Cyto-protection ＆ biology Vol.14 1996年 第14回 サイトプロテクション研究会

出版社： 癌と化学療法社
著者：
発行日： 1996-12-25
分野： 臨床医学：基礎  >  臨床細胞学
ISSN： 0289-368
電子書籍版： 1996-12-25
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1996年　第14回　サイトプロテクション研究会。今回は特別講演１題と研究発表が34台を数えたが、今回はそれらの中でも細胞死、特にアポトーシスに焦点を当てて特別講演とシンポキウムを企画した。

目次

  • 表紙
  • 序文
  • 目次
  • 特別寄稿
  • 血管内皮細胞の機能とその破綻の分子病態
  • 特別講演
  • 司会
  • アポトーシス誘導レセプター分子Fasの生理機能
  • Session 胃I (分泌・血流)
  • 座長
  • 老齢ラットにおける胃粘膜血流の反応性異常と易損性の増大 ―カプサイシン感受性知覚神経の関与―
  • PPIの胃体部粘膜cAMP動態に与える影響
  • Session 胃II (NO・細胞増殖)
  • 座長
  • 培養胃粘膜細胞に対するソルコセリルの作用
  • Session 小腸・大腸
  • 座長
  • ラット消化管粘膜における疎水性の検討
  • ラット小腸虚血再灌流障害における脂質過酸化反応の関与
  • Session 肝I (NO)
  • 座長
  • Nitric oxide産生抑制による大量肝切除後の急性肝障害の対策
  • Session 肝II (虚血・再灌流障害)
  • 座長
  • 肝虚血再灌流におけるNO変動とその意義
  • 肝冷保存・再灌流傷害におけるトロンボキサンA2の好中球接着機序への関与と, その分子機構の解明
  • Session 肝III (代謝)
  • 座長
  • 慢性肝疾患におけるUDCAとグリチルリチン製剤の併用効果について
  • 腎摘除ラットにおけるグルタチオン代謝動態
  • 一酸化炭素を介したcGMP非依存性の毛細胆管収縮調節機構
  • Session 脳・心
  • 座長
  • Calpain inhibitorの虚血再灌流障害に対する心筋保護効果とcalpainの免疫学的検討
  • 脳梗塞再発予防に対する最適抗血小板薬の検討
  • 虚血性脳浮腫に対するarginine vasopressin分泌抑制剤の抗脳浮腫効果
  • Session 悪性腫瘍
  • 座長
  • Topoisomerase IおよびII阻害剤に交叉耐性を有するmerbarone耐性ヒト白血病細胞株CEM/M70-B1細胞の樹立と作用機序の解析
  • ヒト胃炎とコネキシン32の発現
  • Session 活性酸素・NO
  • 座長
  • Catecholamineの白血球機能に対する作用 ―活性化白血球制御の可能性について―
  • 皮弁生着メカニズムにおけるNOの関与
  • O-2産生能からみた敗血症肝障害における脾臓の役割
  • シンポジウム「アポトーシスと病態」
  • 司会
  • 大腸上皮由来interleukin-7 (IL-7) によるアポトーシスを介した粘膜内リンパ球増殖調節機構
  • ラット膵虚血再灌流モデルの作製とアポトーシスの関与
  • 肝および脾マクロファージによる肝類洞内皮細胞apoptosis:nitric oxide(NO)およびtumor necrosis factor (TNF) -αの役割
  • 劇症肝炎モデルにおけるアポトーシスとネクローシスの関与
  • 研究会会則
  • 役員リスト
  • 会告
  • 奥付

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参考文献のリンクは、リンク先の都合等により正しく表示されない場合がありますので、あらかじめご了承下さい。

本参考文献は電子書籍掲載内容を元にしております。

P.10 掲載の参考文献
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特別講演

P.17 掲載の参考文献
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8) Hanabuchi S, Koyanagi M, Kawasaki A, et al:Fas and its Iigand in a general mechanism of T-cell-mediated cytotoxicity. Proc. Natl. Acad. Sci. USA 91:4930-4934, 1994.
 
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10) Kojima H, Shinohara N, Hanaoka S, et al:Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes. Immunity. 1:357-364, 1994.
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11) Ogasawara J, Watanabe-Fukunaga R, Adachi M, et al:Lethal effect of the anti-Fas antibody in mice. Nature 364:806-809, 1993.
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12) Takahashi T, Tanaka M, Brannan CI, et al:Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76:969-976, 1994.
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13) Boldin MP, Varfolomeev EE, Pancer Z, et al:A novel protein that interacts with the death domain of Fas/APO-lcontains a sequence motif related to the death domain. J. Biol. Chem. 270:7795-7798, 1995.
 
14) Chinnaiyan AM, 0, Rourke K, Tewari M, et al:FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81:505-512, 1995.
 
15) Boldin MP, Goncharov TM, Goltsev YV, et al:Involvement of MACH, a Novel MORTI/FADD-Interacting Protease, in Fas/APO-1-and TNF Receptor-Induced Cell Death. Cell 85:803-815, 1996.
 
16) Muzio M, Chinnaiyan AM, Kischkel FC, et al:FLICE, A Novel FADD Homologous ICE/CED-3 like Protease, Is Recruited to the CD95 (Fas/Apo-1) Death-Inducing Signaling Complex. Cell 85:817-827, 1996.
 
P.22 掲載の参考文献
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2) Miyake H, Kato S and Takeuchi K:Increased susceptibility of rat gastric mucosa to ulcerogenic stimulation with aging:Role of capsaicin-sensitive sensory neurons. Dig. Dis. Sci. 41:339-345, 1996.
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3) Matsumoto J, Takeuchi K, Ueshima K, et al:Role of capsaicin-sensitive afferent neurons in mucosal blood flow response of rat stomach induced by mild irritants. Dig. Dis. Sci. 37:1336-1334, 1992.
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4) Takeuchi K, Ohuchi T, Narita S, et al:Capsaicin-sensitive sensory nerves in recovery of gastric mucosal integrity after damage by sodium taurocholate in rats. Jpn. , J. Pharmacol. 63:479-486, 1993.
 
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6) Li DS, Raybould HE, Quintero E, et al:Calcitonin gene-related peptide mediates the gastric hypermic response to acid back diffusion. Gastroenterology 102:1124-1128, 1992.
 
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P.25 掲載の参考文献
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Session 胃II (NO・細胞増殖)

P.30 掲載の参考文献
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P.33 掲載の参考文献
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2) Mack DR, et al:Surface hydrophobicity of the intestinal tract. Am. J. PhvsioL 262:G171-G177, 1992.
 
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4) Goggin PM, et al:Molecular Basis for gastric mucosal hydrophobicity. Gastroetiterology 98:A49, 1990.
 
5) Butler BD. et al:Distribution of surfactants in the canine GI tract and their ability to lubricate. Am. J. Phvsiol. 244:G645-G651, 1983.
 
P.36 掲載の参考文献
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3) Granger D:Role of xanthine oxidase and grannulocytes in ischemia-reperfusion injury. Am. J. PhysioL 255:H1269-H1275, 1988.
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4) Otamiri T:Oxygen radicals, lipid peroxidation, and neutrophil infiltration after small-intestinal ischemia and reperfusion. Surgery 105:593-597, 1989.
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10) Keelan M, Thomson A, Clandin M, et al:Effect of oral enprostil, a synthetic prostagrandin E2, on intestinal brush border membrane lipid composition following abdominal irradiation in the rat. Clin. Invest. Med. 12:350-356, 1989.
 
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13) 横出正之:動脈硬化-分子機構と内皮細胞のか かわり-. 血管と内皮 5:222-227, 1995.
 

Session 肝I (NO)

P.41 掲載の参考文献
1) Brown JF, Tepperman BL, Hanson PJ, et al:Differential distribution of nitric oxide synthase between cell fractions isolated from the rat gastric mucosa. Biochem. Biophys. Res. Commun. 184:680-685, 1992.
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2) Mochida S, Ogata 1, Hirata K, et al:Provocation of Massive Hepatic Necrosis by Endotoxin After Partial Hepatectomy in Rats. Gastroenterology 99:771-777, 1990.
 
3) Fujiwara K, Ogata I, Mochida S, et al:Activated Kupffer Cells as a Factor of Massive Hepatic Necrosis after Liver Resection. Hepato8astroenterology 37:194-197, 1990.
PubMed
4) Obolenskaya M, Vanin AF, Mulsch A, et al:Eprevidence of Nitric Oxide Production by the Regenerating Rat Liver. Biochem. Biophys. Res. Commun. 202:571-576, 1994.
 
5) Hortelano S, Dewez B, Genaro AM, et al:Nitric Oxide is Released in Regenerating Liver After Partial Hepatectomy. Hερarology 21:776-786, 1995.
 
P.46 掲載の参考文献
1) 戸田 昇, 中根正樹, 木村 宏. ・他:NO (戸田 昇・編), 第1版, メジカルビュー社, 東京, 1995, pp. 14-27.
 
2) Griffiths MJD, Messent M, MacAllister RJ, et al:Aminoguanidine selectively inhibits inducible nitric oxide synthase. Br. J. Pharmacol. 110:963-968,
 
3) Tong TMA, Harry I and Clifford AB:Endotoxin-Stimulated Nitric Oxide Production Increases Injury and Reduces Rat Liver Chemiluminescence During Reperfusion. Gastroenterology 108:463-469, 1995.
 
P.49 掲載の参考文献
1) Ishiguro S, Arii S, Monden K, et al:Involvement of Thromboxane A2-Thromboxane A2 receptor system of the hepatic sinusoid in pathogenesis of cold preservation/reperfusion injury in the rat liver graft. Transplantation 59 (7):957-961, 1995.
PubMed
2) Enger RL, Schmid-Shoubein GW and Pavelec RS:Leukocyte capillary plugging in myocardial ischemia and reperfusion in the dog. Am. J. Pathol. 111:98-111, 1983.
 
3) Linas SL, Shanley PF, Whittenburg D, et al:Neutrophils accentuate ischemia-reperfusion injury in isolated perfused rat kidneys. Am. J. Physiol. 255:F728-F735, 1987.
 
4) Hemandez LA, Grisham MB, Twohig B, et al:Role of neutrophils in ischemia-reperfusion induced microvascular injury. Am. J. Physiol. 253:H699-H703, 1987.
 
5) Albertine KH, Weyrich AS, Ma Xl, et al:Quantification of neutrophil migration following myocardial ischemia and reperfusion in cats and dogs. J. Leuko. Bio. 55:557-566, 1994.
 

Session 肝III (代謝)

P.53 掲載の参考文献
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3) 中村公英, 青島 優, 谷 光憲・他:代償性肝 硬変症に対するウルソデオキシコール酸 (UDCA) の治療効果と血中胆汁酸代謝に及ぼ す影響. 日消誌 89:2762-2770, 1992.
 
4) 美馬聡昭, 関谷千尋, 金川博史・他:自己免疫 性肝炎におけるウルソデオキシコール酸の効 果. 肝臓 34:849-850, 1993.
 
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Session 脳・心

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Session 活性酸素・NO

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