分子栄養学概論

出版社： 建帛社
著者：
発行日： 1996-04-25
分野： 臨床医学：一般  >  栄養/食事/輸血
ISBN： 9784767960661
電子書籍版： 1996-04-25 （初版）
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目次

  • 表紙
  • 序文
  • 目次
  • 序章 分子栄養学の展開
  • 1. はじめに
  • 2. 分子栄養学への道程
  • 3. 分子栄養学という分野
  • 4. おわりに
  • 第1章 遺伝子発現制御の研究方法論
  • 1. はじめに
  • 2. 遺伝子発現過程における可能な制御段階とその検証方法
  • 3. 転写制御領域と転写因子の同定・解析法
  • 〔糖代謝〕
  • 第2章 糖の膜透過の制御とその異常
  • 1. はじめに
  • 2. Na-糖共輸送担体 (SGLT)
  • 3. 促通拡散型糖輸送担体 (GLUT)
  • 4. 腫瘍と糖輸送担体
  • 5. 糖尿病と糖輸送担体
  • 6. 糖輸送担体異常症
  • 7. おわりに
  • 第3章 解糖系の制御
  • 1. はじめに
  • 2. PKの遺伝子構造
  • 3. 正常および糖尿病ラットでのL型PK遺伝子発現の制御
  • 4. 初代培養肝細胞でのL型PK遺伝子の発現制御
  • 5. L型PK遺伝子の発現制御領域
  • 6. L型PK遺伝子の炭水化物による転写制御に関与する代謝産物
  • 7. L型PK遺伝子のCarRUに作用する転写因子
  • 8. 他の解糖系酵素の遺伝子発現制御
  • 〔脂質代謝〕
  • 第4章 脂肪酸合成の制御
  • 1. はじめに
  • 2. 遺伝子発現の経時変化
  • 3. 食餌量の影響
  • 4. 食餌栄養素の影響
  • 5. 多価不飽和脂肪酸とインスリン受容体
  • 6. インスリンによる調節
  • 7. 解糖系酵素との関連
  • 8. 遺伝子レベルでの解析
  • 9. おわりに
  • 第5章 コレステロール代謝および血清リポタンパク代謝
  • 1. はじめに
  • 2. リポタンパク代謝関連遺伝子
  • 3. リポタンパク代謝とその調節因子
  • 4. コレステロール代謝とその調節
  • 〔タンパク質代謝〕
  • 第6章 タンパク質代謝とIGF-I
  • 1. タンパク質栄養とホルモン
  • 2. IGF-I
  • 3. IGFBP
  • 4. IGFレセプター
  • 5. IGF-Iに応答した細胞内の信号伝達
  • 6. IGF-Iと他のホルモンとのクロストーク
  • 7. 成長におけるIGF-IおよびIGFBPの意義
  • 8. タンパク質栄養とIGF-I
  • 9. IGF-IおよびIGFBP遺伝子の発現制御の機構
  • 10. タンパク質栄養によるタンパク質の合成・分解調節
  • 11. おわりに
  • 第7章 酵素タンパク質代謝制御 ―特にオルニチン脱炭酸酵素の分解調節機序
  • 1. はじめに
  • 2. ODCの純化と性状解析
  • 3. ポリアミンによるODC分解制御とアンチザイムの役割
  • 4. ODC分解制御の分子機序
  • 5. その他の展開と今後の展望
  • 6. おわりに
  • 第8章 タンパク質合成とポリソーム形成
  • 1. 体タンパク質合成とポリソーム形成
  • 2. タンパク質栄養状態によるポリソームパターンの変化
  • 3. ポリソームパターンによる食品タンパク質の栄養評価
  • 4. タンパク質必要量とポリソームパターン
  • 5. おわりに
  • 〔ビタミン〕
  • 第9章 非環式レチノイドによる分化・増殖制御
  • 1. はじめに
  • 2. レチノイドとしてのポリプレン酸
  • 3. 非環式レチノイドの生物作用
  • 4. 非環式レチノイドの非レチノイド作用
  • 5. イソプレノイドとしての非環式レチノイド
  • 6. 発がん抑制におけるアポトーシスの役割とイソプレノイド
  • 7. おわりに
  • 第10章 ビミタンA代謝と遺伝子発現調節
  • 1. はじめに
  • 2. 生体内ビタミンA転送と生理機能の概略
  • 3. 核内レチノイン酸受容体
  • 4. 核内レチノイン酸受容体の構造と機能
  • 5. 核内受容体の応答配列と結合様式
  • 6. ビタミンA栄養と遺伝子発現
  • 7. おわりに
  • 第11章 ビタミンDの生理作用
  • 1. ビタミンDの作用
  • 2. 活性型ビタミンD
  • 3. ビタミンD受容体
  • 4. ビタミンD応答配列
  • 5. ビタミンDと疾患
  • 6. おわりに
  • 〔代謝異常と分子栄養学〕
  • 第12章 生体異物と遺伝子発現
  • 1. はじめに
  • 2. 芳香族炭化水素誘導型チトクローム P-450
  • 3. フェノバルビタール誘導型チトクローム P-450
  • 4. 薬物代謝第2相酵素群の誘導
  • 5. 生体異物による脂質代謝変動
  • 第13章 肥満の分子栄養学
  • 1. はじめに
  • 2. 肥満の疫学
  • 3. 食欲調節の分子機構
  • 4. エネルギー消費の異常
  • 5. 肥満におけるインスリン抵抗性
  • 索引
  • 奥付

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第1章 遺伝子発現制御の研究方法論

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〔糖代謝〕

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〔脂質代謝〕

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〔代謝異常と分子栄養学〕

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