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> TFOD and TFOT Expert Lecture　Paradigm Shift in the Clinical Practice for Dry Eye

TFOD and TFOT Expert Lecture　Paradigm Shift in the Clinical Practice for Dry Eye

出版社：	メディカルレビュー社
著者：	横井則彦(著)
発行日：	2020-03-31
分野：	臨床医学：外科 > 眼科学
ISBN：	9784779223587
電子書籍版：	2020-03-31 （初版第1刷）

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TFOD・TFOTのコンセプトを理解し、診療に役立てていただくための分かりやすい解説
TFOD・TFOTの基本的な考え方や、実際の症例においてどのポイントを重視すればよいのかなど、読者に寄り添い分かりやすく解説いたします。
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目次

１．Concept of Dry Eye
２．Tear Meniscus and Tear Dynamics
３．Structure and Function of the Ocular Surface
４．Components of the Ocular Surface and Their Functions
５．Dynamics of Tear Film Layer Associated with Eye Opening
６．Concept of TFOD for TFOT
７．Tear Film Breakup Pattern（BUP）Classification for TFOD
８．Summary of TFOD and TFOT and Associated Advantages
９．Effective Staining and Blinking Methods for TFOD
１０．Actual Eye-Drop Treatment Practices
１１．After Becoming a TFOD Expert

この書籍の参考文献

参考文献のリンクは、リンク先の都合等により正しく表示されない場合がありますので、あらかじめご了承下さい。

本参考文献は電子書籍掲載内容を元にしております。

1 Concept of Dry Eye

P.9 掲載の参考文献

1) Shimazaki J, Yokoi N, Watanabe H, et al. Definition and diagnosis of dry eye in Japan, 2016 [in Japanese]. Atarashii Ganka (J Eye). 2017 ; 34 : 309-13.

2) Tsubota K, Yokoi N, Shimazaki J, et al : New Perspectives on Dry Eye Definition and Diagnosis : A Consensus Report by the Asia Dry Eye Society. Ocul Surf. 2017 ; 15 : 65-76.

3) Yokoi N, Georgiev GA : Tear Film-Oriented Diagnosis and Tear Film-Oriented Therapy for Dry Eye Based on Tear Film Dynamics. Invest Ophthalmol Vis Sci. 2018 ; 59 : DES13-DES22.

4) Toda I, Shimazaki J, Tsubota K : Dry eye with only decreased tear break-up time is sometimes associated with allergic conjunctivitis. Ophthalmology. 1995 ; 102 : 302-9.

5) Shimazaki J ; Japanese Dry Eye Society. Definition and diagnosis of dry eye 2006 [in Japanese]. Atarashii Ganka (J Eye). 2007 ; 24 : 181-4.

6) Yokoi N, Uchino M, Uchino Y, et al : Importance of tear film instability in dry eye disease in office workers using visual display terminals : the Osaka study. Am J Ophthalmol. 2015 ; 159 : 748-54.

7) No authors listed : The epidemiology of dry eye disease : report of the Epidemiology Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf. 2007 ; 5 : 93-107.

8) Toda I, Fujishima H, Tsubota K : Ocular fatigue is the major symptom of dry eye.Acta Ophthalmol (Copenh). 1993 ; 71 : 347-52.

9) Yokoi N, Georgiev GA, Kato H, et al : Classification of fluorescein breakup patterns : A novel method of differential diagnosis for dry eye. Am J Ophthalmol. 2017 180.

3 Structure and Function of the Ocular Surface

P.14 掲載の参考文献

1) Holly FJ. Physical chemistry of the normal and disordered tear film. Trans Ophthalmol Soc UK. 1985 ; 104 : 374-80.

2) McDonald JE, Brubaker S. Meniscus-induced tear film thinning. Am J Ophthalmol. 1971 ; 1 : 139-46.

3) Kakizaki H, Zako M, Miyaishi O, et al. The lacrimal canaliculus and sac bordered by the Horner's muscle form the functional lacrimal drainage system. Ophthalmology. 2005 ; 112 : 710-6.

4) Creech JL, Do LT, Fatt I, et al. In vivo tear-film thickness determination and implications for tear-film stability. Curr Eye Res. 1998 ; 17 : 1058-66.

5) King-Smith PE, Fink BA, Hill RM, et al. The thickness of the tear film. Curr Eye Res. 2004 ; 29 : 357-68.

6) Yokoi N, Takehisa Y, Kinoshita S. Correlation of tear lipid layer interference patterns with the diagnosis and severity of dry eye. Am J Ophthalmol. 1996 ; 122 : 818-24.

7) Ho RW, Fang PC, Chao TL, et al. Increase lipid tear thickness after botulinum neurotoxin A injection in patients with blepharospasm and hemifacial spasm. Sci Rep. 2018 ; 8 : 8367.

8) Hosotani Y, Yokoi N, Okamoto M, et al. Characteristics of tear abnormalities associated with benign essential blepharospasm and amelioration by means of botulinum toxin type A treatment. Jpn J Ophthalmol. 2020 ; 64 : 45-53.

9) Miller KL, Polse KA, Radke CJ. Black-line formation and the "perched" human tear film. Curr Eye Res. 2002 ; 25 : 155-62.

10) Yokoi N, Bron AJ, Georgiev GA. The precorneal tear film as a fluid shell : the effect of blinking and saccades on tear film distribution and dynamics. Ocul Surf. 2014 ; 12 : 252-66.

11) Kwok SK, Tse DT. Central corneal dellen : a complication of upper eyelid tarsotomy. Ophthalmic Plast Reconstr Surg. 2000 ; 16 : 237-40.

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4 Components of the Ocular Surface and Their Functions

P.15 掲載の参考文献

1) Lam SM, Tong L, Duan X, Petznick A, Wenk MR, Shui G : Extensive characterization of human tear fluid collected using different techniques unravels the presence of novel lipid amphiphiles. J Lipid Res. 2014 ; 55 : 289-98.

2) Yokoi N, Bron AJ, Georgiev GA : The precorneal tear film as a fluid shell : the effect of blinking and saccades on tear film distribution and dynamics. Ocul Surf. 2014 ; 12 : 252-66.

3) Wolff E : The muco-cutaneous junction of the lid margin and the distribution of the tear fluid. Trans. Ophthalmol. Soc. UK. 1946 ; 66 : 291-308.

5 Dynamics of Tear Film Layer Associated with Eye Opening

P.19 掲載の参考文献

1) Lam SM, Tong L, Duan X, et al. Extensive characterization of human tear fluid collected using different techniques unravels the presence of novel lipid amphiphiles. J Lipid Res. 2014 ; 55 : 289-98.

2) Bron AJ, Tiffany JM, Gouveia SM, et al. Functional aspects of the tear film lipid layer. Exp Eye Res. 2004 ; 78 : 347-60.

3) Mishima S, Maurice DM. The oily layer of the tear film and evaporation from the corneal surface. Exp Eye Res. 1961 ; 1 : 39-45.

4) Yokoi N, Yamada H, Mizukusa Y, et al. Rheology of tear film lipid layer spread in normal and aqueous tear-deficient dry eyes. Invest Ophthalmol Vis Sci. 2008 ; 49 : 5319-24.

5) Georgiev GA, Yokoi N, Ivanova S, et al. Surface relaxations as a tool to distinguish the dynamic interfacial properties of films formed by normal and diseased meibomian lipids. Soft Matter. 2014 ; 14 : 5579-88.

6) Cerretani CF, Ho NH. Radke CJ. Water-evaporation reduction by duplex films : application to the human tear film. Adv Colloid Interface Sci. 2013 ; 197-8 : 33-57.

7) Eftimov P, Yokoi N, Tonchev V, et al. Surface properties and exponential stress relaxations of mammalian meibum films. Eur Biophys J. 2017 ; 46 : 129-40.

8) Georgiev GA, Eftimov P, Yokoi N. Structure-function relationship of tear film lipid layer : A contemporary perspective. Exp Eye Res. 2017 ; 163 : 17-28.

9) Bhamla MS, Chai C, Rabiah NI, et al. Instability and breakup of model tear films. Invest Ophthalmol Vis Sci. 2016 ; 57 : 949-58.

10) Yokoi N, Bron AJ, Georgiev GA. The precorneal tear film as a fluid shell : the effect of blinking and saccades on tear film distribution and dynamics. Ocul Surf. 2014 ; 12 : 252-66.

11) Tiffany JM. Measurement of wettability of the corneal epithelium. II. Contact angle method. Acta Ophthalmol (Copenh). 1990 ; 68 : 182-7.

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13) Fatt I. Observations of tear film break up on model eyes. CLAO J. 1991 ; 17 : 267-81.

14) Versura P, Maltarello MC, Caramazza R, et al. Mucus alteration and eye dryness. A possible relationship. Acta Ophthalmol (Copenh). 1989 ; 67 : 455-64.

15) Georgiev GA, Yokoi N, Ivanova S, et al. Surface chemistry study of the interactions of hyaluronic acid and benzalkonium chloride with meibomian and corneal cell lipids. Soft Matter. 2013 ; 9 : 10841-56.

16) Kessing SV. Mucous gland system of the conjunctiva. A quantitative normal anatomical study. Acta Ophthalmol (Copenh). 1968 : Suppl 95 : 1+.

17) Knop N, Korb DR, Blackie CA, et al. The lid wiper contains goblet cells and goblet cell crypts for ocular surface lubrication during the blink. Cornea. 2012 ; 31 : 668-79.

18) Korb DR, Greiner JV, Herman JP, et al. Lid-wiper epitheliopathy and dry-eye symptoms in contact lens wearers. CLAO J. 2002 ; 28 : 211-6.

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20) Gipson IK. Distribution of mucins at the ocular surface. Exp Eye Res. 2004 ; 78 : 379-88.

21) Ablamowicz AF, Nichols JJ. Ocular surface membrane-associated mucins. Ocul Surf. 2016 ; 14 : 331-41.

22) King-Smith PE, Fink BA, Hill RM, et al. The thickness of the tear film. Curr Eye Res. 2004 ; 29 : 357-68.

23) Georgiev GA, Eftimov P, Yokoi N. Contribution of Mucins towards the Physical Properties of the Tear Film : A Modern Update. Int J Mol Sci. 2019 ; 20 : pii : E6132.

24) Argueso P, Guzman-Aranguez A, Mantelli F, et al. Association of cell surface mucins with galectin-3 contributes to the ocular surface epithelial barrier. J Biol Chem. 2009 ; 284 : 23037-45.

25) Nichols BA, Chiappino ML, Dawson CR. Demonstration of the mucous layer of the tear film by electron microscopy. Invest Ophthalmol Vis Sci. 1985 ; 26 : 464-73.

P.22 掲載の参考文献

1) King-Smith PE, Fink BA, Hill RM, et al. The thickness of the tear film. Curr Eye Res. 2004 ; 29 : 357-68.

2) Yokoi N, Bron AJ, Georgiev GA. The precorneal tear film as a fluid shell : the effect of blinking and saccades on tear film distribution and dynamics. Ocul Surf. 2014 ; 12 : 252-66.

3) Yokoi N, Georgiev GA. Tear-film-oriented diagnosis and therapy for dry eye. In : Yokoi N, editor. Dry Eye Syndrome : Basic and Clinical Perspectives. London : Future Medicine ; 2013. p96-108.

4) Yokoi N, Georgiev GA, Kato H, et al. Classification of fluorescein breakup patterns : A novel method of differential diagnosis for dry eye. Am J Ophthalmol. 2017 ; 180 : 72-85.

5) Yokoi N, Georgiev GA. Tear Film-Oriented Diagnosis and Tear Film-Oriented Therapy for Dry Eye Based on Tear Film Dynamics. Invest Ophthalmol Vis Sci. 2018 ; 59 : DES13-DES22.

6) Yokoi N, Georgiev GA. Tear-film-oriented diagnosis for dry eye. Jpn J Ophthalmol. 2019 ; 63 : 127-36.

7) McDonald JE, Brubaker S. Meniscus-induced tear film thinning. Am J Ophthalmol. 1971 ; 72 : 139-46.

8) Koh S, Tung CI, Inoue Y, et al. Effects of tear film dynamics on quality of vision. Br J Ophthalmol. 2018 ; 102 : 1615-20.

9) Yokoi N, Yamada H, Mizukusa Y, et al. Rheology of tear film lipid layer spread in normal and aqueous tear-deficient dry eyes. Invest Ophthalmol Vis Sci. 2008 ; 49 : 5319-24.

10) Yokoi N, Takehisa Y, Kinoshita S. Correlation of tear lipid layer interference patterns with the diagnosis and severity of dry eye. Am J Ophthalmol. 1996 ; 122 : 818-24.

P.34 掲載の参考文献

1) Yokoi N, Georgiev GA. Tear-film-oriented diagnosis and therapy for dry eye. Dry Eye Syndrome : Basic and Clinical Perspectives. London : Future Medicine. 2013 ; 96-108.

2) Yokoi N, Georgiev GA, Kato H, et al. Classification of fluorescein breakup patterns : A novel method of differential diagnosis for dry eye. Am J Ophthalmol. 2017 ; 180 : 72-85.

3) Yokoi N, Georgiev GA. Tear Film-Oriented Diagnosis and Tear Film-Oriented Therapy for Dry Eye Based on Tear Film Dynamics. Invest Ophthalmol Vis Sci. 2018 ; 59 : DES13-DES22.

4) Yokoi N, Georgiev GA. Tear-film-oriented diagnosis for dry eye. Jpn J Ophthalmol. 2019 ; 63 : 127-36.

5) Freeman JM. The punctum plug : Evaluation of a new treatment of dry eye. Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol. 1975 ; 79 : OP874-9.

6) Kojima K, Yokoi N, Nakamura Y, et al. Outcome of punctal plug occlusion therapy for severe dry eye syndrome [in Japanese]. Nippon Ganka Gakkai Zasshi (J Jpn Ophthalmol Soc). 2002 ; 106 : 360-4.

7) Takaoka-Shichijo Y, Nakamura N. Stimulatory effect of diquafosol tetrasodium in the expression of membrane-binding mucin genes in cultured human corneal epithelial cells [in Japanese]. Atarashii Ganka (J Eye). 2011 ; 28 : 425-9.

8) Georgiev GA, Eftimov P, Yokoi N. Contribution of Mucins towards the Physical Properties of the Tear Film : A Modern Update. Int J Mol Sci. 2019 ; 20 : pii : E6132.

9) Takeji Y, Urashima H, Aoki A, et al. Rebamipide increases the mucin-like glycoprotein production in corneal epithelial cells. J Ocul Pharmacol Ther. 2012 ; 28 : 259-63.

10) Uchino Y, Woodward AM, Argueso P. Differential effect of rebamipide on transmembrane mucin biosynthesis in stratified ocular surface epithelial cells. Exp Eye Res. 2016 ; 153 : 1-7.

11) Ablamowicz AF, Nichols JJ. Ocular Surface Membrane-Associated Mucins. Ocul Surf. 2016 ; 14 : 331-41.

12) Blalock TD, Spurr-Michaud SJ, Tisdale AS, et al. Release of membrane-associated mucins from ocular surface epithelia. Invest Ophthalmol Vis Sci. 2008 ; 49 : 1864-71.

13) Yokoi N, Kato H, Kinoshita S. Facilitation of tear fluid secretion by 3% diquafosol ophthalmic solution in normal human eyes. Am J Ophthalmol. 2014 ; 157 : 85-92.

14) Yokoi N, Kato H, Kinoshita S. The increase of aqueous tear volume by diquafosol sodium in dry-eye patients with Sjogren's syndrome : a pilot study. Eye (Lond). 2016 ; 30 : 857-64.

15) Takamura E, Tsubota K, Watanabe H, et al. Diquafosol Ophthalmic Solution Phase 3 Study Group. A randomised, double-masked comparison study of diquafosol versus sodium hyaluronate ophthalmic solutions in dry eye patients. Br J Ophthalmol. 2012 ; 96 : 1310-5.

16) Aoki T, Yokoi N, Kato H, et al. Mechanism and current state of treatment for filamentary keratitis with dry eye [in Japanese]. Nippon Ganka Gakkai Zasshi (J Jpn Ophthalmol Soc). 2019 ; 123 : 1065-70.

17) Berger RE, Corrsin S. A surface tension gradient mechanism for driving the pre-corneal tear film after a blink. J Biomech. 1974 ; 7 : 225-38.

18) King-Smith PE, Reuter KS, Braun RJ, et al. Tear film breakup and structure studied by simultaneous video recording of fluorescence and tear film lipid layer images. Invest Ophthal Vis Sci. 2013 ; 54 : 4900-9.

19) Bull JL, Grotberg JB. Surfactant spreading on thin viscous films : film thickness evolution and periodic wall stretch. Exp Fluids. 2003 ; 34 : 1-15.

20) Zhang YL, Matar OK, Craster RV. Analysis of tear film rupture : effect of non-Newtonian rheology. J Colloid Interface Sci. 2003 ; 262 : 130-48.

21) Yokoi N, Yamada H, Mizukusa Y, et al. Rheology of tear film lipid layer spread in normal and aqueous tear-deficient dry eyes. Invest Ophthalmol Vis Sci. 2008 ; 49 : 5319-24.

22) Georgiev GA, Yokoi N, Ivanova S, et al. Surface relaxations as a tool to distinguish the dynamic interfacial properties of films formed by normal and diseased meibomian lipids. Soft Matter. 2014 ; 14 : 5579-88.

23) Eftimov P, Yokoi N, Tonchev V, et al. Surface properties and exponential stress relaxations of mammalian meibum films. Eur Biophys J. 2017 ; 46 : 129-40.

24) Georgiev GA, Eftimov P, Yokoi N. Structure-function relationship of tear film lipid layer : A contemporary perspective. Exp Eye Res. 2017 ; 163 : 17-28.

25) Shigeyasu C, Hirano S, Akune Y, et al. Diquafosol tetrasodium increases the concentration of mucin-like substances in tears of healthy human subjects. Curr Eye Res. 2015 ; 40 : 878-83.

26) Rendon C, Brochard-Wyart F, Rondelez F. Dynamics of dewetting. Physical Review Letters. 1991 ; 66 : 715-9.

9 Effective Staining and Blinking Methods for TFOD

P.37 掲載の参考文献

1) Yokoi N, Georgiev GA. Tear Film-Oriented Diagnosis and Tear Film-Oriented Therapy for Dry Eye Based on Tear Film Dynamics. Invest Ophthalmol Vis Sci. 2018 ; 59 : DES13-DES22.

2) Tsubota K, Yokoi N, Watanabe H, et al. A New Perspective on Dry Eye Classification : Proposal by the Asia Dry Eye Society. Eye Contact Lens. 2020 ; 46 Suppl 1 : S2-S13.

11 After Becoming a TFOD Expert

P.40 掲載の参考文献

1) Yokoi N, Georgiev GA. Tear Film-Oriented Diagnosis and Tear Film-Oriented Therapy for Dry Eye Based on Tear Film Dynamics. Invest Ophthalmol Vis Sci. 2018 ; 59 : DES13-DES22.

2) Yokoi N, Komuro A, Nishii M, et al. Clinical impact of conjunctivochalasis on the ocular surface. Cornea. 2005 ; 24 : S24-S31.

3) Mimura T, Yamagami S, Usui T, et al. Changes of conjunctivochalasis with age in a hospital-based study. Am J Ophthalmol. 2009 ; 147 : 171-7.

4) Yokoi N, Komuro A, Maruyama K, et al. New surgical treatment for superior limbic keratoconjunctivitis and its association with conjunctivochalasis. Am J Ophthalmol. 2003 ; 135 : 303-8.

5) Korb DR, Herman JP, Greiner JV, et al. Lid wiper epitheliopathy and dry eye symptoms. Eye Contact Lens. 2005 ; 31 : 2-8.

6) Tanioka H, Yokoi N, Komuro A, et al. Investigation of the corneal filament in filamentary keratitis. Invest Ophthalmol Vis Sci. 2009 ; 50 : 3696-702.

7) Ikegawa W, Yamaguchi M, Shiraishi A et al. Efficacy of rebamipide ophthalmic solution for treatment-resistant filamentary keratitis : Three case reports [in Japanese]. Atarashii Ganka (J Eye). 2014 ; 31 : 1369-73.

8) Itakura H, Kashima T, Itakura M, et al. Topical rebamipide improves lid wiper epitheliopathy. Clin Ophthalmol. 2013 ; 7 : 2137-41.

9) Aoki T, Yokoi N, Kato H, et al. Mechanism and current state of treatment for filamentary keratitis with dry eye [in Japanese]. Nippon Ganka Gakkai Zasshi (J Jpn Ophthalmol Soc). 2019 ; 123 : 1065-70.

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