エンドトキシン研究　5

出版社： 医学図書出版
著者：
発行日： 2002-10-31
分野： 臨床医学：外科  >  麻酔科学/ペイン
ISBN： 4871513165
電子書籍版： 2002-10-31 （第1版第1刷）
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本論文集は研究会での特別講演、セミナー、シンポジウム、一般演題を集約したものであり、現時点における研究と治療の最前線が示されたと同時に、基礎と臨床におけるエンドトキシン研究に関する今後の課題も示されたものと考えている。本書が、基礎・淋症を問わず、エンドトキシンの研究に従事している全ての方々の今後の指針となれば幸いである。

目次

  • エンドトキシン研究　5

    ―　目　次　―

    第1章　特別寄稿

    第2章　エンドトキシン測定法をめぐる諸問題と展望

    第3章　Toll-like receptorならびに情報伝達

    第4章　エンドトキシンに着目した病態研究

    第5章　エンドトキシンと臓器障害

    第6章　エンドトキシン血症に対する治療戦略

    第7章　エンドトキシン血症治療への新展開

この書籍の参考文献

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本参考文献は電子書籍掲載内容を元にしております。

第1章 特別寄稿

P.7 掲載の参考文献
1) Morrison D C : Diversity of mammalian macromolecules which bind to bacterial lipopolisaccharides. In "Endotoxin Research Series 1. Cellular and Molecular Aspects of Endotoxin Reactions" eds Nowotny A, Spitzler J J, Ziegler E J, Excerpta Medica, Amsterdam, 1990, p 183-190
 
2) Tobias P S and R J Ulevitch : Control of lipopolysaccharide-high density lipoprotein binding by acute phase protein (s). J Immunol 131 : 1913-1916, 1983
 
3) Wang P, R L Kitchens and R S Munford : Phosphatidylinositides bind to plasma membrane CD 14 and can prevent monocyte activation by bacterial lipopolysaccharide. J Biol Chem 273 : 24309-24313, 1988
 
4) Reid R R, A P Prodeus, W Khan, et al : Endotoxin shock in antibody-deficient mice Unrabeling the role of natural antibody and complement in the clearance of lipopolysaccharide. J Immunol 159 : 970-975, 1997
 
5) Muller-Eberhard H J : Complement Chemistry and pathways. 2nd edition ed Inflammation : Basic Principles and Clinical Correlates, ed I. M. G. a. R. S. J. I. Gallin. Raven Press, Ltd., New York, 1992, p 33-61
 
6) Prodeus A P, X Zhou, M Maurer, et al : Impaired mast cell-dependent natural immunity in complement C 3-deficient mice. Nature 390 : 172-175, 1997
 
7) Fisher M B, A P Prodeus, A Nicholson-Weller, et al : Increased susceptibility to endotoxin shock in complement C 3 -and C 4-deficient mice is correlated by C1 inhibitor replacement. J Immunol 159 : 976-982, 1997
 
8) Kildsgaard J, T J Hollmann, K W Matthews, et al : Targeted disruption of the C3a receptor gene demonstrates a novel protective anti-inflammatory role for C3a in endotoxin-shock. J Immunol 165 : 5406-5409, 2000
 
9) Takabayashi T, E Vannier, B D CIark, et al : A new biologic role for C3a and C3a desArg Regulation of TNF-α and IL-1β synthesis. J Immunol 156 : 3455-3460, 1996
 
10) Fisher W H, M A Jagels, and T E Hugli : Regulation of IL6 synthesis in human peripheral blood mononuclear cells by C3a and C3a. J Immunol 162 : 453-459, 1999
 
11) Fisher W H, and T E Hugli : Regulation of B cell functions by C3aand C3 ades Arg. J Immunol 159 : 4279-4286, 1997
 
12) De Haas : New insight into the role of serum amyloid P component, a novel lipopolysaccharide-binding protein. Immunol and Med Microbiol 26 : 197-202, 1999
PubMed
13) de Haas C J, M J Poppelier, K P van Kessel, et al : Serum amyloid P component prevents high-density lipoprotein-mediated neutralization of lipopolysaccharide. Infect Immun 68 : 4954-4960, 2000
 
14) de Haas C J, M E van der Tol, K P Van Kessel, et al : A synthetic lipopolysaccharide-binding peptide based on amino acids 27-39 of serum amyloid P component inhibits lipopolysaccharide-induced responses in human blood. J Immunol 161 : 3607-3615, 1998
 
P.15 掲載の参考文献
1) Ikeda S, Saito H, Inoue T, et al : Malnutrition impairs CD11b/CD18 expression on circulating polymorphonuclear neutrophils and subsequent exudation into inflammatory sites in the early phase of glycogen-induced murine peritonitis. J Parenter Enteral Nutr 24 : 276-279, 2000
PubMed
2) Ikeda S, Saito H, Fukatsu K, et al : Dietary restriction impairs neutrophil exudation by reducing CD11b/CD18 expression and chemokine production. Arch Surg 136 : 297-304, 2001
PubMed
3) McCarter MD, Naama HA, Shou J, et al : Altered macrophage intracellular signaling induced by protein-calorie malnutrition. Cellular Immunol 183 : 131-136, 1998
PubMed
4) Kang W, Saito H, Fukatsu K, et al : Effects of Tyrosine kinase signaling inhibition on survival after cecal ligation and puncture in dietrestricted mice. J parenter Enter Nutr 25 : 291-298, 2001
 
5) Han I, Saito H, FukatsuU K, et al : Ex vivo fluorescence microscopy provides simple and accurate assessment of neutrophil-endothelial adhesion in the rat lung. SHOCK 16 : 143-147, 2001
 
6) Haslett C : Resolution of acute inflammation and the role of apoptosis in the tissue fate of granulocytes. Clin Sci Colch 83 : 639-648, 1992
PubMed
7) Matsuda T, Saito H, Fukatsu K, et al : Cytokine-modulated inhibition of neutrophil apoptosis at local site augments exudative neutrophil functions and reflects inflammatory response after surgery. Surgery 129 : 76-85, 2001
PubMed
8) Matsuda T, Saito H, Fukatsu K, et al : Differences in neutrophil death among b-lactam antibiotics after in vitro killing of bacteria. SHOCK 18 : 69-74, 2002
PubMed

第2章 エンドトキシン測定法をめぐる諸問題と展望

P.23 掲載の参考文献
1) Yokota M, Kambayashi J, Tanaka T, et al : Asimple turbidimetric time assay of the endotoxin in plasma. J Biochem Biophys Methods 18 : 97-104, 1989
 
2) 田村弘志, 有本やよい, 田中重則, 他 : カイネティック自動アッセイによる新しい血中エンドトキシン及び (1→3) -β-D-グルカン定量法. 医学のあゆみ 166 : 811-812, 1993
 
3) Obayashi T : Addition of perchloric acid to blood samples for colorimetric limulus test using chromogenic substrate : Comparison with conventional procedures and clinical applications. J Lab Clin Med 104 : 321-330, 1984
PubMed
4) Inada K, Endo S, Takahashi K, et al : Establishment of a new perchloric acid treatment method to allow determination of the total endotoxin content in human plasma by the Limulus test and clinical application. Microbiol Immunol 35 : 303-314, 1991
PubMed
5) Iwanaga S, Miyata T, Tokunaga F, et al : Molecular mechanism of hemolymph clotting system in Limulus. Thromb Res 68 : 1-32, 1992
PubMed
6) 土谷正和, 高岡文, 時岡伸之, 他 : 大過剰のカルボキシメチル化カードランによるG因子系阻害作用を利用したエンドトキシン特異的リムルステストの開発とその応用. 日細菌誌 45 : 903-911, 1990
 
7) 大石晴樹, 畑山泰道, 白石浩己, 他 : 並列比濁時間分析法によるエンドトキシンの自動測定. 薬学雑誌 105 : 300-303, 1985
 
8) 稲田捷也, 山下尚彦, 吉田昌男, 他 : 血漿中エンドトキシン測定における界面活性剤希釈加熱法の評価. 基礎と臨床 26 : 173-179, 1992
 
9) 土谷正和, 井上勝仁, 原田和明, 他 : 人血清アルブミンによる吸着したエンドトキシンの効果的な抽出. 防菌防黴誌 24 : 357-362, 1996
 
10) 遠藤重厚, 稲田捷也 : エンドトキシンの測定法. "エンドトキシンと病態" へるす出版, 1995, p13-39
 
11) 土谷正和 : 比濁時間分析法による血中β-グルカン測定の現状と問題点. "臨床に生かせる深在性真菌症検査法" メジカルセンス, 2002, p36-45
 
12) 稲田捷也, 遠藤重厚 : リムルス試薬を用いた血中エンドトキシンおよびβ-グルカン定量におけるカイネティック法での特異反応と非特異反応の判別. 医薬と薬学 42 : 885-897, 1999
 
13) 飛田規, 大林包幸, 泉福恭敬, 他 : 血中エンドトキシン測定の評価. エンドトキシン血症救命治療研究会誌 5 : 15-19, 2001
 
P.30 掲載の参考文献
1) 田中重則, 中村隆範, 森田隆司, 他 : "Limulus test" の反応機構 : 多糖体で活性化される新しいalternative pathway. 第28回毒素シンポジウム予稿集 : p7-12, 1981
 
2) Morita T, Tanaka S, Nakamura T, et al : A new (1→3) -β-D-glucan-mediated coagulation pathway found in Limulus amebocytes. FEBS Lett 129 : 318-321, 1981
 
3) 0bayashi T, Tamura H, Tanaka S, et al : A new chromogenic endotoxin-specific assay using recombined limulus coagulation enzymes and its clinical applications. Clin Chim Acta 149 : 55-65, 1985
 
4) 田中重則 : エンドトキシンとリムルステスト. "透析液エンドトキシンがよくわかる本" 竹沢真吾編. 東京医学社, 1995, p15-44
 
5) 田村弘志, 田中重則, 大林民典, 他 : カイネティック自動測定法によるエンドトキシンおよびβ-グルカンの二項目同時定量. "エンドトキシン測定法の進歩" 玉熊正悦監修, 嶋田絋編. 第1回日本エンドトキシン研究会事務局, 1996, p12-18
 
6) 牟田達史, 岩永貞昭 : 生体防御としての体液凝固. "無脊椎動物の生体防御"名取俊二, 野本亀久雄, 古田恵美子, 村松繁, 財団法人水産無脊椎動物研究所編. 学会出版センター, 1992, p81-109
 
7) 田村弘志, 小倉紀彦, 相沢真紀, 他 : 改良アルカリ前処理法を用いた血中エンドトキシン測定法の基礎および臨床的検討. "エンドトキシン研究 3" 山本俊輔, 小玉正智, 中野昌康編. 菜根出版, 2000, p211-218
 
8) 田村弘志, 小倉紀彦, 相沢真紀, 他 : 改良アルカリ前処理法を用いた血中エンドトキシン定量法. "エンドトキシ研究 4" 窪田達也, 小玉正智, 中野昌康編. 医学図書出版, 2001, p55-62
 
9) 小倉紀彦, 田村弘志, 相沢真紀, 他 : 改良前処理法を用いた血中エンドトキシン測定法の検討. エンドトキシン血症救命治療研究会誌 5 : 23-28, 2001
 
P.37 掲載の参考文献
1) Levin J and Bang F B : The role of endotoxin in the extracellular coagulation of Limulus blood, Bull Johns Hopkins Hosp 115 : 265-274, 1976
 
2) Iwanaga S, Morita T, Harada T, et al : Chromogenic substances for horseshoe crab clotting enzyme. Its application for the assay of bacterial endotoxins. Haemostasis 7 : 183-188, 1978
 
3) Obayashi T, Tamura H, Tanaka S, et al : A new chromogenic endotoxin-specific assay using recombined limulus coagulation enzymes and its clinical apPlications. Clin Chim Acta 149 : 55-65, 1985
 
4) Tamura H, Arimoto Y, Tanaka S, et al : Automated kinetic assay for endotoxin and (1→3) -β-D-glucan in human blood. Clin Chim Acta 226 : 109-112, 1994
 
5) Oishi H, Takaoka A, Hatayama Y, et al : Automated Limulus amebocyte lyste (LAL) test for endotoxin assay using a new Toxinometer ET-201. J parenter Sci Technol 39 : 194-200, 1981
 
6) 稲田捷也, 遠藤重厚, 吉田昌男 : エンドトキシン血症迅速診断のための新しい血漿前処理法の開発. 病態生理 12 : 381-389, 1993
 
7) Kakinuma A, Asano T, Torii H, et al : Gelation of limulus amebocyte lysate by an antitumor (1, 3) -β-D-glucan. Biochem Biophys Res Commun 101 : 434-439, 1981
 
8) 稲田捷也, 遠藤重厚 : リムルス試薬を用いた血中エンドトキシンおよびβ-グルカン定量におけるカイネティック法での特異反応と非特異反応の判別. 医学と薬学 42 : 885-897, 1999
Medical*Online
9) ACCP/SCMCC Consensus Conference Committee : Definitions for sepsis and organ failure and guidelines for the use of innovation therapies in sepsis : Chest 101 : 1644-1655, 1992/Crit Care Med 20 : 864-874, 1992
 
10) Bone RC, Fisher CJ, Clemmer P, et al : Sepsis syndrome : A valid clinical entity. Crit Care Med 17 : 389-393, 1989
PubMed
11) 遠藤重厚, 稲田捷也 : エンドトキシンと病態. へるす出版, 1995, p113
 
12) Endo S, Inada K, Inoue Y, et al : Two types of septic shock classified by the plasma levels of cytokines and endotoxin. Circ Shock 38 : 264-274, 1992
PubMed
13) Kasai T, Endo S, Inada K, et a1 : Anti-inflammatory cytokine levels in patients with septic shock. Res Commun Molecule Pathol Pharmacol 98 : 43-52, 1997
 
14) Endo S, Yamada Y, Inada K, et al : Plasma endotoxin and cytokine concentrations in patients with hemorrhagic shock. Crit Care Med 22 : 94-955, 1994
 
15) Endo S, Yamada Y, Inada K, et al : Are plasma endotoxin levels related to burn size and prognosis? Burns 18 : 486-489, 1992
PubMed
16) Yajima Y, Fukuda I, Otsuki M, et al : Nonseptic endotoxemia in cirrhotic patients. Gastroenterol Jpn 24 : 262-269, 1989
PubMed
17) Andersen LW, Baek L, Degn H, et al : Presence of circulating endotoxins during cardiac operation. J Thorac Cardiovasc Surg 93 : 115-119, 1987
PubMed
18) 中島隆之, 向井田昌之, 石橋和幸, 他 : 人工心肺手術における血中G因子系とリムルス反応物質の変動-その由来に関する検討-, 日本外科会誌 95 : 893-898, 1994
 
19) 遠藤重厚, 稲田捷也, 井上義博 : 急性膵炎の重症度に関わる因子の検討. 厚生省特定疾患重点事業-重症急性膵炎の救命率を改善するための研究班・平成10年度報告書 : 107-117, 1999
 
P.43 掲載の参考文献
1) 関口晃一編 : カブトガニの生物学. サイエンスハウス, 1984
 
2) Srimal S, Miyata T, Kawabata S, et al : The complete amino acid sequence of coagulogen isolated from Southeast Asian Horseshoe Crab : Carcinoscorpius rotundicauda. J Biochem 98 : 305-318, 1985
PubMed
3) Hoffmann J A, Kafatos F C, Janeway C A Jr, et al : Phylogenetic perspectives in innate immunity. Science 288 : 1313-1318, 1999
 
4) Iwanaga S : The molecular basis of innate immunity in the horseshoe crab. Curr Opin Immunol 14 : 87-95, 2002
PubMed
5) 川畑俊一郎, 牟田達史, 三浦芳樹, 他 : カブトガニの生体防御戦略 : ディフェンスモレキュルを中心に. "BioDefenseシリーズ 1" 日本生体防御学会編. 菜根出版, 1996, p 63-107
 
6) Cannon G W, Tsuchiya M, Rittschof D, et al : Magnesium dependence of Endotoxin-induced degradation of Limulus amebocytes. Biol Bull 171 : 330-337, 1986
 
7) Solon E, Gupta A P & Gaugler R : Signal transduction during exocytosis in Limulus polyphemus granulocytes. Dev Comp Immunol 20 : 307-321, 1996
PubMed
8) Muta T & Iwanaga S : The role of hemolymph coagulation in innate immunity. Curr Opin Immunol 8 : 41-47, 1996
PubMed
9) LeMosy E K, Hong C C & Hashimoto C : Signal transduction by a protease cascade. Trends Cell Biol 9 : 102-107, 1999
PubMed
10) Krem M M & DiCera E : Evolution of enzyme cascades from embryonic development to blood coagulation. Trends Biochem Sci 27 : 67-74, 2002
 
11) Kawabata S & Tsuda R : Molecular basis of non-self recognition by the horseshoe crab tachylectins. Biochim Biophys Acta in press.
 
12) Nagai T & Kawabata S : Alink between blood coagulation and prophenol oxidase activation in arthropod host defense. J Biol Chem 275 : 29264-29267, 2000
 
13) Nagai T, Osaki T & Kawabata S : Functional conversion of hemocyanin to phenoloxidase by horseshoe crab antimicrobial peptides. J Biol Chem : 27166-27170, 2001
PubMed

第3章 Toll - like receptorならびに情報伝達

P.48 掲載の参考文献
1) 審良静男 : Toll-like receptorsによる微生物認識. "エンドトキシン研究 4" 日本エンドトキシン研究会編. 医学図書出版, 2001, p23-32
 
2) Akira S, Takeda K, and Kaisho T : Toll-like receptors : critical proteins linking innate and acquired immunity. Nat Immunol 2 : 675-680, 2001
PubMed
3) Shimazu R, Akashi S, Ogata H, et al : MD-2, amolecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med 189 : 1777-1782, 1999
 
4) Lien E, Means T K, Heine H, et al : Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide. J Clin Invest 105 : 497-504, 2000
PubMed
5) Poltorak A, Ricciardi-Castagnoli P, Citterio S, et al : Physical contact between lipopolisaccharide and Toll-like receptor 4 revealed by genetic complementation. Proc Natl Acad Sci USA 97 : 2163-2167, 2000
 
6) Akashi S, Nagai Y, Ogata H, et al : Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition. Int Immunol 13 : 1595-1599, 2001
PubMed
7) Poltorak A, He X, Smirnova I, et al : Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice : mutations in Tlr4 gene. Science 282 : 2085-2088, 1998
PubMed
8) Ding A H, F Porteu, E Sanchez, et al : Shared actions of endotoxin and Taxol on TNF receptors and TNF release. Science 248 : 370-372, 1990
 
9) Kawai Y, Yano I, and Kaneda K : Various kinds of lipoamino acids including a novel serine-containing lipid in an opportunistic pathogen Flavobacterium. Their structures and biological activities on erythrocytes. Eur J Biochem 171 : 73-80, 1988
 
10) Shiozaki M, Deguchi N, Mochizuki T, et al : Revised structure and synthesis of flavolipin. Tetrahedron 54 : 11861-11876, 1998
 
11) Kawasaki K, Akashi S, Shimazu R, et al : Mouse Toll-like Receptor 4・MD-2 Complex Mediates Lipopolysaccharide-mimetic Signal Transduction by Taxol. J Biol Chem 275 : 2251-2254, 2000
 
12) Kawasaki K, Gomi K, and Nishijima M : Gin-22 of mouse MD-2 is essential for speciesspecific lipopolysaccharide mimetic action of Taxol. J Immunol 166 : 11-14, 2001
 
13) Takeuchi O, A Kaufmann, K Grote, et al : Cutting Edge : Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a Toll-like receptor 2- and MyD 88-dependent signaling pathway. J Immunol 164 : 554-557, 2000
 
14) Gomi K, Kawasaki K, Kawai Y, et al : Toll-like receptor 4・MD-2 complex mediates the signal transduction induced by flavolipin, an amino acid-containing lipid unique to Flavobacterium meningosepticum. J Immunol 168 : 2939-2943, 2002
 
P.54 掲載の参考文献
1) Wright SD, Ramos RA, Tobias PS, et al : CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249 : 1431-1433, 1990
PubMed
2) Haziot A, Chen S, Ferrero E, et al : The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage. J Immunol 141 : 547-552, 1988
 
3) Poltorak A, He X, Smirnova I, et al : Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice : mutations in Tlr 4 gene. Science 282 : 2085-2088, 1998
 
4) Qureshi ST, Lariviere L, Leveque G, et al : Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr 4). J Exp Med 189 : 615-625, 1999
 
5) Kirschning CJ, Wesche H, Merrill AT, et al : Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide. J Exp Med 188 : 2091-2097, 1998
 
6) Shimazu R, Akashi S, Ogata H, et al : MD-2, amolecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med 189 : 1777-1782, 1999
 
7) Miyake K, Shimazu R, Kondo J, et al : Mouse MD-1, a molecule that is physically associated with RP 105 and positively regulates its expression. J Immunol 161 : 1348-1353, 1998
 
8) da Silva CJ, Soldau K, Christen U, et al : Lipopolysaccharide is in Close Proximity to Each of the Proteins in Its Membrane Receptor Complex : Transfer from CD 14 to TLR 4 and MD-2. J Biol Chem 21129-21135, 2001
 
9) Viriyakosol S, Tobias PS, Kitchens RL, et al : MD-2 binds to bacterial lipopolysaccharide. J Biol Chem 276 : 38044-38051, 2001
PubMed
10) Ohnishi T, Muroi M, Tanamoto K : N-linked glycosylations at Asn26 and Asn114 of human MD-2 are required for toll-like receptor 4-mediated activation of NF-κB by lipopolysaccharide. J Immunol 167 : 3354-3359, 2001
 
11) Hart GW : Glycosylation. Curr Opin Cell Biol 4 : 1017-1023, 1992
PubMed
P.59 掲載の参考文献
1) Lander, ES, Rogers J, Waterston RH, et al : Initial sequencing and analysis of the human genome. Nature 409 : 860-921, 2001
PubMed
2) Venter JC, Adams MD, Myers EW, et al : The sequence of the human genome. Science 291 (5507) : 1304-1351, 2001
PubMed
3) Hayashi K, Yandell DW : How sensitive is PCR-SSCP? Hum Mutat 2 (5) : 338-346, 1993
PubMed
4) Inazuka M, Wenz HM, Sakabe M, et al : A streamlined mutation detection system : multicolor post-PCR fluorescence labeling and single-strand conformational polymorphism analysis by capillary electrophoresis. Genome Res 7 (11) : 1094-1103, 1997
PubMed
5) Sentinelli F, Romeo S, Arca M, et al : Human resistin gene, obesity, and type 2 diabetes : mutation analysis and population study. Diabetes 51 (3) : 860-862, 2002
PubMed
6) Matsubara M, Metoki H, Suzuki M, et al : Genotypes of the betaENaC gene have little influence on blood pressure level in the Japanese population. Am J Hypertens 15 (2 Pt 1) : 189-192, 2002
 
7) Sawa T, Kurahashi K, Ohara M, et al : Evaluation of antimicrobial and lipopolysaccharideneutralizing effects of a synthetic CAP 18 fragment against Pseudomonas aerzaginosa in mouse model. Infect Immun 42 : 3269-3274, 1998
 
8) Kirikae T, Hirata M, Yamasu H, et al : Protective effects of a human CAP 18-derived peptide against murine endotoxemia. Infect Immun 66 : 1861-1868, 1998
 
9) http://www.ncbi.nlmnih.gov/entrez/viewer.fcgi?dispmax=1&showndispmax=1&val=NT_027084&view=graph&from=400087&to-445043&_sfrom-426646
 
10) Lorenz E, Mira Jp, Cornish KL, et al : A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection. Infect Immun 68 : 6398-6401, 2000
PubMed
P.65 掲載の参考文献
1) Luderitz O, Freudenberg M, Galanos C, et al : Lipopolysaccharides of gram-negative bacteria. Curr Top Membr Transp 17 : 79-151, 1982
 
2) Schletter J, Heine H, Ulmer A J, et al : Molecular mechanisms of endotoxin activity. Arch Microbiol 164 : 383-389, 1995
PubMed
3) Galanos C, Luderitz O, Freudenberg M, et al : Biological activity of synthetic heptaacyl lipid Arepresenting a component of Salmonella minnesota R 595 lipid A. Eur J Biochem 160 : 55-59, 1986
 
4) Galanos C, LUderitz O, Rietschel E T, et al : Synthetic and natural Escherichia coli free lipid A express identical endotoxic activities. Eur J Biochem 148 : 1-5, 1985
PubMed
5) Kotani S, Takada H, Tsujimoto M, et al : Synthetic lipid A with endotoxic and related biological activities comparable to those of a natural lipid A from an Escherichia coli Remutant. Infect Immun 49 : 225-237, 1985
PubMed
6) Kotani S, Takada H, Takahashi I, et al : Low endotoxic activities of synthetic Salmonella-type lipid A with an additional acyloxyacyl group on the 2-amino group of beta (1-6) glucosamine disaccharide 1, 4'-bisphosphate. Infect Immun 52 : 872-884, 1986
 
7) Imoto M, Yoshimura H, Yamamoto M, et al : Chemical synthesis of phosphorylated tetraacyl disaccharide corresponding to a biosynthetic precursor of lipid A. Tetrahedron Lett 25 : 2667-2670, 1984
 
8) Imoto M, Yoshimura H, Sakaguchi S, et al : Total synthesis of Escherichia coli lipid A. Tetrahedron Lett 26 : 1545-1548, 1985
 
9) Hailman E, Lichenstein H S, Wurfel M M, et al : Lipopolysaccharide (LPS) -binding protein accelerates the binding of LPS to CD 14. J Exp Med 179 : 269-277, 1994
 
10) Wright S D, Ramos R A, Tobias P S, et al : CD 14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249 : 1431-1433, 1990
 
11) Chow J C, Young D W, Golenbock D T, et al : Toll-ike receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem 274 : 10689-10692, 1999
 
12) Muzio M, Natoli G, Saccani S, et al : The human Toll signaling pathway : divergence of nuclear factorκB and JNK/SAPK activation upstream of tumor necrosis factor receptorassociated factor 6 (TRAF 6). J Exp Med 187 : 2097-2101, 1998
 
13) Shimazu R, Akashi S, Ogata H, et al : MD-2, amolecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med 189 : 1777-1782, 1999
 
14) Hoshino K, Takeuchi O, Kawai T, et al : Toll-like receptor 4 (TLR 4) -deficient mice are hyporesponsive to lipopolysaccharide : evidence for TLR4 as the Lps gene product. J Immunol 162 : 3749-3752, 1999
 
15) Poltorak A, He X, Smirnova I, et al : Defective LPS signaling in C 3 H/HeJ and C 57 BL/10ScCr mice : mutations in Tlr4 gene. Science 282 : 2085-2088, 1998
 
16) Qureshi S T, Larivire L, Leveque G, et al : Endotoxln-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J Exp Med 189 : 615-625, 1999
 
17) Takeuchi O, Hoshino K, Kawai T, et al : Differential roles of TLR 2 and TLR 4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11 : 443-451, 1999
PubMed
18) Vogel S N, Johnson D, Perera P Y, et al : Functional characterization of the effect of the C3H/HeJ defect in mice that lack an Lpsn gene : in vivo evidence for a dominant negative mutation. J Immunol 162 : 5666-5670, 1999
PubMed
19) Tanamoto K and Azumi S : Salmonella-type heptaacylated lipid A is inactive and acts as an antagonist of lipopolysaccharide action on human line cells. J Immunol 164 : 3149-3156, 2000
 
20) Delude R L, Savedra R J, Zhao H, et al : CD 14 enhances cellular responses to endotoxin without imparting ligand-specific recognition. Proc Natl Acad Sci U S A 92 : 9288-9292, 1995
 
21) Lien E, Means T K, Heine H, et al : Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide. J Clin Invest 105 : 497-504, 2000
PubMed
22) Poltorak A, Ricciardi-Castagnoli P, Citterio S, et al : Physical contact between lipopolysaccharide and Toll-like receptor 4 revealed by genetic complementation. Proc Natl Acad Sci USA 97 : 2163-2167, 2000
PubMed
23) Kawasaki K, Akashi S, Shimazu R, et al : Mouse Toll-like receptor 4・MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol. J Biol Chem 275 : 2251-2254, 2000
 
24) Kawasaki K, Gomi K, and Nishijima M : Gln22 of mouse MD-2 is essential for speciesspecific lipopolysaccharide mimetic action of taxol. J Immunol 166 : 11-14, 2001
PubMed

第4章 エンドトキシンに着目した病態研究

P.76 掲載の参考文献
1) 高杉潔, 津久井拓, 中島敦夫, 他 : COX-2選択的阻害薬. 医薬ジャーナル 35 : 2475-2527, 1999
 
2) Levi S and Shaw-Smith C : Non-steroidal anti-inflammatory drugs : how do they damage the gut? Br J Rheumatol 33 : 605-612, 1994
PubMed
3) Johson A G and Day R O : The problems and pitfalls of NSAID therapy in the elderly (Part I). Drugs Aging 1 : 130-143, 1991
 
4) Ng S C : Non-steroidal anti-inflammatory drugs-uses and complications. Singapore Med J 33, 510-513, 1992
PubMed
5) Wright V : Historical overview of non-steroidal anti-inflammatory drugs. Br J Rheumatol 34 (Suppl. 1) : 2-4, 1995
 
6) 川合眞一 : アスピリンはIκ-Bキナーゼβを阻害する-COX阻害以外のNSAIDsの作用機序. 臨床免疫 32 : 717-720, 1999
 
7) Yamamoto Y, Yin MJ, Lin KM, et al : Sulindac inhibits activation of the NF-kappaB pathway. J Biol Chem 274 : 27307-27314, 1999
PubMed
8) Paccani SR, Boncristiano M, Ulivieri C, et al : Nonsteroidal anti-inflammatory drugs suppress T-cell activation by inhibiting p 38 MAPK induction. J Biol Chem 277 : 1509-1513, 2002
 
9) 川合眞一 : NSAIDsの分類と薬理学的特性. 医学のあゆみ 187 : 921-925, 1998
Medical*Online
10) Naito Y, Takagi T, Matsuyama K, et al : Pioglitazone, a speci丘c PPAR-gamma ligand, inhibits aspirin-induced gastric mucosal injury in rats. Aliment Pharmacol Ther 15 : 865-873, 2001
 
11) Jaradat MS, Wongsud B, Phornchirasilp S, et al : Activation of peroxisome proliferatoractivated receptor isoforms and inhibition of prostaglandin H (2) synthases by ibuprofen, naproxen, and indomethacin. Biochem Pharmacol 62 : 1587-1595, 2001
PubMed
12) 宿前利郎 : 真菌β-1, 3-グルカンの構造と生物活性. YAKUGAKU ZASSHI 120 : 413-431, 2000
 
13) Yadomae, T and Ohno N : Structure-activity relationship of immunomodulating (1→3) β-D-glucans, Recent research development in Chem. & Pharm. Sciences 1 : 23-33, 1996
 
14) Fogelmark B, Sjostrand M, Williams D, et al : Inhalation toxicity of (1→3) -β-D-glucan. Recent advances. Mediators of inflammation 6 : 263-265, 1997
 
15) Rylander R : Investigations of the relationship between disease and airborne (1→3) -β-D-glucan in building. Mediators of inflammation 6 : 275-277, 1997
 
16) Wan GH, Li CS, Guo SP, et al : An airbone mold-derived product, beta-1, 3-D-glucan, potentiates airway allergic responses. Eur J Immunol 29 : 2491-2497, 1999
PubMed
17) Yoshioka S, Ohno N, Miura T, et al : Immunotoxicity of soluble beta-glucans induced by indomethacin treatment. FEMS Immunol Med Microbiol 21 : 171-179, 1998
PubMed
18) Takahashi H, Ohno N, Adachi Y, et al : Association of immunological disorders in lethal side effect of NSAIDs on β-glucanadministered mice. FEMS Immunol Med Microb 31 : 1-14, 2001
 
19) Moriya K, Ohno N, Miura NN et al : Septic shock induced by microbial products and indomethacin. Drug Develop Res 55 : 139-148, 2002
 
20) Moriya K, Miura NN, Adachi Y, et al : Systemic inflammatory response associated with augmentation and activation of leukocytes in Candida/indomethacin administered mice. Biol Pharm Bull 25 : 816-822, 2002
PubMed
21) Noverr MC, Phare SM, Toews GB, et al : Pathogenic yeasts Crytococcus neoformans and Candida albicans produce immunomodulatory prostaglandins. Infect Immun 69 : 2957-2963, 2001
 
22) Lamacka, M and J Sajbidor : The occurence of prostaglandins and related compounds in lower organisms. Prostaglandins Leukot Essent Fatty Acids 52 : 357-364, 1995
 
23) Botha A, J Kock and S Nigam : The production of eicosanoid precusors by mucoralean fungi. Adv Exp Med Biol 433 : 227-229, 1997
 
24) Kock P, Venter A, Botha A, et al : The production of biologically active eicosanoids by yeasts. Adv Exp Med Biol 433 : 217-219, 1997
 
P.83 掲載の参考文献
1) Weil E, Felix A : Zur serologischen Diagnose des Flekfiebers. Wien Klin Wochenschr 29 : 33-35, 1916
 
2) Ormsbee O : Rickettsiae. In "Manual of Clinical Immunology" eds Lennette EH, et al, American Society for Microbiology, Washington DC, 1980, p 922-923
 
3) Castaneda MR : The antigenic relationship between Pro teus OX 19 and typhus rickettsia. J Exp Med 60 : 119-125, 1934
 
4) Osterman JV&Eiseman CS : Rickettsial indirect hemagglutination test. J Clin Microbiol 8 : 189-196, 1978
 
5) Amano K, Williams JC, &Dasch GA : Structural properties of lipopolysaccharides from Rickettsia typhi and Ricleettsia Prowazeleii and their chemical similarity to the lipopolysac. charide from Pro teus vulgaris OX 19 used in Weil-Felix test. Infect Immun 66 : 923-926, 1998
 
6) Amano K, Kyohno K, Aoki S, et al : Serological studies of the antigenic similarity between typhus group rickettsiae and Weil-Felix test antigens. Microbiol Immunol 39 : 63-65, 1995
PubMed
7) 馬原文彦, 古賀敬一, 沢田誠二, 他. わが国初の紅斑熱群リケッチア感染症. 感染症学雑誌 59 : 1165-1172, 1985
 
8) Uchiyama T, Uchida T&Walker DH : Species-specific monoclonal antibodies to Rickettsia japonica, a newly identified spotted fever group rickettsia. J Clin Microbiol 28 : 1177-1180, 1990
PubMed
9) Amano K, Fujita M & Suto T : Chemical properties of lipopolysaccharides from spotted fever group rickettsiae and their common antigenicity with lipopolysaccharides from Proteus sspecies. Infect Immun 61 : 4350-4355, 1993
 
10) Amano K, Hatakeyama H, Okuta M, et al : Serological studies of antigenic similarity between Japanese spotted fever rickettsiae and Weil-Felix test antigens. J Clin Microbiol 30 : 2441-2446, 1992
PubMed
11) Amano K, Tamura A, Ohashi N, et al : Deficiency of peptidoglycan and lipopolysaccharide components in Ricleettsia tsutsugamushi. Infect Immun 55 : 2290-2292, 1987
PubMed
12) Tamura A, Ohashi N, Urakami H, et al : Classification of 1～ickettsia tsutsugamushi in a new genus, Orientia gen. Nov., as Orientin tsutsugamushi comb. Nov. Int J system Bacteriol 45 : 589-591, 1995
 
13) Amano K, Suzuki N, Hatakeyama H, et al : The reactivity between Rickettsiae and Weil-Felix test antigens against sera of rickettsial disease patients. Acta Virol 36 : 67-72, 1992
PubMed
14) 天野憲一, 須藤恒久, 馬原文彦 : Weil-Felix反応では診断されなかった日本紅斑熱患者血清の免疫学的性質. 感染症学雑誌 69 : 420-425, 1995
 
15) Amano K, Mizushiri S, Fujii S, et al : Immunological characterization of lipopolysaccharides from Proteus strains used in Weil-Felix test and reactivity with patients sera of tsutsugamushi diseases. Microbiol Immunol 34 : 135-145, 1990
PubMed
16) Amano K, Cedzynski M, Swierzko AS, et al : Comparison of serological reactions of Rickettsiae-infected patients and rabbit anti-Pro teus OX antibodies with Proteus OX 2, OX 19 and OXK lipopolysaccharides. Arch Immunol Ther Exp 44 : 235-240, 1996
 
17) Parker RR : Rockey mountain spotted fever. J Am Med Assoc 110 : 1185-1188, 1938
 
18) Amano K, Suzuki N, Fujita M, et al : Serological reactivity of sera from scrub-typhus patients against Weil-Felix test antigens. Microbiol Immunol 37 : 927-933, 1993
PubMed
19) Elisberg BL & Bozeman FM : The rickettsiae. In "diagnostic Procedure for Viral, Rickettsial and Chlamydial Infections" eds Lennette ED, et al, American Society for Microbiology, Washington DC, 1979, p 1061-1105
 
20) Mizushiri S, Amano K, Fujii S, et al : Chemical characterization of lipopolysaccharides from Proteus strains used in Weil-Felix test. Microbiol Immunol 34 : 121-133, 1990
PubMed
21) Cedzynski M, Knirel YA, Amano K, et al : Structural and serological studies of the Oantigen of the bacterium Proteus vulgaris OX 2 (serogroup O 2) used in Weil-Felix test. Biochemistry (Moscow) 62 : 15-20, 1997
 
22) Swierzko AS, Cedzynski M, Knirel YA, et al : Structural and serological studies of the Oantigen of the bacterium Pro tezts mirabilis OXK (serogroup O 3) used in the Weil-Felix test. Biochemistry (Moscow) 62 : 21-27, 1997
 
23) Kaca W, Swierzko AS, Ziolkowski A, et al : Serological studies of an acid labile Opolysaccharide of Proteus vulgaris OX 19 lipopolysaccharide using human and rabbit antibodies. Microbiol Immunol 42 : 669-675, 1998
 
24) Senchenkova SN, Shashkov AS, Toukach FV, et al : Structure of the acid-labile galactosyl phosphate-containing O-antigen of the bacterium Proteus uvlgaris OX 19 (serogroup O 1) used in the Weil-Felix test. Biochemistry (Moscow) 62 : 461-468, 1997
 
25) Ziolkowski AZ, Shashkov AS, Swierzko AS, et al : Structures of the O-antigens of Protezts bacilli belonging to OX group (serogroup O 1-03) used in Weil-Felix test. FEBS Lett 411 : 221-224, 1997
 
P.91 掲載の参考文献
1) Moncada S, Palmer RH, Higgs EA : Nitric oxide : physiology, pathophisiology, and pharmacology. Pharmacol Rev 43 : 109-142, 1991
 
2) Thiemermann C : The role of the L-arginine : nitric oxide pathway in circulatory shock. Adv Pharmacol 28 : 45-79, 1994
 
3) MacMicking JD, Nathan C, Hom G, et al : Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 81 : 641-650, 1995
PubMed
4) Wenzel RP : The mortality of hospitalacquired bloodstream infections : need for a new vital statistic? Int J Epidemiol 17 : 225-227, 1988
PubMed
5) Hoster MK : Handicaps to host defense. Effects of hyperglycemia on C3and Candida albicans. Diabetes 39 : 271-275, 1990
 
6) Oyama Y, Kawasaki H, Hattori Y, et al : Attenuation of endothelium-dependent relaxation in aorta from diabetic rats. Eur J Phamacol 132 : 75-78, 1986
 
7) Kamata K, Miyata N, Abiru T, et al : Functional changes in vascular smooth muscle and endothelium of arteries during diabetes mellitus. Life Sciences 50 : 1379-1387, 1992
PubMed
8) Williams SB, Cusco JA, Roddy MA, et al : Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus. J Am Coll Cardiol 27 : 567-574, 1996
PubMed
9) Johnstone MT, Creager SJ, Scales KM, et al : Impaired endothelium-dependent vasodilation in patients with insulin dependent diabetes mellitus. Circulation 88 : 2510-2516, 1993
PubMed
10) Calver A, Collier J, Vallence P : Inhibition and stimulation of nitric oxide synthesis in human forearm arterial bed of patients with insulin dependent diabetes. J Clin Invest 90 : 2548-2554, 1992
 
11) Furchgott RF : Role of endothelium in response of vascular smooth mucle. Circ Res 53 : 557-573, 1983
 
12) Wakabayashi I, Hatake K, Sakamoto K : Mechanisms of ex vivo aortic hypocontractility in endotoxemic rat. Eur J phamacol 199 : 115-118, 1991
 
13) Sotoda Y, Shimazaki Y, Wakabayashi I : Nitric oxide-dependent and-independent inhibition by lipopolysaccharide of phosphoinositide hydrolysis in vascular smooth muscle. Life Sci 69 : 2845-2854, 2001
PubMed
14) Hall S, Turcato S, Clapp L : Abnormal activation of K+ channels underlines relaxation to bacterial lipopolysaccharide in rat aorta. Biochem Biophys Res Com 224 : 184-190, 1996
 
15) Takizawa S, Ozaki H, Haraki H : Interleukin-1βinduced nitric oxide-dependent and-independent inhibition of vascular smooth muscle contraction. Eur J phamacol 330 : 143-150, 1997
 
16) Sorrentino R, Bianca R, Lippolis L, et al : Involvement of ATP-sensitive potassium channels in a model of a delayed vascular hyporeactivity induced by lipopolysaccharide in rats. Br J Pharmacol 127 : 1447-1453, 1999
 
17) Cameron NE, Cotter MA : Impaired contraction and relaxation in aorta from streptozotocin-diabetic rats : role of polyol pathway. Diabetologia 35 : 1011-1019, 1992
PubMed
18) Loven D, Schedle H : Effect of insulin and oral glutathione on glutathione levels snd superoxide dismutase activities in organs of rats with streptozotocin-induced diabetes. Diabetes 35 : 503-507, 1986
 
19) Stockklauser-Farber K, Ballhausen T, Laufer A, et al : Influence of diabetes on cardiac nitric oxide synthase expression and activity. Biochem Biophys Acta 1535 : 10-20, 2000
PubMed
20) Korolkiewics R, Rekowski P, Szyk A, et al : Effect of diabetes mellitus on the contractile activity of carbachol and galanin in isolated gastric fundus strip of rats. Pharmacology 57 : 65-78, 1998
 
21) Hattori Y, Kawasaki H, Abe K, et al : Super oxide dismutase recovers altered endotheliumdependent relaxation in diabetic rat aorta. Am J Physiol 261 : H1086-1094, 1991
PubMed
22) Diederich D, Skopec J, Diederich A, et al : Endothelial dysfuncyion in mesenteric resistance arteries of diabetic rats : role of free radicals. Am J Physiol 266 : H1153-1161, 1991
 
P.99 掲載の参考文献
1) Payne C M, Glasser L, Tischer ME, et al : Programmed cell death of the normal human neutrophil : an in vitro model of senescence. Microsc Res Tech 28 : 327-344, 1994
 
2) Homburg CHE, Roos D : Apoptosis of neutrophils. Curr Opin Hematol 3 : 94-99, 1996
 
3) Chuang PI, Yee E, Karsan A, et al : Alis a constitutive and inducible Bcl-2 homologue in mature human neutrophils. Biochem Biophys Res Commun 249 : 361-365, 1998
 
4) Hachiya O, Takeda Y, Miyata H, et al : Inhibition by bacterial lipopolysaccharide of spontaneous and TNF-alpha-induced human neutrophil apoptosis in vitro. Microbiol Immunol 39 : 715-723, 1995
PubMed
5) Watson RWG, Rotstein OD, Jimenez M, et al : Augmented intracellular glutathione inhibits Fas-triggered apoptosis of activated human neutrophils. Blood 89 : 4175-4181, 1997
 
6) Moulding DA, Akgul C, Derouet M, et al : BCL-2 family expression in human neutrophils during delayed and accelerated apoptosis. J Leukoc Biol 70 : 783-792, 2001
PubMed
7) Dahlgren C, Karlsson A : Respiratory burst in human neutrophils. J Immunol Methods 232 : 3-14, 1999
PubMed
8) Kroemer G : The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat Med 3 : 614-620, 1997
PubMed
9) Prasad NK, Papoff G, Zeuner A, et al : Therapeutic preparations of normal polyspecific IgG (IVIg) induce apoptosis in human lymphocytes and monocytes : a novel mechanism of action of IVIg involving the Fas apoptotic pathway. J Immunol 161 : 3781-3790, 1998
PubMed
10) Harter L, Keel M, Hentze H, et al : Spontaneous in contrast to CD 95-induced neutrophil apoptosis is independent of caspase activity. J Trauma 50 : 982-988, 2001
 
11) Nemes E, Teichman F, Roos D, et al : Activation of human granulocytes by intravenous immunoglobulin preparations is mediated by FcγR II and FcγR III receptors. Pediatr Res 47 : 357-361, 2000
 
12) Green DR, Reed JC : Mitochondria and apoptosis. Science 281 : 1309-1312, 1998
PubMed
13) Aoshiba K, Nagai A, Konno K : Erythromycin shortens neutrophil survival by accelerating apoptosis. Antimicrob Agents Chemother 39 : 872-877, 1995
PubMed
14) Akahoshi T, Namai R, Sekiyama N, et al : Rapid induction of neutrophil apoptosis by sulfasalazine : implications of reactive oxygen species in the apoptotic process. J Leukoc Biol 62 : 817-826, 1997
PubMed
15) Yasui K, Hu B, Nakazawa T, et al : Theophylline accelerates human granulocyte apoptosis not via phosphodiesterase inhibition. J Clin Invest 100 : 1677-1684, 1997
 

第5章 エンドトキシンと臓器障害

P.105 掲載の参考文献
1) Eppihimer MJ, Russell J, Langley R, et al : Role of tumor necrosis factor and interferon gamma in endotoxin-induced E-selectin expression. Shock 11 : 93-97, 1999
PubMed
2) Memon RA, Fuller J, Moser AH, et al : In vivo regulation of acyl-CoA synthetase mRNA and activity by endotoxin and cytokines. Am J Physiol 275 : E64-72, 1998
PubMed
3) Lin E, Calvano SE, Lowry SF. Inflammatory cytokines and cell response in surgery. Surgery 127 : 117-126, 2000
 
4) Pajkrt D, Manten A, van der Poll T, et al : Modulation of cytokine release and neutrophil function by granulocyte colony-stimulating factor during endotoxemia in humans. Blood 90 : 1415-1424, 1997
PubMed
5) Lauw FN, Pajkrt D, Hack CE, et al : Proinflammatory effects of IL-10 during human endotoxemia. J Immunol 165 : 2783-2789, 2000
PubMed
6) Ujhelyi MR, Miller AW, Raibon S, et al : Endotoxemia alters splanchnic capacitance. Shock 14 : 68-72, 2000
PubMed
7) Kinoshita M, Mochizuki H, Ono S. Pulmonary neutrophil accumulation following human endotoxemia. Chest 116 : 1709-1715, 1999
PubMed
8) Seki S, Habu Y, Kawamura T, et al : The liver as a crucial organ in the first line of host defense : the roles of Kupffer cells, natural killer (NK) cells and NK 1.1 Ag+ T cells in T helper 1 immune responses. Immunol Rev 174 : 35-46, 2000
 
9) 0berholzer A, Oberholzer C, Moldawer LL : Interleukin-10 : a complex role in the pathogenesis of sepsis syndromes and its potential as an anti-inflammatory drug. Crit Care Med 30 : S58-63, 2002
 
P.115 掲載の参考文献
1) 益田昭吾 : V. 黄色ブドウ球菌の病原因子. "医学細菌学" 三輪谷俊夫監修. 菜根出版, 1989, p119-138
 
2) Todd J, Fishaut M : Toxic-shock syndrome associated with phage-group-1 Staphylococci. Lancet 2 : 1116-1118, 1978
 
3) 炭山嘉伸, 有馬陽一 : 外科病棟における院内感染とその対策. 外科 58 : 1115-1120, 1996
 
4) Boyce JM, Landry M, Deetz TR, et al : Epidemiologic studies of an outbreak of nosocomial methicillin-resistant Staphylococcus aureus infections. Infect Control 2 : 110-116, 1981
PubMed
5) 光岡知足 : "腸内細菌学" 朝倉書店, 1990, p 107-125
 
6) Berg RD, Garlington AW : Translocation of certain indigenous bacteria from the gastrointestinal tract to the mesenteric lymph nodes and other organs in a gnotobiotic mouse model. Infect Immun 23 : 403-411, 1979
 
7) Edminston CE, Condon RE : Bacterial Translocation. Surg Gynecol Obstet 173 : 73-83, 1991
 
8) 遠藤重厚, 稲田捷也 : Bacterial translocation とその周辺侵襲時のtranslocationとその意義-Contra. 集中治療 7 : 581-588, 1995
 
9) Kanwar S, Windsor ACJW, Welsh F, et al : Lack of correlation between failure of gut barrier function and septic complications after major upper gastrointestinal surgery. Ann Surg 231 : 88-95, 2000
 
10) 福島亮治, 小林暁, 沖永功太 : 臓器不全の病態と対策 5. Bacterial translocation (BT) と臓器不全. 日外会誌 99 : 497-503, 1998
 
11) Buttenschoen K, Buttenschoen DC, Berger D, et al : Endotoxemia and acute-phase proteins in major abdominal surgery. Am J Surg 181 : 36-43, 2001
PubMed
12) 炭山嘉伸 : MRSAとの格闘, 8年-第25回日本腹部救急医学会総会会長講演-. 日腹部救急医会誌 16 : 315-330, 1996
 
13) Arima Y : Rat Methicillin-Resistant Staphylococcus aureus Infection Model Demonstrating Intestinal Colonization and Bacterial Translocation. J Infect Chemother 3 : 154-159, 1997
 
14) Yoshida Y : Methicillin-Resistant Staphylococcus aureus prolifration in the rat gut is influenced by gastric acid inhibition and the administration of antibiotics. Surg Today 29 : 327-337, 1999
 
15) Nakamura Y, Aramaki Y, Kakiuchi T : A mouse model for postoperative fatal enteritis due to Staphylococcus infection. J Surg Res 96 : 35-43, 2001
PubMed
16) 保里恵一, 由良二郎, 品川長夫, 他 : 術後感染性腸炎, 特にMRSA腸炎の実態. 感染症誌 63 : 701-707, 1990
 
17) 炭山嘉伸, 草地信也 : 消化器外科手術後におけるmethicillin resistant Staphylococcus aureus感染症の対策. 日消外会誌 24 : 1262-1271, 1991.
 
18) Rimero-vivas J, Rubio M, Fernandez C, et al : Mortality associated with nosocomial bacteremia due to methicillin-resistant Staphylococcus aureus. Clin Infect Dis 21 : 1417-1423, 1995
 
19) Kusachi S, Sumiyama Y, Nagao J, et al : New methods of control against postoperative methicillin-resistant Staphylococcus aureus infection. Surg Today 29 : 724-729, 1999
PubMed
20) "院内感染対策の手引き-MRSAに注目して-" 厚生省国立病院課・国立療養所課. 南江堂, 1992
 
21) "改訂院内感染対策テキスト" 日本感染症学会編. へるす出版, 1998
 
22) "病院感染防止マニュアル" 日本環境感染学会監修. オフィスエム・アイ・ティ, 2001
 
23) "病院における隔離予防策のためのCDC最新ガイドライン" 向野賢治訳・小林寛伊監訳, メディカ出版, 1996
 
24) 草地信也 : 外科における病院感染対策の決め手. INFECTION CONTROL 4 : 468-472, 1995
 
25) 花谷勇治 : 4 呼吸器感染症. "消化器外科周術期感染症" 炭山嘉伸編. 南山堂, 1998, p177-180
 
26) Hudson IRB : The efficacy of intranasal mupirocin in the prevention of staphylococcal infections : a review of recent experience. J Hosp Infect 27 : 81-98, 1994
 
27) 炭山嘉伸 : 消化器外科感染症における腸内細菌の重要性. 日消外会誌 30 : 121-125, 1997
 
28) 炭山嘉伸, 横山隆 : 消化器外科における抗生剤の使用法をめぐって. 日消外会誌 27 : 2358-2367, 1994
 
29) 品川長夫, 真下啓二, 岩井重富, 他 : 術後感染予防についてのアンケート報告. 日消外会誌 33 : 1559-1563, 2000
 
30) "抗菌薬使用の手引き" 日本感染症学会/日本化学療法学会編. 協和企画, 2001
 
31) Alica JM, Teresa CH, Michaele LP : Guideline for prevention of surgical site infection, 1999. Inf Cont Hosp Epdermiol 20 : 247-278, 1999
 
32) 炭山嘉伸, 草地信也 : 消化器外科におけるMRSA院内感染とその対策. 日外会誌 93 : 898-901, 1992
 
33) 草地信也, 炭山嘉伸, 長尾二郎, 他 : 術後methicillin-resistant Staphylococcus aureus腸炎の予防対策とその治療-とくにvancomycin経口・経腸投与の有効性について-. 日消外会誌 26 : 1239-1245, 1993
 
34) 陣内傳之助 : "術前術後の管理と合併症". 金原出版 1963, p263-265
 
35) Centers for Disease Control and Prevention. Preventing the spread of vancomycin resistance-report from the hospital infection control practices advisory committee. Federal Register 59 : 25757, 1994
 
36) Hiramatsu K, Aritaka H, Hanaki H, et al : Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin. LANCET 350 : 1670-1673, 1997
 
37) Smith TL, Pearson ML, Wilcox KR, et al : Emergence of vancomycin resistance in Staphylococcus aureus. N Engl J Med 340 : 493-501, 1999
PubMed
38) 花木秀明 : ヘテロVRSAの新規検出法. 化学療法の領域 15 : 575-581, 1999
 
39) O'Sullivan G C : Probiotics. Br J Surg 88 : 161-162, 2001
PubMed
40) de Azavedo JC, Hartigan PJ, de Saxe M, et al : Gram-negative endotoxins and staphylococcal toxic shock syndrome. Prog Clin Biol Res 189 : 419-432, 1985
PubMed
41) Stiles BG, Krakauer T, Bonventre PF : Biological activity of toxic shock syndrome toxin land a site-directed mutant, H135A, in a lipopolysaccharide-potentiated mouse lethality model. Infect Immun 63 : 1229-1234, 1995
 
42) Soltys J, Quinn MT : Modulation of endotoxin- and enterotoxin-induced cytokine release by in vivo treatment with beta- (1, 6) -branched beta- (1, 3) -glucan. Infect Immun 67 : 244-252, 1999
PubMed
43) Dinges MM, Schlievert PM : Comparative analysis of lipopolysaccharide-induced tumor necrosis factor alpha activity in serum and lethality in mice and rabbits pretreated with the staphylococcal superantigen toxic shock syndrome toxin 1. Infect Immun 69 : 7169-7172, 2001
PubMed
44) Beezhold DH, Best GK, Bonventre PF, et al : Endotoxin enhancement of toxic shock syndrome toxin 1-induced secretion of interleukin 1 by murine macrophages. Rev Infect Dis 11 Suppl 1 : S289-293, 1989
 
45) Priest BP, Schlievert PM, Dunn DL : Treatment of toxic shock syndrome with endotoxin-neutralizing antibody. J Surg Res 46 : 527-531, 1989
PubMed
46) Henne E, Campbell WH, Carlson E : Toxic shock syndrome toxin 1 enhances synthesis of endotoxin-induced tumor necrosis factor in mice. Infect Immun 59 : 2929-2933, 1991
PubMed
47) Stiles BG, Campbell YG, Castle RM, et al : Correlation of temperature and toxicity in murine studies of staphylococcal enterotoxins and toxic shock syndrome toxin 1. Infect Immun 67 : 1521, 1999
PubMed
48) 宮本隆司, 木村龍範, . 葉玉哲生, 他 : 開心術後MRSAによると思われるエンドトキシンショックの1例. 臨外会誌 58 : 2264-2266, 1997
 
49) 森脇良太, 勝又健次, 柴田和成, 他 : 高齢者特発性大腸穿孔による敗血症性ショックの1例. Therapeutic Research 19 : 2768-2771, 1998
Medical*Online
50) 中村雅則, 今泉均, 升田好樹, 他 : 高度循環不全を呈したseptic shockに対して, PCPSによる循環補助下に施行したエンドトキシン吸着療法が奏効した1例. エンドトキシン血症治療研究会誌 4 : 14-18, 2000
 
51) 寺西卓也, 岡本良之, 畑憲幸, 他 : MRSAが一次起因菌と思われる有石胆嚢炎に毒素性ショック症候群を合併した1例. 日消誌 99 : 165-169, 2002
Medical*Online
52) 浦英樹, 平田公一, 伝野隆一, 他 : 細菌毒素とその病態. Surgery Frontier 4 : 337-342, 1997
Medical*Online
53) AACP/SCCM Consensus Conference Committee : Definitions for sepsis and organ failure and guidlines for the use of innovative therapies in sepsis. Crit Care Med 20 : 869-871, 1992
 
54) Varga K, Wagner JA, Bridgen DT, et al : Platelet-and macrophage-derived endogenous cannabinoids are involved in endotoxin-induced hypotension. FASEB J 12 : 1035-1044, 1998
PubMed
55) 丸山征郎, 王寅, 劉彦 : エンドトキシン吸着療法 (PMX-DHP) の有効性の機序 (7) : ポリミキシンはアナンダマイドを吸着する. エンドトキシン血症治療研究会誌 4 : 169, 2000
 
56) 川俣知之, 今泉均, 本田亮一, 他 : エンドトキシン吸着が奏功した高TSST-1血症を伴うMRSA敗血症ショックの一例. 集中治療 7 : 631-635, 1995
 
57) 今泉均, 佐藤守仁, 升田好樹, 他 : 敗血症性ショックと血液浄化法 : グラム陽性菌による敗血症性ショックに対するPMX-DHP治療とその有効性の機序-内因性cannabinoidsの関与-. ICUとCCU 25 : S39-41, 2001
 
P.124 掲載の参考文献
1) American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference : Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20 : 864-874, 1992
PubMed
2) Zimmerman JJ : Defining the role of oxyradicals in the pathogenesis of sepsis. Crit Care Med 23 : 616-617, 1995
PubMed
3) Fink MP : Gastrointestinal mucosal injury in experimental models of shock, trauma, and sepsis. Crit Care Med 19 : 627-641, 1991
 
4) Nieuwenhuijen GA, Goris RJ : The gut : the, motor, of multiple organ dysfunction syndrome? Curr Opin Clin Nutr Metab Care 2 : 399-404, 1999
 
5) Maines MD : Heme oxygenase : function, multiplicity, regulatory mechanisms, and clinical applications. FASEB J 2 : 2557-2568, 1988
PubMed
6) Shibahara S : Regulation of heme oxygenase gene expression. Semin Hematol 25 : 370-376, 1988
PubMed
7) Keyse SM, Tyrrell RM : Heme oxygenase is the major 32-kDa stress protein Induced in human skin fibroblasts by UVA radiation, hydrogen, peroxide, and sodium arsenite. Proc Natl Acad Sci USA 86 : 99-103, 1989
PubMed
8) Otterbein LE, Choi AM : Heme oxygenase : colors of defense against cellular stress. Am J Physiol Lung Cell Mol Physiol 279 : L1029-1037, 2000
PubMed
9) Mitani K, Fujita H, Kappas A, et al : Heme oxygenase is a positive acute-phase reactant in human Hep 3 B hepatoma cells. Blood 79 : 1255-1259, 1992
 
10) Stocker R, Yamamoto Y, McDonagh AF, et al : Bilirubin is an antioxidant of possible physiological importance. Science 235 : 1043-1046, 1987
PubMed
11) Otterbein LE, Bach FH, Alam J, et al : Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med 6 : 422-428, 2000
PubMed
12) Brouard S, Otterbein LE, Anrather J, et al : Carbon monoxide generated by heme oxygenase-1 suppresses endothelial cell apoptosis. J Exp Med 192 : 1015-1025, 2000
PubMed
13) 0tterbein LE, Sylvester SL, Choi AM : Hemoglobin provides protection against lethal endotoxemia in rats. Am J Respir Cell Mol Biol 5 : 595-601, 1995
 
14) Poss KD, Tonegawa S : Reduced stress defense in heme oxygenase 1-deficient cells. Proc Natl Acad Sci USA 94 : 10925-10930, 1997
PubMed
15) Shimizu H, Takahashi T, Suzuki T, et al : Protective effect of heme oxygenase induction in ischemic acute renal failure. Crit Care Med 28 : 809-817, 2000
PubMed
16) Toda N, Takahashi T, Mizobuchi S, et al : Tin chloride pretreatment prevents the renal injury in rats with ischemic acute renal failure. Crit Care Med 30 : 1512-1522, 2002
PubMed
17) Suzuki T, Takahashi T, Yamasaki A, et al : Tissue-specific gene expression of heme oxygenase-1 (HO-1) and non-specific deltaaminolevulinate synthase (ALAS-N) in a rat model of septic multiple organ dysfunction syndrome. Biochem Pharmacol 60 : 275-283, 2000
 
18) Huang L, Tan X, Crawford SE, et al : Platelet-activating factor and endotoxin induce tumor necrosis factor gene expression in rat intestine and liver. Immunology 83 : 65-69, 1994
PubMed
19) Adams JK, TepPerman BL : Colonic production and expression of IL-4, IL-6, and IL-10 in neonatal suckling rats after LPS challenge. Am J Physiol Gastrointest Liver Physiol 280 : G755-762, 2001
PubMed
20) Camhi SL, Alam J, Otterbein L, et al : Induction of heme oxygenase-1 gene expression by lipopolysaccharide is mediated by AP-1 activation. Am J Respir Cell Mol Biol 13 : 387-398, 1995
PubMed
21) Otani K, Shimizu S, Chijiiwa K, et al : Administration of bacterial lipopolysaccharide to rats induces heme oxygenase-1 and formation of antioxidant bilirubin in the intestinal mucosa. Dig Dis Sci 45 : 2313-2319, 2000
PubMed
22) Tamaki T, Konoeda Y, Yasuhara M, et al : Glutamine-induced heme oxygenase-1 protects intestines and hearts from warm ischemic injury. Tranasplant Proc 31 : 1018-1019, 1999
PubMed
23) Wang WP, Guo X, Koo MWL, et al : Protective role of heme oxygenase-10n trinitrobenzene sulfonic acid-induced colitis in rat. Am J Physiol Gastrointest Liver Physiol 281 : G 586-594, 2001
 
24) Guo X, Shin VY, Cho CH : Modulation of heme oxygenase in tissue injury and its implication in protection against gastrointestinal diseases. Life Sci 69 : 3113-3119, 2001
PubMed
25) Crouser ED, Julian MW, Weinstein DM, et al : Endotoxin-induced ileal mucosal injury and nitric oxide dysregulation are temporally dissociated. Am J Respir Crit Care Med 161 : 1705-1712, 2000
PubMed

第6章 エンドトキシン血症に対する治療戦略

P.135 掲載の参考文献
1) Wheeler AP, Bernard GRI : Treating patients with severe sepsis. N Engl J Med 340 : 207-214, 1999
 
2) Dinarello CA, Gelfand JA, Wolff SM : Anticytokine strategies in the treatment of the systemic inflammatory response syndrome. JAMA 269 : 1929-1935, 1993
 
3) Medzhitov R, Preston-Hurburt P, Janeway Jr CA : A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388 : 394-397, 1997
 
4) Varga K, Wagner JA, Bridgen T, et al : Platelet- and macrophage-derived endogenous cannabinoids are involved in endotoxin-induced hypotension. FASEB J 12 : 1035-1044, 1998
 
5) Wang H, Bloom O, Zhang M, et al : HMG-1 as a late mediator of endotoxin lethality in mice. Sicence 285 : 248-251, 1999
 
6) Hoffmann JA, Kafatos FC, Janeway CA, et al : Phylogenetic persectives in innate immunity. Science 284 : 1313-1318, 1999
 
7) Takeuchi O, Hoshino K, Kawai T, et al : Differential roles of TLR 2 and TLR 4 in recognition of gram-negative and gram-positive bacterial cell components. Immunity 11 : 443-451, 1999
PubMed
8) Poltorak A, He X, Smirnova I, et al : Defective LPS signaling in C 3 H/HeJ and C 57 BL/ScCr mice : Mutation in TLR 4 gene. Science 282 : 2085-2088, 1998
 
9) Arbour NC, Lorenz E, Schutte BC, et al : TLR 4 mutations are associated with hyporesponsiveness in humans. Nat Genet 25 : 187-191, 2000
 
10) Liu Y, Wang Y, Yamakuchi M, et al : Upregulation of tolHike receptor 2 gene expression in macrophage response to peptidoglycan and high concentration of lipopolysaccharide is involved in NF-κB activation. Infect Immun 69 : 2788-2796, 2001
 
11) Hemmi H, Takeuchi O, Kawai T, et al : A Toll-like receptor recognizes bacterial DNA. Nature 408 : 740-745, 2000
PubMed
12) 審良静夫 : Toll-like receptorによる微生物認識 (Recognition of Microbes by Toll-like receptors). "エンドトキシン研究 4" 日本エンドトキシン研究会編. 医学図書出版, 2001, p 23-32
 
13) 北島勲, 劉彦, 丸山征郎 : Toll-like receptor (TLR) を介する転写因子NF-κB活性化分子機構とアンチセンスNF-κBによるエンドトキシン血症治療法開発. エンドトキシン血症救命治療研究会誌 5 : 173-177, 2001
 
14) 橋本雅仁, 切替富美子, 内記良一, 他 : エンドトキシンショックの治療剤としての抗Toll-like receptor抗体の可能性. "エンドトキシン研究 4" 日本エンドトキシン研究会編. 医学図書出版, 2001, p81-86
 
15) Mansell A, Reinicke A, Worrall DM, et al : The serine protease inhibitor antithrombin III inhibits LPS-mediaited NF-kappaB activation by TLR-4. FEBS Lett 508 : 313-317, 2001
 
16) Porter AC, Sauer JM, Knierman MD, et al : Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor. J pharmacol Experi Thera 301 : 1020-1024, 2002
 
17) Hirst RA, Lambert DG, Notcutt WG : Pharmacology and potential therapeutic uses of cannabis. Brit J Anaesth 81 : 77-84, 1998
PubMed
18) Maccarrone M, De Petrocellis L, Bari M, et al : Lipopolysaccharide downregulates fatty acid amide hydrolase expression and increases anandamide levels in human peripheral lymphocytes. Arch Biochem Biophys 393 : 321-328, 2001
PubMed
19) Liu J, Gao B, Mirshahi F, et al : Functional CB, cannabinoid receptors in human vascular endothelial cells. Biochem J 346 : 835-840, 2000
 
20) Wagner JA, Varga K, Jarai Z, et al : Mesenteric vasodilation mediated by endothelial anandamide receptors. Hypertension 33 : 429-434, 1999
PubMed
21) Zygmunt PM, Petersson J, Andersson DA, et al : Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 400 : 452-457, 1999
PubMed
22) Sarker KP, Obara S, Nakata M, et al : Anandamide induces apoptosis of PC-12 cells : involvement of superoxide and caspase-3. FEBS Lett 472 : 39-44, 2000
PubMed
23) Jarai Z, Wagner JA, Goparaju SK, et al : Cardiovascular effects of 2-arachidonyl glycerol in anesthetized mice. Hypertension 35 : 679-684, 2000
PubMed
24) Klein TW, Lane B, Newton CA, et al : The cannabinoid system and cytokine network. Proc Soc Exp Biol Med 225 : 1-8, 2000
PubMed
25) Craib SJ, Ellington HC, Pertwee RG, et al : A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus. Br J Pharmacol 134 : 30-37, 2001
PubMed
26) Berdyshev E, Boichot E, Corbel M, et al : Effects of cannabinoid receptor ligands on LPS-induced pulmonary inflammation in mice. Life Sci 63 : PL 125-129, 1998
 
27) Izzo AA, Mascolo N, Capasso F : The gastrointestinal pharmacology of cannabinoids. Curr Opin Pharmacol 1 : 597-603, 2001
PubMed
28) Ros J, Claria J, To-Figueras J, et al : Endogenous cannabinoids : a new system involved in the homeostasis of arterial pressure in experimental cirrhosis in the rat. Gastroenterology 122 : 85-93, 2002
PubMed
29) Wang Y, Liu Y, Sarker KP, et al : Polymyxin B binds to anandamide and inhibits its cytotoxic effect. FEBS Lett 470 : 151-155, 2000
 
30) Imaizumi H, Masuda Y, Ezoe E, et al : Absorption of anandamide using polymixin B immobilized fiber improves hemodynamic state in septic patients. Crit Care Med 28 : A142, 2000
 
31) Wang Y, Liu Y, Ito Y, et al : Simultaneous measurement of anandamide and 2- arachidonoylglycerol by polymyxin b-selective adsorption and subsequent high-performance liquid chromatography analysis : increase in endogenous cannabinoids in the sera of patients with endotoxic shock. Anal Biochem 294 : 73-82, 2001
 
32) Imaizumi H, Masuda Y, Ezoe E, et al : Polymixin B immobilized fiber improves hemodynamic state and mortality in MRSA septic patients. Crit Care Med 28 : A172, 2000
 
33) Giuffrida A, Beltramo M, Piomelli D : Mechanisms of endocannabinoid inactivation : biochemistry and pharmacology. J parmacol Experim Ther 298 : 7-14, 2001
 
34) Marino MW, Dunn A, Grail D, et al : Characterization of tumor necrosis factor-deficient mice. Proc Natl Acad Sci USA 94 : 8093-8098, 1997
PubMed
35) Parkkinen J, Raulo E, Merenmies J, et al : Amphoterin, the 30-kDa protein in a family of HMG 1-type polypeptides. Enhanced expression in transformed cells, leading edge localization, and interactions with plasminogen activation. J Bio Chem 268 : 19726-19738, 1993
 
36) Hori O, Brett J, Slattery T, et al : The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system. J Bio Chem 270 : 25752-25761, 1995
 
37) 丸山征郎 : エンドトキシンショックにおけるパラダイムシフトー早期メディエータ : アナンダマイドと後期メディエータ : HMG-1-. 臨床麻酔 24 : 1477-1485, 2000
 
38) Andersson U, Wang H, Palmblad K, et al : High mobility group l protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J Experim Med 192 : 565-570, 2000
 
39) Abraham E, Arcaroli J, Carmody A, et al : HMG-1 as a mediator of acute lung inflammation. J Immun 165 : 2950-2954, 2000
PubMed
40) Wang H, Vishnubhakat JM, Bloom O, et al : Proiflammatory cytokines (tumor necrosis factor and interleukin 1) stimulate release of high mobility group protein-1 by pituicytes. Surgery 126 : 389-392, 1999
 
P.144 掲載の参考文献
1) 池田寿昭, 池田一美, 鬼塚俊朗, 他 : 敗血症性ショック患者に対するPMX-DHPの効果と血管内皮細胞機能. エンドトキシン研究 4. 日本エンドトキシン研究会 編集 窪田達也, 小玉正智, 中野昌康, 医学図書出版株式会社, 2001, p195-200
 
2) Medzhitov R, Preston-Hurlburt P and Janeway C A Jr. : A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388 : 394-397, 1997
PubMed
3) 丸山征郎 : エンドトキシンショックの新展開. エンドトキシン研究 4. 日本エンドトキシン研究会 編集 窪田達也, 小玉正智, 中野昌康, 医学図書出版株式会社, 2001, p33-39
 
4) Wagner JA, Varga K, Jarai Z, et al : Mesenteric vasodilatation mediated by endothelial anandamide receptors. Hypertension 33 : 429-434, 1999
PubMed
5) 今泉均, 佐藤守仁, 升田好樹, 他 : グラム陽性菌による敗血症性ショックに対するPMX-DHP治療とその有効性の機序-内因性cannabinoidsの関与-ICUとCCU 25別冊号 : S 39-41, 2001
 
6) 池田寿昭, 池田一美, 大島一太, 他 : エンドトキシン吸着療法. ICUとCCU 26 : 461-465, 2002
Medical*Online
P.150 掲載の参考文献
1) Morrison DC, Jacobs DM : Binding of polymyxin B to the lipid A portion of bacterial lipopolysaccharides. Immunochemistry 13 : 813-818, 1976
 
2) Srimal S, Surolia N, Balasubramanian S, et al : Titration calorimetric studies to elucidate the specificity of the interactions of polymyxin Bwith lipopolysaccharides and lipid A. Biochem J 315 : 679-686, 1996
 
3) Wang Y, Liu Y, Sarker KP, et al : Polymyxin B binds to anandamide and inhibits its cytotoxic effect. FEBS Letters 470 (2) : 151-155, 2000
 
4) Jacobs DM, Morrison DC : Inhibition of the mitogenic response to lipopolysaccharide (LPS) in mouse spleen cells by polymyxin B. J Immunol 118 : 21-27, 1977
PubMed
5) Aoki H, Kodama M, Tani T, et al : Treatment of sepsis by extracorporeal elimination of endotoxin using polymyxin B-immobilized fiber. Am J Surg 167 : 412-417, 1994
PubMed
6) 今泉均, 佐藤守仁, 升田好樹, 他 : 敗血症性ショックと血液浄化法 : グラム陽性菌による敗血症性ショックに対するPMX-DHP治療とその有効性の機序-内因性cannabinoidsの関与-. ICUとCCU 25 : S39-41, 2001
 
7) Mayumi T, Takezawa J, Takahashi H, et al : Low-dose intramuscular polymyxin B improves survival of septic rats. Shock 11 : 82-86, 1999
PubMed
8) Munster AM, Winchurch RA, Thupari JN, et al : Reversal of postburn immunosuppression with low-dose polymyxin B. J Trauma 26 : 995-998, 1986
PubMed
9) Bender BS, Winchurch RA, Thupari JN, et al : Depressed natural killer cell function in thermally injured adults : successful in vivo and in vitro immunomodulation and the role of endotoxin. Clin Exp Immunol 71 : 120-125, 1988
PubMed
10) Munster AM, Smith MM, Dickerson C, et al : Translocation. Incidental phenomenon or true pathology? Ann Surg 218 : 321-326, 1993
PubMed
11) Endo S, Inada K, Inoue Y, et al : Treatment of endotoxemia with Iow-dose intramuscular injections or oral administration of polymyxin B. Clin Ther 14 : 64-67, 1992
PubMed
12) Endo S, Inada K, Kikuchi M, et al : Clinical effects of intramuscular administration of a small dose of polymyxin B to patients with endotoxemia. Research Comm Chemical Pathol Pharmacol 83 : 223-235, 1994
 
13) 真弓俊彦, 山田浩二郎, 福岡敏雄, 他 : ポリミキシンB少量予防投与の安全性と周術期における効果. 日集中会誌 6 : 229-232, 1999
 
14) American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference : Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20 : 864-874, 1992/Chest 101 : 1644-1655, 1992
 
15) Knaus WA, Draper EA, Wagner DP, et al : APACHE II : a severity of disease classification system. Crit Care Med 13 : 818-829, 1985
PubMed
16) Goris RJ, te BT, Nuytinck JK, et al : Multiple-organ failure. Generalized autodestructive inflammation? Arch Surg 120 : 1109-1115, 1985
 
P.158 掲載の参考文献
1) 星野克明, 審良静男 : 自然免疫系における病原細菌認識機構. 細胞工学 21 : 177-181, 2002
 
2) Kobe B, Deisenfofer J : The leucine-rich repeat : A versatile binding motif. Trends Biochem Sci 19 : 415-421, 1994
 
3) 北島勲 : エンドトキシンの受容体とシグナル伝達. 血液フロンティア 10 : 27-32, 2000
 
4) Medzhitov R, Preston-Hurlburt P, Janeway Jr CA : A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388 : 394-397, 1997
 
5) 松口徹也 : 感染免疫とTLR. 炎症と免疫 9 : 67-76, 2001
 
6) Alexopoulou L, Holt AC, Medzhitov R, et al : Recognition of double-stranded RNA and activation of NF-kB by Toll-like receptor 3. Nature 413 : 732-738, 2001
PubMed
7) Akira S, Takeda K, Kaisho T : TolHike receptors : critical proteins linking innate and acquired immunity. Nature Immunol 2 : 675-680, 2001
 
8) Ulevitch RJ, Tobias PS : Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Ann Rev Immunol 13 : 437-457, 1995
 
9) 北島勲 : エンドトキシンのシグナル伝達. 現代医療 28 : 12-18, 1996
 
10) Hoshino K, Takeuchi O, Kawai T, et al : Cutting edge. TolHike receptor 4 (TLR 4) -deficient mice are hyporesponsive to lipopolysaccharide : evidence for TLR 4 as the Lps gene product. J Immunol 162 : 3749-3752, 1999
 
11) Triantafilou K, Triantafilou M, Dedrick RL : ACD 14-independent LPS receptor cluster. Nat. Immunol 2 : 338-345, 2001
 
12) Takeuchi O, Hoshino K, Kawai H et al : Differential roles of TLR 2 and TLR 4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11 : 443-451, 1999
 
13) Werts C, Tapping RI, Mathison JC, et al : Leptospiral lipopolysaccharide activates cells through a TLR 2-depenent mechanim. Nat Immunol 2 : 346-352, 2001
 
14) Hirschfeld M, Weis JJ, Toshchakov V, et al : Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages. Infect Immun 69 : 1477-1482, 2001
PubMed
15) Mokuno Y, Matsuguchi T, Takano M, et al : Expression of toll-lile receptor 2 on gamma delta T cells bearing invariant V gamma 6/V delta 1 induced by Escherichia coli infection in mice. J Immunol 165 : 931-940, 2000
 
16) Liu Y, Wang Y, Yamakuchi M, et al : Upregulation of Toll-like receptor 2 gene expression in macrophage response to peptidoglycan and high concentration of lipopolysaccharide is involved in NF-κB activation. Infect Immun 69 : 2788-2796, 2001
 
17) Matsuguchi T, Musikacharoen T, Ogawa T, et al : Gene expressions of Toll-like receptor 2, but not Toll-like receptor 4 is induced by and inflammaory cytokines in mouse macrophages. J Immunol 165 : 5767-5772, 2000
PubMed
18) Musikacharoen T, Matsuguchi T, Kikuchi T, et al : NF-kappa B and stat 5 play important roles in the regulation of mouse toll-like receptor 2 gene expression. J Immunol 166 : 4516-4524, 2001
PubMed
19) Faure E, Equilis O, Sieling PA, et al : Bacterial lipopolysacchide activates NF-kappa B through toll-like receptor 4 (TLR 4) in cultured human dermal endothelial cells. Differential expression of TLR-4 and TLR-2 in endohtelial cells. J Biol Chem 275 : 11058-11063, 2000
 
20) Kitaj ima I, Shinohara T, Bilakovics J, et al : Ablation of transplanted HTLV-I tax-transformed tumors in mice by antisense inhibition of NF-κB. Science 258 : 1792-1795, 1992
 
21) Kitajima I : Therapeutic application of antisense oligodeoxynucleotides to inflammation. In"An approach to diseases. Immunology, Hematology, Cancer"Ed Nisho Y, Kyushu University Press, 1996, p 114-127
 
22) 北島勲, 劉彦, 丸山征郎 : Toll like receptor (TLR) を介する転写因子NF-κB活性化分子機構とアンチセンスNF-κBによるエンドトキシン血症治療法開発. エンドトキシン血症治療研究会誌 5 : 173-177, 2001
 

第7章 エンドトキシン血症治療への新展開

P.164 掲載の参考文献
1) Fukata Y, Amano M, Kaibuchi K, et al : Rho-Rho kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells. Trends Pharmacol Sci 22 : 32-39, 2001
PubMed
2) 福原淳範, 入江賢児, 中西宏之, 他 : Rhoファミリー低分子量Gタンパク質による細胞の運動と接着の制御機構. 実験医学 20 : 166-173, 2002
Medical*Online
3) Uehata M, Ishizaki T, Satoh H, et al : Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 389 : 990-994, 1997
PubMed
4) Shimokawa H, Seto M, Katsumata N, et al : Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm. Cardiovasc Res 43 : 1029-1039, 1999
 
5) 鹿取信 : 炎症とプロスタグランジン. 現代医療 27 : 637-684, 1995
 
6) Fujii E, Irie K, Ogawa A, et al : Role of nitric oxide and prostaglandins in Iipopolysaccharide-induced increase in vascular permeability in mouse skin. Eur J Pharmacol 297 : 257-263, 1996
 
7) Wada K, Fujii E, Ishida H, et al : Effect of lipoteichoic acid on dermal vascular permeability in mice. J pharmacol Exp Ther 294 : 280-286, 2000
PubMed
8) Essler M, Staddon JM, Weber PC, et al : Cyclic AMP blocks bacterial lipopolysaccaride-induced myosin light chain phosphorylation in endothelial cells through inhibition on Rho/Rho kinase signaling. J Immunol 164 : 6543-6549, 2000
 
9) Dinarello CA : Immediate cytokine response to endotoxin : Tumor necrosis factor-α and the interleukin-1 family. In "Endotoxin in health and disease" eds Brade H, Opal SM, Vogal SN, et al, Marcel Dekker, New York, 1999, p549-560
 
10) Irie K, Fujii E, Ishida H, et al : Inhibitory effects of cyclic AMP elevating agents on lipopolysaccharide-induced microvascular permeability change in mouse skin. Br J pharmacol 133 : 237-242, 2001
PubMed
11) Shi M, Dennis K, Peschon JJ, et al : Antibodyinduced shedding of CD 44 from adherent cells is linked to the assembly of the cytoskeleton. J Immunol 167 : 123-131, 2001
 
12) Price LS, Norman JC, Ridley AJ, et al : The small GTPases Rac and Rho as regulators of secretion in mast cells. Curr Biol 5 : 68-73, 1995
PubMed
13) Iuvone T, Van Den Bossche R, D'Acquisto F, et al : Evidence that mast cell degranulation, histamine and tumour necrosis factor α release in LPS-induced plasma leakage in rat skin. Br J Pharmacol 128 : 700-704, 1999
 
14) Worthylake RA, Lemoine S, Watson JM, et al : Rho A is required for monocyte tail retraction during migration. J Cell Biol 154 : 147-160, 2001
 
15) Yoshioka R, Matsumura F, Akedo H, et al : Small GTP-binding proten Rho stimulates the actomyosin system, leading to invasion of tumor cells. J Biol Chem 273 : 5146-5154, 1998
 
P.171 掲載の参考文献
1) 中野昌康, 小玉正智編 : エンドトキシン 新しい治療・診断・検査. 講談社サイエンティフィック, 1995, p80
 
2) 比企直樹, 三村芳和, 小川利久, 他 : 外科領域におけるエンドトキシントレランスの応用. エンドトキシン研究 4, 日本エンドトキシン研究会編. 医学図書出版, 2001, p177-183
 
3) Kojima J, Mimura Y, Hiki N, et al : Sympathetic nervous system is related to induction of endotoxin tolerance via beta-adrenergic receptor. J Endotoxin Res 6 : 174, 2000
 
4) Lehner M D, Morath S, Michelsen K S, et al : Induction of cross-Tolerance by lipopolysaccharide and highly purified lipoteichoic acid via different TolHike receptors independent of paracrine mediators. J Immunol 166 : 5161-5167, 2001
PubMed
5) Remi R N, FuYan L, Tejdip S, et al : Endotoxin induces a dose-dependent myocardial cross-tolerance to ischemia-reperfusion injury. Crit Care Med 28 : 1439-1444, 2000
 
6) Nomura F, Akashi S, Sakao Y, et al : Cutting edge : endotoxin tolerance in mouse peritoneal macrophage correlates with down-regulation of surface Toll-like receptor 4 expression. J Immunol 164 : 3476-3479, 2000
PubMed
7) Medvedev A. E, Henneke P, Schromm A, et al : Induction of tolerance to lipopolysaccharide and mycobacterial components in Chinese hamster ovary/CD 14 cells is not affected by overexpression of Toll-like receptors 2 or 4. J Immunol 167 : 2257-2267, 2001
PubMed
8) Carpati C M, Astiz M E, Rackow E C, et al : Monophosphoryl lipid A attenuates the effects of endotoxic shock in pigs. J Lab Clin Med 119 : 346-353, 1992
PubMed
9) Astiz M E, Saha D C, Carpati C M, et al : Induction of endotoxin tolerance with monophosphoryl lipid A in peritonitis : Importance of localized therapy. J Lab Clin Med 123 : 89-93, 1994
PubMed
10) Astiz M E, Rackow E C, Gordon J, et al : Pretreatment of normal humans with monophosphoryl lipid A induces tolerance to endotoxin : A prospective, double-blind, randomized, controlled trial. Crit Care Med 23 : 9-17, 1995
 
11) Salkowski C A, Detore G, Franks A, et al : Pulumonary and hepatic gene expression following cecal ligation and puncture : Monophosphoryl lipid A prophylaxis attenuates sepsis-induced cytokine and chemokine expression and neutrophil infiltration. Infect Immun 66 : 3569-3578, 1998
 
12) Greisman SE, Hornick R B : The nature of endotoxin tolerance. Trans Am Clin Climatol Assoc 86 : 43-50, 1975
PubMed
13) Kertai P, Ujhelyi K, Gerhardt V : Effect of endotoxin pretreatment on surgical lethality in animal experiments. Acta Med Acad Sci Hung 22 : 75-80, 1966
PubMed
14) Rayhane N, Fitting C, Lortholary O, et al : Administration of endotoxin associated with lipopolysaccharide tolerance protects mice against fungal infection. Infect Immun 68 : 3748-3753, 2000
PubMed
15) Kox W J, Volk T, Kox S N, et al : Immunomodulatory therapies in sepsis. Intensive Care Medicine 26 : S124-128, 2000
PubMed
16) Wolk K, Docke WD, von Baehr V, et al : Impaired antigen presentation by human monocytes during endotoxin tolerance. Blood 96 : 218-223, 2000
PubMed
17) Jean-Marc Cavaillon : The nonspecific nature of endotoxin tolerance. Trends in microbiology 3 : 320-324, 1995
 
18) West MA, Heagy W : Endotoxin tolerance : A review. Crit Care Med 30 : S64-73, 2002
 
19) Heagy W, Hansen C, Nieman K, et al : impaired ex vivo lipopolysaccharide-stimulated whole blood tumor necrosis factor production may identify "septic" intensive care unit patients. Shock 14 : 271-276, 2000
PubMed
20) Ismaili J, Rennesson J, Aksoy E, et al : Monophosphoryl lipid A activates both human dendritic cells and T cells. J Immunol 168 : 926-932, 2002
 
21) Saha D C, Barua R S, Astiz M E, et al : Monophosphoryl lipid A stimulated up-regulation of reactive oxygen intermediates in human monocytes in vitro. J Leukoc Biol 70 : 381-385, 2001
PubMed
22) Wang H, Bloom O, Zhang M, et al : HMG-1 as a late mediator of endotoxin lethality in mice. Science 285 : 248-251, 1999
PubMed
P.179 掲載の参考文献
1) Cavaillon JM. The nonspecific nature of endotoxin tolerance. Trends in Microbiol 3 : 320-324, 1995
PubMed
2) He W, Fong Y, Marano MA, et al : Tolerance to endotoxin prevents mortality in infected thermal injury : association with attenuated cytokine responses. J Infect Dis 165 : 859-864, 1992
PubMed
3) Barroso-Aranda J, Chavez-Chavez RH, Mathison JC, et al : Circulating neutrophil kinetics during tolerance in hemorrhagic shock using bacterial lipopolysaccharide. Am J Physiol 266 : H415-421, 1994
PubMed
4) Baker CH, Sutton ET, Price JM : Arteriolar reactivity of endotoxin-tolerant rats after hemorrhage and reinfusion. Shock 4 : 455-460, 1995
PubMed
5) Kawabata A, Hata T, Kuroda R : Cross tolerance to environmental stress and endotoxin. Life Sciences 62 : PL 327-333, 1998
 
6) Hiki N, Mimura Y, Kojima J, et al : Endotoxin evokes superresistance to rat systemic hypoxia. FASEB J 14 : A573, 2000
 
7) Zuckerman SH, Evans GF, Butler LD : Endotoxin tolerance : Independent of interleukin-1 and tumor necrosis factor expression. Infect Immun 59 : 2774-2780, 1991
PubMed
8) Ayala A, Kisala JM, Felt JA : Does endotoxin tolerance prevent the release of inflammatory monokines (interleukin 1, interluekin 6, or tumor necrosis factor) during sepsis? Arch Surg 127 : 191-197, 1992
PubMed
9) Zuckerman SH, Evans GF : Endotoxin tolerance : In vivo regulation of tumor necrosis factor and interluekin-1 synthesis ia at the trancriptional level. Cell Immunol 140 : 513-519, 1992
 
10) Freudenberg MA, Galanus C : Induction of tolerance to lipopolysaccharide (LPS) -Dgalactosamine lethality by pretreatment with LPS is mediated by macrophages. Infect Immun. 56 : 1352-1357, 1988
PubMed
11) Egawa K, Yoshida M, Sakaino R, et al : Hepatic drug-metabolizing enzyme system and endotoxin tolerance : structural requirement of LPS in induction of an early tolerance. Microbiol Immunol 28 : 1181-1190, 1984
PubMed
12) Munoz C, Carlet J, Fitting C, et al : Dysregulation of in vitro cytokine production by monocytes during sepsis. J CIin Invest 88 : 1747-1754, 1991
 
13) van Deuren M, van der Ven-Jongekrijg J, Demacker PN, et al : Differential expression of proinflammatory cytokines and their inhibitiors during the course of meningococcal infections. J Infect Dis 169 : 157-161, 1994
 
14) Marchant A, Alegre ML, Hakim A, et al : Clinical and Biological significance of interleukin-10 plasma levels in patients with septic shock. J Clin Immunol 15 : 265-272, 1995
 
15) Cabie A, Fitting C, Farkas JC, et al : Influence of surgery on in-vitro cytokine production by human monocytes. Cytokine 4 : 576-580, 1992
PubMed
16) Kleinschmidt S, Wanner GA, Bussmann D, et al : Proinflammatory cytokine gene expression in whole blood from patients undergoing coronary artery bypass surgery and its modulation by pentoxifylline. Shock 9 : 12-20, 1998
PubMed
17) Faist E, Mewes A, Strasser T, et al : Alteration of monocyte function following major injury. Arch Surg 123 : 287-292, 1998
 
18) Mackensen A, Galanos C, Engelhardt R : Modulating activity of interferon-gamma on endotoxin-induced cytokine production in cancer patient. Blood 78 : 3254-3258, 1991
PubMed
19) Ogawa M : Systemic inflammatory response syndrome : a concept of avoiding organ dysfunction induced by a "second attack". Surg Today 28 : 679-681, 1998
PubMed
20) Traves DC, Long J, Daniel PR, et al : Preexposure of murine macrophage to CpG oligonucleotide results in a biphasic tumor necrosis factor alpha response to subsequent lipopolysaccharide challenge. Infect Immun 69 : 2123-2129, 2001
 
21) Coffee KA, Halushka PV, Ashton SH, et al : Endotoxin tolerance is associated with altered GTP-binding protein function. Am J Physiol 73 : 1008-1013, 1992
 
22) James K, Laurel C, Jorge LR, et al : Macrophage TNF secretion in endotoxin tolerance : Role of SAPK, p 38, and MARK. J surg res 83 : 158-164, 1999
 
23) Adib-Conquy M, Adrie C, Moine P, et al : NF-kappaB expression in mononuclear cells of patients with sepsis resembles that obserbrf in Iipopolysaccharide tolerance. Am J Respir Crit Care Med 162 : 1877-1883, 2000
 
24) Sato S, Nomura F, Akira S, et al : Synergy and cross-tolerance between toll-like receptor (TLR) 2-and TLR 4-mediated signaling pathway. J immunol 165 : 7096-7101, 2000
PubMed
25) West MA, Heagy W : Endotoxin tolerance : A review. Crit Care Med 30 : 64-73, 2002
 
P.187 掲載の参考文献
1) Berg RD, Garlington AW : Translocation of certain indigenous bacteria from the gastrointestinal tract to the mesenteric lymph nodes and other organs in a gnotobiotic mouse model. Infect Immun 23 : 403-411, 1979
 
2) Fink MP : Gastrointestinal mucosal injury in experimental models of shock, trauma, and sepsis. Crit Care Med 19 : 627-641, 1991
 
3) Martin C, Thomachot L, Quinio B, et al : Comparing two heat and moisture exchangers with one vaporizing humidifier in patients with minute ventilation greater than 10 L/min. Chest 107 : 1411-1415, 1995
PubMed
4) Uinio B, Albanese J, Bues-Charbit M, et al : Selective decontamination of the digestive tract in multiple trauma patients. A prospective double-blind, randomized, placebocontrolled study. Chest 109 : 765-772, 1996
PubMed
5) Alverdy J, Piano G : Whole gut washout for severe sepsis : review of technique and preliminary results. Surgery 121 : 89-94, 1997
PubMed
6) 辻本広紀, 小野聡, 山内明, 他 : 腸管粘膜のbacterial translocationとその分子医学的診断法 (PCR). "臨床消化器内科" 玉熊正悦編. 日本メディカルセンター, 2001, p891-898
 
7) 木下学, 吉村一克, 望月英隆, 他 : TPN施行時のグルタミン補充に関する実験的, 臨床的検討-腸粘膜萎縮および腸管壁translocation抑制効果を中心に-. 外科と代謝・栄養 25 : 190-197, 1991
 
8) Palacio JC, Rombeau JL : Dietary fiber : a brief review and potential application to enteral nutrition. Nutr Clin Pract 5 : 99-106, 1990
PubMed
9) 金森豊, 橋都浩平, 諸富正己, 他 : 重症小児外科疾患患児の腸内細菌叢異常と, probiotics・prebiotics併用療法による腸内細菌叢のコントロール・腸管機能改善効果について. 外科と代謝・栄養 34 : 49-58, 2000
 

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