抗菌薬ドリル

出版社： 羊土社
著者：
発行日： 2019-03-10
分野： 臨床医学：内科  >  感染症/AIDS
ISBN： 9784758118446
電子書籍版： 2019-03-10 （第4刷）
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感染症の診断や抗菌薬の選び方・やめ方，アレルギー，感染対策など，感染症診療の基盤になる考え方が問題を解きながら楽しく身につく！やる気をなくすほど難しくはなく，笑い飛ばせるほど簡単じゃない，珠玉の73問に挑戦しよう！

目次

  • 1．これだけは覚える！ 感染症診療に必要な微生物の知識
    2.【抗菌薬の基礎知識(1)】ペニシリン系・セフェム系
    3.【抗菌薬の基礎知識(2)】カルバペネム系・抗MRSA薬
    4.【抗菌薬の基礎知識(3)】その他の重要な抗菌薬（内服抗菌薬を中心に）
    5.【抗菌薬の基礎知識(4)】その他の重要な抗菌薬（嫌気性菌，抗真菌薬）
    6．ペニシリンアレルギー
    7．抗菌薬の要否の判断 ～薬剤耐性（AMR）を防ぐのは僕たちレジデントだっ！～
    8.【診断のためのアプローチ(1)】市中の発熱へのアプローチ：感染症と身体所見
    9.【診断のためのアプローチ(2)】POCT，血液培養，CRPとプロカルシトニン
    10．empiric therapyの考え方
    11．効果判定・経過観察のしかた
    12．培養結果が判明した後の抗菌薬選択，内服薬へ切り替えのタイミング
    13．抗菌薬のやめどき・治療がうまくいかないときのアプローチ
    14．菌血症のマネジメント
    15．研修医に知っておいてほしい感染対策

この書籍の参考文献

参考文献のリンクは、リンク先の都合等により正しく表示されない場合がありますので、あらかじめご了承下さい。

本参考文献は電子書籍掲載内容を元にしております。

序

P.4 掲載の参考文献
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1 これだけは覚える ! 感染症診療に必要な微生物の知識

P.20 掲載の参考文献
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2 [ 抗菌薬の基礎知識 ( 1 ) ] ペニシリン系・セフェム系

P.30 掲載の参考文献
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3 [ 抗菌薬の基礎知識 ( 2 ) ] カルバペネム系・抗MRSA薬

P.41 掲載の参考文献
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4 [ 抗菌薬の基礎知識 ( 3 ) ] その他の重要な抗菌薬 ( 内服抗菌薬を中心に )

P.53 掲載の参考文献
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5 [ 抗菌薬の基礎知識 ( 4 ) ] その他の重要な抗菌薬 ( 嫌気性菌, 抗真菌薬 )

P.65 掲載の参考文献
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6 ペニシリンアレルギー

P.75 掲載の参考文献
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7 抗菌薬の要否の判断～薬剤耐性 ( AMR ) を防ぐのは僕たちレジデントだっ ! ～

P.89 掲載の参考文献
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8 [ 診断のためのアプローチ ( 1 ) ] 市中の発熱へのアプローチ : 感染症と身体所見

P.102 掲載の参考文献
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9 [ 診断のためのアプローチ ( 2 ) ] POCT, 血液培養, CRPとプロカルシトニン

P.112 掲載の参考文献
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4) Diederen BM : Legionella spp. and Legionnaires' disease. J Infect, 56 : 1-12, 2008
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5) Shimada T, et al : Systematic review and metaanalysis : urinary antigen tests for Legionellosis. Chest, 136 : 1576-1585, 2009
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6) Lu X, et al : LAMP-based method for a rapid identification of Legionella spp. and Legionella pneumophila. Appl Microbiol Biotechnol, 92 : 179-187, 2011
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7) Weinstein MP, et al : The clinical significance of positive blood cultures in the 1990s : a prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteremia and fungemia in adults. Clin Infect Dis, 24 : 584-602, 1997
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8) Kassis C, et al : Differentiating culture samples representing coagulase-negative staphylococcal bacteremia from those representing contamination by use of time-to-positivity and quantitative blood culture methods. J Clin Microbiol, 47 : 3255-3260, 2009
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9) Ruiz-Giardin JM, et al : Diagnosis of bacteraemia and growth times. Int J Infect Dis, 41 : 6-10, 2015
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10) 「感染症内科 ただいま診断中! 」 (倉井華子/監修, 伊東直哉/著), 中外医学社, 2017
 
11) 「成人肺炎診療ガイドライン 2017」 (日本呼吸器学会成人肺炎診療ガイドライン2017作成委員会/編), 日本呼吸器学会, 2017
 
12) Povoa P, et al : C-reactive protein as a marker of infection in critically ill patients. Clin Microbiol Infect, 11 : 101-108, 2005
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13) Zhang Z & Ni H : C-reactive protein as a predictor of mortality in critically ill patients : a meta-analysis and systematic review. Anaesth Intensive Care, 39 : 854-861, 2011
 
14) Lobo SM, et al : C-reactive protein levels correlate with mortality and organ failure in critically ill patients. Chest, 123 : 2043-2049, 2003
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15) Ugarte H, et al : Procalcitonin used as a marker of infection in the intensive care unit. Crit Care Med, 27 : 498-504, 1999
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16) Povoa P, et al : Early identification of intensive care unit-acquired infections with daily monitoring of C-reactive protein : a prospective observational study. Crit Care, 10 : R63, 2006
 
17) Simon L, et al : Serum procalcitonin and C-reactive protein levels as markers of bacterial infection : a systematic review and meta-analysis. Clin Infect Dis, 39 : 206-217, 2004
 
18) Davies J : Procalcitonin. J Clin Pathol, 68 : 675-679, 2015
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19) Christ-Crain M & Muller B : Procalcitonin in bacterial infections--hype, hope, more or less? Swiss Med Wkly, 135 : 451-460, 2005
 
20) Fan SL, et al : Diagnosing sepsis-The role of laboratory medicine. Clin Chim Acta, 460 : 203-210, 2016
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10 empiric therapyの考え方

P.124 掲載の参考文献
1) Matsumoto T, et al : Nationwide survey of antibacterial activity against clinical isolates from urinary tract infections in Japan (2008). Int J Antimicrob Agents, 37 : 210-218, 2011
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2) 霧島正浩 : 各都道府県から分離された新鮮臨床分離株125万株の各種抗菌薬に対する感受性検査成績. 診療と新薬, 52 : 23-83, 2015
 
3) Murdoch DR, et al : The NOW S. pneumoniae urinary antigen test positivity rate 6 weeks after pneumonia onset and among patients with COPD. Clin Infect Dis, 37 : 153-154, 2003
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4) Smith LG, et al : Mycoplasma pneumonia and its complications. Infect Dis Clin North Am, 24 : 57-60, 2010
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5) 「Pneumonia Essentials, 3rd ed」 (Cunha BA), pp62-63, Physicians, 2010
 
6) Mermel LA, et al : Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection : 2009 Update by the Infectious Diseases Society of America. Clin Infect Dis, 49 : 1-45, 2009
 
7) Baddour LM, et al : Infective Endocarditis in Adults : Diagnosis, Antimicrobial Therapy, and Management of Complications : A Scientific Statement for Healthcare Professionals From the American Heart Association. Circulation, 132 : 1435-1486, 2015
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8) Fowler VG Jr, et al : Staphylococcus aureus endocarditis : a consequence of medical progress. JAMA, 293 : 3012-3021, 2005
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9) Stevens DL, et al : Practice guidelines for the diagnosis and management of skin and soft tissue infections : 2014 update by the Infectious Diseases Society of America. Clin Infect Dis, 59 : e10-52, 2014
 
10) 「Dermatologic et Venereologic 2nd ed」 (Saurat JH, et al), p109, Editions Masson, 1990
 
11) Janda JM & Abbott SL : The genus Aeromonas : taxonomy, pathogenicity, and infection. Clin Microbiol Rev, 23 : 35-73, 2010
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12) Halow KD, et al : Primary skin infections secondary to Vibrio vulnificus : the role of operative intervention. J Am Coll Surg, 183 : 329-334, 1996
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13) Vinh DC & Embil JM : Rapidly progressive soft tissue infections. Lancet Infect Dis, 5 : 501-513, 2005
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14) 青木洋介 : セフェム系抗菌薬の使い方. 「抗菌薬適正使用生涯教育テキスト 改訂版」 (日本化学療法学会 抗菌化学療法認定医認定制度審議委員会/編), pp63-84, 日本化学療法学会, 2013
 
15) 大曲貴夫 : キノロン系抗菌薬の使い方. 「抗菌薬適正使用生涯教育テキスト 改訂版」 (日本化学療法学会 抗菌化学療法認定医認定制度審議委員会/編), pp85-98, 日本化学療法学会, 2013
 
16) van de Beek D, et al : Community-acquired bacterial meningitis in adults. N Engl J Med, 354 : 44-53, 2006
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17) van de Beek D, et al : Nosocomial bacterial meningitis. N Engl J Med, 362 : 146-154, 2010
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18) Kim KS : Acute bacterial meningitis in infants and children. Lancet Infect Dis, 10 : 32-42, 2010
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19) 「Antibiotic Basics for Clinicians 2nd ed」 (Hauser AR), Lippincott Williams & Wilkins, 2012
 
20) Weinstein MP, et al : Rationale for revised penicillin susceptibility breakpoints versus Streptococcus pneumoniae : coping with antimicrobial susceptibility in an era of resistance. Clin Infect Dis, 48 : 1596-1600, 2009
 
21) Stevens DL, et al : The Eagle effect revisited : efficacy of clindamycin, erythromycin, and penicillin in the treatment of streptococcal myositis. J Infect Dis, 158 : 23-28, 1988
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22) Chen SC, et al : Antibiotic therapy for necrotizing fasciitis caused by Vibrio vulnificus : retrospective analysis of an 8 year period. J Antimicrob Chemother, 67 : 488-493, 2012
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11 効果判定・経過観察のしかた

P.133 掲載の参考文献
1) 「レジデントのための感染症診療マニュアル 第3版」 (青木眞/著), 医学書院, 2015
 
1) 「市中感染症診療の考え方と進め方 第2集」 (IDATENセミナーテキスト編集委員会/編), 医学書院, 2015
 
2) 「抗菌薬おさらい帳」 (関雅文/編著, 石坂敏彦/著), じほう, 2016
 
2) 「ジェネラリストのための内科診断リファレンス」 (酒見英太/監, 上田剛士/著), 医学書院, 2014
 
3) Bruns AH, et al : Patterns of resolution of chest radiograph abnormalities in adults hospitalized with severe community-acquired pneumonia. Clin Infect Dis, 45 : 983-991, 2007
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4) Behr MA, et al : Fever duration in hospitalized acute pyelonephritis patients. Am J Med, 101 : 277-280, 1996
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5) Li JS, et al : Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clin Infect Dis, 30 : 633-638, 2000
 
6) 「日本語版 サンフォード 感染症治療ガイド 2018 第48版」 (Gilbert DN, 他/編, 菊池賢, 橋本正良/日本語版監修), ライフサイエンス出版, 2018
 
7) Jones Hopkins Medicine. Johns Hopkins ABX Guide : https://www.hopkinsguides.com/hopkins/index/Johns_Hopkins_ABX_Guide/All_Topics/A
 
P.134 掲載の参考文献
1) Baddour LM, et al : Infective Endocarditis in Adults : Diagnosis, Antimicrobial Therapy, and Management of Complications : A Scientific Statement for Healthcare Professionals From the American Heart Association. Circulation, 132 : 1435-1486, 2015
PubMed
2) Lowy FD : Methicillin-resistant Staphylococcus aureus (MRSA) in adults : Treatment of bacteremia. UpToDate, 2018
 

12 培養結果が判明した後の抗菌薬選択, 内服薬へ切り替えのタイミング

P.144 掲載の参考文献
1) Clinical and Laboratory Standards Institute : M100-S25 Performance Standards for Antimicrobial Susceptibility Testing ; Twenty-Fifth Informational Supplement. 2015
 
2) 「感染症診療のロジック 患者さんのモンダイを解決するキホンとアプローチ法」 (大曲貴夫/著), 南山堂, 2010
 
3) 「抗菌薬 虎の巻 第2版」 (大曲貴夫/監, 坂野昌志, 他/著), 南山堂, 2016
 
4) 「抗菌薬について内心疑問に思っていること Q&A」 (大曲貴夫/編), 羊土社, 2009
 
5) 「レジデントのための感染症診療マニュアル 第3版」 (青木眞/著), 医学書院, 2015
 
6) 「市中感染症診療の考え方と進め方 第2集」 (IDATENセミナーテキスト編集委員会/編), 医学書院, 2015
 
7) Musher DM, et al : The current spectrum of Staphylococcus aureus infection in a tertiary care hospital. Medicine (Baltimore), 73 : 186-208, 1994
 
8) 早川佳代子, 他 (訳) : 抗菌薬適正使用プログラムの実施 : 米国感染症学会および米国医療疫学学会によるガイドライン. 2016
 
9) 厚生労働省 : 薬剤耐性 (AMR) 対策について. http://www.mhlw.go.jp/stf/seisakunitsuite/bunya/0000120172.html
 
10) AMR臨床リファレンスセンター : http://amr.ncgm.go.jp
 
11) 岩田健太郎 : De-escalationを総括する. J-IDEO, 1 : 5-16, 2017
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12) Paterson DL, et al : Extended-spectrum beta-lactamases : a clinical update. Clin Microbiol Rev, 18 : 657-686, 2005
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13) Doi A, et al : The efficacy of cefmetazole against pyelonephritis caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae. Int J Infect Dis, 17 : e159-e163, 2013
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14) Matsumura Y, et al : Multicenter retrospective study of cefmetazole and flomoxef for treatment of extended-spectrum-β-lactamase-producing Escherichia coli bacteremia. Antimicrob Agents Chemother., 59 : 5107-5113, 2015
 
15) Fukuchi T, et al : Cefmetazole for bacteremia caused by ESBL-producing enterobacteriaceae comparing with carbapenems. BMC Infect Dis, 16 : 427, 2016
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16) Nottingham University Hospitals : Guideline for the intravenous to oral switch of antibiotic therapy. 2010
 

13 抗菌薬のやめどき・治療がうまくいかないときのアプローチ

P.155 掲載の参考文献
1) 「がん診療に携わる人のための 静がん感染症治療戦略」 (伊東直哉, 倉井華子/編著), 日本医事新報社, 2016
 
1) Halm EA, et al : Time to clinical stability in patients hospitalized with community-acquired pneumonia : implications for practice guidelines. JAMA, 279 : 1452-1457, 1998
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2) Bruns AH, et al : Patterns of resolution of chest radiograph abnormalities in adults hospitalized with severe community-acquired pneumonia. Clin Infect Dis, 45 : 983-991, 2007
PubMed
2) 「Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 8th ed」 (Bennett JE, et al, eds), Saunders, 2014
 
3) Mandell LA, et al : Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis, 44 : S27-S72, 2007
 
4) Hayashi Y & Paterson DL : Strategies for reduction in duration of antibiotic use in hospitalized patients. Clin Infect Dis, 52 : 1232-1240, 2011
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5) Hooton TM : Clinical practice. Uncomplicated urinary tract infection. N Engl J Med, 366 : 1028-1037, 2012
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6) Gupta K, et al : International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women : A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis, 52 : e103-e120, 2011
 
7) Kyriakidou KG, et al : Short- versus long-course antibiotic therapy for acute pyelonephritis in adolescents and adults : a meta-analysis of randomized controlled trials. Clin Ther, 30 : 1859-1868, 2008
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8) Stevens DL, et al : Practice guidelines for the diagnosis and management of skin and soft tissue infections : 2014 update by the Infectious Diseases Society of America. Clin Infect Dis, 59 : e10-52, 2014
 
9) Hepburn MJ, et al : Comparison of short-course (5 days) and standard (10 days) treatment for uncomplicated cellulitis. Arch Intern Med, 164 : 1669-1674, 2004
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10) British Lymphology Society & The Lymphoedema Support Network : Consensus Document on the Management of Cellulitis in Lymphoedema. 2016 https://www.lymphoedema.org/images/pdf/CellulitisConsensus.pdf
 
11) Raff AB & Kroshinsky D : Cellulitis : A Review. JAMA, 316 : 325-337, 2016
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12) Alsaawi A, et al : Ultrasonography for the diagnosis of patients with clinically suspected skin and soft tissue infections : a systematic review of the literature. Eur J Emerg Med, 24 : 162-169, 2017
 
13) Eriksson B, et al : Erysipelas : clinical and bacteriologic spectrum and serological aspects. Clin Infect Dis, 23 : 1091-1098, 1996
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14) Johnson DH & Cunha BA : Drug fever. Infect Dis Clin North Am, 10 : 85-91, 1996
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17) Gomi H, et al : Tokyo Guidelines 2018 : antimicrobial therapy for acute cholangitis and cholecystitis. J Hepatobiliary Pancreat Sci, 25 : 3-16, 2018
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18) Mourad O, et al : A comprehensive evidence-based approach to fever of unknown origin. Arch Intern Med, 163 : 545-551, 2003
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14 菌血症のマネジメント

P.163 掲載の参考文献
1) Honda H, et al : The value of infectious diseases consultation in Staphylococcus aureus bacteremia. Am J Med, 123 : 631-637, 2010
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2) Lopez-Cortes LE, et al : Impact of an evidence-based bundle intervention in the quality-of-care management and outcome of Staphylococcus aureus bacteremia. Clin Infect Dis, 57 : 1225-1233, 2013
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3) Mermel LA, et al : Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection : 2009 Update by the Infectious Diseases Society of America. Clin Infect Dis, 49 : 1-45, 2009
 
4) Stryjewski ME, et al : Use of vancomycin or first-generation cephalosporins for the treatment of hemodialysis-dependent patients with methicillin-susceptible Staphylococcus aureus bacteremia. Clin Infect Dis, 44 : 190-196, 2007
 
5) Carr DR, et al : A Comparison of Cefazolin Versus Ceftriaxone for the Treatment of Methicillin-Susceptible Staphylococcus aureus Bacteremia in a Tertiary Care VA Medical Center. Open Forum Infect Dis, 5 : ofy089, 2018
 
6) Spellberg BJ, et al : Current treatment strategies for disseminated candidiasis. Clin Infect Dis, 42 : 244-251, 2006
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7) Takesue Y, et al : Management bundles for candidaemia : the impact of compliance on clinical outcomes. J Antimicrob Chemother, 70 : 587-593, 2015
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8) Pappas PG, et al : Clinical Practice Guideline for the Management of Candidiasis : 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis, 62 : e1-50, 2016
 
9) Crnich CJ & Maki DG : The promise of novel technology for the prevention of intravascular device-related bloodstream infection. II. Long-term devices. Clin Infect Dis, 34 : 1362-1368, 2002
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10) Kuwahara T, et al : Effects of lipid emulsion and multivitamins on the growth of microorganisms in peripheral parenteral nutrition solutions. Int J Med Sci, 10 : 1079-1084, 2013
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11) Kutsuna S, et al : Risk factors of catheter-related bloodstream infection caused by Bacillus cereus : Casecontrol study in 8 teaching hospitals in Japan. Am J Infect Control, 45 : 1281-1283, 2017
 

15 研修医に知っておいてほしい感染対策

P.174 掲載の参考文献
1) KNOW VPD! : http://know-vpd.jp
 
1) 「感染予防, そしてコントロールのマニュアル」 (Damani N/原著, 岩田健太郎/監修, 岡 秀昭/監訳), メディカル・サイエンス・インターナショナル, 2013
 
2) Yip JLY, et al : Outbreaks of influenza-like illness in care homes in the East of England : impact of variations in neuraminidase inhibitor provision. Public Health, 162 : 98-103, 2018
 
2) 「感染対策40の鉄則」 (坂本史衣/著), 医学書院, 2016
 
3) 「Control of Communicable Diseases Manual, 20th Edition」 (Heymann DL, eds), APHA Press, 2014
 
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5) Grohskopf LA, et al : Prevention and Control of Seasonal Influenza with Vaccines : Recommendations of the Advisory Committee on Immunization Practices-United States, 2018-19 Influenza Season. MMWR Recomm Rep, 67 : 1-20, 2018
 
6) Pittet D, et al : Effectiveness of a hospital-wide programme to improve compliance with hand hygiene. Infection Control Programme. Lancet, 356 : 1307-1312, 2000
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7) Public Health Ontario : Best Practices for Hand Hygiene in All Health Care Settings, 4th edition. 2014 https://www.publichealthontario.ca/en/eRepository/2010-12%20BP%20Hand%20Hygiene.pdf
 
8) Sax H, et al : 'My five moments for hand hygiene' : a user-centred design approach to understand, train, monitor and report hand hygiene. J Hosp Infect, 67 : 9-21, 2007
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9) World Health Organization : WHO Guidelines on Hand Hygiene in Health Care. 2009 http://www.who.int/gpsc/5may/tools/9789241597906/en/
 
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11) Sepkowitz KA : Health Care-Acquired Hepatitis.「Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 8th Edition」 (Bennett J, et al), Saunders, 2014
 
12) Tokars JI, et al : Surveillance of HIV infection and zidovudine use among health care workers after occupational exposure to HIV-infected blood. The CDC Cooperative Needlestick Surveillance Group. Ann Intern Med, 118 : 913-919, 1993
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13) Centers for Disease Control and Prevention (CDC). : CDC guidance for evaluating health-care personnel for hepatitis B virus protection and for administering postexposure management. MMWR Recomm Rep, 62 : 1-19, 2013
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14) Panlilio AL, et al : Updated U. S. Public Health Service guidelines for the management of occupational exposures to HIV and recommendations for postexposure prophylaxis. MMWR Recomm Rep, 54 : 1-17, 2005
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15) US Public Health Service Working Group : Updated US Public Health Service guidelines for the management of occupational exposures to human immunodeficiency virus and recommendations for postexposure prophylaxis. Infect Control Hosp Epidemiol, 34 : 875-892, 2013
 
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18) 地方公務員災害補償基金 : 病院等における災害防止対策研修ハンドブック 針刺し切創防止版. 2010 http://www.chikousai.jp/gyoumu/bousi/pdf/bousi32.pdf
 
19) Centers for Disease Control and Prevention : 2007 Guideline for Isolation Precautions : Preventing Transmission of Infectious Agents in Healthcare Settings. 2007 https://www.cdc.gov/infectioncontrol/pdf/guidelines/isolation-guidelines-H.pdf
 
20) 国立感染症研究所 : 中東呼吸器症候群 (MERS) ・鳥インフルエンザ (H7N9) に対する院内感染対策. 2014 https://www.niid.go.jp/niid/ja/diseases/alphabet/mers/2186-idsc/4853-mers-h7-hi.html
 
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22) Society for Healthcare Epidemiology of America : SHEA guideline for management of healthcare workers who are infected with hepatitis B virus, hepatitis C virus, and/or human immunodeficiency virus. Infect Control Hosp Epidemiol, 31 : 203-232, 2010
 

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