2009.
PubMed
3) Dulloo AB, et al : Am J Clin Nutr 70 : 1040-1045, 1999.
 
4) Murase T, et al : Am J Physiol Regul Integr Comp Physiol 295 : R281-E289, 2008.
PubMed
5) Murase T, et al : Am J Physiol Regul Integr Comp Physiol 288 : R708-R715, 2005.
PubMed
6) Kim H, et al : Geratr Gerontol Int 13 : 458-465, 2013.
PubMed

書評

最近チェックした商品履歴

Loading...