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> アレルギーと神経ペプチド　Vol.4　2008

アレルギーと神経ペプチド　Vol.4　2008

出版社：	日本医学館
著者：	アレルギーと神経ペプチド研究会／編
発行日：	2008-02-23
分野：	臨床医学：内科 > アレルギー
ISBN：	9784890446490
電子書籍版：	2008-02-23

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本特集は、第4回“アレルギーと神経ペプチド”編集会議（2007年11月）での内容を、その後おのおの執筆してまとめたものである。

目次

アレルギーと神経ペプチド　Vol.4　2008

―目次―

PRESENTATION
　鼻粘膜における神経ペプチドの役割

COMMENT & IMPRESSIOｎ
　アレルギー疾患の病態におけるTRPV1の位置付け
　鼻粘膜における神経ペプチド
　One airway, one diseaseと神経原性炎症
　鼻粘膜における神経ペプチドの局在とその役割
　神経ペプチドと鼻粘膜過敏性亢進
　神経ペプチドと皮膚粘膜の恒常性
　鼻粘膜における検討から皮膚アレルギー反応における
　　神経ペプチドの役割を考える

この書籍の参考文献

参考文献のリンクは、リンク先の都合等により正しく表示されない場合がありますので、あらかじめご了承下さい。

本参考文献は電子書籍掲載内容を元にしております。

特集 "鼻粘膜における神経ペプチド"

P.7 掲載の参考文献

1) Shirasaki H, Watanabe K, Kanaizumi E, Sato J, Konno N, Narita S,Himi T: Effects of cetirizine on substance P release in patients with perennial allergic rhinitis. Ann Otol Rhinol Laryngol 2004, 113:941-945.

2) Bai TR, Zhou D, Weir T, Walker B, Hegele R, Hayashi S, McKay K,Bondy GP, Fong T: Substance P(NK1)- and neurokinin A(NK2)-receptor gene expression in inflammatory airway diseases. Am J Physiol 1995, 269(3 Pt 1):L309-317.

3) Shirasaki H, Asakura K, Narita S, Kataura A: Expression of substance P(NK1)receptor mRNA in human nose. Acta Otolaryngol 1998, 118:717-722.

4) Shirasaki H, Kanaizumi E, Watanabe K, Konno N, Sato J, Asakura K,Kataura A, Himi T:Expression of neurokinin A(NK2)receptor mRNA in human nasal mucosa. Acta Otolaryngol (Stockh) 2004, 124(Suppl 553):85-89.

5) Shirasaki H, Asakura K, Narita S, Watanabe M, Kataura A: The effects of NK1 receptor antagonists (FK224 and FK888) on agonistand antigen-induced nasal microvascular leakage in guinea pigs. Inflamm Res 1997, 46:28-31.

6) Stjarne P, Rinder J, Heden-Blomquist E, Cardell LO, Lundberg J, Zetterstrom O, Anggard A: Capsaicin desensitization of the nasal mucosa reduces symptoms upon allergen challenge in patients with allergic rhinitis. Acta Otolaryngol (Stockh) 1998, 118:235-239.

7) Blom HM, Van Rijswijk JB, Garrelds IM, Mulder PG, Timmermans T,Gerth van Wijk R: Intranasal capsaicin is efficacious in non-allergic, non-infectious perennial rhinitis. A placebo-controlled study. Clin Exp Allergy 1997, 27:796-801.

8) Gerth Van Wijk R, Terreehorst IT, Mulder PG, Garrelds IM, Blom HM, Popering S: Intranasal capsaicin is lacking therapeutic effect in perennial allergic rhinitis to house dust mite. A placebo-controlled study. Clin Exp Allergy 2000, 30:1792-1798.

9) Seki N, Shirasaki H, Kikuchi M, Sakamoto T, Watanabe N, Himi T: Expression and localization of TRPV 1 in human nasal mucosa. Rhinology 2006, 44:128-134.

P.10 掲載の参考文献

1) Shirasaki H et al.: Effects of cetirizine on substance P release in patients with perennial allergic rhinitis. Ann Otol Rhinol Laryngol 2004, 113:941-945.

2) Katelijne O et al.: Extending the understanding of sensory neuropeptides. Eur J Pharmacol 2006, 533:171-181.

P.16 掲載の参考文献

1) 亀好良一, 秀広:膨疹とその形成機序. 最新皮膚科学大系3. 中山書店, 2002, p188-195.

2) 秀道広:2004年私の仮説. 連鎖反応閾値説. 日皮会誌 2004, 114:2021-2026.

3) 山本昇壯, 高路修, 秀道広:皮膚におけるアレルギーと神経との相互作用. アレルギー科 1998, 5:61-67.

4) Toyoda M, Nakamura M, Makino T et al.: Nerve growth factor and substance P are useful plasma markers of disease activity in atopic dermatitis. Br J Dermatol 2002, 147:71-79.

5) 秀道広, 岡部勉, 山本昇壯:神経ペプチドと皮膚アレルギー. アレルギー科 2001, 11:419-426.

6) Inoue K et al.: Functional vanilloid receptors in cultured normal human epidemial keratinocytes. Biochem Biophys Res Commun 2002,291:124-129.

REVIEW & TOPICS

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1) 今野昭義:鼻過敏症-その病態と臨床. 第97回日本耳鼻咽喉科学会総会宿題報告, 1996, モノグラフ:千葉大学医学部耳鼻咽喉科教室.

2) Sarin S et al.: The role of the nervous system in rhinitis. J Allergy Clin Immunol 2006, 118:999-1014.

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1) Global initiative for asthma. National Institute of Health publication 1995, 95:3569.

2) Concha M, Vidal MA, Moreno I et al.: Evidence for modulation of human epidermal differentiation and remodelling by CD40. Br J Dermatol 2003, 148:1105-1114.

3) Mihm MC Jr, Soter NA, Dvorak HF, Austen KF: The structure of normal skin and the morphology of atopic eczema. J Invest Dermatol 1976, 67:305-312.

4) Bae SJ, Tanaka Y, Ogawa F et al.: Inhibitory effect of cetirizine on histamine induced eotaxin production in normal human fibroblasts. Current Therap Res 2002, 63:128-140.

5) Bae SJ, Matsunaga Y, Tanaka Y, Katayama I: Autocrine induction of substance P mRNA and peptide in cultured normal human keratinocytes. Biochem Biophys Res Commun 1999, 263:327-333.

6) Levi-Schaffer F, Garbuzenko E, Rubin A et al.: Human eosinophils regulate human lung- and skin-derived fibroblast properties in vitro: a role for transforming growth factor beta (TGF-beta). Proc Natl Acad Sci USA 1999, 96:9660-9665.

7) Puxeddu I, Bader R, Piliponsky AM et al.: The CC chemokine eotaxin/CCL11 has a selective profibrogenic effect on human lung fibroblasts. J Allerg Clin Immuno 2006, 117:103-110.

8) Gomes I, Mathur SK, Espenshade BM et al.: Eosinophil fibroblast interactions induce fibroblast IL-6 secretion and extracellular matrix gene expression:implications in fibrogenesis. J Allergy Clin Immunol 2005, 116:796-804.

9) Katayama I, Nishioka K: Substance P augments fibrogenic cytokine-induced fibroblast proliferation:possible involvement of neuropeptide in tissue fibrosis. J Dermatol Sci 1997,15:201-206.

10) 片山一朗, 室田浩之 : 線維芽細胞, 皮膚免疫ハンドブック. (玉置邦彦, 塩原哲夫・編), 中外医学社, 2005, p79-87.

11) 平井浩一: Eotaxin, eotaxin 2, eotaxin 3. ケモカインハンドブック 2001. (義江修, 野見山尚之, 宮坂昌幸・監修), 秀潤社, p78-83.

12) Rook GA: The TGF-betal paradox in asthma. Trends Immunol 2001, 22:299-300.

13) 豊原辰之, 石崎雅之, 梶原大輔・他 : 抗TGFβ抗体の気道リモデリング形成に及ぼす影響. 日本アレルギー学会雑誌 2003, 52:907.

14) Hoeck J, Woisetschlager M: STAT6 mediates eotaxin-1 expression in IL-4 or TNF-alpha-induced fibroblasts. J Immunol 2001, 166:4507-4515.

15) Murota H, Hamasaki Y, Katayama I et al.: Emedastine difumarate inhibits histamine-induced collagen synthesis in dermal fibroblasts. J Investig Allergol Clin Immunol, (in press).

P.28 掲載の参考文献

1) 吉原重美 : 気管支喘息における神経ペプチド. アレルギーの臨床 2005, 25:1014-1019.

2) 吉原重美 : I 基礎, DSCGのC-fiber活性抑制作用. アレルギー・免疫 2005, 12:1138-1144.

3) 阿部利夫, 吉原重美 : 気管支喘息と神経ペプチド. アレルギー・免疫 2007, 14:878-883.

4) Yoshihara S,Morimoto H, Yamada Y et al.: Cannabinoid receptor agonists inhibit sensory nerves activation in guinea-pig airways. Am J Respir Crit Care Med 2004, 170:941-946.

5) Yoshihara S, Morimoto H, Yamada Y et al.: Endogenous cannabinoid receptor agonists inhibit neurogenic inflammations in guinea-pig airway. Int Arch Allergy Immunol 2005, 138:80-87.

6) Yoshihara S, Morimoto H, Arisaka O et al.: The cannabinoid receptor agonist WIN55212-2 inhibits neurogenic inflammation in airway tissues. J Pharmacol Sci 2005, 98:77-82.

7) Baulieu EE: Neurosteroids: of the nervous system, by the nervous system, for the nervous system(review). Rec Progr Hormone Res 1997,52:1-32.

8) Ffrench-Mullen JMH, Danks P, Spence, KT: Neurosteroids modurate calcium currents in hippocampal CA1 neurons via a pertussis toxin-sensitive G-protein-coupled mechanism. J Neurosci 1994, 14:1963-1997.

9) Yoshihara S, Morimoto H, Yamada Y et al.: A neuroactive steroid, allotetrahydrocorticosterone inhibits sensory nerves activation in guinea-pig airways. Neurosci Res 2005, 53:210-215.

10) Yoshihara S, Morimoto H, Arisaka O et al.: A neuroactive steroid inhibits guinea-pig airway sensory nervesvia Maxi-K+channels activation. Int Arch Allergy Immunol 2006, 141:31-36.

P.32 掲載の参考文献

1) Mosimann BL, White MV, Hohman RJ et al.: Substance P,calcitonin gene-related peptide, and vasoactive intestinal peptide increase in nasal secretions after allergen challenge in atopic patients. J Allergy Clin Immunol 1993, 92:95-104.

2) Wu X, Myers AC, Goldstone AC et al.: Localization of nerve growth factor and its receptors in the human nasal mucosa. J Allergy Clin Immunol 2006, 118:428-433.

3) Abe Y, Takeda N, Irifune M et al.: Effects of capsaicin desensitization on nasal allergy-like symptoms and histamine release in the nose induced by toluene diisocyanate in guinea pigs. Acta Otolaryngol 1992, 112:703-709.

4) Wilfong ER, Dey RD:Nerve growth factor and substance P regulation in nasal sensory neurons after toluene diisocyanate exposure. Am J Respir Cell Mol Biol 2004, 30:793-800.

5) Heppt W, Dinh QT, Cryer A et al.: Phenotypic alteration of neuropeptide-containing nerve fibres in seasonal intermittent allergic rhinitis. Clin Exp Allergy 2004,34:1105-1110.

6) Wilfong ER, Dey RD:The release of nerve growth factor from the nasal mucosa following toluene diisocyanate. J Toxicol Environ Health A 2005, 68:1337-1348.

7) Baraniuk JN, Lundgren JD, Okayama M et al.: Substance P and neurokinin A in human nasal mucosa. Am J Respir Cell Mol Biol 1991,4:228-236.

8) Sanico AM, Koliatsos VE, Stanisz AM et al.: Neural hyperresponsiveness and nerve growth factor in allergic rhinitis. Int Arch Allergy Immunol 1999, 118:154-158.

9) 福井裕行:ヒスタミンH1受容体遺伝子発現機構を標的とするアレルギー疾患治療薬の意義. Yakugaku Zasshi 2007, 127: 15-25.

10) Sugimoto Y, Ogasawara R, Watanabe T et al. Inhibitory effect of olopatadine on nasal rubbing induced by capsaicin in histamine H1 receptor-deficient and mast cell-deficient mice. J Pharmacol Sci 2004, 94 (Suppl I):203.

11) Tamura T, Amano T, Ohmori K et al.: The effects of olopatadine hydrochloride on the number of scratching induced by repeated application of oxazolone in mice. Eur J Pharmacol 2005, 524:149-154.

EDUCATIONAL LECTURE

P.40 掲載の参考文献

1) 馬場康太郎・他 : 鼻アレルギー診療ガイドライン-通年性鼻炎と花粉症. 改訂第5版. ライフサイエンスメディカ, 2005.

2) 鵜飼幸太郎 : 鼻粘膜過敏性試験. 臨床免疫 1988, 20(Suppl 13):276-283.

3) Fang SY, Syen CL:Neuropeptide innervation and neuroendocrine cells in allergic rhinitis and chronic hypertrophic rhinitis. Clin Exp Allergy 1997, 28:228-232.

4) Heppt W, Thai Dinh Q, Cryer A et al.: Phenotypic alteration of neuropeptide-containing nerve fibers in seasonal intermittent allergic rhinitis. Clin Exp Allergy 2004, 34:1105-1110.

5) Mosimann BL, White MV, Hohman RJ et al.: Substance P,calcitonin gene-related peptide, and vasoactive intestinal peptide increase in nasal secrections after allergen challenge in atopic patients. J Allergy Clin Immunol 1993, 92:95-104.

6) Tanaka K, Okamoto Y, Nagaya Y et al.: A nasal allergy model developed in the guinea pig by intranasal application of 2,4-toluene diisocyanate. Int Arch Allergy Appl Immunol 1998, 85:392-397.

7) Kitamura Y, Miyoshi A, Murata Y et al.: Effect of glucocorticoid on upregulation of histamine H1 receptor mRNA in nasal mucosa of rats sensitized by exposure to toluene diisocyanate. Acta Otolaryngol 2004, 124:1053-1058.

8) Kalubi B, Takeda N, Irifune M, Ogino S, Abe Y et al.: Nasal mucosa sensitization with toluene diisocyanate (TDI) increases preprotachykinin A (PPTA) and preproCGRP mRNAs in guinea pig trigeminal ganglion neurons. Brain Res 1992, 576:287-296.

9) Tani E, Senba E, Kokumai S, Masuyama K, Ishikawa T et al.: Histamine application to the nasal mucosa induces release of calcitonin gene-related peptide and substance P from peripheral terminals of trigeminal ganglion: a morphological study in the guinea pig. Neurosci Lett 1990, 112:1-6.

10) Tohyama M, Senba E, Noguchi K, Swansson LW: Different responses in neuropeptide biosynthesis of axotomized dorsal root ganglion cells :An analysis using in situ hybridization histochemistry. Biomed Res Suppl 1989,10:11

11) Abe Y, Ogino S, Irifune M, Imamura I, Liu YQ et al.: Histamine content, synthesis and degradation in nasal mucosa and lung of guinea-pigs treated with toluene diisocyanate (TDI). Clin Exp Allergy 1993, 23:512-517.

12) 入船盛弘 : モデル動物を用いた鼻過敏症病態の研究交感神経系の役割について. 耳鼻咽喉科臨床 1989, 82(5):719-727.

13) Abe Y, Takeda N, Irifune M, Ogino S, Kalubi B et al.: Effects of capsaicin desensitization on nasal allergy-like symptoms and histamine release in the nose induced by toluene diisocyanate in guinea pigs. Acta Otolaryngol 1992, 112:703-709.

14) Chen SE, Bernstein IL: The guinea pig model of diisocyanate sensitization. 1. Immunologic studies. J Allergy Clin Immunol 1982, 70:383-392.

15) Shanahan F, Denburg JA, Fox J, Bienenstock J, Befus D: Mast cell heterogeneity:effects of neuroenteric peptides on histamine release. J Immunol 1985, 135:1331-1337.

16) Takeda N, Kalubi B,Abe Y, Irifune M, Ogino S et al.: Neurogenic inflammation in nasal allergy : histochemical and phamiacological studies in guinea pigs. Acta Otolaryngol. Suppl 1993, 501:21-24.

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19) Chatelain C, Pochon N, Lacroix JS.Chatelain C, Pochon N et al.: Functional effects of phosphoramidon and captopril on exogenous neuropeptides in human nasal mucosa. Eur Arch Otorhinolaryngol 1995,252:83-85.

20) Lilly CM, Kobzik L, Hall AE, Drazen JM: Effects of chronic airway inflammation on the activity and enzymatic inactivation of neuropeptides in guinea pig lungs. J Clin Invest 1994, 93:2667-2674.

21) 間島雄一, 原田輝彦, 郭永清, 坂倉康夫 : ニューロキニンAの鼻粘膜過敏性亢進における役割. 耳展 1996, 39(補2):132-136.

22) Das AK, Yoshimura S, Mishima R, Fujimoto K, Mizuguchi H et al.: Stimulation of histamine H1 receptor up-regulates histamine H1 receptor itself through activation of receptor gene transcription. J Pharmacol Sci 2007, 103:374-382.

23) Iriyoshi N, Takeuchi K, Yuta A et al.: Increased expression of histamine H1 receptor mRNA in allergic rhinitis. Clin exp Allergy 1996,26:379-385.

24) Hamano N, Terada N, Maesako K et al.: Expression of histamine receptors in nasal epithehal cells and endothelial cells-the effects of sex hormones. Int Arch Allergy Immunol 1998, 115:220-227.

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26) Ishibe T, Kubo N, Kumazawa H et al.: Histamine H1 receptors and affinity analysis in human nasal mucosa in case of nasal allergy. Ann Otol Rhinol Laryngol 1985, 94:186-190.

27) Leurs R, Bast A, Timmerman H: High affinity, saturable [3H] mepyramine binding sites on rat liver plasma membrane do not represent histamine H1-receptors. Biochemical Pharmacol 1989, 38:2175-2180.

28) 黒田若奈, 秦野昌弥, 宮本裕子, 北村嘉章, 福井裕行, 武田憲昭 : ヒスタミンH1受容体拮抗薬の初期療法における鼻粘膜H1受容体, Il-4遺伝子発現の抑制 : TDIモデル動物を用いた研究. 日鼻学会誌 2007, 46:280.

DRUG-REPORT

P.51 掲載の参考文献

1) Akira S, Uematsu S, Takeuchi O: Pathogen recognition and innate immunity. Cell 2006, 124:783-801.

2) Takeda K, Kaisho S, Akira S: Toll-like receptors. Annu Rev Immunol 2003,21:335-376.

3) Kline JN, Waldschmidt TJ, Businga TR, Lemish JE, Weinstock JV, Thome PS et al.: Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma. J Immunol 1998, 160:2555-2559.

4) Creticos PS, Schroeder JT, Hamilton RG, Balcer-Whaley SL, Khattignavong AP, Lindblad R et al.: Immunotherapy with a ragweed-Toll-like receptor 9 agonist vaccine for allergic rhinitis. N Engl J Med 2006, 355:1445-1455.

5) Patel P, Salapatek AM: Pollinex Quattro: A novel and well-tolerated, ultra short-course allergy vaccine. Expert Rev Vaccines 2006, 5:617-629.

6) Halperin SA, Dobson S, McNeil S, Langley JM, Smith B, McCallSani R et al.: Comparison of the safety and immunogenicity of hepatitis B virus surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide and a licensed hepatitis B vaccine in healthy young adults. Vaccine 2006, 24:20-26.

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