痛みの薬物治療

出版社: 文光堂
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発行日: 2013-07-03
分野: 臨床医学:外科  >  麻酔科学/ペイン
ISBN: 9784830628344
電子書籍版: 2013-07-03 (第1版第2刷)
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痛みの薬物治療に必要な基礎的知見から各薬剤の作用機序,薬物動態,鎮痛効果の特徴などに加え,痛みの種類や痛みが生じる原因ごとの鎮痛薬の選択までをビジュアルに解説.

目次

  • 表紙
  • 執筆者一覧
  • 痛みのScience & Practiceシリーズ 序文
  • 「痛みの薬物治療」序文
  • 目次
  • 総説
  • 痛み治療における薬物療法の位置づけ
  • 解説
  • I. 総論
  • 1 鎮痛薬の作用を理解するための解剖
  • 2 鎮痛薬の作用を理解するための生理
  • 1) 熱刺激がどのように情報化されるか
  • 2) 侵害受容器に対する化学刺激
  • 3) 痛み回路の可塑性メカニズム
  • 4) 下行性抑制系のメカニズム
  • 3 鎮痛薬の作用を理解するための薬理 - 主要な神経伝達物質とその受容体 -
  • 4 内臓痛のメカニズム
  • 5 炎症痛のメカニズム
  • 6 神経障害痛のメカニズム
  • 7 作用の個体差
  • [T] TRPV1阻害薬の鎮痛効果
  • II. 高齢者・小児に対する薬の使い方
  • 1 高齢者の痛みに対する薬物治療
  • 2 小児の痛みに対する薬物治療
  • III. 鎮痛薬の投与経路
  • 1 投与経路の特徴と適応
  • IV. 痛みのメカニズムとその対応
  • 1 疝痛・鈍痛
  • 2 アロディニア
  • 3 電撃痛
  • 4 しびれ
  • 5 痒み
  • V. 痛みの治療に用いる薬物の特徴
  • 1 麻薬系鎮痛薬
  • 1) 総論
  • 2) モルヒネ
  • 3) オキシコドン
  • 4) フェンタニル
  • 5) コデイン
  • 6) ペチジン
  • 7) メサドン
  • 2 拮抗性鎮痛薬
  • 1) 総論
  • 2) ペンタゾシン
  • 3) ブプレノルフィン
  • 4) エプタゾシン
  • 3 トラマドール
  • 4 非ステロイド性消炎鎮痛薬
  • 1) 総論
  • 2) COX - 1, COX - 2非選択的阻害薬
  • 3) COX - 2選択的阻害薬
  • 5 アセトアミノフェン
  • 6 ステロイド
  • 7 ケタミン
  • 8 ブチルスコポラミン
  • 9 ノイロトロピン
  • 10 ボツリヌス毒素タイプA
  • 11 漢方薬 - 選択の参考所見
  • 12 鎮痛補助薬
  • 1) 三環系抗うつ薬
  • 2) SNRI
  • 3) SSRI・NaSSA
  • 4) 抗痙攣薬
  • 5) α2δサブユニットブロッカー
  • 6) 抗不整脈薬
  • [T] Ziconotide - N型カルシウムチャネルブロッカーの可能性
  • VI. 痛みの原因と鎮痛薬の選択
  • 1 術後痛
  • 2 がん性痛
  • 1) 骨転移
  • 2) がんによる神経障害痛
  • 3) 抗がん薬による神経障害痛
  • 3 炎症痛
  • 4 神経障害痛
  • 1) 帯状疱疹後神経痛
  • 2) 幻肢痛
  • 3) 糖尿病性神経障害
  • 4) 三叉神経痛
  • 5 線維筋痛症
  • 6 CRPS
  • 7 運動器の痛み - 関節
  • 8 運動器の痛み - 筋肉
  • 9 腰痛症
  • [T] 痛み治療には薬物療法か神経ブロックか ? - 適応, 有効性を考えて ( 1 ) -
  • [T] 痛み治療には薬物療法か神経ブロックか ? - 適応, 有効性を考えて ( 2 ) -
  • 索引
  • 奥付

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総説

P.5 掲載の参考文献

解説

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