Cyto-protection ＆ biology Vol.7 1989年 第7回 サイトプロテクション研究会

出版社： 癌と化学療法社
著者：
発行日： 1989-12-26
分野： 臨床医学：基礎  >  臨床細胞学
ISSN： 0289-368
電子書籍版： 1989-12-26
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1989年　第7回　サイトプロテクション研究会。今回も胃粘膜障害、脳、結合組織代謝、肝、ショック、内皮細胞、フリーラジカル、その他と多岐にわたり限られた時間ではあったが十分に討議された。特別講演として岐阜大学医学部　野澤義則教授、東京医科歯科大学室田誠逸教授にお話いただいた。

目次

  • 表紙
  • 序文
  • 目次
  • 特別講演 I
  • Ca2+動員受容体の活性化機構
  • 特別講演 II
  • 血管内皮細胞傷害とその制御
  • Session 胃粘膜障害I
  • 座長所感
  • 0.35N塩酸経口投与後のラット胃のadaptive cytoprotectionと胃粘膜内プロスタグランディン量および胃粘膜下血流量の変動に関する検討
  • 熱傷ストレスによる胃粘液物質の変動に関する検討
  • 実験的ストレス潰瘍の発生および治癒過程における胃粘膜血流量の変動とその調節因子
  • 虚血性胃粘膜病変形成における血小板活性化因子(PAF)の役割
  • 消化管粘膜におけるコンキャナバリンA陽性粘液の分布と変動
  • 家兎急性肝不全モデルにおける胃粘膜および腎ホスホリパーゼA2とアラキドン酸代謝の変動
  • Session 胃粘膜障害II
  • 座長所感
  • 肝硬変時胃粘膜病変の成因に関する実験的検討-慢性胆汁酸負荷の胃粘膜リン脂質に及ぼす影響について-
  • 急性胃粘膜病変の発現と酸化的ストレス
  • ヒト胃粘膜の重炭酸分泌
  • 各種抗潰瘍薬の胃微小循環に及ぼす影響
  • 胆汁酸による胃粘膜細胞機能障害に及ぼすPGE2, cimetidine, Solcoseryl投与の影響
  • Session 胃粘膜簿害・結合組織代謝
  • 座長
  • Epidermal growth factor(EGF)のエタノール潰瘍に対する効果
  • 腎不全の胃粘膜ヘキソサミンに及ぼす影響-幼牛血液抽出剤の予防効果を含めて-
  • H2受容体拮抗剤の胃粘液に対する作用
  • CamPylobacter Pyloriが産生する菌体外酵素によるヒト胃粘液の消化
  • 胃粘膜結合組織代謝からみたアスピリン潰瘍およびアスピリン+水浸拘束潰瘍の病態
  • 低出力レーザーの結合組織代謝に及ぼす影響の実験的研究
  • Session 肝・ショック
  • 座長所感
  • エンドトキシン肝障害の発症機序についての検討-特に血小板活性化因子との関連について-
  • 出血性ショック,細菌性ショックにおける循環動態ならびに生体防御反応について
  • ラットエンドトキシンショックにおけるthromboxane receptor antagonist, ONO-3708の効果
  • 虚血性肝障害に対する高気圧酸素療法の効果
  • 虚血性肝不全に対するソルコセリル投与の有効性
  • 肝保存に関する基礎的研究-培養肝細胞の低温保存における酸素の必要性の検討-
  • 冷阻血障害に対するCoQ10, urinastatinの細胞保護効果に関する検討-肝血流遮断低温灌流モデルを用いて-
  • Isolated liver perfusion modelを用いた肝冷却灌流保存後の肝機能評価
  • Session 内皮細胞・ほか
  • 座長所感
  • 静脈内皮に対するカルシウム拮抗剤の保護効果に関する形態学的検討
  • サイトカインによる血管内皮細胞の機能修飾
  • 血小板活性化における陽イオンおよび陰イオンの関与 -特にアラキドン酸動員について-
  • 肝細胞癌患者におけるLAK活性誘導についての免疫学的検討
  • 細胞生物活性の指標としての細胞内ATP量
  • Session 脳I
  • 座長所感
  • 虚血後の海馬におけるセカンドメッセンジャー
  • 虚血中早期に起こる脳内カルシウム局在の変化
  • 虚血性脳血管障害におけるplatelet-activating factor(PAF)の意義
  • 興奮性アミノ酸による脳組織間質液中アデノシンの動態-脳微小透析法を用いたラット海馬での検討-
  • Session 脳II
  • 座長所感
  • 自律神経反射に及ぼす脳虚血の影響に関する基礎的研究-組織呼吸賦活剤Solcoserylの効果-
  • 加齢による脳ライソゾームの変化
  • 慢性硬膜下血腫におけるXe-CT-scanによる局所脳循環測定
  • Session フリーラジカルI
  • 座長所感
  • 肝ミクロソームのエタノール代謝と活性酸素の役割-金属イオン,特に鉄イオンの意義-
  • 食餌制限ストレスに対する生体防御機構-特に免疫系を中心に-
  • 慢性腎不全患者の血液透析中に起こる好中球O2産生の変動の意義
  • アシルSOD誘導体による角膜炎の阻止軽減
  • フリーラジカルによる生体膜障害とアスタキサンチンによるその防止
  • 活性酸素種に対するプロテアーゼインヒビターの効果
  • Session フリーラジカルII
  • 座長所感
  • ソルコセリルの抗酸化能について
  • 遅発性神経細胞壊死における活性酸素の関与について
  • 虚血再灌流モデルとしての皮弁壊死と活性酸素
  • 雑種成犬温阻血肺における各種抗酸化剤の効果に関する実験的検討
  • 脾臓皮下固着ラットを用いた全肝虚血モデルの検討
  • 索引
  • 奥付

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本参考文献は電子書籍掲載内容を元にしております。

特別講演 I

P.8 掲載の参考文献
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3) Rhee SG, Suh P-G, Ryu S-H, et al:Studies of inositol phospholipid-specific phospholipase C. Science 244:546-550, 1989.
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4) Bennett CF, Balcarek JM, Varrichio A, et al:Molecular cloning and complete amino-acid sequence of form-1 phosphoinositide-specific phospholipase C. Nature Lond. 334:268-270, 1988.
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5) Stahl ML, Ferenz CR, Kelleher KL, et al:Sequence similarity of phospholipase C with the non-catalytic region of src. Nature Lond. 332:269-272, 1988.
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6) Mayer BJ, Hamaguchi M, Hanafusa H:Anobel viral oncogene with structural similarity to phospholipase C. Nature Lond. 332:272-275, 1988.
 
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9) Homma Y, Imaki J, Nakanishi O, et al:Isolation and characterization of two different forms of inositol phospholipid-specific phospholipase C from rat brain. J. Biol. Chem. 263:6592-6598, 1988.
 
10) 岡島史和:GTP 結合蛋白質とイノシトールリン脂質代謝. 代謝 25:237-248, 1988.
 
11) Ashkenazi A, Peralta EG, Winslow JW, et al:Functionally distinct G proteins selectively couple different receptors to PI hydrolysis in the same cell. Cell 56:487-493, 1989.
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12) Wakelam MJO, Davies SA, Houslay MD, et al:Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production. Nature Lond. 323:173-176, 1986.
 
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14) Lerea KM, Glomset JA, Krebs EG:Agents that elevate cAMP levels in platelets decrease thrombin binding. J. Biol. Chem. 262:282-288, 1987.
 
15) Yada Y, Nagao S, Okano Y, et al:Inhibition by cyclic AMP of guanine nucleotide-induced activation of phosphoinositide-specific phospholipase C in human platelets. FEBS Letters 242:368-372, 1989.
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16) Wahl MI, Daniel TO, Carpenter G:Antiphosphotyrosine recovery of phospholipase C activity after EGF treatment of A-431 cells. Science 241:968-970, 1988.
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17) 野沢義則:カルシウム動員レセプターの活性化機構-膜リン脂質を介する情報変換. 薬学雑誌 107:921-932, 1987.
 
18) Majerus PW, Connolly TM, Deckmyn H, et al:The metabolism of phosphoinositide-derived messenger molecules. Science 234:1519-1526, 1986.
 
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特別講演 II

P.22 掲載の参考文献
1) Eldor A, Falcone DJ, Hajjar DP, et al:Diet-induced hypercholesterolemia inhibits the recovery of prostacyclin production by injured rabbit aorta. Am. J. Pathol. 107:186-190, 1982.
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2) Abe M, Morita I, Murota S:A new in vitro method using Fura-2 for the quantification of endothelial cell injury. PG. LT. EFA. 34:69-74, 1988.
 
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4) Watanabe T, Morita I, Nishi H, et al:Preventive effect of MCI-186 on 15-HPETE induced vascular endothelial cell injury in vitro. PG. LT. EFA. 33:81-87, 1988.
 

Session 胃粘膜障害I

P.32 掲載の参考文献
1) Robert A, Nezamis JE, Lancaster C, et al:Mild Irritants prevent gastric necrosis through "adaptive cytoprotection" mediated by prostaglandins. Am. J. Physiol. 245:G113-G121, 1983b.
 
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3) Wallace JL:Increased resistance of the rat gastric mucosa to hemorrhagic damage after exposure to an irritant;role of the "mucoid cap" and prostaglandin synthesis. Gastroenterol. 94:22-32, 1988.
 
4) 金沢 寛:水浸拘束ストレス潰瘍発生における catecholamines と交感神経系の役割に関する研究. 日消誌 77:1345-1354, 1980.
 
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7) Powell WS:Rapid extraction of oxygenated metabolites of arachidonic acid from biological samples using octadecylsilyl silica. Prostaglandins 20:947-957, 1980.
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8) Shindo N, Saito T, Murayama K:Rapid quantification of 11 prostanoids by combined capillary column gas chromatography and negative ion chemical ionization mass spectrometry; application to prostanoids released from normal human embryonic lung fibroblasts W138 in a culture medium. Biomed. Environ Mass Spectrom. 15:25-32, 1988.
 
9) 工藤 猛:Stress 潰瘍発生における胃粘膜下血流量におよぼす自律神経ならびに catecholamines の影響に関する実験的研究. 日消誌 81:987-995, 1984.
 
10) Murakami M, Moriga M, Miyake T, et al:Contact electrode method in hydrogen gas clearance technique;a new method for determination of regional gastric mucosal blood flow in animals and humans. Gastroenterol. 82:457-467, 1982.
 
11) Whittle BJR, Higgs GA, Eakins KE, et al:Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa. Nature 284:271-273, 1980.
 
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13) 織田道宏:Adaptive cytoprotectionにおけるラット胃粘膜内プロスタノイド量および胃粘膜下血流量に関する検討. 日消誌 87(3):(印刷中)
 
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16) 岡本 伸:胃疾患における胃粘膜内糖蛋白質の正合成に関する研究 (第1編:ヒト胃粘膜内 UDP-galactosyl transferase の基礎的検討). 日消誌 78:1713-1719, 1981.
 
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18) Konturek SJ, Robert A:Cytoprotection of canine gastric mucosa by prostacyclin. Possible mediation by increased mucosal blood flow. Digestion 25:155-163, 1982.
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PubMed
P.55 掲載の参考文献
1) 田村茂樹, 中村紀夫, 坂口友次朗, 他:ヒト胃粘膜血流量の部位的差異. Cyto-Protection & biology. 3:191-199, 1985.
 
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10) 中村紀夫, 坂口友次朗, 長州堯雄, 他:胃粘膜血液からみた胃底腺・幽門腺領域の特徴と急性胃潰瘍の発生. 消化管粘膜の防御機構-粘膜血流を中心として-(川井啓市編). 第1版, 医学図書出版, 東京, 1982, pp. 175-182.
 
11) 永津俊治:カテコールアミン代謝と関連酵素-in vivo での代謝速度と酵素活性測定法-. 蛋白質核酸酵素 26:1307-1320, 1981.
 
12) Orloff LA, Orloff MS, Bunnett NW, et al:Dopamine and Norepinephrine in the alimentary tract changes ofter chemical sympathectomy and surgical vagotomy, Life Sci. 36:1625-1631, 1985.
 
13) 荒川規矩男:レニン・アンジオテンシン・アルドステロン系. 日本臨牀 9:2-3, 1982.
 
14) 瀧下修一, 尾前照雄:カテコールアミン系. 日本臨牀 9:51-58, 1982.
 
P.62 掲載の参考文献
1) Rosam A-C, Wallace JL, Whittle BJR:Potent ulcerogenic actions of platelet-activating factor on the stomach. Nature 319:54-56, 1986.
 
2) Wallace JL, Steel G, Whittle BJR, et al:Evidence for platelet-activating factor as a mediator of endotoxin-induced gastrointestinal damage in the rat. Gastroenterol. 93:765-773, 1987.
 
3) Itoh M, Guth PH:Role of oxygen-derived free radicals in hemorrhagic shock-induced gastric lesions in the rat. Gastroenterol. 88:1162-1167, 1985.
 
4) Shaw JO, Pinckard RN, Ferrigni KS, et al:Activation of human neutrophils with 1-0-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (platelet activating factor). J. Immunol. 127:1250-1255, 1981.
 
5) Prevost MC, Cariven C, Simon MF, et al:Platelet activating factor (PAF-acether) is released into rat pulmonary alveolar fluid as a consequence of hypoxia. Biochem. Biophys. Res. Commun. 119:58-63, 1984.
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6) Yasue N, Guth PH:Role of exogenous acid and retransfusion in hemorrhagic shock-induced gastric lesions in the rat. Gastroenterol. 94:1135-1143, 1988.
 
7) Benveniste J, Henson PM, Cochrane CG:Leukocyte-dependent histamine release from rabbit platelets. The role of IgE, basophils and a platelet activating factor. J. Exp. Med. 136:1356-1377, 1972.
 
8) Demopoulos CA, Pinckard RN, Hanahan DJ:Platelet activating factor;Evidence for 1-0-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (a new class of lipid chemical mediators). J. Biol. Chem. 245:9355-9358, 1979.
 
9) Smith SM, Grisham MB, Manci EA, et al:Gastric mucosal injury in the rat. Role of iron and xanthine oxidase. Gastroenterol. 92:950-956, 1987.
 
10) Beckman JS, Freeman BA.:Antioxidant enzymes as mechanistic probes of oxygen-dependent toxicity. Am. Physiol. Soc. Maryland:39-53, 1986.
 
11) 鈴木雅之, 末松 誠, 三浦総一郎, 他:急性胃粘膜病変形成時の活性酸素産生における xanthine oxidase 系および好中球の役割. 日消誌 85:835-842, 1988.
 
12) Grisham MB, Hernandez LA, Granger DN:Xanthine oxidase and neutrophil infiltration in intestinal ischemia. Am. J. Physiol. 14:G567-574, 1986.
 
13) 末松 誠, 永田博司, 三浦総一郎, 他:侵襲時微小循環障害における局所血中多形核白血球 respiratory burst および脂質過酸化反応の変動. 血管 9:119-125, 1986.
 
14) Jarasch ED, Bruder G, Heid HW:Significance of xanthine oxidase in capillary endothelial cells. Acta Phys. Scand. Suppl. 548:39-46, 1986.
 
P.69 掲載の参考文献
1) 小林絢三:胃粘膜防御機構とは. 臨床消化器内科 2:1517-1524, 1987.
 
2) 平松紘一, 鎌田武信, 阿部 裕, 他:胃粘膜関門とその周辺 (三好秋馬, 竹本忠良編). 第1版, 羊土社, 東京, 1979, pp. 41-63.
 
3) 石田康男, 木根渕光夫, 鈴木快輔, 他:胃粘液による胃壁防御. Cyto-protection & biology 2:183-188, 1984.
 
4) 石田康男, 高橋愛樹, 鈴木快輔, 他:胃粘膜内の防御因子. Cyto-protection & biology 6:41-48, 1988.
 
5) 固武健二郎:レクチン染色による1, 2-dimethylhydrazine 誘発ラット大腸腫瘍およびヒト大腸腫瘍の組織化学的研究. 日外会誌 4:534-545, 1988.
 
6) Nakayama J, Katsuyama T, Ono K, et al:Large bowel carcinomaspecific antigens detected by the lectin, Griffonia simplicifolia aggulutinin-II. Jpn. J. Cancer Res. (Gann) 76:1078-1084, 1985.
 
7) 小野謙三:大腸の正常粘膜および上皮性腫瘍における粘液の組織化学的研究. 信州医誌 1:110-139, 1982.
 
P.75 掲載の参考文献
1) 高木正博, 福井 博, 植村正人, 他:急性肝不全における消化管出血の病態と治療に関する基礎的研究. 幼牛血液抽出剤, H2-受容体拮抗剤の胃粘膜防御因子に及ぼす影響. Cyto-protection & biology 3:89-97, 1985.
 
2) 植村師子:劇症肝炎における腎不全の発現機序に関する臨床的および実験的研究-尿および腎内プロスタグランディンの動態とその意義について-. 奈医誌 37:465-478, 1986.
 
3) Kawata S, Chitranukroh A, Owen JS, et al:Membrane lipid changes in erythrocyte, liver and kidney in acute and chronic experimental liver disease in rats. Biochim. Biophys. Acta 896:26-34, 1987.
PubMed
4) 稲田正己, 河田純男, 松田幸彦, 他:D-galactosamine 投与急性肝不全家兎における腎アラキドン酸代謝の変動. 肝臓 29:135-140, 1988.
 
5) 稲田正己, 河田純男, 松田幸彦, 他:家兎急性肝不全モデルにおける胃粘膜アラキドン酸代謝の変動. Cyto-protection & biology 6:117-122, 1988.
 
6) 荒川哲男, 中村 肇, 蝶野慎治, 他:ラット胃粘膜 prostaglandin E2に関する研究 (第1報)-測定法の確立と非ステロイド系抗炎症剤による影響について-. 日消誌77:1052-1059, 1980.
 
7) 稲川寿夫:Radioimmunoassay法による prostaglandin の分離定量に関する検討. 薬学雑誌 92:1187-1194, 1972.
 
8) Tojo H, Ono T, Kuramitsu S, et al:Aphospholipase A2 in the supernatant fraction of rat spleen. Its similarity to rat pancreatic phospholipase A2. J. Biol. Chem. 263:5724-5731, 1988.
 
9) Tojo H, Ono T, Okamoto M:Apancreatic-type phospholipase A2 in rat gastric mucosa. Biochem. Biophys. Res. Commun. 151:1188-1193, 1988.
 
10) Hirohara J, Sugatani J, Okumura T, et al:Properties and localization of phospholipase A2 activity in rat stomach. Biochim. Biophys. Acta 919:231-238, 1987.
PubMed
11) 岡田昌之, 土居利光, 金沢雅弘, 他:急性ストレス潰瘍におよぼす副腎の影響. Cyto-protection & biology 2:145-155. 1984.
 

Session 胃粘膜障害II

P.84 掲載の参考文献
1) Fisher MA, Hunt JN:A sensitive method for measuring hemoglobin in gastric contents. Digestion 14:409-414, 1976.
PubMed
2) Skillmann JJ, Gould SA, Chung RS, et al:The gastric mucosal barrier. Ann. Surg. 172:564-582, 1972.
 
3) Kates M:Techniques of lipidology, Lipid (edited by Work TS). E. Work, North Holland, Amsterdam, 1972, pp. 330.
 
4) シンポジウムII, 肝疾患と消化管病変 (司会:市田文弘, 木原 疆). Gastroent. End. 28:1129-1154, 1986.
 
5) 加藤抱一:門脈圧亢進症例における胃酸分泌. 日消誌 76:1427-1439, 1979.
 
6) Ostrow JD, Timmerman RJ, Gray SJ:Gastric secretion in human hepatic cirrhosis. Gastroenterol. 38:303-313, 1960.
 
7) 日高令一郎:肝硬変症時の胃粘膜血流動態の検討-特に食道静脈瘤硬化療法前後での比較と胃粘膜病変との関連について-. Gastroent. End. 27:1929-1939, 1985.
 
8) 坂崎庄平, 宋 星胎, 佐竹克彦, 他:肝硬変ラットにおける消化性潰瘍の成因に関する検討-ことに粘膜血流-. 日消誌 79:601, 1982
 
9) Mann NS:Bile-induced acute erosive gastritis. Its prevention by antacid, cholestyramine, and prostaglandin E2. Am. J. Dig. Dis. 21:89-92, 1986.
 
10) Arakawa T, Satoh H, Kobayashi K, et al:Endogenous prostaglandin E2 in gastric mucosa of patients with alcoholic cirrhosis and portal hypertension. Gastroenterol. 93:135-140, 1987.
 
11) 水上祐治:慢性肝疾患における十二指腸運動機能と膵外分泌機能との関連性について. 日消誌 85:227-235, 1988.
 
12) 坂上 博, 水上祐治, 細川鎮史, 他:肝硬変時の胃病変発現に関する検討-胆汁胃内逆流の影響について-. Cyto-protection & biology 5:315-322, 1987.
 
13) Davenport HW:Destruction of the gastric mucosal barrier by detergents and urea. Gastroenterol. 54:175-181, 1968.
 
14) 森賀本幸, 青野 充, 西沢幸夫:リン脂質. サイトプロテクションとその周辺 (竹本忠良編). 医歯薬出版杜, 東京, 1986, pp. 65-74.
 
15) 細川鎮史, 坂上 博, 水上祐治, 他:肝硬変時胃粘膜病変の成因に関する実験的検討-特に胆汁酸の影響について-. Cyto-protection & biology 6:23-30, 1988.
 
P.96 掲載の参考文献
1) Sies H:Oxidative stress. Academic Press, New York, 1985.
 
2) 井上正康, 荻野哲也, 安東由喜雄, 他:病巣指向性 SOD 誘導体の開発と生体酸素毒性の制御. フリーラジカルの臨床 Vol.2(大柳善彦他編). 日本医学館, 東京, 1987, pp. 83-91.
 
3) Ogino T, Inoue M, Ando Y, et al:Chemical modification of superoxide dismutase. Int. J. Peptide Protein Res. 32:153-159, 1988.
 
4) Ando Y, Inoue M, Hirota M, et al:Effect of a superoxide dismutase derivative on cold-induced brain edema. Brain Res 477:286-291, 1989.
PubMed
5) Watanabe N, Inoue M, Morino Y:Inhibition of postischemic reperfusion arrhythmias by an SOD derivative with prolonge in vivo half life. Biochem. Pharmacol. (in press)
 
6) Inoue M, Saito Y, Hirata E, et al:Regulation of redox status of plasma proteins by mechanism and transport of glutathione and related compounds. J. Protein Chem. 6:207-225, 1987.
 
7) Stocker R, Ames RN:Potential role of conjugated bilirubin and copper in the metabolism of lipid peroxides in bile. Proc. Natl. Acad. Sci. USA. 84:8130-8134, 1987.
 
8) Szabo S, Brown A:Prevention of ethanol-induced vascular injury and gastric mucosal lesions by sucralfate and its components. Proc. Soc. Exp. Biol. Med. 185:493-497, 1987.
PubMed
9) Hirota M, Inoue M, Ando Y, et al:Protection of stress-induced gastric injury of the rat by glutathione. Gastroenterol. (in press)
 
P.104 掲載の参考文献
1) George JD:New clinical method for measuring the rate of gastric empting;the double sampling test meal. Gut 9:237-242, 1968.
 
2) Schierbeck NP:Ueber Kohlensaure im Ven trikel. Scand. Arch. Physiol. 3:437-473, 1892.
 
3) Hollander F:The two-component mucus barrier. Arch. Int. Med. 94:107-120, 1954.
 
4) Heatly NG:Mucosubstance as a barrier to diffusion. Gastroenterol. 37:313-317, 1959.
 
5) Feldman M, Colturi TJ:Effect of indomethacin on gastric acid and bicabonate secretion in humans. Gastroenterol. 87:1339-1343, 1984.
 
6) Forssell H, Olbe L:Continuous computerized determination of gastric bicabonate secretion in man. Scand. J. Gastroenterol. 20:767-774, 1985.
 
7) Rees WDW, Botham D, Turnberg LA:A demonstration of bicabonate production by the normal human stomach in vivo. Dig. Dis. Sci. 27:961-966, 1982.
 
8) Forssell H, Olbe L:Effect of fundic distension on gastric bicabonate secretion in man. Scand. J. Gastroenterol. 22:627-633, 1987.
 
9) Smith JL, Gamal MA, Chremos AN:Famotidine, a new H2-receptor antagonist effect on parietal, nonparietal, and pepsin secretion in man. Dig. Dis. Sci. 4:308-312, 1985.
PubMed
10) 白川敏夫, 中村三千男, 松本春樹, 他:内視鏡を用いた水素イオン back diffusion の測定 (第一報). 内科宝函 29:339-347, 1981.
 
11) Okabe S, Jinno H, Nishida A:Effect of 15 (R)-15-methyl prostaglandin E2 (arbaprostil) on gastric secretion and various gastric lesions induced in rats. Jpn. J. Pharmacol. 40:329-337, 1986.
 
12) Reele SB:Gastric antisecretory activity of arbaprostil as affected by gastric pH. Dig. Dis. Sci 30:612-616, 1985.
PubMed
P.111 掲載の参考文献
1) 長畑洋司, 裏川公章:ストレス潰瘍発生過程におけるドパミンの役割についての実験的研究. 日消誌 83:1289-1297, 1986.
 
2) Salvati P, Whitle BJR:Vascular actions of prostaglandins on the isolated perfused stomach of the rabbit. Brit. J. Pharmacol. 72:139-140, 1980.
 
3) 安積靖友, 裏川公章, 長畑洋司, 他:Dopamine の胃粘膜血流増加作用とその機序に関する実験的検討. 日消誌 85:1360-1368, 1988.
 
4) 長畑洋司, 裏川公章, 林 民樹, 他:2'-Carboxymethoxy-4, 4'bis (3-methyl-2-butenyloxy) Chal-cone のストレス潰瘍予防効果. 診療と新薬 25:1-5, 1988.
 
5) Kitajima M, Wolfe RR, Trelstad RL, et al:Gastric mucosal lesions after burn injury. J. Trauma 18:644-650, 1978.
PubMed
6) 和田八三久:液体の粘性. 力学物性 (和田八三久編). 初版, 共立出版, 東京, 1968. pp 4-15.
 
7) Krieger IM, Maron S:Direct determination of the flow curves of non-Newtonian fluids. J. Appl. Phys. 23:147-149, 1952.
 
8) 裏川公章, 熊谷仁人, 中本光春, 他:シメチジン出現後の手術適応の変遷. 日臨外会誌 47:418-424, 1986.
 
P.121 掲載の参考文献
1) 亀山仁一, 佐々木巌, 宮川英喜, 他:急性胃粘膜病変-閉塞性黄疸時における急性潰瘍についての実験的および臨床的研究-. 日消外会誌 15:1642-1645, 1982.
 
2) 神山泰彦, 松野正紀, 佐々木巌, 他:閉塞性黄疸に合併した術後急性潰瘍発生例の検討. 腹部救急診療の進歩 7:51-55, 1987.
 
3) 神山泰彦, 佐々木巌, 内藤広郎, 他:閉塞性黄疸の胃粘膜細胞機能におよぼす影響-ラット胃粘膜を用いた電気生理学的検討-. Therap. Res. 8:792-798, 1988.
 
4) 神山泰彦, 佐々木巌, 佐藤寿雄, 他:胆汁酸の胃粘膜細胞機能におよぼす影響-PGE2, cimetidine, Solcoseryl の効果を含めて-. Cyto-protection & biology 6:129-138, 1988.
 
5) Main IHM, Pearce JB:A rat isolated mucosal preparation for studying the pharmacology of gastric secretion and the synthesis or release of endogenous substance. J. Pharmacol. Method. 1:27-37, 1978.
 
6) Rothe CF, Quay JF, Armstrong WM:Measurement of epithelial electrical characteristics with an automatic voltage clamp device with compensation for fluid solution resistance. IEEE Trans. Biomed. Eng. BME-16:160-164, 1969.
 
7) Harman JW, Doong T, Gadacz TR:Bile acids are not equally damaging to the gastric mucosa. Surg. 84:79-86, 1978.
 
8) Carmichael HA, Nelson LM, Russell RI, et al:The effect of the synthetic prostaglandin analog 15 (R) 15 methyl PGE2 methyl ester on gastric mucosal hemorrahage induced in rats by taurocholic acid and hydrocholic acid. Am. J. Dig. Dis. 22:411-414, 1977.
 
9) Chaundhury TK, Jacobson ED:Prostaglandin cytoprotection of gastric mucosa. Gastroenterol. 74:59-63, 1978.
 
10) Jackson MJ, Norris SH:Transport of sodium and chloride across rat gastric mucosa in vitro. J. Physiol. 360:293-310, 1985.
PubMed
11) Okuda M, Murakami M, Miyahara T, et al:The pharmacological effect of Solcoseryl on gastric mucosal circulation 8 gastric acid secretion. Cyto-pro tection & biology 1:17-34, 1983.
 
12) 橋本岩雄, 山下義昭, 河合雅美, 他:ソルコセリルの細胞増殖促進作用;I. 鶏胎脳細胞増殖に及ぼす影響. 基礎と臨床 8:21-28, 1974.
Medical*Online
13) Guth PH, Aures D, Paulson G:Topical aspirin plus HCl gastric lesions in the rat. Cyto-protective effect of prostaglandin, cimetidine, and probanthine. Gastroenterol. 76:88-93, 1979.
 
14) Hiraishi H, Terano A, Ivey KJ, et al:Effect of cimetidine on indomethacin induced damage in cultured rat gastric mucosal cells;comparison with prostaglandin, J. Lab. Med. 108:608-615, 1986.
PubMed
15) Cheung LY, Portefield G:Is histamine a mediator in bile-induced gastric mucosal injury. J. Surg. Surg. Res. 24:272-276, 1978.
 
16) Duane WC, Wiegand DM:Mechanism by which bile salt disrupts the gastric mucosal barrier in the dog. J. Clin. Invest. 66:1044-1049, 1980.
 

Session 胃粘膜簿害・結合組織代謝

P.131 掲載の参考文献
1) Cohen S, Taylor JM:Epidermal growth factor;chemical and biological characterization Part I. Recent Prog. Horm. Res. 30:533-550, 1974.
 
2) Cohen S, Sovage RC Jr.:Recent studies on the chemistry and biology of epidermal growth factors Part II. Recent Prog. Horm. Res. 30:551-574, 1974.
 
3) Gregory H:Isolation and structure of urogastrone and its relationship to epidermal growth factor. Nature 257:325-327, 1975.
PubMed
4) Finke U, Rutten M, Morphy RA, et al:Effects of epidermal growth factor on acid secretion from guinea pig gastric mucosa:In vitro analysis. Gastroenterol. 88:1175-1182, 1985.
 
5) Konturek SJ, Brzozowskl T, Piastucki I, et al:Role of mucosal prostaglandins and DNA synthesis in gastric cytoprotection by luminal epidermal growth factor. Gut 22:927-932, 1989.
 
6) Robert A, Nezamis JE, Lancaster C, et al:Cytoprotection by prostaglandins in rats. Gastroenterol. 77:433-443, 1979.
 
7) 平田結喜緒:特集 成長因子とその周辺 蛋白ポリペプチド系成長因子-上皮成長因子-. 日本臨牀 44:7-15, 1986.
 
8) Carpenter G, Cohen S:Human epidermal growth factor and the proliferation of human fibroblasts. J. Cell Physiol. 88:227-238, 1976.
PubMed
9) Scheving LA, Yeh YC, Tsai TH, et al:Circadian phase-dependent stimulatory effects of epidermal growth factor on deoxyribonucleic acid synthesis in the duodenum, jejunum, ileum, caecum, colon and rectum of the adult male mouse. Endocrinol 106:1498-1503, 1980.
 
10) Johnson LR, Guthrie PO:Stimulation of rat oxyntic gland mucosal growth by epidermal growth factor. Am. J. Physiol. 238:G45-49, 1980.
 
11) 安井 弥, 住吉博道, 加登本幸久, 他:ラット消化管粘膜上皮に対する EGF およびガストリンの影響. 消化管ホルモン VII. EGF 31:214-221, 1988.
 
12) Szabo S:Mechanisms of mucosal injury in the stomach and duodenum:Time sequence analysis of morphologic, functional, biochemical and bistochemical studies. Scand. J. Gastroent. 22 (Suppl. 127):21-28, 1987.
 
P.138 掲載の参考文献
1) Kleinknecht D, Jungers P, Chanard J, et al:Uremic and non-uremic complications in acute renal failure:Evaluation of early and frequent dialysis on prognosis. Kidney Int. 1:190-196, 1972.
PubMed
2) 真柄頴一:急性腎不全に関する研究-第一報, 急性腎不全の臨床的研究-. 日腎誌 3:215-231, 1978.
 
3) 青柳和彦, 長島道夫, 中原秀樹, 他:心臓手術後の消化管出血について-術後急性腎不全との関連-. 日胸外会誌 31:354-363, 1983.
 
4) 亀山仁一, 仁科盛之, 鈴木祐子, 他:ソルコセリルおよび迷切の潰瘍発生に対する予防効果とその機序について-急性腎不全時を含めて-. Cyto-protection & biology 5:323-330, 1987.
 
5) Takagi K, Okabe S:The effect of drugs on the production and recovery processes of the stress ulcer. Jap. J. Pharmac. 18:9-18, 1968.
 
6) 石原和彦, 森下 薫, 小原 進, 他:胃粘液含量測定法としての胃粘膜ヘキソサミン定量の妥当性についての検討. 日消誌 86:111, 1989.
 
7) Takagaki YM, Hotta K:Characterization of peptic inhibitory activity associated with sulfated glycoprotein isolated from gastric mucosa. Biochim. Biophys. Acta 584:288-297, 1979.
 
8) 堀田恭子:粘液の生化学. 臨床科学 20:1417-1422, 1984.
 
9) 堀田恭子:粘液, 消化性潰瘍の新しい展開. Cyto-protection & biology 4:149-164, 1986.
 
10) Azuumi Y, Ohara S, Ishihara K, et al:Correlation of quantitative changes of gastric mucosal glycoproteins with aspirin-induced gastric damage in rats. Gut 26:533-536, 1980.
 
11) 桑田 肇, 石原和彦, 堀田恭子, 他:エタノール投与による実験的胃潰瘍におけるラット胃粘膜糖タンパク質の変動. 日消誌 82:28-33, 1985.
 
12) 工藤 猛, 渡部洋三, 佐々木浩, 他:水浸拘束ストレス潰瘍発生における胃血流量と胃粘液分泌に関する研究. Cyto-protection & biology 2:97-105, 1984.
 
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Session 肝・ショック

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4) Seglen PO:Preparation of isolated rat liver cells. In Methods in Cell Biology (edited by presscot DM). Vol. 13, Academic Press, New York, 1976, pp. 29-83.
 
5) Schanne FAX, Kane AB, Young EE:Calcium dependence of toxic cell death:A final common path-way. Science 206:700-702, 1937.
 
6) Hashimoto T, Negawa Y, Tagawa K:Properties of binding sites for adenine nucleotides on ATPase from yeast mitochondria. J. Biochem. 90:1141-1150, 1981.
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7) 真杉文紀, 中村哲也:Sodium dodecyl-sulphate 可溶化による肝チオバルビツール酸値とビタミンE, 薬物によるその変動. ビタミン 51:21-29, 1977.
 
8) Johnson RWG, Anderson M, Morley AR:Twenty-four hour preservation of kidney injured by prolonged warm ischemia. Transplantation 13:174-179, 1972.
 
9) Stephenson TP, O'Donoghue EPN, Hendry WF:Preservation of human kidneys for transplan-tation:Preliminary results with a Gambro perfusion machine. Br. Med. J. 1:379-381, 1973.
 
10) Pegg DE, Green CJ, Foreman J:Renal preservation by hypothermic perfusion. 2:The influence of oxygenator design and oxygen tensin. Cryobiology 11:238-247, 1974.
 
11) Palombo JD, Hirschberg Y, Pomposelli JJ:Decreased loss of liver adenosine triphosphate during hypothermic preservation in rats pretreated with glucose;Implications for organ donor management. Gastroenterol. 95:1043-1049, 1988.
 
12) Grundmann R, Pitschi H, Berr F:Nonpulsatile vs pulsatile canine kidney perfusion. Surgery 75:178-184, 1974.
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13) Olson LM, Klintmalm GB, Husberg BS:Superoxide dismutase improves organ preservation in liver transplantation. Transprant. Proc. 20 (1):961-964, 1988.
 
P.234 掲載の参考文献
1) 小暮洋暉:肝保存に関する研究, 特に生体内選択的肝低温灌流法による肝機能の変動を中心として. 日外会誌 5:608-627, 1970.
 
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4) Crane FL, Hatefi Y, Lester RL, et al:Isolation of a quinone form beef heart mitochondria. Biochem. Biophys. Acta 25:220-221, 1957.
 
5) Marubayashi S, Takenaka M, Dohi K, et al:Adenine nucleotide metabolism during hepatic ischemia and subsequent blood reflow periods and its relation to organ viability. Transplantation 30:294-296, 1980.
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6) Kobayashi M, Shimomura Y, Suzuki H, et al:Structual effect of ubiquinones on mitochondrial inner membrane. J. Appl. Biochem. 2:270-279, 1980.
 
7) Marubayashi S, Dohi K, Yamada K, et al:Changes in the levels of endogenous coenzyme Q homologs, α-tocopherol, and glutathione in rat liver after hepatic ischemia and reperfusion, and the effect of pretreatment with coenzyme Q10. Biochem. Biophys. Acta 797:1-9, 1984.
 
8) Sumitomo K, Inagawa K, Itoh H, et al:Ischemic damage prevention by coenzyme Q10 treatment of the donor before orthotopic liver transplantation. Biochemical and histologic findings. Surgery 102:821-827, 1987.
 
9) 小田利通, 鮫島輝子, 宮脇武徳, 他:ヒト尿中トリプシン阻害物質 (MR-20) の抗ショック作用について. 麻酔 32:137-142, 1984.
 
10) 小川 龍, 藤田達二:体外循環時のライソゾーム酵素血中遊離に及ぼすMR-20の影響. 麻酔 8:435-439, 1984.
 
11) 山本保博, 大塚敏文:イヌのエンドトキシンショックモデルにおけるUrinary Tripsin inhibitor 投与の肝循環動態に及ぼす影響. 最新医学 42:2727-2733, 1987.
 
P.243 掲載の参考文献
1) Toledo-Pereyra LH, Bergren CT:Liver preservation techniques for transprantation. Artificial Organs 11 (3):214-223, 1987.
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2) Howden B, Jablonski P, Grossman H, et al:The importance of the hepatic artery in rat liver transplantation. Transplant. 47:428-431, 1989.
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3) Starzl TE, Miller CM, Bronznick B, et al:An improved technique for multiple organ harvesting. Surg. Gynecol Obstet. 165:343-348, 1987.
 
4) Shaw BW, Martin DJ, Marquez JM, et al:Venous bypass in clinical liver transplantation. Annu. Surg. 200:524-534, 1984.
 
5) Iwatsuki S, Starzl TE, Todo S, et al:Experience in 1,000 liver transplants under cyclosporinesteroid therapy, a survival report. Transplant. Proc. 20 (1):498-504, 1988.
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8) 横尾英一, 坪倉篤雄, 中西敏夫, 他:ラット肝ミトコンドリア機能に及ぼす熱傷毒およびソルコセリルの影響. Cyto-protection & biology 1:119-124, 1983.
 
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10) 野良敏明, 篠原正彦, 星野澄人, 他:肝循環動態に及ぼす肝流入血行遮断の影響. Cyto-Protection & biology 3:69-76, 1985.
 
11) 朝日憲治, 野良敏明, 原田明生, 他:肝切除後の肝循環動態の検討. Cyto-Protection & biology 4:45-52, 1986.
 
12) 土屋和彦, 中村順児, 細見 弘, 他:肺血管床における神経性・体液性調節とその生理学的役割. 脈管学 28 (4):247-254, 1988.
 

Session 内皮細胞・ほか

P.252 掲載の参考文献
1) Whitmer KR, Williams-Lawson JS, Highsmith RF, et al:Effect of calcium channel modulators on isolated endothelial cells. Biochem. Biophys. Res. Commun. 154:591-605, 1988.
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2) Jayakody RL, Kappagoda CT, Senarantne MPJ, et al:Absence of effect of calcium antagonists on endothelium-dependent relaxation in rabbit aorta. Br. J. Pharmac. 91:155-164, 1987.
 
3) Tayo FM, Bevan JA:Extracellular calcium dependence of contraction and endothelium-dependent relaxation varies along the length of the aorta and its branches. J. Pharmacol. Exp. Ther. 240:594-601, 1987.
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4) Miyawaki F, Matsumoto H:Efficacy of calcium antagonist in preservation of integrity of vein. Eur. Surg. Res. 19 (Suppl. 1):21-22, 1987.
 
P.257 掲載の参考文献
1) Maruyama I:The regulation of blood coagulation by the endothelium. Acta Haematol. Jbn. 49:146-153, 1986.
 
2) Maruyama I, Salem HH, Majerus PW:Coagulation factor Va binds to human umbilical vein endothelial cells and accelerates protein C activation. J. Clin. Invest. 74:224-230, 1984.
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3) Maruyama I, Majerus PW:The turnover of thrombin-thrombomodulin complex in cultured human umbilical vein endothelial cells and A549 lung cancer cells. Endocytosis and degradation of thrombin. J. Biol. Chem. 260:15432-15438, 1985.
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4) Nawroth PP, Stern DM:Modulation of endothelial cell hemostatic properties by tumor necrosis factor. J. Exp. Med. 163:740-745, 1986.
PubMed
5) Conway EM, Rosenberg RD:Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells. Molec. Cell Biol. 8:5588-5592, 1988.
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P.266 掲載の参考文献
1) Ozaki Y, Kume S:Functional responses of aequorin-loaded human neutrophils. Comparison with fura 2-loaded cells. Biochim. Biophys. Acta 972:113-119, 1988.
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2) Johnson PC, Ware JA, Cliveden PB, et al:Measurement of ionized calcium in blood platelets with the photoprotein aequorin. J. Biol. Chem. 260:2069-2076, 1985.
PubMed
3) Zavoico GB, Cragoe EJ Jr, Feinstein MB:Regulation of intracellular pH in human platelets. J. Biol. Chem. 261:13160-13167, 1986.
PubMed
4) Purdon AD, Patelunas D, Smith JB:Evidence for the release of arachidonic acid through the selective action of phospholipase A2 in thrombin-stimulated human platelets. Biochim. Biophys. Acta 920:205-214, 1987.
PubMed
P.273 掲載の参考文献
1) Grimm EA, Mazumder A, Zhang HA, et al:Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin 2 activated autologous human peripheral blood lymphocytes. J. Eep. Med. 155:1823-1841, 1982.
 
2) Lotze MT, Line BR, Mathisen DJ, et al:The in vivo distribution of autologous human and murine lymphoid cells grown in T cell growth factor (TCGF):Implications for the adoptive immunotherapy of tumors. J. Immunol. 125:1487-1493, 1980.
 
3) Ettinghausen SE, Lipford EH III, Mule JJ, et al:Recombinant interleukin 2 stimulates in vivo proliferation of adoptively transferred lymphokine-activated killer (LAK) cells. J. Immunol. 135:3623-3635, 1985.
 
4) Mule JJ, Shu S, Schwarz SL, et al:Adoptive immunotherapy of established pulmonary metastases with LAK cells and recombinant interleukin-2. Science 225:1487-1489, 1984.
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5) Lafreniere R, Rosenberg SA:Successful immunotherapy of murine experimental hepatic metastases with lymphokine-activated killer cells and recombinant interleukin 2. Cancer Res. 45:3735-3741, 1985.
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6) 是木一也, 坂本久浩, 奥野府夫, 他:肝細胞癌患者におけるLAK細胞誘導の免疫学的検討. 消化器と免疫 22:244-248, 1989.
 
7) 額田純一郎, 岩本 忍, 作田正義:マウス脾臓NK活性に及ぼすソルコセリルの影響. Cyto-Protection & biology 2:71-78, 1984.
 
8) 額田純一郎, 岩本 忍, 作田正義:マウス脾NK活性におよぼす幼牛血液抽出剤抽出分画の影響について. Cyto-protection & biology 3:119-126, 1985.
 
9) Salup RR, Back TC, Wiltrout RH:Successful treatment of advanced murine renal cell cancer by bicompartmental adoptive chemoimmunotherapy. J. Immunol. 138:641-647, 1987.
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10) 高後 裕, 坂牧純夫:LAK細胞の養子免疫療法と効果の解析. 日本臨床免疫学会総会抄録集 16:101, 1988.
 
11) 松浦 靖, 西原利治, 大西三朗, 他:肝細胞癌患者におけるLymphokine Activated Killer細胞活性 (LAK活性) 低下機序の検討-LAK活性誘導におけるγ-Interferon (γ-IFN) の関与について-. 日臨免誌 11:253-262, 1988.
 
12) 大西博昭, 奥野清隆, 中村哲彦, 他:低濃度Interleukin 2 (IL-2) と各種のBiological Response Modifier (BRM) 併用によるLymphokine-activated killer (LAK) 細胞活性増強の試み. 日癌治 23:2539-2545, 1988.
 
13) 高木 均, 高山 尚, 小島 亨, 他:各種Interferonによる肝癌培養細胞PLC/PRF/5に対するLAK活性増強効果の基礎的検討. 肝臓 29:611-618, 1988.
 
14) Raimondo FD, LaPushin R, Hersh EM:Synergism between alpha-interferon and interleukin-2-activated killer cells:In vitro studies. Acta Hematol. 78 (Suppl. 1):77-83, 1987.
 
15) Itoh K, Tilden AB, Kumagai K, et al:Leu-11+lymphocytes with natural killer (NK) activity are precursors of recombinant interleukin 2 (rIL 2)-induced activated killer (AK) cells. J. Immunol. 134:802-807, 1985.
 
16) Itoh K, Shiiba K, Shimizu Y, et al:Generation of activated killer (AK) cells by recombinant interleukin 2 (rIL 2) in collaboration with interferon一γ (IFN一γ). J. Immunol. 134:3124-3129, 1985.
 
P.280 掲載の参考文献
1) Dallne G:Viability and tetrazolium salt in ascites tumors. Nature 186:176, 1960.
 
2) 市橋秀仁, 近藤達平:酵素活性を指標とした感受性テスト. 癌と化学療法 9:575-581, 1982.
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3) 前原喜彦, 穴井秀明, 増田英隆, 他:SDI法によるヒト悪性腫瘍の制癌剤感受性試験. 癌と化学療法12:2018-2023, 1985.
 
4) 穴井秀明, 前原喜彦, 楠本宏記, 他:SDI法によるヒト悪性腫瘍の制癌剤感受性試験 (第2報). 癌と化学療法 13:2544-2548, 1986.
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5) Mosmann T:Rapid colorimetric assay for cellular growth and survival:Application to proliferation and cytotoxicity assays. J. Immunol. Methods 65:55-63, 1983.
PubMed
6) Kangas L, Gronroos M, Nieminen AL:Bioluminescence of cellular ATP;a new method for evaluating cytotoxic agents in vitro. Med. Biol. 62:338-343, 1984.
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7) Kuzmits R, Aiginger P, Frass M, et al:Influence of cytostatics on ATP-levels of leukemic cells. Adv. Exp. Med. Biol. 165:383-388, 1984.
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8) Garewal HS, Ahmann FR, Celniker A:The ATP assay;anti-cancer drug effects on malignant cell growth. Sci Proc. Am. Assoc. Cancer Res. 26:334, 1985.
 
9) Weisenthal LM, Marsden JA, Dill PL, et al:A novel dye exclusion method for testing in vitro chemosensitivity of human tumors. Cancer Res. 43:749-757, 1983.
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10) 斉藤和子, 佐々田裕子, 夏野徹也, 他:制癌剤感受性テストSDIの改良法. 癌と化学療法 7:1952-1958, 1980.
 
11) Anai H, Maehara Y, Kusumoto H, et al:Comparison between succinate dehydrogenase inhibition test and subrenal capsule assay for chemosensitivity testing. Oncology 44:115-117, 1987.
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12) Maehara Y, Anai H, Kusumoto H, et al:Poorly differentiated human gastric carcinoma is more sensitive to antitumor drugs than is well differentiated carcinoma. Eur. J. Surg. Oncol. 13:203-206, 1987.
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13) Maehera Y, Anai H, Tamada R, et al:The ATP assay is more sensitive than the succinate dehydrogenase inhibition test for predicting cell viability. Eur. J. Cancer Clin. Oncol. 23:273-276, 1987.
 
14) 前原喜彦, 宮本京子, 穴井秀明, 他:In vitro 制癌剤感受性試験のSDI法とATP法の比較. 癌と化学療法 14:630-634, 1987.
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15) 前原喜彦, 穴井秀明, 増田英隆, 他:細胞内ATP量を指標とした制癌剤感受性試験 (ATP法). 癌と化学療法 13:2342-2345, 1986.
Medical*Online

Session 脳I

P.289 掲載の参考文献
1) Onodera H, et al:Lesions to Schaffer collaterals prevent ischemic death of CA1 pyramidal cells. Neurosci. Lett. 68:169-174, 1986.
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2) Onodera H, et al:Protein kinase C activity in the rat hippocampus after forebrain ischemia; autoradiographic analysis by[3H]phorbol 12, 13-dibutyrate. Brain Res. 481:1-7, 1989.
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3) Onodera H, et al:Mapping second messenger systems in the rat hippocampus after transient forebrain ischemia;in vitro[3H]forskolin and[3H]inositol 1, 4, 5-trisphosphate binding. Brain Res. 487:343-349, 1989.
PubMed
P.297 掲載の参考文献
1) Farber JL:The role of calcium in cell death. Life Sci. 29:1289-1295, 1981.
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2) Dienel GA:Regional accumulation of calcium in postischemic rat brain. J. Neurochem. 43:913-925, 1984.
 
3) Raichle ME:The phathophysiology of brain ischemia. Annu. Neurol. 13:2-10, 1983.
 
4) Simon RP, Griffiths T, Evans MC, et al:Calcium overload in selectively vulnerable neurons of the hippocampus during and after ischemia:An electron microscopy study in the rat. J. Cereb. Blood Flow Metab. 4:350-361, 1984.
 
5) Welsh FA, Reider W:Evaluation of in situ freezing of cat brain by NADH fluorescence. J. Neurochem. 31:299-309, 1978.
 
6) Csiba L, Paschen W, Hossmann KA:A topographic quantitative method for measuring brain tissue pH under physiological and pathophysiological conditions. Brain Res. 289:334-337, 1983.
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7) Kobayashi S, Kikuchi H, Ishikawa M, et al:Histochemical representation of regional ATP in the brain using a firefly luciferase-immobilized membrane in a multilayer film format. J. Cereb. Blood Flow Metab. 9:563-570, 1989.
 
8) Kogure K, Alonso OF:Apictorial representation of endogenous brain ATP by a bioluminescent method. Brain Res. 154:273-284, 1978.
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9) Bodensteiner JB, Engel AG:Intracellular calcium accumulation in Duchenne dystrophy and other myopathies:A study of 567,000 muscle fibers in 114 biopsies. Neurol. 28:439-446, 1978.
 
10) Mulryan BJ, Neuman MW, Neuman WF, et al:Equilibration between tissue calcium and injected radiocalcium in the rat. Am. J. Physiol. 207:947-952, 1964.
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11) Bouldin TW, Krigman MR:Differential permeability of cerebral capillary and choroid plexus to lanthanum ion. Brain Res. 99:444-448, 1975.
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12) Murphy VA, Smith QR, Rapoport SI:Homeostasis of brain and cerbrospinal fluid calcium concentration during chronic hypo-and hypercalcemia. J. Neurochem. 47:1735-1741, 1986.
 
13) Hansen AJ, Zeuthen T:Extracellular ion concentrations during spreading depression and ischemia in the rat brain cortex. Acta Physiol. Scand. 113:437-445, 1981.
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14) 石川正恒, 小林修一:脳虚血におけるカルシウムホメオスターシスと神経伝達物質. 医学のあゆみ 149:734-737, 1989.
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15) Ito U, Spatz M, Walker JT, et al:Experimental cerebral ischemia in Mongolian gerbils. I. Light microscopic observations. Acta Neuropath. (Berl) 32:209-223, 1975.
 
P.306 掲載の参考文献
1) Hanahan DJ, Demopoulos CA, Liehr J, et al:Identification of platelet activating factor isolated from rabbit basophils as acetyl glyceryl ether phosphorylcholine. J. Biol. Chem. 255:5514-5516, 1980.
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2) Hanahan DJ:Platelet activating factor:a biologically active phosphoglycerides. Ann. Rev. Biochem. 55:483-509, 1986.
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3) Farr RS, Wardlow ML, Cox CP, et al:Human serum acid-labile factor is an acylhydrolase that inactivates platelet-activating factor. Fed. Proc. 42:3120-3122, 1983.
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4) 井上圭三:炎症と血小板活性化因子. 代謝 23:891-899, 1986.
 
5) 和久敬蔵:血小板活性化因子. 代謝 24:625-639, 1987.
 
6) Chignard M, Le Couedic Jp, Tence M, et al:The role of platelet-activating factor in platelet aggregation. Nature 179:799-800, 1979.
 
7) Couch JR, Hassaneis SM:Platelet aggregation, stroke, transient ischemic attack in middleaged and elderly patients. Neurology 26:888-895, 1976,
 
8) Landi G, D'Angelo A, Boccardi E, et al:Hypercoagulability in acute stroke:prognostic significance. Neurology 37:1667-1671, 1987.
 
9) Craddock PR, Hammerschmidt D, White JG, et al:Complement (C5a)-induced granulocyte aggregation in vitro. A possible mechanism of complement-mediated leukostasis and leukopenia. J. Clin. Invest. 60:260-264, 1977.
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10) Boyum A:Isolation of mononuclear cells and granulocytes from human blood. Scand. J. Clin. Lab. Invest. 21 (Suppl. 97):77-89, 1968.
 
11) Terashita A, Tsushima S, Yoshioka Y, et al:CV-3988-a specific antagonist of platelet-activating factor. Life Sci. 32:1975-1982, 1983.
 
12) Stafforini DM, Prescott SM, McIntyre TM:Human plasma platelet-activating factor acetyl-hydrolase. Purification and properties. J. Biol. Chem. 262:4223-4230, 1987.
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13) Marcus AJ, Safier LB, Ullman HL, et al:Effects of acetyl glyceryl ether phosphorylcholine on human platelet function in vitro. Blood 58:1027-1031, 1981.
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14) McIntyre TM, Zimmerman GA, Satoh K, et al:Cultured endothelial cells synthesize both platelet-activating factor and prostacyclin in response to histamine, bradykinin and adenosine triphosphate. J. Clin. Invest. 76:271-280, 1985,
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15) 佐藤 敬, 高松 滋, 今泉忠淳, 他:内皮細胞障害と血小板活性化因子 (PAF) の産生. 日本臨牀 46:552-557, 1985.
 
16) Zimmerman GA, McIntyre TM, Prescott SM:Thrombin stimulates the adherence of neutrophils to human endothelial cells in vitro. J. Clin. Invest. 76:2235-2246, 1985.
PubMed
17) Lynch JM, Henson PM:The intracellular retention of newly synthesized platelet-activating factor. J. Immunol. 137:2653-2661, 1986.
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18) Ernst E, Matrai A, Paulsen F:Leukocyte rheoiogy in recent stroke. Stroke 18:59-62, 1987.
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19) Caramelo C, Fernandez-Gallardo S, Morin-Cao D, et al:Presence of platelet-activating factor in blood from humans and experimental animals. Its absence in anephric individuals. Biochem. Biophys. Res. Commun. 120:789-796, 1984.
 
20) Smith KA, Prewitt RL, Byers LW, et al:Analogs of phosphatidylcholine:α-adrenergic antagonists from the renal medulla. Hypertension 3:460-470, 1981.
 
21) Grandel KE, Farr RS, Wanderer AA, et al:Asociation of platelet-activating factor with primary acquired cold urticaria. New Engl. J. Med. 313:405-409, 1985.
 
22) Lazanas M, Demopoulos CA, Tournis S, et al:PAF of biological fluids in disease:I. V. levels in blood in allergic reactions induced by drugs. Arch. Dermatol. Res. 280:124-126, 1988.
 
23) Doebber TW, Wu MS, Robbins JC, et al:Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. Studies with PAF-receptor antagonist kadsurenone. Biochem. Biophys. Res. Commun. 127:799-808, 1985.
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24) 今泉忠淳, 佐藤 敬, 吉田秀見, 他:喫煙による血漿中への platelet-activating factor (PAF) 様脂質の放出. 医学のあゆみ 149:665-666, 1989.
 
25) Satoh K, Imaizumi T, Kawamura Y, et al:Activity of platelet-activating factor (PAF) acetylhydrolase in plasma from patients with ischemic cerebrovascular disease. Prostaglandins 35:685-698, 1988.
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P.315 掲載の参考文献
1) Dunwiddie TV:Endogenously released adenosine regulates excitability in the in vitro hippocampus. Epilepsia 21:541-548, 1980.
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2) 新居康夫, 森本一良, 早川 徹, 他:微小透析法によるてんかん実験model-脳波所見とpurine代謝物の観察-. 医学のあゆみ 146:863-864, 1988.
 
3) Dragunow M:Adenosine:the brain's natural anticonvulsant? Trends, Pharmacol. Sci. 7:128-130, 1986.
 
4) Dragunow M, Goddard GV, Laverty A:Proconvulsant effects of theophylline on hippocampal afterdischarges. Exp. Neurol. 96:732-735, 1987.
 
5) Dragunow M, Robertson HA:8-Cyclo-pentyl 1.3-dimethylxanthine prolongs epileptic seizures in rats. Brain Res. 417:377-379, 1987.
 
6) Dragunow M, Faull RLM:Neuroprotective effects of adenosine. Trends Pharmacol. Sci. 9:193-194, 1988.
 
7) 清水洋良, 森本一良, 嶋田延光, 他:微小透析法による脳組織間質液中 S-adenosyl-L-methionine の動態に関する基礎的研究. 脳神経 40:1163-1168, 1988.
 
8) Morimoto K, Tagawa K, Hayakawa T, et al:Cellular level of purine compounds in ischemic gerbil brain by high performance liquid chromatography. J. Neurochem. 38:833-835, 1982.
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9) Freeman AR:Polyfunctional role of glutamic acid in excitatory synaptic transmission. Prog. Neurobiol. 6:137-153, 1976.
 
10) 佐藤崇志, 森 則夫, 熊代 永:興奮性アミノ酸の相乗作用を利用したてんかん性けいれんモデル. 脳神経 40:747-751, 1988.
 
11) Hagberg H, Andersson P, Butcher S, et al:Blockade of N-methyl-D-aspartate-sensitive acidic amino acid receptors inhibits ischemia-induced accumulation of purine catabolites in the rat striatum. Neurosci. Lett. 68:311-316, 1986.
 
12) Hagberg H, Andersson P, Lacarewics J, et al:Extracellular adenosine, inosine, hypoxanthine, and xanthine in relation to tissue nucleotides and purines in rat striatum during transient ischemia. J. Neurochem. 49:227-231, 1987.
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13) 正名好之, 森本一良, 早川 徹, 他:脳虚血における脳内purine作動性物質の動態-脳微小透析法と脳組織抽出法との比較検討. 脳神経 41:687-693, 1989.
 
14) Winn HR, Welsh JE, Rubio R, et al:Changes in brain adenosine during bicuculline-induced seizures in rats. Effects of hypoxia and altered systemic blood pressure. Circ. Res. 47:568-577, 1980.
PubMed
15) Goodman RR, Snyder SH:Autoradiographic localization of adenosine receptors in rat using (3H) cyclohexyladenosine. J. Neurosci. 2:1230-1241, 1982.
 
16) Halpain S, Parsons B, Rainbow TC:Tritium-film autoradiography of sodium-independent glutamate binding site in rat brain. European J. Pharmacol. 86:313-314, 1983.
 
17) Pinel PJ, Rovner LI:Experimental epileptogenesis;kindling-induced epilepsy in rats. Exp. Neurol. 58:111-121, 1978.
 
18) Dunwiddie TV, Worth T:Sedative and anticonvulsant effect of adenosine analogs in mouse and rat. J. Pharmacol. Exp. ther. 220:70-76, 1982.
 
19) Phillis JW, Wu PH:The role of adenosine and its nucleotides in central synaptic transmission. Prog. Neurobiol. 16:187-239, 1981.
PubMed
20) Rosen JB, Berman RF:Differential effects of adenosine analogs on amygdala, hippocampus, and caudate nucleus kindled scizures. Epilepsia 28:658-666, 1987.
 

Session 脳II

P.328 掲載の参考文献
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2) 島津邦男:脳血管障害と自律神経障害. 診断と治療 75:1965-1969, 1987.
 
3) Meyer JS, Shimazu K, Fukuuchi Y, et al:Impaired neurogenic cerebrovascular control and dysautoregulation after stroke. Stroke 4:169-186, 1973.
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4) 渡辺 孝, 弥政洋太郎, 阿部稔雄, 他:循環遮断法における幼牛血液抽出物 (Solcoseryl) の脳保護作用. 日低温会誌 3:27-31, 1983.
 
5) Quadbeck G, Claver B, Minet G, et al:Einfluβ von Stimulantien und Antidepressiva auf das Hoehen-EEG der Ratte. Arzneim-Forsch 14:563-565, 1965.
 
6) SOLCOSERYL 脳血管障害研究会:脳血管障害に対するSolcoseryl の二重盲検法による薬効評価. 基礎と臨床 12:311-343, 1978.
 
7) Holmes RL, Wolstencroft JH:Accessory sources of blood supply to the brain of the cat. J. Physiol. 148:93-107, 1959.
 
8) 大久保毅, 島津邦男, 丸木雄一, 他:自律神経反射に対する Anoxia の影響に関する基礎的研究. (会) 自律神経 25:209-210, 1988.
 
9) Domopouls HB, Flamm ES, Pietronigro DD, et al:The free radical pathology and the microcirculation in the major central nervous system disorders. Acta Physiol. Scand. 492 (Suppl.):91-119, 1980.
 
10) Siesjo BK:Cell damage in the brain;a speculative synthesis. J. Cereb. Blood Flow Metabo. 1:155-185, 1981.
 
11) 内海耕慥, 高橋聖一, 山本博文, 他:多核白血球の0;生成に対するソルコセリルの作用. Cyto-protection 1:biology 1:131-139, 1983.
 
12) 杉山憲嗣, 龍 浩志, 上村研一, 他:Mongolian gerbilにおける一時的脳虚血後のMDA変化に関する研究. Cyto-pro tection 8 biology 5:161-167, 1987.
 
P.336 掲載の参考文献
1) 武田雅俊, 多田國利, 播口之朗, 他:実験的原線維変化を生じた家兎脳およびアルツハイマー病脳におけるカテプシンD活性の変化と線維性蛋白質. 神経化学 23:180-182, 1984.
 
2) Suzuki H, Takeda M, Nakamura Y, et al:Activities of lysosomal enzymes in rabbit brain with experimental neurofibrillary changes. Neurosci. Lett. 89:234-239, 1988.
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3) Suzuki H, Takeda M, Nakamura Y, et al:Neurofilament degradation by bovine brain cathepsin D. Neurosci. Lett. 89:240-245, 1988.
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4) Matus A, Green GDJ:Age-related increase in a cathepsin D like protease that degrades brain microtuble associated proteins. Biochem. 26:8083-8086, 1987.
 
5) Nakamura Y, Takeda M, Suzuki H, et al:Lysosome instability in aged rat brain. Neurosci. Lett. 97:215-220, 1989.
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6) Yamamoto K, Katsuda N, Kato K:Affinity purification and properties of cathepsin E like acid protease from rat spleen. Eur. J. Biochem. 92:499-508, 1978.
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7) Fishmann WH, Green S:Enzymatic catalysis of grucuronyl transfer J. Biol. Chem. 225:435-452, 1957.
 
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9) Ignaro LJ:Effects of anti-inflamatory drugs on the stability of rat liver lysosomes in vitro. Biochem. Pharmac. 20:2847-2860, 1971.
 
10) Goldman R, Kaplan A:Ruputure of rat liver lysosomes mediated by 1-amino acid esters. Biochim. Biophys. Acta 318:205-216, 1973.
 
11) Schneider DL:The acidification of rat liver lysosome in vitro;arole for the membranous ATPase as a protonn pump. Biochim. Biophys. Res. Commun. 87:559-565, 1979.
 
12) Witaker JN, Terry LC, Whestsell WO Jr:Immunocytochemical localization of cathepsin D in rat neural tissue. Brain Res. 216:109-124, 1981.
 
13) Nakamura Y, Takeda M, Suzuki H, et al:Age-dependent change in activities of lysosomal enzymes in rat brain. Mech. Ageing Dev. (in press)
 
14) 中村 祐, 武田雅俊, 鈴木英夫, 他:脳ライソゾームに対するアルミニウムの作用. 神経化学 27:222-223, 1988.
 
P.344 掲載の参考文献
1) Browder J, Rabiner AM:Regional swelling of the brain in subdural hematoma. Ann. Surg. 134:369-375, 1951.
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2) Cook AW, Browder J, Carter WB:Cerebral swelling and ventricular alterations following evacuation of intracranial extradural hematoma. J. Neurosurg. 19:419-423, 1962.
 
3) 貫井英明, 相羽 正:慢性硬膜下血腫における脳循環動態. 脳神経外傷 4:371-382, 1972.
 
4) 池田清延, 加納昭彦, 早瀬秀男, 他:慢性硬膜下血腫における臨床症状と血腫量および局所脳血流量の関係. 神経外科 24:869-875, 1984.
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5) 上田幹也, 高橋義男, 大宮信行, 他:慢性硬膜下血腫における Single Photon Emission CT 所見. CT研究 7:623-630, 1985.
 
6) 福田忠治, 池田裕介, 永井恭介, 他:老人期慢性硬膜下血腫の検討-臨床症状, CT所見, 頭蓋内圧および脳血流量の関連から-. 神経外傷 9:55-61, 1986.
 
7) 瀬川 弘, 藤江和貴, 藤巻高光, 他:慢性硬膜下血腫の脳血流量と脳機能-灰白質と白質の差異について-. 日本脳神経外科学会総会抄録集 (第45回). 1986, p. 350.
 

Session フリーラジカルI

P.354 掲載の参考文献
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PubMed
2) Shigeta Y, Nomura F, Iida S, et al:Ethanol metabolism in vivo by the microsomal ethanol-oxidizing system in deermice lacking alcohol dehydrogenase (ADH). Biochem. Pharmacol. 33:807-814, 1984.
PubMed
3) Alderman J, Takagi T, Lieber CS:Ethanol-metabolizing pathways in deermice:Estimation of flux calculated from isotope effects. J. Biol Chem. 262:7497-7503, 1987.
PubMed
4) Krikun G, Cederbaum AI:Effect of chronic ethanol consumption on microsomal lipid peroxidation. FEBS Lett. 208:292-296, 1986.
PubMed
5) Shaw S, Jayatilleke E, Lieber CS:Lipid peroxidation as a mechanism of alcoholic liver injury:Role of iron mobilization and microsomal induction. Alcohol 5:135-140, 1988.
PubMed
6) Aust SD, Roerig DL, Pederson TC:Evidence for superoxide generation by NADPH-cytochrome c reductase of rat liver microsomes. Biochem. Biophys. Res. Com. 47:1133-1137, 1972.
PubMed
7) Cederbaum AI, Dicker E, Rubin E, et al:The effect of dimethylsulfoxide and other hydroxyl radical scavengers on the oxidation of ethanol by rat liver microsomes. Biochem. Biophys. Res. Com. 78:1254-1262, 1977.
PubMed
8) Ohnishi K, Lieber CS:Respective role of superoxide and hydroxyl radical in the activity of the reconstituted microsomal ethanol-oxidizing system. Arch. Biochem. Biophys. 191:798-803, 1978.
PubMed
9) Krikun G, Lieber CS, Cederbaum AI:Increased microsomal oxidation of ethanol by cytochrome P-450 and hydroxyl radical-dependent pathways after chronic ethanol consumption. Biochem. Pharmacol. 33:3306-3309, 1984.
PubMed
10) Ingelman-Sundberg M, Johansson I:Mechanisms of hydroxyl radical formation and ethanol oxidation by ethanol-inducible and other forms of rabbit liver microsomal cytochrome P-450. J. Chem. 259:6447-6458, 1984.
 
11) Cederbaum AI, Dicker E:Inhibition of microsomal oxidation of alcohols and of hydroxyl-radical scavenzing agents by the iron-chelating agent desferrioxamine. Biochem. J. 210:107-113, 1983.
PubMed
12) Sinaceur J, Ribiere C, Abu-Murad C, et al:Reduction in the rate of ethanol elimination in vivo by desferrioxamine and diethylenetriamine-pentaacetic acid:suggestion for involvement of hydroxyl radicals in ethanol oxidation. Biochem. Pharmacol. 32:2371-2373, 1983.
PubMed
13) Reinke LA, Lai EK, DuBose CM, et al:Reactive free radical generation in vivo in heart and liver of ethanol-fed rats:Correlation with radical formation in vitro. Proc. Natl. Acad. Sci. USA. 84:9223-9227, 1987,
PubMed
14) Albano E, Tomasi A, Goria-Gatti L, et al:Spin trapping of free radical species produced during the microsomal metabolism of ethanol. Chem. Biol. Interactions 65:223-234, 1988.
PubMed
15) Boveris A, Cadenas E, Reiter R, et al:Organ chemiluminescence:Noninvasive assay for oxidative radical reactions. Proc. Natl. Acad. Sci. USA. 77:347-351, 1980.
PubMed
16) Boveris A, Fraga CG, Varsavsky AI, et al:Increased chemiluminescence and superoxide production in the liver of chronically ethanol-treated rats. Arch. Biochem. Biophys. 227:534-541, 1983,
PubMed
17) Puntarulo S, Cederboum AI:Chemiluminescence studies on the generation of oxygen radical from the interaction of NADPH-cytochrome P-450 reductase with iron. Arch. Biochem. Biophys. 258:510-518, 1987.
 
18) Lieber CS, DeCarli LM:Liquid diet technique of ethanol administration:1989 update. Alc. Alcoholism 24:197-211, 1989.
 
19) Omura T, Sato R:The carbon mono-xide-binding pigment of liver microsomes. J. Biol. Chem. 239:2370-2385, 1964.
 
20) Lowry OH, Rosenbrough NJ, Farr AI, et al:Protein measurement with the folin phenol reagent. J. Biol. Chem. 193:265-275, 1951.
 
21) Nakano M, Noguchi T, Sugioka K, et al:Spectroscopic evidence for the generation of singlet oxygen in the reduced nicotinamide adenine dinucleotide phosphate-dependent microsomal lipid peroxidation system. J. Biol. Chem. 250:2404-2406, 1975.
PubMed
22) Sugioka K, Nakano M:A possible mechanism of the generation of singlet oxygen in NADPH-dependent microsomal lipoperoxidation. Biochim. Biophys. Acta 423:203-216, 1976.
 
23) 伊藤大輔, 高木俊和, 石井裕正, 他:肝ミクロソームのエタノール代謝と活性酸素産生に関する実験的検討. Cyto-protection & biology 6:401-407, 1988.
 
24) Nakano M, Sugioka K, Ushijima Y, et al:Chemiluminescence probe with Cypridina luciferin analog, 2-methyl-6-phenyl-3, 7-dihydroimidazo[1,2-a]pyrazin-3-one, for estimating the ability of human granulocytes to generate O-2. Anal. Biochem. 159:363-369, 1986.
 
25) Sugioka K, Nakano M, Kurashige S, et al:A chemiluminescent probe with a Cypridina luciferin analog, 2-methy-6-phenyl-3, 7-dihydroimidazo[1, 2-a]pyrazin-3-one, specific and sensitive for O2 i production in phagocytizing macro-phages. FEBS Lett. 197:27-30, 1986.
 
26) Puntarulo S, Cederbaum AI:Effect of oxygen concentration on microsomal oxidation of ethanol and generation of oxygen radicals. Biochem. J. 251:787-794, 1988.
PubMed
P.363 掲載の参考文献
1) Gross RL, Newberne PM:Role of nutrition in immunologic function. Physiol. Rev. 60:188-302, 1980.
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2) Ross MH:Length of life and caloric intake, Am. J. Clin. Nutr. 25:834-838, 1972.
PubMed
3) Kubo C, Day NK, Good RA:Influence of early or late dietary restriction on life span and immunological parameters in MRL/Mp-lpr/lpr mice. Proc. Natl. Acad. Sci. USA. 81:5831-5835, 1984.
PubMed
4) 細川友秀, 六反一仁, 吉田明子, 他:MRLマウスの加齢に伴う免疫能の低下と自己抗体産生に及ぼす蛋白制限の効果, 消化器と免疫. No. 19, 日本医学館, 東京, 1987, pp. 271-275.
 
5) 青池 晟, 細川友秀, 吉田明子, 他:栄養環境の消化器局所免疫能への影響. 消化器と免疫. No. 22, 日本医学館, 東京, 1989, pp. 43-46.
 
6) Sanchez SG, Wulff J:Mechanisms of nutrition and stress-induced changes on immune function. Am. J. Med. 76:A87, A97, 1984.
 
7) Rokutan K, Hosokawa T, Nakamura K, et al:Increased superoxide anion production and glutathione peroxidase activity in peritoneal macrophages from auto immune-prone MRL/Mp-lpr/lpr mice. Int. Arch. Allergy Appl. Immunol 87:113-119, 1988.
 
8) Johnston RB Jr:Measurement of O 2 secreted by monocytes and macrophages. Meth. Enzymol. 105:365-369, 1984.
 
9) Hara C, Manabe K, Ogawa N:Influence of activity-stress on thymus, spleen and adrenal weights of rats;possibility for an immunodeficiency model. Physiol. Behav. 27:243-248, 1981.
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10) Selye H:A syndrome produced by diverse nocuous agents. Nature 148:84-85, 1936.
 
11) Syvalahti E:Endocrine and immune adaptation in stress. Ann. Clin. Res. 19:70-77, 1987.
 
12) Landmann RA, Muller FB, Perini CH, et al:Changes of immunoregulatory cells induced by psychological and physical stress;relationship to plasma catecholamines. Clin. Exp. Immunol. 58:127-135, 1984.
 
13) Deitch EA, Bridges RM:Stress hormones modulate neutrophil and lymphocyte activity in vitro. J. Trauma 27:1146-1154, 1987.
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14) 久保千春, 手嶋秀毅, 吾郷晋浩, 他:免疫機能に及ぼす絶食の影響. 心身医 22:250-254, 1982.
 
15) Wing EJ, Barczynski LK, Boehmer SM:Effect of acute nutritional deprivation on immune function in mice. I. Macrophages. Immunol. 48:543-550, 1983.
 
16) Wing EJ, Stanko RT, Winkelstein A, et al:Fasting-enhanced immune effector mechanisms in obese subjects. Am. J. Med. 75:91-96, 1983.
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17) Palmblad J, Cantell K, Holm G, et al:Acute energy deprivation in man;effect on serum immunoglobulins antibody response, complement factors 3 and 4, acute phase reactants and interferon-producing capacity of blood lymphocytes. Clin. Exp. Immunol. 30:50-55, 1977.
PubMed
18) Azoulay-Dupuis E, Bouley G, Moreau J, et al:Evidence for humoral immunodepression in NO2-exposed mice;influence of food restriction and stress. Environ. Res. 42:446-454, 1987.
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19) 大沢伸昭:免疫・神経・内分泌相関に関する新しい研究展開. 特にサイトカインを中心に. 免疫薬理6:11-15, 1988.
 
20) Oppenheim JJ, Kovacs EJ, Matsushima K, et al:There is more than one interleukin 1. Immunol. Today 7:45-56, 1986.
PubMed
P.371 掲載の参考文献
1) Kaplow LS, Goffinet JA:Profound neutropenia during the early phase of hemodialysis. JAMA 41:293-298, 1968.
 
2) Craddock PR, Fehr J, Dalmasso AP, et al:Haemodialysis Leukopenia;pulmonary vascular leukostasis resulting from complement activation by dialyser cellophane membranes. J. Clin. Invest. 59:879-888, 1977.
PubMed
3) Jacob AI, Gravellas G, Zarco R, et al:Leukopenia, hypoxia, and complement function with different hemodialysis membranes. Kidney Int. 18:505-509, 1980.
 
4) Maher ER, Wickens DG, Griffin JFA, et al:Increased Free-Radical Activity During Haemodialysis. Nephrol. Dial. Transplant. 2:169-171, 1987.
 
5) Aijama P, Martin-Malo A, Castillo D, et al:Anaphylotoxin C5a generation and dialysis-induced leukopenia with different hemodialyzer membranes. Blood Purif 4:88-92, 1986.
 
6) Descamps-Latscha B:Phagocyte Oxidative Metabolism in Hemodialysis. Contr. Nephrol. 62:132-139, 1988.
 
7) Nishida A, Kimura H, Nakano M, et al:A sensitive and specific chemiluminescence method for estimating the ability of human granulocytes and monocytes to generate O2 E. Clin. Chimi. Acta 179:177-182, 1989.
 
8) 平沢敏昭, 大隅雅夫, 岩谷周一, 他:消化器外科手術前後の好中球05産生能の変動. 日本消化器外科学会誌 22:1943, 1989.
 
9) Uto J, Yamamoto T, Utsunomiya T, et al:Effect of surgery on neutrophil functions, superoxide and leukotriene production. Br. J Surg. 75:682-685, 1988.
 
10) 秋沢忠男:最近の透析機器. 臨床透析 1:397-405, 1985.
 
11) Giardini O, Taccone-Gallucci M, Lubrano R, et al:Evidence of Red Blood Cell Membrane Lipid Perioxidation in Haemodialysis Patients. Nephron. 36:235-237, 1984.
 
12) 三上祐司, 飯田喜俊, 白井大禄, 他:透析患者の血液粘度学的検討. 人工透析学会誌 11:47-48, 1978.
 
13) 長町幸雄, 平沢敏昭, 小井田時広, 他:急性胃粘膜病変と血液レオロジー. Cyto-protection & biology 2:135-143, 1984.
 
P.381 掲載の参考文献
1) Scharf J, Dovrat A:Superoxide dismutase molecules in human cataractous lenses. Ophthalmic Res. 18:332-337, 1986.
PubMed
2) Rao NA, Fernandez MAS, Cid LL, et al:Retinal lipid peroxidation in experimental uveitis.Arch. Ophthalmol. 105:1812-1816, 1987.
 
3) Rao NA, Romero JL, Fernandez MAS, et al:Role of free radical in uveitis. Surv. Ophthalmol. 32:209-213, 1987.
 
4) Rao NA, Sevanian A, Fernandez MAS, et al:Role of oxygen radicals in experimental allergic uveitis. Invest. Ophthalmol. Vis. Sci. 28:886-892, 1987.
 
5) Rao NA, Calandra AJ, Sevanian A:Modulation of lens-induced uveitis by superoxide dismutase. Ophthalmic. Res. 18:41-46, 1987.
 
6) Yagi K:Lipoperoxide level of the retina of chick embryo exposed to high concentration of oxygen. Clinica. Chimica. Acta 80:355-359, 1977.
 
7) Ando Y, Inoue M, Utsumi T, et al:Synthesis of acylated SOD derivatives which bind to biomembrane lipid surface and dismutate extra-cellular superoxide radicals. FEBS Lett. 240:216-220, 1988.
 
8) Kamata R, Matsumoto K, Okamura R, et al:The Serratial 56K protease as a major pathologic factor in Serratial keratitis. Clinical and experimental study. Opthalmology 92:1452-1459, 1985.
 
9) Onodera T, Kumagai S, Watanabe T, et al:Experimental rabbit corneal ring formation caused by bacterial endotoxin. Folia. Ophthalmol. Jpn. 36:1013-1018, 1985.
 
10) Langone JJ:Radioiodination by use of the Bolton-Hunter and related reagents. Meth. Enzymol. 70:221-227, 1979.
 
11) Uchiyama M, Mihara M:Determination of malondialdehyde precursor in tissues by thiobar-bituric acid test. Anal. Biochem. 86:271-278, 1979.
 
12) Hinson JM, Hutchison AA, Ogletree ML, et al:Effector granulocyte depletion on altered lung mechanics after endotoxemia in sheep. Respirat. Environ. Exercise Physiol. 55:92-96, 1983.
 
13) Sasaoka N:Overall distribution of substance P nerves in rat cornea. Invest. Ophthalmol. Vis. Sci. 25:351-356, 1984.
 
14) Mondino BJ, Brown SI, Rabin BS, et al:Alternate pathway activation of complement in a Proteus mirabilis ulceration of the cornea. Arch Ophthalmol. 96:1659-1661, 1978.
 
15) Sato E, Takahara Y, Sasaki J, et al:Selective inhibition of stimulation responses of neutrophils by membrane modulators. Cell Struct. Funct. 11:125-134, 1981.
 
P.390 掲載の参考文献
1) Sies H:生体の酸化的ストレス. 活性酸素と疾患 (井上正康監訳). 学会出版, 東京, 1988, pp. 1-8.
 
2) 中野 稔:活性酸素の消去. 活性酸素 (二木鋭雄, 島崎弘幸編). 医歯薬出版, 東京, 1987, pp. 64-85.
 
3) Karlsson K, Marklund SL:Extracellular superoxide dismutase in the vascular system of mammls. Biochem. J. 255:223-228, 1988.
 
4) 手島義雄:フロチノイド. 蛋白質核酸酵素 33:2987-2993, 1988.
 
5) Andrewes AG, Starr MP:(3r, 3'r)-astaxanthin from the phaffia rhodozyma. Phytochemistry 15:1009-1011, 1976.
 
6) Machilin KJ, Filipski R, Nelson J, et al:Effect of a prolonged vitamin E deficiency in the rat. J. Nutrition 107:1200-1208, 1977.
 
7) Utusmi K:Relation between mitochondrial swelling induced by inorganic phosphate and accumulation of 32P in mitochondrial fraction. Acta Med. Okayama 17:259-271, 1963.
 
8) Dodge JT, Mitchell C, Hanaham DJ:The preparation and chemical characteristics of hemoglobin-free ghosts of human ergthrocytes. Arch Biochem. Biophys. 100:119-130, 1963.
 
9) Aono K, Shiraishi N, Arita T, et al:Changes in mitochondrial function by lipid peroxidation and their inhibition by biscoclaurin alkaloid. Physiol. Clem. Phys. 13:137-144, 1981.
 
10) Buege JA, Aust ATD:Microsomal lipid peroxidation. Meth. Enzymol. 52:302-310, 1978.
 
11) Kates M:Techniques of lipidology. North-Holland, Am. Elseiver. 1972.
 
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13) Rosa MDI, Giroud JP, Willoughdy DA:Studies on the mediators of acute inflammatory responces induced in rats in different sites by carragenan and turpentine. J. Pathol. 104:15-29, 1971.
 
P.401 掲載の参考文献
1) Babior BM, Kipnes RS, Curnutte JT:Biological defence mechanisms. J. Clin. Invest. 52:741-744, 1973.
PubMed
2) Suematsu M, Suzuki M, Kitahora T:Increased respiratory burst of leukocytes in inflammatory bowel disease-The analysis free radical generation by using chemiluminescence probe. J. Chin. Lab. Immunol. 24:125-1258, 1987.
 
3) Frankel ENT, Neff WF:Formation of malonaldehyde from lipid peroxidation. In Free radicals in biology. Acad. Press, 1982, pp. 1-28.
 
4) Rutledge PL, Saluja AK, Stter ML:Role of oxygen-derived free radicals in diet-induced hemorrhagic pancreatitis in mice. Gastroenterol. 93:41-47, 1987.
 
5) Sanfey H, Bulkley GB, Cameron JL;The pathogenesis of acute pancreatitis. The source and role of oxygen-derived free radicals in three diferent experimental models. Ann. Surg. 201:633-639, 1985.
 
6) Sanfey H, Bulkley GB, Cameron JL:The role of oxygen-derived free radicals in the pathogenesis of acute pancreatitis. Ann. Sung. 200:405-413, 1984.
 
7) Kitagawa S, Takaku F, Sakamoto S:Evidence that proteases are involved in speroxide production by human polymorphonuclear leukocytes and monocytes. J. Clin. Invest. 65:74-81, 1979.
 
8) McCord JM, Fridovich I;Superoxide dismutase. J. Biol. Chem. 244:6049-6055, 1969.
PubMed
9) Root RK, Metcalf J, Oshino N:H202 release from human granulocytes during phagocytosis, J. Clin. Invest. 55:945-955, 1975.
 
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11) Hirata F, Hayaishi O:Studies on induleamine 2, 3-dioxygenase I. Superoxide anion as substrate. J. Biol. Chem. 250:5960-5966, 1975.
PubMed
12) Strobel HW, Coon MJ:Effect of superoxide generation and dismutation on hydroxylation reactions catalyzed by liver microsomal cytochrome P-450. J. Biol. Chem. 246:7827-7829, 1971,
 
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PubMed
15) Nakagawara M, Takeshige K, Sumimoto H:Superoxide-release and intracellular free calcium of calcium-depleted human neutrophils stimulated by formyl-methionyl-leucyl-phenylalanin. Biochem. Biol. Acta 805:97-103, 1984.
 
16) Wakeyama H, Takeshige K, Takayanagi R:Superoxide-forming NADPH oxidase preparation of pig polymorphonuclear leucocytes. J. Biochem. 205:593-601, 1982.
 

Session フリーラジカルII

P.414 掲載の参考文献
1) 門田俊夫, 入江敏之, 佐藤敬文, 他:ラット肝虚血モデルにおけるエンドトキシンならびに oxygen free radicalの検討. Cyto-protection & biology 5:193-199, 1987.
 
2) 黒江幸四郎, 野浪敏明, 佐竹 満, 他:部分肝虚血時のエネルギー代謝動態-ソリコセリルのATP保護作用について-. Cyto-protection & biology 6:245-252, 1988.
 
3) 山田謙慈, 魚住 徹, 吉原高志:脳虚血の細胞障害機構における遊離基生成の関与-幼牛血液抽出剤の投与効果よりみて-. Cyto-protection & biology 6:353-360, 1988.
 
4) 内海耕慥, 高橋聖一, 山本博文, 他:多形核白血球のO-2生成に対するソルコセリルの作用. Cyto-protection & biology 1:131-139, 1983.
 
5) 吉川敏一, 上田茂信, 高橋周史, 他:虚血再灌流による胃粘膜障害とフリーラジカル. 日消誌 (投稿中)
 
6) Miyagawa H, Yoshikawa T, Tanigawa T, et al:Measurement of serum superoxide dismutase activity by electron spin resonance. J. Clin. Biochem. Nutr. 5:1-7, 1988.
 
7) 谷川 徹, 吉川敏一, 宮川晴雄, 他:ESRを用いたヒト末梢血多形核白血球のsuperoxide産生能の測定とその臨床応用. 炎症 8:443-447, 1988.
 
8) 内藤裕二, 吉川敏一, 谷川 徹, 他:スピントラッピング法を用いたヒト末梢多形核白血球のスーパーオキシド産生能の測定-刺激剤の相違による検討-. 炎症 9:323-327, 1989.
Medical*Online
9) 谷川 徹, 吉川敏一, 内藤裕二, 他:各種物質とヒドロキシルラジカルとの反応性. ESRとフリーラジカル. 日本医学館, 東京, 1989, pp. 109-114.
 
10) Ohkawa H, Ohnishi N, Yagi K:Assay for lipid peroxides for animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95:351-358, 1979.
 
11) Gardner TJ, Stewart JR, Casale AS, et al:Reduction of myocardial ischemic injury with oxygen-derived free radical. Surgery 94:423-427, 1983.
PubMed
12) Granger DN, Rutili G, McCord JM:Superoxide radicals in feline intestinal ischemia. Gas-troenterol. 81:22-29, 1981.
 
13) Flamm ES, Demopoulos HB, Seligma ML, et al:Free radicals in cerebral ischemia. Stroke 9:445-447, 1978.
PubMed
14) Parks DA, Bulkley GB, Granger DN:Role of oxygen free radicals in shock, ischemia, and organ preservation. Surgery 94:428-432, 1983.
PubMed
15) 門田俊夫, 田口 順, 大崎裕子, 他:エンドトキシンによる肝並びに胃粘膜障害の発生と活性酸素.Cyto-protection & biology 6:409-416, 1988.
 
16) 中村 寿, 大田信介, 榊 三郎, 他:くも膜下出血実験犬における髄液および脳動脈壁中の過酸化脂質量とその消去系物質の経時的変化について. Cyto-protection & biology 6:361-368, 1988.
 
17) Wills ED:Lipid peroxide formation in microsomes, general considerations. Biochem. J. 113:315-324, 1969.
PubMed
18) McCord JM, Fridovich I:Superoxide dismutase. An enzymatic function for erythrocuprein (hemocuprin), J. Biol. Chem. 244:6049-6055, 1969.
 
19) Hernandes LA, Grisham BM, Twohig B, et al:Role of neutrophils in ischemia-reperfusion-induced microvascular injury. Am. J. Physiol. 253:H699-703, 1987.
 
20) 鈴木雅之, 末松 誠, 三浦総一郎, 他:急性胃粘膜病変形成時の活性酸素産生におけるxanthine oxidase系および好中球の役割. 日消誌 85:835-842, 1988.
 
21) Gutteridge JMC, Richmand R, Halliwell B:Oxygen free-radicals and lipid peroxidation:Inhibition by the protein caeruloplasmin. FEBS Lett. 112:269-272, 1980.
 
22) Graf E, et al:Phytic acid;Anatural antioxidant. J. Biol. Chem. 262:11647-11650, 1987.
 
P.422 掲載の参考文献
1) Brierley JB, Graham DI:Hypoxia and vascular disorders of the central nervous system. In Greenfield's Neuropathology (edited by Adams JH, Corsellis JAN, Duchen LW). Arnold, London, 1984, pp. 125-207.
 
2) Kirino T:Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res. 239:57-69, 1982.
 
3) Benveniste H, Drejer J, Schousboe A, et al:Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemic monitored by intracerebral microdialysis. Nuerochem. 43:1369-1374, 1984.
PubMed
4) Gill R, Foster AC, Woodruff GN:Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegenerative in the gerbils. J. Neurosci. 7:3343-3349, 1987.
 
5) Johansen FF, Jφrgensen MB, Diemer NH:Ischemic CA-1 pyramidal cell loss is prevented by preischemic colchicine destruction of dentate gyrus granule cells. Brain Res. 377:344-347, 1986.
 
6) Jφrgensen MB, Johansen FF, Diemer NH:Removal of the entorhinal cortex protects hippocampal CA-1 neurons from ischemic damage. . Acta Neuropathol. 73:189-194, 1987.
 
7) Simon RP, Swan JH, Griffiths T, et al:Blockage of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain. Science 226:850-852, 1984.
 
8) Alps BJ, Hass WK:The potential beneficial effect of nicardipine in a rat model of transient forebrain ischemia. Neurology 37:809-814, 1987.
 
9) Benveniste H, Jφrgensen MB, Diemer NH, et al:Calcium accumulation by glutamate receptor activation is involved in hippocampal cell damage after iscemia. Acta Neurol. Scand. 78:529-536, 1988.
 
10) Deshpande JK, Siesjo BK, Wieloch TJ:Calcium accumulation and neuronal damage in the rat hippocampus following cerebral ischemia. J. Cerebral Blood Flow Metabol. 7:89-95, 1987.
 
11) Izumiyama K, Kogure K:Prevention of delayed neuronal death in gerbil hippocampus by ion channel blockers. Stroke 19:1003-1007, 1988.
 
12) Simon RP, Griffith T, Evens MC, et al:Calcium overload in selective vulnerable neurons of the hippocampus during and after ischemia. J. Cereb. Blood Flow Metabol. 4:350-361, 1984.
 
13) Kiessling M, Dienel GA, Jacewicz M, et al:Portein synthesis in postischemic rat brain:A two dimensional electrophoretic analysis. J. Cereb. Blood Flow Metabol. 6:642-649, 1986.
 
14) Thilmann R, Xie Y, Kleihues P, et al:Persisitent inhibition of protein synthesis precedes delayed neuronal death in postischemic gerbil hippocampus. Acta Neuropathol. 71:88-93, 1986.
 
15) Imdahl A, Hossman KA:Morphometric evaluation of postischemic capillary perfusion in selectively vulnerable areas of gerbil brain. Acta Neuropathol. 69:267-271, 1986.
 
16) Yanagihara T, Yoshimine T, Morimoto K, et al:Immunohistochemical investigation of cerebral ischemia in gerbils. J. Neuropathol. Exp. Neurol. 44:204-215, 1985.
PubMed
17) Mitsumoto M, Yamamoto K, Homburger HA, et al:Early detection of cerebral ischemic damage and repair process in the gerbil by use of an immunohistochemical technique. Mayo Clin. Proc. 62:460-472, 1987.
 
18) Kitagawa K, Matsumoto M, Niinobe M, et al:Microtubule associated protein 2 as a sensitive marker for cerebral ischemic damage:Immunohistochemical investigation of dendritic damage. Neuroscience 31:401-411, 1989.
PubMed
19) Oda T, Akaike T, Hamamoto T, et al:Oxygen radicals in influenza-induced pathogenesis and treatment with pyran polymer-conjugated SOD. Science 224:974-976, 1989.
 
20) Kitagawa k, Matsumoto M, Oda T, et al:Protective effect of pyran-conjugated superoxide dismutase on experimental cerebral ischemia. In Medical, biochemical and chemical aspect of free radicals (edited by Hayaishi O, Niki E, Kondo M, et al). Elsevier Science Publishers, Amsterdam, 1989, pp. 655-658.
 
21) Matsumoto M, Hatakeyama K, Yamamoto K, et al:A combined method for measurement of cerebral blood flow and immunohistochemistry for investigation of cerebral ischemia. Brain Res. 424:231-238, 1978.
 
22) Siesjo BK, Bendek G, Koide T, et al:Influence of acidosis on lipid peroxidation in brain tissues in vitro. J. Cereb, Blood Flow Metabol. 5:253-258, 1985.
 
23) Kogure K, Watson BD, Busto R, et al:Potentiation of lipid peroxides by ischemia in rat brain. Neurochemical Res. 7:437-454, 1982.
 
24) Watson BD, Busto R, Goldberg WJ, et al:Lipid peroxidation in vivo induced by reversible global ischemia in rat brain. J. Neurochem. 42:268-274, 1984.
 
25) Cao W, Carney JM, Duchon A, et al:Oxygen free radical involvement in ischemia and reperfusion injury to brain. Neurosci. Lett. 88:233-238, 1988.
PubMed
26) Imaizumi S, Tominaga T, Uenohara H, et al:Initiation and propagation of lipid peroxidation in cerebral infarction models. Neurological Res. 8:214-220, 1986.
 
27) Cooper AJL, Pulsinelli WA, Duffy TE:Glutathione and ascorbate during ischemia and postischemic reperfusion in rat brain. J. Neurochem. 35:1242-1245, 1980.
 
28) Rehncrona S, Folbergrova J, Smith DS, et al:Influence of complete and pronounced incomplete cerebral ischemia and subsequent recirculation on cortical concentrations of oxidized and reduced glutathione in the rat. J. Neurochem. 34:477-486, 1980.
 
29) Abe K, Yoshida S, Watson B, et al:α一Tocopherol and ubiquinones in rat brain subjected to decapitation ischemia. Brain Res. 273:166-169, 1983.
 
30) Davis RJ, Bulkley GB, Traystman RJ:Role of oxygen-free radicals in focal cerebral ischemia. J. Cereb. Blood Flow Metab. 7 (Suppl. 1):S10, 1987.
 
31) Hall ED, Paraza KE, Braughler JM:21-aminosteroid lipid peroxidation inhibitor U74006F protects against cerebral ischemia in gerbils. Stroke 19:997-1002, 1988.
 
32) Hall ED, Yonkers PA:Attenuation of postischemic cerebral hypoperfusion by the 21-aminosteroid U74006F. Stroke 19:340-344, 1988.
 
33) Liu TH, Beckman JS, Freeman BA, et al:Polyethylene glycol-conjugated superoxide dismutase and catalase reduce ischemic brain injury. Am. J. Physiol. 256:H589-H593, 1989.
PubMed
34) Imaizumi S, Woolworth V, Fishman RA, et al:Superoxide dismutase activities and their role in focal cerebral ischemia. J. Cereb. Blood Flow Metab. 9 (Suppl. 1):S217, 1989.
 
35) Connor JA, Wadman WJ, Hockberger PE, et al:Sustained dendritic gradients of Ca2+induced by excitatory amino acids in CA1 hippocampal neurons. Science 240:649-653, 1988.
PubMed
36) Sanchez-Prieto J, Gonzalez P:Occurrence of a large Ca2+-independent release of glutamate during anoxia in isolated nerve terminals (synaptosomes). J. Neurochem. 50:1322-1324, 1988.
PubMed
37) Pellergin-Giampietro DE, Cherici G, Alesiani M, et al:Excitatory amino acid released from rat hippocampal slices as a consenquence of free-radical formation. J. Neurochem. 51:1960-1963, 1988.
 
38) Southorn PA, Powis G:Free radicals in medicine. I. Chemical nature and biological reactions. Mayo Clin. Proc. 63:381-389, 1988.
 
39) Imlay JA, Linn S:DNA damage and oxygen radical toxicity. Science 240:1302-1309, 1988.
PubMed
P.430 掲載の参考文献
1) Suzuki S, Isshiki N, Ogawa Y, et al:The minimal requirement of circulation for survival of undelayed and delayed flaps in rats. Plast. Reconstr. Surg. 78:221-226, 1986.
PubMed
2) 鈴木茂彦, 一色信彦, 林 修, 他:低分子デキストランのウサギ皮弁血流におよぼす効果-電解式水素ガスクリアランス法によるモニタリング. 日形会誌 6:907-912, 1986.
 
3) Suzuki S, Isshiki N, Ogawa Y, et al:Effect of intravenous prostaglandin E1 on the experimental flaps. Ann. Plast. Surg. 19:49-53, 1987.
 
4) Burton KP:Superoxide dismutase enhances recovery following myocardial ischemia. Am. J. Physiol. 246:H637-643, 1985
 
5) Flamm ES, Demopoulos HB, Seligman ML, et al:Free radicals in cerebral ischemia. Stroke 9:445-447, 1978.
PubMed
6) Granger DN, Rutili G, McCord JM:Superoxide radicals in feline intestinal ischemia. Gastroenterol. 81:22-29, 1981.
 
7) McCord JM:Oxygen-derived radicals; a link between reperfusion injury and inflammation. Fed. Proc. 46:2402-2406, 1987.
PubMed
8) Sanfey H, Bulkley GB, Cameron JL:The pathogenesis of acute pancreatitis. The source and role of oxygen-derived free radicals in three different experimental models. Ann. Surg. 201:633-639, 1985.
PubMed
9) Manson PN, Anthenelli RM, Im MJ, et al:The role of oxygen-free radicals in ischemic tissue injury in island skin flaps. Ann. Surg. 198:87-90, 1983.
PubMed
10) Sagi A, Ferder M, Levens D, et al:Improved survival of island flaps after prolonged ischemia by perfusion with superoxide dismutase. Plast. Reconstr. Surg. 77:639-642, 1986.
PubMed
11) Im MJ, Shen WH, Pak CJ, et al:Effect of allopurinol on the survival of hyperemic island skin flaps. Plast. Reconstr. Surg. 73:276-278, 1984.
PubMed
12) Narayan KK, Im MJ, Manson PN, et al:Mechanism and prevention of ischemia/reperfusion injury in island skin flaps. Surg. Forum. 36:593-595, 1985.
 
13) Manson PN, Narayan KK, Im MJ, et al:Improved survival in free skin flap transfers in rats. Surg. 99:211-215, 1986.
PubMed
14) Im MJ, Manson PN, Bulkley GB, et al:Effects of superoxide dismutase and allopurinol on the survival of acute island skin flaps. Ann. Surg. 201:357-359, 1985.
PubMed
15) Angel MF, Narayanan K, Swartz WM, et al:Deferoxamine increases skin flap survival:Additional evidence of free radical involvement in ischemic flap surgery. Br. J. Plast. Surg. 39:469-472, 1986.
 
16) Angel MF, Ramasastry SS, Swartz WM:The critical relationship between free radicals and degrees of ischemia:Evidence for tissue intolerance of marginal perfusion. Plast. Reconstr. Surg. 81:233-239, 1988.
PubMed
17) Suzuki S, Miyachi Y, Niwa Y, et al:Significance of reactive oxygen species in distal flap necrosis and its salvage with liposomal SOD, Br. J. Plast. Surg. 42:559-564, 1989.
PubMed
18) Angel MF, Narayanan K, Swartz WM, et al:The etiologic role of free radicals in hematoma induced flap necrosis. Plast. Reconstr. Surg. 77:795-801, 1986.
PubMed
19) Angel MF, Haddad J, Abramson M:A free radical scavenger reduces hematoma induced flap necrosis in Fischer rats. J. Otolaryngol. Head Neck Surg. 96:96-98, 1987.
 
20) McCord JM, Roy RS:The pathophysiology of superoxide:Roles in inflammation and ischemia. Can. J. Physiol. Pharmacol. 601:1346-1352, 1982.
 
21) McCord JM:Oxygen-derived free radicals in postischemic tissue injury. New Eng. J. Med. 312:159-163, 1985.
PubMed
22) 鈴木茂彦, 吉岡伸高, 宮地良樹, 他:Epoxysuccinyl derivatives (E-64c) による島状皮弁における虚血再灌流障害予防効果について. 形成外科:(印刷中)
 
23) Harashina T, Sawada Y, Watanabe S:The relationship between various occlusion time in island flaps and flap survivals. Plast, Reconstr. Surg. 60:92-95, 1977.
PubMed
P.441 掲載の参考文献
1) McCord JM:Oxygen-derived free radicals in post-ischemic tissue injury. New Engl. J. Med. 312 (3):159-163, 1985,
 
2) Markland SL:Oxygen toxicity and protective systems. Clin. Toxicology 23 (4-6):289-298, 1985.
 
3) Clark IA:Tissue damage caused by free oxygen radicals. Pathology 18:181-186, 1986.
PubMed
4) Bass DA, Parce JW, Dechatelet LR, et al:Flow cytometric studies of oxdative product formation by neutrophils-A graded response of membrane stimulation. J. Immunol. 130 (4):1910-1917, 1983.
 
5) 大崎 饒, 入江 正:換気-血流関係の不均衡の原因およびその結果-シャント-. 呼吸機能検査トレーニング. 第一版, 中外医学社, 東京, 1983, pp. 86-91.
 
6) 錦織浩二, 前野弘夫:医薬品としてのグルタチオン. 蛋白質核酸酵素 33 (9):1625-1631, 1988.
 
7) 湯佐祚子:Free radical scavengerと肺疾患. Annual Review, 呼吸器:79-87, 1988.
 
8) Dawson JR, Vahakangas K, Jernstron B, et al:Glutathione conjugation by isolated lung cell and isolated, perfused lung-effect of extracellular glutathione. Eur. J. Biochem. 138:439-443, 1984.
 
9) McCord JM, Fridovich I:SOD an enzimic function for erythrocuprein. J. Biol. Chem. 25:6049-6055, 1969.
 
10) 内海耕慥, 高橋聖一, 山本博文, 他:多核白血球の05生成に対するソルコセリルの作用. Cyto-protection & biology 1:131-139, 1983.
 
11) 高橋久雄, 石井裕正, 永田茂之, 他:実験的四塩化炭素肝障害における過酸化脂質及び関連酵素の検討. Cyto-protection & Biology 2:27-33, 1984.
 
12) 角田俊夫, 入江敏之, 佐藤敬文, 他:ラット肝虚血モデルにおけるエンドトキシンならびに oxygen free radicalの検討. Cyto-protection & biology 5:193-199, 1987.
 
13) 内藤裕二, 吉川敏一, 谷川 徹, 他:ソルコセリルのスーパーオキサイド消去能と多形核白血球スーパーオキサイド産生に及ぼす影響. 医学のあゆみ 147 (3):215-216, 1988.
Medical*Online
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Medical*Online
15) Hess ML, Rowe GT, Caplan M, et al:Identification of hydrogen peroxide and hydroxyl radicals as mediators of leukocyte-induced myocardial dysfunction. Adv. Myocardiol 5:159-175, 1985.
PubMed
P.450 掲載の参考文献
1) Ohkawa H, Ohishi N, Yagi K:Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95:351-358, 1979.
PubMed
2) Ukikusa M, Ida T, Ozawa K, et al:The influence of hypoxia and hemorrhage upon adenylate energy charge and bile flow. S. G. O. 149:346-352, 1979.
 
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4) Marubayashi S, Dohi K, Ezaki H, et al:Preservation of ischemic rat liver mitochondrial functions and liver viability with CoQ10. Surgery 91:631-637, 1982.
PubMed

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