アレルギー炎症性疾患―新たなアプローチ―

出版社： 先端医学社
著者：
発行日： 1994-11-25
分野： 臨床医学：内科  >  アレルギー
ISBN： 9784915892158
電子書籍版： 1994-11-25 （第1版第1刷）
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アレルギー性炎症性疾患の基礎を踏まえ、気管支喘息・アトピー性皮膚炎・鼻アレルギーを具体的に解説。“アレルギー炎症性疾患”の基礎を踏まえたうえで、従来“アトピー性疾患”と考えられてきた気管支喘息、アトピー性皮膚炎、鼻アレルギーがなぜ“アレルギー性炎症性疾患”と理解されるべきであるのかを明らかにすることを目的とした一冊。アレルギー炎症の研究者、アレルギー性炎症性疾患に携わる臨床医の必読の書。

目次

  • 表紙
  • 序
  • 執筆者一覧
  • 略語一覧
  • 目次
  • I アレルギー炎症 - 研究の進歩 -
  • 1. 概念の整理
  • はじめに
  • [1] 炎症研究の歴史
  • [2] 炎症反応
  • [3] アレルギー研究の歴史
  • [4] アレルギー反応
  • [5] IgE - 肥満細胞を介するアレルギー反応に関する従来の考え方
  • [6] IgE - 肥満細胞を介するアレルギー反応における炎症的要素の導入
  • [7] アレルギー炎症
  • おわりに
  • 2. IgE抗体産生および作用の制御
  • はじめに
  • [1] Th細胞のサブセット
  • [2] IgE産生の誘導機序
  • [3] ジャームラインCεmRNAとIgEクラススイッチ
  • [4] IgE産生の調節に関与するサイトカイン
  • A. 正の調節活性を示すサイトカイン
  • B. 負の調節活性を示すサイトカイン
  • おわりに
  • 3. 肥満細胞からのヒスタミン遊離機構 - 新たな展開 -
  • はじめに
  • [1] 肥満細胞の細胞膜における情報認識
  • A. ヒスタミン遊離を惹起させる情報の認識
  • B. ヒスタミン遊離を抑制する情報の認識
  • [2] 細胞膜を介した細胞内への情報伝達
  • A. 細胞内へのカルシウムイオン流入
  • B. 細胞内Ca storeからのカルシウムイオン遊離
  • C. 細胞膜蛋白の側方移動
  • [3] 細胞内の情報伝達
  • A. ヒスタミン遊離に促進的な因子
  • B. ヒスタミン遊離抑制に関与する因子
  • [4] 顆粒放出系の駆動
  • [5] 顆粒からのヒスタミン遊離
  • おわりに
  • 4. Th1, Th2細胞とサイトカイン
  • はじめに
  • [1] アレルギー反応を誘導する免疫応答
  • [2] Th1, Th2細胞の分化誘導
  • [3] サイトカインによるIgE産生の促進と調節
  • [4] アレルギー反応における炎症反応
  • [5] 炎症細胞の分化を誘導するサイトカインとアレルギー反応における炎症
  • おわりに
  • 5. 炎症細胞の接着と遊走
  • はじめに
  • [1] 細胞接着分子と細胞浸潤
  • [2] 好酸球の血管内皮細胞への接着
  • A. 実験方法
  • B. インターロイキン - 1による好酸球の接着
  • C. インターロイキン - 4による好酸球の接着
  • [3] 好酸球の内皮細胞を超える遊走
  • A. 実験方法
  • B. 細胞接着分子による好酸球遊走の抑制
  • C. サイトカインによるtransmigrationの増強効果
  • [4] 好酸球遊走とサイトカイン・ケモカイン
  • A. サイトカインの好酸球遊走に与える影響
  • B. ケモカインの好酸球遊走に与える影響
  • おわりに
  • II 気管支喘息
  • 1. 肥満細胞・T細胞と気管支喘息
  • はじめに
  • [1] 粘膜炎症を呈する気管支喘息の研究法
  • [2] 即時型アレルギー反応における肥満細胞
  • [3] 慢性アレルギー炎症における肥満細胞
  • A. 気管支粘膜の免疫組織化学染色
  • B. 単離したヒト肥満細胞の免疫組織化学染色とサイトカイン産生
  • C. ヒト肥満細胞におけるサイトカイン遺伝子発現
  • [4] 気管支喘息における活性化CD4 T細胞
  • A. 活性化CD4 T細胞よりのサイトカイン産生
  • おわりに
  • 2. 好酸球と気道過敏性 - 好酸球性肺炎との比較を中心に -
  • はじめに
  • [1] アレルギー性肺疾患としての気管支喘息
  • [2] 気管支喘息と好酸球
  • [3] 喘息・アレルギー病変で出現するhypodense eosinophil ( hypo Eo ) の特徴
  • [4] 好酸球性肺炎と気道過敏性
  • おわりに
  • 3. 好塩基球と気管支喘息
  • はじめに
  • [1] 好塩基球の機能
  • [2] 好塩基球の表面構造
  • A. 免疫グロブリンレセプター
  • B. 走化性因子レセプター
  • C. 補体成分レセプター
  • D. サイトカインレセプター
  • E. 接着分子
  • F. CD40リガンド
  • [3] 遅発相反応と好塩基球
  • [4] 気管支喘息患者気道の好塩基球
  • [5] 気管支喘息と好塩基球
  • おわりに
  • 4. ケミカルメディエーター - レセプターと気道に対する作用 -
  • はじめに
  • [1] ヒスタミン
  • A. ヒスタミンレセプター
  • B. 気道に対する作用
  • C. 喘息における役割
  • [2] プロスタノイド
  • A. プロスタノイドレセプター
  • B. 気道に対する作用
  • C. 喘息における役割
  • [3] ロイコトリエン
  • A. ロイコトリエンレセプター
  • B. 気道に対する作用
  • C. 喘息における役割
  • [4] 血小板活性化因子
  • A. PAFレセプター
  • B. 気道に対する作用
  • C. 喘息における役割
  • おわりに
  • 5. ヒスタミン遊離因子と慢性気道炎症
  • はじめに
  • [1] 炎症細胞由来ヒスタミン遊離因子
  • [2] ヒスタミン遊離因子の産生
  • [3] ヒスタミン遊離因子の作用の特徴
  • [4] ヒスタミン遊離因子の精製
  • [5] ヒスタミン遊離因子と疾患
  • おわりに
  • 6. 慢性気道炎症とエンドセリン
  • はじめに
  • [1] エンドセリンについて
  • [2] 気道とエンドセリンについて
  • [3] 肺肥満細胞とエンドセリンについて
  • [4] サイトカインとエンドセリンについて
  • [5] 好酸球とエンドセリンについて
  • おわりに
  • 7. ニューロペプチドと気管支喘息
  • はじめに
  • [1] 自律神経とニューロペプチド
  • [2] 喘息とニューロペプチド
  • A. VIPとPHI
  • B. 知覚ニューロペプチド
  • C. ニューロペプチドY
  • D. ガラニン
  • E. その他のニューロペプチド
  • [3] 気道上皮細胞傷害と気道過敏性
  • おわりに
  • 8. 気道過敏性とサイトカイン
  • はじめに
  • [1] サイトカインとアレルギー炎症
  • [2] 気道過敏性
  • A. インターロイキン - 5
  • B. インターロイキン - 1
  • C. インターロイキン - 2
  • D. 腫瘍壊死因子 - α
  • おわりに
  • 9. 慢性気道炎症と接着分子
  • はじめに
  • [1] 炎症細胞の組織移行に関与する接着分子群
  • A. セレクチンファミリー
  • B. 免疫グロブリンスーパーファミリー
  • C. インテグリンファミリー
  • [2] 白血球の組織移行機序と接着分子
  • [3] 好中球の組織移行と接着分子
  • [4] 好酸球の組織移行と接着分子
  • [5] 気道上皮細胞に発現する接着分子
  • [6] 慢性気道炎症とサイトカイン発現の特異性
  • おわりに
  • 10. 慢性気道炎症と気道上皮細胞 - リモデリングを含めて -
  • はじめに
  • [1] 気管支喘息でみられる形態学的変化
  • [2] 気道損傷と気道過敏性
  • A. 気道上皮細胞由来の拡張性物質
  • B. 気道上皮細胞由来の収縮性物質
  • C. 気道上皮細胞のニュートラルエンドペプチダーゼ
  • D. 気道上皮細胞の透過性亢進
  • [3] 気道損傷とその修復, リモデリング
  • A. 上皮基底膜層の変化
  • B. 腺上皮の増殖
  • C. 気道上皮細胞の再生修復機構
  • [4] 気道上皮細胞から産生される活性因子
  • A. インターロイキン - 6
  • B. インターロイキン - 8
  • C. 顆粒球・マクロファージコロニー刺激因子
  • D. その他
  • [5] アレルギー性気道炎症における気道上皮細胞
  • [6] 気道上皮細胞のサイトカイン産生能と喘息治療薬の影響
  • おわりに
  • 11. 慢性気道炎症と気道分泌
  • はじめに
  • [1] 気道分泌細胞
  • [2] 気道分泌亢道の機序
  • A. ムチン分泌
  • B. 水分分泌
  • C. 浸出液
  • [3] 気管支喘息の気道分泌物および喀痰
  • [4] 気道内粘液貯留
  • [5] 気道分泌と気道過敏性
  • [6] ステロイド剤の気道分泌抑制作用
  • おわりに
  • 12. 大気汚染と気道上皮細胞
  • はじめに
  • A. 大気汚染物質によるアジュバント作用
  • B. 大気汚染物質と気道炎症に関する最近の話題
  • C. 目的
  • [1] ヒト気道上皮細胞から産生されるサイトカイン
  • A. ヒト気道上皮細胞の無血清培養法
  • [2] ヒト気道上皮細胞に及ぼす大気汚染物質の影響 ( 結果および考察 )
  • A. 浮遊粒子状物質
  • B. ディーゼルエンジン排出微粒子
  • C. 五酸化バナジウム ( V2O5 )
  • [3] まとめおよび考察
  • おわりに
  • 13. アトピー性気管支喘息の遺伝
  • はじめに
  • [1] 気管支喘息の遺伝
  • [2] アトピーの遺伝
  • [3] アトピー素因に関するオックスフォード大学グループの報告
  • [4] われわれの検討結果
  • [5] 気道過敏性の遺伝
  • おわりに
  • 14. ヒスタミン産生酵素および分解酵素遺伝子の発現調節と気管支喘息
  • はじめに
  • [1] ヒスタミン代謝
  • [2] ヒスチジン脱炭酸酵素
  • [3] ヒスタミンN - メチル基転移酵素
  • [4] 気道系におけるヒスタミン代謝
  • [5] 気管支喘息の病態とヒスタミン代謝
  • おわりに
  • 15. 気管支喘息における慢性気道炎症病態制御へのアプローチ
  • はじめに
  • [1] 慢性気道炎症としての喘息
  • [2] 抗アレルギー薬の現況
  • [3] 喘息とステロイド剤
  • [4] 喘息の治療的アプローチ
  • おわりに
  • III アトピー性皮膚炎
  • 1. 肥満細胞とアトピー性皮膚炎
  • はじめに
  • [1] ヒト皮膚由来真皮肥満細胞
  • A. 形態
  • B. 機能
  • C. 皮膚肥満細胞とアトピー性皮膚炎 ( アレルギー・炎症の視点から )
  • おわりに
  • 2. T細胞とアトピー性皮膚炎
  • はじめに
  • [1] 浸潤細胞のプロフィール
  • [2] サイトカイン産生プロフィールからみたT細胞
  • [3] 細菌由来スーパー抗原とT細胞
  • [4] T細胞と接着分子
  • おわりに
  • 3. 好酸球とアトピー性皮膚炎
  • はじめに
  • [1] 好酸球の細胞生物学
  • A. 好酸球の分化・増殖
  • B. 末梢血好酸球の動態
  • C. 組織内浸潤好酸球の動態
  • [2] アトピー性皮膚炎における好酸球の動態
  • A. 末梢血好酸球増多
  • B. 好酸球出現率の増加
  • C. ECP値の上昇
  • D. in vitroにおけるサイトカインおよび免疫複合体に対するAD好酸球の反応性
  • [3] アトピー性皮膚炎における好酸球の役割
  • [4] 治療への展望
  • おわりに
  • 4. ランゲルハンス細胞とアトピー性皮膚炎
  • はじめに
  • [1] ランゲルハンス細胞の起源
  • [2] ランゲルハンス細胞の遊走
  • [3] ランゲルハンス細胞の成熟, 分化
  • [4] ランゲルハンス細胞の接着分子
  • [5] ランゲルハンス細胞のマーカー
  • [6] ランゲルハンス細胞のレセプター
  • [7] ランゲルハンス細胞の産生するサイトカイン, メディエーター
  • [8] ヘルパーT ( Th ) 2細胞とランゲルハンス細胞
  • [9] ランゲルハンス細胞の機能に影響を与える因子
  • おわりに
  • 5. 表皮細胞の関与
  • はじめに
  • [1] アトピー性皮膚炎と黄色ブドウ球菌について
  • [2] 角層の役割
  • [3] 黄色ブドウ球菌特異的IgE産生
  • [4] 細胞性免疫と液性免疫
  • [5] アトピー性皮膚炎とトキシン産性株
  • [6] 皮膚局所におけるサイトカイン産生
  • おわりに
  • 6. 局所メディエーターとその作用
  • はじめに
  • [1] 皮膚I型アレルギー反応におけるメディエーター
  • A. ヒスタミン
  • B. アラキドン酸代謝産物
  • C. 血小板活性化因子
  • D. その他
  • [2] アトピー性皮膚炎の組織像について
  • [3] 皮膚I型アレルギー反応における炎症細胞の浸潤機序
  • [4] アトピー性皮膚炎における局所メディエーター
  • おわりに
  • 7. 活性酸素とアトピー性皮膚炎
  • はじめに
  • [1] O2 - ・ + O2 - ・ + 2H + → O2 + H2O2
  • [2] 皮膚と活性酸素
  • [3] アトピー性皮膚炎とスーパーオキシドジスムターゼ
  • おわりに
  • 8. ニューロペプチドとアトピー性皮膚炎
  • はじめに
  • [1] ヒト皮膚におけるニューロペプチドの分布と共存
  • [2] ニューロペプチド, おもにサブスタンスPの機能
  • [3] アトピー性皮膚炎におけるニューロペプチドの役割
  • おわりに
  • 9. サイトカインとアトピー性皮膚炎
  • はじめに
  • [1] Th1細胞, Th2細胞とそのサイトサイン
  • [2] アトピー性皮膚炎患者におけるTh2様細胞
  • [3] アトピー性皮膚炎皮膚病変部におけるTh2様細胞
  • [4] サイトカインによるアトピー性皮膚炎の治療
  • [5] サイトカインの異常から推定されるアトピー性皮膚炎の臨床的特徴
  • おわりに
  • 10. 接着分子とアトピー性皮膚炎
  • はじめに
  • [1] 接触皮膚炎の発症における細肋接着分子の関与
  • [2] 接触皮膚炎とアトピー性皮膚炎との違い
  • [3] アトピー性皮膚炎病変部に存在するT細胞
  • おわりに
  • 11. アトピー性皮膚炎における湿疹反応
  • はじめに
  • [1] アトピー性皮膚炎の臨床像
  • [2] アトピー性皮膚炎の皮膚病変形成におけるアレルギー性機序
  • A. I型アレルギー
  • B. II型アレルギー
  • C. III型アレルギー
  • D. IV型アレルギー細胞性免疫型
  • [3] アトピー性皮膚炎患者におけるダニパッチテスト
  • [4] マウスモデルにおけるIgE依存性湿疹反応
  • [5] アトピー性皮膚炎における病変形成のメカニズム
  • [6] アトピー性皮膚炎の重症化因子
  • おわりに
  • 12. 生活環境とアトピー性皮膚炎
  • はじめに
  • [1] ダニについて
  • A. ダニの生態
  • B. ダニ抗原とアトピー性皮膚炎
  • C. ダニ抗原の関与するアトピーの多様性
  • D. ダニ除去治療に対する反応の多様性
  • E. ダニ抗原の除去の臨床的意義
  • F. ダニ抗原の除去の実際
  • G. ダニ抗原の定量
  • H. ヒトの側の問題
  • [2] カビについて
  • [3] 花粉について
  • [4] ホルマリンについて
  • [5] その他
  • おわりに
  • 13. アトピー性皮膚炎と遺伝
  • はじめに
  • [1] 双生児研究法を応用した病気発症に関与する遺伝要因
  • [2] 遺伝標識との相関を指標にする解析
  • [3] 発症年齢分布を応用した疾患の均質性の解析
  • [4] 抗原特異的IgE免疫応答の遺伝子支配
  • [5] 抗原非特異的IgE免疫応答の遺伝子支配
  • [6] IgEレセプター遺伝子
  • [7] 皮表脂質の遺伝
  • [8] アトピー性皮膚炎発症を支配する遺伝子群
  • A. IgE免疫応答の遺伝子支配
  • B. 皮脂の遺伝子支配
  • C. その他
  • おわりに
  • 14. アトピー性皮膚炎制御へのアプローチ
  • はじめに
  • [1] アレルギー発症からみたアトピー性皮膚炎
  • [2] アレルギー炎症制御によるアトピー性皮膚炎治療へのアプローチ
  • A. ステロイド剤
  • B. 抗アレルギー薬
  • C. その他の薬剤
  • おわりに
  • IV 鼻アレルギー
  • 1. 肥満細胞と鼻アレルギー
  • はじめに
  • [1] 鼻アレルギー鼻粘膜肥満細胞の分布と多様性
  • [2] 鼻アレルギー鼻粘膜肥満細胞と電顕所見, アレルギー反応との関係
  • [3] 鼻アレルギー鼻粘膜肥満細胞とサイトカイン
  • おわりに
  • 2. T細胞・好酸球と鼻アレルギー
  • はじめに
  • [1] 抗原誘発により惹起された鼻アレルギー
  • A. 鼻汁中の炎症細胞
  • B. 鼻粘膜中の炎症細胞浸潤
  • C. 鼻粘膜遅発相におけるTh2タイプサイトカインmRNAの発現
  • D. Th2タイプのサイトカインのmRNAを発現する細胞はT細胞がメインか ?
  • [2] 局所ステロイド剤による炎症細胞浸潤とサイトカイン産生の制御
  • おわりに
  • 3. 局所メディエーターとその作用
  • はじめに
  • [1] 鼻アレルギーにおける即時型反応, 遅発型反応の成立機序
  • [2] 鼻粘膜過敏性と局所メディエーター
  • [3] 鼻粘膜における好酸球浸潤, 脱顆粒
  • [4] 鼻粘膜過敏性の成立機序
  • おわりに
  • 4. ニューロペプチドと鼻アレルギー
  • はじめに
  • [1] ニューロペプチドの生理
  • [2] タキキニン
  • [3] カルシトニン遺伝子関連ペプチド
  • [4] ガストリン放出ペプチド
  • [5] 血管作動性腸管ペプチド
  • [6] peptide with histidine at the N - terminal and methionine at the C - terminal ( PHM )
  • [7] ニューロペプチドY
  • [8] ブラジキニン
  • [9] エンドセリン - 1
  • [10] ニュートラルエンドペプチダーゼ
  • [11] アンギオテンシン変換酵素
  • [12] カルボキシペプチダーゼN
  • [13] アミノペプチダーゼM
  • おわりに
  • 5. サイトカインと鼻アレルギー
  • はじめに
  • [1] 鼻アレルギー鼻粘膜におけるサイトカインの発現
  • [2] 好酸球の浸潤, 機能とサイトカイン
  • [3] 細胞接着分子とサイトカイン
  • [4] サイトカイン作用の制御
  • おわりに
  • 6. 接着分子と鼻アレルギー
  • はじめに
  • [1] 鼻アレルギーにおける細胞浸潤
  • [2] 鼻粘膜における細胞接着分子の発現
  • [3] 抗原投与後の細胞接着分子, サイトカインの動態
  • [4] 他の鼻科学領域の慢性炎症疾患における接着分子, サイトカインの発現
  • [5] 気道感染ウイルスによる鼻粘膜での細胞接着分子の発現
  • おわりに
  • 7. 鼻粘膜上皮細胞と鼻アレルギー
  • はじめに
  • [1] 鼻粘膜粘液上皮細胞層中の好塩基球性細胞 / 好酸球分化増殖因子
  • [2] 鼻粘膜上皮細胞培養上清中の肥満細胞, 好塩基球, 好酸球分化増殖因子
  • A. 鼻粘膜上皮細胞数と好基球性細胞 / 好酸球分化増殖因子
  • B. 標的細胞培養期間と分化増殖因子の出現
  • C. 鼻粘膜上皮細胞の増殖と分化増殖因子
  • D. 鼻粘膜上皮細胞の増殖と肥満細胞の分布
  • [3] 鼻粘膜上皮細胞培養上清中のサイトカイン
  • A. 単球 / マクロファージの集積
  • B. 好塩基球性細胞 / 好酸球の集積
  • C. 鼻粘膜上皮細胞数とサイトカイン産生
  • D. 鼻粘膜上皮細胞の増殖とサイトカインの産生
  • E. 鼻粘膜上皮細胞内のサイトカインの分布
  • F. 鼻粘膜上皮細胞由来のサイトカインとステロイド剤
  • おわりに
  • 8. アレルギー性副鼻腔炎
  • はじめに
  • [1] アレルギー性副鼻腔炎のX線写真の特徴
  • [2] アレルギー性副鼻腔炎の病理組織
  • [3] 上顎洞粘膜の抗原誘発反応
  • [4] 粘膜浸潤好酸球の特徴
  • [5] アレルギー性副鼻腔炎の臨床像
  • [6] アレルギー性副鼻腔炎に対する治療
  • おわりに
  • 9. 大気汚染と鼻アレルギー
  • はじめに
  • [1] 疫学調査の結果
  • [2] 大気汚染の推移
  • [3] 実験動物を用いた大気汚染が花粉症様病態に及ぼす影響に関する研究
  • [4] ディーゼル排出微粒子が鼻粘膜の反応性に及ぼす影響
  • A. 目的
  • B. 方法
  • C. 結果
  • D. 考察
  • おわりに
  • 10. 鼻アレルギーと遺伝
  • はじめに
  • [1] 鼻アレルギーの遺伝学的解析
  • [2] スギ花粉アレルギーの遺伝学的解析
  • [3] HLAクラスII分子によるT細胞へのアレルゲンペプチドの提示
  • [4] T細胞のアレルギーへの寄与
  • [5] IgE応答の遺伝要因
  • おわりに
  • 11. 鼻アレルギー制御へのアプローチ
  • はじめに
  • [1] 鼻アレルギーの発症機序とアレルギー治療の泰効機序
  • [2] アレルギーの治療
  • A. 抗原回避
  • B. 特異的免疫療法 ( 抗原特異的減感作療法 )
  • C. 薬物療法
  • D. 手術
  • [3] 治療法の選択
  • A. 成人の通年性鼻アレルギー
  • B. 成人の花粉症
  • C. 小児の鼻アレルギー
  • [4] 将来の展望
  • A. IgE抗体産生抑制
  • B. 皮下注射以外の経路による減感作療法
  • C. レセプターに対する拮抗薬
  • おわりに
  • 索引
  • 奥付
  • 正誤表

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本参考文献は電子書籍掲載内容を元にしております。

I アレルギー炎症 - 研究の進歩 -

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II 気管支喘息

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IV 鼻アレルギー

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