プロトンポンプ阻害薬ハンドブック

出版社： 先端医学社
著者：
発行日： 2006-09-20
分野： 臨床医学：一般  >  薬物療法
ISBN： 488407288X
電子書籍版： 2006-09-20 （第1版第1刷）
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日常診療でも頻繁に遭遇する胃・十二指腸潰瘍などの酸関連疾患は、近年、内科的療法によっても容易に治癒しうる疾患となった。本書は、プロトンポンプ阻害薬（PPI）の薬理学的 特徴はもとより、適応疾患に対する処方の実際、NSAIDs潰瘍をはじめとした今後適応の拡大が予想される疾患に対する考え方や治療成績など、実地診療に即した情報が網羅され、患者とともに最適な治療を決定するうえで大いに参考となる一冊。

目次

  • プロトンポンプ阻害薬ハンドブック

    ―目次―

    PART.1　プロトンポンプ阻害薬の開発の歴史をみる

    PART.2　消化性潰瘍治療におけるプロトンポンプ阻害薬の
    　　　　　インパクトを探る

    PART.3　21世紀におけるプロトンポンプ阻害薬の臨床的意義を探る
    　1．Helicobacter pylori 除菌時代における
    　　　プロトンポンプ阻害薬の意義を探る
    　2．EBM からみたプロトンポンプ阻害薬の臨床的意義を探る
    　3．医療経済からみたプロトンポンプ阻害薬の有用性をみる
    　4．オーダーメイド医療から考えるプロトンポンプ阻害薬の
    　　　役割を探る

    PART.4　薬理学からみたプロトンポンプ阻害薬の特徴をみる
    　1．プロトンポンプ阻害薬の酸分泌抑制効果にみる
    　　　酸分泌コントロールの意義を探る
    　　 　―ヒスタミン H2受容体拮抗薬との相違を含めて―
    　2．プロトンポンプ阻害薬の胃粘膜に対する影響と
    　　　胃粘膜保護作用をみる
    　3．プロトンポンプ阻害薬のHelicobacter pylori の
    　　　静菌効果と臨床的意義を探る
    　4．プロトンポンプ阻害薬の薬物動態からみた臨床的特徴をみる

    PART.5　プロトンポンプ阻害薬を用いた臨床応用の実際をみる
    　　　 　　―投与量、投与期間などを含め―
    　1．酸関連疾患における酸分泌抑制の意義を探る
    　2．胃潰瘍におけるプロトンポンプ阻害薬の適応と
    　　　処方の実際をみる
    　3．十二指腸潰瘍におけるプロトンポンプ阻害薬の
    　　　適応と処方の実際をみる
    　4．非ステロイド性抗炎症薬潰瘍における
    　　　プロトンポンプ阻害薬の適応と処方の実際をみる
    　5．急性胃炎・急性胃粘膜病変におけるプロトンポンプ阻害薬の
    　　　適応と処方の実際をみる
    　6．上部消化管出血におけるプロトンポンプ阻害薬の
    　　　適応と処方の実際をみる
    　7．ゾリンジャー−エリソン症候群における
    　　　プロトンポンプ阻害薬の適応と処方の実際をみる
    　8．消化器外科の治療におけるプロトンポンプ阻害薬の
    　　　役割と実際をみる　
    　
    PART.6　胃食道逆流症治療におけるプロトンポンプ阻害薬の
    　　　　　臨床的意義を探る
    　1．胃食道逆流症治療の目的と患者 QOL に果たす役割を考察する
    　2．胃食道逆流症の病態における酸分泌抑制の意義と
    　　　プロトンポンプ阻害薬の適応をみる
    　3．実地診療でおこなう胃食道逆流症治療と
    　　　プロトンポンプ阻害薬による臨床応用をみる
    　4．胃食道逆流症治療の経過観察とプロトンポンプ阻害薬の
    　　　効果判定基準を考察する

    PART.7　Helicobacter pylori 除菌治療における
    　　　　プロトンポンプ阻害薬の臨床的意義を探る
    　1．Helicobacter pylori 除菌治療の補助薬としての
    　　　プロトンポンプ阻害薬の意義を探る
    　2．ガイドラインからみたHelicobacter pylori 除菌治療をみる
    　3．包括的医療からみたHelicobacter pylori 除菌治療の
    　　　意義を考察する
    　4．Helicobacter pylori 除菌時のインフォームド・コンセントの
    　　　進め方とそのポイントをみる
    　5．Helicobacter pylori 除菌後の維持療法の必要性と
    　　　プロトンポンプ阻害薬の適応をみる
    　6．Helicobacter pylori 除菌不成功例における
    　　　プロトンポンプ阻害薬の適応と二次除菌療法の有用性をみる
    　7．プロトンポンプ阻害薬がHelicobacter pylori 診断に
    　　　与える影響をみる

    PART.8　プロトンポンプ阻害薬の使い方と注意点
    　1．プロトンポンプ阻害薬の処方上の注意点と課題を検証する
    　2．プロトンポンプ阻害薬の有害事象と薬物間相互作用の対応をみる
    　3．患者満足度からみたプロトンポンプ阻害薬による治療を考察する

この書籍の参考文献

参考文献のリンクは、リンク先の都合等により正しく表示されない場合がありますので、あらかじめご了承下さい。

本参考文献は電子書籍掲載内容を元にしております。

PART1. プロトンポンプ阻害薬の開発の歴史をみる

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PART2. 消化性潰瘍治療におけるプロトンポンプ阻害薬のインパクトを探る

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PART3. 21世紀におけるプロトンポンプ阻害薬の臨床的意義を探る

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PART4. 薬理学からみたプロトンポンプ阻害薬の特徴をみる

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5) 大蔵隆一, 佐藤信紘:プロトンポンプ阻害薬の抗菌作用と臨床的有用性. プロトンポンプ阻害薬のすべて, 浅香正博, 千葉勉編, 先端医学社, 東京, 2002, pp.79-82
 
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12) Hamlet A, Stage L, Lonroth H et al:Anovel tablet-based 13C-urea breath test for Helicobacter pylori with enhanced performance during acid suppression therapy Scand J Gastroenterol 34:367-374, 1999
 
13) Savarino V, Bisso G, Pivari M et al:Effect of gestric acid suppression on 13C-urea breath test:comparison of ranitidine with omeprazole. Aliment Pharma Ther 14:291-297, 2000
 
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20) Fbuad YM, Katz PO, Castell DO:Oesophageal motility defects associated with nocturnal gastro-oesophageal reflux on proton pump inhibitors. Aliment Pharmacol Ther 13:1467-1471, 1999
 

PART5. プロトンポンプ阻害薬を用いた臨床応用の実際をみる 投与量,投与期間などを含め

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18) Eissele R, Brunner G, Simon B et al:Gastric mucosa during treatment with lansoprazole:Helicobacter pylori is a risk factor for argyrophil cell hyperplasia [comment] [see comments]. Gastroenterology 112:707-717, 1997
 
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20) Lundell L, Miettinen P, Myrvold HE et al:Lack of effect of acid suppression therapy on gastric atrophy. Nordic Gerd Study Group. Gastroenterology 117:319-326, 1999
 
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3) van der Hulst RW Rauws EA, Koycu B et al:Prevention of ulcer reccurrence after eradication of Helicobacter pylori:aprospective long-term follow-up study Gastroenterol 113:1082-1086, 1997
 
4) Miwa H, Sakaki N, Sugano K et al:Recurrent peptic ulcers in patients following successful Helicobacter pylori eradication:Amulticenter study of 4940 patients. Helicobacter 9:9-16, 2004
 
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9) Hawkey CJ, Karrasch JA, Szczepanski L et al:Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. 2V Engl J Med 338:727-734, 1998
 
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PART6. 胃食道逆流症治療におけるプロトンポンプ阻害薬の臨床的意義を探る

P.168 掲載の参考文献
1) GERD ガイドラインワークショップレポート 2002, GERD研究会発行, 2002
 
2) 0kamoto K, Iwakiri R, Mori M et al:Clinical symptoms in endoscopic reflux esophagitis:evaluation in 8031 adult subjects. Dig Dis Sci 48:2237-2241, 2003
 
3) 大原秀一, 神津照雄, 河野辰幸ほか:全国調査における日本人の胸やけ・逆流性食道炎に関する疫学的検討. 日消誌 102:1010-1024, 2005
 
4) Dimenas E:Methodological aspect of evaluation of quality of life in upper gastrointestinal diseases. Scand J Gastroenterol 28 (suppl 199):s18-s21, 1993
 
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8) Carlsson R, Dent J, Bolling-Sternvald E et al:The usefulness of a structured questionnaire in the assessment of symptomatic gastroesophageal reflux disease. Scand J Gastroenterol 33:1023-1029, 1998
 
9) 永野公一, 久保光彦, 近藤守孝ほか:GERD の診断に関する研究. 新薬と臨 47:841-851, 1998
 
10) Velanovich V, Vallance SR, Gusz JR et al:Quality of life scale for gastroesophageal reflux disease. J Am Coll Surg 183:217-224, 1996
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11) Kusano M, Shimoyama Y, Sugimoto S et al:Development and evaluation of FSSG:frequency scale for symptoms of GERD. J Gastoroenterol 39:888-891, 2004
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12) DeVaault KR, Castell DO:Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. Am J Gastroeterol 100:190-200, 2005
 
13) Havelund T, Lind T, Wiklund I, Glise H et al:Quality of life in patients with heartburn but without esophagitis:effects of treatment with Omeprazole. Am J Gastroeterol 94:1723-1724, 1999
 
14) Revicki DA, Sorenson S, Maton PN et al:Health related quality of life outcomes ofomeprazole versus ranitidine in poorly responsive symptomatic gastroesophageal reflux disease. Dig Dis 16:284-291, 1998
 
15) Lauritsen K:Management of Endoscopy-negative reflux disease:progress with short-term treatment. Aliment Pharmacol Ther 11 (suppl 2):s87-s92, 1997
 
16) Johanson JE Siddique R, Damiano AM et al:Rabeprazole improves health-related quality of life in patients with erosive gastroesophageal reflux disease. Dig Dis Sci 47:2574-2578, 2002
 
17) 0da K, Iwakiri l, Hara M et al:Dysphagia associated with gastroesophageal reflux disease is improved by proton pump inhibitor. Dig Dis Sci 50:1921-1926, 2005
 
P.178 掲載の参考文献
1) Komazawa Y, Adachi K, Mihara T et al:Tolerance to famotidine and ranitidine treatment after 14 days of administration in healthy subjects without Helicobacter pylori infection. J Gastroenterol Hepatol 18:678-682, 2003
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2) Fujisawa T, Adachi K, Komazawa Y et al:Helicobacter pylori infection prevents the occurrence of the tolerance phenomenon of histamine H2 receptor antagonists. Aliment Pharmacol Ther 20:559-565, 2004
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3) Katsube T, Adachi K, Kawamura A et al:Helicobacter pylori infection influences nocturnal gastric acid breakthrough. Aliment Pharmacol Ther 14:1049-1056, 2000
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4) Vakil N:Review article:new pharmacological agents for the treatment of gastro-oesophageal refiux disease. Aliment Pharmacol Ther 19:1041-1049, 2004
 
5) Adachi K, Fujishiro H, Katsube T et al:Predominant nocturnal acid reflux in patients with Los Angeles grade C and D reflux esophagitis. J Gastroenterol Hepatol 16:1191-1196, 2001
 
6) Fujishiro H, Adachi K, Kawamura A et al:Influence of Helicobacter pylori infection on the prevalence of reflux esophagitis in Japanese patients. J Gastroenterol. Hepatol 16:1217-1221, 2001
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7) Adachi K, Komazawa Y, Fujishiro H etal:Nocturnal gastric acid breakthrough during the administration of rabeprazole and ranitidine in Helicobacter pylori-negative subjects:effects of different regimens. J Gastroenterol 38:830-835, 2003
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8) Adachi K, Komazawa Y, Mihara T et al:Administration of H2 receptor antagonist with proton pump inhibitor is effective for long-term control of refractory reflux esophagitis. J Clin Gastroenterol 38:297-298, 2004
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P.187 掲載の参考文献
1) Hongo M, Shoji T:Epidemiology of reflux disease and CLE in East Asia. J Gastroenterol 38:25-30, 2003
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2) Wuesten BI, Roelofs JM, Akkermans LM et al:The symptom-association probability:an improved method for symptom analysis of 24-hour esophageal pH data. Gastroenterology 107:1741-1745, 1994
 
3) GERD 研究会:GERD ガイドラインワークショップレポート2002, エム・シー・アンド・ピー, 大阪, 2002
 
4) 本郷道夫, 田村太作:非びらん性胃食道逆流症. 日本臨牀 62:1565-1569, 2004
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5) Hongo M, Kanatsuka H, Sugawara A et al:Primary care in the treatment of functional gastrointestinal symptoms in Japan:prescription preferences and impression of results. Aliment Pharmacol Ther 21:47-54, 2005
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P.198 掲載の参考文献
1) GERD ガイドラインワークショップレポート 2002, GERD 研究会発行, 2002
 
2) 本郷道夫:GERDに対する薬物療法-GERD の治療とガイドライン-. 消内視鏡 15:1685-1699, 2003
 
3) 羽生泰樹:GERD の薬物治療. 消臨 8:311-317, 2005
 
4) 天野和寿, 木下芳一:VI. 胃食道逆流症の治療2. 薬物療法. 日内会誌 89:68-73, 2000
 
5) Chiba N, De Gara CJ, Wilkinson JM et al:Speed of healing and symptom relief in grade II to IV gastroesophageal reflux disease:ameta-analysis. Gastroenterology 112:1798-1810, 1997
 
6) DeVault KR, Castell DO:Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. Am J Gastroenterol 100:190-200, 2005
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7) Dekkers CP, Beker JA, Thjodleifsson B et al:Double-blind comparison[correction of Double-blind, placebo-controlled comparison]of rabeprazole 20 mg vs. omeprazole 20 mg in the treatment of erosive or ulcerative gastro-oesophageal reflux disease. Aliment Pharmacol Ther 13:49-57, 1999
 
8) Katzka DA, Paoletti V, Leite L et al:Prolonged ambulatory pH monitoring in patients with persistent gastroesophageal reflux disease symptoms:testing while on therapy identifies the need for more aggressive anti-reflux therapy. Am J Gastroenterol 96:2110-2113, 1996
 
9) Peghini PL, Katz PO. Bracy NA et al:Nocturnal recovery of gastric acid secretion with ice-daily dosing of proton pump inhibitors. Am J Gastroenterol 93:763-767, 1998
 
10) Katz PO, Anderson C, Khoury R et al:Gastro-oesophageal reflux associated with nocturnal gastric acid breakthrough on proton pump inhibitors. Aliment Pharmacol Ther 12:1231-1234, 1998
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11) Katsube T, Adachi K, Kawamura A et al:Helicobacter pylori infection influences nocturnal gastric acid breakthrough. Aliment pharmacol Ther 14:1049-1056, 2000
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12) Peghini PL, Katz PO, Castell DO:Ranitidine controls nocturnal gastric acid breakthrough on omeprazole:acontrolled study in normal subjects. Gastroenterology 115:1335-1339, 1998
 
13) Horai Y, Nakano M, Ishizaki T et al:Metoprolol and mephenytoin oxidation polymorphisms in Far Eastern Oriental subjects:Japanese versus mainland Chinese. Clin Pharmacol Ther 46:198-207, 1989
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14) Ishizaki T, Horai Y:Cytochrome P 450 and the metabolizer of proton pump inhibitors-emphasis on rabeprazole. Aliment Pharmacol Ther 13 (suppl 3) 27-36, 1999
 
15) Furuta T, Ohashi K, Kamata T et al:Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer. Ann Intern Med 129:1027-1030, 1998
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16) Furuta T, Ohashi K, Kosuge K et al:CYP2C19 genotype status and effect of omeprazole on intragastric pH in humans. Clin Pharmacol Ther 65:552-561, 1999
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17) Adachi K, Katsube T, Kawamura A et al:CYP2C19 genotype status and intragastric pH during dosing with lansoprazole or rabeprazole. Aliment Pharmacol Ther 14:1259-1266, 2000
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18) Kawamura M, Ohara S, Koike T et al:The effects of lansoprazole on erosive reflux oesophagitis are influenced by CYP2C19 polymorphism. Aliment Pharmacol Ther 17:965-973, 2003
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19) Ahizumi K, Ohara S, Koike T et al:The therapeutic effects of rabeprazole at a dose of 10mg on reflux esophagitis was not influenced by the CYP2C19 polymorphism. J Gastroenterol Hepatol (in press)
 
20) Ohkusa T, Maekawa T, Arakawa T et al:Effect of CYP2C19 polymorphism on the safety and efficacy of omeprazole in Japanese patients With recurrent renux oseophagitis. Aliment Pharmacol Ther 21:1332-1339, 2005
 
21) Martinek J, Kuzela L, Spicak A et al:Review article:the clinical influence of Helicobacter pylori in effective acid suppression-implications fbr the treatment of gastro-oesophageal reflux disease. Aliment Pharmacol Ther 14:979-990, 2000
 
22) Verdu EE Armstrong D, Fraser R et al:Effect of Helicobacter pylori status on intragastric pH during treatment with omeprazole. Gut 36:539-543, 1995
 
23) Gillen D, Wirz AA, Neithercut WD et al:Helicobacter pylori infection potentiates the irlhibition of gastric acid secretion by omeprazole. Gut 44:468-475, 1999
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24) Verdu EE Armstrong D, Idstrom Jp et al:Effect of curing Helicobacter pylori infection on intragastric pH during treatment with omeprazole. Gut 37:743-748, 1995
 
25) Schenk BE, Kuipers EJ, Klinkenberg-Knol EC et al:Helicobacter pylori and the efficacy of omeprazole therapy for gastroesophageal reflux disease. Am J Gastroenterol 94:884-887, 1999
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26) Talley NJ, Meineche-Schmidt V, Pare P et al:Efficacy of omeprazole in functional dyspepsia:double-blind, randomized, placebo-controlled trials (the Bond and Opera studies). Aliment Pharmacol Ther 12:1055-1065, 1998
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27) Holtmann G, Cain C, Malfertheiner P:Gastric Helicobacter pylori infection accelerates healing of reflux esophagitis during treatment with the proton pump inhibitor pantoprazole. Gastroenterology 117:11-16, 1999
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30) Vigneri S, Termini R, Leandro G et al:Acomparison of five maintenance therapies for reflux esophagitis. N Engl J Med 333:1106-1110, 1995
 
31) Fennerty MB, Castell D, Fendric AM et al:The diagnosis and treatment of gastroesophageal reflux disease in a managed care enviroment, suggested disease managements guidelines. Arch Intern Med 156:477-484, 1990
 
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33) 羽生泰樹, 池浦司, 浦井俊二ほか:コストベネフィットからみた GERD 治療におけるプロトンポンプ阻害薬の有用性. プロトンポンプ阻害薬のすべて, 浅香正博, 千葉勉編, 先端医学社, 東京, 2002, pp.153-158
 
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38) 樋口達也, 草野元康:内視鏡経過観察の実際. 消臨 8:306-309, 2005
 
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42) 永野公一, 久保光彦, 後藤守孝ほか:GERD の診断に関する研究-上部消化管症状を訴える患者におけるアンケート (QUEST) による検討-. 新薬と臨 47:841-851, 1998
 
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PART7. Helicobacter pylori除菌治療におけるプロトンポンプ阻害薬の臨床的意義を探る

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23) 桑山肇, 吉田俊一, 中村武史ほか:オメプラゾール, アモキシシリン, およびクラリスロマイシンの3剤併用による Helicobacter pylori 除菌療法の第III相二重盲検比較試験. 第7回日本ヘリコバクター学会抄録集, 2001, p.155
 
24) Miwa H, Ohkura R, Murai T et al:Impact of rabeprazole, a new proton pump inhibitor, in triple therapy for Helicobacter pylori infection-comparison with omeprazole and lansoprazole. Aliment Pharmacol Ther 13:741-746, 1999
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9) Wong BC, Lam SK, Wong WM et al:Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China:arandomized controlled trial. JAMA 291:187-194, 2004
 
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4) 高橋信一:これでわかるピロリ除菌療法と保険適用-ガイドラインに基づく活用法-, 南江堂, 東京, 2001
 
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5) Alarcon T, Domingo D, Lopez-Brea M:Antibiotic resistance problems with Helicobacter pylori. Int J Antimicrob Agents 12:19-26, 1999
 
6) 日本化学療法学会 抗菌薬感受性測定委員会:ヘリコバクターピロリ委員会:Helicobacter pylori 除菌療法における clarithromycin (CAM) および amoxicillin (AMPC) のブレイクポイント制定に関する報告書. 日化療会誌 48:561-567, 2000
 
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8) Kato M, Yamaoka Y, Kim JJ et al:Regional differences in metronidazole resistance and increasing clarithromycin resistance among Helicobacter pylori isolates from Japan. Anti-microb Agents Chemother 44:2214-2216, 2000
 
9) 村上和成, 佐藤竜吾, 藤岡利生ほか:特集 胃・十二指腸潰瘍-基礎・臨床の最新傾向-二次除菌療法. 日臨 62:489-494, 2004
 
10) Murakami K, Sato R, Okimoto T et al:Eradication rates of clarithromycin-resistant Helicobacter pylori using either rabeprazole or lansoprazole plus amoxicillin and clarithromycin. Aliment Pharmacol Ther 16:1933-1938, 2002
 
11) 村上和成, 加藤元嗣, 加藤晴一ほか:わが国における薬剤耐性 Helicobacter Pylori の現状-平成14年度耐性菌サーベイランスの集計報告-. 日本ヘリコバクター学会誌 6:42-47, 2004
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16) Shimoyama T, Fukuda S, Mikami T et al:Efficacy of metronidazole for the treatment of clarithromycin-resistant Helicobacter pylori infection in a Japanese population. J Gastroenterol 39:927-930, 2004
 
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2) Kato M, Hokari K, Kagaya H et al:Traditional and non-traditional antimicrobial agents for H. pylori infection. Curr Pharm Des 6:1575-1581, 2000
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3) Nagata K, Satoh H, Iwahi T et al:Potent inhibitory action of the gastric proton pump inhibitor lansoprazole against urease activity of Helicobacter pylori:unique action selective for H. pylori cells. Antimicrob Agents Chemother 37:769-774, 1993
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6) El-Nujumi A, Hilditch TE, Williams C et al:Current or recent proton pump inhibitor therapy markedly impairs the accuracy of the 14C-urea breath test. Eur J Gastroenterol Hepatol 10:759-764, 1998
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7) Laine L, Estrada R, Trujillo M et al:Effect of proton pump inhibitor therapy on diagnostic testing for Helicobacter pylori. Ann Intern Med 129:547-550, 1998
 
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PART8. プロトンポンプ阻害薬の使い方と注意点

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7) Rindi G, Fiocca R, Morocutti A et al:Effects of 5 years of treatment with rabeprazole or omeprazole on the gastric mucosa. Eur J Gastroenterol Hepatol 17:559-566, 2005
 
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2) Delhotal-Landes B, Cournot A et al:The effect of food and artacid on lansoprazole absorption and sisposition. Eur J Drg Metab Pharmacikinet 3:315, 1991
 
3) Humphries TJ:clinical implications of drug interactions with the cytochrome P-450 enzyme system associated with omeprazple. Dig Dis Sci 36:1665-1669, 1991
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4) 三輪清, 三谷政義, 塚本剛司 ほか:新規プロトンポンプ阻害剤 AG-1749 のラット, マウス, イヌにおける生体内動態. 薬理と治療 18:3413, 1990
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5) 吉田隆久:H. pylori 除菌療法とPPI-CYP2C19 の遺伝子的多型との関連より-. ヘリコバクター・ピロリ・フォーラム 病態と治療の最前線, 藤岡利生, 榊信廣編, 医学書院, 東京, 2000, pp.110-117
 
6) Ishizaki T, Horai Y:Review article;cytochrome p450 and the mechanism of proton pump inhibitors-emphasis on rabeprazole. Aliment Pharmacol Ther 13 (suppl 3):S 527-S536, 1999
 
7) 岡崎和一:プロトンポンプ阻害薬の薬物間相互作用で知っておくべき知識は何か, 浅香正博, 千葉勉編, プロトンポンプ阻害薬のすべて, 先端医学社, 東京, 2002, pp.231-233
 
8) Kokuhu T, Ihara N, Sugioka N et al:Effects of lansoprazole on pharmacokinetics and metabolisms of theophylline. Eur J Clin Pharmacol 48:391-395, 1995
 
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1) 羽生泰樹:日本における逆流性食道炎治療の費用効果分析:(1) PPI first strategy と step-up strategy, (II) 維持療法における PPI と H2RA の比較評価. Ther Res 22:1067-1071, 2001
 
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3) 羽生泰樹, 渡邊能行, 川井啓市:GERD 治療の医療経済. Medicina 42:22-24, 2005
 
4) 羽生泰樹:GERD ガイドラインステートメント治療5. GERD ガイドラインワークショップレポート2002, GERD研究会, 2002, p.54
 
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6) 羽生泰樹:逆流性食道炎治療に関する実態調査-逆流性食道炎患者と医師へのアンケート調査から-. Prog Med 24:1133-1145, 2004
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