眼瞼けいれん診療ガイドライン 第2版(2022)

出版社： 日本神経眼科学会
著者：
発行日： 2022-12-15
分野： 臨床医学：外科  >  眼科学
ISBN： 9784900611408
電子書籍版： 2022-12-15 （第2版第1刷）
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眼瞼けいれん診療ガイドライン 第2版(2022)

目次

  • 表紙
  • 序論
  • 眼瞼けいれん診療ガイドライン第2版 ( 2022 ) について
  • 眼瞼けいれん診療ガイドライン第2版 ( 2022 ) 眼瞼けいれんガイドライン改定委員会
  • 目次
  • A 全体像・概念
  • CQ1 眼瞼けいれんの定義はどのようなものですか
  • CQ2 眼瞼けいれんの歴史はどのように変遷していますか
  • CQ3 眼瞼けいれんでみられる症状はどのようなものですか
  • CQ4 眼瞼けいれんはどのように分類されますか
  • CQ5 眼瞼けいれんの頻度、有病率はどうなっていますか
  • CQ6 本態性眼瞼けいれんの原因は何ですか
  • CQ7 薬剤性眼瞼けいれんの原因は何ですか
  • CQ8 症候性眼瞼けいれんの原因は何ですか
  • CQ9 眼瞼けいれんの自然経過はどうなりますか
  • CQ10 眼瞼けいれんの症状の3要素とは何ですか
  • CQ11 メージュ症候群と眼瞼けいれんは同じですか
  • CQ12 眼瞼けいれんは遺伝しますか
  • CQ13 眼瞼けいれんかもしれないと思った場合、どういった医療機関を受診すれば良いですか
  • B 診断・検査・鑑別・合併症
  • CQ14 眼瞼けいれんはどのように診断すればよいですか
  • CQ15 着明や疹痛が主で、眼部のジストニアが目立たない症例でも眼瞼けいれんですか
  • CQ16 重症度はどのように判定しますか
  • CQ17 行なうべき検査とその評価はどうしますか
  • CQ18 鑑別すべき疾患は何ですか
  • CQ19 眼瞼けいれんと重症筋無力症の関係を教えてください
  • CQ20 眼瞼けいれんに合併しやすいまたは、眼瞼けいれんを合併しやすい疾患にはどのようなものがありますか
  • C 症状・徴候・危険因子
  • CQ21 眼瞼けいれんにおける瞬目異常とはどういうものですか
  • CQ22 眼瞼けいれんと着明、光過敏との関係はありますか
  • CQ23 眼瞼けいれんでは痛みがありますか
  • CQ24 眼瞼けいれんにおいて精神症状のかかわりはありますか
  • CQ25 眼瞼けいれんが眼科手術やその他の身体手術を契機に発症することはありますか
  • CQ26 眼瞼けいれんに眼瞼下垂手術したらどうなりますか
  • CQ27 眼瞼けいれんとベンゾジアゼピン系睡眠薬は関係ありますか
  • CQ28 眼瞼けいれんの発症や増悪、完解に関与する因子はありますか
  • CQ29 原因となる疾患が悪化すると症候性眼瞼けいれんは悪化するのでしょうか
  • CQ30 眼瞼けいれんはどのような人に発症しやすいですか
  • CQ31 本態性眼瞼けいれんの発症を予防することはできますか
  • CQ32 眼瞼けいれんと開瞼失行の関係と治療についてを教えてください
  • CQ33 眼瞼けいれんで、他の局所ジストニアが併存する場合がありますか
  • D メカニズム・研究
  • CQ34 眼瞼けいれんの脳機能画像の検討は行われていますか
  • CQ35 眼瞼けいれんでは差明などの感覚過敏があるといわれますが, なぜそうなるのですか
  • CQ36 眼瞼けいれんで左右差が生じることがありますか 治療はどのようにするのでしょうか
  • CQ37 眼瞼けいれんにおいて、心理学的、精神医学的関連はありますか
  • E ドライアイ関連
  • CQ38 眼瞼けいれんがよくドライアイと診断されるのはなぜですか
  • CQ39 眼瞼けいれんにおいて、ドライアイの治療は意味がありますか
  • F 治療
  • CQ40 眼瞼けいれんの治療の第一選択はボツリヌス治療ですか
  • CQ41 ボツリヌス注射以外に治療はありますか
  • CQ42 ボツリヌス治療の効果と限界を教えてください
  • CQ43 ボトックス注射を開始するときの説明としてどのような点に注意を払いますか
  • CQ44 眼瞼けいれんにおけるボツリヌス注射治療において、麻酔、注射法、注射部位、回数や間隔などによって効果が変わりますか
  • CQ45 ボツリヌス治療の副作用と対処法を教えてください
  • CQ46 本態性以外の眼瞼けいれんにもボツリヌス療法が有効なのでしょうか
  • CQ47 眼瞼以外に口舌や鼻周囲にも不随意運動が見られますがどう治療したらよいでしょうか
  • CQ48 眼瞼けいれんのボツリヌス注射が痛いのはどうにかできませんか
  • CQ49 眼瞼けいれんの薬物治療 ( ボツリヌス治療以外 ) にはどのようなものがあり、どう位置付けられますか
  • CQ50 眼瞼けいれんに点眼治療は有効でしょうか
  • CQ51 眼瞼けいれんにおける眼瞼手術にはどんなものがありますか
  • CQ52 眼瞼けいれんにおいて手術治療はどのように位置づけられますか
  • CQ53 眼瞼けいれんに効果のある感覚トリックを応用した行動や装具にどのようなものがありますか
  • CQ54 眼瞼けいれんにおける感覚過敏症状 ( 羞明、疼痛 ) に対する直接の治療はありますか
  • CQ55 薬剤性眼瞼けいれんにおいて、薬物の減薬、離脱における注意点がありますか
  • CQ56 眼瞼けいれんのボツリヌス治療が効かなくなったらどうしたら良いですか
  • CQ57 ボツリヌス治療の効果が少なかったときに、追加の投与は可能なのでしょうか
  • CQ58 片側顔面痙攣との合併はあるのでしょうか また、その際の治療方法は通常と変わるのでしょうか
  • G 生活・福祉
  • CQ59 眼瞼けいれんが日常生活に与える影響とはどのようなものですか
  • CQ60 眼瞼けいれんは身体障害者手帳や障害年金など社会的な支援がつきますか
  • CQ61 眼瞼けいれんと照明の関係の検討は行われていますか
  • CQ62 眼瞼けいれんでは、起床時や何かに集中しているときに、病気の存在を忘れるという例が比較的軽症例にみられますが、なぜでしょうか
  • 奥付

この書籍の参考文献

参考文献のリンクは、リンク先の都合等により正しく表示されない場合がありますので、あらかじめご了承下さい。

本参考文献は電子書籍掲載内容を元にしております。

A 全体像・概念

P.11 掲載の参考文献
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P.13 掲載の参考文献
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P.15 掲載の参考文献
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P.16 掲載の参考文献
1) 若倉雅登 : 眼瞼痙攣の診断と治療. 神経眼科 17 : 497-498, 2000
 
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6) Wakakura M, Tsubouchi T, et al : Etizolam and benzodiazepine induced blepharospasm. J Neurol Neurosurg Psychiatry 75 : 506-507, 2004
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7) Wakakura M, Yamagami A, et al : Blepharospasm in Japan : A clinical observational study from a large referral hospital in Tokyo. Neuroophthalmology 42 : 275-283, 2018
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P.18 掲載の参考文献
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P.20 掲載の参考文献
1) Siokas V, Kardaras D, et al : BDNF rs6265 (Val66Met) Polymorphism as a Risk Factor for Blepharospasm. Neuromolecular Med 21 : 68-74, 2019
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3) Tian J, Vemula SR, et al : Whole-exome sequencing for variant discovery in blepharospasm. Mol Genet Genomic Med 6 : 601-626, 2018
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7) Wakakura M, Yamagami A, et al : Blepharospasm in Japan : A Clinical Observational Study From a Large Referral Hospital in Tokyo. Neuroophthalmology 42 : 275-283, 2018
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8) Molloy A, Williams L, et al : Sun exposure is an environmental factor for the development of blepharospasm. J Neurol Neurosurg Psychiatry 87 : 420-424, 2016
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9) Jutzeler CR, Curt A, et al : Relationship between chronic pain and brain reorganization after deafferentation : A systematic review of functional MRI findings. Neuroimage Clin 9 : 599-606, 2015
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10) Fayers T, Shaw SR, et al : Changes in corneal aesthesiometry and the subbasal nerve plexus in benign essential blepharospasm. Br J Ophthalmol 99 : 1509-1513, 2015
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12) Jiang W, Lan Y, et al : Abnormal spontaneous neural activity of brain regions in patients with primary blepharospasm at rest. J Neurol Sci 403 : 44-49, 2019
 
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P.23 掲載の参考文献
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P.25 掲載の参考文献
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B 診断・検査・鑑別・合併症

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C 症状・徴候・危険因子

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2) 清澤源弘, 鈴木幸久 : 眼瞼けいれん, 臨精医 36 増 : 251-254, 2007
 
3) 高木美昭, 小谷博和, 他 : 向精神薬内服中の患者における眼瞼けいれんの検討. 臨眼 64 : 297-301, 2010
 
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6) Bergman H, Bhoopathi PS, et al : Benzodiazepines for antipsychotic-induced tardive dyskinesia. Cochrane Database Syst Rev 1 : CD000205, 2018
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9) Tsubota K, Fujihara T, et al : Dry eye and Meige's syndrome. Br J Ophthalmol 81 : 439-442, 1997
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3) Tommasi G, Krack P, et al : Effects of varying subthalamic nucleus stimulation on apraxia of lid opening in Parkinson's disease. J Neurol 259 : 1944-1950, 2012
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1) Jankovic J, Orman J : Blepharospasm : demographic and clinical survey of 250 patients. Ann Ophthalmol 16 : 371-376, 1984
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2) Peckham EL, Lopez G, et al : Clinical features of patients with blepharospasm : a report of 240 patients. Eur J Neurol 18 : 382-386, 2011
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3) Sun Y, Tsai PJ, et al : Epidemiology of benign essential blepharospasm : A nationwide population-based retrospective study in Taiwan. PLoS One 13 : e0209558, 2018
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4) Suzuki Y, Mizoguchi S, et al : Glucose hypermetabolism in the thalamus of patients with essential blepharospasm. J Neurol 254 : 890-896, 2007
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5) Ramdhani RA, Kumar V, et al : What's special about task in dystonia? A voxel-based morphometry and diffusion weighted imaging study. Mov Disord 29 : 1141-1150, 2014
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1) Peckham EL, Lopez G, et al : Clinical features of patients with blepharospasm : a report of 240 patients. Eur J Neurol 18 : 382-386, 2011
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2) Defazio G, Martino D, et al : Influence of coffee drinking and cigarette smoking on the risk of primary late onset blepharospasm : evidence from a multicentre case control study. J Neurol Neurosurg Psychiatry 78 : 877-879, 2007
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3) Siokas V, Kardaras D, et al : CYP1A2 rs762551 and ADORA2A rs5760423 Polymorphisms in Patients with Blepharospasm. J Mol Neurosci 70 : 1370-1375, 2020
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4) Miranda AM, Steluti J, et al : The association between genetic risk score and blood pressure is modified by coffee consumption : Gene-diet interaction analysis in a population-based study. Clin Nutr 38 : 1721-1728, 2019
 
5) Arita R, Yanagi Y, et al : Caffeine increases tear volume depending on polymorphisms within the adenosine A2a receptor gene and cytochrome P450 1A2. Ophthalmology 119 : 972-978, 2012
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6) Defazio G, Berardelli A, et al : Possible risk factors for primary adult onset dystonia : a case-control investigation by the Italian Movement Disorders Study Group. J Neurol Neurosurg Psychiatry 64 : 25-32, 1998
 
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1) 目崎高広, 梶龍兒 : 眼瞼スパスム. Clin Neurosci 18 : 536-537, 2000
 
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2) Weiss EM, Hershey T, et al : Relative risk of spread of symptoms among the focal onset primary dystonias. Mov Disord 21 : 1175-1181, 2006
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D メカニズム・研究

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4) Herz NL, Yen MT : Modulation of sensory photophobia in essential blepharospasm with chromatic lenses. Ophthalmology 112 : 2208-2211, 2005
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5) ボトックス注用50単位・ボトックス注用100単位添付文書. グラクソ・スミスクライン株式会社, 2018年5月改訂
 
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E ドライアイ関連

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F 治療

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G 生活・福祉

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