Ortho Supportの　整形外科手術部位感染対策

出版社： 文光堂
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発行日： 2022-05-02
分野： 臨床医学：外科  >  整形外科学
ISBN： 9784830627729
電子書籍版： 2022-05-02 （第1版第1刷）
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院内感染の中で最も多い感染症である手術部位感染（SSI）は，整形外科領域でその数が最も多く，予期せぬ再入院の原因，さらには下肢切断・生死に関わる問題となることもある．本書では国内外の多くのガイドライン作成に携わり，同時に豊富な臨床実践を持つ著者が，具体的で時に一歩踏み込んだ内容なども含め，SSI対策のノウハウを解説している．巻末の「SSI予防のための最新テクノロジー」では具体的な商品・注意点を紹介するなど，日常臨床にすぐに役立つ内容が満載の1冊となっている．

目次

  • 1　手術部位感染（SSI）とは
    2　術後発熱患者の診断
    3　検体採取のコツ
    4　整形外科でのSSIリスク
    5　術前のSSI対策
    6　術中のSSI対策−予防抗菌薬−
    7　術中のSSI対策−その他−
    8　術後のSSI対策
    9　MSIS 2018のSSI対策
    10　ケアバンドルの考え方
    11　普段から行うべきSSIへの取り組み
    12　整形外科SSI研究を行う上での注意点

    付録1　整形外科医として知っておきたいSSI予防ガイドライン
    付録2　各種ガイドラインの推奨グレードとエビデンスレベル，CDCの創分類

    SSI予防のための最新テクノロジー

この書籍の参考文献

参考文献のリンクは、リンク先の都合等により正しく表示されない場合がありますので、あらかじめご了承下さい。

本参考文献は電子書籍掲載内容を元にしております。

I 手術部位感染 ( SSI ) とは

P.12 掲載の参考文献
1) Petherick ES, et al : Methods for identifying surgical wound infection after discharge from hospital : a systematic review. BMC Infect Dis 6 : 170, 2006
 
2) Mangram AJ, et al : Guidelin for prevention of surgical site infection, 1999. Hospital Infection Control Practices Advisory Committee. Infect Control Hosp Epidemiol 20 : 250-278, 1999
 
3) National Healthcare Safety Network. Centers for Disease Control and Prevention. Surgical site infection (SSI) event. http://www.cdc.gov/nhsn/pdfs/pscmanual/9pscssicurrent.pdf, 2017 (2017年7月25日閲覧)
 
4) Chiew YF, et al : Comparison of infection rate using different methods of assessment for surveillance of total hip replacement surgical site infections. ANZ J Surg 77 : 535-539, 2007
PubMed
5) Sorensen TS, et al : Orthopedic wound infections. 182 cases after 8913 operations during an 8-year survey. Acta Orthop Scand 68 : 466-469, 1997
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6) Allami MK, et al : Superficial incisional infection in arthroplasty of the lower limb. Interobserver reliability of the current diagnostic criteria. J Bone Joint Surg Br 87 : 1267-1271, 2005
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7) Huotari K, et al : Validation of surgical site infection surveillance in orthopedic procedures. Am J Infect Control 35 : 216-221, 2007
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8) Proceedings of the International Consensus Meeting on Periprosthetic Joint Infection, 2013. http://www.msis-na.org/wp-content/themes/msistemp/pdf/ism-periprosthetic-jointinformation.pdf (2017年12月1日閲覧)
 
9) 整形外科手術サーベイランスにおけるSSIの定義は. 骨・関節術後感染予防ガイドライン 2015, 改訂第2版. 日本整形外科学会診療ガイドライン委員会, 骨・関節術後感染予防ガイドライン策定委員会編. 南江堂, 東京, 12-17, 2015
 
10) Zimlichman E, et al. Health care-associated infections : a meta-analysis of costs and financial impact on the US health care system. JAMA Intern Med 173 : 2039-46, 2013
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11) Sievert DM, et al : Antimicrobial-resistant pathogens associated with healthcare-associated infections summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009-2010. Infect Control Hosp Epidemiol 4 : 1-14, 2013
 
12) Merkow RP, et al : Underlying reasons associated with hospital readmission following surgery in the United States. JAMA 313 : 483-495, 2015
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13) Bernatz JT, et al : What are the 30-day readmission rates across orthopaedic subspecialties?. Clin Orthop Relat Res 474 : 838-847, 2016
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14) Shimizu T, et al : A multi-center study of reoperations within 30 days of spine surgery. Eur Spine J 25 : 828-835, 2016
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15) Nohar Y, et al : Nationwide survey on complications of spine surgery in Japan. J Orthop Sci 9 : 424-433, 2004
 
16) Petilon JM, et al : Clinical outcomes after lumbar fusion complicated by deep wound infection : a case-control study. Spine 372 : 1370-1374, 2012
 
17) Nunez-Pereira S, et al : Implant survival after deep infection of an instrumented spinal fusion. Bone Joint J 95 : 1121-1126, 2013
PubMed
18) Leung F, et al : Two-stage total hip arthroplasty : how often does it control methicillin-resistant infection? Clin Orthop Relat Res 469 : 1009-1015, 2011
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19) Toulson C, et al : Treatment of infected total hip arthroplasty with a 2-stage reimplantation protocol : update on "our institution's" experience from 1989 to 2003. J Arthroplasty 24 : 1051-1060, 2009
 
20) Berrios-Torres SI, et al : Centers for Disease Control and Prevention guideline for the prevention of surgical site infection, 2017. JAMA Surg 152 : 784-791, 2017
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24) The European Centre for Disease Prevention and Control (ECDC) : Antimicrobial resistance surveillance in Europe 2013. https://www.ecdc.europa.eu/sites/default/files/media/en/publications/Publications/antimicrobial-resistancesurveillance-europe-2013.pdf. (閲覧日2018年12月1日)
 
25) Public Health England : Surveillance of surgical site infections in NHS hospitals in England 2015/16. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/577418/Surgical_site_infections_NHS_hospitals_2015_to_2016.pdf. (閲覧日2018年12月1日)
 

II 術後発熱患者の診断

P.31 掲載の参考文献
1) 中嶋香児ほか : 清潔整形外科手術で手術部位感染の臨床所見は感染の深達度で異なるか? 日本骨・関節感染症学会プログラム・抄録集 39 : 93-93, 2016
 
2) Musculoskeletal Infection Society : Second International Consensus Meeting (ICM) on musculoskeletal infection, 2018. https://icmphilly.com/document. (閲覧日2021年5月9日)
 
3) Peersman G, et al : Infection in total knee replacement : a retrospective review of 6489 total knee replacements. Clin Orthop Relat Res 392 : 15-23, 2001
PubMed
4) Public Health England : Surveillance of surgical site infections in NHS hospitals in England 2013/14. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/386927/SSI_report_2013_14_final_3_.pdf. (閲覧日2021年9月23日)
 
5) VIII章 骨髄炎・関節炎. JAID/JSC感染症治療ガイド 2019. JAID/JSC感染症治療ガイド・ガイドライン作成委員会編. 日本感染症学会・日本化学療法学会, 東京, 160-177, 2019
 

III 検体採取のコツ

P.39 掲載の参考文献
1) Bourouiba L : Turbulent gas clouds and respiratory pathogen emissions : Potential implications for reducing transmission of COVID-19. JAMA 323 : 1837-1838, 2020
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2) Weinstein MP, et al : The clinical significance of positive blood cultures in the 1990 s : a prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteremia and fungemia in adults. Clin Infect Dis 24 : 584-602, 1997
 

IV 整形外科でのSSIリスク

P.66 掲載の参考文献
1) Musculoskeletal Infection Society : Second International Consensus Meeting (ICM) on Musculoskeletal Infection, 2018. https://icmphilly.com/document/ (2021年9月23日閲覧)
 
2) Mark JD, et al : Incidence of infective endocarditis in England, 2000-13 : a secular trend, interrupted time-series analysis. Lancet 385 : 1219-1228, 2015
 
3) Resende VAC, et al : Higher age, female gender, osteoarthritis and blood transfusion protect against periprosthetic joint infection in total hip or knee arthroplasties : a systematic review and meta-analysis. Knee Surg Sports Traumatol Arthrosc 29 : 8-43, 2021
 
4) Zhu Y, et al : Risk factors for periprosthetic joint infection after total joint arthroplasty : a systematic review and meta-analysis. J Hosp Infect 89 : 82-89, 2015
PubMed
5) Kunutsor SK, et al : Re-infection outcomes following one- and two-stage surgical revision of infected knee prosthesis : A systematic review and meta-analysis. PLoS One 11 : e0151537, 2016
PubMed
6) Shohat N, et al : Inadequate glycemic control is associated with increased surgical site infection in total arthroplasty : A systemic review and meta-analysis. J Arthroplasty 33 : 2312-2321, 2018
 
7) Jiranek W, et al : General assembly, prevention, host risk mitigation-general factors : Proceedings of international consensus on orthopedic infections. J Arthroplasty 34 : S43-S48, 2019
PubMed
8) Momohara S, et al : Prosthetic joint infection after total hip or knee arthroplasty in rheumatoid arthritis patients treated with nonbiologic and biologic disease-modifying antirheumatic drugs. Mod Rheumatol 21 : 469-475, 2011
PubMed
9) Cordtz RL, et al : Predictors of revision, prosthetic joint infection and mortality following total hip or total knee arthroplasty in patients with rheumatoid arthritis : a nationwide cohort study using Danish healthcare registers. Ann Rheum Dis 77 : 281-288, 2018
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10) 日本リウマチ学会 : 関節リウマチ (RA)に対するTNF阻害薬使用ガイドライン (2018年11月4日改訂版), 2018
 
11) Zainul-Abidin S, et al : General assembly, prevention, host related general : Proceedings of international consensus on orthopedic infections. J Arthroplasty 34 : S13-S35, 2019
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12) Aalirezaie A, et al : General assembly, prevention, host risk mitigation-local factors : Proceedings of international consensus on orthopedic infections. J Arthroplasty 34 : S37-S41, 2019
PubMed
13) Ge DH, et al : Preoperative diagnosis can predict conversion total knee arthroplasty outcomes. J Arthroplasty 33 : 124-129. e1, 2018
 
14) Bozic KJ, et al : Risk factors for early revision after primary total hip arthroplasty in Medicare patients. Clin Orthop Relat Res 472 : 449-454, 2014
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15) Pulido L, et al : Periprosthetic joint infection : the incidence, timing, and predisposing factors. Clin Orthop Relat Res 466 : 1710-1715, 2008
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16) Ares O, et al : General assembly section, prevention, host related local : Proceedings of international consensus on orthopedic infections. J Arthroplasty 34 : S3-S12, 2019
 
17) Jaberi FM, et al : Procrastination of wound drainage and malnutrition affect the outcome of joint arthroplasty. Clin Orthop Relat Res 466 : 1368-1371, 2008
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18) Cavanaugh PK, et al : Complications and mortality in chronic renal failure patients undergoing total joint arthroplasty : A comparison between dialysis and renal transplant patients. J Arthroplasty 31 : 465-472, 2016
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19) Kuo SJ, et al : Hepatitis B virus infection is a risk factor for periprosthetic joint infection among males after total knee arthroplasty : A Taiwanese nationwide population-based study. Medicine (Baltimore) 95 : e3806, 2016
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20) Jiang SL, et al : Increased rates of periprosthetic joint infection in patients with cirrhosis undergoing total joint arthroplasty. Clin Orthop Relat Res 472 : 2483-2491, 2014
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21) Devin CJ, et al : Intrawound vancomycin decreases the risk of surgical site infection after posterior spine surgery : A multicenter analysis. Spine (Phila Pa 1976) 43 : 65-71, 2017
 
22) Kang KT, et al : Variation of C-reactive protein and white blood cell counts in spinal operation : Primary fusion surgery versus revision fusion surgery. Korean J Spine 14 : 66-70, 2017
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23) Picada R, et al : Postoperative deep wound infection in adults after posterior lumbosacral spine fusion with instrumentation : incidence and management. J Spinal Disord 13 : 42-45, 2000
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24) Smith JS, et al : Rates of infection after spine surgery based on 108,419 procedures : a report from the Scoliosis Research Society Morbidity and Mortality Committee. Spine (Phila Pa 1976) 36 : 556-563, 2011
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25) Weinstein MA, et al : Postoperative spinal wound infection : a review of 2,391 consecutive index procedures. J Spinal Disord 13 : 422-426, 2000
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26) Yamada K, et al : Evidence-based care bundles for preventing surgical site infections in spinal instrumentation surgery. Spine (Phila Pa 1976) 43 : 1765-1773, 2018
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27) Schwab F, et al : Adult spinal deformity-postoperative standing imbalance : how much can you tolerate? An overview of key parameters in assessing alignment and planning corrective surgery. Spine (Phila Pa 1976) 35 : 2224-2231, 2010
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28) Sing DC, et al : Increase in spinal deformity surgery in patients age 60 and older is not associated with increased complications. Spine J 17 : 627-635, 2017
 
29) Nunez-Pereira S, et al : Implant survival after deep infection of an instrumented spinal fusion. Bone Joint J 95-B : 1121-1126, 2013
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30) Pesenti S, et al ; Scoliosis Research Society (SRS) : What are the risk factors for surgical site infection after spinal fusion? A meta-analysis. Eur Spine J 27 : 2469-2480, 2018
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31) Tominaga H, et al : Risk factors for surgical site infection and urinary tract infection after spine surgery. Eur Spine J 25 : 3908-3915, 2016
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32) Liu JM, et al : Risk factors for surgical site infection after posterior lumbar spinal surgery. Spine (Phila Pa 1976) 43 : 732-737, 2018
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33) Schuster JM, et al : The influence of perioperative risk factors and therapeutic interventions on infection rates after spine surgery. A systematic review. Spine (Phila Pa 1976) 35 : S125-S137, 2010
PubMed
34) Glassman S, et al : Predictors of hospital readmission and surgical site infection in the United States, Denmark, and Japan. Spine (Phila Pa 1976) 42 : 1311-1315, 2010
 
35) Pull ter Gunne AF, et al : A methodological systematic review on surgical site infections following spinal surgery : part 1 : risk factors. Spine (Phila Pa 1976) 37 : 2017-2033, 2012
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36) Fei Q, et al : Risk factors for surgical site infection after spinal surgery : A meta-analysis. World Neurosurg 95 : 507-515, 2016
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37) Durand WM, et al : Tobacco use and complications following spinal fusion : A comparison of the NSQIP and NIS datasets. World Neurosurg 123 : e393-e407, 2019
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47) Noailles T, et al : What are the risk factors for post-operative infection after hip hemiarthroplasty? Systematic review of literature. Int Orthop 40 : 1843-1848, 2016
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48) de Jong L, et al : Factors affecting the rate of surgical site infection in patients after hemiarthroplasty of the hip following a fracture of the neck of the femur. Bone Joint J 99-B : 1088-94, 2017
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49) Zajonz D, et al : Risk factors for early infection following hemiarthroplasty in elderly patients with a femoral neck fracture. Eur J Trauma Emerg Surg 45 : 207-212, 2019
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50) Cordero J, et al : Surgical delay as a risk factor for wound infection after a hip fracture. Injury 47 : S56-S60, 2016
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51) Pereira HO, et al : Length of preoperative hospital stay : a risk factor for reducing surgical infection in femoral fracture cases. Rev Bras Ortop 50 : 638-646, 2015
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53) Olsen LL, et al : The impact of lifestyle risk factors on the rate of infection after surgery for a fracture of the ankle. Bone Joint J 99-B : 225-230, 2017
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54) Sun Y, et al : Incidence and risk factors for surgical site infection after open reduction and internal fixation of ankle fracture : A retrospective multicenter study. Medicine (Baltimore) 97 : e9901, 2018
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55) Shao J, et al : Risk factors for surgical site infection following operative treatment of ankle fractures : A systematic review and meta-analysis. Int J Surg 56 : 124-132, 2018
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56) Ren T, et al : Risk factors for surgical site infection of pilon fractures. Clinics (Sao Paulo) 70 : 419-422, 2015
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57) Liang Y, et al : Analyzing risk factors for surgical site infection following Pilon fracture surgery. Zhongguo Gu Shang 27 : 650-653, 2014
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58) Shao J, et al : Incidence and risk factors for surgical site infection after open reduction and internal fixation of tibial plateau fracture : A systematic review and meta-analysis. Int J Surg 41 : 176-182, 2017
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V 術前のSSI対策

P.89 掲載の参考文献
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3) Shao J, et al : Incidence and risk factors for surgical site infection after open reduction and internal fixation of tibial plateau fracture : A systematic review and meta-analysis. Int J Surg 41 : 176-182, 2017
PubMed
4) Pesenti S, et al ; Scoliosis Research Society (SRS) : What are the risk factors for surgical site infection after spinal fusion? A meta-analysis. Eur Spine J 27 : 2469-2480, 2018
PubMed
5) Pull ter Gunne AF, et al : A methodological systematic review on surgical site infections following spinal surgery : part 1 : risk factors. Spine (Phila Pa 1976) 37 : 2017-2033, 2012
PubMed
6) Durand WM, et al : Tobacco Use and Complications Following Spinal Fusion : A Comparison of the NSQIP and NIS Datasets. World Neurosurg 123 : e393-e407, 2019
PubMed
7) Resende VAC, et al : Higher age, female gender, osteoarthritis and blood transfusion protect against periprosthetic joint infection in total hip or knee arthroplasties : a systematic review and meta-analysis. Knee Surg Sports Traumatol Arthrosc 29 : 8-43, 2021
 
8) Kunutsor SK, et al : Re-infection outcomes following one- and two-stage surgical revision of infected knee prosthesis : A systematic review and meta-analysis. PLoS One 11 : e0151537, 2016
PubMed
9) Zainul-Abidin S, et al : General assembly, prevention, host related general : Proceedings of international consensus on orthopedic infections. J Arthroplasty 34 : S13-S35, 2019
PubMed
10) Moller AM, et al : Effect of preoperative smoking intervention on postoperative complications : a randomised clinical trial. Lancet 359 : 114-117, 2002
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13) Zhu Y, et al : Risk factors for periprosthetic joint infection after total joint arthroplasty : a systematic review and meta-analysis. J Hosp Infect 89 : 82-89, 2015
PubMed
14) Shohat N, et al : Inadequate glycemic control is associated with increased surgical site infection in total arthroplasty : A systemic review and meta-analysis. J Arthroplasty 33 : 2312-2321, 2018
 
15) Jiranek W, et al : General Assembly, Prevention, Host Risk Mitigation-General Factors : Proceedings of International Consensus on Orthopedic Infections. J Arthroplasty 34 : S43-S48, 2019
PubMed
16) Liu JM, et al : Risk factors for surgical site infection after posterior lumbar spinal surgery. Spine (Phila Pa 1976) 43 : 732-737, 2018
PubMed
17) Schuster JM, et al : The influence of perioperative risk factors and therapeutic interventions on infection rates after spine surgery. A systematic review. Spine (Phila Pa 1976) 35 : S125-S137, 2010
PubMed
18) Glassman S, et al : Predictors of hospital readmission and surgical site infection in the United States, Denmark, and Japan. Spine (Phila Pa 1976) 42 : 1311-1315, 2010
 
19) Bachoura A, et al : Infirmity and injury complexity are risk factors for surgical-site infection after operative fracture care. Clin Orthop Relat Res 469 : 2621-2630, 2011
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20) OECD Health Statisties 2015. http://dx.doi.org/co.1787/health-data-en. (2016年4月30日閲覧)
 
21) Fei Q, et al : Risk factors for surgical site infection after spinal surgery : A meta-analysis. World Neurosurg 95 : 507-515, 2016
PubMed
22) Noailles T, et al : What are the risk factors for post-operative infection after hip hemiarthroplasty? Systematic review of literature. Int Orthop 40 : 1843-1848, 2016
PubMed
23) Zajonz D, et al : Risk factors for early infection following hemiarthroplasty in elderly patients with a femoral neck fracture. Eur J Trauma Emerg Surg 45 : 207-212, 2019
PubMed
24) Olsen LL, et al : The impact of lifestyle risk factors on the rate of infection after surgery for a fracture of the ankle. Bone Joint J 99-B : 225-230, 2017
PubMed
25) Sun Y, et al : Incidence and risk factors for surgical site infection after open reduction and internal fixation of ankle fracture : A retrospective multicenter study. Medicine (Baltimore) 97 : e9901, 2018
PubMed
26) Shao J, et al : Risk factors for surgical site infection following operative treatment of ankle fractures : A systematic review and meta-analysis. Int J Surg 56 : 124-132, 2018
PubMed
27) Dayer MJ, et al : Incidence of infective endocarditis in England, 2000-13 : a secular trend, interrupted time-series analysis. Lancet 385 : 1219-1228, 2015
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37) Chen AF, et al : Staphylococcus aureus screening and decolonization in orthopaedic surgery and reduction of surgical site infections. Clin Orthop Relat Res 471 : 2383-2399, 2013
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39) Skramm I, et al : Surgical site infections in orthopaedic surgery demonstrate clones similar to those in orthopaedic Staphylococcus aureus nasal carriers. J Bone Joint Surg Am 96 : 882-888, 2014
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VI 術中のSSI対策 - 予防抗菌薬 -

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VII 術中のSSI対策 - その他 -

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VIII 術後のSSI対策

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IX MSIS 2018のSSI予防

P.231 掲載の参考文献
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X ケアバンドルの考え方

P.235 掲載の参考文献
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XI 普段から行うべきSSIへの取り組み

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XII 整形外科SSI研究を行う上での注意点

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[ 付録1 ] 整形外科医として知っておきたいSSI予防ガイドライン

P.265 掲載の参考文献
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[ 付録2 ] 各種ガイドラインの推奨グレードとエビデンスレベル, CDCの創分類

P.268 掲載の参考文献
1) 日本化学療法学会/日本外科感染症学会術後感染予防抗菌薬適正使用に関するガイドライン作成委員会 : 術後感染予防抗菌薬適正使用のための実践ガイドライン. 日化療会誌 64 : 153-232, 2016. http://www.chemotherapy.or.jp/guideline/jyutsugo_shiyou_jissen.pdf
 
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SSI予防のための最新テクノロジー

P.271 掲載の参考文献
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